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Arkansas Corn And Grain Sorghum Research Studies 2024, Jason Kelley, Travis Faske Jun 2025

Arkansas Corn And Grain Sorghum Research Studies 2024, Jason Kelley, Travis Faske

Arkansas Agricultural Experiment Station Research Series

The 2024 edition of the Arkansas Corn and Grain Sorghum Research Studies Series includes research results on topics pertaining to corn and grain sorghum production, including weed, disease, nematode, and insect management; economics; irrigation; agronomics; soil fertility; drone use; and research verification program results.

Our objective is to capture and broadly distribute the results of research projects funded by the Arkansas Corn and Grain Sorghum Board. The intended audience includes producers and their advisors, current investigators, and future researchers. The Series serves as a citable archive of research results.

The reports inform and guide our long-term recommendations, but should not …


Basal Autophagy Promotes Accurate Chromosome Segregation In Drosophila Oocytes And Declines During Oocyte Aging, Diana C. Hilpert Jun 2025

Basal Autophagy Promotes Accurate Chromosome Segregation In Drosophila Oocytes And Declines During Oocyte Aging, Diana C. Hilpert

Dartmouth College Ph.D Dissertations

The frequency of trisomic pregnancies exponentially increases with advanced maternal age, a phenomenon known as the maternal age effect. The majority of these aneuploid pregnancies arise from meiotic segregation errors in the oocyte and premature loss of sister chromatid cohesion is a contributing factor. However, the mechanisms that lead to premature cohesion loss during oocyte aging are not fully understood.

Using Drosophila melanogaster as a model organism, work described in this dissertation demonstrates that basal levels of autophagy, a degradation process for damaged organelles and protein aggregates, are required during meiotic prophase for arm cohesion maintenance and accurate meiotic segregation …


Belowground Biomass Shifts Along A Temperate Forest Edge, Lara Holbrook Roelofs Jun 2025

Belowground Biomass Shifts Along A Temperate Forest Edge, Lara Holbrook Roelofs

Dartmouth College Undergraduate Theses

Anthropogenic land use change and development has caused widespread global forest fragmentation, resulting in a greater proportion of forests at or near a forest edge. Temperate forests are the most fragmented forest biome, and forests in the Northeastern U.S. are particularly fragmented due to a history of intense land use and development pressure. Nearly a quarter of these forests are now within 30 meters of a forest edge. These edge ecosystems have distinct abiotic and biotic gradients that differentiate them from forest interiors, including increased light, temperature, and exposure to wind and other disturbances, as well as decreases in humidity …


Topodino: Self-Supervised Topological Representation Learning For Neuronal Morphologies, Yasser Binbisher Jun 2025

Topodino: Self-Supervised Topological Representation Learning For Neuronal Morphologies, Yasser Binbisher

Master's Theses

Neuronal cell types are categorized by transcriptomic identity, yet their morphological heterogeneity defies this classification. In response, researchers have adopted unsupervised graph representation learning as a tool to reveal morphological variation within single-class transcriptomic types. However, the complex geometry of neuronal morphology—especially long axons and dense dendrites—challenges graph neural networks, which struggle with message propagation across extended structures. To mitigate this, current approaches enforce sub-sampling on neuronal graphs and omit axons entirely, sacrificing critical biological features for computational efficiency. To overcome this trade-off, this thesis introduces TopoDINO, a self-supervised, topology-aware representation learning model designed to preserve the full hierarchical organization …


"The Effect Of Methylobacterium Symbioticum On The Growth And Yield Of Dent Corn And Romaine Lettuce", Sinead Carney Jun 2025

"The Effect Of Methylobacterium Symbioticum On The Growth And Yield Of Dent Corn And Romaine Lettuce", Sinead Carney

