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Beyond The Brain: Environmental Forces Driving Α-Synuclein Misfolding And Toxic Aggregation In Parkinson's Disease, Emily Mccarthy Apr 2026

Beyond The Brain: Environmental Forces Driving Α-Synuclein Misfolding And Toxic Aggregation In Parkinson's Disease, Emily Mccarthy

Celebrating Scholarship and Creativity Day (2018-)

Parkinson's disease (PD) is an advanced neurodegenerative disorder characterized by the degeneration of dopaminergic neurons and the proliferation of protein aggregates within the brain. This capstone thesis investigates the unique biochemical environment of the gastrointestinal tract and whether it contributes to the formation of distinctive α-Synuclein (αSyn) aggregates affecting PD. Key promoters of αSyn aggregation include genetic mutations, oxidative stress, post-translational modifications, interactions with metal ions, and dopamine (DA) oxidation. These factors result in diverse structures such as oligomers, protofibrils, and fibrils, which result in unique functional outcomes, with oligomeric conformations leading to the highest level of neuronal toxicity. Evidence …

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Target-Site Resistance To Glyphosate In Eleusine Indica Biotypes From South Sulawesi And Lampung, Indonesia, Ahmad Nur Lazuardi, Denny Kurniadie, Uum Umiyati, Ryan Widianto Apr 2026

Target-Site Resistance To Glyphosate In Eleusine Indica Biotypes From South Sulawesi And Lampung, Indonesia, Ahmad Nur Lazuardi, Denny Kurniadie, Uum Umiyati, Ryan Widianto

Jurnal Kultivasi

Glyphosate is a non-selective systemic herbicide that has been widely used to control weeds by local corn farmers in South Sulawesi and Lampung Provinces of Indonesia. However, some corn farmers in these two regions were considered that glyphosate herbicide at the standard field dose no longer effective against goosegrass (Eleusine indica). To confirms the level of its resistance to glyphosate, seeds of E. indica suspected to be glyphosate-resistant were collected from corn fields in Soppeng Regency-South Sulawesi and South Lampung Regency-Lampung (designated as GR-1 and GR-2 respectively), along with a known susceptible biotype from Sumedang Regency-West Java (GS) as a …

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Growth Of Vanilla Cuttings Under Modified Acid Soil Media And Application Of Several Plant Growth Regulators, Rifqi Raditya Kurniawan, Yugi Rahayu Ahadiyat, Etik Wukir Tini Apr 2026

Growth Of Vanilla Cuttings Under Modified Acid Soil Media And Application Of Several Plant Growth Regulators, Rifqi Raditya Kurniawan, Yugi Rahayu Ahadiyat, Etik Wukir Tini

Jurnal Kultivasi

This research aimed to optimize the growth of vanilla (Vanilla planifolia) cuttings in acid soils by modifying the growing media and applying several types of plant growth regulators (PGRs). Several types of PGRs, including synthetic compounds such as indole-3-acetic acid (IAA) and 6-benzylaminopurine (BAP), as well as natural extracts from shallot (Allium ascalonicum L.) and moringa leaves (Moringa oleifera), were tested to enhance plant performance in acid-growing conditions. The primary objectives were to determine the optimal soil amendment formula and the most effective PGR type for promoting vanilla growth, and to develop a measurable, easy-to-use PGR formulation accessible to farmers. …

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Response Of Chlorophyll, Morphology, And Yield Of Several East Java Superior Soybean (Glycine Max L.) Varieties To Levels Of Salinity, Puji Lestari Tarigan, Ida Retno Moeljani, Fadila Suryandika, Hadi Munarko Apr 2026

Response Of Chlorophyll, Morphology, And Yield Of Several East Java Superior Soybean (Glycine Max L.) Varieties To Levels Of Salinity, Puji Lestari Tarigan, Ida Retno Moeljani, Fadila Suryandika, Hadi Munarko

