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Articles 1411 - 1440 of 256340
Full-Text Articles in Entire DC Network
Natural Behavior Vs. Subjective Experience In Fish Welfare Assessments, Ronald G. Oldfield
Natural Behavior Vs. Subjective Experience In Fish Welfare Assessments, Ronald G. Oldfield
Animal Sentience
Several commentaries on the Oldfield & Bonano (2024) target article proposed that natural behavior should play a larger role in assessing the welfare of fishes in zoos and aquariums. However, the natural-behavior concept of animal welfare has been widely criticized because natural behaviors do not necessarily improve welfare, and unnatural behaviors do not necessarily reduce it. I review the three major concepts of animal welfare — physical health, natural behavior, and affect/feelings — and argue that behavior patterns, whether natural or otherwise, should be evaluated according to their effects on health and subjective experience. Using the affect/feelings concept and the …
Assessing The Effectiveness Of Wetland Reserve Easements As Habitat For Birds In The Mississippi Alluvial Valley Of Eastern Arkansas, Colin K. Dobson
Assessing The Effectiveness Of Wetland Reserve Easements As Habitat For Birds In The Mississippi Alluvial Valley Of Eastern Arkansas, Colin K. Dobson
Student Theses and Dissertations
Globally, wetland habitats suffered major declines during the 20th century. In the 1990s, the United States government created the Wetland Reserve Program (later consolidated into the Agricultural Conservation Easement Program), to combat the loss of wetlands. Despite success in attracting landowners, minimal monitoring of properties enrolled into the program (easements) has occurred. In this study, we monitored avian communities at easements, compared avian diversity at easements to agriculture and bottomland forests, and quantified microhabitat, site-specific, and surrounding landscape features at easements. We also studied the demographic rates of an indicator species of bottomland forests, the Prothonotary Warbler (Protonotaria citrea) at …
Enhancer Rna Transcription Near Segmentation Gene Enhancers Can Be Analyzed In Situ Using Fish, Christine Mau, Benjamin Schmid, Ezzat El-Sherif
Enhancer Rna Transcription Near Segmentation Gene Enhancers Can Be Analyzed In Situ Using Fish, Christine Mau, Benjamin Schmid, Ezzat El-Sherif
School of Integrative Biological & Chemical Sciences Faculty Publications
Enhancer RNAs (eRNAs) are non-coding transcripts produced at enhancer regions, which appear to be involved in transcriptional regulation. Up to date, these have been primarily investigated using labor- and cost-intensive genomic techniques. However, the precise mechanisms by which eRNA transcription or eRNA transcripts themselves mediate transcriptional regulation remain unclear. Here, we present a novel experimental approach that allows us to analyze characteristics of eRNA transcription in fixed and live whole Drosophila melanogaster embryos. We employ the anterior–posterior patterning genes as a model system to investigate the dynamics of eRNA expression, utilizing an imaging-based approach. We combined high-sensitivity fluorescence in situ …
Contribution Of Animals To Biomedical Advancements In The Current Era: A Narrative Review, Leena Rajathy Port Louis, Mani Rajarathinam, Prithiviraj Nagarajan, Divya Sekar, Nisha Perumal
Contribution Of Animals To Biomedical Advancements In The Current Era: A Narrative Review, Leena Rajathy Port Louis, Mani Rajarathinam, Prithiviraj Nagarajan, Divya Sekar, Nisha Perumal
The Thai Journal of Pharmaceutical Sciences
Animal research has played a major role in the development of vaccinations and therapies for illnesses such as tetanus, polio, meningitis, hepatitis, and Severe Acute Respiratory Syndrome Coronavirus 2. For every prescription drug available today, animal testing and research have contributed immensely. This narrative review aims to explore the contribution of animals to biomedical advancements in the current era, which involved a search of peer-reviewed literature using electronic databases such as Scopus, Web of Science, and PubMed. In current biomedical research, animals help develop new treatments for long-term illnesses such as cancer, HIV, and Alzheimer’s. Animals also aid in the …
Anti-Inflammatory Activities Of Muntingia Calabura L. In Monosodium Urate-Induced Acute Gout Arthritis: Regulation Of Nlrp3 And Il-1Β, Nita Parisa, Eva Rianty, Nia Savitri Tamzil, Debby Handayati Harahap, Veny Larasati, Bintang Arroyantri Prananjaya, Theodorus Theodorus
Anti-Inflammatory Activities Of Muntingia Calabura L. In Monosodium Urate-Induced Acute Gout Arthritis: Regulation Of Nlrp3 And Il-1Β, Nita Parisa, Eva Rianty, Nia Savitri Tamzil, Debby Handayati Harahap, Veny Larasati, Bintang Arroyantri Prananjaya, Theodorus Theodorus
The Thai Journal of Pharmaceutical Sciences
Background: Acute gout arthritis, which is caused by hyperuricemia, is a common inflammatory joint disease, leading to monosodium urate (MSU) crystal deposition. These crystals trigger inflammation, causing pain and significantly impairing the patient’s quality of life. Colchicine is commonly used to treat and prevent acute gout arthritis, but it has several side effects. Cherry tree (Muntingia calabura L.) leaves, which possess anti-inflammatory properties, show promise as an alternative treatment. The potential benefit of the leaves may be due to the flavonoid content.
