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Articles 751 - 780 of 108564
Full-Text Articles in Entire DC Network
Prediction Model Of Green Grape Water Loss Rate Based On Multi-Model Soft Voting Fusion, Fan Gai, Jing Min, Ji Feng, Ma Maosen, Yao Xiaomin
Prediction Model Of Green Grape Water Loss Rate Based On Multi-Model Soft Voting Fusion, Fan Gai, Jing Min, Ji Feng, Ma Maosen, Yao Xiaomin
Food and Machinery
[Objective] This study aims to achieve rapid and non-destructive detection of the water loss rate in green grapes, control losses, and ensure quality. Based on an LED-induced fluorescence spectroscopy system, a prediction method combining collected spectral data with a multi-model soft voting fusion approach was proposed for green grape water loss rate estimation. [Methods] Spectral data from 100 green grape samples were collected. Preprocessing was performed using multivariate scatter correction (MSC), standard normal variate transformation (SNV), normalization, and Savitzky–Golay (SG) filtering. Feature wavelength selection was carried out using the successive projections algorithm. Based on this, prediction models for the green …
Screening Of Weizmannia Coagulans With High Stress Tolerance, Xiao Xue, Yu Wendi, Hu Yuanliang, Zhang Xicai, Yu Xiang
Screening Of Weizmannia Coagulans With High Stress Tolerance, Xiao Xue, Yu Wendi, Hu Yuanliang, Zhang Xicai, Yu Xiang
Food and Machinery
[Objective] To isolate and screen novel Weizmannia coagulans strains with high stress tolerance. [Methods] Using commercially fermented pickle brine as the sample, W. coagulans strains were isolated, purified, and identified by selective culture medium methods, morphological observation, physiological and biochemical characterization, and 16S rDNA sequencing. Taking survival rate as the evaluation index, the stress tolerance of the isolated strains and three laboratory-preserved W. coagulans strains was determined under high-temperature (80–100 ℃), acidic (pH 2.0–3.0), and bile salt (0.1%–0.5%) conditions. Principal component analysis (PCA) was applied to comprehensively assess the stress tolerance of the tested strains. [Results] Two W. coagulans strains, …
Effects Of Pretreatment Methods On Volatile Compounds And Active Ingredients In Flaxseed Oil, Zhu Lijun, Chen Fengzhen, Zhang Chengshuang, Zhao Baoyi, Meng Lingjun
Effects Of Pretreatment Methods On Volatile Compounds And Active Ingredients In Flaxseed Oil, Zhu Lijun, Chen Fengzhen, Zhang Chengshuang, Zhao Baoyi, Meng Lingjun
Food and Machinery
[Objective] This paper aims to investigate the effects of microwave and roasting pretreatment methods on volatile compounds and active ingredients in flaxseed oil. [Methods] Flaxseeds were pretreated by microwave (720 W, 2–8 min) and roasting (140–200 ℃, 30 min), and then flaxseed oil was prepared by cold pressing. Using untreated cold-pressed flaxseed oil as a control, the differences in volatile compounds were analyzed by headspace gas chromatography–ion mobility spectrometry (HS-GC-IMS) and an electronic nose. Additionally, the contents of tocopherols, phytosterols, and total phenolics were determined. [Results] A total of 72 volatile compounds are identified by HS-GC-IMS analysis, including aldehydes (20 …
Strategy For Linear Range Broadening Of Elisa Based On Antibody Synergistic Combination, Guo Cuili, Peng Juan, Lai Weihua, Xing Keyu, Gan Bei
Strategy For Linear Range Broadening Of Elisa Based On Antibody Synergistic Combination, Guo Cuili, Peng Juan, Lai Weihua, Xing Keyu, Gan Bei
Food and Machinery
[Objective] To broaden the linear range of ELISA for deoxynivalenol detection. [Methods] This paper obtains three antibodies with different sensitivities via mouse immunization, cell fusion and screening, ascites preparation, and antibody purification. By optimizing the working concentration and composition ratio of the antibody synergistic combination, the optimal antibody synergistic combination ratio is applied to ELISA to determine the linear range. [Results] The optimal reaction conditions for the ic-ELISA based on synergistic antibodies are as follows: the optimal working concentrations of the coating antigen and antibody are 0.3 and 0.1 μg/mL, respectively. The linear range of the synergistic antibody is obviously …
