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Towards Sustainable Marine Education: Assessing High School Students’ Understanding Of Conservation Concepts, Cheng-Chieh Chang, Tsuyoshi Sasaki, Ya-Yin Liao, Ling-Ya Hung, Liang-Ting Tsai Jun 2026

Towards Sustainable Marine Education: Assessing High School Students’ Understanding Of Conservation Concepts, Cheng-Chieh Chang, Tsuyoshi Sasaki, Ya-Yin Liao, Ling-Ya Hung, Liang-Ting Tsai

Journal of Marine Science and Technology–Taiwan

This study assesses the concepts of marine resource conservation and sustainability among Taiwanese high school students by developing a Chinese version of the Marine Resources Conservation and Sustainability Scale. Grounded in the cognitive, socio-emotional, and behavioral learning objectives outlined in UNESCO’s Education for Sustainable Development Goals (ESDGs), the scale targets students aged 16 to 18 to examine gender differences in marine knowledge and conservation concepts. The scale comprises 31 items across four dimensions: the first section evaluates marine knowledge, while the remaining dimensions utilize a four-point Likert scale to assess cognitive, socio-emotional, and behavioral learning objectives, respectively. The results indicate …


Dynamic Governance Of Transboundary Fisheries Through Deep Learning And High-Frequency Vessel Tracking Data For Climate-Resilient Management: An Application To The East China Sea, Qin Lin, Yaqing Shu, Manel Grifoll, Hongxiang Feng Jun 2026

Dynamic Governance Of Transboundary Fisheries Through Deep Learning And High-Frequency Vessel Tracking Data For Climate-Resilient Management: An Application To The East China Sea, Qin Lin, Yaqing Shu, Manel Grifoll, Hongxiang Feng

Journal of Marine Science and Technology–Taiwan

Transboundary fisheries governance is increasingly challenged by jurisdictional conflicts, regulatory asymmetries, and climate-induced stock shifts in fish stocks, especially in contested regions like the East China Sea (ECS). This study capitalizes on China’s high-frequency BeiDou Navigation Satellite System (BDS) data (June 2021–May 2022) to pioneer a CNN-BiLSTM deep learning model to dynamically identify fishing hotspots and evaluate policy effectiveness. By integrating vessel trajectories, environmental variables, and regulatory events, we examine spatiotemporal patterns of fishing effort relative to seasonal bans, extreme weather, and quota systems. Key findings reveal: (1) post-moratorium (September–December) concentration of fishing intensity, peaking in November; (2) significant weather-driven …


Lock Scheduling Decisions And Strategy Optimization Under Operation Interruption Scenarios, Junhe Li, Qiang Zhang, Junpeng Jiang, Jiangchao Bao Jun 2026

Lock Scheduling Decisions And Strategy Optimization Under Operation Interruption Scenarios, Junhe Li, Qiang Zhang, Junpeng Jiang, Jiangchao Bao

Journal of Marine Science and Technology–Taiwan

Locks are critical nodes in inland waterway transportation systems that concentrate vessel traffic between upstream and downstream reaches, making their operations highly sensitive to hydrological conditions. Therefore, disruptions caused by droughts, floods, or routine maintenance can easily trigger congestion. To address this issue, this study systematically examines the interrelationships among the number of ships awaiting passage, scheduling strategies, the trade-off between lock chamber utilization and ship waiting time, the influence of ship entry sequences on user satisfaction, and the combined effects of these factors on overall lock scheduling performance. Based on these analyses, an integrated decision-making model for two-stage ship …


Corrosion Protection Assessment Of Offshore Wind Turbine Substructures Using Beasy Cp Simulation Analysis, Chuan-Yang Wan, Hung-Hua Sheu, Sheng-Yu Wang, Yao-Ming Wang, Wei-De Chen, Ming-Yuan Lin, Hung-Bin Lee Jun 2026

Corrosion Protection Assessment Of Offshore Wind Turbine Substructures Using Beasy Cp Simulation Analysis, Chuan-Yang Wan, Hung-Hua Sheu, Sheng-Yu Wang, Yao-Ming Wang, Wei-De Chen, Ming-Yuan Lin, Hung-Bin Lee