Objectives: This study aimed to assess the anti-inflammatory activities of cherry tree leaves in an MSU-induced acute …
Adaptative And Structured Optimization Stockwell Transform For Robust Power-Quality Disturbances Detection, Moudjibatou Afoda, Séna Apeke, Filippo Gatti, Alessio Iovine, Léonce W. Tokam, Guy M. Toche Tchio, Ouro-Djobo S. Sanoussi
Adaptative And Structured Optimization Stockwell Transform For Robust Power-Quality Disturbances Detection, Moudjibatou Afoda, Séna Apeke, Filippo Gatti, Alessio Iovine, Léonce W. Tokam, Guy M. Toche Tchio, Ouro-Djobo S. Sanoussi
Mansoura Engineering Journal
The monitoring of electrical power quality requires advanced analysis techniques capable of accurately detecting and localizing non-stationary disturbances. This work proposes a structured and adaptive optimization of the Stockwell Transform (ST), referred to as Two-Power Optimization (TPO). A multiparametric Gaussian window governed by four parameters (m, p, k, r), is introduced, and a genetic algorithm is applied independently to each signal to optimize these parameters. The optimization process adapts the analysis scale to the local characteristics of the signal while preserving the physical consistency of the window function. Simulation results on synthetic power quality signals demonstrate that the proposed method …
Finite Element Modelling On A Non-Linear Radiative Hybrid Nanofluid Flowing Through A Rotating Disk, N. Janaki Phani Madhuri, Md. Shamshuddin
Finite Element Modelling On A Non-Linear Radiative Hybrid Nanofluid Flowing Through A Rotating Disk, N. Janaki Phani Madhuri, Md. Shamshuddin
Mansoura Engineering Journal
This study develops a finite element model to investigate the MHD flow and heat transfer phenomena of Cu–H₂O and Cu–Fe₃O₄–H₂O hybrid nanofluids flow across a spinning disk modelling by the Tiwari–Das model. The governing non-dimensional momentum and energy equations account for the effects of buoyancy, nonlinear radiation, and ohmic heating. The nonlinear coupled system is solved with the element method (FEM) to find the velocity and temperature fields. Parametric studies will investigate the effects of the magnetic field, buoyancy, volume fraction of nanoparticles, and radiation. Skin friction and Nusselt number are also reported. The results show that with the hybrid …
Real-Time Iot-Enabled Dissolved Oxygen Monitoring And Automated Wastewater Recirculation In Constructed Wetlands, Sivasankar Pandiarajan, Vanitha Sankararajan, Devarinti Chandu
Real-Time Iot-Enabled Dissolved Oxygen Monitoring And Automated Wastewater Recirculation In Constructed Wetlands, Sivasankar Pandiarajan, Vanitha Sankararajan, Devarinti Chandu
Mansoura Engineering Journal
Wastewater treatment is necessary for environmental conservation and combating water pollution. This study demonstrates real-time dissolved oxygen (DO) monitoring in constructed wetland treatment. The system would ensure an adequate supply of oxygen through automated water circulation whenever the level is below 4 mg/L, and shut down when it reaches the normal level. From experiments conducted, it was observed that within three automated circulation processes, it is possible to increase DO concentrations from 0.5 mg/L to 5.0 mg/L. Additionally, Total Dissolved Solids reduced from 1,380 ppm to 920 ppm. pH also stabilized from 8.38 to 7.9. In this system, data is …
Bridging Machine Learning And Climate Futures: A Framework For Explainable, Self-Directed (Agentic) Ai Models In Monitoring, Mitigation, And Governance Of Anthropogenic Climate Impacts, Vijayanandh Rajamanickam, Ketaki Kulkarni, Vishwanadham Mandala, Ozgur Kisi