Master's Theses

Nitrogen (N) is an essential nutrient for plant growth and is often a limiting nutrient in cropping systems. An estimated half of applied N fertilizers are lost from cropping systems by processes that can be environmentally destructive, such as leaching and volatilization, and cause economic loss for growers. Effective N biofertilizers offer a means to mitigate the need for high inputs of synthetic N. The objectives of this study were to determine the effects of leaf inoculation with the N-fixing bacteria, Methylobacterium symbioticum, in combination with different rates of urea-N fertilizer on the physiology and yield of dent corn …


Stability Insights From Modeling Chronic Myelogenous Leukemia, Giovani Thai Jun 2025

Stability Insights From Modeling Chronic Myelogenous Leukemia, Giovani Thai

Master's Theses

This thesis centers around a model for chronic myelogenous leukemia (CML) as it behaves under imatinib treatment, a common medication for CML patients, and the anti-leukemia immune response. The dynamics are represented with a system of nonlinear delay-differential equations first constructed by Kim et al. in 2008, capturing population changes of T-cells and various CML growth stages. We investigate stability in both the clinical and mathematical sense. Through numerical simulations, we computationally incorporate a supplementary treatment plan to determine its effectiveness in aiding immune response and medication in achieving remission and full elimination. The primary goal is to conduct a …


State And Transition Models For Mulga Rangelands Of Western Australia, Alison O'Donnell, Anna E. Richards, Suzanne Prober, Peter-Jon A. Waddell, Sarah Luxton, Ian Watson, Brett Abbott, Philip Thomas, Joshua E. Foster Jun 2025

State And Transition Models For Mulga Rangelands Of Western Australia, Alison O'Donnell, Anna E. Richards, Suzanne Prober, Peter-Jon A. Waddell, Sarah Luxton, Ian Watson, Brett Abbott, Philip Thomas, Joshua E. Foster

Natural resources published reports

This report details a collaborative project between the Western Australian Department of Primary Industries and Regional Development and CSIRO that focused on developing State and Transition Models (STMs) for mulga rangelands in Western Australia. The overarching aim of the project was to improve the common understanding of the characteristics and dynamics of mulga rangeland ecosystems and the expected impacts of management. Specifically, the project aimed to collate expert knowledge and monitoring information using a nationally consistent framework to develop quantitative and dynamic STMs. The geographic scope of the project covers the extensive mulga rangelands of Western Australia, particularly the Gascoyne …


Neural Mechanisms Of Context-Sensitive Behavior In The Adult Male Zebra Finch, Katherine L. Anderson Jun 2025

Neural Mechanisms Of Context-Sensitive Behavior In The Adult Male Zebra Finch, Katherine L. Anderson

Dissertations, Theses, and Capstone Projects

Adapting behaviors to the perceived external environment is key to the success and survival of individuals in social species. This context-sensitive modulation of behavior is critical for informative interactions with conspecifics, like alerting a neighbor to a nearing predator or capturing the attention of a potential mate. For the adult male zebra finch (Taeniopygia guttata), a vocal-learning songbird, context-sensitive adaptions to a learned song are key for developing and maintaining pair-bonds with females who are extremely attentive to subtle modulations of song structure. In this thesis, I explore the hypothesis that the influence of a social behavior network …


The Sub-Syllabic Symphonies Of Self-Learning: How Do Zebra Finches Sing Them?, Abiesha Abiola Budiman Jun 2025

The Sub-Syllabic Symphonies Of Self-Learning: How Do Zebra Finches Sing Them?, Abiesha Abiola Budiman

Dissertations, Theses, and Capstone Projects

Learning is a lifelong journey, where the mind and muscle dance to a tune of memory and motion. It begins at infancy and continues throughout life, encompassing everything from singing to achieving peak performance in sports. Complex motor skills involve multiple components and require coordination of several muscles. Humans and animals are extremely adept at learning complex motor skills on their own. However, we do not completely understand how self-directed learning works. One group of animals used to observe self-directed learning are songbirds. Zebra finches, Taeniopygia guttata, are one of the most studied songbird species due to their well-defined …


