Digital Commons Network^™

Involvement Of The Mpfc In Narcissism And Celebrity: A Transcranial Magnetic Stimulation Study, Sydney Ash

Theses, Dissertations and Culminating Projects

Narcissism is typically characterized by extreme self-focus, lack of empathy for others, and emotional regulation deficits. Grandiose narcissism has been linked to an increased desire for fame, while vulnerable narcissism has been linked to an increase in celebrity worship. While there is a lack of research concerning the neural correlates of desire for fame and celebrity worship, narcissism has been correlated with the medial prefrontal cortex (mPFC) in various studies. The current study aimed to identify relationships between grandiose and vulnerable narcissism, fame appeal, celebrity attitudes, need to belong, and self-esteem using six scales. We also targeted the mPFC with …

Differential Regulation Of The Prkacaa Promoter In Zebrafish Melanoma Cell Lines, Maria Fiuk

Theses, Dissertations and Culminating Projects

The Inducible cAMP Early Repressor (ICER) comprises a group of isoforms that function as transcription factors within the cyclic AMP (cAMP) signaling pathway. These isoforms are encoded by the cAMP Response Element Modulator (CREM) gene. The cAMP signaling pathway and its associated transcriptional regulators have been implicated in the development of resistance to BRAF/MEK-targeted therapies in melanoma. Recent findings from our laboratory demonstrated that transgenic ICER expression in a zebrafish melanoma model promotes the formation of aggressive melanomas. Cell lines were established from tumors expressing ICER, as well as from control tumors expressing Green Fluorescent Protein (GFP). To begin characterizing …

A Tale Of Two Asters: Resolving The Plant And Microbial Community Structure Of An Invasive And Native Forb, William Cartelli

Theses, Dissertations and Culminating Projects

Old fields dominated by flowering forbs are frequent targets for ecological restoration, particularly because they are often inhabited by invasive species whose ecological effects remain context dependent and widely debated. While native plants are typically favored in restoration efforts, and invasive species viewed as threats to biodiversity, such classifications may oversimplify ecological function. This study investigates two dominant genera of the Asteraceae family —Centaurea stoebe (L) (non-native) and Solidago spp. (S. rugosa and S. canadensis, both native)—to examine whether biogeographic origin or ecological strategy more strongly influences their impact on above and below ground community structure. Despite their contrasting origins, …

Improving Brain Health: Exercise As A Tool For Enhancing Executive Function And Reducing Stress In Older African Americans, Destiny Ellise Ramos

Theses, Dissertations and Culminating Projects

Older African American (AA) adults face disproportionately higher risk of stress and Alzheimer's Disease and Related Dementias (ADRD) compared to other racial and ethnic groups, yet they remain underrepresented in intervention-based research. Previous research has suggested aerobic exercise may reduce stress and benefit executive functioning, which is among the first cognitive domains to be affected in ADRD; however, no studies to date have directly tested the impact of aerobic vs. non-aerobic exercise in older AAs at high risk for developing ADRD. The current study evaluated the effects of a group-based cardio dance fitness (CDF) exercise intervention versus a strength, flexibility, …

Reevaluating The Role Of Ruppia Maritima: Recruitment Dynamics And Habitat Use By Blue Crabs (Callinectes Sapidus) And Associated Benthic Fauna In A Mid-Atlantic Seagrass Community, Delaney St. Pierre

Theses, Dissertations and Culminating Projects

The value of seagrasses as essential fish habitat is well recognized, but limited data exist on the value of one particular species, Ruppia maritima (widgeon grass), as habitat for fish and invertebrates. During the summer of 2024, I evaluated R. maritima, Zostera marina (eelgrass) and mixed beds to assess their relative value as habitat in Barnegat Bay, New Jersey. Results from throw traps indicated significant monthly differences for pipefish, gobies, blue crabs, grass shrimp, and sand shrimp, driven by active recruitment events. When evaluating habitat type, we found no taxa that were significantly more abundant in Z. marina habitat as …