Journal of Marine Science and Technology–Taiwan

This study investigates the corrosion protection assessment of offshore wind turbine substructures established in the waters off Keelung, Taiwan. First, a cathodic protection system for the monopile foundation is designed and established. The Boundary Element Method (BEM) is applied using the BEASY simulation software to develop a 3D geometric model for cathodic protection. In the steel monopile simulation analysis, the exposed marine environment is set based on the sea conditions of the Keelung small boat marina, including parameters such as salinity, resistance, and polarization curves, to establish an effective cathodic protection system for underwater structures. By simulating these parameters, a …


Face-To-Face Versus Distance Education In Competence-Based Maritime Education And Training, Clara Borén, Marcella Castells-Sanabra, Manel Grifoll Jun 2026

Face-To-Face Versus Distance Education In Competence-Based Maritime Education And Training, Clara Borén, Marcella Castells-Sanabra, Manel Grifoll

Journal of Marine Science and Technology–Taiwan

The COVID-19 pandemic created significant challenges for higher education, with universities being shut down and face-to-face teaching and assessment shifting to an online format. This presented an opportunity to focus on the continuity of learning through distance education, especially in the maritime context, due to the on-board training requirements, and even though five years have passed, this shift has reshaped the education landscape, proving that remote learning has come to stay.

At the Barcelona School of Nautical Studies, we have developed a weather routing software in the framework of distance education and teaching innovation. We conducted a teaching trial alternatively …


Elucidating The Function Of Yedk In Response To Dna Damage, Hank Munro Jun 2026

Elucidating The Function Of Yedk In Response To Dna Damage, Hank Munro

University Honors Theses

Apurinic/Apyrimidinic (AP) sites are one of the most prevalent forms of DNA damage. These lesions arise spontaneously or during base excision repair of modified DNA bases and are potentially mutagenic in both mammalian and bacterial cells. 5-hydroxymethylcytosine binding, ES cell specific (HMCES), a protein found in eukaryotic cells, has been shown to form a stable DNA-protein crosslink with AP sites in single stranded DNA and to reduce the number of AP sites occurring either spontaneously or after alkylative DNA damage, resulting in increased genome stability. YedK, the Escherichia coli ortholog of HMCES exhibits some of the same biochemical properties as …


Why Student Research Matters: A Graduate Student’S Perspective, Jessica L. Hensley Jun 2026

Why Student Research Matters: A Graduate Student’S Perspective, Jessica L. Hensley

The Journal of Integrative Physiology

Research fundamentally changes how students engage with knowledge. Rather than memorizing established facts, students learn to question, analyze, and contribute to the body of knowledge within their field (1). This shift supports deeper understanding and promotes critical thinking skills by encouraging active construction of knowledge (1). It also exposes students to the process of engaging with scientific literature and integrating information within the context of their research (2).

In my experience, research requires individuals to confront uncertainty. Experiments do not always produce exact results, and methods can require modification. Through this process, students develop adaptability, persistence, and the ability to …


Evaluating The Impact Of Early Contractor Involvement On Enhancing The Performance Of Construction Projects In Egypt, Samah Saleh Abdelraof, Ayman Ahmed Ezzat Othman, Lamees Mostafa Ahmed Jun 2026

Evaluating The Impact Of Early Contractor Involvement On Enhancing The Performance Of Construction Projects In Egypt, Samah Saleh Abdelraof, Ayman Ahmed Ezzat Othman, Lamees Mostafa Ahmed

Mansoura Engineering Journal

The construction industry constitutes a critical pillar of Egypt’s national economic growth and sustainable development. Despite its strategic importance, the sector continues to face persistent challenges, including chronic cost overruns, schedule delays, and inadequate coordination among stakeholders. These inefficiencies are largely attributed to the dominance of the traditional Design–Bid–Build (DBB) system, which enforces a rigid separation between design and construction, fostering adversarial relationships and project disputes, which highlights the need for alternative procurement approaches. This research investigates the impact of Early Contractor Involvement (ECI) as a collaborative procurement alternative to enhance project performance. Case studies show that ECI improves early-stage …


