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Effects Of Normothermic Hepatic Ischemia–Reperfusion Injury On The Hepatic Disposition Of Arachidonic Acid And Its Cytochrome P450-Generated Metabolites In Rats, Vindhya Edpuganti, Reza Mehvar

Pharmacy Faculty Articles and Research

Purpose

Cytochrome P450 (P450) metabolites of arachidonic acid (AA) are potential therapeutic targets in ischemia–reperfusion (IR) injury, yet their disposition and actions in hepatic IR are unknown. Cellular AA and its P450 metabolites are primarily bound to lipid membranes, resulting in negligible free concentrations. This study investigates how hepatic IR injury impacts the disposition of free AA and its major P450 metabolites in rats.

Methods

Rats underwent 60 min of partial (70%) ischemia or sham surgery, followed by 5 min, 3 h, or 24 h of reperfusion. The effects of IR injury on free concentrations of AA and its major …

Lowland Tropical Forests Remain A Methane Sink Under Warming And Long-Term Hurricane Disturbance Recovery, Gabriele Larocca Conte, Lucia Zuvela, Rachel Cruz-Pérez, Tatiana Barreto-Vélez, Nibia Becerra-Santillan, Sophia F. Campbell, Hieu P. Chu, Trung Dam, Iana F. Grullón-Penkova, Miriam Kleit, Deyaneira A. Ortiz-Iglesias, Laura C. Rubio-Lebrón, Molly A. Cavaleri, Sasha C. Reed, Debjani Sihi, Tana E. Wood, Christine S. O'Connell

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

Methane (CH₄) is a potent greenhouse gas, and tropical forests account for roughly one–third of global atmospheric CH₄ uptake by soils. Projected warming and more frequent hurricanes in these ecosystems may alter soil CH₄ sink strength, as warmer and wetter soils enhance methanogenesis activity. We measured soil CH₄ and CO₂ efflux during the calendar summer months of 2023 and 2024 alongside continuous records of soil moisture, soil and air temperature, and precipitation in an in–situ warming experiment (TRACE) located in a lowland tropical forest in Puerto Rico, six to seven years after Hurricanes Irma …

Structure And Diversity Of Play Behavior In Juvenile Belding's Ground Squirrels, Paul O'Driscoll Ii

Master's Theses

Play behavior is ubiquitous among juvenile mammals and can promote motor, social, and cognitive development, providing multiple adaptive benefits to young animals in some cases. The structure of play can be linked to the benefits it confers on individuals. I evaluated the structure of play in juvenile Belding’s ground squirrels (Urocitellus beldingi), a species for which multiple adaptive benefits of play have been identified. I compared juvenile play in U. beldingi to adult sexual and aggressive behavior to determine and classify similarities between juvenile play and adult behavior. I evaluated diversity in the behaviors expressed during play interactions and diversity …

Improving Human-Wildlife Coexistence: An Ecological And Educational Approach To Rewilding Grizzly Bears (Ursus Arctos Horribilis) In California, Amanda C. D. Rosales

Master's Projects and Capstones

Megafauna extinction during the Holocene has been both caused and amplified by climatic changes and human influence. By the last half century, large carnivores were diminished in Europe and the United States, but policies increasingly addressed species decline and their territories expanded. This research examined large carnivore rewilding across the European Union and United States, specifically for rewilding brown bears, Ursus arctos, in historic habitat. Next, case studies for the health status of climate-impacted whitebark pine, Pinus albicaulis, a high energy food for bears, was assessed. Ultimately, research case studies, human perspective surveys, and the California Department of Education content …

Deforestation Dynamics In The Amazon: Impacts, Socio-Environmental Drivers And Restoration Pathways, Maria Natalia Rodriguez

Master's Projects and Capstones

The Amazon, which is the largest tropical rainforest in the world, experienced 542,581 km² of forest loss between the years 2000 and 2020. The process of deforestation endangers the ecological system results which maintain ecosystem connectivity and the Earth's climate system. The Amazon rainforest supplies essential ecological services which include maintaining soil fertility, storing carbon, purifying water and climate stability. The fundamental ecosystem of this area faces new threats because of increasing forest destruction. The research study adopts a combined methodology that uses Geographic Information Systems (GIS) with a comprehensive literature review to study Amazon deforestation patterns and its driving …

Examining The Ligands, Location, And Function Of Toll-Like Receptor 10, Kiefer Keanu Tam

