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Articles 7111 - 7140 of 159538
Full-Text Articles in Entire DC Network
Fish Assemblages And Flow Regimes Upstream And Downstream Of Falcon Reservoir, Christopher J. Austin, Christopher Taylor
Fish Assemblages And Flow Regimes Upstream And Downstream Of Falcon Reservoir, Christopher J. Austin, Christopher Taylor
School of Integrative Biological & Chemical Sciences Faculty Publications
The lower Rio Grande is regulated by Falcon and Amistad dams, as well as series of smaller dams and rock weirs. Several native fish species that rely on a natural flow regime for habitat and spawning are imperiled in the region. We analyzed streamflow discharge above and below Falcon Reservoir to assess potential impacts of dam impoundment on the fishes and flow regime. Fish collections were conducted by seine, and river discharge data was provided by the International Boundaries and Water Commission. We found significant differences in fish assemblages above vs below Falcon Reservoir, and the flow regime was significantly …
Chaperone-Usher Pathway Pili Adhesin Conformations And Inhibitors In Urinary Tract Infections, Edward Lopatto
Chaperone-Usher Pathway Pili Adhesin Conformations And Inhibitors In Urinary Tract Infections, Edward Lopatto
Arts & Sciences Graduate Student Theses and Dissertations
Antibiotic resistant bacteria are becoming increasingly difficult-to-treat resulting in increased morbidity and mortality, especially for common infections such as urinary tract infections (UTIs). Globally, UTIs afflict over 400 million people a year. Numerous different gram-negative and gram-positive bacterial species cause UTIs, including uropathogenic Escherichia coli (UPEC), Klebsiella pneumoniae, and Acinetobacter baumannii. Many of these bacterial species are listed as pathogens of urgent concern by the Center for Disease Control due to the dangerous rise and prevalence of antibiotic resistance necessitating development of new therapeutic measures. Bacteria utilize adhesin factors, such as chaperone-usher pathway (CUP) pili to gain a foothold in …
Cortical Functional Organization In Early Childhood, Jiaxin Tu
Cortical Functional Organization In Early Childhood, Jiaxin Tu
Arts & Sciences Graduate Student Theses and Dissertations
The advent of connectivity-based methods, particularly those utilizing spontaneous BOLD signals, has significantly advanced brain mapping and deepened our understanding of the human brain's functional architecture. While prior research has explored functional organization in early childhood, most studies have focused on coarse, group-level distinctions aligned with adult literature, often within narrow age ranges. This dissertation extends these investigations by examining cortical functional organization in greater detail among healthy infants and toddlers aged 1 to 5 years. Chapter 1 employs spontaneous BOLD signals in sleeping infants and toddlers to derive a group-level functional organization at the resolution of areas and networks. …
Transgenerational Imprints Of Sequential Herbivory Onsoybean Physiology And Fitness Traits, Insha Shaft, Rupesh Kariyat
Transgenerational Imprints Of Sequential Herbivory Onsoybean Physiology And Fitness Traits, Insha Shaft, Rupesh Kariyat
Entomology and Plant Pathology Faculty Publications and Presentations
Sequential herbivory leads to a multitude of effects on plants, influencing processes like growth, physiology, defense, and fitness. However, whether the sequential herbivore attack can elicit any transgenerational consequences is poorly examined. In this study, we show evidence of transgenerational impacts of sequential herbivory by two chewing herbivores, fall armyworm (Spodopterafrugiperda , FAW) and soybean looper (Chrysodeixis includens , SL) on soybean (Glycine max ) progeny. Seeds from the parents subjected to different herbivore sequences (SL-FAW: initial attack by SL followed by FAW and FAW-SL: FAW followed by SL) were used for the transgenerational experiment. Our main hypothesis was that …
Vigorous Physical Activity As A Potential Environmental Risk Factor In Renal Medullary Carcinoma, Daniel D Shapiro, Sagar S Mukhida, Andrew W Hahn, Ayman Isahaku, Schyler M Turner, Jessica P Cheng, Pankaj K Chauhan, Susan S Thomas, Beei Chan, Zita D Lim, Nizar M Tannir, Maria Chang Swartz, Pavlos Msaouel
Vigorous Physical Activity As A Potential Environmental Risk Factor In Renal Medullary Carcinoma, Daniel D Shapiro, Sagar S Mukhida, Andrew W Hahn, Ayman Isahaku, Schyler M Turner, Jessica P Cheng, Pankaj K Chauhan, Susan S Thomas, Beei Chan, Zita D Lim, Nizar M Tannir, Maria Chang Swartz, Pavlos Msaouel
Faculty, Staff and Student Publications
Purpose: Renal medullary carcinoma (RMC) is a rare but aggressive kidney cancer affecting young individuals with sickle hemoglobinopathies. Prior retrospective case-control and mouse modeling studies suggest a mechanism linking vigorous intensity physical activity to increased RMC risk in individuals with sickle hemoglobinopathies. This study aimed to prospectively investigate the association between vigorous intensity exercise and RMC.
