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Articles 391 - 420 of 256171
Full-Text Articles in Entire DC Network
Comparing Non-Invasive Survey Methods For Southern Flying Squirrels (Glaucomys Volans) At The Western Edge Of Their Range, Jay E. Winfield, Jeremy A. White
Comparing Non-Invasive Survey Methods For Southern Flying Squirrels (Glaucomys Volans) At The Western Edge Of Their Range, Jay E. Winfield, Jeremy A. White
Transactions of the Nebraska Academy of Sciences and Affiliated Societies
The southern flying squirrel (Glaucomys volans) is a threatened species in Nebraska that occurs along the Missouri River in the southeastern corner of the state. Recently, a population was discovered in the city of Lincoln, but it is unknown whether this population represents a natural range expansion from the Missouri River population or whether it is isolated and results from a human-assisted movement. A survey of southern flying squirrels in Nebraska is needed, but surveys of this elusive species are challenging. This study investigated and compared two noninvasive survey techniques for rapid detection of flying squirrels: acoustic detectors …
Assessing Non-Thermal Plasma In Cutaneous Regeneration, Arden Rodriguez, Meliah Martin, Graeme Grainger, Arineh Shahbazi
Assessing Non-Thermal Plasma In Cutaneous Regeneration, Arden Rodriguez, Meliah Martin, Graeme Grainger, Arineh Shahbazi
Discovery Day - Daytona Beach
Chronic and acute wounds remain a significant clinical challenge, particularly in austere and resource-limited environments where access to advanced care is restricted. Non-Thermal Plasma (NTP) has emerged as a promising, non-invasive modality with reported antimicrobial and regenerative properties; however, its mechanisms of action and effects on human skin tissue require further characterization. The scope of this project is to engineer and utilize a 3D human skin epithelial model to evaluate the effects of NTP on wound healing. We will first build a 3D epithelial tissue model that will simulate human skin, followed by modeling and evaluation of wound pathology and …
From Dust To Growth: Microbial Pathways To Extraterrestrial Farming, Stefani Capasso Villanueva, Nupur Kulkarni
From Dust To Growth: Microbial Pathways To Extraterrestrial Farming, Stefani Capasso Villanueva, Nupur Kulkarni
Discovery Day - Daytona Beach
From Dust to Growth: Microbial Pathways to Extraterrestrial Farming addresses the fundamental challenge of sustaining long-term human habitation on other planets. In the era of the Artemis missions, establishing a cost-effective, bioregenerative food source is critical to reducing logistical dependency on Earth, and mitigating the physiological stressors faced by spacecrew through improved nutrition. This study initially investigated the viability of cultivating Mizuna, a proven ISS model organism, in a substrate of Martian regolith simulant amended with organic compost. Following iterative trials, it was found that the plant survival rate was extremely low, even after varying percentages of compost and simulant. …
The Osteocyte-Osteoblast Network Requires Dynamic Mechanical Loading For Key Functions, Kevin Kowalski
The Osteocyte-Osteoblast Network Requires Dynamic Mechanical Loading For Key Functions, Kevin Kowalski
Discovery Day - Daytona Beach
Spaceflight investigations have demonstrated that reduction in gravity-induced loading regimes is detrimental to maintenance Earth-normal bone and marrow. Mechanistically, however, there are still gaps in knowledge about how the reduction in gravity influences the different niches within the tissue. For example, cortical bone is a stable semi-solid structure that allows for only minor deformations before failure, while marrow is a viscous hydrogel-like material that can resist significant fluidic and compressive forces. We hypothesize that maintenance of different niches within the bone microenvironment are dependent on different loading regimes, and that the collective impact if gravity-induced loading needs to be considered …
Impact Of Inspiratory Muscle Training On Diaphragm Hypertrophy, Exercise Performance, And Immune Response, Riley Dienna, Sabrina Ehrenfort, Joshua Frankenfield, Olivia Hartmann, Ben Kerns, Gianpiero Lara, Meliah Martin, Emma Norris, Louis Pandolfo, Rachel Phillips, Stella Roane, Dominic Sandell, Sabrina I. Santini-Bousson, Madison Stroud, Cecilia Zoutewelle, Erica Bryant