Master's Theses

Toll-like receptors are a class of innate immune pattern recognition receptors that detect pathogen-associated molecular patterns and regulate downstream inflammatory responses. Toll-like receptor 10 remains the only human TLR whose ligand specificity, cellular localization, and immunological function are not fully defined. Emerging evidence suggests that TLR10 may play an anti-inflammatory role and can heterodimerize with TLR2 to modulate immune signaling. Previous studies from our laboratory demonstrated that stimulation with heat-killed Mycobacterium tuberculosis promotes TLR2-TLR10 heterodimerization and trafficking to the cell surface. In this study, we expanded our ligand panel to include additional gram-positive bacteria, particularly anti-inflammatory probiotic species, to further …

Investigating Cryptic Diversity In The Hawaiian Endemic Plant, Psychotria Mariniana (Rubiaceae), Uyen Thi Hoang Nguyen

Master's Theses

Islands, with their isolation and steep environmental gradients, serve as natural laboratories for studying speciation. Molecular phylogenetic and population genetic methods utilizing Next-Generation Sequencing (NGS) have revolutionized our ability to document patterns of genetic divergence and diversity. Cryptic diversity, genetically distinct populations that were previously unrecognized as unique, and cryptic speciation, where divergent genetic populations may be deserving of status as unique species, have been observed in many taxa. The Hawaiian Islands provide an ideal setting for studying divergence and speciation due to their extreme isolation, known ages, and volcanic origin. Previous work has investigated the evolutionary relationships of the …

Kev's Dinghy Boat Workshops, Ruiyang Xiao

Masters Theses

In a culture where convenience replaces process, this project argues that making — even when inefficient, imperfect, or unnecessary — enables forms of engagement that buying cannot.

Technologies and Services nowadays are able to fulfill human’s desire to travel and explore at ease. However, this convenience proposes a mode of engagement based only in deeper knowledge of context and thus our experience with the world around us is hence diminished. Our engagement with the world becomes heavily mediated, regulated and controlled.

This project investigates how hands-on engagement with water can reintroduce + restore our sense of joy, curiosity, consequence, and …

Replication And Architectural Enhancement Of Omni Aggregation Networks, Matteo Calviello

Rose-Hulman Undergraduate Research Publications

Single Image Super-Resolution (SISR) reconstructs high-resolution images from low-resolution inputs, a capability valuable across many application domains. This thesis focuses on the replication and architectural enhancement of the Omni Aggregation Network (OAN), a lightweight super-resolution architecture designed to balance reconstruction quality with computational efficiency through a novel omni-axis self-attention mechanism.

Independent replication remains a persistent challenge in machine learning research, and this work addresses that issue directly. Initial replication attempts trailed the original reported results by approximately 6-10% in performance metrics before several undocumented implementation details were identified. After correcting these discrepancies, the replicated implementation achieved results within 4% of …

Insects And Arthropods And Their Role In Human Society, Emily Marie Perez-Medina

Whittier Scholars Program

With brightly colored exoskeletons, an excess of both eyes and legs, and seemingly  unpredictable behaviors, insects and arthropods come across as unusual and strange to general audiences. For this reason, they are often classified as “gross,” “ugly,” or “scary,” antagonists  in popular culture. What is not recognized when being represented to the masses is how much human society depends on their presence, and how a world without insects would be a world without most things humans know and love. In order to help reduce the stigma of these tiny, yet mighty creatures, this project serves as a call to action …

Bat Species Acoustic Detections And Mist Net Captures 2017, 2018, 2019, 2022, 2023, 2025., Laroy Brandt

Faculty Peer-Reviewed Publications

No abstract provided.

Slouching Towards Inefficiency? The Cardiometabolic And Cognitive Costs Of Poor Posture, Ava Mae Fitzenrider

Honors Projects

Posture affects all of our lives. It is both static and dynamic, adapting continuously to environmental demands. One postural alteration frequently observed in occupational settings is hyperkyphosis, which can be induced by sitting position. During computer use, individuals commonly adopt a slouched posture, which can exacerbate hyperkyphosis, and contribute to dis-ease within the body. Previous research has demonstrated that such postural deviations can negatively affect pulmonary function, as well as other bodily functions. Despite these findings, the effects of acute hyperkyphosis (“slouching”) on cardiometabolic function and cognition remain largely unexplored. Therefore, the purpose of this study was to examine the …

Foveate, Dahlia Aggarwal

Masters Theses

This thesis investigates how textiles can unsettle visual assumptions, encouraging a perceptual shift. Through weaving, upholstery, and spatial installation, the work stages a tension between what a surface appears to be and how it is encountered by the body. Through woven pattern, tactile texture, and trompe l’oeil textile surfaces, perception is something negotiated rather than fixed: the eye anticipates one reality while the hand discovers another.

