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Comparative Analysis Of Probiotic Viability In Alcoholic And Non-Alcoholic Kombucha, Isabella N. Cerrone, Brooke Pirkle, Danielle Williamson, Gianna Vendrell, Chloe Kraft Nov 2025

Comparative Analysis Of Probiotic Viability In Alcoholic And Non-Alcoholic Kombucha, Isabella N. Cerrone, Brooke Pirkle, Danielle Williamson, Gianna Vendrell, Chloe Kraft

Humboldt Journal of Microbiology

Kombucha is a fermented tea beverage valued for its probiotic and antimicrobial properties that arise from complex molecular interactions between yeast, acetic acid bacteria (AAB), lactic acid bacteria (LAB), and metabolic byproducts of fermentation. With the rising demand for non-alcoholic versions of traditionally alcoholic kombucha beverages, ethanol reduction methods have become common, though their impact on probiotic viability and antimicrobial properties remains poorly understood. This study investigates the effects of ethanol removal on kombucha’s functional properties, including probiotic survival, antimicrobial activity, and organic acid composition (pH). We compared alcoholic and non-alcoholic versions of JuneShine kombucha across five flavors. Probiotic viability …


Impact Of Physiological And Environmental Variation On The Behavioral Response Of The Two Biological Control Agents Of The Emerald Ash Borer To Host-Associated Odors, Vanshika Jindal Nov 2025

Impact Of Physiological And Environmental Variation On The Behavioral Response Of The Two Biological Control Agents Of The Emerald Ash Borer To Host-Associated Odors, Vanshika Jindal

LSU Master's Theses

Emerald ash borer (Agrilus planipennis Fairmaire; EAB) is an invasive pest that threatens ash trees (Fraxinus spp.) throughout North America and Europe. Since its introduction to North America, EAB has killed hundreds of millions of trees, resulting in severe ecological and economic damage exceeding 10 billion US dollars. Classical biological control involves the introduction of natural enemies from the native range of pests to manage their populations. Specialist parasitoid wasps have been released to reduce the populations of EAB. Detection and response to long-range attractants associated with EAB is critical for the location and parasitism by classical biological …


The Functional Efficiency Of Healing Gardens Elements And Its Impact On The Functional Aspect Of Hospitals, Menna Allah Hesham Mohammed, Heba Mohamed Abdou Nov 2025

The Functional Efficiency Of Healing Gardens Elements And Its Impact On The Functional Aspect Of Hospitals, Menna Allah Hesham Mohammed, Heba Mohamed Abdou

Mansoura Engineering Journal

Communication with nature has a positive effect on human health and well-being in different civilizations all time. But technological development caused the production of purely functional buildings that are far from communicating with nature, although some buildings contain gardens to achieve communication with nature, their elements are poor. Therefore, healing gardens are considered one of the main elements to raise the efficiency of the functional performance of the health building because they contain the resting places and healing departments. Therefore, this study focuses on determining the functional criteria for the elements of the garden that must be considered when designing …


Preclinical Fluorescence-Guided Imaging Leveraging Surrounding Sentinel Tumor Microenvironment Identifies High-Risk Premalignant Pancreatic Lesions, Shilpa Sharma, Xiaoxia Wen, Jianbo Wang, Beibei Huang, Denise A Hernandez, Zhiwen Liu, Aiko Yamaguchi, Dimitra K Georgiou, Ryan P Coll, H Charles Manning Nov 2025

Preclinical Fluorescence-Guided Imaging Leveraging Surrounding Sentinel Tumor Microenvironment Identifies High-Risk Premalignant Pancreatic Lesions, Shilpa Sharma, Xiaoxia Wen, Jianbo Wang, Beibei Huang, Denise A Hernandez, Zhiwen Liu, Aiko Yamaguchi, Dimitra K Georgiou, Ryan P Coll, H Charles Manning

Faculty, Staff and Student Publications

Purpose: Because surgery is the only potential cure for pancreatic cancer, high-risk premalignant pancreatic lesions often evade detection by palpation or white-light visualization, increasing the risk of recurrence. We asked whether near-infrared fluorescence imaging of tumor-associated inflammation could identify high-risk premalignant lesions, leveraging the tumor microenvironment as a sentinel of local disease and, thus, enhance surgery outcomes.