The Neuroprotective Effect Of Cdc42 Inhibition In The G93a Mutant Hsod1 Mouse Model Of Als, Andrea Koly Jun 2026

The Neuroprotective Effect Of Cdc42 Inhibition In The G93a Mutant Hsod1 Mouse Model Of Als, Andrea Koly

Undergraduate Theses, Capstones, and Recitals

Amyotrophic lateral sclerosis (ALS) is a progressive and fatal neurodegenerative disease characterized by the selective loss of upper and lower motor neurons, leading to muscle weakness, neuromuscular junction (NMJ) degeneration, paralysis, and eventual death due to respiratory failure. Despite extensive research, effective disease-modifying therapies remain limited, underscoring the need to identify novel molecular targets involved in ALS pathogenesis. Dysregulation of Rho family GTPases has been implicated in neurodegeneration, with Rac and Rho exerting opposing effects on neuronal survival; however, the role of the closely related GTPase Cdc42 remains poorly understood in ALS. In this study, the therapeutic potential of inhibiting …


Differential Roles Of Moesin And Vasp In Β-Catenin-Associated Networks During Zebrafish Heart Regeneration, Allen Rutman Jun 2026

Differential Roles Of Moesin And Vasp In Β-Catenin-Associated Networks During Zebrafish Heart Regeneration, Allen Rutman

Undergraduate Theses, Capstones, and Recitals

With cardiovascular disease remaining as the leading cause of mortality worldwide, it is largely due to the limited regenerative capacity of the human heart. However, zebrafish (Danio rerio) can fully regenerate cardiac tissue following injury, providing a valuable model for studying the mechanisms of heart repair. To investigate these mechanisms, we used proteomics methods in the past. Proximity labeling is a technique that identifies proteins based on their physical proximity to a protein of interest. It can be applied in organisms and in living cells (Roux et al., 2012; Cho et al., 2020). We used proximity labeling to characterize protein …


Exploring The Relationship Between Tree Dbh And Lichen Cover On Coast Redwood, Grace M. Personeus, Sierra Gittleman, Alisa A. Zarattini Jun 2026

Exploring The Relationship Between Tree Dbh And Lichen Cover On Coast Redwood, Grace M. Personeus, Sierra Gittleman, Alisa A. Zarattini

IdeaFest: Interdisciplinary Journal of Creative Works and Research from Cal Poly Humboldt

We investigated the relationship between Diameter at Breast Height (DBH) and lichen cover on coast redwood (Sequoia sempervirens) to see if larger trees had higher percentages of cover. We measured cover using 10 cover classes on the southeastern and southwestern sides of trees in a secondary growth forest. We found a significant relationship between DBH and cover, yet no significant difference between the two sides measured. We suggest that further research with a larger sample size and more varied age classes will provide further insight into the relationship.


Allosteric And Uncompetitive Inhibition Of Yeast Alcohol Dehydrogenase Identified By Enzyme Kinetics, Dylan Jeremy Harrison, Jenny A. Cappuccio Jun 2026

Allosteric And Uncompetitive Inhibition Of Yeast Alcohol Dehydrogenase Identified By Enzyme Kinetics, Dylan Jeremy Harrison, Jenny A. Cappuccio

IdeaFest: Interdisciplinary Journal of Creative Works and Research from Cal Poly Humboldt

Enzyme kinetics is a powerful technique used to quantify the rate at which an enzyme converts a substrate into a product and to identify potential inhibitors. In this study, kinetic analysis was employed to assess the activity of yeast alcohol dehydrogenase (YADH) in the presence and absence of sweeteners commonly found in alcoholic beverages. YADH catalyzes the oxidation of ethanol to acetaldehyde using NAD⁺ as a cofactor; the reduction to NADH can be monitored spectrophotometrically at 340 nm. Based on structural similarities to the ribose moiety of NAD⁺, it was hypothesized that sucrose and sucralose could directly interact with the …


