Digital Commons Network^™

Identifying Sorafenib Benefit Among Patients With Hepatocellular Carcinoma: A Transcriptomic And Genomic Approach, Sun Young Yim, Hayeon Kim, Tae Hyung Kim, Sang-Hee Kang, Youngwoo Lee, Eunho Choi, Yang Jae Yoo, Seong Hee Kang, Young-Sun Lee, Young Kul Jung, Yeon Seok Seo, Hyung Joon Yim, Jong Eun Yeon, Kyung Suk Yang, Yitao Tang, Bowha Sohn, Yun Seong Jeong, Hyewon Park, Han Liang, Ju-Seog Lee, Ji Hoon Kim

Faculty, Staff and Student Publications

Background & aims: Sorafenib has been a cornerstone of hepatocellular carcinoma (HCC) therapy; however, its efficacy is limited, and identifying patients who will benefit from sorafenib is challenging. We aimed to identify predictive biomarkers of sorafenib benefit in patients with HCC.

Methods: Gene expression data from 33 HCC tumors treated with sorafenib were analyzed to construct a prediction model aimed at identifying patients with greater benefit from sorafenib treatment. The robustness of the predictor was validated using gene expression data from two phase III clinical trials, IMbrave150 and STORM.

Results: The analysis of transcriptome data revealed a 50-gene signature, the …

Variable Hybridization Rates Between F2 Fundulus Notatus Females, Jordan Tanaka

Honors Theses

Hybridization between two related species has been widely observed and offers a lens into complex evolutionary processes. Endogenous and exogenous factors affect hybrid fitness and diversification, and pre-zygotic and post-zygotic barriers affect species’ ability to hybridize. Female mate choice is a pre-zygotic isolation mechanism which is known to be more significant than male mate choice in many species, a trend which is linked to females often investing more energy into offspring. Detailing the ways in which these mechanisms operate is integral to understanding hybridization on a larger scale. The species examined here, Fundulus notatus and Fundulus olivaceous, are closely …

Just Unmasking Knowledge? A Critical Interpretation Of Fluctuating Jellyfish Populations For A Mass Media Audience, Wrenne R. Grone

Undergraduate Honors Thesis Projects

While podcasts may not be the most popular form of mass media, they are growing in their accessibility and prevalence in educational discourse. My creative work, in the form of a podcast, unmasks scientific knowledge in an untraditional, mass-media form and will use podcast techniques, such as music transitions and storytelling techniques, to maintain engagement. Additionally, my podcast aims to transpose academic knowledge into a comprehensible, interesting form for a non-academic audience. Jellyfish have no brains, no heart, no blood, and no bones and yet, they have survived for millions of years. The goal of my podcast is to educate …

Axillary Management After Neoadjuvant Endocrine Therapy (Net), Laura Leonard, Min Yi, Emma Wingate, Puneet Singh, Abigail Caudle, Rosa F Hwang, Isabelle Bedrosian, Vicente Valero, Jennifer Litton, Nuhad Ibrahim, Kelly K Hunt

Faculty, Staff and Student Publications

BACKGROUND: In patients with hormone receptor-positive (HR

PATIENTS AND METHODS: We performed a retrospective review of patients with clinical stage I-III, HR

RESULTS: A total of 230 patients were included; 120 (52.2%) were clinically node-negative (cN0), while 110 (47.8%) were clinically node-positive (cN+). In the cN+ group, 7.3% (8/110) had a nodal pathologic complete response (pCR). In total, 76.4% (84/110) in the cN+ group underwent axillary lymph node dissection (ALND) as the initial axillary procedure, and 90.9% (100/110) underwent ALND overall. In total, 98.3% (118/120) with cN0 disease underwent sentinel lymph node dissection (SLND), and 28 (23.7%) had positive nodes. …

Polyhydroxybutyrate (Phb) From Biofloc Systems Enhances The Growth And Immune Performance Of Genetically Improved Farmed Tilapia, Menaga Meenakshisundaram, Jimmy B. Mboya, Felix Sugantham