Jurnal Kultivasi

Soybean production has been extended to saline areas. This development is a strategy to expand planting areas to suboptimal land to increase worldwide production. To support cultivation in these locations, it is necessary to develop superior varieties that are resistant to salinity and provide supporting technological inputs. In saline conditions, soybeans may face stress that leads to morphological, physiological, and yield disturbances. Consequently, the response of several soybeans in East Java should be observed. This study is a pot experiment and arranged in a Factorial Completely Randomized Design (CRD) consisting of two factors, soybean varieties and NaCl concentrations. The treatments …

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The Effect Of Liquid Foliar Fertilizer And Pruning Combinations On The Growth Of Productive Phase Arabica Coffee Plants (Coffea Arabica L.), Syifa Djuita Putri, Alvito Krishna Balapradhana, Mira Ariyanti, Intan Ratna Dewi Anjarsari, Yudithia Maxiselly Apr 2026

The Effect Of Liquid Foliar Fertilizer And Pruning Combinations On The Growth Of Productive Phase Arabica Coffee Plants (Coffea Arabica L.), Syifa Djuita Putri, Alvito Krishna Balapradhana, Mira Ariyanti, Intan Ratna Dewi Anjarsari, Yudithia Maxiselly

Jurnal Kultivasi

In recent years, productivity decline in arabica coffee has become a real issue in Indonesia. This decay has been brought about by various external and internal factors that are beyond human control. Various factors, including suboptimal cultivation practices, take part in this process. The objective of the present study was to evaluate the effect of pruning combined with foliar fertilizer application (coconut water and sugarcane molasses) and 6-benzylaminopurine (BAP) on the vegetative growth of arabica coffee plants during the production phase. The research was conducted at Ciparanje Experimental Field, Universitas Padjadjaran, using a randomized complete block design with seven treatments …

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Morphology And Bioactive Compounds Of Gurmar (Gymnema Sylvestre) With Potential As Antidiabetics, Neny Novita Yuliany, Abdillah Maulana Farhan, Putry Lazimatu Ziyaroh, Edia Fitri Dwinianti, Husnatun Nihayah, Mukhamad Su'udi Apr 2026

Morphology And Bioactive Compounds Of Gurmar (Gymnema Sylvestre) With Potential As Antidiabetics, Neny Novita Yuliany, Abdillah Maulana Farhan, Putry Lazimatu Ziyaroh, Edia Fitri Dwinianti, Husnatun Nihayah, Mukhamad Su'udi

Jurnal Kultivasi

The medicinal plant Gymnema sylvestre is widely known for its ability to lower blood sugar levels. This study reviewed the physical characteristics and bioactive compounds of G. sylvestre sourced from different regions, emphasizing its potential as an antidiabetic agent. Morphological analysis includes leaf structure, trichome presence, and other anatomical features, which can influence the plant's chemical profile. Phytochemical analysis, performed using techniques like GC-MS, identifies key bioactive compounds such as saponins, flavonoids, and gymnemic acids, which contribute to its hypoglycemic effect. The findings indicate that regional variations can affect the concentration and presence of these compounds, suggesting that environmental factors …

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Optimization Of Physalis Angulata L. Callus Induction And Salinity-Induced Antioxidant Production, Firstian Naufal Sistyananda, Erni Suminar, Anne Nuraini, Muhamad Kadapi, Murgayanti, Syariful Mubarok, Rahmat Budiarto, Eddy Renaldi, Kusumiyati Apr 2026

Optimization Of Physalis Angulata L. Callus Induction And Salinity-Induced Antioxidant Production, Firstian Naufal Sistyananda, Erni Suminar, Anne Nuraini, Muhamad Kadapi, Murgayanti, Syariful Mubarok, Rahmat Budiarto, Eddy Renaldi, Kusumiyati