Materials and methods: This study used a validated questionnaire to prospectively assess reported physical activity in a large cohort of patients with RMC compared to the activity of individuals without RMC. Between 2022 and 2024, patients with RMC (N = 39) were prospectively surveyed …
Pan-Cancer Immune And Stromal Deconvolution Predicts Clinical Outcomes And Mutation Profiles, Bhavneet Bhinder, Verena Friedl, Sunantha Sethuraman, Davide Risso, Kami E Chiotti, R Jay Mashl, Kyle P Ellrott, Jordan A Lee, Christopher K Wong, Kofi Gyan, Aditya Deshpande, Marcin Imielinski, Rohan Bareja, Josh Stuart, Myron Peto, Katherine A Hoadley, Alexander J Lazar, Andrew D Cherniack, Jingchun Zhu, Shaolong Cao, Mark Rubin, Wenyi Wang, Oliver F Bathe, Nicolas Robine, Li Ding, Peter W Laird, Wanding Zhou, Hui Shen, Vésteinn Thorsson, Jen Jen Yeh, Matthew H Bailey, Daniel Cui Zhou, Xianlu L Peng, Mary Goldman, Yongsheng Li, Anil Korkut, Nidhi Sahni, D Neil Hayes, Michael K A Mensah, Ina Felau, Anab Kemal, Samantha Caesar-Johnson, John A Demchok, Liming Yang, Martin L Ferguson, Roy Tarnuzzer, Zhining Wang, Jean C Zenklusen, Paul Spellman, Olivier Elemento
Pan-Cancer Immune And Stromal Deconvolution Predicts Clinical Outcomes And Mutation Profiles, Bhavneet Bhinder, Verena Friedl, Sunantha Sethuraman, Davide Risso, Kami E Chiotti, R Jay Mashl, Kyle P Ellrott, Jordan A Lee, Christopher K Wong, Kofi Gyan, Aditya Deshpande, Marcin Imielinski, Rohan Bareja, Josh Stuart, Myron Peto, Katherine A Hoadley, Alexander J Lazar, Andrew D Cherniack, Jingchun Zhu, Shaolong Cao, Mark Rubin, Wenyi Wang, Oliver F Bathe, Nicolas Robine, Li Ding, Peter W Laird, Wanding Zhou, Hui Shen, Vésteinn Thorsson, Jen Jen Yeh, Matthew H Bailey, Daniel Cui Zhou, Xianlu L Peng, Mary Goldman, Yongsheng Li, Anil Korkut, Nidhi Sahni, D Neil Hayes, Michael K A Mensah, Ina Felau, Anab Kemal, Samantha Caesar-Johnson, John A Demchok, Liming Yang, Martin L Ferguson, Roy Tarnuzzer, Zhining Wang, Jean C Zenklusen, Paul Spellman, Olivier Elemento
Faculty, Staff and Student Publications
Traditional gene expression deconvolution methods assess a limited number of cell types, therefore do not capture the full complexity of the tumor microenvironment (TME). Here, we integrate nine deconvolution tools to assess 79 TME cell types in 10,592 tumors across 33 different cancer types, creating the most comprehensive analysis of the TME. In total, we found 41 patterns of immune infiltration and stroma profiles, identifying heterogeneous yet unique TME portraits for each cancer and several new findings. Our findings indicate that leukocytes play a major role in distinguishing various tumor types, and that a shared immune-rich TME cluster predicts better …
Supporting Patients With Advanced Cancer And Their Spouses In Parenting Minor Children: Results Of A Randomized Controlled Trial, Kathrin Milbury, Sujin Ann-Yi, Meagan S Whisenant, Morgan Jones, Yisheng Li, Victoria Necroto, Sania D Yousuf, Mariana Chavez-Macgregor, Larrisa Meyers, Eduardo Bruera
Supporting Patients With Advanced Cancer And Their Spouses In Parenting Minor Children: Results Of A Randomized Controlled Trial, Kathrin Milbury, Sujin Ann-Yi, Meagan S Whisenant, Morgan Jones, Yisheng Li, Victoria Necroto, Sania D Yousuf, Mariana Chavez-Macgregor, Larrisa Meyers, Eduardo Bruera
Faculty, Staff and Student Publications
Introduction: Patients with advanced cancer and their spousal caregivers who parent minor children report unmet parenting concerns and increased psychological distress. Seeking to address these important supportive care needs, this RCT examined the feasibility, acceptability, and initial evidence for the efficacy of a novel psychosocial intervention.