Quantitative Analysis Of Sorghum Starch Using Machine Learning And Near-Infrared Spectroscopy, Li Ke, Ouyang Runkun, Dai Yijie, Li Jie, Hou Aixiang, Yang Yu, Li Zongjun
Quantitative Analysis Of Sorghum Starch Using Machine Learning And Near-Infrared Spectroscopy, Li Ke, Ouyang Runkun, Dai Yijie, Li Jie, Hou Aixiang, Yang Yu, Li Zongjun
Food and Machinery
[Objective] To establish a model for the rapid quantification of sorghum starch based on near-infrared spectroscopy and machine learning algorithms. [Methods] Brewing sorghum was used as the raw material. Near-infrared diffuse reflectance spectra were collected using a near-infrared spectrometer. The Isolation Forest algorithm was employed to remove outlier samples and optimize the dataset. Subsequently, multiple preprocessing methods and regression models were compared using various modeling software to analyze and establish a quantitative model for sorghum starch. [Results] After preprocessing with the Isolation Forest algorithm, the partial least squares regression (PLSR) model exhibited the best performance, with a coefficient of determination …
An Ai-Driven Safety Traceability And Monitoring System For Food Cold Chain, Zeng Xiaoqing, Zhang Yuyue, Xie Wenqing, Zhou Jianhua
An Ai-Driven Safety Traceability And Monitoring System For Food Cold Chain, Zeng Xiaoqing, Zhang Yuyue, Xie Wenqing, Zhou Jianhua
Food and Machinery
Targeting the three major obstacles—information fragmentation, delayed risk response, and ambiguous accountability—in food cold chain safety governance, this study constructs an integrated cold chain safety traceability and monitoring system centered on artificial intelligence technology and incorporating the Internet of Things and blockchain. On the basis of a comprehensive risk analysis of the entire food cold chain process, and drawing on theoretical frameworks including supply chain resilience theory, information asymmetry theory, HACCP, and ISO 22000 food safety standards, this study designs a system architecture organized around five functional modules: multi-source data collection and traceability, dynamic food quality assessment, risk prediction and …
Terminal Control Method Of Parallel Food Sorting Robot With Multi-Algorithm Fusion, He Qing, Wu Tianfeng, Zhao Yini
Terminal Control Method Of Parallel Food Sorting Robot With Multi-Algorithm Fusion, He Qing, Wu Tianfeng, Zhao Yini
Food and Machinery
[Objective] To address the problems of low trajectory tracking accuracy, delayed dynamic response, poor adaptability to external disturbances, and difficulty in meeting the requirements of high-speed and high-precision food sorting in the existing end-effector control of parallel food sorting robots. [Methods] A food sorting system based on a DELTA parallel robot was developed, and an end-effector control strategy integrating an improved whale optimization algorithm, adaptive fuzzy control, and nonsingular fast terminal sliding mode control was designed. Adaptive fuzzy control was used to adjust the output gain in real time to enhance controller tracking accuracy. The improved whale optimization algorithm was …
Effect Of Double-Bin Plansifter Motion Parameters On Sieving Efficiency, Li Shuang, Wang Fengcheng, Deng Xiangzhi, Li Xinze, Zhang Baowei, Fu Yunfeng, Xue Chunzhi
Effect Of Double-Bin Plansifter Motion Parameters On Sieving Efficiency, Li Shuang, Wang Fengcheng, Deng Xiangzhi, Li Xinze, Zhang Baowei, Fu Yunfeng, Xue Chunzhi
Food and Machinery
[Objective] The aim is to explore the effect of double-bin plansifter motion parameters on the material sieving efficiency of different systems after wheat milling. [Methods] The milled materials produced by the break system, tailing roll, and scratch system, obtained from a typical milling production line, were selected as raw materials. The double-bin plansifter was used to sieve different materials to investigate the variations in residence time inside the sieve body and in sieving performance under different motion parameters of milled materials in each system. The motion parameters with the optimal sieving performance for the milled materials from each system were …
