Open Access. Powered by Scholars. Published by Universities.®

Digital Commons Network™

Open Access. Powered by Scholars. Published by Universities.®

Life Sciences

Institution
Keyword
Publication Year
Publication
Publication Type
File Type

Articles 4411 - 4440 of 159498

Full-Text Articles in Entire DC Network

Modeling Mineral Redistribution In Biological Tissue Using Apple As An In Vitro Analogue, Daler Djuraev, Ali Algemsh, Halima Alazeb, Zeenia Ahmed Dec 2025

Modeling Mineral Redistribution In Biological Tissue Using Apple As An In Vitro Analogue, Daler Djuraev, Ali Algemsh, Halima Alazeb, Zeenia Ahmed

Publications and Research

This project aims to model mineral (ion) redistribution that occurs in human soft tissue after injury or mechanical/thermal stress. Because direct, repeatable in vivo measurements are difficult, we use apples as an in vitro analogue: their mineral content is relatively uniform and the tissue can be cut, dried, and repeatedly imaged under controlled conditions. Using X-ray imaging, we tracked how minerals in apple tissue move toward damaged regions immediately after cutting, and how subsequent drying at room temperature drives a redistribution toward the central core. We also observed that biological degradation (decay) alters mineral density over time, indicating that even …


Metamaterial-Based Microstrip Antenna For Safe Detection Of Tiny Breast Tumors, Shrouk E. El-Sawy, Mohamed G. Abdelfattah, Nihal F.F. Areed, Ahmed Shaban Samra Dec 2025

Metamaterial-Based Microstrip Antenna For Safe Detection Of Tiny Breast Tumors, Shrouk E. El-Sawy, Mohamed G. Abdelfattah, Nihal F.F. Areed, Ahmed Shaban Samra

Mansoura Engineering Journal

This study describes the construction of a compact microstrip patch antenna (MPA) with a triangular-shaped metamaterial layer for the safe detection of tiny breast tumors at 2.4 GHz. The metamaterial considerably improves the antenna's gain and directivity when compared to typical designs that do not include it, resulting in improved detection performance. The radiating patch of proposed antenna measures 29.3 × 38 × 1.6 mm and has been tested through simulations and experimental tests, exhibiting successful tumor identification in a realistic breast phantom. The results of both calculations and testing demonstrate a sensitivity of 6.643 dB/mm, allowing for precise detection …


A New Subspecies Of Celastrina Lucia (W. Kirby) (Lycaenidae: Polyommatinae) In The Central Appalachian Mountain Region, Harry Pavulaan Dec 2025

A New Subspecies Of Celastrina Lucia (W. Kirby) (Lycaenidae: Polyommatinae) In The Central Appalachian Mountain Region, Harry Pavulaan

The Taxonomic Report of the International Lepidoptera Survey

The Celastrina (“Azure”) populations of the central Appalachian Mountain region have traditionally been identified as Celastrina ladon (Cramer) by numerous authors. However, the discovery of elongated dorsal wing scales in males of C. ladon (Wright & Pavulaan, 1999; Ômura et al., 2015) established that this diagnostic trait is limited to C. ladon, C. nigra (W. Forbes), and subsequently C. iryna (Pavulaan). Microscopic examination of male “Spring Azure” specimens from higher elevations in the Appalachian Mountains revealed a complete absence of these elongated scales in the resident populations, despite their outward resemblance to C. ladon …


The Relationship Between Light Physical Activity And 10-Year Weight Change In 2,868 U.S. Adults: A National Health And Nutrition Examination Survey Investigation, Chloe Diane Cory Dec 2025

The Relationship Between Light Physical Activity And 10-Year Weight Change In 2,868 U.S. Adults: A National Health And Nutrition Examination Survey Investigation, Chloe Diane Cory

Theses and Dissertations

The prevalence of obesity has steadily increased over the past several decades. About 13.4% of Americans aged 20-74 had obesity in 1960-1962 and the prevalence has steadily increased to 40.3% in 2021-2023--more than a 3-fold increase. PURPOSE: The aim of this study was to evaluate the relationship between time spent in light physical activity (LPA) and 10-year weight change in a random sample of 2868 women and men representative of the U.S. adult population. METHODS: Data were used from the National Health and Nutrition Examination Survey (NHANES) from the 2003-2006 data cycles. Participants were limited to non-pregnant U.S. …