All Peer-Reviewed Publications

This study characterised polyhydroxybutyrate (PHB)-producing bacteria from the culture water of genetically improved farmed tilapia (GIFT) in biofloc ponds and investigated the influence of PHB on the growth and immune performance of GIFT. Out of 40 bacterial isolates, Bacillus infantis, Exiguobacterium profundum, Bacillus subtilis, Bacillus megaterium, Klebsiella pneumoniae and Enterococcus hirae showed positive results for PHB against fluorescent stains. The PHB yield in the range of 5%–95.45% (w/w) was recorded, with the highest from K. pneumoniae (95.45% w/w). The experimental treatments included a basal diet as a control (C), a basal diet with PHB (5 g kg⁻¹) from …

Agronomic Practices For Climate-Resilient Okra Production In Agroecological Systems: A Review, Samuel Mathu Ndungu, Lokeshwar Kesamreddy, Mathieu A.T. Ayenan, Stephen Othim, Siyabusa Mkuhlani, Yu Hsiang Liu, Amha Besufkad, Wubetu Bihon Legesse, Eric C. Legba, Judith Honfoga, Lukas Pawera

All Peer-Reviewed Publications

Okra is increasingly recognized as a climate-resilient crop within diversified agroecological systems; however, an integrated synthesis of its biophysical, agronomic, and socioeconomic dimensions is lacking. This review consolidates the current knowledge on okra physiology, production ecology, and value chains, with a focus on climate resilience under heat, drought, salinity, pest, and disease pressures. Evidence across regions demonstrates that agroecological practices such as crop diversification, mulching, conservation tillage, integrated pest management, and the use of organic and biological inputs consistently improve soil health, stabilize yields under climatic stress, and reduce dependence on external inputs, although with trade-offs in labor demand and …

A Double-Edged Sword? Liana Wood Decomposes Faster Than Tree Wood, Denis Mburu Njoroge, Aphrodis Munyaneza, Juan Zuo, Gbadamassi G. O. Dossa, Douglas Schaefer, Rhett D. Harrison, Stefan A. Schnitzer, J. Hans C. Cornelissen

Biological Sciences Faculty Research and Publications

Lianas are increasing in many forests and show higher stem turnover rates and different chemical profiles compared with trees. However, liana deadwood decomposition dynamics have been overlooked. We redress this omission and hypothesize that liana wood decomposes faster than tree wood due to its larger vessels and higher nutrient content than trees, resulting in greater activity of both microbial and invertebrate decomposers. We tested this hypothesis in a common-garden decomposition experiment with deadwood of two size classes (2.5 and 4 cm diameter) belonging to 12 liana and 12 tree species in tropical China. Liana wood decomposed 28.6% faster than tree …

Global Epidemiology Of Cephalopina Titillator Infestation In Camels: A Systematic Review And Meta-Analysis (1980–2025), Temesgen Mohammed, Aboma Zewude, Tsegaye Shamebo, Layaly Hamdan, Atef Oreiby, Hazim O. Khalifa, Gobena Ameni, Bojan Gajic

All Works

Background – Cephalopina titillator (C. titillator) is the causative agent of camel nasopharyngeal myiasis and is widespread in camel-rearing regions worldwide, causing impaired health, reduced productivity, and economic losses. However, despite the veterinary importance of C. titillator, global epidemiological evidence remains limited and fragmented, and no comprehensive synthesis of prevalence data across camel-rearing regions has previously been conducted. The objective of this review was to estimate the global pooled prevalence of C. titillator infestation in camels. In addition, subgroup analyses were made to assess the effect of camel species, geographic region, and study period on the pooled prevalence of C. …

Quantifying Nutrient Fluxes Across The Sediment-Water Interface In The Lafayette River Estuary, Adriana E. Amrhein

OES Theses and Dissertations

The Lafayette River, a shallow, eutrophic tributary of the Chesapeake Bay, experiences seasonal harmful algal blooms (HABs). While management efforts focus on reducing external nutrient inputs, internal loading from benthic sediments remains poorly constrained. This study quantifies spatial and seasonal variability in nutrient and radium isotope fluxes across the sediment–water interface at three sites where HABs are known to initiate and represent contrasting sediment textures and hydrodynamic conditions. Sediment cores and porewater samples were collected in summer 2023 and winter 2024 to measure grain size, porosity, dissolved nutrients (NH₄⁺, NOₓ⁻, PO₄³⁻), and radionuclide activities (²²⁴Ra and ²²⁸Th). Radium isotope disequilibrium …