The Ethnobotany And Pharmacology Of Medicinal Plants For Caribbean Women’S Health, Ella Thomas Vardeman Jun 2025

The Ethnobotany And Pharmacology Of Medicinal Plants For Caribbean Women’S Health, Ella Thomas Vardeman

Dissertations, Theses, and Capstone Projects

Approximately 55% of the world’s population lives in cities, and the United Nations estimates that this number will rise to 68% by 2050. Urban ethnobotany, the study of people’s traditional knowledge and use of plants in cities, is increasingly important as people adapt their cultural traditions to changing environments. In New York City (NYC), there have been several urban ethnobotany investigations in collaboration with Caribbean immigrant groups. However, there has yet to be an ethnobotanical survey that documents and botanically authenticates the medicinal plants used in the Haitian community. Previous collaborative research with women from the Caribbean in NYC has …


Elucidating The Roles Of Eukaryotic Initiation Factors Involved In Dap5 Mediated Translation, Jacob Nk Quartey Jun 2025

Elucidating The Roles Of Eukaryotic Initiation Factors Involved In Dap5 Mediated Translation, Jacob Nk Quartey

Dissertations, Theses, and Capstone Projects

Translation initiation in eukaryotes is a highly regulated process essential for accurate protein synthesis. It is a dynamic process that involves a complex interplay between messenger RNAs (mRNAs), ribosomal subunits, and a host of initiation factors, ensuring precise start codon selection and the subsequent assembly of the translation machinery. This process has well been known to be mediated by the eukaryotic Initiation Factor (eIF4F), which consists of the cap binding protein eIF4E, the scaffolding protein eIF4GI, and the helicase factor eIF4A.The recognition and binding of eIF4E to the m7G cap structure of the mRNA is essential for the …


Decoding The Plant Metabolome: A Metabolomics Approach To Guereza (Colobus Guereza) Feeding Ecology In Kibale National Park, Uganda, Emma Grace Thurau Jun 2025

Decoding The Plant Metabolome: A Metabolomics Approach To Guereza (Colobus Guereza) Feeding Ecology In Kibale National Park, Uganda, Emma Grace Thurau

Dissertations, Theses, and Capstone Projects

Plant metabolites, an elusive and diverse group of plant chemicals, represent a complex chemical interplay between plants and herbivores. Plants contain essential nutrients necessary for herbivore survival, yet herbivore consumption results in negative fitness consequences to a plant. This relationship has triggered a coevolutionary arms race in which plants have evolved chemical defenses to prevent herbivore consumption and herbivores, in response, have evolved their own counter-adaptations. This arms race has led to the diverse numbers of herbivores and plants observed today; therefore, these plant metabolites act as a signature of evolution through their influence on herbivore adaptations. Plant metabolites are …


Integrating High Throughput Phenotyping Approaches To Characterize Plant Traits And Support Nutrient Management Research, Katie J. Bathke Jun 2025

Integrating High Throughput Phenotyping Approaches To Characterize Plant Traits And Support Nutrient Management Research, Katie J. Bathke

Department of Agricultural and Biological Systems Engineering: Dissertations, Theses, and Student Research

Over the past decade, considerable research has addressed the social, economic, and agronomic challenges posed by imbalanced nutrient applications, particularly nitrogen and, more recently, sulfur. In response, high throughput plant phenotyping, as one of the latest approaches, has contributed to the development of innovative techniques for assessing key plant phenotypes under stress over time in both field and greenhouse environments. However, there is a limited number of studies applying these techniques for nutrient management, particularly in scenarios where two abiotic stressors coexist, such as the combination of water stress and nitrogen deficiency, or concurrent nitrogen and sulfur deficiencies.