Experimental design: Fluorescence-guided surgery was performed on genetically engineered mice [Ptf1a-Cre; LSL-KrasG12D/+; Smad4flox/flox (KSC)] at discrete stages of disease progression, histologically confirmed high-risk, premalignant lesions in postnatal mice to locally advanced pancreatic tumors in adults, using the imaging agent V-1520, a translocator protein …


An Annotated Biobank Of Triple-Negative Breast Cancer Patient-Derived Xenografts Features Treatment-Naïve And Longitudinal Samples During Neoadjuvant Chemotherapy, Amanda L Rinkenbaugh, Yuan Qi, Shirong Cai, Jiansu Shao, Faiza Baameur Hancock, Xiaomei Zhang, Lei Huo, Rosanna Lau, Chunxiao Fu, Rebekah Gould, Petra Den Hollander, Elizabeth E Ravenberg, Jason B White, Gaiane M Rauch, Banu Arun, Clinton Yam, Alastair M Thompson, Gloria V Echeverria, Stacy L Moulder, W Fraser Symmans, Jeffrey T Chang, Helen Piwnica-Worms Nov 2025

An Annotated Biobank Of Triple-Negative Breast Cancer Patient-Derived Xenografts Features Treatment-Naïve And Longitudinal Samples During Neoadjuvant Chemotherapy, Amanda L Rinkenbaugh, Yuan Qi, Shirong Cai, Jiansu Shao, Faiza Baameur Hancock, Xiaomei Zhang, Lei Huo, Rosanna Lau, Chunxiao Fu, Rebekah Gould, Petra Den Hollander, Elizabeth E Ravenberg, Jason B White, Gaiane M Rauch, Banu Arun, Clinton Yam, Alastair M Thompson, Gloria V Echeverria, Stacy L Moulder, W Fraser Symmans, Jeffrey T Chang, Helen Piwnica-Worms

Faculty, Staff and Student Publications

Triple-negative breast cancer (TNBC) that fails to respond to neoadjuvant chemotherapy (NACT) can be lethal. Developing effective strategies to eradicate chemoresistant disease requires experimental models that recapitulate the heterogeneity characteristic of TNBC. To that end, we established a biobank of 92 orthotopic patient-derived xenograft (PDX) models of TNBC from the tumors of 75 patients enrolled in the ARTEMIS clinical trial (NCT02276443), including 12 longitudinal sets generated from serial patient biopsies collected throughout NACT treatment and from metastatic disease. Models were established from both chemosensitive and chemoresistant tumors, and nearly 30% of the PDX models were capable of metastasizing …


Electrochemical Breath Sensors In Medical Diagnostics: Emerging Trends And Future Directions, Natalie E. Strom, Courtney J. Weber, Olja Simoska Nov 2025

Electrochemical Breath Sensors In Medical Diagnostics: Emerging Trends And Future Directions, Natalie E. Strom, Courtney J. Weber, Olja Simoska

Faculty Publications

With the rising prevalence of metabolic diseases, infections, and mental health disorders, there is a growing demand for noninvasive diagnostic tools that enable early detection and continuous health monitoring. In this context, exhaled breath biomarkers provide insight into physiological and pathological processes. Electrochemical breath sensors (EBSs) have emerged as a promising platform for rapid, real-time, and cost-effective disease tracking via the detection of volatile breath biomarkers, such as NH3, NO, and CO2. Recent advancements in electrode materials, biological recognition elements, and sensor architectures—spanning nanomaterials, enzymes, aptamers, and molecularly imprinted polymers—have enhanced the analytical performance of EBSs. …