Drawing on a range of sensations gathered from observing landscape formations and textures, it translates enduring scale and material qualities into an interior landscape of woven surfaces and textile-based furniture. Rather than serving as …

Colonization Of Southern Flying Squirrels (Glaucomys Volans) To Urban Nebraska: Range Expansion Or Human Assisted Translocation?, Jennifer Wettschreck, James Wilson, Robert E. Wilson, Abby May, Megan Cary, Jeffrey Huebschman, Sarah A. Sonsthagen

Biology Faculty Publications

Southern flying squirrels (Glaucomys volans; Linnaeus 1758) were first observed in Lincoln, Nebraska, in 2018, 80 km north of their described range. Given that southern flying squirrels are a species of concern within Nebraska, determining the origin of this new population (natural expansion or pet-trade) garnered interest from state biologists. Further, the recent colonization of Lincoln by southern flying squirrels presents a unique opportunity to investigate the genetic implications of a founding event on a small arboreal mammal. The Lincoln population had genetic characteristics suggestive of a single-event colonization with fewer rare alleles and lower genetic diversity than potential …

The Marathon Without Running: Experiencing A Runner's Sensorial Journey, Harin Kim

Masters Theses

The marathon is defined not by motion alone, but by the changing conditions a body moves through—and remains within—over time. Breath, cadence, heat, sound, crowd compression and attention fluctuate, producing phases that structure the race from within. These interior states are difficult to access by spectators from the sidelines, yet they are precisely what shape the runner’s experience.

This thesis begins with a simple but unconventional question: How can an exhibition translate the runner’s physical sensations and emotions into a multidimensional experience for spectators who do not run? Through a sequence of pop-up exhibitions placed along the New York City …

Watershed Amendments: Assembling New Pervious Ground From Landscape Waste, Sophie Kaplan-Bucciarelli

Masters Theses

In Providence, Rhode Island, much of the downtown area is built over a vast historic tidal estuary. Though we no longer see the salt marshes, wooded bluffs, or meadows that once characterized this landscape, we recognize their absence in contemporary crises of urban heat, flooding, polluted soils and stormwater runoff, and habitat loss. These conditions are particularly acute along the city’s industrialized river corridors, where vacant lots and parking areas sit idle, their history paved over and potential constrained by limited imagination and resources.

These lots - already experiments in fill and land building after centuries of disturbance - can …

Somatic Prosthetics For Planetary Resonance, Disha Dharesh Kumar R

Masters Theses

This thesis investigates how industrial design can transcend extractive technological paradigms in favor of relational interfaces that foster planetary attunement. Framing the climate crisis as a 'crisis of imagination', the research challenges the Western bifurcation of nature and culture by drawing on Indic cosmologies- which recognize stones, plants, and ecosystems as conscious at different levels and participants in a shared cosmic field. By synthesizing research in Biosemiotics, Quantum Information Pansycishm, and Neuroscience, the project redefines intelligence as a distributed, more-than-human phenomenon.

The research materializes as a speculative design artifact: a device that functions as a somatic prosthetic for planetary resonance. …

Coenzyme Q10 Improves Functional And Structural Parameters Of Dairy Goat Sperm During Cooling And Cryopreservation, Ranadheer Narlagiri, Abdallah M. Shahat, Courtney Henry, Ashvini Pawar, Niki C. Whitley, Iman B. Shaheed, Mahipal Singh, Brou Kouakou, Irina A. Polejaeva, Adel R. Moawad

Animal, Dairy, and Veterinary Science Faculty Publications

Cryopreservation of gametes is crucial for conserving genetic diversity in livestock and endangered species, but the process can significantly impair sperm quality due to oxidative stress. Our aim was to evaluate the impacts of coenzyme Q10 (CoQ10) supplementation on the in vitro quality of cooled and cryopreserved goat semen. Semen samples collected from six mature Saanen bucks were pooled then diluted with AndroMed^® semen extender to a final concentration of 800 × 10⁶ sperm/mL. Diluted semen was supplemented with 0, 1, 2, 5, 10, and 20 µM CoQ10. Extended semen was either cooled at 4 °C for 72 …

Integrating Consumer-Grade Wearable Data Into Orthopedic Risk Stratification For Amateur Athletes: A Perspective On An Untapped Clinical Tool, Youssef Salama, William Gadbois, Kevin Reck, Scott Yaekle

Medical Student Research Symposium

Background:

Consumer-grade wearables have rapidly expanded beyond fitness tracking, providing continuous physiologic and biomechanical data. Metrics such as heart rate variability (HRV), sleep efficiency, and training load have been validated as markers of both recovery and overtraining. However, orthopedic care has not yet translated these data into clinical use. Given the rising burden of overuse injuries in recreational athletes, wearable-derived information may offer a practical opportunity for early detection and prevention within outpatient settings.