Neuromuscular Responses During Vigorous Intensity Heart Rate-Clamp Cycling Exercise, Clara J. Mitchinson, Pasquale J. Succi, Brian Benitez, Djadmann Gustave, Minyoung Kwak, Erik Snell, Haley C. Bergstrom Jun 2026

Neuromuscular Responses During Vigorous Intensity Heart Rate-Clamp Cycling Exercise, Clara J. Mitchinson, Pasquale J. Succi, Brian Benitez, Djadmann Gustave, Minyoung Kwak, Erik Snell, Haley C. Bergstrom

Journal for Sports Neuroscience

Introduction: Electromyography (EMG) and mechanomyography (MMG) provide non-invasive assessments of neuromuscular function and fatigue during dynamic exercise. This study examined neuromuscular fatigue and cycling performance through changes in power output (PO), total work (TW), EMG and MMG, amplitude (AMP) and mean power frequency (MPF) during three, heart rate (HR)-Clamp trials in the vigorous range (77-95% HRmax). Methods: Ten men (mean±SD, 25.9±5.0yr, 74.9±15.0kg, HRmax=178±12b×min-1) performed a cycle ergometer graded exercise test, followed by three separate HR-Clamp trials at 77%HRmax (HRL, time to exhaustion [TLim]=58.5±4.6 min, range=45.3-60.0min), 86%HRmax (HRM …


A Computational Micropatterning Approach To Study Caveolae And Protein Localization In Vascular Biology, Andrew B. Grespin Jun 2026

A Computational Micropatterning Approach To Study Caveolae And Protein Localization In Vascular Biology, Andrew B. Grespin

Electronic Theses and Dissertations

Caveolae are specialized, flask-shaped membrane invaginations highly expressed in endothelium and dysregulated in atherosclerosis. Caveolae play a central role in buffering membrane tension, yet the principles governing their spatial organization remain elusive. Thus, we sought to generate the most comprehensive and systematic analysis of blood vessel caveolar spatial organization. However, cell culturing, the backbone of human-focused biological research, does not standardly do well to model physiologically relevant cell behaviors such as migration or polarity-based tissue formation, particularly for punctate proteins and structures like caveolae. Micropatterns are cell-adhesive shapes that biophysically confine cell(s) to a user defined geometry which stereotype organelle …


The Palm Farm Next-Door: Land Concessions, Livelihoods, And Nutrition In Plantation-Adjacent Communities, Julia Entwistle Jun 2026

The Palm Farm Next-Door: Land Concessions, Livelihoods, And Nutrition In Plantation-Adjacent Communities, Julia Entwistle

Electronic Theses and Dissertations

Large-scale land concessions have reshaped agrarian landscapes globally, yet their implications for community land tenure, livelihoods, and nutrition remain unevenly understood. This dissertation examines how plantation agriculture and foreign investment have transformed land access, labor relations, and food systems in Liberia, a country with one of the highest proportions of land under concession globally. Guided by a political ecology framework, the study employs a mixed-methods design integrating policy analysis, in-depth interviews, and household surveys across two palm oil concession sites. The findings show that ambiguous land policies historically facilitated dispossession, while recent legal reforms have enabled communities to strategically mobilize …


Diet And Microbiome Shape Small-Molecule Cytokinin Pools In Mammals, Eman M. Othman, Elena Bencurova, Pamela Ferretti, Peer Bork, Alvaro Rodriguez Del Rio, Jaime Huerta-Cepas, Ignazio Caruana, Rania Abdel-Latif, Aman Akash, Alfonso Albacete, Feras Lafi, Thomas Dandekar, Muhammad Naseem Jun 2026

Diet And Microbiome Shape Small-Molecule Cytokinin Pools In Mammals, Eman M. Othman, Elena Bencurova, Pamela Ferretti, Peer Bork, Alvaro Rodriguez Del Rio, Jaime Huerta-Cepas, Ignazio Caruana, Rania Abdel-Latif, Aman Akash, Alfonso Albacete, Feras Lafi, Thomas Dandekar, Muhammad Naseem