Neuronal Tol-1 Integrates Microbial And Metabolic Cues To Modulate Feeding And Aversion In C. Elegans, Gursimran Singh Gujral

Theses, Dissertations and Culminating Projects

Toll-like receptors (TLRs) are key mediators of innate immunity, but emerging evidence suggests that they also play critical roles in the functioning of the central nervous system. This thesis explores the function of TOL-1, the Caenorhabditis elegans homolog of mammalian TLRs, in sensory neurobiology and behavioral responses to nutritive food. In particular, carbon dioxide and ethanol are commonly encountered in microbial environments and can signal metabolically active food sources or potential pathogens. Using tol-1 loss-of-function mutants, neuronal rescue lines, and a combination of molecular, tissue imaging, and behavioral assays, we demonstrate that TOL-1 functions in chemosensory neurons to regulate feeding …

Neuro-Immune Regulation Of Feeding Behavior And Alcohol Intoxication In Caenorhabditis Elegans, Kamya Kiranbhai Shah

Theses, Dissertations and Culminating Projects

Alcohol use disorder (AUD) and obesity are major public health concerns, contributing to more than 28 million deaths annually. Despite extensive research, the mechanisms underlying excessive alcohol and food consumption remain incompletely understood. Emerging evidence suggests that neuro-immune crosstalk plays a pivotal role in feeding and alcohol-induced behaviors, with inflammation as a key pathological hallmark. Toll-like receptors (TLRs), traditionally recognized for their role in innate immunity, have recently been implicated in modulating neural responses to ethanol. However, the mechanisms of how TLR signaling influences feeding and alcohol-related behaviors remain largely unknown. To address this gap, we leveraged Caenorhabditis elegans (C. …

Exploring The Role Of The Id2 And Rab11fip3 Pathway In X-Linked Chronic Granulomatous Disease (Xcgd) Through Comparative Gene Expression Analysis, Kaili Coenen

Honors Theses

X-linked chronic granulomatous disease (XCGD) is a debilitating immunodeficiency disorder primarily affecting men. The disease results from mutations in the CYBB gene on the X chromosome, which encodes the GP91^PHOX protein responsible for electron transfer from NADPH to molecular oxygen. Despite the identification of the CYBB mutation, the pathological mechanism underlying the reduction in reactive oxygen species (ROS) generation in XCGD remains unclear. We hypothesized that comparative gene expression analysis, combined with pathway analysis, could identify genes and signaling pathways contributing to reduced reactive oxygen species (ROS) levels in XCGD. In this study, we analyzed gene expression data from four …

Exploring The Role Of Lysine Acetylation During Biofilm Formation In Bacillus Subtilis, Jennifer Nguyen, Briana Ericka Reid, Valerie Carabetta

Rowan-Virtua Research Day

Biofilms are structured communities of bacterial cells encased in a self-produced extracellular matrix, composed of polysaccharides, extracellular DNA, and proteins. Bacteria in a biofilm pose significant challenges in healthcare due to their resistance to disinfectants and tolerance to antibiotics. In some species, histone-like proteins were found to be important structural components of the biofilm. Nε-Lysine acetylation is a widespread post-translational modification (PTM) in bacteria, which can alter a protein’s function. The histone-like protein HBsu in Bacillus subtilis is acetylated at seven sites in vivo. We hypothesized that the acetylation state of HBsu may alter biofilm structure or the genetic programming, …

Dabigatran Reduced Acute Microgliosis In A Mouse Model With Tbi, Nicholas R. Eltman, Rashmeena Abbasi, Mary C. Kosciuk, Syed Ahmed, Jose L. Pascual, Randel L. Swanson, Nimish K. Acharya

Rowan-Virtua Research Day

Objective:

The study objective was to investigate the acute anti-inflammatory effects of dabigatran in a preclinical mouse controlled cortical impact (CCI) model of severe traumatic brain injury (TBI).