A Geological And Geochemical Study Of The Philipsburg Mining District, Granite County, Montana, Celine M. Beaucamp Dec 2025

A Geological And Geochemical Study Of The Philipsburg Mining District, Granite County, Montana, Celine M. Beaucamp

Graduate Theses & Non-Theses

The Philipsburg district, renowned for its rich mining history, has contributed significantly to Montana's mineral production, ranking as the state's second-most productive district. Active from 1865 to the 1980s, it yielded an impressive array of Ag (50-60 million oz), with notable outputs of Au, Zn, Pb, Cu, and battery-grade MnO2. The district features Cordilleran polymetallic veins, some of which are along bedding in Mississippian and Devonian limestone, and others are steeply dipping quartz veins in silicate-rich sedimentary rocks and in the Philipsburg batholith. The veins exhibit a district-wide mineral zonation, marked by Cu- and Ag-rich ores near granite porphyries, with …


Aqueous Geochemistry Drives Microbial Cu, Fe, And Zn Uptake Rates In Yellowstone, A Continental Hydrothermal System, Eva Carolina Andrade-Barahona Dec 2025

Aqueous Geochemistry Drives Microbial Cu, Fe, And Zn Uptake Rates In Yellowstone, A Continental Hydrothermal System, Eva Carolina Andrade-Barahona

Graduate Theses & Non-Theses

Microbial uptake of trace metal cofactors such as copper (Cu), iron (Fe), and zinc (Zn) is governed by biogeochemical processes in hydrothermal systems where metal bioavailability varies widely. In situ microbial metal uptake rates were quantified by applying metal stable isotope probing (MSIP) in the Yellowstone hydrothermal system across diverse geochemical conditions in hydrothermal springs. The findings in these studies revealed that pH exerts a dominant influence on microbial copper uptake rate, also enhanced by increased Cu²⁺ ion availability and dissolved oxygen. Microbial iron uptake, in contrast, displayed a broad tolerance to environmental variability, occurring across a pH range of …


Functional Impact Of Single Nucleotide Polymorphism Rs4129009 (Ile775val) On Human Toll-Like Receptor 10, Audrey N. Koti Dec 2025

Functional Impact Of Single Nucleotide Polymorphism Rs4129009 (Ile775val) On Human Toll-Like Receptor 10, Audrey N. Koti

Biology Student Research

Toll-like receptors (TLRs) are a subclass of pattern recognition receptors within the

innate immune system that detect pathogen-associated and danger-associated molecular patterns,

thereby initiating host defense responses. The human TLR family comprises ten receptors (TLR1

– TLR10), each recognizing structurally conserved microbial motifs such as bacterial

lipoproteins and viral nucleic acids. The ligand specificities, adaptor protein recruitment, and

downstream signaling cascades have been well-characterized for TLR1 – TLR9, which

predominantly engage MyD88- or TRIF-dependent pathways to activate pro-inflammatory

transcription factors including NF-κB. In contrast, the ligand specificity and intracellular

signaling mechanisms of TLR10 have yet to be fully elucidated. Emerging …


Mental Health Literacy In Biology Graduate Teaching Assistants: Perception, Knowledge, And Training Needs In College Stem Education, Kanza Arshad, Ricardo Montoya, Nicole Scheuermann, Heather E. Bergan-Roller Dec 2025

Mental Health Literacy In Biology Graduate Teaching Assistants: Perception, Knowledge, And Training Needs In College Stem Education, Kanza Arshad, Ricardo Montoya, Nicole Scheuermann, Heather E. Bergan-Roller

Honors Capstones

College students experience a high prevalence of mental health challenges, and STEM students exhibit lower mental health literacy than students in other disciplines. Graduate Teaching Assistants (GTAs) play a crucial role in supporting undergraduate students, yet little is known about their mental health literacy (MHL) or how they navigate student disclosures in instructional settings. This preliminary study examines MHL among GTAs in biology, as well as their knowledge, perceptions, and training needs regarding MHL. We used semi-structured interviews and thematic analysis to examine how biology GTAs understand mental health, their responsibility related to student well-being, and what supports they identify …


Variation In Nectar Rewards Under Water Limitation Across Flowering Species, Madeline Isabelle Gregor Dec 2025

Variation In Nectar Rewards Under Water Limitation Across Flowering Species, Madeline Isabelle Gregor