Methods:

A narrative perspective review of literature from 2010–2025 was performed using PubMed. Studies addressing wearable device validity, physiologic correlates of musculoskeletal injury, and training-load modeling …

Environmental Mercury Alters Immune Pathways Linked To Autoimmune Risk In Mice Mirroring Humans, Maurgan Lee, Paul Stemmer, Randall Gill, Allen Rosenspire, Anil Aranha, Heather Gibson

Medical Student Research Symposium

Background and Purpose: Mercury is a pervasive environmental contaminant, and human epidemiologic studies have linked chronic low-level exposure to increased autoimmune disease-risk. Dysregulated lymphocyte activation and impaired signaling tolerance are central mechanisms in human autoimmunity. Protein phosphorylation governs lymphocyte differentiation and function, alterations in phosphoproteomic networks may represent a signature of immune disruption. This study evaluates how low dose mercury exposure modifies B and T cell abundance and intracellular signaling patterns in BALB/c and Diversity Outbred (DO) mice.

Methods: BALB/c and DO mice were exposed to low dose HgCl2 in their water for two weeks or provided standard water controls. …

Effect Of Spry Of Potassium Ratio And Cycocel On Physiological Traits Of Maize (Zea Mays L), Asmaa Mohammed Hussein, Eabdallah Yasin Ali

AUIQ Complementary Biological System

The aim of this work was to investigating the effect of foliar application of potassium (K) and the growth regulator Cycocel (CCC) on the physiological traits of maize (Zea mays L). The experiment was designed using a split-plot arrangement within a randomized complete block design (RCBD) with three replicates. The treatments included foliar application of potassium at concentrations of 500, 1000, and 1500 mg.L^–1, as well as three concentrations of the growth regulator Cycocel (0, 150, and 200 mg.L^–1). The results indicated a significant increase in Protein (P), phosphorus, and carbohydrate contents at the concentration of …

Evolving Conservation: The Role Of Unconventional Approaches To Restore Contemporary Vertebrate Populations And Genomic Biodiversity, Bridgett M. Von Holdt, Matt James, Stephen J. Gaughran, Alexandra L. Decandia, Klaus-Peter Koepfli, Dan Flores, Nucharin Songsasen, Kristin Brzeski, Evelyn L. Jensen

Michigan Tech Publications

Conservation biology and restoration ecology are two essential yet distinct disciplines that address the growing challenge of biodiversity loss. Traditionally, these fields have relied on ecological principles and management practices aimed at protecting or reestablishing natural systems. The crisis is no longer just ecological it is evolutionary and genomic. The accelerating pace of environmental change has outstripped the capacity of conventional approaches, creating a pressing need for innovative solutions. Biotechnology offers potentially transformative tools that can enhance the effectiveness and precision of both conservation and restoration efforts, especially for species where conventional conservation approaches have proven insufficient. Techniques such as …

In Silico Molecular Docking Study Of Antidiabetic Bioactive Compounds From Brotowali (Tinospora Cordifolia) Targeting Glut4 In Type Ii Diabetes Mellitus, Gita Euaggelion Tarigan, Surya Dwira

Indonesian Journal of Medical Chemistry and Bioinformatics

Type 2 diabetes mellitus (T2DM) is a global metabolic disorder characterized by insulin resistance and impaired glucose uptake. Despite the availability of pharmacological therapies, limitations such as adverse effects and high costs highlight the need for alternative therapeutic candidates. Tinospora cordifolia has been widely reported to contain bioactive compounds with antidiabetic potential; however, comparative evaluation of their interaction with glucose transporter type 4 (GLUT4) remains limited.