Impact Of Inspiratory Muscle Training On Diaphragm Hypertrophy, Exercise Performance, And Immune Response, Riley Dienna, Sabrina Ehrenfort, Joshua Frankenfield, Olivia Hartmann, Ben Kerns, Gianpiero Lara, Meliah Martin, Emma Norris, Louis Pandolfo, Rachel Phillips, Stella Roane, Dominic Sandell, Sabrina I. Santini-Bousson, Madison Stroud, Cecilia Zoutewelle, Erica Bryant
Discovery Day - Daytona Beach
The muscles involved in breathing, notably the diaphragm and intercostal muscles, play a role in determining the exercise capability of an individual. These muscles perform the work required for breathing, and as exercise intensity increases these muscles increase their activity to allow the respiratory system to meet the increased metabolic demands of exercise. Fatigue of these muscles reduces exercise tolerance and performance. In addition, the inflammation caused by acute maximal exercise is impacted by the level of training of the individual, and thus, inspiratory muscle training (IMT) may impact the inflammation due to exercise. We will test the hypothesis that …
From Sunscreen To Seafood: Tracing The Ecological And Human Health Risks Of Oxybenzone Contamination In Local Fish, Alyssa Brasko
From Sunscreen To Seafood: Tracing The Ecological And Human Health Risks Of Oxybenzone Contamination In Local Fish, Alyssa Brasko
Discovery Day - Daytona Beach
Oxybenzone (benzophenone-3) is a widely used ultraviolet (UV) filter in sunscreens, offering protection against harmful radiation but raising significant environmental concerns due to its persistence and toxicity in aquatic ecosystems. This ongoing study aims to investigate the bioaccumulation and ecological impact of oxybenzone in fish species along Florida’s Space Coast, contributing to a broader understanding of its environmental fate and potential human exposure through seafood consumption. The research will employ advanced analytical techniques, including Gas Chromatography-Mass Spectrometry (GC-MS) and High-Performance Liquid Chromatography (HPLC), to quantify oxybenzone levels in locally sourced fish. Fish samples will be obtained from the non-profit organization …
Gene Therapy Strategies To Enhance Antifungal Immunity In Microgravity, Riley Dienna
Gene Therapy Strategies To Enhance Antifungal Immunity In Microgravity, Riley Dienna
Discovery Day - Daytona Beach
During spaceflight, the immune system of astronauts becomes impaired due to microgravity, resulting in increased susceptibility to infections caused by pathogens such as Candida albicans. One of the most common clinical treatments for aggressive candidiasis is amphotericin B, a polyene antimycotic that targeted ergosterol in the fungal cell membrane and compromised the stability of the membrane. However, due to the chemical similarities between ergosterol and cholesterol, this treatment also affects the somatic cells of patients it is administered to. A novel treatment is therefore required to combat the aggressive fungal infection while minimizing damage to the host’s cells. This project …
Modeling Population Growth With Logistic And Modified Logistic Equations, Mihil Dimpal Patel
Modeling Population Growth With Logistic And Modified Logistic Equations, Mihil Dimpal Patel
Discovery Day - Daytona Beach
Population growth models are essential tools for understanding how biological populations change over time under environmental constraints. This study examines population dynamics by comparing the classical exponential growth model with the logistic growth model. While exponential growth assumes unlimited resources and results in unbounded population increase, the logistic model incorporates a carrying capacity that limits growth as resources become scarce. To better represent real-world conditions, the logistic model is extended by introducing modifications such as harvesting terms and time-varying carrying capacities, which account for external removal of individuals and changing environmental limits. The equilibria of these models are determined, and …
Exercise Intensity And The Effects On Mood And Wellbeing, Emily Amortegui, Ashley Albert, Riley Ensor, Keyanna Keyanna Jackson
Exercise Intensity And The Effects On Mood And Wellbeing, Emily Amortegui, Ashley Albert, Riley Ensor, Keyanna Keyanna Jackson
Discovery Day - Daytona Beach