Bridging Machine Learning And Climate Futures: A Framework For Explainable, Self-Directed (Agentic) Ai Models In Monitoring, Mitigation, And Governance Of Anthropogenic Climate Impacts, Vijayanandh Rajamanickam, Ketaki Kulkarni, Vishwanadham Mandala, Ozgur Kisi
Mansoura Engineering Journal
Environmental and societal damage due to anthropogenic climate change demands detection and mitigation strategies that are both effective and accountable. Machine Learning (ML) appears to offer a powerful set of tools but remains unexploited in these areas. A key barrier remains its poor ability to draw causal inferences about external systems, an essential requirement for meaningful continued monitoring, acting on, and shaping of the climate. Explainable, self-directed learned models operate by attributing environmental changes and deciding how best to model the resulting dynamics—they offer a natural solution. Recent developments in computational ecology, meteorology, and ML are combined to propose a …
Prediction Of Furniture Exports In Türkiye Using Machine Learning Methods, İlker Akyüz, Nadi̇r Ersen, Ti̇muçi̇n Bardak, Selahatti̇n Bardak
Prediction Of Furniture Exports In Türkiye Using Machine Learning Methods, İlker Akyüz, Nadi̇r Ersen, Ti̇muçi̇n Bardak, Selahatti̇n Bardak
Turkish Journal of Agriculture and Forestry
In this study, it was aimed to predict Türkiye’s furniture exports for the period from January 2010 to May 2025 using machine learning methods based on macroeconomic indicators. The dataset consisted of 10 economic variables, including the furniture industry production index, capacity utilization rate, import volume, total exports, real effective exchange rate, producer price index, money supply, and oil prices, with 185 observations per variable and a total of 2035 data points. During the data preprocessing phase, no missing or outlier values were detected, and the data were divided into 70% training and 30% testing subsets. Decision tree, random forest, …
Ozonated Water Delays The Microbial Growth And Sensory Quality Loss Of Capia Pepper Fruit During Cold Storage, Yasi̇n Şi̇mşek, Mehmet Ali̇ Koyuncu, Derya Erbaş
Ozonated Water Delays The Microbial Growth And Sensory Quality Loss Of Capia Pepper Fruit During Cold Storage, Yasi̇n Şi̇mşek, Mehmet Ali̇ Koyuncu, Derya Erbaş
Turkish Journal of Agriculture and Forestry
The aim of the present research was to evaluate, for the first time, the effect of ozonated water treatments on the postharvest quality of capia pepper (Capsicum annuum L. ‘Kaptan’). The peppers were harvested at the optimum time and transported to the laboratory immediately. Uniform and quality fruit was selected and precooled. After precooling, the fruit was divided into four groups. The first three groups were immersed in ozonated water at three different concentrations (1.0, 2.0 and 3.0 ppm) for 15 min. The last group (control) was immersed in distilled water for 15 min. The peppers were kept at room …
Interview With Orca Winner John Hibbing, Political Science; How Political Attitudes Correlate With Physiological Traits, Mark A. Griep, John Hibbing
Interview With Orca Winner John Hibbing, Political Science; How Political Attitudes Correlate With Physiological Traits, Mark A. Griep, John Hibbing
UNL ORCA Interview Series
Dr. John Hibbing was awarded the ORCA in 1993. John was born in 1953 in Paullina, Iowa. He earned a bachelor's in secondary education from Dana College in Blair, Nebraska, but then realized that teaching high school wasn't for him. Instead, he attended the University of Iowa, where he earned a master's and doctorate in political science. In 1981, he joined the University of Nebraska-Lincoln as an assistant professor of political science and rose quickly through the ranks. Initially, he studied the reasons that members of the U.S. Congress retire. This led to a longer-term collaboration with Kevin Smith and …