Patients and methods: Patients with a metastatic solid malignancy and their spouses completed self-reported validated assessments of psychological symptoms and cancer-related parenting outcomes and were then randomized to the parent support intervention or a usual care (UC) group. Both groups were reassessed 6 and 12 weeks later. Dyads randomized to the counselor-led intervention attended …
The Astrobiological Figure Of Humboldt As Pioneer In The Rock Varnish Research, Jose Jordan-Soria
The Astrobiological Figure Of Humboldt As Pioneer In The Rock Varnish Research, Jose Jordan-Soria
Homage to Alexander von Humboldt: Travels to and from Spain Throughout the Centuries / Homenaje a Alexander von Humboldt: Viajes hacia y desde España de todos los siglos
From Humboldt is particularly interesting -and little know- his description of mineral coatings on rocks 200 years ago, reported in his book Personal Narrative of Travels to the Equinoctial Regions of the New Continent during the years 1799-1804, co-written with Aimé Bonpland, for which is considerate the father of rock coating research. On June 5th 1799 set sail from A Coruña -Spain- to Cumaná -Venezuela- beginning five years of expedition. While they explored the Orinoco River system, in th eriver basin waterfalls, Humboldt observed the presence of dark coating depositions. He ascertained a manganese-rich accretion, reporting similar structures in other …
Implementing A Sustainability Approach By Converting Plastic Bottle Waste From A Mischievous Substance To A Beneficial Material By Means Of Zero Residue Level Concept, Younus Mohammed Abed, Fatima Allawi, Shahad Mudhafar Ali, Salem Jawad Alhamd, Thekra Atta Ibrahim, Mohammed Nsaif Abbas
Implementing A Sustainability Approach By Converting Plastic Bottle Waste From A Mischievous Substance To A Beneficial Material By Means Of Zero Residue Level Concept, Younus Mohammed Abed, Fatima Allawi, Shahad Mudhafar Ali, Salem Jawad Alhamd, Thekra Atta Ibrahim, Mohammed Nsaif Abbas
Karbala International Journal of Modern Science
Plastic waste represents a serious environmental and health hazard due to its non-biodegradability and toxic leachates. This study investigates the potential conversion of plastic waste into a sustainable raw material for producing a useful substance. This investigation focuses on repurposing PET beverage bottles—a major contributor to microplastic pollution—into high-value activated carbon (AC) for water treatment, aligning with circular economy principles. The chemical preparation method for AC using phosphoric acid as an activating agent was evaluated. Results demonstrated the successful conversion of 68% of plastic waste into AC under the following conditions: pyrolysis temperature of 700°C, pyrolysis time of 7 hours, …
Robust Embeddings Of Genetics, Anatomy, And State Decoded From A Neuron’S Activity, Aidan Schneider
Robust Embeddings Of Genetics, Anatomy, And State Decoded From A Neuron’S Activity, Aidan Schneider
Arts & Sciences Graduate Student Theses and Dissertations
Neural spike trains are shaped by both extrinsic inputs and intrinsic structural constraints. While prior work has focused on how spike timing encodes externally driven variables, such as stimuli or behavior, this dissertation explores whether principles that organize neural activity in space and time—such as genetic cell type, anatomical location, and arousal state—are also embedded in the spiking output of individual neurons. I hypothesize that these organizing principles are not quenched as irrelevant variability, but rather multiplexed within the neural code itself. To test this, I attempt to decode these principles from the spike trains of neurons recorded in behaving …
Correction: Turn-On Fluorescent Glucose Transport Bioprobe Enables Wash-Free Real-Time Monitoring Of Glucose Uptake Activity In Live Cells And Small Organisms, Monica S. Hensley, David Hutchings, Abdelrahman Ismail, Micaela Rayne Geborkoff, Thomas Werner, Marina Tanasova
Correction: Turn-On Fluorescent Glucose Transport Bioprobe Enables Wash-Free Real-Time Monitoring Of Glucose Uptake Activity In Live Cells And Small Organisms, Monica S. Hensley, David Hutchings, Abdelrahman Ismail, Micaela Rayne Geborkoff, Thomas Werner, Marina Tanasova
Michigan Tech Publications
Correction for “Turn-on fluorescent glucose transport bioprobe enables wash-free real-time monitoring of glucose uptake activity in live cells and small organisms” by Monica S. Hensley et al., RSC Chem. Biol., 2025, 6, 987–995, https://doi.org/10.1039/D4CB00239C.
The authors regret that two contributors, Micaela Rayne Geborkoff and Professor Dr Thomas Werner, were inadvertently omitted from the original author list of this article. Both individuals made significant contributions to the research reported.