Electrochemical Breath Sensors In Medical Diagnostics: Emerging Trends And Future Directions, Natalie E. Strom, Courtney J. Weber, Olja Simoska Nov 2025

Electrochemical Breath Sensors In Medical Diagnostics: Emerging Trends And Future Directions, Natalie E. Strom, Courtney J. Weber, Olja Simoska

Faculty Publications

With the rising prevalence of metabolic diseases, infections, and mental health disorders, there is a growing demand for noninvasive diagnostic tools that enable early detection and continuous health monitoring. In this context, exhaled breath biomarkers provide insight into physiological and pathological processes. Electrochemical breath sensors (EBSs) have emerged as a promising platform for rapid, real-time, and cost-effective disease tracking via the detection of volatile breath biomarkers, such as NH3, NO, and CO2. Recent advancements in electrode materials, biological recognition elements, and sensor architectures—spanning nanomaterials, enzymes, aptamers, and molecularly imprinted polymers—have enhanced the analytical performance of EBSs. …


Ireland Blossoms Through Multiculturalism - Designing For Community Connection, Julia Kuczera, Shirley Casey, Hilary Kenna Nov 2025

Ireland Blossoms Through Multiculturalism - Designing For Community Connection, Julia Kuczera, Shirley Casey, Hilary Kenna

SURE Journal: Science Undergraduate Research Experience Journal

No abstract provided.


Assessing Demand And Simulating Feasibility For Commuter Rail In Lagging Regional Areas. Case Study: Sligo, Holly Briere-Edney, Brian Mccann Nov 2025

Assessing Demand And Simulating Feasibility For Commuter Rail In Lagging Regional Areas. Case Study: Sligo, Holly Briere-Edney, Brian Mccann

SURE Journal: Science Undergraduate Research Experience Journal

No abstract provided.


Resonant Breathwork As Multimodal Vagal–Interoceptive Modulation: An Empirical Synthesis Of Non-Invasive Vns, Breathing-Driven Interoception And Respiratory Tools, Piper Hutson, James Hutson Nov 2025

Resonant Breathwork As Multimodal Vagal–Interoceptive Modulation: An Empirical Synthesis Of Non-Invasive Vns, Breathing-Driven Interoception And Respiratory Tools, Piper Hutson, James Hutson

Faculty Scholarship

Resonant Breathwork is proposed as a layered, measurable intervention that modulates vagal activity and interoceptive processing through acoustic vocalization, respiratory mechanics, and biofeedback. This review synthesizes human empirical studies from 2022–2025 across five domains: (1) noninvasive transcutaneous auricular vagus nerve stimulation and acoustic or vocal vagal engagement; (2) interoception targets modulated by breathing; (3) respiratory rehabilitation tools, including oscillatory positive expiratory pressure and inspiratory muscle training; (4) virtual or augmented reality breath biofeedback; and (5) neuroimaging of high ventilation breathwork with music. Evidence shows taVNS can acutely increase vagal indices, with effects contingent on frequency and pulse width, while paced …


Nebline, November/December 2025 Nov 2025

Nebline, November/December 2025

NEBLINE Newsletter Archive from Nebraska Extension in Lancaster County

Contents

Nebraska Extension celebrates 25 years of nutrition school enrichment kits

Recipe of the month: Fruit & yogurt parfait

Celebrating the season with American persimmon by Rachel Anderson

Love gardening? Become a master gardener by Mary Jane Frogge

Extension master gardener volunteer spotlight: Carol Rustad

Garden guide: Things to do this month by Mary Jane Frogge

Choosing child care: What parents should know by Jaci Foged

Commercial/noncommercial pesticide license

Little black bugs, big bite by Kait Chapman [about pirate bugs]

What you need to know about having a well drilled by Becky Schuerman

2026 nebraska custom rates survey by Glennis …


Flea News 96 (November 2025), R. L. Bossard Nov 2025

Flea News 96 (November 2025), R. L. Bossard

Flea News

Flea News is a twice-yearly newsletter about fleas (Siphonaptera). Before including in publications any of the citations given here, please review for accuracy and correct formatting. Many of our sources are abstracting journals and current literature sources, and editors have not necessarily checked citations.