Extraction Optimization For Polyphenols From Clausena Anisum-Olens Kernel , As Well As Their Antioxidant And Antibacterial Activities, Liao Jianhong, Su Xiufang, Zheng Guangjin, Li Ganghui
Extraction Optimization For Polyphenols From Clausena Anisum-Olens Kernel , As Well As Their Antioxidant And Antibacterial Activities, Liao Jianhong, Su Xiufang, Zheng Guangjin, Li Ganghui
Food and Machinery
[Objective] To optimize the extraction process of polyphenols from Clausena anisum-olens kernel, and to analyze their in vitro antioxidant and antibacterial activities. [Methods] With ultrasonic temperature, power, time, as well as solid–liquid ratio and ethanol volume fraction as experimental factors, the response surface method was employed to optimize the ultrasonic extraction process of polyphenols from C. anisum-olens kernel. Furthermore, the in vitro antioxidant activity of the polyphenols was investigated via free radical scavenging assays, and the antibacterial activity was determined using the well diffusion method. [Results] The optimal extraction process is an ultrasonic power of 94 W, an ultrasonic time …
Ameliorative Effects And Mechanisms Of Crocetin On Insulin Resistance In High-Fat Diet-Induced Diabetic Mice, Wen Jing, Qin Si, Lyu Chenghao
Ameliorative Effects And Mechanisms Of Crocetin On Insulin Resistance In High-Fat Diet-Induced Diabetic Mice, Wen Jing, Qin Si, Lyu Chenghao
Food and Machinery
[Objective] To investigate the hypoglycemic, lipid-lowering, anti-inflammatory, and antioxidant effects of crocetin in high-fat diet (HFD)-induced diabetic mice, and to preliminarily explore its regulatory effects on hepatic insulin signaling pathways and protein S-nitrosylation levels. [Methods] An insulin resistance model was established in C57BL/6J mice by HFD feeding. Mice were administered low (5 mg/kg), medium (10 mg/kg), or high (20 mg/kg) doses of crocetin for 8 weeks, with metformin (200 mg/kg) used as a positive control. Fasting blood glucose, oral glucose tolerance, serum insulin, lipid profiles, hepatic oxidative stress, and inflammatory cytokines were measured. Western blot was used to detect phosphorylation …
Comparative Analysis Of Beef Quality From Bashan Region, Wan Xiaohui, Yao Pingbo, Zhang Duoduo, Ma Xiaowen, Tang Youxue, Liu Yongfeng
Comparative Analysis Of Beef Quality From Bashan Region, Wan Xiaohui, Yao Pingbo, Zhang Duoduo, Ma Xiaowen, Tang Youxue, Liu Yongfeng
Food and Machinery
[Objective] To clarify the unique quality of beef from the Bashan region. [Methods] Xizhen cattle beef from the eastern, southern, south-central, central, and northern regions of Zhenba County, Shaanxi Province, is taken as the material to investigate the differences in nutritional quality (moisture, protein, fat, and minerals) and eating quality (color, texture, and flavor). [Results] Zhenba beef has unique qualities, such as high protein and total mineral content, compared with the nutrient composition of beef in the food nutrient composition database published by the National Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention. For nutritional quality, …
Comparison And Optimization Of Glycoprotein Extraction Processes For Six Panax Medicinal Herbs Using Ultra-High Pressure Extraction Technology, Chang Fangyu, Zang Hao, Cheng Liye, Han Lusheng, Du Lianyun, Wang Enpeng
Comparison And Optimization Of Glycoprotein Extraction Processes For Six Panax Medicinal Herbs Using Ultra-High Pressure Extraction Technology, Chang Fangyu, Zang Hao, Cheng Liye, Han Lusheng, Du Lianyun, Wang Enpeng
Food and Machinery
[Objective] To comprehensively compare and screen glycoprotein preparation processes for six representative medicinal materials from the genus Panax. [Methods] Glycoprotein yield, DPPH radical scavenging capacity, hydroxyl radical scavenging capacity, and Fe2+ chelation inhibition rate were used as evaluation indicators. Glycoprotein extraction rates and antioxidant activities of six medicinal materials, including P. ginseng, P. notoginseng, P. quinquefolius, P. japonicus (T. Nees) C. A. Mey., P. stipuleanatus H. T. Tsai & K. M. Feng, and P. bipinnatifidus Seem, were compared using traditional thermal extraction and ultra-high pressure processing (UHPP). The Box–Behnken response surface method was employed to optimize UHPP parameters for P. …