Lactation-Stage Specific Protein Shifts In Koala Milk Mirror The Joey's Growth Needs, Manujaya W. Jayamanna Mohottige, Angéla Juhász, Emma Peel, Mitchell G. Nye-Wood, Katherine A. Farquharson, Tawfeek Khedr, Katherine Belov, Carolyn J. Hogg, Michelle L. Colgrave

Research outputs 2022 to 2026

AbstractKoalas (Phascolarctos cinereus) give birth to highly altricial young that rely on maternal milk for nutritional support and immune protection in the first year of life. This study applied proteomics to analyse stage-specific shifts in the koala milk proteome across early-, mid-, and late-lactation. Proteins were extracted from seven samples and analysed using liquid chromatography-tandem mass spectrometry. Quantitative profiling identified 874, 1220, and 498 proteins in early-, mid- and late-lactation stages, respectively. The most abundant proteins—including β-lactoglobulin, caseins, clusterin, trichosurin, albumin and lactotransferrin—were consistently detected across all stages, reflecting crucial roles in nutrition, immune function, and detoxification. Protein–protein interaction analyses …

Optimizing Duckweeds Harvesting Strategies To Maximize Nutrient Recovery And Its Role As A Phytosensor In Different Water Sources While Maintaining Sustainable Biomass Growth, Basma Ghannam

Theses

This thesis is concerned with determining the optimal water treatment and harvesting strategy for Lemna minor duckweed plants. The main objective of this thesis is to examine how duckweed plants grow in terms of biomass, photosynthetic activity, leaf morphology, chlorophyll and carotenoid content, and their efficiency in nutrient removal from different water sources. The methodology of the study included assessing duckweed in three water samples including tap water, saline water, and greywater and three harvesting strategies, including low, medium, and high harvesting intensities to assess their growth and nutrient removal efficiency. The results of the study showed that L. minor …

Comparative Evaluation Of Five Bacterial Strains For The Fermentation Of Camel Milk, Sifatun Nesa Ali

Theses

In this study, the comparative fermentation performance of lactic acid bacteria Streptococcus thermophilus, Lactobacillus delbrueckii subsp. bulgaricus, Lb. helveticus, Lb. casei, and Lactiplantibacillus plantarum in Camel Milk (CM) and Bovine Milk (BM) was investigated. Fermentations were carried out at 42°C for 48 hours, and was monitored through bacterial growth, titratable acidity, pH evolution, proteolytic activity, microstructural properties, and rheological characteristics. Although comparable bacterial viability was observed in CM and BM, acidification kinetics varied significantly between CM and BM (p < 0.05). Proteolysis was significantly higher in fermented CM than in BM (p < 0.001), with consistently greater o-Phthalaldehyde Assay (OPA) values in CM across all strains during fermentation (p < 0.001). Scanning electron microscopy revealed more porous, loose protein matrices in fermented CM than in BM, which supports the rheological results showing weaker gel networks and lower rheological strength in fermented CM. Among the tested bacteria, Lb. casei demonstrated superior adaptability, enhanced viability, balanced acidification, and favorable rheological properties in both milks. Overall, the results of this thesis demonstrate strain-specific fermentation responses and support the possible suitability of different starter cultures for improving the technological performance of fermented camel milk products.

Recombinant Gelonin: Purification And Functional Validation For Electroporation-Assisted Delivery, Eleni Zivla, Giedrė Šilkūnienė, Andrei G. Pakhomov, Mantas Šilkūnas, Olga N. Pakhomova

Knowledge and Creativity Expo

Type I ribosome-inactivating proteins, such as gelonin, are enzymatically potent toxins but are effectively non-toxic under physiological conditions because they are unable to cross the plasma membrane[1]. Pulsed electric fields (PEF) overcome this delivery barrier by transiently permeabilizing the plasma membrane, allowing direct cytosolic entry. This enhances gelonin cytotoxicity by several thousand-fold, highlighting gelonin’s potential as an electrochemotherapy candidate[2]. Here, we present a recombinant gelonin (rGel) expression platform in E. coli with HPLC-based purification that enables reproducible protein production and structure-guided engineering.