All Works

Cytokinins (CKs) are adenine-derived metabolites traditionally characterized as plant hormones, yet their origin, distribution, and functions in mammalian systems remain largely undefined. Using integrated metabolomics, microbiome, and metagenomics approaches, we provide a systematic characterization of CK occurrence and potential sources in mammals. Serum profiling across five animal species revealed consistent detection of multiple CK derivatives, with concentrations markedly lower than in plant tissue. The CK storage form, zeatin-O-glucoside, predominated in mammalian sera, followed by trans-zeatin and kinetin, indicating a CK composition distinct from that in plants. Species-specific differences, such as reduced trans-zeatin in mice and lower kinetin in humans, further …


Origins Of Mitochondrial Diversity In Turkish Sheep Breeds: Anatolia As A Contact Zone Or Refugial Center?, Nezi̇h Ata, İbrahi̇m Cemal Jun 2026

Origins Of Mitochondrial Diversity In Turkish Sheep Breeds: Anatolia As A Contact Zone Or Refugial Center?, Nezi̇h Ata, İbrahi̇m Cemal

Turkish Journal of Veterinary & Animal Sciences

Advances in molecular genetics, especially the integration of mitochondrial DNA (mtDNA) analyses, have significantly transformed our understanding of the origins, geographical centers, and dispersal dynamics of domestication, a field traditionally based on archaeological and morphological evidence. In this study, the mtDNA control-region sequences of 296 individuals from 15 native Turkish sheep breeds were analyzed to clarify their maternal genetic diversity and evolutionary origins. Sequencing of a 531-bp D-loop fragment revealed 53 polymorphic sites and 78 distinct haplotypes, indicating substantial haplotypic diversity (Hd = 0.918) and nucleotide diversity (π = 0.01391) within these populations. All five major ovine mitochondrial haplogroups (A, …


The In Vitro Feeding Of Hyalomma Marginatum (Koch, 1844), Nesli̇han Ölmez, Bariş Sari, Zati̇ Vatansever Jun 2026

The In Vitro Feeding Of Hyalomma Marginatum (Koch, 1844), Nesli̇han Ölmez, Bariş Sari, Zati̇ Vatansever

Turkish Journal of Veterinary & Animal Sciences

Ticks are obligate hematophagous ectoparasites that play a major role in the transmission of pathogens affecting both animals and humans. Investigations into tick biology, pathogen transmission, and the development of effective control strategies have traditionally depended on the extensive use of laboratory animals. Consequently, the development of reliable in vitro feeding systems is a valuable alternative approach with the potential to reduce animal use in tick research. In the present study, a previously described silicone membrane artificial feeding system was modified and applied for the in vitro feeding of Hyalomma marginatum (Koch, 1844). Feeding units were prepared using bovine blood …


Comparison Of Bacteriological Culture And A Multiplex Real-Time Pcr Kit For The Detection Of Mastitis Pathogens In Small Ruminants, Ebru Karakaya Bi̇len, Serpi̇l Kahya Demi̇rbi̇lek, Bariş Güner, Öznur Yilmaz Koç, Ali̇ Ünver, Merve Yildiz, İrem Çakmak, Abdulkadi̇r Keski̇n Jun 2026

Comparison Of Bacteriological Culture And A Multiplex Real-Time Pcr Kit For The Detection Of Mastitis Pathogens In Small Ruminants, Ebru Karakaya Bi̇len, Serpi̇l Kahya Demi̇rbi̇lek, Bariş Güner, Öznur Yilmaz Koç, Ali̇ Ünver, Merve Yildiz, İrem Çakmak, Abdulkadi̇r Keski̇n

Turkish Journal of Veterinary & Animal Sciences

This study aimed to evaluate the applicability of a multiplex real-time PCR (rPCR) kit, originally developed for bovine mastitis, for detecting mastitis pathogens in small ruminants and reducing bacterial identification time compared with conventional bacteriological culture (BC). Milk samples were obtained from 175 sheep and 124 goats and included cases of clinical mastitis (n = 57) and subclinical mastitis (n = 242). With BC, bacterial growth was detected in 125 of 299 milk samples (41.8%), yielding a total of 169 bacterial isolates. The pathogens most frequently isolated by BC were coagulase-negative staphylococci (58.0%), followed by Streptococcus spp. (9.4%), Staphylococcus aureus …