Effect Of Modified Hemoglobin As A Substitute For Sodium Nitrite On The Quality Of Ham Sausage, Qu Shulei, Ma Chao, Yao Xianqi, Du Dongxu, Wang Wei, Liu Yunguo
Effect Of Modified Hemoglobin As A Substitute For Sodium Nitrite On The Quality Of Ham Sausage, Qu Shulei, Ma Chao, Yao Xianqi, Du Dongxu, Wang Wei, Liu Yunguo
Food and Machinery
[Objective] To improve the utilization rate of porcine blood and the safety of ham sausage. [Methods] Under specific conditions, hemoglobin in porcine blood is modified to produce glycosylated nitrosohemoglobin (GN-Hb). Different amounts of GN-Hb are added to replace sodium nitrite in heat-treated ham sausages. The quality characteristics of the sausages are evaluated through texture analysis, nutritional testing, color difference assessment, color acceptability, elasticity, chewiness, and overall acceptability. [Results] When the sodium nitrite dosage is 100 mg/kg and the GN-Hb dosage is 2.5 g/kg, high-temperature sterilized ham sausage containing the new pigment shows significant improvement in color and cohesion compared with …
Optimization Of Probiotic Fermentation Process And Effects Of Drying Methods On The Quality Of Sea Buckthorn Leaves, Dong Xiaoyue, Yun Xueyan, Zhang Lu, Dong Tongliga, Zhao Chenxi, Te Jinwei, Wang Xiukuan, Hao Qian, Miao Meishu, Su Ke
Optimization Of Probiotic Fermentation Process And Effects Of Drying Methods On The Quality Of Sea Buckthorn Leaves, Dong Xiaoyue, Yun Xueyan, Zhang Lu, Dong Tongliga, Zhao Chenxi, Te Jinwei, Wang Xiukuan, Hao Qian, Miao Meishu, Su Ke
Food and Machinery
[Objective] To investigate the effects of probiotic fermentation conditions and drying methods on the quality of fermented sea buckthorn leaf products. [Methods] Lactiplantibacillus plantarum is used for fermentation. The fermentation process of sea buckthorn leaves is optimized through single-factor experiments combined with response surface methodology. Fermented sea buckthorn leaf extract is prepared under the optimal fermentation conditions and subsequently processed into freeze-dried powder by direct freeze-drying and spray freeze-drying, with or without low-voltage electrostatic field assistance. The effects of different treatments on viable cell counts, flavonoid and polyphenol retention rates, water activity, and in vitro digestion characteristics are evaluated. [Results] …
Extraction Process Optimization Of Camellia Sinensis Flavonoids And Their Antioxidant Activity, Tu Jianqiu, Xu Danhe, Chen Long, Wang Yaxin, Xu Jiahui, Jing Lixiang, Li Jianfang
Extraction Process Optimization Of Camellia Sinensis Flavonoids And Their Antioxidant Activity, Tu Jianqiu, Xu Danhe, Chen Long, Wang Yaxin, Xu Jiahui, Jing Lixiang, Li Jianfang
Food and Machinery
[Objective] To optimize the extraction process of flavonoids from Xinyang Camellia sinensis and to compare the in vitro antioxidant activities of total flavonoids before and after purification. [Methods] Using Xinyang C. sinensis as raw material, a one-factor test is conducted to investigate the effects of ethanol volume fraction, ultrasonic time, ultrasonic power, and material–liquid ratio on the yield of flavonoids. Subsequently, a three-factor, three-level optimization model is established based on the Box–Behnken experimental design. Additionally, a macroporous adsorption resin is utilized for the purification of flavonoid crude extracts. Finally, the in vitro antioxidant activity of the total flavonoids is evaluated …
Research Progress On Tubular Chain Conveyors And Their Applications In The Grain, Oil And Food Industry, Wu Weiwei, Xia Chaoyong, Sui Sai
Research Progress On Tubular Chain Conveyors And Their Applications In The Grain, Oil And Food Industry, Wu Weiwei, Xia Chaoyong, Sui Sai
Food and Machinery