Investigating The Role Of Centromere Deletion In Chromosome Segregation, Azait Imtiaz
Investigating The Role Of Centromere Deletion In Chromosome Segregation, Azait Imtiaz
ETDs from 2020-2029
Centromeres are critical genomic regions responsible for ensuring accurate chromosome segregation during cell division. Disruptions in the structural or functional integrity of centromeric DNA could impair kinetochore assembly, leading to chromosome missegregation and chromosomal instability (CIN), a hallmark of various human diseases, including systemic sclerosis (SSc). This study investigated the contribution of centromeric DNA damage and deletion to CIN and explored potential pathogenic mechanisms relevant to SSc. We utilized hTERT-immortalized fibroblast cell lines (CHON-002 and BJ-5ta) to implement two complementary approaches: (i) treatment with bleomycin, a chemotherapeutic agent known to induce DNA double-strand breaks (DSBs), and (ii) targeted deletion of …
A Pilot Study Of The Acute Effects Of Isometric Exercise And Aerobic Exercise For Improving Blood Pressure And Vascular Hemodynamics In Hypertensive Adults, Ayih Cedric Edoh
A Pilot Study Of The Acute Effects Of Isometric Exercise And Aerobic Exercise For Improving Blood Pressure And Vascular Hemodynamics In Hypertensive Adults, Ayih Cedric Edoh
ETDs from 2020-2029
Hypertension (HTN) is one of the most prevalent and modifiable risk factors for developing cardiovascular disease (CVD). Aerobic exercise is a well-known method to lower blood pressure (BP), but recently, isometric exercise has been purported to lower BP to a similar or greater extent. There is little known about the effects of isometric exercise on acute BP and 24-hour ambulatory blood pressure (ABP). Therefore, the purpose of this pilot study was to compare the effects of isometric and aerobic exercise on improving vascular hemodynamics and 24-hour ABP in hypertensive adults. METHODS: Seven participants (age 25-65 years) with a diagnosis of …
Histone Deacetylases In Kidney Injury: Distribution, Injury-Specific Regulation, And Fibroblast Hdac1 Function, Huy Nguyen
ETDs from 2020-2029
Acute kidney injury (AKI) is increasingly recognized as a major contributor to the development of chronic kidney disease (CKD) through maladaptive repair and interstitial fibrosis. Epigenetic regulation has emerged as a critical factor of kidney injury responses, however the injury-specific and cell-type specific roles of histone deacetylases (HDACs) remain poorly defined. This dissertation investigates the regulation and functional significance of HDACs in kidney injury, with a particular focus on fibroblast HDAC1 as a mediator of interstitial fibrosis development following AKI. In my cisplatin-induced AKI model, a single dose of cisplatin caused a significant decline in kidney function in both male …
Small Rna Sequencing Identifies Tsrna-05020 As A Potential Regulator Of Cervical Cancer Progression, Cheng Peng, Cong Liang, Jie Liu, Yunlu Liu, Ping Liu
Small Rna Sequencing Identifies Tsrna-05020 As A Potential Regulator Of Cervical Cancer Progression, Cheng Peng, Cong Liang, Jie Liu, Yunlu Liu, Ping Liu
Turkish Journal of Biology
Background/aim: Cervical cancer (CC) is a malignant gynecologic tumor. Small RNAs derived from tRNA (tsRNAs) have been reported to play regulatory roles in tumor progression and suppression. However, the functional role of tsRNAs in CC remains largely unclear.