In chapter …


Associations Between Vitamin D Deficiency And Sociodemographic Factors, Lifestyle Behaviors, And Metabolic Conditions: A Cross-Sectional Study From The Hnnhs In Greece, Asmae Mohamad Sadek Jun 2025

Associations Between Vitamin D Deficiency And Sociodemographic Factors, Lifestyle Behaviors, And Metabolic Conditions: A Cross-Sectional Study From The Hnnhs In Greece, Asmae Mohamad Sadek

Theses

Vitamin D deficiency (VDD) is a widespread global health concern associated with various sociodemographic, lifestyle, dietary, and metabolic factors. While previous studies examined VDD in Greece, few provided a comprehensive analysis across multiple determinants using representative national data. This study aimed to assess the prevalence and predictors of VDD among Greek adults and to examine its associations with sociodemographic, dietary, behavioral, and metabolic variables using data from the Hellenic National Nutrition and Health Survey (HNNHS). A cross-sectional analysis was conducted among 978 adults (≥19 years) from the HNNHS. Serum 25-hydroxyvitamin D [25(OH)D] concentrations < 20 ng/mL were defined as deficient and ≥20 ng/mL as normal. The median age of participants was 40.2 years, and 62.0% were female. The overall prevalence of VDD was 46.0%, with the highest rate observed among adults aged ≥60 years (62.2%). VDD was significantly associated with older age (p < 0.001), retirement status (62.9% among retired; p < 0.001), low and sedentary physical activity (32.7% and 32.6% vs. 50.8% among highly active; p < 0.001), higher HDL (median 52.0 vs. 49.0 mg/dL among VDD vs Normal; p = 0.001), elevated serum calcium (median 9.4 vs. 9.2 mg/dL among VDD vs Normal; p = 0.020), and lower insulin levels (median 7.5 vs. 8.0 μIU/mL among VDD vs Normal; p = 0.044). Dietary intake (total energy and macronutrients) and body composition were not significantly associated with VDD. In the multivariate model, significant independent predictors of VDD included being retired (AOR = 2.383; 95% CI: 1.596–3.558; p < 0.001), having higher serum calcium levels (AOR = 1.563; 95% CI: 1.078–2.266; p = 0.019), and higher HDL levels (AOR = 1.016; 95% CI: 1.005–1.027; p = 0.001). Physical activity level was also a key determinant; participants classified as sedentary or low active had significantly higher odds of deficiency compared to highly active individuals (AOR = 0.468; 95% CI: 0.319–0.690; p < 0.001). This counterintuitive result may be influenced by factors such as increased indoor physical activity, and warrants further investigation. Dietary intake and body composition were not significantly associated with VDD. The findings underscore the importance of incorporating sociodemographic and lifestyle factors into prevention strategies. Interventions should particularly focus on older adults, retired individuals, even if they have higher HDL and calcium levels, and are physically active.


West Coast Demersal Scalefish Resource Recovery Support Package: 2023-24 Report, Department Of Primary Industries And Regional Development, Western Australia Jun 2025

West Coast Demersal Scalefish Resource Recovery Support Package: 2023-24 Report, Department Of Primary Industries And Regional Development, Western Australia

Fisheries Published Reports

The West Coast Demersal Scalefish Resource (WCDSR) includes over 100 species in inshore (20–250 m deep) and offshore ( > 250 m) demersal habitats of the West Coast Bioregion. These species are caught by charter, commercial and recreational fishers.

The WCDSR is in recovery and managed under a 20-year recovery plan (2010–2030). DPIRD tracks recovery progress through scientific stock assessments of the indicator species (snapper, WA dhufish, and baldchin groper) every 3 years.

The 2021 WCDSR stock assessment showed limited recovery and additional management action was required.