Tubular chain conveyors have become core equipment in modern bulk material handling by virtue of their significant advantages, including highly efficient conveying, fully enclosed operation, and three-dimensional flexible spatial layout. This paper systematically reviews the current status and progress of research on tubular chain conveyors both domestically and internationally, and provides an in-depth analysis of their technological evolution, core theoretical framework, and industrial adaptability. Emphasis is placed on reviewing their engineering applications in the grain, oil, and food industry. In view of the remaining deficiencies in current research concerning adaptability to extreme operating conditions, multi-physics coupling mechanism modeling, large-scale implementation …
Progress On The Nutrient Components, Functional Activities, And Utilization Of Dictyophora Rubrovalvata, Zhang Lunqing, Wang Xianxing, Li Qiaoqiao, Xu Cunbin, Wang Yu
Progress On The Nutrient Components, Functional Activities, And Utilization Of Dictyophora Rubrovalvata, Zhang Lunqing, Wang Xianxing, Li Qiaoqiao, Xu Cunbin, Wang Yu
Food and Machinery
Dictyophora rubrovalvata, a valuable edible fungus in China, is rich in active components such as polysaccharides, proteins, amino acids, and vitamins, exhibiting significant efficacy in antioxidant, anti-fatigue, antitumor, immunomodulatory, hepatoprotective, and anti-inflammatory activities. This paper systematically reviews recent research progress on the nutritional components, functional activities, and utilization status of D. rubrovalvata, both in China and elsewhere, with an outlook on its future development directions and application prospects.
A Review Of Metabolic Mechanisms Of N-Nitroso Compounds And Measures For Their Reduction And Control, Wang Zhulin
A Review Of Metabolic Mechanisms Of N-Nitroso Compounds And Measures For Their Reduction And Control, Wang Zhulin
Food and Machinery
N-nitroso compounds, as one of the major food contaminants, are widely present in food and pose hazards such as carcinogenicity, teratogenicity, and mutagenicity, thus being a key focus in food safety monitoring. Although significant progress has been made in the research on N-nitroso compounds, studies on their metabolic mechanisms and reduction and control measures are still disconnected to a certain extent. Through a review of the classification, detection methods, and toxic effects of N-nitroso compounds, this article analyzes the intrinsic connection between their metabolic pathways in the body and strategies for external reduction and control, aiming to provide theoretical references …
Consumer Judgment, Choice, And Meaning-Making In Food Packaging Design From The Perspective Of Consumption Alienation, Guo Jingzhi, Xu Ming
Consumer Judgment, Choice, And Meaning-Making In Food Packaging Design From The Perspective Of Consumption Alienation, Guo Jingzhi, Xu Ming
Food and Machinery
In the context of contemporary food consumption, food packaging has gradually shifted from a tool for product protection and information transmission to an important cognitive interface that influences consumer perception, judgment, and choice. Existing studies in this field mainly focus on functional optimization, behavioral guidance, and cultural expression, while insufficient attention has been paid to how packaging design affects consumer cognitive processes. This paper introduces the theoretical perspective of consumption alienation and employs literature analysis and comparative case studies to construct a three-layer analytical framework of “judgment–choice–meaning.” Furthermore, it proposes a regression-based analytical pathway centered on comprehensibility, choice support, and …
Sustainable Design Strategies For Regional Food Packaging Based On The Dual Circulation Of Matter And Culture, Jin Yuhan, Wang Chao, Hou Zhigang
Sustainable Design Strategies For Regional Food Packaging Based On The Dual Circulation Of Matter And Culture, Jin Yuhan, Wang Chao, Hou Zhigang
Food and Machinery