The mature gelonin sequence (residues 47–297) was cloned into pET-32a(+) with an N-terminally fused Trx-6×His tag and TEV …

Metabolomics In Precision Medicine: Application And Prospect In Cancer Research, Ming-Shi Shiao

Journal of Food and Drug Analysis

Metabolomics is the most recent and final discipline among the post-genomic, multiomics fields. It encompasses key technologies in systems biology, providing an overview of low-molecular-weight metabolites while examining disturbances to offer pathophysiological explanations. The two key analytical tools in metabolomics are nuclear magnetic resonance spectroscopy and mass spectrometry, which includes gas chromatography-mass spectrometry and liquid chromatography-mass spectrometry. Metabolomic research relies on a three-stage data generation process: the first stage involves precise analytical chemistry to produce data; the second stage employs multivariate statistical analysis; and the last stage uses big data as a reference for comparison to establish biochemical, metabolic, and …

Mass Spectrometry-Based Metabolomics For Studying Gut Microbiota-Derived Metabolites In Biological Samples, Ya-Ting Lin, Huai-Hsuan Chiu, Chih-Ning Cheng, Ching-Hua Kuo

Journal of Food and Drug Analysis

Gut microbiota produces a wide range of metabolites and plays a critical role in maintaining host health. Dysregulation of these metabolites can influence host metabolism through systemic circulation, contributing to the development of various diseases, including immunological, neurological and cancer-related disorders. Chromatography coupled with mass spectrometry (MS) has emerged as a powerful analytical approach, offering high sensitivity and resolution for studying gut microbiota-related metabolites. This review provides a comprehensive overview of chromatographic MS-based methods applied to the study of the gut microbial metabolome. We summarize strategies for sample collection, storage, and preparation of commonly analyzed sample types, including feces, plasma/serum, …

Special Issue: Analytical Technologies In Metabolomics: Applications And Future Prospects, Sung-Fang Chen

Journal of Food and Drug Analysis

No abstract for this article type.

Perspective In Biomedical Sciences Field: Education And Career, Fitra Adi Prayogo, Mellyaning Oktaviani Sonya Kirana Sari, Isy Royhanaty, Poppy Fansisca Amelia, Heni Wijayanti, Ni Nyoman Maryaningtyas Adinatha, Dyah Wulandari, Anto Budiharjo

Chulalongkorn Medical Journal

Abstract

Background: The biomedical sciences represent a dynamic and multidisciplinary field pivotal to advancing human health through research, education, and innovation.

Objective(s): This review explores the evolving landscape of biomedical education and career pathways, driven by technological advancements, interdisciplinary integration, and global health demands.

Methods: We examine the distinctions between biomedical science, biomedicine, and biomedical engineering, highlighting their historical origins and contemporary roles. The education and career trajectories of biomedical laboratory scientists (BLS) are analysed, emphasising diverse competencies, core curricula, and the impact of regional policies on professional qualifications. Emerging trends and ethical/regulatory challenges are discussed.

Result(s): Key trends include …

Risk Factors Of Leptospirosis Among Agricultural Workers In Southeast Asia: Literature Review, Ronggo Adi Wibowo, Wawa Najwa Nurzakia, Meirany Sasitha Kirana, Yulia Arthemisia Wijaya, Jasmine Ayumaharani Sekaryudha, Dwi Sarwani Sri Rejeki, Rosita Dwi Jayanti

Jurnal Epidemiologi Kesehatan Indonesia

The agricultural sector is the primary source of livelihood for communities in Southeast Asia; however, these activities increase the risk of exposure to zoonotic diseases, particularly leptospirosis. Southeast Asia is one of the regions with the highest incidence of leptospirosis in the world. This literature review aims to identify risk factors for leptospirosis among agricultural workers in Southeast Asia. The search for research articles utilized three databases (Google Scholar, PubMed, and ScienceDirect) using a descriptive approach based on literature review and the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. A total of 9,800 articles were screened for …

Factors Associated With Stunting Among Children Aged 6 – 59 Months Attending Integrated Health Post (Posyandu) In Selapajang And Kedaung Wetan Villages, Neglasari Sub-District, Tangerang City: A Matched Case-Control Study, Michael Alexander Solang, Joue Abraham Trixie, Gloria Semula, Tiona Simamora, Conny Tanjung