Micaela Rayne Geborkoff was involved in the design, planning, and execution of the Drosophila experiments, specifically in the growth and treatment of fruit fly larvae. Professor Dr Thomas Werner provided …
Response Of Various Body Parts Of House Flies, Musca Domestica, To Sucrose, Panchalie B. Gunathunga, Merveille Muyizere, Bethia H. King
Response Of Various Body Parts Of House Flies, Musca Domestica, To Sucrose, Panchalie B. Gunathunga, Merveille Muyizere, Bethia H. King
Faculty Articles, Papers, and Other Scholarship
Insects use multiple body parts, not just their mouth, to taste. Whether a particular body part has a taste function can be determined by examining the morphology or electrophysiological response of its sensilla (sense organs) or by its behavioral response. The present study investigated taste response of each of the three pairs of tarsi, tibiae, femurs, as well as the antennae and wings, in house flies, Musca domestica L. (Diptera: Muscidae). This was done by measuring the proboscis extension response (PER), and in the case of the wings, also the grooming behavior. PER is a visible precursor to consumption. The …
Genome-Wide Association Study For Lung Cancer In 6531 African Americans Reveals New Susceptibility Loci, Jinyoung Byun, Younghun Han, Jiyeon Choi, Ryan Sun, Vikram R Shaw, Catherine Zhu, Xiangjun Xiao, Christine Lusk, Hoda Badr, Hyun-Sung Lee, Hee-Jin Jang, Yafang Li, Hyeyeun Lim, Erping Long, Yanhong Liu, Linda Kachuri, Kyle M Walsh, John K Wiencke, Demetrius Albanes, Stephen Lam, Adonina Tardon, Marian L Neuhouser, Matt J Barnett, Chu Chen, Stig Bojesen, Hermann Brenner, Maria Teresa Landi, Mattias Johansson, Angela Risch, H-Erich Wichmann, Heike Bickeböller, David C Christiani, Gad Rennert, Susanne Arnold, John K Field, Sanjay Shete, Loic Le Marchand, Geoffrey Liu, Angeline S Andrew, Shanbeh Zienolddiny, Kjell Grankvist, Mikael Johansson, Neil Caporaso, Fiona Taylor, Philip Lazarus, Matthew B Schabath, Melinda C Aldrich, Alpa Patel, Xihong Lin, Krista A Zanetti, Curtis C Harris, Stephen Chanock, James Mckay, Ann G Schwartz, Rayjean J Hung, Christopher I Amos
Genome-Wide Association Study For Lung Cancer In 6531 African Americans Reveals New Susceptibility Loci, Jinyoung Byun, Younghun Han, Jiyeon Choi, Ryan Sun, Vikram R Shaw, Catherine Zhu, Xiangjun Xiao, Christine Lusk, Hoda Badr, Hyun-Sung Lee, Hee-Jin Jang, Yafang Li, Hyeyeun Lim, Erping Long, Yanhong Liu, Linda Kachuri, Kyle M Walsh, John K Wiencke, Demetrius Albanes, Stephen Lam, Adonina Tardon, Marian L Neuhouser, Matt J Barnett, Chu Chen, Stig Bojesen, Hermann Brenner, Maria Teresa Landi, Mattias Johansson, Angela Risch, H-Erich Wichmann, Heike Bickeböller, David C Christiani, Gad Rennert, Susanne Arnold, John K Field, Sanjay Shete, Loic Le Marchand, Geoffrey Liu, Angeline S Andrew, Shanbeh Zienolddiny, Kjell Grankvist, Mikael Johansson, Neil Caporaso, Fiona Taylor, Philip Lazarus, Matthew B Schabath, Melinda C Aldrich, Alpa Patel, Xihong Lin, Krista A Zanetti, Curtis C Harris, Stephen Chanock, James Mckay, Ann G Schwartz, Rayjean J Hung, Christopher I Amos
Faculty, Staff and Student Publications
Despite lung cancer affecting all races and ethnicities, disparities are observed in incidence and mortality rates among different ethnic groups in the United States. Non-Hispanic African Americans had a high incidence rate of lung cancer at 55.8 per 100 000 people, as well as the highest death rate at 37.2 per 100 000 people from 2016 to 2020. While previous genome-wide association studies (GWAS) have identified over 45 susceptibility risk loci that influence lung cancer development, few GWAS have investigated the etiology of lung cancer in African Americans. To address this gap in knowledge, we conducted GWAS of lung cancer …
Direct Inhibition Of Ras Reveals The Features Of Oncogenic Signaling Driven By Ras G12 And Q61 Mutations, Michelangelo Marasco, Dinesh Kumar, Santiago Garcia Borrego, Tessa Seale, Giulia Maddalena, Riccardo Mezzadra, Kylie Belanger, Soren Cole, Brayan Perez, Wei Luan, Radha Mukherjee, Ilinca Aricescu, Vladimir Markov, Yuxin Zhu, Sabrina Arena, Alberto Bardelli, Elisa De Stanchina, Scott W Lowe, Richard A Burkhart, Jacquelyn W Zimmerman, Rona Yaeger, Scott E Kopetz, Neal Rosen, Sandra Misale
Direct Inhibition Of Ras Reveals The Features Of Oncogenic Signaling Driven By Ras G12 And Q61 Mutations, Michelangelo Marasco, Dinesh Kumar, Santiago Garcia Borrego, Tessa Seale, Giulia Maddalena, Riccardo Mezzadra, Kylie Belanger, Soren Cole, Brayan Perez, Wei Luan, Radha Mukherjee, Ilinca Aricescu, Vladimir Markov, Yuxin Zhu, Sabrina Arena, Alberto Bardelli, Elisa De Stanchina, Scott W Lowe, Richard A Burkhart, Jacquelyn W Zimmerman, Rona Yaeger, Scott E Kopetz, Neal Rosen, Sandra Misale
Faculty, Staff and Student Publications
RAS genes are frequently mutated in cancer, often at codons 12 and 61. With the recent introduction of RAS inhibitors, we can now directly investigate the effects of specific RAS mutations in cancer cells. In this study, we demonstrate that in tumors with RASG12X mutations, mutant RAS can be activated by receptor tyrosine kinases (RTK), and PI3K activation is dependent on mutant RAS. Conversely, RASQ61X mutations activate the MAPK cascade independently of RTKs, and inhibition of RASQ61X impairs MAPK pathway activation but leaves the PI3K pathway unaffected. Our characterization of these distinct features of G12X and Q61X mutations suggests that …
First Case Of Sexual Cannibalism In Leiurus Abdullahbayrami Yağmur, Koç & Kunt, 2009 (Scorpiones: Buthidae) From Lebanon, Rami Khashab
First Case Of Sexual Cannibalism In Leiurus Abdullahbayrami Yağmur, Koç & Kunt, 2009 (Scorpiones: Buthidae) From Lebanon, Rami Khashab
Euscorpius
This study presents the first report of sexual cannibalism in the medically significant scorpion Leiurus abdullahbayrami Yağmur, Koç & Kunt, 2009, that was recorded during a herpetological field trip to the semi-desert area in northern Lebanon. It broadens the understanding of sexual cannibalism in scorpions and adds a new prey item to the dietary spectrum of the scorpion.