Jurnal Kultivasi

Groundcherry (Physalis angulata L.) is a plant with many medicinal potentials due to its rich secondary metabolites such as phenolic and flavonoid. However, conventional agriculture practices are still limited, especially in Indonesia. This study was divided into two stages. The first stage was conducted to determine optimal 6-BAP and 2,4-D combination for callus induction, while the second stage was conducted to determine callus phenolic, flavonoid, and antioxidant response to salinity stress. The first stage was arranged in factorial completely randomized design with two factors: 6-BAP (0, 2, and 4 mg/L) and 2,4-D (0, 0.5, 1, and 1.5 mg/L). The second …

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Growth And Yield Response Of Shallots To Npk, Nk, And Humic Acid Under Different Mycorrhiza Application, Alfu Laila, Endang Sulistyorini Apr 2026

Growth And Yield Response Of Shallots To Npk, Nk, And Humic Acid Under Different Mycorrhiza Application, Alfu Laila, Endang Sulistyorini

Jurnal Kultivasi

One strategy to increase shallot production is the utilization of microorganisms in the soil, such as arbuscular mycorrhizal fungi (AMF), which is applied together with fertilizer. This research aimed to investigate the effects of different nutrient inputs and mycorrhizal association on the growth and yield of shallots. This study used a split-plot design with three replications as blocks. The main plot included four treatments: no nutrient inputs, NPK fertilizer, NK fertilizer, and humic acid, while the subplot involved the mycorrhiza application (with or without). The measured variables included growth (plant height and number of leaves) and yield (fresh weight and …

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Discovering The Genetics Underlying Speciation Traits In Heuchera (Coral Bells), Tajinder Singh Apr 2026

Discovering The Genetics Underlying Speciation Traits In Heuchera (Coral Bells), Tajinder Singh

Honors Theses

Hybridization is a key evolutionary mechanism for generating biological diversity, ultimately shaping diversification and adaptation of plant lineages in natural and agroecosystems.  Our understanding of the frequency, distribution, and significance of hybridization is rapidly increasing, but the external driving forces that dictate why certain species hybridize, and others do not remain obscure. The physical traits that shape gene flow and trait sharing among species are likely to be among the key factors that directly control hybridization. Gene flow in most plants is mediated by pollinating insects and thus by pollination syndromes, which are suites of floral traits that have evolved …

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Investigating The Synthesis And Antibacterial Activity Of A Main-Chain Cationic Polymer, Emily Smith Apr 2026

Investigating The Synthesis And Antibacterial Activity Of A Main-Chain Cationic Polymer, Emily Smith

Honors Theses

Antibiotic resistance is a growing threat to public health. Due to the overuse of antibiotics in agriculture, the overprescription of antibiotics, and the misuse of antibiotics by patients, antibiotic resistance is spreading at an alarming rate. As antibiotic resistance spreads, the antibiotics we depend on to treat common infections become ineffective. Therefore, it is imperative to develop novel treatments for infections that do not increase the prevalence of antibiotic resistance. One treatment being explored is the use of synthetic polymers with antibacterial properties. Synthetic polymers are advantageous because they can be synthesized from widely available precursors and their structure is …

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Cleft Palate And The Coordination Of Wnt Signaling And Pax9 In Murine Palatogenesis, Landon Wyatt Apr 2026

Cleft Palate And The Coordination Of Wnt Signaling And Pax9 In Murine Palatogenesis, Landon Wyatt

Honors Theses

Cleft palate is a common craniofacial birth defect that arises when the molecular and morphogenetic events guiding secondary palate formation lose coordination during a narrow developmental window. In mice, successful palatogenesis requires the paired palatal shelves to grow vertically, elevate above the tongue, and fuse at the midline; disruption of any of these steps can result in clefting. Two important regulators of this process are canonical Wnt signaling and the transcription factor Pax9, both of which contribute to normal palatal mesenchymal growth and patterning during early development. This paper first examines whether altered Dkk1/Wnt signaling contributes to the Pax9-null palate …