Design

Mice were separated into three groups: controlled cortical impact (CCI) with dabigatran (drug treatment, n=5), CCI with saline (positive control, n=5), and sham CCI without saline or dabigatran (negative control, n=3). Dabigatran (80mg/kg) or saline was administered orally at 2, 10, 18, 26, 34, and 42 hours following experimental CCI in the drug treatment or positive control groups, respectively. Animals in the negative control group received sham CCI only. 48h following …

Exploring Intracellular Signaling Responses To Ks18, A Potent Mcl-1 Inhibitor, In Multiple Myeloma, Emily Nelson, Omar S Al-Odat, Dhruti A. Brahmbhatt, Tulin Budak-Alpdogan, Subash Jonnalagadda, Manoj Kumar Pandey

Rowan-Virtua Research Day

Multiple myeloma (MM), a cancer of plasma B cells, is a hematological malignancy in which patients inevitably relapse and develop drug resistance. Mcl-1, a member of the anti-apoptotic subgroup of Bcl-2 family proteins, plays a critical role in the progression of multiple myeloma and contributes significantly to drug resistance. Elevated Mcl-1 expression is observed in approximately 52% of MM patients at diagnosis, increasing to 81% at relapse. Given its driving role in disease progression and therapy resistance, Mcl-1 inhibition has emerged as a promising therapeutic target, prompting ongoing research into the development and clinical evaluation of Mcl-1 inhibitors, particularly for …

Accelerated Tumor Growth And Lymphatic Spread Of Transplantable Melanomas In Tumor Necrosis Factor(Tnf)-Transgenic Mice, Catherine F. Alapatt, Robert Hughes, Roger Sheffmaker, Gillian Mcguire, Daniel Deegan, Igor Kuzin, Andrea Bottaro

Rowan-Virtua Research Day

Melanoma is the fifth most common cancer among American adults, with significant morbidity and mortality at 5 years remaining >60% for patients with stage IV disease. The malignancy is due to the transformation of melanocytes, with one of the major risk factors being ultraviolet light exposure. Although as many as one in five human cancers have been linked to chronic inflammation, the role of inflammatory signals in melanoma growth and metastasis remains poorly understood.

Tumor necrosis factor (TNF)-transgenic (TNFtg) mice are a well-established model of chronic systemic inflammation, with involvement of joints and other organ systems. To assess the effect …

Grains, Seeds & Hay Industry Funding Scheme: 2023-24 Annual Report, Department Of Primary Industries And Regional Development, Western Australia

Biosecurity published reports

The Grains IFS collects funds from producers to address biosecurity pest and disease threats relevant to and determined by the WA grains/seed/hay industry. The current IFS contribution rate of 0.25 cents per tonne of grain and seed, and 0.125 cents per tonne of hay, is applied to the first sale of produce grown in the agricultural areas of WA in 2023-24. Grains IFS contributions fund the:

1. Skeleton Weed Control Program (SKW).

2. Three Horned Bedstraw Eradication Program.

3. Research and Development (R&D) – Research grants and programs to improve the effectiveness and/ or efficiency of the IFS-funded programs, as …

Nebline, May 2025

NEBLINE Newsletter Archive from Nebraska Extension in Lancaster County

NEBLINE, May 2025

Tips on Staying Cool During the Heat of a Temper Tantrum

What’s Your BBQ IQ?

May Recipe of the Month — Air Fryer Teriyaki Beef Kabobs

Insect and Disease Control for Organic Vegetable Gardeners

May Garden Guide

Cash Rent Survey

No Matter Where You Live, Submit a Request Before You Dig!