Undergraduate Honors Theses

Drought is becoming an increasingly dominant force shaping plant–pollinator interactions, yet we still know little about how nectar rewards respond to water limitation across species commonly used to support pollinators. We examined nectar volume and sucrose content in six flowering species relevant to California’s Mediterranean climate and quantified how drought alters these traits for four of those species. Under well-watered conditions, species differed in their nectar production, spanning more than two orders of magnitude. Perennial species such as Epilobium canum and Scrophularia californica produced the highest nectar volumes and sucrose amounts, suggesting that they contribute substantial carbohydrate resources when moisture …


Effects Of Beach Renourishment On Sea Turtle Nesting Success, Caydence Pennington Dec 2025

Effects Of Beach Renourishment On Sea Turtle Nesting Success, Caydence Pennington

Honors Theses

Beach geomorphology has a profound influence on nesting animals, particularly sea turtles, whose reproductive success depends on suitable sand conditions and stable shorelines. In many densely populated coastal regions, beach renourishment projects are implemented to combat erosion and protect infrastructure, yet these alterations can also affect sea turtle nesting ecology. This study evaluated the effects of beach renourishment on loggerhead sea turtle (Caretta caretta) nesting activity on Longboat Key, Florida, from 2021-2024. Nesting activity, hatch success, and depredation patterns were compared between nourished and reference beach zones to determine whether nourishment had an impact on these events. Nesting …


Mitochondrial Calcium Uniporter Regulates Itam-Dependent Platelet Activation, Jehiel Abigail Ajanel Gomez Dec 2025

Mitochondrial Calcium Uniporter Regulates Itam-Dependent Platelet Activation, Jehiel Abigail Ajanel Gomez

Arts & Sciences Graduate Student Theses and Dissertations

Thromboembolic conditions are the leading cause of disability and death in the United States. Platelets play an important role in the pathophysiology of thrombus formation by aiding in the formation and stabilization of the clot. Central to platelet activation is cytoplasmic calcium, which increases after platelet activation through ITAM (Immunoreceptor tyrosine-based activation motif) or GPCR (G-protein-coupled receptor) receptors. Platelet mitochondria rely on cytoplasmic calcium for mitochondrial calcium influx, which is critical for ATP formation and regulation of mitochondrial reactive oxygen species. In other cells, mitochondrial calcium entry is regulated by the multimeric protein complex, mitochondrial calcium uniporter (MCU). Deletion of …


Understanding Outer Membrane Vesicle Biogenesis In Bacteroides Thetaiotaomicron, Evan J. Pardue Dec 2025

Understanding Outer Membrane Vesicle Biogenesis In Bacteroides Thetaiotaomicron, Evan J. Pardue

Arts & Sciences Graduate Student Theses and Dissertations

Outer membrane vesicles (OMVs) are small proteoliposomes generated by active protrusion of the outer membrane (OM) in Gram-negative bacteria during growth. Over 60 years of experimentation has ascribed numerous functions to OMVs produced by different bacteria. However, the mechanism(s) by which OMVs are produced is poorly understood. Due to this, the field remains controversial because many regard OMVs as byproducts of cell lysis and question their physiological relevance. Previous studies in Pseudomonas aeruginosa and related species confirmed that these microbes undergo programmed cell death that results in the stochastic release of vesicles and cellular contents. On the contrary, Bacteroides spp. …


Effect Of Nano Edible Coating, Storage Temperature, And Packaging On Water Content, Weight Loss, And Color On Oyster Mushrooms (Pleurotus Ostreatus), Inneke Amalia, Warid Ali Qosim, Kusumiyati Dec 2025

Effect Of Nano Edible Coating, Storage Temperature, And Packaging On Water Content, Weight Loss, And Color On Oyster Mushrooms (Pleurotus Ostreatus), Inneke Amalia, Warid Ali Qosim, Kusumiyati

Jurnal Kultivasi

Oyster mushrooms are one of the most commonly consumed mushrooms due to their high nutritional content, including protein, fiber, vitamins, and minerals, as well as their antioxidant properties. However, these mushrooms are easily damaged by microbes and poor post-harvest handling, which affects their quality. The combination of nano-edible coating, packaging, and storage temperature offers a solution to these issues. This study aims to evaluate the effects of nano-edible coating, packaging, and storage temperature on water content, weight loss, and the color (L*, a*, and b*) of oyster mushrooms. The study was conducted at the Horticulture Laboratory, Faculty of Agriculture, Universitas …


