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Articles 9061 - 9090 of 159698
Full-Text Articles in Entire DC Network
Melanaphis Sacchari/Sorghi Complex: Current Status, Challenges And Integrated Strategies For Managing The Invasive Sap-Feeding Insect Pest Of Sorghum, Alejandro Vasquez, Joseph Belsky, Neetu Khanal, Heena Puri, Devi Balakrishnan, Neelendra K. Joshi, Joe Louis, Glenn Studebaker, Rupesh Kariyat
Melanaphis Sacchari/Sorghi Complex: Current Status, Challenges And Integrated Strategies For Managing The Invasive Sap-Feeding Insect Pest Of Sorghum, Alejandro Vasquez, Joseph Belsky, Neetu Khanal, Heena Puri, Devi Balakrishnan, Neelendra K. Joshi, Joe Louis, Glenn Studebaker, Rupesh Kariyat
School of Integrative Biological & Chemical Sciences (Formerly Dept. of Biology)
Melanaphis sacchari (Zehntner;Hemiptera: Aphididae), sugarcane aphid (SCA), is an invasive phloem-feeder found worldwide with a wide host range of economically important plants including sorghum and sugarcane. Given its high reproductive capacity and ability to rapidly spread over long distances, SCA presents challenges for effective control, leading to substantial economic losses. Recent studies have identified two multiloci SCA genotypes specialized in feeding on sugarcane (MLL-D) and sorghum (MLL-F) in the USA, which raises concerns as the USA is the second largest sorghum-producing country. This has encouraged research towards identifying these two biotypes where some research has stated them as two species; …
A Qualitative Nmr And Histological Analysis Of Adipocere Formation In Different Aqueous Environments Using Sus Scrofa Models, Mia M. Sorrentino
A Qualitative Nmr And Histological Analysis Of Adipocere Formation In Different Aqueous Environments Using Sus Scrofa Models, Mia M. Sorrentino
Student Theses
Adipocere is a wax-like crust that has the potential to form over corpses in moist, humid, and anaerobic environments, preserving them in a process similar to that of mummification. The substance can be identified within 3-6 months postmortem and is characterized by the ratio of saturated fatty acids to unsaturated fatty acids. Palmitic acid and stearic acid are the most abundant in comparison to myristic and oleic acids. The goal of this study was to investigate factors affecting adipocere formation in different aqueous environments. Pork belly samples were submerged in water samples collected from different places around New York City …
Developing A Small Molecule To Inhibit Hsf1 Expression In Cancer And Evaluating Natural Genetic Variation In Small Molecule Toxicity., Michaela Kendal Foley
Developing A Small Molecule To Inhibit Hsf1 Expression In Cancer And Evaluating Natural Genetic Variation In Small Molecule Toxicity., Michaela Kendal Foley
Theses and Dissertations
Each year cancer affects nearly 20 million people worldwide and genetic differences across populations can impact cancer onset and progression. Specifically, tumors with high levels of HSF1, the master regulator of the cytoprotective heat shock response (HSR), are correlated with poor patient outcomes in multiple cancers such as prostate, breast, and melanoma. Subsequently, the development of pharmacological inhibitors of HSF1 represents a promising strategy for anticancer therapeutics. Using a luciferase-based transcriptional reporter, two small molecule libraries were screened for inhibitors of HSF1 expression in human embryonic kidney cells, yielding ten compounds that decrease HSF1 expression. To identify if cancer lines …
The Contribution Of De Novo Coding Mutations To Meningomyelocele, Yoo-Jin Jiny Ha, Ashna Nisal, Isaac Tang, Chanjae Lee, Ishani Jhamb, Cassidy Wallace, Robyn Howarth, Sarah Schroeder, Keng Ioi Vong, Naomi Meave, Fiza Jiwani, Chelsea Barrows, Sangmoon Lee, Nan Jiang, Arzoo Patel, Krisha Bagga, Niyati Banka, Liana Friedman, Francisco A Blanco, Seyoung Yu, Soeun Rhee, Hui Su Jeong, Isaac Plutzer, Michael B Major, Béatrice Benoit, Christian Poüs, Caleb Heffner, Zoha Kibar, Gyang Markus Bot, Hope Northrup, Kit Sing Au, Madison Strain, Allison E Ashley-Koch, Richard H Finnell, Joan T Le, Hal S Meltzer, Camila Araujo, Helio R Machado, Roger E Stevenson, Anna Yurrita, Sara Mumtaz, Awais Ahmed, Mulazim Hussain Khara, Osvaldo M Mutchinick, José Ramón Medina-Bereciartu, Friedhelm Hildebrandt, Gia Melikishvili, Ahmed I Marwan, Valeria Capra, Mahmoud M Noureldeen, Aida M S Salem, Mahmoud Y Issa, Maha S Zaki, Libin Xu, Ji Eun Lee, Donghyuk Shin, Anna Alkelai, Alan R Shuldiner, Stephen F Kingsmore, Stephen A Murray, Heon Yung Gee, W Todd Miller, Kimberley F Tolias, John B Wallingford, Spina Bifida Sequencing Consortium, Sangwoo Kim, Joseph G Gleeson