Stream Fish Assemblage Dynamics And Barriers To Aquatic Connectivity In The Ichawaynochaway Creek Watershed, Georgia, Usa, Jake R. Duhé
Stream Fish Assemblage Dynamics And Barriers To Aquatic Connectivity In The Ichawaynochaway Creek Watershed, Georgia, Usa, Jake R. Duhé
LSU Master's Theses
Stream fishes in the southeastern United States are adapted to hydrological disturbances such as droughts. However, this region is projected to experience increasingly frequent and severe disturbances that will elevate water demands given increasing agricultural and urban development. Further, road-stream crossings (RSCs) are abundant features in these streams that can exacerbate drought-mediated stream fragmentation and impede movements by many aquatic organisms, including fishes, when poorly constructed. These compounding effects may adversely affect the diversity and abundances of resident stream fishes, but their interactions remain poorly understood, warranting rigorous testing of how droughts and RSCs influence stream fish dynamics. I assessed …
Irradiation Of Prostate Cancer Alters Circulating Small Extracellular Vesicle Functions, Aejaz Sayeed, Vaughn Garcia, Cecilia E. Verrillo, Rachel M. Derita, Md Niamat Hossain, Shiv R. Krishn, Samuel Sey, Christopher D. Shields, Adrian D. Altieri, Qin Liu, Khalid Sossey-Alaoui, William K. Kelly, Lucia R. Languino
Irradiation Of Prostate Cancer Alters Circulating Small Extracellular Vesicle Functions, Aejaz Sayeed, Vaughn Garcia, Cecilia E. Verrillo, Rachel M. Derita, Md Niamat Hossain, Shiv R. Krishn, Samuel Sey, Christopher D. Shields, Adrian D. Altieri, Qin Liu, Khalid Sossey-Alaoui, William K. Kelly, Lucia R. Languino
Department of Pharmacology, Physiology, and Cancer Biology Faculty Papers
It is known that β1 integrins and a downstream signaling molecule c-Src are upregulated in prostate cancer (PrCa) tissues, are co-expressed in circulating small extracellular vesicles (sEVs) and contribute to cancer progression. Here, we demonstrate that sEVs from PrCa patients show robust expression of both β1 integrins and c-Src. The impact of irradiation, a widely used therapy for the treatment of PrCa, on circulating sEVs is however not fully understood. We show that sEVs isolated from the plasma of transgenic adenocarcinoma of mouse prostate (TRAMP) mice, stimulate migration and anchorage-independent growth of recipient cancer cells, but sEVs are not active …
Z-Scores Outperform Similar Methods For Analyzing Crispr Paralog Synthetic Lethality Screens, Juihsuan Chou, Nazanin Esmaeili Anvar, Reem Elghaish, Junjie Chen, Traver Hart
Z-Scores Outperform Similar Methods For Analyzing Crispr Paralog Synthetic Lethality Screens, Juihsuan Chou, Nazanin Esmaeili Anvar, Reem Elghaish, Junjie Chen, Traver Hart
Faculty, Staff and Student Publications
Genetic screens offer a promising strategy for identifying tumor-specific therapeutic targets, but single-gene knockout screens often miss functionally redundant paralogs. Multiplex Cas9 and Cas12a CRISPR systems have been deployed to assay genetic interactions, but analysis pipelines vary considerably. Here we evaluate data from four in4mer CRISPR/Cas12a screens in cancer cell lines, using delta log fold change, Z-transformed dLFC, and rescaled dLFC approaches to identify synthetic lethal interactions. Both ZdLFC and RdLFC provide more consistent identification of synthetic lethal pairs across cell lines compared to the unscaled dLFC method, while ZdLFC benefits from not requiring a training set of known interactors.