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Sex Or Survival: Does Wounding Elicit A Somatic Reproductive Tradeoff In Narnia Femorata Males?, Lillian E. Burbulis Apr 2026

Sex Or Survival: Does Wounding Elicit A Somatic Reproductive Tradeoff In Narnia Femorata Males?, Lillian E. Burbulis

Departmental Honors & Graduate Capstone Projects

Animals must partition resources into different life history traits resulting in tradeoffs because resources are finite. A tradeoff is the allocation of resources to one trait over another. Theory states that energy is allocated in a hierarchical fashion. For example, somatic maintenance should be a higher priority than reproduction, resulting in more resources being allocated to somatic maintenance compared to reproductive traits. The metabolic investment hypothesis states that energy must follow a hierarchical order prioritizing somatic maintenance over reproduction. Another hypothesis for energy allocation is the terminal investment hypothesis. This hypothesis states that energy will be allocated to reproduction over …

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Ai-Driven Multispectral Drone Monitoring For Afforestation In Arid Environments, Hesham Morgan, Ali Elgendy, Brandon Tran, Tamer Ismail, Mohamed M. Moursy, Yehya Kh. Shehadeh, Ahmed Elgharib, Ahmed Abdullah Al-Dughairi, Ali El Mubarak, Khaled Allam Harhash, Hesham El-Askary Apr 2026

Ai-Driven Multispectral Drone Monitoring For Afforestation In Arid Environments, Hesham Morgan, Ali Elgendy, Brandon Tran, Tamer Ismail, Mohamed M. Moursy, Yehya Kh. Shehadeh, Ahmed Elgharib, Ahmed Abdullah Al-Dughairi, Ali El Mubarak, Khaled Allam Harhash, Hesham El-Askary

Mathematics, Physics, and Computer Science Faculty Articles and Research

Monitoring large-scale afforestation projects in arid and semi-arid environments requires accurate, high-resolution, and repeatable methods to assess tree survival and growth. In this study, we integrated unmanned aerial vehicle (UAV) multispectral imaging with an advanced object detection framework to evaluate vegetation establishment in the Shuayb Al-Budai afforestation site, part of the Imam Turki bin Abdullah Royal Natural Reserve, Kingdom of Saudi Arabia (KSA). Multispectral datasets were acquired using a MicaSense Altum-PT sensor and processed through a masked Region-based Convolutional Neural Network (RCNN) with two backbone architectures: ResNet-101 and VGG19-BN. The Mask R-CNN–ResNet-101 model achieved superior performance, with an overall accuracy …

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A Two-Phase Hippocampal Code Linking Time And Distance Estimation To Action, Raphael Heldman Apr 2026

A Two-Phase Hippocampal Code Linking Time And Distance Estimation To Action, Raphael Heldman

Electronic Theses and Dissertations

A critical component of spatial navigation is the ability to estimate elapsed time or distance traveled. How the brain generates such estimates and links them to behavior remains unclear. In this thesis, we identify a previously unrecognized population coding strategy for time or distance in hippocampal CA1, a region critical for navigation and memory. Using novel behavioral paradigms in head-fixed mice combined with electrophysiological recordings, we show that this code is carried by two functionally distinct subpopulations of pyramidal neurons, termed PyrUp and PyrDown, whose firing rates evolve in opposite directions during navigation. Both populations exhibit a common two-phase dynamic: …

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Elucidating The Role Of The Gastrointestinal Microbiome And Diet In Dopamine Release In Relation To Attention-Deficit/Hyperactivity Disorder., Meaghan Mcdonald Apr 2026

Elucidating The Role Of The Gastrointestinal Microbiome And Diet In Dopamine Release In Relation To Attention-Deficit/Hyperactivity Disorder., Meaghan Mcdonald

Celebrating Scholarship and Creativity Day (2018-)