This study aimed to identify the most promising bioactive compounds from Tinospora cordifolia targeting GLUT4 using an in silico molecular docking approach, followed by pharmacokinetic and toxicity (ADMET) prediction. Molecular docking was performed using …

Sustainable Choices, Generational Voices: Unraveling The Green Buying Behavior Of Millennials And Zoomers Using The Theory Of Planned Behavior, Bhadra Thulaseedharan Pillai, Aishwarya Nagarathinam, Shikha Bhagat, Senthilmurugan Paramasivan

Journal of Environmental Science and Sustainable Development

Younger generations have begun to change their purchasing behaviour in response to growing environmental concerns and global sustainability efforts. This research evaluates the eco-friendly shopping habits of Zoomers (born 1997–2012) and Millennials (born 1981–1996) in India. The research employs the Theory of Planned Behaviour (TPB) to analyse how the stewardship model, subjective norms, perceived consumer effectiveness, environmental attitudes and ecological values influence green product buying behaviour. A quantitative research design was adopted, and data were collected from 391 respondents across urban, semi-urban, and rural regions using a structured questionnaire. The relationship between the constructs were examined using structural equation modelling …

Soil Pests Of Corn, Francis Reay-Jones, Tim Bryant, Igor Schardong

Agronomic Crops

Corn rootworms, seed corn maggot, wireworms, and white grubs are sporadic insect pests of corn in the southeastern U.S. The immature stages of these species are subterranean, allowing them to feed on the roots of corn. The purpose of this publication is to provide growers, Extension agents, consultants, and other agricultural professionals an overview of the most common soil insect pests and how to control them.

Community-Based Participatory Research In Developing Online Nutrition Tools: A Pathway To Relevance And Engagement, Laura Justice, Stacy Phillips

EFNEP

This article explains how Community-Based Participatory Research (CBPR) can strengthen the design of digital nutrition tools by ensuring they are culturally relevant, accessible, and grounded in community needs. By engaging participants as equal partners, CBPR enhances trust, usability, and long-term impact. The approach aligns with EFNEP’s mission to deliver inclusive, community-driven nutrition education and provides a framework for developing sustainable, adaptable tools that reflect the lived experiences of the families Extension serves.

Exploring Biogeographical Ancestry Inference Of New York Residents Using A 45 Indel Panel, Amanda Martinez

Student Theses

Biogeographical ancestry (BGA) inference is an important tool in forensic science, providing supplemental information when comparison/reference DNA is not available for traditional DNA analyses. Insertion/deletion polymorphisms (INDELs) have been used in the last decade as ancestry-informative markers (AIMs) for BGA inference because they can be easily adapted to forensic-type samples and are determined using low cost and easy processing methods. Limited research has attempted to estimate ancestry and admixture in United States (U.S.) populations. This study evaluated the effectiveness of a 45- and 21- INDEL panel to measure population admixture proportions of four different origins (African, European, East Asian and …

Correlations Between The Army Combat Fitness Test (Aft) Events And The 12-Mile Ruck March, Isabella Huner Cruz

Masters Theses

The Army Fitness Test (AFT) consists of maximum deadlift, hand-release push-ups, sprint-drag-carry, plank, and a 2-mile run and is used by the United States Army to assess a soldier’s ability to meet occupational demands. The AFT is designed to ensure soldier readiness and maintain physical and mental well-being. In addition to the AFT, soldiers are often tasked with a loaded ruck march across various distances. Loaded ruck marches are a frequent occurrence in the Army as a mode of testing, training, and combat. Due to the AFT’s role in predicting soldier task performance, it would be valuable to identify any …

Do Cover Crops Influence Beneficial And Herbivorous Arthropod Communities Across Growing Seasons?, Adegboyega Fajemisin, Satinderpal Kaur, Alejandro Vasquez, Alexis Racelis, Rupesh R. Kariyat

School of Earth, Environmental, & Marine Sciences Faculty Publications

Cover crops provide multiple ecosystem services in agriculture, yet their influence on arthropod communities remains poorly understood, especially in commercial farming. Despite their potential benefits, it remains unexplored how cover crops affect arthropod community dynamics across multiple growing seasons. We conducted a two-year study across three commercial farms in the Lower Rio Grande Valley, Texas, to examine how cover crops influence arthropod community composition and abundance, whether beneficial arthropods (natural enemies and pollinators) persist into cash-crop phases, and how cover crops affect natural enemy–herbivore relationships. We compared arthropod communities between cover-crop treatments and control plots and tracked responses through subsequent …

Barn To Brain: Relationship Between Farm Animal Interaction And Well-Being In Rural Adults, Tiffany N. Hendershot

Doctoral Dissertations and Projects

This study examined the relationship between naturally occurring farm animal interactions and overall well-being among rural adults living in the central Appalachian region, specifically western Maryland, south-central Pennsylvania, and the eastern panhandle of West Virginia. A cross-sectional, correlational design was used to compare adults with at least five hours of naturally occurring farm animal contact per week to those with less than one hour of contact per week. Overall well-being was measured with the PERMA-Profiler, and heart rate variability (HRV) was measured using wearable devices as a physiological indicator of autonomic health. Grounded in polyvagal theory, the biophilia hypothesis, and …