The Contribution Of De Novo Coding Mutations To Meningomyelocele, Yoo-Jin Jiny Ha, Ashna Nisal, Isaac Tang, Chanjae Lee, Ishani Jhamb, Cassidy Wallace, Robyn Howarth, Sarah Schroeder, Keng Ioi Vong, Naomi Meave, Fiza Jiwani, Chelsea Barrows, Sangmoon Lee, Nan Jiang, Arzoo Patel, Krisha Bagga, Niyati Banka, Liana Friedman, Francisco A Blanco, Seyoung Yu, Soeun Rhee, Hui Su Jeong, Isaac Plutzer, Michael B Major, Béatrice Benoit, Christian Poüs, Caleb Heffner, Zoha Kibar, Gyang Markus Bot, Hope Northrup, Kit Sing Au, Madison Strain, Allison E Ashley-Koch, Richard H Finnell, Joan T Le, Hal S Meltzer, Camila Araujo, Helio R Machado, Roger E Stevenson, Anna Yurrita, Sara Mumtaz, Awais Ahmed, Mulazim Hussain Khara, Osvaldo M Mutchinick, José Ramón Medina-Bereciartu, Friedhelm Hildebrandt, Gia Melikishvili, Ahmed I Marwan, Valeria Capra, Mahmoud M Noureldeen, Aida M S Salem, Mahmoud Y Issa, Maha S Zaki, Libin Xu, Ji Eun Lee, Donghyuk Shin, Anna Alkelai, Alan R Shuldiner, Stephen F Kingsmore, Stephen A Murray, Heon Yung Gee, W Todd Miller, Kimberley F Tolias, John B Wallingford, Spina Bifida Sequencing Consortium, Sangwoo Kim, Joseph G Gleeson
Faculty, Staff and Students Publications
Meningomyelocele (also known as spina bifida) is considered to be a genetically complex disease resulting from a failure of the neural tube to close. Individuals with meningomyelocele display neuromotor disability and frequent hydrocephalus, requiring ventricular shunting. A few genes have been proposed to contribute to disease susceptibility, but beyond that it remains unexplained1. We postulated that de novo mutations under purifying selection contribute to the risk of developing meningomyelocele2. Here we recruited a cohort of 851 meningomyelocele trios who required shunting at birth and 732 control trios, and found that de novo likely gene disruption or …
Ecological Specialisation Of Reef Fishes Peaks In Global Biodiversity Hotspots, Zoé Delecambre, Renato A. Morais, Alexandre C. Siqueira, Emma Paul Costesec, Caroline E. Dubé, Sergio R. Floeter, Alan M. Friedlander, Fabien Leprieur, Yves Letourneur, Lucas T. Nunes, Jordan M. Casey, Valeriano Parravicini
Ecological Specialisation Of Reef Fishes Peaks In Global Biodiversity Hotspots, Zoé Delecambre, Renato A. Morais, Alexandre C. Siqueira, Emma Paul Costesec, Caroline E. Dubé, Sergio R. Floeter, Alan M. Friedlander, Fabien Leprieur, Yves Letourneur, Lucas T. Nunes, Jordan M. Casey, Valeriano Parravicini
Research outputs 2022 to 2026
Aim: The role of ecological specialisation in shaping biogeographic and evolutionary patterns remains unresolved. To date, few studies have quantitatively examined consumer niche breadth at a global scale. We describe global biogeographic and diversification patterns of specialisation, measured using trophic and thermal niches, for a highly diverse assemblage of consumers: reef fishes. First, we investigated the confluence of specialisation with global biogeographic patterns in species richness and reef area. Then, we tested whether these patterns could be explained by differences in diversification rates and geographic ranges. Location: Tropical reefs across the globe. Time Period: Present. Major Taxa Studied: Reef fishes. …
Revised Phylogeography Of The Common Brushtail Possum (Trichosurus Vulpecula) Reveals New Insights Into Genetic Structure Across Australia, Shelby C. Middleton, Robert A. Davis, Kenny J. Travouillon, Anna J.M. Hopkins, Harriet R. Mills, Linette S. Umbrello
Revised Phylogeography Of The Common Brushtail Possum (Trichosurus Vulpecula) Reveals New Insights Into Genetic Structure Across Australia, Shelby C. Middleton, Robert A. Davis, Kenny J. Travouillon, Anna J.M. Hopkins, Harriet R. Mills, Linette S. Umbrello
Research outputs 2022 to 2026
Understanding genetic relationships within species is essential for identifying distinct genetic lineages and informing conservation strategies, particularly for species with fragmented or widespread geographic distributions. One such widespread species that has suffered declines across Australia, despite remaining common in some areas, is the common brushtail possum (Trichosurus vulpecula), a nocturnal and arboreal marsupial. Previous genetic studies on brushtail possums had limited sampling, which has precluded a comprehensive assessment of the relationships within the species and genus. Using both single nucleotide polymorphism markers and the mitochondrial cytochrome b gene, this study employed phylogenetics, ancestry coefficients, and tested genetic differentiation, to examine …