Comparative Efficacy Of Controlled Internal Drug Release And Medroxyprogesterone Acetate Sponges On Ovulatory Follicle Growth In The Ovsynch Protocol During The Breeding Season In Cyclic Nili Ravi Buffaloes, Muhammad Binyameen, Ali Husnain, Saba Anwar, Muhammad Waseem, Muhammad Saleem Jun 2026

Comparative Efficacy Of Controlled Internal Drug Release And Medroxyprogesterone Acetate Sponges On Ovulatory Follicle Growth In The Ovsynch Protocol During The Breeding Season In Cyclic Nili Ravi Buffaloes, Muhammad Binyameen, Ali Husnain, Saba Anwar, Muhammad Waseem, Muhammad Saleem

Turkish Journal of Veterinary & Animal Sciences

The objective of the experiment was to compare the dominant follicle size, growth rate of the dominant follicle, estrus response, plasma progesterone concentration, and pregnancy in Nili Ravi buffaloes synchronized by controlled internal drug release (CIDR; 1.38 g) and medroxyprogesterone acetate sponge (MPAS; 250 mg) in the ovulation synchronization (OvSynch) protocol. The experiment had a randomized complete block design. Buffaloes (n = 42) were blocked by parity, body weight, body condition score, and ovarian status, and, within the block, they were randomized to receive either CIDR or MPAS and that day was considered day 0 of the experiment. On days …


Determination Of Hematobiochemical Parameters And Egg Quality Traits Of Turkish Sultan Chickens, Mehmet Naci̇ Oktay, Ruhi̇ Kabakçi, Ali̇ Karapinar, Gökhan Şen, Taha Altuğ, Yasi̇n Şenel Jun 2026

Determination Of Hematobiochemical Parameters And Egg Quality Traits Of Turkish Sultan Chickens, Mehmet Naci̇ Oktay, Ruhi̇ Kabakçi, Ali̇ Karapinar, Gökhan Şen, Taha Altuğ, Yasi̇n Şenel

Turkish Journal of Veterinary & Animal Sciences

The present study aimed to investigate the hematological and biochemical blood parameters, along with selected egg quality traits, of Turkish Sultan chickens. A total of 90 blood samples collected from 60-week-old hens and roosters and 129 eggs collected from 50 hens were analyzed. The findings showed that hematological parameters such as red blood cells (RBC), hemoglobin (HGB), packed cell volume (PCV), mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), and heterophil-to-lymphocyte (H/L) ratio, as well as biochemical markers such as aspartate aminotransferase (AST), lactate dehydrogenase (LDH), and uric acid levels, were significantly higher in roosters. The average egg weight, shape …


Immunohistochemical Expression Of Lgr5 In The Bovine Ovary, Oviduct, And Uterus, Aytül Kürüm, Yasi̇n Özkabadayi, Hakan Kocamiş, Mustafa Türk, Si̇yami̇ Karahan Jun 2026

Immunohistochemical Expression Of Lgr5 In The Bovine Ovary, Oviduct, And Uterus, Aytül Kürüm, Yasi̇n Özkabadayi, Hakan Kocamiş, Mustafa Türk, Si̇yami̇ Karahan

Turkish Journal of Veterinary & Animal Sciences

Leucine-rich repeat-containing G-protein coupled receptor 5 (LGR5) has recently been considered as a stem cell marker seen especially in mitotically active tissues. The aim of the present study was to investigate the immunohistochemical expression of LGR5 in the bovine reproductive tract, which is regularly renewed in response to hormonal changes throughout the estrous cycle. The oviduct (ampulla, isthmus, and fimbria), uterus, and ovary tissue samples were collected from 12 cows at a local slaughterhouse. The samples were further identified as follicular (n = 6) or luteal (n = 6), subjected to routine histological procedures, and processed for immunohistochemical expression of …


Colostrum And Rethinking Passive Transfer In Dairy Calves, Drew Swartz, Kalen Taylor, Maggi Mathews Jun 2026

Colostrum And Rethinking Passive Transfer In Dairy Calves, Drew Swartz, Kalen Taylor, Maggi Mathews

All Current Publications

This fact sheet provides an overview of colostrum and passive transfer in dairy calves, with information applicable to producers, consultants, educators, and students.