With many students dealing with anxiety, sadness, and high levels of stress, mental health issues among college students have grown in intensity. A lot of research has been done on the possible benefits of physical activity for mental health, but most of it focuses on correlations rather than the biological mechanisms. The purpose of this study is to examine the effects of varying exercise intensities on physiological stress markers and mood in college students ages 18 to 25. To assure precise intensity levels, participants from Embry-Riddle Aeronautical University will work out at low, moderate, and high intensities while wearing heart …
Effects Of Microgravity And Gamma Radiation On Biofilm Growth, Anya Pavlidis, Kaitlyn Mills Mills, Eva Mcclory, Grant Erlinder, Allen Qiu
Effects Of Microgravity And Gamma Radiation On Biofilm Growth, Anya Pavlidis, Kaitlyn Mills Mills, Eva Mcclory, Grant Erlinder, Allen Qiu
Discovery Day - Daytona Beach
Biofilms are collections of bacteria that commonly grow on a variety of surfaces. They are resistant to environmental impacts as bacteria fortify themselves to a surface. Biofilms are commonly found on Earth, but more problematically are also found on spacecraft. On the ISS biofilms have developed in spaces like the workout area, food spaces, and most concerning in the Water Recovery System (WRS). Biofilms tend to react differently to attempted cleaning methods in space than they do on Earth and can be located in extremely difficult to reach places. This study aims to explore the effects of gamma radiation on …
Interactive Effects Of Tissue Temperature And Hydration State On Tendon Mechanical Properties Using A Chicken Drumstick Model, Makayla Maso, Kiara Maso, Mikayla Hulvey
Interactive Effects Of Tissue Temperature And Hydration State On Tendon Mechanical Properties Using A Chicken Drumstick Model, Makayla Maso, Kiara Maso, Mikayla Hulvey
Discovery Day - Daytona Beach
This study focused on the effects of temperature and hydration on tendon extensibility. Four experimental groups were tested using chicken leg tendons tested ex vivo: cold and dehydrated, cold and hydrated, warm and dehydrated, and warm and hydrated. Each treatment group was pulled with an increasing load and measured. It was hypothesized that the warm and hydrated test group would extend the furthest. This was based on studies citing increased bodily flexibility with increasing body temperature as well as stiffness at lower temperatures. Combining temperature and hydration state allowed for not only individual effects of variables to be tested but …
Cross-Reactivity Of 15 Jev Antigen-Directed Rabbit Antisera With Three Clinically Important Jev Serogroup Members: Wnv, Mvev, And Slev, Sang-Im Yun, Young-Min Lee
Cross-Reactivity Of 15 Jev Antigen-Directed Rabbit Antisera With Three Clinically Important Jev Serogroup Members: Wnv, Mvev, And Slev, Sang-Im Yun, Young-Min Lee
Animal, Dairy, and Veterinary Science Faculty Publications
Japanese encephalitis virus (JEV), the prototype member of the JEV serogroup within the genus Orthoflavivirus (family Flaviviridae), is closely related to West Nile virus (WNV), Murray Valley encephalitis virus (MVEV), and St. Louis encephalitis virus (SLEV). To characterize antigenic cross-reactivity within this group, we evaluated 15 region-specific rabbit antisera, previously generated against nearly the entire JEV protein-coding region, by immunoblotting whole-cell lysates from BHK-21 cells infected with WNV, MVEV, or SLEV, with JEV included as a reference. Six antisera (α-EN-term, α-NS2B, α-NS3N-term, α-NS3C-term, α-NS5N-term, and α-NS5C-term) robustly recognized homologous …
First Insular Record And Dna Barcoding Of Euscorpius Vailatii Tropea & Fet, 2015 From Trizonia Island (Fokida, Greece), Konstantinos Kalaentzis, Francesco Frigioni, Alexios Panagiotopoulos, Elias Tzoras, Styliani Minoudi, Alexandros Triantafyllidis
First Insular Record And Dna Barcoding Of Euscorpius Vailatii Tropea & Fet, 2015 From Trizonia Island (Fokida, Greece), Konstantinos Kalaentzis, Francesco Frigioni, Alexios Panagiotopoulos, Elias Tzoras, Styliani Minoudi, Alexandros Triantafyllidis
Euscorpius
Euscorpius vailatii Tropea & Fet, 2015 (Scorpiones: Euscorpiidae), originally described from Aitoloakarnania and Fokida (Greece), is herein reported from Trizonia Island in the Gulf of Corinth, representing the first insular record for the species. The examined specimens are consistent with the diagnostic morphology of E. vailatii. The first molecular data for the species are provided, based on both mainland and insular populations. Comparative analyses further highlight the distinctiveness of E. vailatii from geographically close congeners, while phylogenetic results indicate a sister-taxon relationship with E. erymanthius, supporting a Quaternary biogeographic history shaped by the evolution of the Gulf of …