Structure Disorder And Magnetic Behavior Of An Olivine-Type Cathode Material, Hamida Hassan, Madalynn Marshall
Structure Disorder And Magnetic Behavior Of An Olivine-Type Cathode Material, Hamida Hassan, Madalynn Marshall
Symposium of Student Scholars
Our research investigates the structure disorder and magnetic behavior of Li(Mn,Fe)PO₄, an olivine-type material relevant for lithium-ion battery applications. Using single-crystal neutron diffraction at Oak Ridge National Laboratory, we precisely determined Mn and Fe occupancy, revealing a 56% Fe and 44% Mn distribution at the atomic 4c site within the Pnma space group. Additionally, we observed significant lithium site vacancies (78% occupied), influencing the material's electrochemical and magnetic properties. The varying Mn/Fe ratio affected spin reorientation transitions, shifting from antiferromagnetic alignment along the a-axis to the b-axis. Our findings provide crucial insights for optimizing olivine-based cathodes, enhancing energy …
Assessing The Osmoregulatory Capabilities Of American Alligator Lingual Glands, Benjamin Angalet, Nicholas S. Green
Assessing The Osmoregulatory Capabilities Of American Alligator Lingual Glands, Benjamin Angalet, Nicholas S. Green
Symposium of Student Scholars
Crocodilians inhabit a wide variety of aquatic, marine, and estuarine habitats on 4 continents. Saltwater-adapted species and populations face considerable osmoregulatory challenges in maintaining homeostasis with respect to plasma salt [NaCl] concentration. In addition to the kidneys and cloaca found in all crocodilians, crocodiles possess a salt-secreting lingual gland whose presence and function is less understood in other crocodilians. This study investigates the lingual gland anatomy, physiology, and potential function of American alligator (Alligator mississippiensis) populations exposed to varying salinity levels. At each of four sites (Jekyll Island, Sapelo Island, Okefenokee NWR, and Banks Lake NWR), we will capture 12 …
Can A Ceh-27/Nkx2.1 Transgene Rescue Ceh-27 Neurodevelopmental Defects?, Meryl Gilmore, Martin L. Hudson
Can A Ceh-27/Nkx2.1 Transgene Rescue Ceh-27 Neurodevelopmental Defects?, Meryl Gilmore, Martin L. Hudson
Symposium of Student Scholars
When the development of an organism’s nervous system is interrupted or altered, it can significantly impact that organism’s ability to survive and function properly. In our lab, we use a species of nematode called Caenorhabditis elegans as a model organism to characterize the roles of important transcription factors in human neurodevelopmental disorders such as attention deficit hyperactivity disorder (ADHD). Utilizing C. elegans makes analyzing this process in a lab very easy for many reasons; they are very small, have a rapid life cycle, invariant cell lineage, transparent bodies, and most importantly, around 80% of their genes have human orthologs. In …
Predicting Healthcare Service Quality Based On A Kalman-Optimized Bi-Lstm-Inspired Deep Learning Model, Mohammed K. Al-Khafaji, Eman S. Al-Shamery
Predicting Healthcare Service Quality Based On A Kalman-Optimized Bi-Lstm-Inspired Deep Learning Model, Mohammed K. Al-Khafaji, Eman S. Al-Shamery
Karbala International Journal of Modern Science
Health is one of the most important aspects of human well-being, and access to high-quality healthcare is essential for a good quality of life. Providing top-level health services at all times is crucial. However, the research in healthcare poses significant challenges due to the diversity and variations of medical practices across different hospitals. This paper aims to tackle the challenge of data missing and scattering during data collection. Then, the quality of services (QoS) offered by healthcare facilities will be analyzed and predicted from the patient's perspective. The model begins preprocessing data by data cleaning, handling missing values, and scattering …
Assessing The Behavioral Impact Of Pyridostigmine Bromide In Rats, Noah A. Martin
Assessing The Behavioral Impact Of Pyridostigmine Bromide In Rats, Noah A. Martin
Honors Theses
Pyridostigmine bromide (PB) is an organophosphate (OP) nerve agent prophylactic used to protect warfighters against chemical warfare agents. OPs inhibit the neural enzyme acetylcholinesterase (AChE) in the brain. This leads to the buildup of acetylcholine, causing respiratory failure, seizures, and death. PB functions by inhibiting ~30% of peripheral AChE temporarily, protecting the enzymes so that the body is able to restore sufficient cholinergic function post-exposure. PB does not cross the blood-brain barrier, though it may still indirectly affect toxicity in the brain due to repeated AChE inhibition throughout treatment, or by inhibition of non-target ChE’s in the blood. The aim …