Colostrum Management For Dairy Calves: Technical Guidelines For Consultant Evaluation And Implementation, Drew Swartz, Jacob Hadfield, Kalen Taylor, Maggi Mathews Jun 2026

Colostrum Management For Dairy Calves: Technical Guidelines For Consultant Evaluation And Implementation, Drew Swartz, Jacob Hadfield, Kalen Taylor, Maggi Mathews

All Current Publications

This fact sheet provides a technical overview of colostrum management in dairy calves, including evaluation methods and evidence-based recommendations for consultants, educators, and students.


Defining Replication-Driven Vulnerabilities In High Grade Serous Ovarian Cancers, Natasha Maya Ramakrishnan Jun 2026

Defining Replication-Driven Vulnerabilities In High Grade Serous Ovarian Cancers, Natasha Maya Ramakrishnan

Arts & Sciences Graduate Student Theses and Dissertations

High grade serous ovarian carcinoma (HGSOC) is an aggressive, highly lethal subtype of ovarian cancer. These cancers are typically diagnosed in later stages and are associated with poor patient prognosis. Additionally, HGSOC is characterized by numerous markers of genomic instability and defects in DNA repair pathways, vulnerabilities which have been exploited by the advancement of chemotherapy. Despite these clinical advancements, HGSOC remains a significant therapeutic challenge due to emergence of chemoresistance and limited targeted treatment options. Taken together, these factors highlight an ongoing need to study the development of HGSOC and its progression to identify more effective treatment opportunities. We …


The Gut Microbiome, The Gut-Brain Axis, And College Student Well-Being, Idi Mckay Jun 2026

The Gut Microbiome, The Gut-Brain Axis, And College Student Well-Being, Idi Mckay

University Honors Theses

This literature review examines how diet, stress, environmental exposure, and food accessibility may influence college students' mental health and academic performance through the gut microbiome and the Gut-Brain Axis (GBA). Current microbiome research often focuses on early childhood development, clinical disease populations, or older adults, while overlooking college-age students who experience significant social, environmental, and biological transitions. College students frequently face food insecurity, irregular eating patterns, chronic stress, inconsistent sleep schedules, and reduced access to nutrient-dense foods, all of which may influence microbial diversity and overall gut health.

This thesis explores how modern campus environments and lifestyle factors may contribute …


Effect Of Temperature On The Defensive And Predatory Behavior Of The Scorpion Hadrurus Obscurus (Scorpiones: Hadruridae), Zia Nisani, Megan Bennett, Audrey Enriquez, Mel Iniquez, Emilia Martinez Rios, Brooklyn Stone Jun 2026

Effect Of Temperature On The Defensive And Predatory Behavior Of The Scorpion Hadrurus Obscurus (Scorpiones: Hadruridae), Zia Nisani, Megan Bennett, Audrey Enriquez, Mel Iniquez, Emilia Martinez Rios, Brooklyn Stone

Euscorpius

Scorpions employ their stinging mechanism both for defense and predation, and being ectothermic, temperature influences their physiology and behavior. As such, we hypothesized that temperature both affects defensive stinging and prey-capture behavior in scorpions. We tested the effects of body temperature on these behaviors in the desert hairy scorpion, Hadrurus obscurus Williams, 1970. In the first experiment, scorpions were placed in temperature-controlled chambers with either high (26-28°C) or low (21- 22°C) temperatures and probed to elicit a defensive sting. We recorded the reaction time and the number of probes needed to elicit a sting. In the second experiment, we observed …