The Effects Of Nanobubble Fertigation And Soil Conditioners To Improve Nutrient Dynamics, Soil Microbial Activity, And Chili Productivity, Betty Natalie Fitriatin, Euis Ahah Rokayah, Elsa Naila Elmyra, Tualar Simarmata, Nicky Oktav Fauziah, Hanif Fakhrurroja Dec 2025

The Effects Of Nanobubble Fertigation And Soil Conditioners To Improve Nutrient Dynamics, Soil Microbial Activity, And Chili Productivity, Betty Natalie Fitriatin, Euis Ahah Rokayah, Elsa Naila Elmyra, Tualar Simarmata, Nicky Oktav Fauziah, Hanif Fakhrurroja

Jurnal Kultivasi

Drip fertigation is a fertilization method that integrates nutrient delivery with an irrigation system, which is capable of optimizing the direct delivery of nutrients to the root zone. This experiment aims to investigate the effect of drip fertigation with nanobubble technology, and soil conditioners on the population of Phosphate-Solubilizing Bacteria (PSB) and Azotobacter spp., available phosphorus, total nitrogen, growth, and yield of red chili. The study used a Strip Plot Design with two factors and three replications. The first factor was nutrient application (solid NPK fertilizing as control; drip fertigation; and drip fertigation with nanobubble technology), and the second factor …


Effects Of Integrated Biological And Chemical Fertilization On Pecco And Banji Shoot Development In Tea Plants, Intan Ratna Dewi Anjarsari, Muhammad Raihan Abdillah Farros, Santi Rosniawaty Dec 2025

Effects Of Integrated Biological And Chemical Fertilization On Pecco And Banji Shoot Development In Tea Plants, Intan Ratna Dewi Anjarsari, Muhammad Raihan Abdillah Farros, Santi Rosniawaty

Jurnal Kultivasi

Tea productivity and quality are largely determined by shoot structure, particularly the balance between pecco shoots (tender buds and young leaves) and banji shoots (older, less productive shoots). Conventional reliance on inorganic fertilizers often enhances overall growth but does not necessarily improve shoot structure, while biofertilizers alone provide limited nutrient availability. This study aimed to evaluate the effects of combining microbial-based liquid biofertilizers with inorganic fertilizers on the structure of tea shoots. The experiment was carried out on seed-derived tea plants using a randomized block design with several fertilization treatments, including sole biofertilizer, sole inorganic fertilizer, and their combinations. The …


Effects Of Beach Morphology On Nesting Behavior And Success Of Loggerhead Sea Turtles (Caretta Caretta) In South Carolina, Reagan Rutkowski Dec 2025

Effects Of Beach Morphology On Nesting Behavior And Success Of Loggerhead Sea Turtles (Caretta Caretta) In South Carolina, Reagan Rutkowski

Honors Theses

Loggerhead sea turtles (Caretta caretta) rely on sandy beach habitats for successful reproduction, yet nesting success is strongly influenced by physical beach features. This study examines the impact of beach morphology on nest survivorship across six nesting beaches in Horry and Georgetown counties, South Carolina. Three key hypotheses were tested: (1) nests placed at higher elevations exhibit greater survivorship, (2) nests located further from the recent high tide line experience higher survivorship, and (3) overall beach morphology influences nesting behavior and outcomes. Beach morphology variables—including elevation, slope, and nest-to-water distances—were measured at individual nest sites, while survivorship data …


Heat Increment Of Feeding In The Common Bottlenose Dolphin (Tursiops Truncatus) Contributes Moderately To Field Metabolic Rate Estimates, Ioulia Koliopoulou, Stacy L. De Ruiter, Jordi Altimiras, Josefin Larsson, Julietta Arenarez, David Rosen, Andreas Fahlman Dec 2025

Heat Increment Of Feeding In The Common Bottlenose Dolphin (Tursiops Truncatus) Contributes Moderately To Field Metabolic Rate Estimates, Ioulia Koliopoulou, Stacy L. De Ruiter, Jordi Altimiras, Josefin Larsson, Julietta Arenarez, David Rosen, Andreas Fahlman