Seasonal Detection Of Coliphages In Freshwater Bodies At Coastal Carolina University, Ella Caldwell
Seasonal Detection Of Coliphages In Freshwater Bodies At Coastal Carolina University, Ella Caldwell
Honors Theses
Bacteriophages, commonly referred to as phages, are non-living viruses that only infect bacteria. As the most abundant biological entities on Earth, understanding their role in regulating microbial populations is essential. This ongoing research aims to identify naturally occurring bacteriophages that could effectively control bacteria blooms. The primary objective of this study is to detect coliphages on Coastal Carolina University's campus and determine their viral families. Coliphages are a subgroup of bacteriophages that specifically infect coliform bacteria. Water samples were collected across multiple sites on campus, and polymerase chain reaction (PCR) was employed to amplify the viral DNA from the potential …
Gonadal Absence Of Ceh-22: Degradation Of Ceh-22 In The Gonads Of Caenorhabditis Elegans, Andreya C. White
Gonadal Absence Of Ceh-22: Degradation Of Ceh-22 In The Gonads Of Caenorhabditis Elegans, Andreya C. White
Undergraduate Theses
The reproductive system of hermaphrodite Caenorhabditis elegans (C. elegans) comprises two gonadal arms, each with a terminating distal tip cell (DTC), connected by a common uterus. The DTC has two functions: leader and niche. In C. elegans, ceh-22/nkx2,5 has been found to work together with Wnt signaling to determine the fates of the DTC (Lam et al., 2006). This is an indication that ceh-22 aids in the specification of DTCs. Our research aims to determine the specific function of ceh-22 in the gonad of both male and hermaphrodite C. elegans. This will be accomplished by observing …
Can Chaperones Promote Protein Splicing?, Hazel Thomas
Can Chaperones Promote Protein Splicing?, Hazel Thomas
Honors College Theses
Inteins are a mobile genetic element hypothesized to function as regulatory molecules in microbes. They bear a homing endonuclease domain for genome traversal, as well as specific residues allowing for protein splicing. In the protein splicing reaction, the intein is removed and the flanking residues, termed exteins, are ligated together with a peptide bond to form a functional host protein. Due to their interruption prior to splicing, inteins prevent a host protein from functioning until the intein ligates the two exteins. To measure factors that regulate protein splicing in vivo, an intein-based biosensor based on kanamycin resistance (K …
Degradation Of Vascular Networks In A Huvec Model Of Dm1, Bonnie E. Butler
Degradation Of Vascular Networks In A Huvec Model Of Dm1, Bonnie E. Butler
Departmental Honors & Graduate Capstone Projects
Myotonic dystrophy type 1 (DM1) is a genetic disease that causes muscle wasting and affects multiple organ systems. DM1 is caused by expanded CTG repeats in the 3’ untranslated region of the dystrophia myotonica protein kinase (DMPK) gene (Harper, 2001). Skeletal muscle relies on capillaries for nutrient delivery and waste clearance (Olfert, 2016). Skeletal muscle and capillaries communicate via a variety of chemicals, including PDGF-BB which both skeletal muscle and endothelial cells secrete and have receptors for (Hamaguchi, 2023). Platelet derived growth factor receptor β (PDGFRβ), when bound to platelet derived growth factor BB (PDGF-BB), induces angiogenesis (Wang, 2012). In …
Raíces Y Recuerdos: Plantas Ornamentales Para Entornos Saludables, Adriana Hernández Bustos, María Janeth Camargo Garzón, María Victoria Rojas Martínez, Segundo Leonardo Cortes López
Raíces Y Recuerdos: Plantas Ornamentales Para Entornos Saludables, Adriana Hernández Bustos, María Janeth Camargo Garzón, María Victoria Rojas Martínez, Segundo Leonardo Cortes López
Ciencias de la Salud
El reino vegetal es un universo lleno de vida, colores, texturas, aromas y beneficios que trascienden a través del tiempo. Es un aliado perfecto para el trabajo conjunto e intergeneracional; para este caso, las plantas no solo embellecen los paisajes y espacios, sino que tienen además el poder de mejorar nuestra calidad de vida, especialmente cuando se integran en actividades terapéuticas y sociales con personas mayores.