Materials and methods: Small RNA sequencing was performed on normal, cervical intraepithelial neoplasia (CIN), and CC clinical cell samples to identify differentially expressed tsRNAs (DEtsRNAs). qRT-PCR was used to validate the selected DEtsRNAs. The effects of tsRNA-05020 on HeLa cell proliferation, apoptosis, and epithelial-to-mesenchymal transition were assessed.
Results: Compared with the normal group, 215 tsRNAs were significantly differentially expressed in CIN tissues, …
An In Vitro Mechanistic Study Of Cholinergic-Associated Mechanisms Relevant To Masld In Hepg2 Cells, Gamze Sönmez, Müslüm Gök, Suat Sari, Ebru Bodur
An In Vitro Mechanistic Study Of Cholinergic-Associated Mechanisms Relevant To Masld In Hepg2 Cells, Gamze Sönmez, Müslüm Gök, Suat Sari, Ebru Bodur
Turkish Journal of Biology
Background/aim: Polyunsaturated fatty acids (PUFAs) and the hepatic cholinergic axis are critical regulators of lipid metabolism and inflammatory signaling; however, their time-dependent interplay in hepatocytes remains incompletely understood. Clarifying how n-6 and n-3 PUFAs interact with cholinergic pathways may provide mechanistic insight into metabolic dysfunction-associated steatotic liver disease (MASLD).
Materials and methods: HepG2 cells were used to examine the combined effects of butyrylcholinesterase (BChE) overexpression and PUFA exposure. Cells were treated with linoleic acid (LA; n-6) or α-linolenic acid (α-LA; n-3) for 24 or 48 h. Gene expression analyses were performed to assess pathways involved in de novo lipogenesis, β-oxidation, …
Pine Grosbeak (Pinicola Enucleator) Exhibit Collective Vocal Behavior During Foraging Bouts, Stefani A. Crabtree, Thomas J. Crabtree
Pine Grosbeak (Pinicola Enucleator) Exhibit Collective Vocal Behavior During Foraging Bouts, Stefani A. Crabtree, Thomas J. Crabtree
Environment and Society Faculty Publications
Pine Grosbeaks (Pinicola enucleator) are boreal finches whose winter ecology and social behavior remain only sporadically documented due to their remote distributions and irruptive dispersions. From 18 December 2023 to 6 March 2024, we conducted repeated daily observations of a flock of up to twelve P. Enucleator occupying a temporary wintering range in an urban neighborhood in Oregon. During these observations, we documented a previously undescribed collective vocalization associated with feeding. Comparison with 2674 archived Pine Grosbeak recordings from major bioacoustic repositories revealed that no clear matches between our recording and archives could be established. The low amplitude …
Context-Dependent Regulation Of Six1 By Ets1 Within Emt-Associated Transcriptional Networks, İrem Yalim Camci
Context-Dependent Regulation Of Six1 By Ets1 Within Emt-Associated Transcriptional Networks, İrem Yalim Camci
Turkish Journal of Biology
Background/aim: Epithelial-mesenchymal transition (EMT) is a fundamental process driving tumor plasticity, metastasis, and therapy resistance. Although E26 transformation-specific transcription factor 1 (ETS1) and Sine oculis homeobox homolog 1 (SIX1) are individually implicated in EMT-related transcriptional programs, the regulatory interplay and functional coordination of these proteins across tumor states remain unclear. Hence, this study aimed to investigate the mechanistic and clinical behavior of the ETS1–SIX1 axis, with a focus on hepatocellular carcinoma (HCC) and aggressive endothelial-like cancer phenotypes.
Materials and methods: ETS1–SIX1 expression patterns were analyzed using real‐time quantitative polymerase chain reaction in HCCderived cell lines and the endothelial-like SK-HEP-1 cell …
Retinoic Acid-Loaded Nanoparticles Enhance Macrophage-Mediated Control Of Leishmania Infantum, Zeynep İşlek, Merve Gündoğdu, Zeynep Di̇la Yüksel
Retinoic Acid-Loaded Nanoparticles Enhance Macrophage-Mediated Control Of Leishmania Infantum, Zeynep İşlek, Merve Gündoğdu, Zeynep Di̇la Yüksel
Turkish Journal of Biology
Background/aim: Visceral leishmaniasis, primarily caused by Leishmania infantum, remains a major global health challenge due to limitations in current chemotherapeutic options, including toxicity and emerging drug resistance. Host-directed therapeutic approaches are increasingly recognized as promising alternatives. All-trans retinoic acid (ATRA) is an immunomodulatory molecule with host-dependent effects on macrophage function; however, its therapeutic use is hindered by instability and poor solubility. Solid lipid nanoparticles (SLNs) offer a controlled and biocompatible delivery platform capable of enhancing intracellular drug accumulation.