Escherichia Coli Concentrations In Sand And Water At Tributary-Influenced Lake Michigan Beaches, Josie Elaine Kuhlman
Escherichia Coli Concentrations In Sand And Water At Tributary-Influenced Lake Michigan Beaches, Josie Elaine Kuhlman
Masters Theses
Contamination of public recreational water and sand is a human health concern, creating a management challenge for public health officials. Past research has shown that Escherichia coli can persist in sediment and can be washed into recreational water. Currently, beach monitoring practices only utilize E. coli concentrations in water samples to determine beach safety and do not consider potential exposure to sediment/sand concentrations. In this study, I investigated the relationship between E. coli concentrations in water and sand samples, which will aid public health officials in making more informed decisions about beach closures. I utilized culture-based measurements of E. coli …
Transcriptomic Profiling Of The Donkey Endometrium Reveals Dynamic Molecular Transitions Across The Estrous Cycle, Limeng Shi, Shuaishuai Wu, Mingyue Zhao, Wenhao Zhou, Abd Ullah, Muhammmad F. Akhtar, Changfa Wang, Muhammad Z. Khan, Ying Han
Transcriptomic Profiling Of The Donkey Endometrium Reveals Dynamic Molecular Transitions Across The Estrous Cycle, Limeng Shi, Shuaishuai Wu, Mingyue Zhao, Wenhao Zhou, Abd Ullah, Muhammmad F. Akhtar, Changfa Wang, Muhammad Z. Khan, Ying Han
The Thai Journal of Veterinary Medicine
The endometrium undergoes extensive cyclical remodeling essential for reproductive success; however, the molecular mechanisms governing these processes in donkeys (Equus asinus) remain poorly characterized. To address this gap, we performed high-throughput RNA sequencing on endometrial tissues collected from Dezhou donkeys (n = 16) at four post-ovulation stages: Day 0 (ovulation), Day 3 (early luteal), Day 7 (mid-luteal), and Day 18 (late luteal/pre-luteolysis). Differential gene expression analysis, Gene Ontology enrichment, and KEGG pathway mapping were conducted to characterize temporal transcriptomic dynamics. We identified 2,474, 6,548, and 1,288 differentially expressed genes in Day 0 versus Day 3, Day 0 versus …
Adaptive Phishing Url Detection Using Hybrid Fuzzy C-Means Clustering And Xgboost, Muntadher Mohammed Kareem, Rawaa I. Farhan
Adaptive Phishing Url Detection Using Hybrid Fuzzy C-Means Clustering And Xgboost, Muntadher Mohammed Kareem, Rawaa I. Farhan
Karbala International Journal of Modern Science
Phishing attacks continue to evolve in sophistication, rendering static detection methods increasingly ineffective. Existing URL-based approaches suffer from limited adaptability to emerging phishing patterns, mislabeled training data, and insufficient validation protocols. This paper proposes a hybrid phishing URL detection system that integrates Fuzzy C-Means (FCM) clustering with XGBoost classification, enhanced by a novel Micro Adaptive Feature Extractor (MAFE). The system employs a multi-stage pipeline: feature engineering generating 36 statistical and interaction features, MAFE producing 15 adaptive features through class-aware dynamic weighting, micro-pattern detection, and entropy analysis, and FCM with K=2 clusters providing soft membership features to XGBoost. A two-pass confidence-based …
Ai-Enhanced Fluorescein Angiography Detection Of Diabetes-Induced Silent Retinal Capillary Dropout And Rna-Seq Identification Of Pre-Symptomatic Biomarkers, Yiyan Peng, Huishi Toh, Dennis Clegg, Peng Jiiang
Ai-Enhanced Fluorescein Angiography Detection Of Diabetes-Induced Silent Retinal Capillary Dropout And Rna-Seq Identification Of Pre-Symptomatic Biomarkers, Yiyan Peng, Huishi Toh, Dennis Clegg, Peng Jiiang
Biological, Geological, and Environmental Faculty Publications
Objective: Retinal capillary dropout, characterized by acellular capillaries or "ghost vessels," is an early pathological sign of diabetic retinopathy (DR) that remains undetectable through standard clinical imaging techniques until visible morphological changes, such as microaneurysms or hemorrhages, occur. This study aims to develop a non-destructive artificial intelligence (AI)-based method using fluorescein angiography (FA) images to detect early-stage, silent retinal capillary dropout.