Announcements

Obituary: Lane Douglas Foil (June 16, 1949 - June 22, 2025)

Siphonaptera Literature (2025): Taxonomy, Conservation, Hosts and Distributions, Physiology and Morphology, Evolution, Ecology, Pathology and Control, Microbial Symbionts


Identifying Superior Finger Millet (Eleusine Coracana L.) Landraces Using The Multi-Trait Genotype-Ideotype Distance Index (Mgidi), Sujan Chapagaina, Bishnu Prasad Kandela, Sudikshya Shresthaa, Ankur Poudela, Shubh Pravat Singh Yadavb Nov 2025

Identifying Superior Finger Millet (Eleusine Coracana L.) Landraces Using The Multi-Trait Genotype-Ideotype Distance Index (Mgidi), Sujan Chapagaina, Bishnu Prasad Kandela, Sudikshya Shresthaa, Ankur Poudela, Shubh Pravat Singh Yadavb

Extension Publications

Genetic variability and selection are crucial for finger millet breeding programs to maximize genetic gain and productivity. This study evaluated 18 finger millet landraces cultivated in the mid-hills of Nepal, along with ‘Kavre Kodo 2’ as a check variety, assessing 14 agro-morphological traits. The objective was to identify superior finger millet landraces using a multivariate approach based on the multi-trait genotype– ideotype distance index (MGIDI). The experiment was conducted in a randomized complete block design (RCBD) with three replications. Principal component analysis revealed that the first five components collectively accounted for 80.8% of the total variation, reflecting the genetic relatedness …


Gamma Sigma Delta, Nebraska Chapter Newsletter, Issue #68 November 2025 Nov 2025

Gamma Sigma Delta, Nebraska Chapter Newsletter, Issue #68 November 2025

Gamma Sigma Delta, Nebraska Chapter: Newsletters

President's message, Deb VanOverbeke
Membership Information
2025 Outstanding Graduate Student Award Nomination Solicitation
2025 Teaching Award nomination solicitation
2025 Research Award nomination solicitation
2025 Extension Award nomination solicitation
2025 Award of Merit nomination solicitation
Gamma Sigma Delta Committees 2025
Annual Dues Notice
Membership Info and Dues
Student Award Fund solicitation
In Memoriam: Wayne W. Oberg (September 8, 1948 - February 21, 2025); Robert M. "Bob" Scriven (June 26, 1936 - August 29, 2025)
Pledge and Honor Cords
Save the Date: Initiation and Awards Reception


Living Shoreline Prioritization And Hydrodynamic Habitat Suitability Models For Restoration In The Indian River Lagoon And Lake Worth Lagoon, Florida, Kelly M. Kibler, Melinda J. Donnelly, Vincent Encomio, Madison Giuntoli, Manisha Thenuwara, Brice Bennett, Laura Andrade Barron, Mariam Sonbol, Wynter Raine Seppala, Namritha Ramakrishnan, Jennifer Jordan Báez, Beth Orlando, Irene Arpayoglou, Melissa Meisenburg Nov 2025

Living Shoreline Prioritization And Hydrodynamic Habitat Suitability Models For Restoration In The Indian River Lagoon And Lake Worth Lagoon, Florida, Kelly M. Kibler, Melinda J. Donnelly, Vincent Encomio, Madison Giuntoli, Manisha Thenuwara, Brice Bennett, Laura Andrade Barron, Mariam Sonbol, Wynter Raine Seppala, Namritha Ramakrishnan, Jennifer Jordan Báez, Beth Orlando, Irene Arpayoglou, Melissa Meisenburg

Indian River Lagoon Shorelines

The spatial dataset: UCF_shorelinemodel_IRL_LWL.shp, was created with support from the Indian River Lagoon National Estuaries Program and Florida Sea Grant. These projects cumulatively led to creation of a living shoreline restoration prioritization model and hydrodynamic habitat suitability models for 1,550 km (963 miles) of estuarine shorelines in Indian River Lagoon and Lake Worth Lagoon.