In response to the current focus on material circulation in regional food packaging research and the lack of mechanisms for the dissemination of regional culture, this study explores a sustainable design pathway for the coordinated development of cultural and material circulation in the context of new retail. Taking a high-end apple gift box as a practice-based validation object, a dual-circulation packaging system integrating material and cultural circulation was constructed and validated from four aspects, i.e., material selection, structural innovation, visual narrative, and interactive experience, based on the triple bottom line (TBL) and cradle-to-cradle (C2C) theories. The use of locally sourced …
Design, Fabrication, And Performance Evaluation Of A Recycling Machine For Converting Biodegradable Waste Into Compost, Mohamed T. Eraky, M.M Radwan, Abdelkhalik Eladl
Design, Fabrication, And Performance Evaluation Of A Recycling Machine For Converting Biodegradable Waste Into Compost, Mohamed T. Eraky, M.M Radwan, Abdelkhalik Eladl
Mansoura Engineering Journal
This study evaluates the technical feasibility of composting shredded printed paper blended with organic waste using a manually operated aerobic composting system. The investigation focused on process performance under controlled initial conditions, particularly an optimized carbon-to-nitrogen (C:N) ratio of 30:1. Three composting piles were constructed with systematic variations in moisture content, aeration frequency, and additive composition (poultry manure, yeast, crushed eggshells, and cardboard) to assess their influence on thermal behavior and decomposition efficiency. Process performance was monitored through continuous temperature profiling and periodic observation of physical parameters, including color development and material degradation rate. Among the experimental setups, Pile 3 …
Understanding The Effects Of Simulated Microgravity On Staphylococcus Epidermidis And Escherichia Coli In Co-Culture, Emma Costa, Mitchell K. Villafania, Makaila Olson, Kareigh N. Gammon, Hugo Castillo
Understanding The Effects Of Simulated Microgravity On Staphylococcus Epidermidis And Escherichia Coli In Co-Culture, Emma Costa, Mitchell K. Villafania, Makaila Olson, Kareigh N. Gammon, Hugo Castillo
Beyond: Undergraduate Research Journal
With the popularity of space travel increasing, it is important to understand the effects of microgravity on microbial communities as alterations on bacterial interactions can occur. Staphylococcus epidermidis and Escherichia coli are bacteria that are commonly found within human microbiomes. S. epidermidis is a cocci-shaped gram-positive bacterium that is part of the human skin microbiome. However, it can gather on sites of open skin and enter the body leading to an infection. E. coli is a rod-shaped gram-negative bacterium that can be found in the human gut microbiome. The pathogenic strains of E. coli have the potential to cause harmful …
Signal And Substance: Why Methodological Sophistication Fails To Guarantee Inference, Aamir Rashid, Rizwana Rasheed
Signal And Substance: Why Methodological Sophistication Fails To Guarantee Inference, Aamir Rashid, Rizwana Rasheed
Publications and Research
Despite increasing analytical sophistication, empirical research in organization studies continues to suffer from fragile inference, uneven theoretical accumulation, and contested credibility. This paper seeks to explain why these problems persist by shifting attention from authors’ methodological choices to the evaluative dynamics of peer review. Adopting a conceptual and theory-analytic approach, the paper theorizes peer review as an inferential gatekeeping system. Drawing on research design, theory evaluation, and philosophy-of-science literatures, this study develops an analytical framework to examine how evaluative routines shape what constitutes empirical rigor during the review process. The analysis identifies five recurring reviewer blind spots: inferential scope inflation, …
Nutritive Values Of Three Edible Green Seaweeds Collected From Dar Es Salaam Coast, Tanzania, Amelia S. Buriyo, Denis Gahunde, Kristian M. Kitali, David C. Simiyu
Nutritive Values Of Three Edible Green Seaweeds Collected From Dar Es Salaam Coast, Tanzania, Amelia S. Buriyo, Denis Gahunde, Kristian M. Kitali, David C. Simiyu