Methods: We utilized 94 FA images and corresponding destructive retinal capillary density measurements obtained through retinal trypsin digestion from 51 Nile rats. Early capillary dropout was defined as having an acellular capillary density of >= 18 counts per mm2. …
Phenological Plasticity Provides Limited Resilience To Climate Warming In A Sea Turtle Species With Temperature-Dependent Sex Determination, Blair P. Bentley, Lisa M. Komoroske, Cintia M. Santos, Armando J. B. Santos, Estefany Argueta, Vic Quennessen, Christina M. Coppenrath, Camille Kynoch, Vincent S. Saba, Claudio Bellini, Rafaely N. M. S. Ventura, J. Wilson White, Mariana M. P. B. Fuentes
Phenological Plasticity Provides Limited Resilience To Climate Warming In A Sea Turtle Species With Temperature-Dependent Sex Determination, Blair P. Bentley, Lisa M. Komoroske, Cintia M. Santos, Armando J. B. Santos, Estefany Argueta, Vic Quennessen, Christina M. Coppenrath, Camille Kynoch, Vincent S. Saba, Claudio Bellini, Rafaely N. M. S. Ventura, J. Wilson White, Mariana M. P. B. Fuentes
Biological Sciences: Faculty Publications
Anthropogenic climate change is threatening global biodiversity, with sea turtles particularly vulnerable as offspring sex and developmental success are strongly influenced by incubation temperature. Behavioral plasticity, including the seasonal distribution of reproductive output, may provide short-term mechanisms for mitigating these impacts. Here, we investigated season-wide hatchling sex ratios and emergence success in a small population of green turtles (Chelonia mydas), tracking individual females across their nesting seasons. Sex ratios varied markedly through the nesting season, with later nests producing a greater proportion of male hatchlings. Moreover, sex ratios were relatively consistent among nests laid by individual females. Overall, females producing …
Enzymatic Synthesis Of Salicylate In Yersina Pestis Proceeds Via Intramolecular Hydroxyl Group Transfer., Clarke Miller
Enzymatic Synthesis Of Salicylate In Yersina Pestis Proceeds Via Intramolecular Hydroxyl Group Transfer., Clarke Miller
Georgia Journal of Science
The salicylate synthase (YbtS) of Yersinia pestis catalyzes the initial step in the biosynthesis of yersiniabactin, an iron-scavenging siderophore and critical virulence factor. While YbtS is proposed to share a reaction mechanism with other anthranilate synthase homologs, the exact catalytic pathway has remained unresolved. In this work, stable isotope (18O) labeling and mass spectrometry are utilized to clarify the catalytic mechanism of YbtS. The results of the following set of experiments demonstrate that the salicylate hydroxyl group does not originate from solvent water, directly challenging previously proposed models. Instead, the lack of solvent-labeled oxygen incorporation and the absence …
Snails In The Diet Of The Cutlip Minnow, Exoglossum Maxillingua, Tess A. Taloumis, Steven L. Powers
Snails In The Diet Of The Cutlip Minnow, Exoglossum Maxillingua, Tess A. Taloumis, Steven L. Powers
Southeastern Fishes Council Proceedings
The Cutlip Minnow, Exoglossum maxillingua, is an important stream fish native to the eastern United States. It has an unusual lower jaw morphology. Early hypotheses suggested the jaw morphology is an adaptation for feeding on snails. Despite the publication of numerous diet studies on this species, there is no documentation of snails as prey items. During recent snorkel observations in the Roanoke River, E. maxillingua was spotted carrying snails within their mouths, prompting further investigation. An in-depth temporal examination of the diet from 145 specimens of E. maxillingua across multiple sites was conducted to further investigate the diet of …
Comparative Analysis Of Artificial Intelligence (Ai) Implications For Active Learning And Assessment At Various Curricular Levels Of Stem And Health Sciences In Developed Versus Underprivileged Countries, Vinay Munlapudi, Santanu De