The dataset presented herein includes:

  1. shoreline data from >15,000 transects collected in the field,
  2. shoreline wave climate data created through hydrodynamic modeling and frequency analysis of historic data,
  3. categorization of potential risk for shoreline boat wake impact,
  4. persistence of seagrass within 210 m of the shoreline, …


3d Printed Microscopes As A Low-Cost Alternative To Conventional Light Microscopes, Aidan W. Donelan, Hunter N. Lemer, Sudeshna Roy, Nicholas C. Butzin Nov 2025

3d Printed Microscopes As A Low-Cost Alternative To Conventional Light Microscopes, Aidan W. Donelan, Hunter N. Lemer, Sudeshna Roy, Nicholas C. Butzin

iLEARN Teaching Resources

Many K-12 schools function on limited budgets in their science departments, making it difficult to acquire, maintain, and update microscopes. While modern light microscopes are often complex, expensive, and require specialized training, they are based on simple principles of light. Microscopes enable us to observe objects too small for the naked eye and reveal intricate details. Introducing affordable, easy-to-use microscope adaptations early in education helps foster a deeper understanding of science and encourages young students to pursue STEM fields. Using 3D printing, we developed two innovative microscope models and two lesson plans. Lesson 1: Using a smartphone microscope to visualize …


A Comprehensive Overview Of Chronic Wound Infections And Current Treatment Methods, Sarah Fakher, David J. Westenberg Nov 2025

A Comprehensive Overview Of Chronic Wound Infections And Current Treatment Methods, Sarah Fakher, David J. Westenberg

Biological Sciences Faculty Research & Creative Works

Chronic wound infections pose significant healthcare challenges due to persistent biofilms, antibiotic resistance, and impaired healing pathways. These wounds are characterized by prolonged inflammation, microbial colonization, and disrupted tissue regeneration, leading to substantial morbidity and healthcare costs. This article reviews current knowledge on chronic wound types, their pathophysiology, and the mechanisms underlying biofilm formation to examine the latest advancements in antimicrobial-based strategies aimed at addressing these challenges. It highlights how diverse materials and technologies have been engineered to improve infection management, enhance tissue regeneration, and overcome the limitations of traditional treatments as well as advances that leverage innovations such as …


‘Earth System Engineers’ And The Cumulative Impact Of Organisms In Deep Time, Simon A. F. Darroch, Michelle M. Casey, Alison T. Cribb, Amanda E. Bates, Matthew E. Clapham, Dori L. Contreras, Matthew Craffey, Ivo A. P. Duijnstee, William Gearty, Nicholas J. Gotelli, Marcus J. Hamilton, Riley F. Hayes, Pincelli M. Hull, Daniel E. Ibarra, V. A. Korasidis, Jaemin Lee, Cindy V. Looy, Tyler R. Lyson, Benjamin Muddiman, Peter D. Roopnarine, Alex B. Shupinski, Felisa A. Smith, Alycia L. Stigall, Catalina P. Tomé, Katherine A. Turk, Amelia Villaseñor, Peter J. Wagner, Steve C. Wang, S. Kathleen Lyons Nov 2025

‘Earth System Engineers’ And The Cumulative Impact Of Organisms In Deep Time, Simon A. F. Darroch, Michelle M. Casey, Alison T. Cribb, Amanda E. Bates, Matthew E. Clapham, Dori L. Contreras, Matthew Craffey, Ivo A. P. Duijnstee, William Gearty, Nicholas J. Gotelli, Marcus J. Hamilton, Riley F. Hayes, Pincelli M. Hull, Daniel E. Ibarra, V. A. Korasidis, Jaemin Lee, Cindy V. Looy, Tyler R. Lyson, Benjamin Muddiman, Peter D. Roopnarine, Alex B. Shupinski, Felisa A. Smith, Alycia L. Stigall, Catalina P. Tomé, Katherine A. Turk, Amelia Villaseñor, Peter J. Wagner, Steve C. Wang, S. Kathleen Lyons