Battling Scales in the Landscape

Three Lancaster County 4-H’ers Modeled Their Sewn Garments at Omaha Fashion Week

Ignite by 4-H 2025 National Conference

May Heart of 4-H Volunteer Award — Dayle Williamson

2024 National Index Study of 4-H Youth

Clover College, June 10–13; Registration Opens in …

Nutrition, Sleep, And Training Habits Enhance Endurance Race Performance, Anna F. Breed

Honors Theses

In recent years, marathon and ultra-marathon participation has grown substantially. Past research has shown that a range of variables influence the performance of endurance athletes. This study included participants of the Forgotten Florida 50-mile and 100-mile race and the Chattanooga Erlanger Half-Marathon and Marathon. These athletes were questioned about their sleep, nutrition, and training habits implemented for the races they completed. The results show the significance of carbohydrate consumption throughout the race for energy maintenance and shortened race times. Also, it was found that hill repeats and tempo runs brought about more successful race times for the runners who implemented …

Arthroscopy And The Future Of Surgery: Personal And Public Health Benefits, Preston T. Koski

Honors Thesis

Arthroscopy focuses on operating on the body using probes and working through keyhole incisions on the skin. This rapidly evolving field has seen many innovations in its technology, aided by advances in optical and surgical capabilities. Moreover, it presents many advantages over traditional surgery that directly impact the patient. Shorter recovery time and lessened scarring, reduced postoperative pain and opioid dependence, and less risk of infection are key benefits over open surgery. These benefits can also be applied to areas of public health. Minimizing the burden on hospital resources, reducing the environmental impact of surgery, and improving cost-effectiveness in healthcare …

Role Of Evolutionarily Conserved G4 Structures In Enhancer-Promotor Interactions, Shahem Alqudah

Honors Theses

Gene regulation is governed by complex networks of interactions between enhancers and promoters, regions of the genome that are typically distant from one another yet functionally linked through chromatin looping. Recent research has revealed the significant role of Gquadruplexes (G4s) in facilitating these interactions. This thesis explores the role of long Gquadruplex regions (LG4s) in enhancer–promoter communication, proposing that these regions mediate physical interactions between enhancers and their target promoters through direct G4:G4 interactions. Using a chromatin conformation capture (EQuIP-seq), electrophoretic mobility shift assays (EMSA), and luciferase reporter assays, the study demonstrates that LG4s may drive gene expression by promoting …

Advancement Of Wrongful Conviction Prevention Strategies In Forensic Science, Isabella Pinto

Honors Projects

The National Registry of Exonerations (NRE) has identified 1,051 of its logged cases to involve forensic evidence in some way, nearly one-third of the total 3,600 exonerations in its database. Analysis of the NRE and Innocence Project databases revealed the most common factors in forensic-related wrongful convictions: expert testimony, flawed methodologies (most of which are no longer in use), and statistical misinterpretations of results. The majority of scholars agree that oversight in forensic casework must be improved in order to meaningfully resolve issues. Creation of commissions in each state would address all of the identified errors, though not a catch-all …

Soil-Based Emissions And Context-Specific Climate Change Planning To Support The United Nations (Un) Sustainable Development Goal (Sdg) On Climate Action: A Case Study Of Georgia (Usa), Davis G. Nelson

All Theses

Soil-based emissions from land conversions are often overlooked in climate planning. The objectives of this study were to use quantitative data on soil-based greenhouse gas (GHG) emissions for the state of Georgia (GA) (USA) to examine context-specific (temporal, biophysical, economic, and social) climate planning and legal options to deal with these emissions. Currently, 30% of the land in GA has experienced anthropogenic land degradation (LD) primarily due to agriculture (64%). All seven soil orders were subject to various degrees of anthropogenic LD. Increases in overall LD between 2001 and 2021 indicate a lack of land degradation neutrality (LDN) in GA. …

Antiproliferative Effects Of Salvia On Breast Cancers., Allison C. Portaro

College of Arts & Sciences Senior Theses

Breast cancer is the most common cancer diagnosed in female adults, with 2.3 million new cases worldwide in 2020. Plants have been used in traditional medicine and are a potential source of pharmaceuticals. One example is the large Lamiaceae (mint) family. The Salvia genus, commonly known as the sages, is the largest genus in Lamiaceae with almost 900 known species. Salvia lyrata (lyre-leaved sage) has a history of Native American medicinal use to treat cancers and other ailments resulting in this plant being referred to as ‘cancer weed.’ Extracts were produced from the leaves of S. lyrata, S. lyrata …