Comparative Analysis Of Artificial Intelligence (Ai) Implications For Active Learning And Assessment At Various Curricular Levels Of Stem And Health Sciences In Developed Versus Underprivileged Countries, Vinay Munlapudi, Santanu De
FDLA Journal
Today’s all-pervasive emergence of artificial intelligence (AI) necessitates a comprehensive evaluation of its role in education, especially for occupational disciplines in health sciences and STEM. AI has reshaped student learning and instructors’ navigation of the evolving, post coronavirus infectious disease (COVID-19) global academic landscape. This study aimed at encapsulating evidence-based AI implications for student-centered, active learning and assessment at various curricular levels of science, technology, engineering, mathematics (STEM) and health sciences education in developed versus underprivileged or less developed countries. An extensive, scoping review of 65 recent, scholarly publications was conducted over six months through diverse search engines (PubMed, Google …
In Vitro Digestion Modifies Lepidium Meyenii Extract, Altering Its Major Glucosinolates, Lepidilines, Β-Carbolines, And Gut Bacterial Growth, Dominik Tarabasz, Ewa Baranowska-Wójcik, Paweł Szczeblewski, Tomasz Laskowski, Klaudia Gustaw, Marzena Furtak-Niczyporuk, Dominik Szwajgier, Rita Cristina Orihuela-Campos, Henry O. Meissner, Julia Borzyszkowska-Bukowska, Wirginia Kukula-Koch
In Vitro Digestion Modifies Lepidium Meyenii Extract, Altering Its Major Glucosinolates, Lepidilines, Β-Carbolines, And Gut Bacterial Growth, Dominik Tarabasz, Ewa Baranowska-Wójcik, Paweł Szczeblewski, Tomasz Laskowski, Klaudia Gustaw, Marzena Furtak-Niczyporuk, Dominik Szwajgier, Rita Cristina Orihuela-Campos, Henry O. Meissner, Julia Borzyszkowska-Bukowska, Wirginia Kukula-Koch
Journal of Food and Drug Analysis
The tubers of Lepidium meyenii (commonly known as maca) have been used in the Andean cuisine for ages. The study aims to determine the behavior of the extract from the red phenotype of maca in the in vitro gastrointestinal tract model and also to define the overall impact of the extract on the microbiota. Glucosinolates, lepidilines, and a derivative of β-carboline alkaloid, i.e. 1-methyltetrahydro-β-5,6-hydride-carboline-3-carboxylic acid, as representatives of one of the main groups of metabolites were selected for the quantitative analysis after in vitro digestion at every stage of the digestion model. The results showed that lepidilines …
A Comprehensive In-Silico Pipeline For The Discovery Of Non-Toxic, Stable Antimicrobial Peptides From Databases For Targeting Multi-Drug Resistant K. Pneumoniae, Pranab D. Sharma, Abdullah A. Noman, Al Hafiz
A Comprehensive In-Silico Pipeline For The Discovery Of Non-Toxic, Stable Antimicrobial Peptides From Databases For Targeting Multi-Drug Resistant K. Pneumoniae, Pranab D. Sharma, Abdullah A. Noman, Al Hafiz
Faculty Articles
The rapid emergence of multidrug-resistant Klebsiella pneumoniae has significantly reduced the effectiveness of conventional antibiotics, highlighting the need for alternative therapeutic strategies. This study employed a comprehensive in silico pipeline to identify antimicrobial peptides (AMPs) targeting the essential DNA replication initiator protein DnaA. A total of 28,361 peptide sequences were collected from publicly available AMP databases and sequentially filtered based on peptide length, net charge, GRAVY score, instability index, antimicrobial activity, toxicity, hemolytic potential, aggregation propensity, sequence similarity and favorable amphipathic properties. Four peptides satisfied all selection criteria and were subjected to structural prediction, membrane-binding analysis, protein–DNA docking, protein–peptide docking, …