In December 2022, the Minister for Fisheries announced commercial and recreational (including charter) sector …


Assessing Illegal Take Of Sea Turtle In Bocas Del Toro, Panamanian Caribbean, Daniela Carolina Rojas-Cañizales Jun 2025

Assessing Illegal Take Of Sea Turtle In Bocas Del Toro, Panamanian Caribbean, Daniela Carolina Rojas-Cañizales

Theses and Dissertations

In Bocas del Toro, Panama, sea turtles were exploited for generations to supply local, national, and international markets. Today, sea turtle species are globally protected by different laws, and Panama is no exception. However, the use of sea turtles in Bocas del Toro and local perceptions regarding the consumption of these reptiles are unknown. Accordingly, during May of 2024, I conducted twenty-five semi-structured interviews with key informants selected by targeted and snowball sampling. Sea turtle consumption persists, and there is a clandestine network to sell turtle meat and derived products in Bocas del Toro. This study provides the first assessment …


Digesting The Details: How Cooking Shapes The Microbiome And Influences Obesity, Tracy Lieu Jun 2025

Digesting The Details: How Cooking Shapes The Microbiome And Influences Obesity, Tracy Lieu

University Honors Theses

Obesity is a growing global health concern linked to chronic diseases and changes in the gut microbiome. While diet is known to affect gut microbes, less attention has been given to how food processing methods, such as heating, fermentation, and cold processing, change food in ways that influence the gut microbiome and health. This thesis reviews research on how different cooking and preparation techniques affect the availability of nutrients for microbial fermentation and the resulting effects on microbial diversity and metabolism. The findings show that fermentation and cold processing are the most supportive of gut health. These methods help preserve …


Woofs And Warbles: The Influence Of Urban Dog Walking On Birdsong, Grace Phillips Jun 2025

Woofs And Warbles: The Influence Of Urban Dog Walking On Birdsong, Grace Phillips

University Honors Theses

Recreational activity in natural areas can disrupt songbird singing during critical learning or courtship periods, increasing the risk of fitness and population declines in sensitive species. Local data on birdsong disturbance caused by recreation can guide management efforts protecting wildlife, such as signage, leash laws, and dog walking bans. This study assessed bird vocalization responses to groups with and without dogs in urban greenspaces. Surveys were conducted in Fall 2024 at three parks in Portland, Oregon, with varying rates of dog and human presence. Throughout two-hour observation periods, bird vocalization activity of seven songbirds was recorded at five-minute intervals and …


Evaluation Of Nature-Based Engineering Stream Restoration Of Plaster Creek Through Leisure Creek Condominium Association, Julie Wildschut, Rebecca Evenhouse, Andrea Lubberts, Dave Warners, Haley Weesies Jun 2025

Evaluation Of Nature-Based Engineering Stream Restoration Of Plaster Creek Through Leisure Creek Condominium Association, Julie Wildschut, Rebecca Evenhouse, Andrea Lubberts, Dave Warners, Haley Weesies

Faculty and Professional Research

When land that was once covered with vegetation and soil becomes dominated by impervious concrete and rooftops, the amount of water infiltrated by the ground plumets. As a result, most suburban areas contribute to the impairment of streams by adding excess water, nutrients, and pollutants to nearby waterways each time it rains. One harmful result of this is the erosion of stream banks. The rapid influx of water that occurs after rain events can destabilize and erode stream banks, resulting in excess sediment in the water. One location where this happened very prominently was a section of Plaster Creek which …


The Effects Of Sirulina And Nannochloropsis Supplementation On Broiler Performance, Intestinal Morphology, And Gut Microbiology, Emily Beckerman Jun 2025

The Effects Of Sirulina And Nannochloropsis Supplementation On Broiler Performance, Intestinal Morphology, And Gut Microbiology, Emily Beckerman

Master's Theses

The poultry industry is constantly searching for new nutritional strategies and better feed conversion ratio to enhance broiler growth and productivity. Microalgae have been shown to improve broiler performance and health depending on species and supplementation levels. The objective of this study was to determine the effects of Spirulina supplementation (Experiment I) and Nannochloropsis supplementation (Experiment II) on broiler production performance, intestinal morphology, and gut microbiology. In Experiment I, a total of 270 broiler chicks (one-day-old Ross 708) were obtained from a local hatchery after vaccinating against Newcastle, Marek’s disease, and Infectious Bronchitis. They were weighed and sorted into 18 …