Currently affecting 340-580 million people worldwide, ADHD is a neurodevelopmental disorder that affects how the brain controls attention, behaviour and impulses often beginning in childhood and continuing into adulthood. ADHD is known to be associated with monoamine neurotransmitters including dopamine. This work aims to uncover the ways in which metabolism of monoamine precursors in the gastrointestinal microbiome influences dopamine release in the brain. Previous studies have indicated that children with ADHD display distinct gut bacteria profiles with unique microbiota species that result in the disruption of monoamine precursor pathways of phenylalanine and tyrosine metabolism. Emphasis on our western diet and …

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The Big Picture Of The Small Intestine, Reagan Kangas Apr 2026

The Big Picture Of The Small Intestine, Reagan Kangas

Celebrating Scholarship and Creativity Day (2018-)

Histology is the study of microscopic tissue structures and is used to understand the function of tissues and visualize the cellular organization within them. It is an important tool in biology and medicine, used for diagnosing disease (i.e., cancers, infections, inflammatory diseases, etc.) and studying organ structure and function. The goal of this poster is to compare preparation and staining techniques, specifically paraffin versus frozen sectioning methods, along with Masson’s trichrome versus hematoxylin and eosin (H&E) staining. These methods differ in processing time, tissue preservation, and the level of detail they reveal under a microscope. This project uses small intestines …

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Survival Of The Fittest: Extremophilic Actinomycetes As The Future Of Antibiotic Treatment, Ben Reddan, Kyley Nelson Apr 2026

Survival Of The Fittest: Extremophilic Actinomycetes As The Future Of Antibiotic Treatment, Ben Reddan, Kyley Nelson

Celebrating Scholarship and Creativity Day (2018-)

The antibiotic resistance crisis is an emerging global health threat. In 2019 alone, 1.27 million deaths were attributed to antibiotic-resistant pathogens, and researchers predict the problem will worsen without intervention. Methicillin-Resistant Staphylococcus aureus (MRSA) has become a primary model for this crisis because it utilizes genomic adaptations to bypass β-lactam antibiotics. Although temperate actinomycetes have historically provided the majority of clinical antibiotics, recent bioprospecting has revealed that extremophilic actinomycetes represent a critical untapped resource. These organisms exhibit several adaptations to thrive in extreme environments, which results in the production of novel secondary metabolites and resilient extracellular enzymes. This literature review …

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Food Insecurity On College Campus, Erika Islao, Izzy Green, Rachel Stone, Ariana Messer Apr 2026

Food Insecurity On College Campus, Erika Islao, Izzy Green, Rachel Stone, Ariana Messer

Celebrating Scholarship and Creativity Day (2018-)

Food Insecurity can affect certain groups more than others. At the College of Saint Benedict and Saint John's University we've observed it in international students, student-athletes, and those without transportation. Although CSBSJU offers several dining options, it can still be difficult for students to access meals due to limited availability during breaks, limited dining hours for student-athletes, and transportation barriers. This paper examines how food insecurity and nutrition insecurity impact students’ overall well-being while also exploring how these challenges appear within the CSBSJU community. Research shows that students experiencing food insecurity often report higher stress levels, and lower academic engagement. …

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The Impact Of Hybrid Insulin Peptides On The Two-Phase Decline Of C-Peptide In Type 1 Diabetes, Ashley Mehl Apr 2026

The Impact Of Hybrid Insulin Peptides On The Two-Phase Decline Of C-Peptide In Type 1 Diabetes, Ashley Mehl

Celebrating Scholarship and Creativity Day (2018-)

This research aims to determine how the formation of hybrid insulin peptides (HIPs) contributes to the two-phase decline of C-peptide production in type 1 diabetes (T1D). C-peptide is used to determine the level of insulin production within human pancreatic beta-cells because it is secreted in equimolar amounts with mature insulin peptide. The two-phase decline is characterized by an initial rapid and exponential loss of beta-cell function, followed by a prolonged plateau phase of residual insulin secretion. During this plateau phase, residual beta-cells continue to generate HIPs through both enzymatic transpeptidation and spontaneous formation via anhydride intermediates. These processes are problematic …