Dose-Expansion Study Of Obi-999, A Globo H-Targeting Antibody-Drug Conjugate, In Patients With Advanced Solid Tumors, Apostolia Maria Tsimberidou, Darren Sigal, Anna Varghese, Daniel Vaena, Li-Yuan Bai, Ming-Huang Chen, Chun-Nan Yeh, Chia-Jui Yen, Mehmet A Baysal, Abhijit Chakraborty, Ingly Lee, Chi-Sheng Shia, Konul Ristoski, Dong Xu
Dose-Expansion Study Of Obi-999, A Globo H-Targeting Antibody-Drug Conjugate, In Patients With Advanced Solid Tumors, Apostolia Maria Tsimberidou, Darren Sigal, Anna Varghese, Daniel Vaena, Li-Yuan Bai, Ming-Huang Chen, Chun-Nan Yeh, Chia-Jui Yen, Mehmet A Baysal, Abhijit Chakraborty, Ingly Lee, Chi-Sheng Shia, Konul Ristoski, Dong Xu
Children’s Nutrition Research Center Staff Publications
Background: OBI-999 is an antibody-drug conjugate consisting of the Globo H-targeting antibody OBI-888 linked to the cytotoxic payload monomethyl auristatin E. In a dose-escalation study, the OBI-999 recommended phase 2 dose (RP2D) was 1.2 mg/kg every 3 weeks. This dose-expansion study evaluated the efficacy and safety of OBI-999 in patients with pancreatic cancer, colorectal cancer (CRC), or other tumor types ("basket cohort") and tumoral Globo H H-scores ≥100 (NCT04084366).
Patients and methods: Patients were treated at RP2D of OBI-999. We assessed response, progression-free survival (PFS), treatment-emergent adverse events (TEAEs), and pharmacokinetics of OBI-999.
Results: Of 29 patients treated, …
Descriptive Anatomy Of The Female Reproductive Organs In Thamin Eld’S Deer (Rucervus Eldii Thamin) And Fea’S Muntjac (Muntiacus Feae) With Utilizing Of The Glycerin Impregnation Technique For Specimen Preservation, Paisan Tienthai, Pawana Chuesiri, Itti Boonorrana, Piyaporn Kongmakee, Ampika Thongphakdee
Descriptive Anatomy Of The Female Reproductive Organs In Thamin Eld’S Deer (Rucervus Eldii Thamin) And Fea’S Muntjac (Muntiacus Feae) With Utilizing Of The Glycerin Impregnation Technique For Specimen Preservation, Paisan Tienthai, Pawana Chuesiri, Itti Boonorrana, Piyaporn Kongmakee, Ampika Thongphakdee
The Thai Journal of Veterinary Medicine
The reproductive anatomy of rare cervid species remains insufficiently documented, limiting comparative studies and preservation efforts. This study describes the anatomical details in the female reproductive organs of Thamin Eld’s deer (Rucervus eldii thamin) and Fea’s muntjac (Muntiacus feae), while the application of a modified glycerin impregnation technique was achieved for specimen preservation. Dissections of female reproductive tracts revealed morphological variations that correlate with the known female reproductive characteristics of domestic and closely related species. In both species, the ovaries were characterized as small, ovoid structures, exhibiting prominent follicles or corpora lutea consistent with the stage …
Enhancing Nutrition Communication Skills Through Community-Based Learning To Create Cooperative Extension Resources, Elizabeth Lucas Combs, Anna Cason, Courtney Luecking, Heather Norman-Burgdolf
Enhancing Nutrition Communication Skills Through Community-Based Learning To Create Cooperative Extension Resources, Elizabeth Lucas Combs, Anna Cason, Courtney Luecking, Heather Norman-Burgdolf
Journal of Dietetic Education
Strong communication and transferable skills are essential for future dietitians. This Best Evidence Teaching Strategy describes a community-based approach within an upper-level community nutrition course that partnered with the Cooperative Extension Service. Over six weeks, scaffolded assignments emphasized written, oral, and digital media skills, aligning with current trends in scientific communication. Students created information releases, podcasts, and short videos to translate evidence-based nutrition content into accessible formats for public audiences. Collaboration with Extension provided authentic context and motivation, as high-quality projects could be disseminated statewide.