Understanding The Habitat Associations Of Nearshore Rockfishes Inside And Outside Of Marine Protected Areas Using Hook-And-Line Data, Kaila Raeanne Fritch Jun 2025

Understanding The Habitat Associations Of Nearshore Rockfishes Inside And Outside Of Marine Protected Areas Using Hook-And-Line Data, Kaila Raeanne Fritch

Master's Theses

Habitat is an important driver in shaping the distribution of a range of species. For demersal fish species, benthic habitat characteristics can drive distribution and community structure. Understanding the relationship between habitat and species distribution in important, especially for exploited species such as rockfishes (Sebastes spp.). Increased data on the relationship between rockfish and benthic habitat characteristics could enhance marine protected areas (MPAs) and management practices which are used to protect rockfishes along the U.S. West Coast. To address this, we used hook-and-line, catch-and-release data that were collected inside two MPAs on the central coast of California, and …


Optimization Of Downy Mildew Management And Baby Kale Production On The Central Coast Of California, Emily M. Locke-Paddon Jun 2025

Optimization Of Downy Mildew Management And Baby Kale Production On The Central Coast Of California, Emily M. Locke-Paddon

Master's Theses

Baby kale (Brassica oleracea and other species) is a vital commodity as a salad green in spring mix and is widely produced on the Central Coast of California. Downy mildew, caused by Hyaloperonospora brassicae, is a devastating disease infecting economically important crops like cabbage, broccoli, cauliflower, horseradish, rapeseed, kohlrabi, Brussels sprouts, and kale. This foliar disease causes plant tissue to exhibit chlorotic and necrotic flecking and gray-white sporulation, affecting both the yield and quality of the crop and rendering the affected leaves unmarketable. The Central Coast’s cool climate and nighttime moisture, combined with dense plantings and sprinkler irrigation, …


Identifying Interchromosomal Interactions Using A Graph-Based Computational Pipeline, Ethan Outangoun Jun 2025

Identifying Interchromosomal Interactions Using A Graph-Based Computational Pipeline, Ethan Outangoun

Master's Theses

Current computational tools for analyzing chromatin organization are mainly focused on intrachromosomal interactions, despite growing evidence that suggests long-range interactions across chromosomes contribute to transcriptional regulation and disease development. This thesis aims to address this gap in interchromosomal genome analysis, presenting a robust computational pipeline that identifies a clique (i.e., a subgraph) of highly interacting trans-chromosomal regions anchored at a user-specified seed genomic locus. A weighted interaction network is constructed from an input Hi-C contact matrix, a widely used experimental assay for measuring genome-wide chromatin interactions. We model this input contact matrix as a graph and devise three different strategies …


The Effect Of Whole Fruits High In Anthocyanins On Markers Of Glycemic Control In Women, Sophia C. Johnson Jun 2025

The Effect Of Whole Fruits High In Anthocyanins On Markers Of Glycemic Control In Women, Sophia C. Johnson

Master's Theses

Cardiometabolic diseases are a significant health burden worldwide and remain the leading cause of death among adults in the United States. Type 2 diabetes mellitus (T2DM) is a central component of cardiometabolic dysfunction and substantially increases the risk for cardiovascular disease. As women enter the post-menopausal period, significant declines in estrogen levels lead to a heightened risk of T2DM in this population. Observational and experimental evidence has shown potential for fruits high in anthocyanins (ACs) to reduce the risk of T2DM and improve glycemic control. This systematic review and meta-analysis examined the current research on whole fruits high in ACs …


Subalpine And Alpine Plant Community Turnover In Yosemite National Park Following 30 Years Of Climate Warming, Rachel Friesen Jun 2025

Subalpine And Alpine Plant Community Turnover In Yosemite National Park Following 30 Years Of Climate Warming, Rachel Friesen