Materials and methods: ATRA-loaded SLNs were prepared and characterized for size, polydispersity index, zeta potential, and morphology. Their antileishmanial activity was evaluated …
Characterization Of Poly-Β-Hydroxybutyrate And Its Biosynthesis In Priestia Endophytica Ucm B-5715, Alina Kharchuk, Maksym Kharchuk, Maksym Kharkhota, Sergiy Rogalsky, Oksana Tarasyuk, Oleksandr Kisten, Anastasiia Hubina, Illya Kapats, Liliia Avdieieva
Characterization Of Poly-Β-Hydroxybutyrate And Its Biosynthesis In Priestia Endophytica Ucm B-5715, Alina Kharchuk, Maksym Kharchuk, Maksym Kharkhota, Sergiy Rogalsky, Oksana Tarasyuk, Oleksandr Kisten, Anastasiia Hubina, Illya Kapats, Liliia Avdieieva
Turkish Journal of Biology
Background/aim: Polyhydroxyalkanoates (PHAs) are biodegradable biopolymers with promising applications in biotechnology and medicine; however, the diversity of their biosynthesis within the genus Priestia remains poorly characterized. Although Priestia species have been recognized as potential PHA producers, the detailed genomic architecture and physicochemical properties of the polymers synthesized by these bacteria, particularly in the type strain, remain poorly understood. This study aimed to characterize the poly-β-hydroxybutyrate (PHB) produced by Priestia endophytica UCM B-5715 and to investigate the PHB biosynthetic genes across related strains.
Materials and methods: PHB granules were visualized and measured using fluorescence microscopy, transmission electron microscopy, and scanning electron …
Nutrient Uptake Of Two Microalgae From Culture Medium Under Nickel Treatment, Di̇lara Erdaği, Büşranur Şeker, Celal Caner, Gi̇zem Çeti̇n, Hüseyi̇n Altundağ, Hati̇ce Tunca
Nutrient Uptake Of Two Microalgae From Culture Medium Under Nickel Treatment, Di̇lara Erdaği, Büşranur Şeker, Celal Caner, Gi̇zem Çeti̇n, Hüseyi̇n Altundağ, Hati̇ce Tunca
Turkish Journal of Biology
Background/aim: Phycoremediation is essential for purifying wastewater of heavy metals to ensure a sustainable environment, as these components can be detrimental to organisms upon entering the food chain. Among heavy metals, nickel is vital at low concentrations due to its presence in the active sites of many metalloenzymes in algae. However, at high concentrations, it disrupts the functioning of many metabolic reactions. This study examines the effects of nickel treatment on the uptake of macro- and micronutrients in medium by algae via ion exchange pathways or in competition with other metals. The study aims to determine the effects of nickel …
Describing Propagation Of Carbapenem-Resistant Acinetobacter Baumannii Through Comparative Genomics And Phenotypic Analysis Of Modern-Day Clinical Isolates, Emma Graffice
ETDs from 2020-2029
Understanding the genomic structure of bacterial populations is essential for tracking antimicrobial resistance and informing public health strategies to prevent spread of multidrug resistant organisms. In this study, we investigated the diversity and distribution of carbapenem-resistant Acinetobacter baumannii (CRAb) lineages across a major healthcare system in the U.S. Deep South through both retrospective and prospective isolate collection. Our analysis revealed a heterogeneous population composed of multiple genotypically and phenotypically distinct lineages. To improve the resolution of lineage classification, we applied average nucleotide identity (ANI) as a high-resolution metric for comparative genomics. A ≥99% ANI threshold effectively delineated lineages, outperforming traditional …
Contribution Of Phosphorylation To Hp1a Function, James Walts
Contribution Of Phosphorylation To Hp1a Function, James Walts
ETDs from 2020-2029