Intermittent Fasting And Cardiometabolic Health In Adults With Obesity: A Scoping Review, Tri Siswati, Lathifa Zahra Putri Nugroho, Natasya Nurul Gina, Almira Sitasari, Agus Wijanarka
Intermittent Fasting And Cardiometabolic Health In Adults With Obesity: A Scoping Review, Tri Siswati, Lathifa Zahra Putri Nugroho, Natasya Nurul Gina, Almira Sitasari, Agus Wijanarka
Indonesian Journal of Public Health Nutrition (IJPHN)
Obesity is a significant global health challenge, with adverse impacts on cardiometabolic health such as hypertension, dyslipidemia, and insulin resistance. One promising intervention in obesity management is intermittent fasting (PI). However, scientific evidence on the impact of IF on cardiometabolic health is still limited. This study used a scoping review design to evaluate the association between IF and cardiometabolic health in obese adults. Reference sources are available in English at least abstract between 2015–2023 as well as from PubMed and Google Scholar web sources. The search keywords on PubMed are "Adult AND intermittent fasting AND cardiometabolic" and on Google Scholar …
Plant Diversity Dynamics Over Space And Time In A Warming Arctic, Mariana García Criado, Isla H. Myers-Smith, Anne D. Bjorkman, Sarah C. Elmendorf, Signe Normand, Peter Aastrup, Rien Aerts, Juha M. Alatalo, Lander Baeten, Robert G. Björk, Mats P. Björkman, Noémie Boulanger‐Lapointe, Ethan E. Butler, Elisabeth J. Cooper, J. Hans C. Cornelissen, Gergana N. Daskalova, Belen Fadrique, Bruce C. Forbes, Greg H. R. Henry, Robert D. Hollister, Toke Thomas Høye, Ida Bomholt Dyrholm Jacobsen, Annika K. Jägerbrand, Ingibjörg S. Jónsdóttir, Elina Kaarlejärvi, Olga Khitun, Kari Klanderud, Tiina H. M. Kolari, Simone I. Lang, Nicolas Lecomte, Jonathan Lenoir, Petr Macek, Julie Messier, Anders Michelsen, Ulf Molau, Robert Muscarella, Marie-Louise Nielsen, Matteo Petit Bon, Eric Post, Katrine Raundrup, Riikka Rinnan, Christian Rixen, Ingvild Ryde, Josep M. Serra‐Diaz, Gabriela Schaepman‐Strub, Niels M. Schmidt, Franziska Schrodt, Sofie Sjögersten, Manuel J. Steinbauer, Lærke Stewart, Beate Strandberg, Anne Tolvanen, Craig E. Tweedie, Mark Vellend
Plant Diversity Dynamics Over Space And Time In A Warming Arctic, Mariana García Criado, Isla H. Myers-Smith, Anne D. Bjorkman, Sarah C. Elmendorf, Signe Normand, Peter Aastrup, Rien Aerts, Juha M. Alatalo, Lander Baeten, Robert G. Björk, Mats P. Björkman, Noémie Boulanger‐Lapointe, Ethan E. Butler, Elisabeth J. Cooper, J. Hans C. Cornelissen, Gergana N. Daskalova, Belen Fadrique, Bruce C. Forbes, Greg H. R. Henry, Robert D. Hollister, Toke Thomas Høye, Ida Bomholt Dyrholm Jacobsen, Annika K. Jägerbrand, Ingibjörg S. Jónsdóttir, Elina Kaarlejärvi, Olga Khitun, Kari Klanderud, Tiina H. M. Kolari, Simone I. Lang, Nicolas Lecomte, Jonathan Lenoir, Petr Macek, Julie Messier, Anders Michelsen, Ulf Molau, Robert Muscarella, Marie-Louise Nielsen, Matteo Petit Bon, Eric Post, Katrine Raundrup, Riikka Rinnan, Christian Rixen, Ingvild Ryde, Josep M. Serra‐Diaz, Gabriela Schaepman‐Strub, Niels M. Schmidt, Franziska Schrodt, Sofie Sjögersten, Manuel J. Steinbauer, Lærke Stewart, Beate Strandberg, Anne Tolvanen, Craig E. Tweedie, Mark Vellend
Wildland Resources Faculty Publications
The Arctic is warming four times faster than the global average1 and plant communities are responding through shifts in species abundance, composition and distribution2,3,4. However, the direction and magnitude of local changes in plant diversity in the Arctic have not been quantified. Using a compilation of 42,234 records of 490 vascular plant species from 2,174 plots across the Arctic, here we quantified temporal changes in species richness and composition through repeat surveys between 1981 and 2022. We also identified the geographical, climatic and biotic drivers behind these changes. We found greater species richness …