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Mechanistic Insights Into Enterolactone-Mediated Glut4-Dependent Glucose Uptake, Merritt Smith Apr 2026

Mechanistic Insights Into Enterolactone-Mediated Glut4-Dependent Glucose Uptake, Merritt Smith

Senior Honors Theses

Type 2 diabetes mellitus (T2D) is one of the leading causes of morbidity and mortality in the United States, with approximately 25% of healthcare expenditures directed toward its management and associated metabolic complications. In response to the urgent need for novel therapeutic strategies, recent research has focused on bioactive compounds derived from dietary sources. In light of that, we identified the plant lignan matairesinol (MA) and its gut-derived metabolite, enterolactone (ENL), as agents capable of enhancing glucose uptake in 3T3-L1 differentiated adipocytes. These results suggest that enterolactone may represent a promising dietary supplement for improving glycemic control in patients with …

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Psychedelic Research In The Modern Day: Good Or Bad?, Shane Miller Apr 2026

Psychedelic Research In The Modern Day: Good Or Bad?, Shane Miller

Mechanical Engineering Student Research

This work is about the usage/safety of psychedelic substances, and I explain whether they are good or bad in terms of other drugs, such as alcohol.

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Analysis Of The Flavonoid Composition Of Honey Using High-Performance Liquid Chromatography, Bryce Phillips Apr 2026

Analysis Of The Flavonoid Composition Of Honey Using High-Performance Liquid Chromatography, Bryce Phillips

Honors Theses

Honey is a naturally occurring substance that has a complex composition including compounds such as flavonoids, that contribute to potential health benefits. Quantitative analysis of flavonoids in honey can be challenging due to their similar structural characteristics, matrix effects, and chromatographic peak separation issues. This study aimed to establish calibration curves for five flavonoids–kaempferol, luteolin, chrysin, myricetin, and quercetin– to estimate their concentrations in five honey samples from varying geographic origins. Liquid-liquid extraction was used to isolate the flavonoids from honey. High Performance Liquid Chromatography was utilized to establish calibration curves and analyze honey samples. The calibration curves assembled demonstrated …

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Reinforcement Learning Improves Llm Accuracy And Reasoning In Disease Classification From Radiology Reports, Yishu Wei, Yi Lin, Adam Flanders, George Shih, Yifan Peng Apr 2026

Reinforcement Learning Improves Llm Accuracy And Reasoning In Disease Classification From Radiology Reports, Yishu Wei, Yi Lin, Adam Flanders, George Shih, Yifan Peng

Department of Radiology Faculty Papers

Accurate disease classification from radiology reports is essential for many applications. While supervised fine-tuning (SFT) of lightweight LLMs improves accuracy, it can degrade reasoning. We propose a two-stage approach: SFT on disease labels followed by Group Relative Policy Optimization (GRPO) to refine predictions by optimizing accuracy and format without reasoning supervision. Across three radiologist-annotated datasets, SFT outperformed baselines and GRPO further improved classification and enhanced reasoning recall and comprehensiveness.

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Time And Dose Dependent Effects Of Adipose-Derived Stromal Vascular Fraction Exosomes On Human Dental Pulp Stem Cell Proliferation, Sylva Dinie Alinda, Anggraini Margono, Indah Julianto, Dini Asrianti Bagio Apr 2026

Time And Dose Dependent Effects Of Adipose-Derived Stromal Vascular Fraction Exosomes On Human Dental Pulp Stem Cell Proliferation, Sylva Dinie Alinda, Anggraini Margono, Indah Julianto, Dini Asrianti Bagio