Heterochromatin Protein 1 (HP1) family members are highly conserved, non-histone chromosomal proteins essential for heterochromatin formation and transcriptional regulation. In Drosophila melanogaster, HP1a functions both as a transcriptional repressor and activator, as well as other functions, and undergoes post-translational modifications, including phosphorylation. The functional consequences of HP1a phosphorylation remain largely unexplored. This thesis investigates the role of phosphorylation at serines 89/90/91 (S899091) of HP1a by generating two mutant alleles: a phospho-mimic (SE) and a phospho-block (SA). Both alleles produce stable mRNA transcripts; however, Western blot analysis revealed reduced protein accumulation relative to wildtype HP1a. Homozygous phospho-block animals are embryonic lethal …
Jnk Signaling Impacts Car-T Cell Effector Function, Charles Kuhlmann
Jnk Signaling Impacts Car-T Cell Effector Function, Charles Kuhlmann
ETDs from 2020-2029
The potent cytotoxic activity of T cells serves as a natural defense against cancers. Chimeric antigen receptor (CAR) T cell therapy represents a strategy for harnessing T cells against advanced tumors. CAR-T cell therapy has seen striking success against hematologic malignancies, prompting its application to new diseases. Ovarian cancer is a highly lethal disease characterized by frequent recurrence and aggressive nature, prompting the investigation of CAR-T cell therapy as a salvage regimen. However, like in other solid tumors, the early performance of CAR-T cell therapy in ovarian cancer is poor. While many strategies exist for improving the longevity of CAR-T …
Epidemiology And Ultrasonographic Observations Of Urogenital Schistosomiasis Related Urinary Tract Morbidity In Itilima District, Simiyu Region, Tanzania, Coletha Yohana, Bruno A. Nyundo, Jared S. Bakuza, Peter F. Rambau, Safari M. Kinung’Hi
Epidemiology And Ultrasonographic Observations Of Urogenital Schistosomiasis Related Urinary Tract Morbidity In Itilima District, Simiyu Region, Tanzania, Coletha Yohana, Bruno A. Nyundo, Jared S. Bakuza, Peter F. Rambau, Safari M. Kinung’Hi
Tanzania Journal of Science
Chronic infection of urogenital schistosomiasis in humans is a major cause of urinary tract morbidity in endemic areas. However, information on the prevalence of schistosomiasisrelated urinary tract morbidity is lacking in most endemic countries including Tanzania. This study was conducted to determine the prevalence of schistosomiasis-related urinary tract morbidity in schoolchildren and adults in Itilima District. Urine samples from 682 residents were examined for Schistosoma haematobium infection using urine filtration technique. Urinary tract morbidity was examined by ultrasound. The prevalence of S. haematobium infection was 16.4% (112/682) and varied significantly between villages (range 3.2% to 29.5%, χ2 = 48.467, p < 0.001). There was no significant variation of S. haematobium infection between male and female (8.3 % vs 8.1%, χ2 = 0.679, p = 0.410). Majority (93.8%) had light infections (
Intrathecal (G4c2)149 Delivery In C9orf72-Deficient Mice Yields Mild Motor Dysfunction And Als/Ftd Pathological Hallmarks, Katelyn Russell, Amelia Shahrabi, Suleyman Akerman, Matthew D. Byrne, Jeffrey Rothstein, Davide Trotti, Brigid Jensen, Aaron Haeusler
Intrathecal (G4c2)149 Delivery In C9orf72-Deficient Mice Yields Mild Motor Dysfunction And Als/Ftd Pathological Hallmarks, Katelyn Russell, Amelia Shahrabi, Suleyman Akerman, Matthew D. Byrne, Jeffrey Rothstein, Davide Trotti, Brigid Jensen, Aaron Haeusler
Farber Institute for Neuroscience Faculty Papers