Different Effects Between Trigeminal Sensory And Vagal Visceral Input On Salivary Gland Blood Flow, Ratna Ramadhani, Toshiya Sato, Hisayoshi Ishii
Different Effects Between Trigeminal Sensory And Vagal Visceral Input On Salivary Gland Blood Flow, Ratna Ramadhani, Toshiya Sato, Hisayoshi Ishii
Journal of Dentistry Indonesia
Objective: The purpose of the present study was to evaluate the different effects of trigeminal sensory and vagal-visceral inputs on blood flow (BF) in the submandibular gland (SMG). Methods: Ten to eleven-week-old Wistar rats were anesthetized with urethane (1.0 g/kg) and artificially ventilated. The femoral artery was cannulated for systemic arterial blood pressure (SABP) measurement. The cervical sympathetic trunk (CST) on both sides and the cervical vagus nerve (CVN) on the right side were cut before the stimulation of the left abdominal vagus nerve (AVN). The CVN and lingual nerve (LN) were stimulated after cutting the CST and CVN. AVN, …
Bilateral Germ Cell Tumor Of The Testis: Biological And Clinical Implications For A Stem Versus Genetic Origin Of Cancers, Jamaal C Jackson, Darren Sanchez, Aron Y Joon, Marcos R Estecio, Andrew C Johns, Amishi Y Shah, Matthew Campbell, John F Ward, Louis L Pisters, Charles C Guo, Miao Zhang, Niki M Zacharias, Shi-Ming Tu
Bilateral Germ Cell Tumor Of The Testis: Biological And Clinical Implications For A Stem Versus Genetic Origin Of Cancers, Jamaal C Jackson, Darren Sanchez, Aron Y Joon, Marcos R Estecio, Andrew C Johns, Amishi Y Shah, Matthew Campbell, John F Ward, Louis L Pisters, Charles C Guo, Miao Zhang, Niki M Zacharias, Shi-Ming Tu
Faculty, Staff and Student Publications
Germ cell tumors of the testis (GCTs) provide an ideal tumor model to investigate the cellular versus genetic origin of cancers. In this single institutional study, we evaluated 38 patients with bilateral GCT, including tumors that occurred simultaneously (synchronous) and those occurring at different times (metachronous). For nine of these patients, DNA was isolated from the right and left GCT to determine the genomic and epigenetic differences between tissues using whole-exome sequencing (WES) and reduced representation bisulfite sequencing (RRBS). We found that seminomas and non-seminomas are molecularly distinct based on DNA methylation and not due to synchronous or metachronous disease. …
The Effects Of Prescribed Medications On Depressive Symptoms And Neurocognitive Performance In People With Hiv, Asante R Kamkwalala, Avery Matthews, Ankita Garg, Upal Roy, Qing Ma, Maile Karris, Erin Sundermann, Ronald J Ellis, Patricia K Riggs, Mattia Trunfio, Jennifer Blanchard, David J Moore, Leah H Rubin, Scott L Letendre
The Effects Of Prescribed Medications On Depressive Symptoms And Neurocognitive Performance In People With Hiv, Asante R Kamkwalala, Avery Matthews, Ankita Garg, Upal Roy, Qing Ma, Maile Karris, Erin Sundermann, Ronald J Ellis, Patricia K Riggs, Mattia Trunfio, Jennifer Blanchard, David J Moore, Leah H Rubin, Scott L Letendre
Faculty, Staff and Student Publications
Background: Alterations in brain function and structure, such as depression and neurocognitive impairment, continue to occur in people with human immunodeficiency virus (HIV, PWH) taking suppressive antiretroviral therapy (ART). The lifespan of PWH has improved but the healthspan remains worse than people without HIV, in part because of aging-related diseases. As a result, polypharmacy is common and increases the risk of drug-drug interactions and adverse reactions.