College of Life Sciences Faculty Papers

Understanding the role of humans as 'ecosystem engineers' requires a deep-time perspective rooted in evolutionary history and the fossil record. However, no conceptual framework exists for studying the rise of ecosystem engineering in deep time, requiring us to consider effects that fall outside the scope of traditional definitions. Here, we present a new framework applicable to both modern and ancient engineering-type effects. We propose a new term - 'Earth system engineering' - to describe biological processes that alter the structure and function of planetary spheres, and which combines core tenets of ecosystem engineering, niche construction, and legacy effects. We illustrate …


Detection And Classification Of Invasive Callery Pear From Multisource Satellite Imageries In Google Earth Engine, Kavi Raj Awasthi, Nilesh Timilsina, Denita Hadziabdic, Federico Iuricich, William E. Klingeman, Marcin Nowicki, Brook T. Russell, Jessica A. Hartshorn Nov 2025

Detection And Classification Of Invasive Callery Pear From Multisource Satellite Imageries In Google Earth Engine, Kavi Raj Awasthi, Nilesh Timilsina, Denita Hadziabdic, Federico Iuricich, William E. Klingeman, Marcin Nowicki, Brook T. Russell, Jessica A. Hartshorn

Publications

Assessing the spatial distribution of invasive species is a critical component for establishing baselines to examine the rate of spread, documenting key areas where negative impacts on ecosystems can be mitigated, and developing sustainable management strategies. Callery pear (Pyrus calleryana Decne.; PC) is a rapidly spreading invasive woody plant species in the eastern United States (U.S.). The incursion of these wild-type trees into urban, peri-urban, and rural landscapes, which have escaped from transplanted clonal cultivars, poses complex management challenges for land managers and hampers ecosystem function by competing with native plant species and altering the forest environment. We integrated …


Multilevel Selection In The Margins: A Review Of Its Representation In Undergraduate Biology Textbooks, C. A. Greene, S. J. Mcpeek, L. Mitchem, A. B. Clark, Vincent A. Formica Nov 2025

Multilevel Selection In The Margins: A Review Of Its Representation In Undergraduate Biology Textbooks, C. A. Greene, S. J. Mcpeek, L. Mitchem, A. B. Clark, Vincent A. Formica

Biology Faculty Works

Multilevel selection (MLS) is a foundational framework that expands the concept of natural selection beyond the traditional focus on individuals or genes to larger units, like groups. Despite strong empirical support and applications in a broad range of biological fields, MLS, often referred to as group selection, has a controversial history, which has impeded its wide use and led to incorrect inferences on the sources and strength of selection. Here, we explore how MLS is currently presented to undergraduate biology students by analyzing the content of nine commonly used Evolutionary Biology and Animal Behavior textbooks. We ask whether and how …


Ai Recipe Blog Is Evaluated Similarly To A Recipe Blog Created By Nutrition And Dietetic Students, Katie N. Kraus, Stacy L. Bevan, Sarah Moore Smith, Maeci H. Armstrong, Brooke Campbell Jeppesen, Catherine Fish, Heidi J. Wengreen Nov 2025

Ai Recipe Blog Is Evaluated Similarly To A Recipe Blog Created By Nutrition And Dietetic Students, Katie N. Kraus, Stacy L. Bevan, Sarah Moore Smith, Maeci H. Armstrong, Brooke Campbell Jeppesen, Catherine Fish, Heidi J. Wengreen

Nutrition, Dietetics, and Food Sciences Faculty Publications

With the growing use of AI, it is important to know target audiences’ perceptions of its use. A convenience sample of students were invited to take an online survey in which they were randomly assigned to Group 1 (evaluated a student-generated blog; n = 456) or Group 2 (evaluated an AI-generated blog; n = 492). The results of independent t-tests and chi-squared tests indicated no group differences in ratings of ease of recipe preparation, time to prepare the recipe, utilization of common ingredients, and frequency of intended use of the blog. The student-generated blog was rated higher on budget …