Journal of Dentistry Indonesia

Background: Cell proliferation is essential for tissue repair and immunomodulation in regenerative dentistry. Adipose-derived stromal vascular fraction (AD-SVF) is a promising autologous source for tissue engineering. Its exosomes (AD-SVF Exo), as cell-free products stable under ischemic conditions, represent an ethical and attractive modality for dental tissue regeneration and broader regenerative applications. Prior study indicates that AD-SVF Exo can enhance human dental pulp stem cell (hDPSC) migration and proliferation, particularly at low concentrations, but their detailed time- and dose-dependent proliferative effects remain unclear. This study aimed to investigate the time- and dose-dependent effects of low-concentration AD-SVF Exo on hDPSC proliferation …

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Evaluation Of Drug Use In Inpatient Care: A Retrospective Study At A Tertiary Hospital In Bandung, Indonesia (2024), Aliya Rosyidah Fitrianti, Athoya Delarosa, Husna Muharram Ahadi, Imam Adi Wicaksono, Falerina Puspita Apr 2026

Evaluation Of Drug Use In Inpatient Care: A Retrospective Study At A Tertiary Hospital In Bandung, Indonesia (2024), Aliya Rosyidah Fitrianti, Athoya Delarosa, Husna Muharram Ahadi, Imam Adi Wicaksono, Falerina Puspita

Pharmacology and Clinical Pharmacy Research

Rational drug use is a critical component of improving healthcare quality. However, irrational prescribing remains a significant concern, particularly in developing countries like Indonesia. This study evaluates drug use patterns at a Type B hospital in Bandung using WHO standard: average number of drugs per prescription, percentage of generic drugs, antibiotics, injections, and adherence to the National Formulary. A retrospective, descriptive observational method was applied, using 2024 inpatient Drug Use Evaluation (DUE) data. Findings reveal an average of 3.4 drugs per prescription—slightly above the WHO standard (≤ 3.3); 68.4% of prescriptions used generic drugs (meeting the WHO standard ≥ 59%); …

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Comparative Analysis Of The Quality Of Life Of Schizophrenic Patients On Antipsychotic Treatment Between Aripiprazole Monotherapy And Combination Of Risperidone-Clozapine At Mental Hospital In West Java, Taufiqurahman Taufiqurahman, Sani Asmi Ramdani Lestari, Ardilla Kemala Dewi Apr 2026

Comparative Analysis Of The Quality Of Life Of Schizophrenic Patients On Antipsychotic Treatment Between Aripiprazole Monotherapy And Combination Of Risperidone-Clozapine At Mental Hospital In West Java, Taufiqurahman Taufiqurahman, Sani Asmi Ramdani Lestari, Ardilla Kemala Dewi

Pharmacology and Clinical Pharmacy Research

Quality of life (QoL) is a critical outcome measure in schizophrenia management, yet antipsychotic side effects may negatively impact patients' well-being. Objective: This study aimed to compare the QoL of schizophrenia patients receiving aripiprazole monotherapy versus a risperidone-clozapine combination at West Java Mental Hospital. An analytical observational study with a cross-sectional design was conducted at the outpatient clinic of West Java Mental Hospital from March to May 2025. The Indonesian version of the WHOQOL-BREF questionnaire was used to assess QoL. A total of 58 outpatients with schizophrenia who met the inclusion criteria were enrolled, comprising 28 patients in the aripiprazole …

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Adherence To Malaria Treatment And Its Associated Factors: A Narrative Review, Lafie Urwatul Wutsqo, Eli Halimah, Sofa Dewi Alfian Apr 2026

Adherence To Malaria Treatment And Its Associated Factors: A Narrative Review, Lafie Urwatul Wutsqo, Eli Halimah, Sofa Dewi Alfian