Methods: This cross-sectional project investigated the relationship between 7 medication-related metrics (including anticholinergic burden), depressive symptoms, and neurocognitive performance in 491 PWH at a single center in the United States. All participants were taking …
Distribution Of Mussels In Two Intermittent Upland Streams Of The Arkansas Valley Ecoregion, Aaron A. Brady, Seth Drake, Zach Crain, Kendall Moles
Distribution Of Mussels In Two Intermittent Upland Streams Of The Arkansas Valley Ecoregion, Aaron A. Brady, Seth Drake, Zach Crain, Kendall Moles
ATU Scholars Symposium
Freshwater mussels are facing an increasing need for conservation due to their declining populations. More data is needed on mussel distributions, especially in tributaries of large rivers to properly conserve and restore populations. Big Shoal Creek and Little Shoal Creek are two upland-tributaries of the Arkansas River (Lake Dardanelle) in which no records exist for freshwater mussel populations. We addressed this knowledge gap by sampling a total of 9 sites in Little Shoal Creek and 18 sites in Big Shoal Creek to determine the abundance and distribution of mussels in these streams. Mussels were sampled using a timed search approach. …
Gathering A Population Assessment Of Endemic Ozark Longear Sunfish (Lepomis Sp. Ozark) In The Illinois Bayou Watershed, Kade Zeiner
ATU Scholars Symposium
The Ozark Longear Sunfish (Lepomis sp. Ozark) is a species endemic to the Ozark Highlands and Boston Mountains, primarily found in headwater streams that dry up in the summer. Their spawning period occurs from May to August, and because of the impact dry seasons have on water level in headwater streams, there's a possibility their population and health may be impacted. As an endemic species, they play a key role in their ecosystem, and their unique position makes them significant for both ecological and recreational reasons. Because of the wide variety of Sunfish species the state offers, new recreational challenges …
Bibliometric Analysis Of Research Trends Related To Human Immunodeficiency Virus., Madyson E. Johnson, Kaitlyn R. Coffman, Valerie Rivas, Elizabeth Barrett
Bibliometric Analysis Of Research Trends Related To Human Immunodeficiency Virus., Madyson E. Johnson, Kaitlyn R. Coffman, Valerie Rivas, Elizabeth Barrett
ATU Scholars Symposium
Human immunodeficiency virus poses major health burden across the globe including the United States of America and has its zoonotic origin from the Simian Immunodeficiency viruses of sooty mangabey monkey and chimpanzee in Africa. Epidemiological trends indicate that even though the mortality rates for HIV are falling globally, the rates of new cases have been rising since 2010 in several countries including the USA. An estimated 0.5% of the human population is currently infected with the virus with countries like USA, India, Nigeria and South Africa carrying the highest burden of the disease. Host receptors such as CD4 and coreceptors …
Discovering And Characterizing Novel Temperate Bacteriophage Infecting Arthrobacter Globiformis B-2979, Paige M. Baldwin, Michael Bennet, Evangelia A. Buonamici, Hanan E. Isik, Niran E. Isik, Vienna Li, Mia R. Mazakas, Aaryan M. Modi, Nikita Muppoor, Kylie A. Oliver, Vidhi M. Patel, Kylie Tabak, Jamie K. Yu, Laura Weber
Discovering And Characterizing Novel Temperate Bacteriophage Infecting Arthrobacter Globiformis B-2979, Paige M. Baldwin, Michael Bennet, Evangelia A. Buonamici, Hanan E. Isik, Niran E. Isik, Vienna Li, Mia R. Mazakas, Aaryan M. Modi, Nikita Muppoor, Kylie A. Oliver, Vidhi M. Patel, Kylie Tabak, Jamie K. Yu, Laura Weber
STEM Student Research Symposium Posters
AmiCi24 is a novel temperate bacteriophage collected from a soil sample originating in Sewell, NJ, USA and cultivated with Arthrobacter globiformis B-2979. AmiCi24 is a Siphoviridae morphotype, belonging to the cluster AS and subcluster of AS3. The AmiCi24 genome consists of 38,466 basepairs, encoding 68 genes.