University Faculty Publications and Creative Works

Digestion elevates metabolism through the heat increment of feeding (HIF) – the energy expended on mechanical and biochemical processes after eating. Quantifying this cost is essential for bioenergetic models that predict energy flow and prey requirements in populations. Using breath-by-breath respirometry, we measured oxygen consumption (V̇ O2 ) in eight common bottlenose dolphins (Tursiops truncatus) before and after feeding standardized meals (1659–2658 kcal of capelin and herring). Metabolic rate rose by ∼37% above resting levels, peaking 60 min after feeding before returning to baseline within 2 h. When scaled across the day, digestion increased daily metabolic needs by ∼8.2% of …


How The Intake Of Pulses May Impact Metabolic Disorders And Dementia Risk: A Narrative Review, Lisa Michelle Belzer Salinas, Maricarmen Marroquin, Mariana Mendez, Isabel Omaña-Guzmán, Juan Carlos López-Alvarenga Dec 2025

How The Intake Of Pulses May Impact Metabolic Disorders And Dementia Risk: A Narrative Review, Lisa Michelle Belzer Salinas, Maricarmen Marroquin, Mariana Mendez, Isabel Omaña-Guzmán, Juan Carlos López-Alvarenga

Health & Biomedical Sciences Faculty Publications

We present a narrative review focusing on pulses’ geographical origin and distribution, their impact on human evolution and history, and their influence on human health. Pulses, including dry peas, beans, and lentils, are renowned for their richness in chemical antioxidants. Despite containing antinutrients, processing techniques preserve their health advantages. Epidemiological research has consistently demonstrated that the consumption of pulses is associated with favorable effects on metabolism. This evidence is further supported by molecular and clinical research, which has elucidated potential nutrigenomic mechanisms and effects on gut microbiota composition underlying their health benefits. However, the literature lacks randomized controlled clinical trials …


Sex Disparities In Prescription Opioids Associated Cardiovascular Adverse Events, Li Ma Dec 2025

Sex Disparities In Prescription Opioids Associated Cardiovascular Adverse Events, Li Ma

Theses and Dissertations

The opioid crisis in the United States has evolved from a medical response to pain into a nationwide public health emergency. The prescription opioids (POs) – associated cardiovascular adverse events (CVAEs) remain insufficiently studied, especially in relation to sex disparities. This dissertation investigates sex disparities in PO-associated cardiovascular adverse events (CVAEs) through an analytic framework integrating artificial-intelligence-assisted literature mining and real-world pharmacovigilance analytics. In the analytic framework, first, AI powered topic modeling was employed to uncover POs-associated CVAEs risks with a focus on sex differences. A total of 1,837 PubMed abstracts were analyzed using two methods, Latent Dirichlet Allocation (LDA) …


The Cytotoxicity And Anti-Inflammatory Properties Of 1’S-1’-Acetoxychavicol Acetate (Aca) On Oral Cells, Nur Umairah Atiqah Sabri, Nor Syazwani Muhammad Zahidan, Zulfahmi Said, Siti Noor Adnalizawati Adnan, Normaliza Ab Malik Dec 2025

The Cytotoxicity And Anti-Inflammatory Properties Of 1’S-1’-Acetoxychavicol Acetate (Aca) On Oral Cells, Nur Umairah Atiqah Sabri, Nor Syazwani Muhammad Zahidan, Zulfahmi Said, Siti Noor Adnalizawati Adnan, Normaliza Ab Malik

Journal of Dentistry Indonesia

Objective: Mouthwash is widely used to maintain oral health by reducing the prevalence of pathogenic microbiomes. Nonetheless, chlorhexidine, a common active ingredient, is associated with side effects including teeth staining, mucosal peeling, mouth and tongue numbness. This has prompted interest in natural alternatives. This study aimed to identify the cytotoxicity and anti-inflammatory properties of 1’S-1’-acetoxychavicol acetate (ACA) isolated from Alpinia conchigera rhizome against human primary gingival fibroblast and keratinocyte (HPGF and HPGK). Methods: Cytotoxicity of ACA (1.57 mg/mL) against HPGF and HPGK was assessed using the MTT assay. Meanwhile, the anti-inflammatory property of ACA was analyzed based on …


Growth Of Porang (Amorphopallus Muelleri) Seedlings As Influenced By Seed Maturity And The Presence Of Sarcotesta, Indri Fariroh, Restiani Sih Harsanti, Aminatun Nisa, Didik Pudji Restanto, Rizky Anugerah Putra Dec 2025