Tanzania Journal of Science
Tanzania is endowed with different seaweed (macroalgae) species, found abundantly along the coastline. Most of these hold a great potential as nutritious food sources with promising applications in food industry. These seaweeds could be highly utilized for effective management of the high levels of malnutrition in the country. Nonetheless, the nutritional potential of most seaweeds occurring in Tanzania is still unknown. Understanding the nutritional value of the commonly available edible seaweeds, could be an important step towards promoting them as food supplements in the country. In this study, the nutritive values (crude proteins, total carbohydrates, lipids, crude fibre, vitamins, and …
Effectiveness Of Organic Amendments In Enriching Nitrogen In Compost Produced From Organic Fractions Of Market Waste Generated In Dar Es Salaam, Tanzania, Amani Bilula, Ally Mahadhy, Anthony Manoni Mshandete, Amelia Kivaisi
Effectiveness Of Organic Amendments In Enriching Nitrogen In Compost Produced From Organic Fractions Of Market Waste Generated In Dar Es Salaam, Tanzania, Amani Bilula, Ally Mahadhy, Anthony Manoni Mshandete, Amelia Kivaisi
Tanzania Journal of Science
Low nitrogen (N) content remains a key limitation of compost derived from urban organic waste. This study evaluated the effectiveness of selected plant-based organic amendments in enhancing nitrogen content and improving compost quality. Four plant- based organic amendments, Leucaena leucocephala (BN01), Commelina benghalensis (BN02), Morus alba (BN03), and Helianthus annuus (sunflower) cake (BN04), were incorporated into market waste compost at ratios of 1:0.06:0.04, 1:0.06:0.25, and 1:0.06:0.5 (organic waste: sawdust: amendment). Composting was conducted using a 4 × 3 factorial design with three replicates per treatment (n = 36). Temperature, moisture, and pH were monitored throughout the composting period. Total nitrogen, …
Decoding The Allosteric Grammar Of Protein Kinases: A Dual-Stream Framework Integrating Protein Language Models And Energy Landscape Frustration Analysis, Will Gatlin, Max Ludwick, Lucas Turano, Brandon Foley, Kamila Riedlova, Vít Škrhák, Marian Novotný, David Hoksza, Gennady M. Verkhivker
Decoding The Allosteric Grammar Of Protein Kinases: A Dual-Stream Framework Integrating Protein Language Models And Energy Landscape Frustration Analysis, Will Gatlin, Max Ludwick, Lucas Turano, Brandon Foley, Kamila Riedlova, Vít Škrhák, Marian Novotný, David Hoksza, Gennady M. Verkhivker
Mathematics, Physics, and Computer Science Faculty Articles and Research
The spatial and energetic encoding of allosteric regulatory sites remains a major challenge in structural biology, frequently representing a “blind spot” for sequence-based artificial intelligence (AI) models. We present a protein language model (PLM)-guided approach complemented by the energy landscape frustration analysis as a dual-stream framework to investigate the relationship between AI prediction of binding sites and biophysical organization of regulatory pockets across the human kinome. By probing a fine-tuned residue-level PLM classifier across 453 kinase structures, a clear performance gap is discovered between highly predictable orthosteric pockets (Types I, I.5, and II) and poorly resolved distal allosteric sites (Type …
Upar-Guided Dendrimer Gel Nanoparticles Reprogram Inflammation To Stabilize Atherosclerotic Plaques, Hsin Yin Chuang, Huari Kou, Yue-Wern Huang, Hu Yang
Upar-Guided Dendrimer Gel Nanoparticles Reprogram Inflammation To Stabilize Atherosclerotic Plaques, Hsin Yin Chuang, Huari Kou, Yue-Wern Huang, Hu Yang
Biological Sciences Faculty Research & Creative Works