Master's Theses

Subalpine and alpine regions in California are warming more rapidly than lower elevations. In response, high-elevation plants may acclimate or adapt to the new climate, move to higher elevations or latitudes, persist in refugia, or go extinct. While models predict substantial declines in subalpine and alpine plant communities due to discontinuous population distributions and lack of upslope area, actual responses may vary due to lags in dispersal, establishment, and extinction. Although shifts in high-elevation plant communities have been documented in other regions of the world, such changes have not yet been studied in Yosemite National Park. To assess high-elevation plant …


Evaluating Nanobubble-Enriched Water Treatments For Cleaning Stainless Steel Winery Tanks At The Gallo Winery Research Station In Livingston, California, Edgar Godoy-Garcia Jun 2025

Evaluating Nanobubble-Enriched Water Treatments For Cleaning Stainless Steel Winery Tanks At The Gallo Winery Research Station In Livingston, California, Edgar Godoy-Garcia

Master's Theses

ABSTRACT

Evaluating nanobubble-enriched water treatments for cleaning stainless steel winery tanks at the Gallo winery research station in Livingston, California.

Edgar A. Godoy-Garcia

Sanitation of stainless steel wine storage tanks is a critical component of quality control in commercial winemaking operations. Ineffective cleaning can lead to microbial contamination, product spoilage, and safety concerns. Traditionally, wineries rely on manual scrubbing, chemical cleaning agents, and extensive water rinsing cycles to maintain sanitary tank conditions. However, these methods are resource-intensive and may pose risks to both workers and the environment due to chemical exposure and wastewater generation. In response to growing industry interest …


Emerging Technologies Of Single-Cell Multi-Omics, Yi June Kim, Koichi Takahashi Jun 2025

Emerging Technologies Of Single-Cell Multi-Omics, Yi June Kim, Koichi Takahashi

Faculty, Staff and Student Publications

The heterogeneity of the hematopoietic system was largely veiled by traditional bulk sequencing methods, which measure the averaged signals from mixed cellular populations. In contrast, single-cell sequencing has enabled the direct measurement of individual signals from each cell, significantly enhancing our ability to unveil such heterogeneity. Building on these advances, numerous single-cell multi-omics techniques have been developed into high-throughput, routinely accessible platforms, delineating the precise relationships among different layers of the central dogma in molecular biology. These technologies have uncovered the intricate landscape of genetic clonality and transcriptional heterogeneity in both normal and malignant hematopoietic systems, highlighting their roles in …


Outcomes After Palliative Radiation Therapy In Patients With Symptomatic Locoregionally Advanced Breast Cancer, Luisa E Jacomina, David M Swanson, Melissa P Mitchell, Wendy A Woodward, Benjamin D Smith, Karen E Hoffman, Chelain R Goodman, Haven R Garber, Susie X Sun, Timothy A Yap, Funda Meric-Bernstam, Isidora Y Arzu, Elizabeth S Bloom, Pamela J Schlembach, Eric A Strom, Michael C Stauder, Simona F Shaitelman Jun 2025

Outcomes After Palliative Radiation Therapy In Patients With Symptomatic Locoregionally Advanced Breast Cancer, Luisa E Jacomina, David M Swanson, Melissa P Mitchell, Wendy A Woodward, Benjamin D Smith, Karen E Hoffman, Chelain R Goodman, Haven R Garber, Susie X Sun, Timothy A Yap, Funda Meric-Bernstam, Isidora Y Arzu, Elizabeth S Bloom, Pamela J Schlembach, Eric A Strom, Michael C Stauder, Simona F Shaitelman

Faculty, Staff and Student Publications

Purpose: Symptomatic locoregionally advanced breast cancer (SLABC) can cause troublesome pain or wound complications that negatively impact quality of life. Although palliative radiation therapy (RT) can minimize tumor-related symptoms, how best to tailor RT to achieve the most meaningful and durable response is not well defined.