Growth Of Porang (Amorphopallus Muelleri) Seedlings As Influenced By Seed Maturity And The Presence Of Sarcotesta, Indri Fariroh, Restiani Sih Harsanti, Aminatun Nisa, Didik Pudji Restanto, Rizky Anugerah Putra

Jurnal Kultivasi

Porang seed maturity based its position on spadix position significantly impacts germination. The presence of the seed coat (sarcotesta) also influenced germination and initial seedling growth. This study aimed to explore the effect of seed maturity and the presence of sarcotesta to the seedling growth. The experiment was conducted from January to June 2023. A two factor Randomized Complete Block Design was employed, examining three maturity levels based on spadix position (physiological maturity seed from the tip spadix (red colour), half physiological maturity seed from the middle spadix (orange colour), and immature seed from the base spadix (green colour)), and …


Production Analysis Of Seed-Derived Tea Plants (Camellia Sinensis (L.) O. Kuntze) Across Two Different Seasons, Nurlita Rahmawati, Yudithia Maxiselly, Intan Ratna Dewi Anjarsari, Heri Syahrian Khomaeni, Gerry Renaldi, Agung Karuniawan Dec 2025

Production Analysis Of Seed-Derived Tea Plants (Camellia Sinensis (L.) O. Kuntze) Across Two Different Seasons, Nurlita Rahmawati, Yudithia Maxiselly, Intan Ratna Dewi Anjarsari, Heri Syahrian Khomaeni, Gerry Renaldi, Agung Karuniawan

Jurnal Kultivasi

Tea (Camellia sinensis (L.) O. Kuntze) is a major economic crop in Indonesia, yet its productivity is strongly influenced by environmental variability, particularly rainfall seasonality. Fluctuating yields under dry and wet conditions pose challenges for sustainable tea production. This study aimed to assess the effects of contrasting seasonal rainfall on seed-derived tea plants' yield and yield components. The research was conducted at a seed-derived tea plantation block in IRITC, West Java, across dry and wet seasons using field observations on tea yield, shoot proliferation, plucking quality, and environmental parameters. Statistical analyses included independent t-tests to compare seasonal differences and Pearson …


Anexelekto (Axl)/Mer Inhibitor Tamnorzatinib In Patients With Relapsed/Refractory Acute Myeloid Leukaemia: Results From A Phase I (Monotherapy) And Phase Ii (Combination With Venetoclax) Clinical Study, Margaret T Kasner, Nigel Courtenay-Luck, Courtney Dinardo, Sean M Post, Praneeth Baratam, George N Magrath, Takaaki Nakamura, Akifumi Fujii, Sergio Prados, Naoki Honda, Mary Mcbride, Paula Edwards-Holmes, Robert Stuart Dec 2025

Anexelekto (Axl)/Mer Inhibitor Tamnorzatinib In Patients With Relapsed/Refractory Acute Myeloid Leukaemia: Results From A Phase I (Monotherapy) And Phase Ii (Combination With Venetoclax) Clinical Study, Margaret T Kasner, Nigel Courtenay-Luck, Courtney Dinardo, Sean M Post, Praneeth Baratam, George N Magrath, Takaaki Nakamura, Akifumi Fujii, Sergio Prados, Naoki Honda, Mary Mcbride, Paula Edwards-Holmes, Robert Stuart

Faculty, Staff and Student Publications

Introduction: Relapsed/refractory (R/R) acute myeloid leukaemia (AML) is a life-threatening haematological malignancy without effective treatments. Anexelekto (Axl) and Mer receptor tyrosine kinases have emerged as important therapeutic targets in AML for their crucial role in survival of AML cells. Tamnorzatinib (ONO-7475) is a potent and highly selective inhibitor of Axl/Mer. We report first-in-human study of tamnorzatinib (NCT03176277) in patients with R/R AML.

Methods: Tamnorzatinib was administered as monotherapy (n = 20) to determine an appropriate biological dose of tamnorzatinib and then in combination (n = 22) with venetoclax to evaluate safety and clinical efficacy.