High Mobility Group Motif Proteins’ Role In Fibrosis, Inflammation, And Vascular Injury In Systemic Sclerosis, Fabian A. Mendoza, Sonsoles Piera-Velazquez, Sergio A. Jimenez Jun 2026

High Mobility Group Motif Proteins’ Role In Fibrosis, Inflammation, And Vascular Injury In Systemic Sclerosis, Fabian A. Mendoza, Sonsoles Piera-Velazquez, Sergio A. Jimenez

Jefferson Institute of Molecular Medicine Papers and Presentations

Systemic Sclerosis (SSc) is an idiopathic systemic autoimmune disease characterized by progressive cutaneous and systemic fibrosis, severe vasculopathy, and multiple humoral and cellular immunological alterations. The pathogenesis of SSc is highly complex and remains incompletely elucidated. The fibrotic process is a crucial component of SSc and is responsible for organ failure and high mortality. Although an increasing understanding of the fibrotic process has enabled the clinical development of antifibrotic therapeutic agents, these agents have limited clinical efficacy. Recently, the potential role of a group of transcription factors containing a High Mobility Group (HMG) motif, in the development and pathological manifestations …


Proteomic Evidence Indicates Ultrasound-Assisted Extraction Enhances Recovery Of Membrane-Associated Proteins In Hericium Erinaceus, Tanvir Ahmed, Angéla Juhász, Utpal Bose, Netsanet Shiferaw Terefe, Michelle L. Colgrave Jun 2026

Proteomic Evidence Indicates Ultrasound-Assisted Extraction Enhances Recovery Of Membrane-Associated Proteins In Hericium Erinaceus, Tanvir Ahmed, Angéla Juhász, Utpal Bose, Netsanet Shiferaw Terefe, Michelle L. Colgrave

Research outputs 2022 to 2026

Membrane-associated fungal proteins mediate essential functions and contain bioactive proteins with therapeutic potential but are underrepresented in aqueous extracts due to hydrophobicity and lipid associations. Ultrasound-assisted aqueous extraction was applied to Lion’s mane (Hericium erinaceus), and the proteins were fractionated by molecular weight (≥30 kDa, 10–30 kDa, 3–10 kDa). Proteomic profiling using data-dependent (DDA) and data-independent (DIA) mass spectrometry identified 1500 and 1702 proteins, respectively (1% global FDR). Ultrasonication induced surface irregularity and a less compact, heterogeneous microstructure. Topology predictions showed higher proportions of transmembrane and secretory proteins in ultrasonicated fractions. Extraction preserved protein integrity (82% molecular-weight retention, 97% tryptic …


Immune Suppression And Metabolic Reprogramming In Bactrocera Dorsalis Parasitized By Fopius Arisanus, Rehemah Gwokyalya, Jeremy Herren, Thomas Ogao Onchuru, Sahadatou Mama Sambo, Cassandra Purity Ronnie, Ndlela Shepard, Sunday Ekesi, Samira A. Mohamed Jun 2026

Immune Suppression And Metabolic Reprogramming In Bactrocera Dorsalis Parasitized By Fopius Arisanus, Rehemah Gwokyalya, Jeremy Herren, Thomas Ogao Onchuru, Sahadatou Mama Sambo, Cassandra Purity Ronnie, Ndlela Shepard, Sunday Ekesi, Samira A. Mohamed

All Peer-Reviewed Publications

Abstract – Bactrocera dorsalis is a major horticultural pest. Biocontrol using parasitoids, such as Fopius arisanus, is a sustainable tool for managing this pest. However, the mechanisms enabling the successful parasitism of B. dorsalis are poorly understood. Using transcriptomic profiling, cellular bioassays, and targeted metabolite analyses, we investigated how F. arisanus modulates the immunity and metabolic activity of B. dorsalis to achieve a high parasitism rate. Our results revealed a weak and late encapsulation response of B. dorsalis towards F. arisanus. Additionally, parasitism reduced the number of circulating haemocytes by 35%, lowered constitutive granulocyte counts and inhibited phenoloxidase activity in …