Developing Hydrophobic-Hydrophilic Protein Structures By 3d Food Printing Of Sorghum And Soy Protein Gels, Sorour Barekat, Ali Ubeyitogullari Nov 2025

Developing Hydrophobic-Hydrophilic Protein Structures By 3d Food Printing Of Sorghum And Soy Protein Gels, Sorour Barekat, Ali Ubeyitogullari

Food Science Faculty Publications and Presentations

The goal of this study was to introduce the simultaneous use of hydrophobic-hydrophilic proteins bioinks for 3D food printing. Sorghum protein gel (SPG) at 25 % w/w and soy protein isolate gel (SPIG) at 11 % w/w were loaded into separate extruders. The effects of the first printed layer (SPG or SPIG), printing speed (10, 20 mm/s), and nozzle size (0.52, 0.64, 0.72 mm) on printability were evaluated. The textural properties, rheological characteristics, microstructure, crystallinities, and functional groups of the proteins were analyzed. Printing sorghum and soy proteins together helped balance essential amino acids, where lysine (94.7 %) and histidine …


The Role Of Fungal Proteases In Bioactive Peptide Production And Analytical Approaches For Tracking Their Activity, Tanvir Ahmed, Angéla Juhász, Utpal Bose, Netsane Shiferaw Terefe, Michelle L. Colgrave Nov 2025

The Role Of Fungal Proteases In Bioactive Peptide Production And Analytical Approaches For Tracking Their Activity, Tanvir Ahmed, Angéla Juhász, Utpal Bose, Netsane Shiferaw Terefe, Michelle L. Colgrave

Research outputs 2022 to 2026

Fungal proteases catalyse site-specific peptide bond cleavage in complex protein matrices, enabling bioactive peptide (BP) release. Accurate monitoring is vital for optimising hydrolysis efficiency, minimising nonspecific proteolysis, ensuring consistent yields, and preserving peptide biofunctionality. While analytical and computational tools are well-established for non-fungal systems, their adaptation to fungal proteases remains exploratory, with no comprehensive evaluation addressing the unique challenges in this field. This review synthesises current knowledge, identifies methodological gaps, and outlines future directions for developing fungi-specific analytical pipelines and computational frameworks for BP discovery. It explores fungal protease families, their roles in intracellular peptide processing, and fungal survival strategies. …


Substituted Piperidines As (Alpha4)3(Beta2)2 Nicotinic Acetylcholine Receptor Positive Allosteric Modulators: In Vitro Pharmacology, Nataly Sanchez, Josue Gaona, Wilder Felix, Nathalia Menegasso, Brisa Cea, Ganesh Thakur, Ayman K. Hamouda Nov 2025

Substituted Piperidines As (Alpha4)3(Beta2)2 Nicotinic Acetylcholine Receptor Positive Allosteric Modulators: In Vitro Pharmacology, Nataly Sanchez, Josue Gaona, Wilder Felix, Nathalia Menegasso, Brisa Cea, Ganesh Thakur, Ayman K. Hamouda

School of Medicine Student Publications and Presentations

Nicotinic acetylcholine receptors (nAChRs) play a crucial role in the pathogenesis of neurodegenerative diseases such as Parkinsonʼs disease (PD). In PD, degeneration of dopaminergic and cholinergic neurons impairs neurotransmitter release, leading to cognitive and motor dysfunction. Current treatments provide only symptomatic relief, highlighting the need for novel therapeutic strategies. The (α4)₃(β2)₂ subtype of nAChRs is expressed on affected neurons, making it a promising druggable target for enhancing neurotransmitter release and providing neuroprotection. To explore the therapeutic potential of positive allosteric modulators (PAMs) of (α4)₃(β2)₂ nAChRs, we evaluated chemical derivatives of CMPI [3-(2-chlorophenyl)-5-(5-methyl-1-(piperidin-4-yl)-1H-pyrazol-4-yl)isoxazole]. We used two-electrode voltage-clamp recordings from Xenopus laevis …