Results: Tamnorzatinib was safe …


Stromal Fibroblastic Mutant Trp53 Promotes Mammary Tumor Development Via Enhanced Secretion Of Paracrine Factors, Bin Liu, Shunbin Xiong, Abie Williams-Villalobo, Gilda Chau, Yuan Qi, Hehua Chen, Carenza Johnson, Dhruv Chachad, Joy Mcdaniel, Xiaoping Su, Adel K El-Naggar, Guillermina Lozano, Yun Zhang Dec 2025

Stromal Fibroblastic Mutant Trp53 Promotes Mammary Tumor Development Via Enhanced Secretion Of Paracrine Factors, Bin Liu, Shunbin Xiong, Abie Williams-Villalobo, Gilda Chau, Yuan Qi, Hehua Chen, Carenza Johnson, Dhruv Chachad, Joy Mcdaniel, Xiaoping Su, Adel K El-Naggar, Guillermina Lozano, Yun Zhang

Faculty, Staff and Student Publications

Mutations in the tumor suppressor gene TP53 have been identified in breast cancer-associated fibroblasts and are associated with poor patient prognosis. However, the functional impact of fibroblastic mutant p53 on breast cancer development remains unclear. To investigate this, we compared female mice harboring HER2-driven mammary tumors with a fibroblast-specific Trp53 mutation (NP) to those with wild-type fibroblastic Trp53 (N). NP mice exhibited significantly shorter median tumor-free survival than N mice. RNA sequencing of NP and N tumors and mammary glands revealed numerous differentially expressed genes (DEGs) between tumors and the corresponding glands in both genotypes. Notably, the NP tumors showed …


Measurable Imaging-Based Changes In Enhancement Of Intrahepatic Cholangiocarcinoma After Radiotherapy Reflect Physical Mechanisms Of Response, Brian De, Prashant Dogra, Mohamed Zaid, Dalia Elganainy, Kevin Sun, Ahmed M Amer, Charles Wang, Michael K Rooney, Enoch Chang, Hyunseon C Kang, Zhihui Wang, Priya Bhosale, Bruno C Odisio, Timothy E Newhook, Ching-Wei D Tzeng, Hop S Tran Cao, Yun S Chun, Jean-Nicholas Vauthey, Sunyoung S Lee, Ahmed Kaseb, Kanwal Raghav, Milind Javle, Bruce D Minsky, Sonal S Noticewala, Emma B Holliday, Grace L Smith, Albert C Koong, Prajnan Das, Vittorio Cristini, Ethan B Ludmir, Eugene J Koay Dec 2025

Measurable Imaging-Based Changes In Enhancement Of Intrahepatic Cholangiocarcinoma After Radiotherapy Reflect Physical Mechanisms Of Response, Brian De, Prashant Dogra, Mohamed Zaid, Dalia Elganainy, Kevin Sun, Ahmed M Amer, Charles Wang, Michael K Rooney, Enoch Chang, Hyunseon C Kang, Zhihui Wang, Priya Bhosale, Bruno C Odisio, Timothy E Newhook, Ching-Wei D Tzeng, Hop S Tran Cao, Yun S Chun, Jean-Nicholas Vauthey, Sunyoung S Lee, Ahmed Kaseb, Kanwal Raghav, Milind Javle, Bruce D Minsky, Sonal S Noticewala, Emma B Holliday, Grace L Smith, Albert C Koong, Prajnan Das, Vittorio Cristini, Ethan B Ludmir, Eugene J Koay

Faculty, Staff and Student Publications

Escalated doses of radiotherapy associate with improved local control and overall survival (OS) in intrahepatic cholangiocarcinoma (iCCA), but personalization remains limited because conventional size-based CT criteria correlate poorly with outcomes. We hypothesized that quantitative enhancement measurements would better predict clinical outcomes and guide individualized RT optimization. In a retrospective cohort of 154 patients, we analyzed pre- and post-RT CT scans using quantitative European Association for Study of Liver (qEASL) to derive viable tumor volumes, comparing enhancement-based metrics with size-based RECIST and linking them to outcomes via survival and mathematical modeling. Change in enhancement volume was strongly associated with OS after …


The Biology Of Green Antelopehorn Milkweed (Asclepias Viridis Walter) And Hemp Dogbane (Apocynum Cannabinum L.) And Response To Triclopyr Formulations And Other Auxin Herbicides, Kayla L. Broster Dec 2025

The Biology Of Green Antelopehorn Milkweed (Asclepias Viridis Walter) And Hemp Dogbane (Apocynum Cannabinum L.) And Response To Triclopyr Formulations And Other Auxin Herbicides, Kayla L. Broster