Vibrio Cholerae Endemic To The Lower Rio Grande Delta Segregate Into Urban And Rural Phylotypes, Daniele Provenzano, Jeffrey W. Turner, Jorge Duran-Gonzalez, David A. Laughlin, David Silva, Viviana Trevino, Miguel F. Gonzales, Boris Ermolinsky, Stefan Pukatzki
Vibrio Cholerae Endemic To The Lower Rio Grande Delta Segregate Into Urban And Rural Phylotypes, Daniele Provenzano, Jeffrey W. Turner, Jorge Duran-Gonzalez, David A. Laughlin, David Silva, Viviana Trevino, Miguel F. Gonzales, Boris Ermolinsky, Stefan Pukatzki
School of Integrative Biological & Chemical Sciences Faculty Publications
The lifestyle of Vibrio cholerae is primarily environmental, yet a chance encounter with a human host can lead to cholera, a potentially lethal form of diarrhea. Strains belonging to O1 and O139 serogroups have pandemic potential, but the contribution of non-O1/non-O139 serovars towards the genesis of cholera remains unclear. Endemic V. cholerae lineages were investigated given several historical accounts describing cholera epidemics and sporadic, contemporary cholera-like outbreaks along the lower Rio Grande Delta (LRGD). Seven isolates were recovered from an urban segment of the Rio Grande and six from a rural segment where the river empties into the Gulf of …
Genetic Gain And Loss In The Evolution Of Amniote T Cell Receptor And Immunoglobulin Genes, Jordan M. Sampson
Genetic Gain And Loss In The Evolution Of Amniote T Cell Receptor And Immunoglobulin Genes, Jordan M. Sampson
Biology ETDs
The immune system of most jawed vertebrates consists of three major cell types: αβ T cells, γδ T cells, and B cells. Every species evaluated contains the loci that encode the highly conserved αβ T cells, however, γδ T cells are less conserved and have been lost in squamate reptiles. The loci that encode the B cell receptor have also varied across evolution. Seven immunoglobulin (Ig) heavy chain isotypes have been identified in amniotes: IgM, IgD, IgY, IgG, IgE, IgO, and IgA. Some are found in most species (IgM and IgD) and others only in specific lineages (IgY or IgG). …
Differential Efficacy Of Bevacizumab And Erlotinib In Preclinical Models Of Renal Medullary Carcinoma And Fumarate Hydratase-Deficient Renal Cell Carcinoma, Niki M Zacharias, Manuel Ozambela, Menuka Karki, Rong He, Pankaj K Chauhan, Pedro I Pesquera, Andres E Hernandez Gonzalez, Oscar Ochoa, Alberto Pieretti, Huiqin Chen, Carolyn De La Cerda, Zhiyuan Yu, Abha Grover, Samantha Hicks-Peña, Natalie W Fowlkes, Lei Wang, Tapati Maity, Priya Rao, Giannicola Genovese, Nizar M Tannir, Jose A Karam, Pavlos Msaouel
Differential Efficacy Of Bevacizumab And Erlotinib In Preclinical Models Of Renal Medullary Carcinoma And Fumarate Hydratase-Deficient Renal Cell Carcinoma, Niki M Zacharias, Manuel Ozambela, Menuka Karki, Rong He, Pankaj K Chauhan, Pedro I Pesquera, Andres E Hernandez Gonzalez, Oscar Ochoa, Alberto Pieretti, Huiqin Chen, Carolyn De La Cerda, Zhiyuan Yu, Abha Grover, Samantha Hicks-Peña, Natalie W Fowlkes, Lei Wang, Tapati Maity, Priya Rao, Giannicola Genovese, Nizar M Tannir, Jose A Karam, Pavlos Msaouel
Faculty, Staff and Student Publications
Renal medullary carcinoma (RMC) and fumarate hydratase (FH)-deficient renal cell carcinoma (RCC) are rare and highly aggressive cancers. Although the combination of vascular endothelial growth factor (VEGF) inhibition by bevacizumab and epidermal growth factor receptor (EGFR) inhibition by erlotinib is clinically used for both diseases, the differential effect of each component has not been investigated. Transcriptomic profiling revealed that RMC and FH-deficient tumor tissues demonstrate increased EGFR but not VEGF expression compared with adjacent normal kidney. Subsequent in vitro studies revealed that RMC and FH-deficient cell lines are sensitive to erlotinib treatment, whereas clear cell RCC cell lines are resistant. …
Immature Acta2r179c/+ Smooth Muscle Cells Cause Moyamoya-Like Cerebrovascular Lesions In Mice Prevented By Boosting Oxphos, Anita Kaw, Suravi Majumder, Jose E Esparza Pinelo, Ting Wu, Zbigniew Starosolski, Zhen Zhou, Albert J Pedroza, Xueyan Duan, Kaveeta Kaw, Angie D Gonzalez, Ripon Sarkar, Michael P Fischbein, Philip L Lorenzi, Lin Tan, Sara A Martinez, Iqbal Mahmud, Laxman Devkota, L Maximilian Buja, Heinrich Taegtmeyer, Ketan B Ghaghada, Sean P Marrelli, Callie S Kwartler, Dianna M Milewicz