Methods and materials: This is a single institution, multi-site retrospective review of patients with SLABC treated between 2016 and 2023 with palliative RT to symptomatic disease in the breast, chest wall, and/or regional lymph node basins. Overall survival (OS), locoregional control (LC), clinical and radiographic treatment response, overall pain scores, and treatment-related toxicities were …


Egfr Controls Transcriptional And Metabolic Rewiring In Krasg12d Colorectal Cancer, Dana Krauß, Veronica Moreno-Viedma, Emi Adachi-Fernandez, Cristiano De Sá Fernandes, Jakob-Wendelin Genger, Ourania Fari, Bernadette Blauensteiner, Dominik Kirchhofer, Nikolina Bradaric, Valeriya Gushchina, Georgios Fotakis, Thomas Mohr, Ifat Abramovich, Inbal Mor, Martin Holcmann, Andreas Bergthaler, Arvand Haschemi, Zlatko Trajanoski, Juliane Winkler, Eyal Gottlieb, Maria Sibilia Jun 2025

Egfr Controls Transcriptional And Metabolic Rewiring In Krasg12d Colorectal Cancer, Dana Krauß, Veronica Moreno-Viedma, Emi Adachi-Fernandez, Cristiano De Sá Fernandes, Jakob-Wendelin Genger, Ourania Fari, Bernadette Blauensteiner, Dominik Kirchhofer, Nikolina Bradaric, Valeriya Gushchina, Georgios Fotakis, Thomas Mohr, Ifat Abramovich, Inbal Mor, Martin Holcmann, Andreas Bergthaler, Arvand Haschemi, Zlatko Trajanoski, Juliane Winkler, Eyal Gottlieb, Maria Sibilia

Faculty, Staff and Student Publications

Inhibition of the epidermal growth factor receptor (EGFR) shows clinical benefit in metastatic colorectal cancer (CRC) patients, but KRAS-mutations are known to confer resistance. However, recent reports highlight EGFR as a crucial target to be co-inhibited with RAS inhibitors for effective treatment of KRAS mutant CRC. Here, we investigated the tumor cell-intrinsic contribution of EGFR in KRASG12D tumors by establishing murine CRC organoids with key CRC mutations (KRAS, APC, TP53) and inducible EGFR deletion. Metabolomic, transcriptomic, and scRNA-analyses revealed that EGFR deletion in KRAS-mutant organoids reduced their phenotypic heterogeneity and activated a distinct cancer-stem-cell/WNT signature associated with reduced cell size …


Association Of Sirt6 Expression With Risk Of Pneumonitis Induced By Radiotherapy In Cancer Patients, Fengyuan Yu, Zheng Gong, Yuan Li, Danial F Naseem, Chen Li, Miaowei Wen, Bingying Zhao, Zhezhe Xu, Shanshan Zhang, Rukun Zang, Ailu Wu, Qingxin Han, Shuhui Wu, Hongwei Li, Yipeng Song Jun 2025

Association Of Sirt6 Expression With Risk Of Pneumonitis Induced By Radiotherapy In Cancer Patients, Fengyuan Yu, Zheng Gong, Yuan Li, Danial F Naseem, Chen Li, Miaowei Wen, Bingying Zhao, Zhezhe Xu, Shanshan Zhang, Rukun Zang, Ailu Wu, Qingxin Han, Shuhui Wu, Hongwei Li, Yipeng Song

Faculty, Staff and Student Publications

Thoracic tumours represent a significant proportion of malignant cancers. While radiotherapy (RT) improves prognosis, it can also lead to side effects such as radiation-induced pneumonitis (RP). Since SIRT6 is involved in DNA repair, energy metabolism and inflammation, this study aims to investigate the expression of SIRT6 in lymphocytes as a potential biomarker and therapeutic target for RP. This study included 170 patients diagnosed with thoracic tumours, all of whom underwent thoracic RT. RP was evaluated and classified as severe RP (SRP) and lower as non-severe RP (NSRP). Analyses were performed using SPSS version 26.0 and the R. Among 170 patients …