The Effects Of Prenatal Cigarette Smoke Exposure On Developmental Milestones, Megan Jacobs

College of Arts & Sciences Senior Theses

In Kentucky, a reported 12.7% of mothers smoke cigarettes during pregnancy. Nicotine readily crosses the placental and blood-brain barriers, with fetal blood concentrations reaching 15% higher than maternal levels. By stimulating and desensitizing nicotinic acetylcholine receptors in the autonomic nervous system, nicotine disrupts uteroplacental blood flow, potentially altering fetal growth and development.

To investigate the effects of prenatal cigarette smoke exposure (CSE) on developmental milestones, C57Bl6 mice were exposed to either cigarette smoke (CSE, n = 30) or filtered room air (Sham, n = 20) for 3 hours daily from two days before mating until the day before birth. Offspring …

The Impact Of Acute Beetroot Juice Supplementation On Resting Cardiovascular Responses In Young Women, Manuel Munoz Ii, Robert L. Herron

Undergraduate Research (Journal)

Research has shown that acute supplementation with dietary nitrate will increase the amount of circulating nitrate, boosting NO bioavailability via the nitrate-nitrite-NO pathway, providing enhanced vasodilation. There are limited dietary nitrate studies including young, healthy female participants. The purpose of this study was to investigate the influence of acute dietary nitrate, via beet root juice (BRJ) supplementation, on resting heart rate and blood pressure in young, healthy women. A total of 11 women (aged 18-22) performed a repeated-measures, placebo-controlled, counter-balanced, crossover design investigated the impact of dietary nitrate on the cardiovascular system’s resting measurements after one hour. All participants completed …

Firefighters' Perceived Effectiveness Of Peer Support For Job-Related Stressors, Camryn M. Travis

Senior Honors Projects

Firefighters experience immense job-related stress. Firefighters can respond to hundreds of traumatic calls or critical incidents throughout their careers. Witnessing a critical incident can be highly stressful and mentally taxing. Therefore, some fire departments offer mental health resources such as Critical Incident Stress Management/Debriefing (CISM/D) and Peer-group support to help firefighters cope with stressful incidents. Additionally, firefighters may seek professional mental health treatment. To investigate firefighters’ perceptions regarding the effectiveness of these resources, an anonymous survey of Rhode Island firefighters was conducted. The sample included 51 firefighters (n = 51), was mostly male (90.2%), and self-identified as predominantly white (94.1%) …

Exploring Mimicry And Visual Communication In Woodpeckers: A Field Study Utilizing 3d-Printed Models, Lauren M. Smith

Biology Theses

The evolution of similar phenotypes poses an interesting challenge in evolutionary biology. While divergent ecologies may drive differing morphology, physiology, or behavior, similar phenotypes are often due to similar ecology or selection for mimicry. One prominent case of mimetic phenotypes is found in hairy and downy woodpeckers. While several hypotheses might explain the hairy-downy mimicry complex, I aimed to assess the idea that downy woodpeckers benefit from resembling hairy woodpeckers. To test this hypothesis, I used 3D-printed models of various woodpecker species in the field. These models were painted with colors that resemble woodpecker species. The experimental conditions were 3D …

Pollination Synchrony Along A Great Lakes Thermal Gradient, Joe Armstrong

Biology Theses

Pollination is an essential mutualistic interaction between plants and animals. Often agricultural crops rely on successful pollination to provide profitable and nutrient rich harvests. Successful pollination requires synchrony between flowers and pollinators. Western New York with its proximity to the Great Lakes has benefited as a Climate refugia; however, recent climate change and increased temperature variation have threatened regional fruit crops. In this thesis, I explored the synchrony between native pollinators, non-native pollinators, and apple flowering along a coastal to inland gradient for farms in Niagara County. I measured temperature, evaluated apple flower phenology, and harvested pollinators during the Spring …

Mitigating Nitrogen Losses: The Role Of Enhanced Efficiency Fertilizers In Sustainable Corn Production, Dipesh Giri