Immature Acta2r179c/+ Smooth Muscle Cells Cause Moyamoya-Like Cerebrovascular Lesions In Mice Prevented By Boosting Oxphos, Anita Kaw, Suravi Majumder, Jose E Esparza Pinelo, Ting Wu, Zbigniew Starosolski, Zhen Zhou, Albert J Pedroza, Xueyan Duan, Kaveeta Kaw, Angie D Gonzalez, Ripon Sarkar, Michael P Fischbein, Philip L Lorenzi, Lin Tan, Sara A Martinez, Iqbal Mahmud, Laxman Devkota, L Maximilian Buja, Heinrich Taegtmeyer, Ketan B Ghaghada, Sean P Marrelli, Callie S Kwartler, Dianna M Milewicz
Faculty, Staff and Student Publications
ACTA2 pathogenic variants altering arginine 179 cause childhood-onset strokes due to moyamoya disease (MMD)-like occlusions of the distal internal carotid arteries, but the mechanisms of pathogenesis are unknown and no preventive treatments exist. Here we show that Acta2R179C/+ smooth muscle cells (SMCs) fail to fully differentiate and maintain stem cell-like features, including increased migration and glycolytic flux compared to wildtype (WT) SMCs. Increasing mitochondrial respiration with nicotinamide riboside (NR) drives differentiation and decreases migration of Acta2R179C/+ SMCs. Carotid artery injury of Acta2SMC-R179C/+ mice leads to premature death, intraluminal SMC accumulation leading to MMD-like occlusive lesions, neurologic symptoms, …
Structural And Functional Characterization Of Creb-Binding Protein (Crebbp) As A Histone Propionyltransferase, Guiling Cui, Marie Ley, Ariel E Mechaly, Linh-Chi Bui, Christina Michail, Jérémy Berthelet, Julien Dairou, Haopeng Yang, Guillaume Chevreux, Gautier Moroy, Michael R Green, Ahmed Haouz, Fernando Rodrigues Lima
Structural And Functional Characterization Of Creb-Binding Protein (Crebbp) As A Histone Propionyltransferase, Guiling Cui, Marie Ley, Ariel E Mechaly, Linh-Chi Bui, Christina Michail, Jérémy Berthelet, Julien Dairou, Haopeng Yang, Guillaume Chevreux, Gautier Moroy, Michael R Green, Ahmed Haouz, Fernando Rodrigues Lima
Faculty, Staff and Student Publications
In addition to histone acetylation, histone lysine propionylation (such as the H3K18Pr mark) has recently attracted significant attention as a common and abundant modification linking the cellular metabolic state and gene expression. CREB-binding protein (CREBBP) and EP300 are key histone acetyltransferases that play a critical role in gene expression through their catalytic activity. Although CREBBP and EP300 are homologous enzymes with high structural similarities, they exhibit both redundant and specific functions. Dissecting the shared and divergent properties of CREBBP and EP300 is thus important to understand their roles. However, despite the importance of CREBBP, most mechanistic and structural studies have …
Cat: A Conditional Association Test For Microbiome Data Using A Permutation Approach, Yushu Shi, Liangliang Zhang, Kim-Anh Do, Robert R Jenq, Christine B Peterson
Cat: A Conditional Association Test For Microbiome Data Using A Permutation Approach, Yushu Shi, Liangliang Zhang, Kim-Anh Do, Robert R Jenq, Christine B Peterson
Faculty, Staff and Student Publications
In microbiome analysis, researchers often seek to identify taxonomic features associated with an outcome of interest. However, microbiome features are intercorrelated and linked by phylogenetic relationships, making it challenging to assess the association between an individual feature and an outcome. This paper proposes a novel conditional association test, CAT, that can account for other features and phylogenetic relatedness when testing the association between a feature and an outcome. CAT adopts a permutation approach, measuring the importance of a feature in predicting the outcome by permuting operational taxonomic unit/amplicon sequence variant counts belonging to that feature from the data and quantifying …
A Hedgehog-Foxf Axis Coordinates Dental Follicle-Derived Alveolar Bone Formation, Mizuki Nagata, Gaurav T Gadhvi, Taishi Komori, Yuki Arai, Chiaki Tsutsumi-Arai, Angel Ka Yan Chu, Seth N Nye, Yuntao Yang, Shion Orikasa, Akira Takahashi, Peter Carlsson, W Jim Zheng, Joshua D Welch, Noriaki Ono, Wanida Ono
A Hedgehog-Foxf Axis Coordinates Dental Follicle-Derived Alveolar Bone Formation, Mizuki Nagata, Gaurav T Gadhvi, Taishi Komori, Yuki Arai, Chiaki Tsutsumi-Arai, Angel Ka Yan Chu, Seth N Nye, Yuntao Yang, Shion Orikasa, Akira Takahashi, Peter Carlsson, W Jim Zheng, Joshua D Welch, Noriaki Ono, Wanida Ono
Faculty, Staff and Student Publications