Pharmacology and Clinical Pharmacy Research

Malaria is an infectious disease that remains a global health concern, particularly in Asia and Africa. The success of malaria medication largely depends on patients' adherence to the prescribed therapeutic regimen. This article aims to identify the level of adherence to malaria treatment and the factors that influence it, based on observational studies. A narrative review was conducted using the PRISMA approach, involving 12 articles published between 2019 - 2023 from various countries. The results indicate that adherence levels vary widely, ranging from 15.6% to 93.31%, depending on respondent characteristics and the intervention strategies implemented. Factors influencing adherence include patient-related …

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Patterns Of Adverse Drug Reactions In Tuberculosis Treatment: A Literature Review, Jasmine R. Aisyah, Ivan S. Pradipta, Widya N. Insani Apr 2026

Patterns Of Adverse Drug Reactions In Tuberculosis Treatment: A Literature Review, Jasmine R. Aisyah, Ivan S. Pradipta, Widya N. Insani

Pharmacology and Clinical Pharmacy Research

Tuberculosis (TB) treatment is often interrupted by adverse drug reactions (ADRs). However, few studies have thoroughly examined these ADR patterns in TB treatment, and no research has assessed the prevalence of ADRs in specific organs. This narrative review describes the patterns of ADRs in tuberculosis treatment, including how common each type is and its impact on organs across different countries and populations. A structured narrative literature review was conducted to identify relevant original studies published in PubMed database between 2019 and 2025. The search combined Medical Subject Headings (MeSH) and free-text terms related to ``tuberculosis'' and ``adverse drug reactions''. Eligible …

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Geospatial Assessment Of Agrivoltaic Opportunities And Land Use Requirements In Nigeria, Ifeoluwa Ezekiel Babarinde, Bashir Salisu, Jude A. Benavides, Engil Pereira, Steven M. Grodsky, Rafael M. Almeida Apr 2026

Geospatial Assessment Of Agrivoltaic Opportunities And Land Use Requirements In Nigeria, Ifeoluwa Ezekiel Babarinde, Bashir Salisu, Jude A. Benavides, Engil Pereira, Steven M. Grodsky, Rafael M. Almeida

School of Earth, Environmental, & Marine Sciences Faculty Publications

Agrivoltaics, the co-location of agriculture and solar photovoltaic (PV) infrastructure, can deliver co-benefits like reduced plant drought stress and improved yields of shade-tolerant crops, particularly in water-scarce regions. Despite growing global interest, the technical potential and opportunities for agrivoltaics remain poorly understood in many regions facing both food and energy insecurity, such as sub-Saharan Africa. Here we provide a spatial assessment of agrivoltaic opportunities in Nigeria by integrating cropland distribution, solar resources, and water stress. We find that northern states—where cropland is abundant and water-stressed, solar irradiance is high, and electricity access remains low—offer the greatest potential for agrivoltaic systems …

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Food Fortification Strategies To Address Micronutrient Deficiencies In Cambodia: A Scoping Review Of Policy Implementation, Industry Capacity, And Public Health Outcomes, Sokha Yem, Sreypeov Tun, Sokunthea Kem Apr 2026

Food Fortification Strategies To Address Micronutrient Deficiencies In Cambodia: A Scoping Review Of Policy Implementation, Industry Capacity, And Public Health Outcomes, Sokha Yem, Sreypeov Tun, Sokunthea Kem

Indonesian Journal of Public Health Nutrition (IJPHN)

Background: Micronutrient deficiencies remain a major public health challenge in Cambodia, with iron deficiency anaemia, iodine deficiency disorders, zinc deficiency, and vitamin A deficiency disproportionately affecting women of reproductive age and children under five. Food fortification—the deliberate addition of essential micronutrients to commonly consumed foods—has been widely recognised as a cost-effective population-level intervention to address nutritional gaps. Objective: To systematically map and synthesise existing evidence on food fortification strategies in Cambodia, focusing on policy implementation, industry production capacity and compliance, regulatory enforcement, and public health outcomes. Methods: A scoping review was conducted following the Arksey and O’Malley methodological framework and …

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