Department of Agronomy and Horticulture: Dissertations, Theses, and Student Research

Nitrogen (N) is essential for crop production, but its inefficient use often leads to environmental losses through nitrate leaching, ammonia volatilization, and nitrous oxide (N₂O) emissions. Enhanced efficiency fertilizers (EEFs), such as nitrification inhibitors (NIs) and urease inhibitors (UIs), have been developed to minimize these losses and improve nitrogen use efficiency (NUE). This research combined a multi-year field experiment and a controlled laboratory study to evaluate how dual-inhibitor fertilizers compare to conventional urea and single-inhibitor formulations in Nebraska cropping systems. The main objective was to understand how nitrogen inhibitors influence N availability, crop performance, and nitrogen losses across different environmental …

Improving Nitrogen Management And Corn Productivity Through Enhanced Efficiency Fertilizer And Cover Crop Integration In Nebraska Cropping Systems, Madhusudhan Adhikari

Department of Agronomy and Horticulture: Dissertations, Theses, and Student Research

Effective nitrogen (N) management is vital for sustaining corn yield and reducing environmental impacts in Nebraska cropping systems. Three field studies were conducted to evaluate the impact of 1) fertilizer type (anhydrous ammonia [AA] with nitrification inhibitor: enhanced efficiency fertilizer [EEF] or AA without EEF) and N application timing (pre-plant vs. split with side-dress UAN) on in-season soil N availability, crop response, nitrous oxide (N₂O) emissions, residual soil N and N use efficiencies (NUEs); 2) winter cover crop (CC) species and crop rotation variability on CC biomass production, N uptake, soil N dynamics, and cash crop performance in …

Extending Cover Crop Growing Window To Improve The Health Of Environmentally Sensitive Soils, Noshin Ara Tunazzina

Department of Agronomy and Horticulture: Dissertations, Theses, and Student Research

Sloping and sandy soils are highly susceptible to degradation. The health of these soils could be improved with cover crops (CCs). However, CC effectiveness in improving soil health mainly depends on CC biomass production, which is often low in temperate regions. The question is: how can we increase CC biomass production? Lengthening the CC growing window can be a potential strategy. This study assessed how 1) interseeded and terminated early (2-3 weeks before crop planting) CC, 2) interseeded and terminated late (at crop planting) CC, 3) drilled (after harvest) and terminated early CC, 4) drilled and terminated late CC, and …

Characterizing Xylella Fastidiosa Pathogen Dynamics On Diverse Small Fruit Farms, Alexandra Ratay

All Theses

Global agriculture has been threatened for over a century due to the emergence of the plant pathogenic bacteria Xylella fastidiosa (Lysobacterales: Lysobacteraceae) (Xf). Xf comprises five main subspecies and induces severe physiological symptoms in a diverse set of host plant species by limiting xylem function. Xylem-feeding insect vectors can transmit Xf to host plants, spreading disease and reducing fruit yield. Here I studied Xf prevalence on small fruit farms to determine Xf host plant and vector infective status to the Xf subspecies level. I detected Xf in 28 host plants in South Carolina containing either Xf subspecies fastidiosa …

Don’T Be A Big Baby: Phenotypic Novelty In The Facultative Paedomorph Ambystoma Talpoideum., Andrew S. Kanes

All Theses

This thesis explores the relationship between heterokairy and the skin microbiota of amphibians, specifically focusing on the facultatively paedomorphic salamander, Ambystoma talpoideum. Heterokairy refers to variations in developmental timing that generate phenotypic novelty within life stages. The first chapter investigates how reordering metamorphosis relative to sexual maturation affects the skin microbiota in this species. By sampling different life stages—larval, paedomorphic, and metamorphic—results show the emergence of novel microbial combinations, resulting from both microbial gain and loss in the heterokairic paedomorphic stage. These findings suggest that changes in microbial communities may lead to phenotypic novelty and have broader eco-evolutionary implications. …