Atherosclerosis is characterized by lipid deposition, chronic inflammation, and apoptosis within the arterial wall, leading to plaque progression and instability. Current lipid-lowering therapies fail to fully address residual cardiovascular risk driven by local inflammation and cell death. Here, we report the development of uPA-functionalized, rapamycin-encapsulated dendrimer nanoparticles (G5PM-uPA/RA) that preferentially accumulate in urokinase plasminogen activator receptor (uPAR)-enriched atherosclerotic plaque, including macrophage- and apoptosis-rich lesion microenvironments. G5PM-uPA/RA was constructed by cross-linking reaction-enabled flash nanoprecipitation in a custom-made multi-inlet vortex mixer, followed by thiol-maleimide conjugation of uPA for uPAR-guided targeting. The nanoparticles demonstrated uniform morphology, favorable stability, and efficient rapamycin loading. In …
Spatiotemporal Trends In Schistocephalus Solidus Infection Among Populations Of Alaskan Threespine Stickleback (Gasterosteus Aculeatus), A.M Wohlleben, Neva Meyer, N.C. Steinel
Spatiotemporal Trends In Schistocephalus Solidus Infection Among Populations Of Alaskan Threespine Stickleback (Gasterosteus Aculeatus), A.M Wohlleben, Neva Meyer, N.C. Steinel
Biology
Understanding the dynamics of host-parasite interactions is essential for uncovering the ecological and evolutionary processes shaping natural populations. In this study, we investigated the spatial and temporal patterns of prevalence of the cestode Schistocephalus solidus in 4 Alaskan populations of threespine stickleback (Gasterosteus aculeatus) over 11 years (1996 to 2006). Additionally, we assessed host tolerance through key indicators such as the Parasite Index and the presence of fibrotic scar tissue, a specialized form of resistance in this system. We observed fibrosis formation in both infected and uninfected fish across all populations, with notable year-to-year variability in Cornelius Lake. Here, fibrosis …
Defining Life: A Conversation, K. Kofman, C. Adami, F. Baluška, J. Bongard, D. Brash, P. Calvo, G. Dodig-Crnkovic, P. Das, C. Fields, T. Froese, P. L. Gentili, G. Y. Georgiev, Scott F. Gilbert, T. N. W. Jackson, S. Kauffman, N. Lane, P. Marshall, D. Mcshea, W. Miller, S. Newman, A. Nunn, T. P. Pavlic, M. Picard, W. Ratcliff, A. Reber, J. Shapiro, A. Sloman, R. Solé, C. Sonnenschein, S. Stepney, R. Watson, O. Witkowski, M. Levin
Defining Life: A Conversation, K. Kofman, C. Adami, F. Baluška, J. Bongard, D. Brash, P. Calvo, G. Dodig-Crnkovic, P. Das, C. Fields, T. Froese, P. L. Gentili, G. Y. Georgiev, Scott F. Gilbert, T. N. W. Jackson, S. Kauffman, N. Lane, P. Marshall, D. Mcshea, W. Miller, S. Newman, A. Nunn, T. P. Pavlic, M. Picard, W. Ratcliff, A. Reber, J. Shapiro, A. Sloman, R. Solé, C. Sonnenschein, S. Stepney, R. Watson, O. Witkowski, M. Levin
Biology Faculty Works
Life is one of the most fascinating features of the physical world. Despite centuries of scientific study, experts still disagree about the definition, and even the possibility or utility of a definition, of this field. In a recent paper, we used AI to analyze the conceptual space formed by definitions of life given by a select set of modern workers in the life sciences and related fields. However, some of the most interesting material emerged as real-time conversations among those polled. In order to ensure that these ideas are not lost to the peer-reviewed scientific record, we here provide a …
Online Decoding Of Rat Self-Paced Locomotion Speed From Eeg Using Recurrent Neural Networks, Alejandro De Miguel, Nelson Totah, Uri Maoz
Online Decoding Of Rat Self-Paced Locomotion Speed From Eeg Using Recurrent Neural Networks, Alejandro De Miguel, Nelson Totah, Uri Maoz
Psychology Faculty Articles and Research
Objective. Accurate and reliable neural decoding of locomotion holds promise for advancing clinical applications such as rehabilitation and prosthetic control, as well as for understanding neural correlates of action. Recent studies have demonstrated successful decoding of locomotion kinematics across species in motorized treadmill settings. However, efforts to decode locomotion speed directly and continuously in more natural contexts—where pace is self-selected rather than externally imposed—are scarce, and those that exist generally achieve only modest accuracy and require intracranial implants. Here, we aim to decode self-paced locomotion speed non-invasively and continuously using cortex-wide electroencephalography (EEG) recordings from rats. Approach. We introduce an …