Theses and Dissertations

Studies were conducted in Oktibbeha and Clay Counties in Mississippi to determine the response of green antelopehorn milkweed and hemp dogbane to triclopyr and other auxin herbicides in non-cropland areas. These studies were conducted at four locations with well established populations for each species throughout 2020 to 2023, with applications repeated at each location the following year if populations persisted. Treatments included a high and low rate of each herbicide studied, with all four triclopyr formulations included for both species. Injury response data were collected two and four weeks after treatment and population density data were evaluated using individual stem …


Trace Mineral Supplementation Strategies For Beef Cattle During Preconditioning And Feedlot Receiving, Madeline G. Mcknight Dec 2025

Trace Mineral Supplementation Strategies For Beef Cattle During Preconditioning And Feedlot Receiving, Madeline G. Mcknight

Theses and Dissertations

Beef cattle routinely undergo a variety of stressors within the preconditioning and feedlot receiving phases which may impair animal performance and health. Trace mineral supplementation, either through dietary or injectable sources, is proposed to mitigate these effects through metabolic and immune system support. Two systematic reviews and meta-analyses were conducted to evaluate the efficacy of two different oral supplementation methods, organic (OTM) and inorganic (INR), and injectable trace mineral (ITM) solutions on average daily gain (ADG) and morbidity. Across 20 studies, OTM supplementation increased ADG (P = 0.01) when compared to INR, but did not affect morbidity (P = 0.92). …


Spatiotemporal Ecology Of Mycobacterium Ulcerans And Mycolactone Functions In French Guiana And Southeastern United States Aquatic Environments, Magdalene Dogbe Dec 2025

Spatiotemporal Ecology Of Mycobacterium Ulcerans And Mycolactone Functions In French Guiana And Southeastern United States Aquatic Environments, Magdalene Dogbe

Theses and Dissertations

Mycobacterium ulcerans, the causative agent of Buruli ulcer, produces mycolactone, a polyketide toxin traditionally studied for its role in human pathogenesis. This dissertation presents a comprehensive spatiotemporal analysis of M. ulcerans and mycolactone producing mycobacteria (MPM) ecology in the Americas and also reveals mycolactone's role in the environment as a microbial community regulator. Through comparative studies in French Guiana (endemic) and the southeastern United States (non-endemic), combined with experimental microcosm investigations, this research contributes to environmental pathogen ecology understanding. Environmental surveillance across 2,226 samples from French Guiana revealed complete MPM restriction to freshwater environments, with zero detections from 1,226 coastal …


Genomics Insights Into The Biogeography And Evolution Of Galapagos Iguanas Using Radseq And Wgseq Techniques, Cecilia Paradiso Dec 2025

Genomics Insights Into The Biogeography And Evolution Of Galapagos Iguanas Using Radseq And Wgseq Techniques, Cecilia Paradiso

Theses and Dissertations

The Galápagos archipelago is known for its unique endemic fauna shaped by isolation and geological dynamism. This thesis explores the evolutionary history of Galápagos iguanas, a monophyletic group comprising the marine iguana (Amblyrhynchus cristatus) and three land iguanas: Conolophus marthae, C. pallidus, and C. subcristatus. These species differ in distribu- tion, population size, and conservation status, with C. marthae classified as Critically Endan- gered due to its restricted range and small population. The main goal of this thesis is to fill knowledge gaps concerning the evolutionary trajectories, demographic histories, and genetic var- iability of Galápagos iguanas. The first chapter reconstructs …


Study Of Insect Frass-Associated Microbiome On Plant Growth And Their Potential Use As Biofertilizer, Jasmine Sahota Dec 2025

Study Of Insect Frass-Associated Microbiome On Plant Growth And Their Potential Use As Biofertilizer, Jasmine Sahota

Theses and Dissertations

An increasing global food demand and the urgent need for sustainable agricultural practices have driven interest in insects as alternative feed and food sources. Insect frass, a by-product of insect rearing, represents a rich organic carbon source with diverse microbes that can enhance soil health and promote beneficial plant-microbe interactions. This study characterized the bacterial (16S-V4) and fungal (ITS2) microbiomes of frass from Black Soldier Fly (BSF) and Cricket species and evaluated their effects on maize (Zea mays) growth. Four frass variants were applied at rates of 56-280 kg ha⁻¹ in a pot experiment with untreated soil and mineral fertilizer …