The alveolar bone is a specialized mineralized structure supporting the lifelong functionality of the tooth in mastication. The alveolar bone develops from the dental follicle (DF) during tooth root formation due to deliberate epithelial-mesenchymal interactions. However, how DF progenitor cell fates are regulated toward alveolar bone osteoblasts remains unknown. We find that Hedgehog signaling activities are transiently activated during the onset of tooth root formation and alveolar bone formation. Parathyroid hormone-related protein (PTHrP)-expressing DF cells are highly responsive to Hedgehog signaling, yet constitutive Hedgehog activation using Pthrp-creER and Ptch1-floxed alleles potently suppresses alveolar osteoblast and ligament differentiation of PTHrP+ DF …
Scorpions Of The Horn Of Africa (Arachnida: Scorpiones). Part Xxxix. Buthus Pygmaeus Sp. N. From Somaliland (Buthidae), František Kovařík, Graeme Lowe, František Šťáhlavský, Hassan Sh A. Elmi
Scorpions Of The Horn Of Africa (Arachnida: Scorpiones). Part Xxxix. Buthus Pygmaeus Sp. N. From Somaliland (Buthidae), František Kovařík, Graeme Lowe, František Šťáhlavský, Hassan Sh A. Elmi
Euscorpius
New data are presented on the distribution of the genus Buthus Leach, 1815 in the Horn of Africa, mainly in Somaliland. B. pygmaeus sp. n. is described, fully complemented with color photographs of live and preserved specimens, as well as their habitats. In addition to the analysis of external morphology and hemispermatophors, we provide a description of the karyotype of B. pygmaeus sp. n. (2n=22). A key and distribution map of Buthus in the Horn of Africa (six species) are included
Preferred Plants And Nectar Collecting Times For Honey Production, David Macfawn, Jennifer M.K. O'Keefe, Sophie Warny, Carol Wymer, June Rampy Ponder
Preferred Plants And Nectar Collecting Times For Honey Production, David Macfawn, Jennifer M.K. O'Keefe, Sophie Warny, Carol Wymer, June Rampy Ponder
Clemson Extension Publishing
This book addresses three important questions for South Carolina beekeepers – which plants are bees in South Carolina using for nectar forage, when bees collect nectar from those plants, and how can understanding nectar foraging habits inform beekeepers as they work to gather specific types of premium honey? In 2021, the South Carolina Beekeeper’s Association, led by David MacFawn, designed and implemented a statewide pollen study, the first in any state in over fifty years, to answer these questions. Informed by data gathered from 19 apiaries across the state, this book contains the results of that study, including large-scale melissopalynological …
Macrophage Subsets In Cardiomyocyte Interaction And Infarct Repair In Heart Failure, Jolissa Davis-Mccrea, Yuhui Yang, Huilan Tan, Yajing Wang
Macrophage Subsets In Cardiomyocyte Interaction And Infarct Repair In Heart Failure, Jolissa Davis-Mccrea, Yuhui Yang, Huilan Tan, Yajing Wang
Expo Student Presentations
2025 Summer Expo Poster Presentation
- Biological & Life Sciences
- Health Sciences & Health Professions
Commentary On Blaser's "Antibiotic Use And Its Consequences For The Normal Microbiome", Fred C. Tenover
Commentary On Blaser's "Antibiotic Use And Its Consequences For The Normal Microbiome", Fred C. Tenover
AMR Commentary
If you have not read this eye-opening commentary by Dr. Martin Blaser about the negative impact of the widespread use of antibiotics in children, you should. The goal of giving antibiotics to children usually is to treat an infection — an earache, a respiratory tract infection, or perhaps a potentially deadly bloodstream infection. Those antibiotics, however, will often kill more than just the bacteria that are causing the infection. Humans have large quantities of “good bacteria” in our intestinal tracts, on our skin, and elsewhere on our body that play an important role in keeping us healthy.
Prior To Termination, The Rye Cover Crop Increased The Soil Methane Sink, Shailesh Pandit, Graig W. Reicks, Janet Moriles Miller, Deepak R. Joshi, Sharon A. Clay, David E. Clay
Prior To Termination, The Rye Cover Crop Increased The Soil Methane Sink, Shailesh Pandit, Graig W. Reicks, Janet Moriles Miller, Deepak R. Joshi, Sharon A. Clay, David E. Clay
Agronomy, Horticulture and Plant Science Faculty Publications
Even though the impact of cover crops on soil moisture has been well documented, little work has investigated the resulting impact on methane emissions. Therefore, the objective was to determine the influence of a dormant seeded rye (Secale cereale) cover crop on soil temperatures, soil moisture, inorganic N, and total CH4-C emission in a well-drained frigid soil from the start of growth in April/May through corn's (Zea mays) V4 growth stage. In this study, soil moisture, temperature, CH4-C, and N2O-N fluxes were measured near-continuously. The rye cover crop: (1) reduced …