The Registered Dietitian Nutritionist’S Implementation Of Dysphagia Screening In Clinical Practice: A Commentary, Nicole Wiksten, Holly Estes-Doetsch, Laura C. Boucher, Sarah Rusnak, Kristen M. Roberts
The Registered Dietitian Nutritionist’S Implementation Of Dysphagia Screening In Clinical Practice: A Commentary, Nicole Wiksten, Holly Estes-Doetsch, Laura C. Boucher, Sarah Rusnak, Kristen M. Roberts
Journal of Dietetic Education
Background: The Accreditation Council for Education in Nutrition and Dietetics (ACEND) amended the competencies for the future education model (FEM) in dietetic education to include competency 3.6 stating that the Registered Dietitian Nutritionist (RDN) must be able to "Initiate and conduct bedside swallow screenings". There is no clear process for RDNs to implement dysphagia screening in practice or academia. The aim of this review is to inform clinicians and educators on current literature discussing current RDN and speech language pathology approaches to dysphagia screening and to provide a proposed curriculum for implementation of competency 3.6 in clinical practice and academia.
Measuring The Empathy Of Nutrition And Dietetics Students With The Jefferson Scale Of Empathy – Health Professions Student Version: A Pilot Study, Sara Tamsukhin, Youn Seon Lim
Measuring The Empathy Of Nutrition And Dietetics Students With The Jefferson Scale Of Empathy – Health Professions Student Version: A Pilot Study, Sara Tamsukhin, Youn Seon Lim
Journal of Dietetic Education
The purpose of this study was to learn about undergraduate nutrition and dietetics students’ empathy scores. The study was a descriptive quantitative design with a web-based, cross-sectional survey. Participants were undergraduate nutrition and dietetics students from two universities who completed a survey with demographic questions, clinical experience questions, and the Jefferson Scale of Empathy – Health Professions Student version (JSE-HPS©). Seventy-one nutrition and dietetics students completed the survey. Most respondents were female, white, and non-Hispanic. The mean total empathy score was 114.69 (SD=11.09) with a range of 81 to 137. Welch’s t-test did not show significant differences by gender, ethnicity, …
Disability-Related Educational Content In Nutrition And Dietetic Programs: An Exploratory Study, Wendy Medunick, Allison Gomes, Joachim Sackey, Laura Byham-Gray, Jane Ziegler
Disability-Related Educational Content In Nutrition And Dietetic Programs: An Exploratory Study, Wendy Medunick, Allison Gomes, Joachim Sackey, Laura Byham-Gray, Jane Ziegler
Journal of Dietetic Education
Background: Health disparities experienced by people with disabilities (PWD) are partly attributed to inadequate knowledge, training, confidence and competence regarding disabilities among health professionals. While registered dietitian nutritionists (RDNs) are key members of the healthcare team, it is unclear how pre-professional nutrition and dietetics (ND) programs prepare future RDNs to care for PWD. This study examined the status of disability-related education within ND programs in the United States. Methods: A descriptive cross-sectional electronic survey was distributed to 570 directors of accredited ND programs. The survey, which adapted questions from a previously validated instrument and published studies, included questions assessing disability-related …
Assessing And Addressing Cultural Competence And Cultural Humility In Dietetic Education, Zoe Duran, Nicholas Slagel, Lisa Caldwell, Katie Kage
Assessing And Addressing Cultural Competence And Cultural Humility In Dietetic Education, Zoe Duran, Nicholas Slagel, Lisa Caldwell, Katie Kage
Journal of Dietetic Education
Limited theory-informed, dietetic-specific resources are available to guide the development, evaluation, and refinement of culturally competent (CC) curricula. This pilot study used a mixed-methods, theory-informed approach to evaluate CC integration within an undergraduate dietetics curriculum and examine the applicability of existing CC self-assessment tools for dietetic students. A senior-level undergraduate community nutrition curriculum was evaluated using the Tool for Assessing Cultural Competence Training (TACCT), guided by the Campinha-Bacote Model of Cultural Competence in Healthcare Delivery. James Banks’ Model of Multicultural Curriculum Reform was then applied to refine curricular content and learning activities. In addition, 74 students enrolled in a didactic …