A repeat expansion in C9ORF72 is the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), yet existing mouse models incompletely engage spinal regions implicated in disease. Here, an adeno-associated virus encoding (G4C2)149 repeats was delivered via neonatal intrathecal injection, achieving widespread CNS expression with robust spinal cord targeting. This approach was applied to mice with graded loss of endogenous C9orf72 to interrogate both gain- and loss-of-function mechanisms. Longitudinal motor, behavioral, and pathological analyses revealed that repeat expression primarily drives mild, progressive muscle weakness, whereas coordination deficits were largely genotype dependent. Subtle gait abnormalities and hyperactivity …
Ameliorating Chromium-Induced Stress In Maize Through Phosphorus And Melatonin Application, Zunaira Zafar, Shoaib Ahmad, Muhammad Akhtar, Shafaqat Ali, Sarah Owdah Alomrani, Muhammad Ali Alshehri
Ameliorating Chromium-Induced Stress In Maize Through Phosphorus And Melatonin Application, Zunaira Zafar, Shoaib Ahmad, Muhammad Akhtar, Shafaqat Ali, Sarah Owdah Alomrani, Muhammad Ali Alshehri
Turkish Journal of Agriculture and Forestry
Chromium (Cr+6) toxicity is a significant environmental stress factor that severely hampers plant growth and productivity. This study aimed to evaluate whether the combined application of phosphorus fertilizer and melatonin could alleviate chromium induced stress in maize (Zea mays L.). A foliar spray of melatonin (50 µM) was applied alongside two phosphorus sources—phosphoric acid (PA) and diammonium phosphate (DAP), each at 60% of the recommended rate. Two maize cultivars (FH-1046 and YH-1898) were grown under chromium stress (0, 15, and 30 mg kg–1) to assess treatment effects. The results demonstrated that FH-1046 plants treated with PA + melatonin under noncontaminated …
Unveiling Resistance Mechanisms To Fusarium Wilt Through Comparative Transcriptome Analysis Of Cicer Arietinum And Cicer Reticulatum, Özlem Tuna, Yasi̇n Kaymaz, Talap Talapov, Canan Can, Muhammed Bahatti̇n Tanyolaç, Duygu Ateş
Unveiling Resistance Mechanisms To Fusarium Wilt Through Comparative Transcriptome Analysis Of Cicer Arietinum And Cicer Reticulatum, Özlem Tuna, Yasi̇n Kaymaz, Talap Talapov, Canan Can, Muhammed Bahatti̇n Tanyolaç, Duygu Ateş
Turkish Journal of Agriculture and Forestry
Developing resistant chickpea cultivars is essential for managing Fusarium wilt caused by Fusarium oxysporum, a major pathogen responsible for substatial yield losses. In this study, we conducted RNA-seq–based transcriptome analysis to characterize gene expression changes in resistant and susceptible genotypes of Cicer arietinum L. and C. reticulatum following inoculation with Fusarium oxysporum f. sp. ciceris race 0. Susceptible genotypes exhibited markedly higher numbers of differentially expressed genes compared with resistant genotypes. Defense-related genes were induced in all plants upon infection; however, resistant genotypes specifically upregulated genes functioning in the apoplast or extracellular region while downregulating intracellular processes—a pattern not observed …
The Change Of Yield, Growth, And Fruit Quality In Rubygem Strawberry Using Arbuscular Mycorrhizal Species, Selma Kuru Berk
The Change Of Yield, Growth, And Fruit Quality In Rubygem Strawberry Using Arbuscular Mycorrhizal Species, Selma Kuru Berk
Turkish Journal of Agriculture and Forestry
Arbuscular mycorrhizal fungi (AMF), which exist symbiotically with plant roots, affect plant growth, yield, and fruit quality. The effects of AMF vary depending on the cultivar and mycorrhizal type. In this study, the effects of different AMF types on the Rubygem strawberry cultivar, widely grown in Türkiye, were examined. Gigaspora margarita and Funneliformis mosseae AMF species were applied to plant roots at seedling planting. Fruit quality criteria, including yield, acidity, soluble solid content, phenolic compounds, organic acids, crown and root development, and the number of daughter plants and stolons, were examined. The highest yield was 431.02 g in G. margarita. …