Enhancement Of Antimicrobial Activity Of Truncated Cecropin B Peptides With The Substitution Of Tryptophan Residues, Sarah Smith, Christopher Feudale, Josephina R. Vermillion, Joseph Feudale, Joshua Do, Sabrina Arroyo, Juan Barrera, Madeleine Whitsitt, Marion Duval, Colby Grames, Bret Hatzinger, Makenzie Hilling, Tia Kean, Jasayle Rivera, Mia Shum, Hannah Zyra, David Rovnyak, Moria C. Chambers Nov 2025

Enhancement Of Antimicrobial Activity Of Truncated Cecropin B Peptides With The Substitution Of Tryptophan Residues, Sarah Smith, Christopher Feudale, Josephina R. Vermillion, Joseph Feudale, Joshua Do, Sabrina Arroyo, Juan Barrera, Madeleine Whitsitt, Marion Duval, Colby Grames, Bret Hatzinger, Makenzie Hilling, Tia Kean, Jasayle Rivera, Mia Shum, Hannah Zyra, David Rovnyak, Moria C. Chambers

Faculty Journal Articles

Cecropins are a class of antimicrobial peptides (AMPs) expressed by insects that have broad-spectrum antimicrobial activity and low cytotoxicity. However, cecropins are also long (40–45 amino acids) peptides, making their adaptation for therapeutic use challenging. Here, we present a series of 16 amino acid-long peptides derived from cecropin B from Drosophila melanogaster. The native truncated peptide is cationic and expected to form an amphipathic α-helix, but does not have antimicrobial activity. The incorporation of two Trp residues, depending on the position in the peptide backbone, results in antibacterial activity compa-rable to that of full-length cecropin B against the gram-negative bacteria …


Marine Environmental Protection : An Investigation Into Existing Global Laws Addressing Marine Plastic Pollution, Maryland De Castro Nov 2025

Marine Environmental Protection : An Investigation Into Existing Global Laws Addressing Marine Plastic Pollution, Maryland De Castro

World Maritime University Dissertations

No abstract provided.


Evaluating The Fisheries Observer Program Of Guyana’S Seabob Trawl Fishery : Insights Into Scientific Aspects And Onboard Working Conditions, Kadesha Shawyana Nedd Nov 2025

Evaluating The Fisheries Observer Program Of Guyana’S Seabob Trawl Fishery : Insights Into Scientific Aspects And Onboard Working Conditions, Kadesha Shawyana Nedd

World Maritime University Dissertations

No abstract provided.


Expanding Functionalities Of Immune Receptors Through Simultaneous Transfer Of Sensor And Helper Nlrs, Dongjiao Wang, Qibin Wu, Daowen Wang, Youxiong Que, Zheng Qing Fu Nov 2025

Expanding Functionalities Of Immune Receptors Through Simultaneous Transfer Of Sensor And Helper Nlrs, Dongjiao Wang, Qibin Wu, Daowen Wang, Youxiong Que, Zheng Qing Fu

Faculty Publications

No abstract provided.


Preparedness And Response To Oil And Biofuel Spills : A Case Study Of The Western Indian Ocean, Soifoine Abdillah Nov 2025

Preparedness And Response To Oil And Biofuel Spills : A Case Study Of The Western Indian Ocean, Soifoine Abdillah

World Maritime University Dissertations

No abstract provided.


Assessing Spatial And Temporal Patterns Of Industrial Bottom Trawlers Using Vessel Monitoring System Data : A Case Study Of Ghana, Emmanuel Agbeko Nov 2025

Assessing Spatial And Temporal Patterns Of Industrial Bottom Trawlers Using Vessel Monitoring System Data : A Case Study Of Ghana, Emmanuel Agbeko

World Maritime University Dissertations

No abstract provided.