Influence Of Biting Flies On The Growth And Condition Of Nestling Eastern Bluebirds, Ella Grace Bollinger
Influence Of Biting Flies On The Growth And Condition Of Nestling Eastern Bluebirds, Ella Grace Bollinger
ATU Scholars Symposium
Habitat alteration and climate change are expected to increase the range, abundance, and season length of ectoparasites and the pathogens they carry. This is particularly concerning for nestling birds that are relatively naked and immobile, making them vulnerable to attacks by biting flies such as blackflies and mosquitoes. Despite the ubiquity of biting flies and the challenges they pose to nestlings, studies investigating their association with breeding birds remain rare. To address this, we propose a series of observational and experimental field studies with Eastern Bluebirds (Sialia sialis) to investigate the attraction of biting flies to active nests …
Investigating Silicon As A Candidate For Plant Synthetic Biology, Stephanie N. Nelms, Kai Herring, Luke Hanke, William Foley
Investigating Silicon As A Candidate For Plant Synthetic Biology, Stephanie N. Nelms, Kai Herring, Luke Hanke, William Foley
ATU Scholars Symposium
The physicochemical properties of silicon are closely related to carbon. Certain species of plants accumulate high amount of silicon, however, their physiological role and molecular mechanism of sequestration and distribution in plant tissues are poorly understood. The bonding potential of silicon is analogous to carbon and silicon is a key element propelling nanotechnology and digital revolution. Recent discoveries of silicon in Mars and the Moon along with metabolic engineering of enzymes that can incorporate and cleave silicon from organic compounds have consolidated the idea of silicon-based synthetic cellular lifeforms. Bibliometric analysis was used to evaluate the trend of research in …
Using Guano To Determine Ozark Big-Eared Bat Cave Occupancy In Arkansas, Lark E. Sybrant
Using Guano To Determine Ozark Big-Eared Bat Cave Occupancy In Arkansas, Lark E. Sybrant
ATU Scholars Symposium
The Ozark big-eared bat (Corynorhinus townsendii ingens) is endangered in Arkansas and is known to have small populations, range restrictions, and specific habitat requirements in the Ozark-St. Francis National Forest. Beyond their known range, there are other potentially suitable areas that have not been confirmed. We aim to test whether the non-invasive genetic analysis of guano samples can identify Ozark big-eared bat cave use and expand their known range. Additional locations need to be surveyed to ensure site protection, as unknown caves are susceptible to human disturbance and damage. Twenty-five sites were surveyed at the southeastern extent of their known …
Using Environmental Dna To Evaluate The Distribution And Abundance Of Western Chicken Turtles, Kai D. Scarangella
Using Environmental Dna To Evaluate The Distribution And Abundance Of Western Chicken Turtles, Kai D. Scarangella
ATU Scholars Symposium
The Western Chicken Turtle (Deirochelys reticularia miaria; WCT) is a Species of Greatest Conservation Need that is currently under review for federal listing and is assumed to be rare and declining across its range. WCT are threatened by a variety of anthropogenic challenges, including habitat loss, habitat modification, and road mortality. The conservation of this species is further hindered by a lack of understanding of its distribution, abundance, and population trends. These knowledge gaps arise largely from the species’ unique characteristics and cryptic nature. More specifically, WCT demonstrate prolonged aestivation and are notoriously difficult to capture. Environmental DNA …
Cellular And Molecular Mechanism Of Heavy Metal Phytoremediation, Kaitlin A. Edwards, Kayle Dacus, Autumn Wilbanks, Tatum Simms
Cellular And Molecular Mechanism Of Heavy Metal Phytoremediation, Kaitlin A. Edwards, Kayle Dacus, Autumn Wilbanks, Tatum Simms
ATU Scholars Symposium
Rapid urbanization and industrial activities have contributed to heavy metal contamination of several habitats thus leading to an emerging health and environmental challenge. Some heavy metals such as zinc, iron, molybdenum, manganese, copper, cobalt and nickel are found in trace amounts in biological organisms, however, most are harmful for cellular metabolism. Certain species of plants can accumulate large amounts of heavy metals and has been utilized to sustainably clean contaminated soil and water by a process called phytoremediation. Recent lab and field studies have reported promising results that could propel commercialization of this technology. The cellular and molecular mechanism involved …