Jurnal Epidemiologi Kesehatan Indonesia

Stunting is a problem in Indonesia. In 2022, Kedaung Wetan and Selapajang Villages in Neglasari sub-district, Tangerang City, were identified as a priority. This study aimed to identify factors associated with stunting among children (6 – 59 months) in these villages. A matched case-control study consisting of 214 children (107 cases and 107 controls) was conducted, with individual matching based on age, sex, and prematurity at birth. Cases were children with height-for-age (H/A) measurement less than -2SD (according to WHO standard), while controls were children with H/A equal to or greater than -2SD. Conditional logistic regression was used for the …

What Is Alive? Students’ Conceptions Of The Traits That Unite Living Organisms, Jeremy L. Hsu, Meredith A. Dorner, Kate Hill

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

Biology is the study of life, but students often hold misconceptions about what it means to be alive, with children often associating life with movement. These misconceptions can lead to biases in what students think is alive, with younger children often not thinking of plants as living given their lack of discernable movement. Despite this past work, there have been no prior studies that we are aware of that have examined how students in introductory biology conceptualize what it means to be alive. Here, we draw upon a fortuitous dataset collected from an in-class activity done on the first day …

Optimal Control And Bifurcation Analysis Of A Predator–Prey Model With Self-Limiting Growth And Predator Disease, Dipo Aldila, Muhammad Akmal Fasya, Bevina D. Handari, Chidozie Williams Chukwu, Olumuyiwa James Peter

Mathematical Modelling and Numerical Simulation with Applications

We propose and analyze an eco-epidemiological predator–prey model that incorporates self-limitation and disease transmission within the predator population. The model is formulated as a system of ordinary differential equations describing logistic prey growth under the interspecific interaction with the predator. On the other hand, the predator population is divided into susceptible and infected classes, whose growth is constrained by prey availability. Three biologically relevant equilibria are identified: predator extinction, disease-free coexistence, and coexistence with endemic disease. The existence and stability of these equilibria are determined by key ecological and epidemiological thresholds, including the basic reproduction number. Using numerical continuation methods, …

Optimal Control Strategies For Infectious Diseases: A Numerical Simulation Approach, M. Abu Salek, Jannatun Nayeem, Romana Yesmin, M. Haider Ali Biswas, M. Humayun Kabir

Mathematical Modelling and Numerical Simulation with Applications

Various infectious diseases, such as Tuberculosis and Hepatitis B virus (HBV), caused by Mycobacterium bacteria and hepatitis B virus, respectively, pose serious threats worldwide. This paper examines the spread of these diseases using a mathematical model that incorporates control measures, including vaccination and awareness programs. We use a system of differential equations with control variables and apply Pontryagin's principle to determine optimal control strategies. The stability of the Disease Free Equilibrium (DFE) has been analysed and demonstrated to be both locally and globally asymptotically stable when the basic reproduction number remains below unity, thereby ensuring disease elimination. Furthermore, the Endemic …

Numerical Simulations And Hyers-Ulam Stability Of A Novel Nonlocal Anthropogenic Cutaneous Leishmaniasis Mathematical Model, Khalid Fanoukh Al Oweidi, Zakirullah -, Kamal Shah, Thabet Abdeljawad

Mathematical Modelling and Numerical Simulation with Applications

In this work, the fractal-fractional Atangana-Baleanu derivative with the Mittag-Leffler kernel is employed to capture the memory and hereditary effects inherent to anthropogenic cutaneous leishmaniasis transmission dynamics. The Banach fixed-point theorem and contraction mapping principle are used to prove the existence and uniqueness of solutions, while Hyers-Ulam stability of the system is analyzed to demonstrate the robustness of solutions with respect to small perturbations. Using a nonlinear least-squares approach, model parameters and fractional order are estimated using epidemiological data from the World Health Organization. The basic reproduction number $R_0 = 0.53$ indicates that the disease is under control after adding …

Dynamical Analysis And Optimal Control Of The Mpox Transmission Model With Stratified Susceptibility, Tuhfatul Janan, Fatmawati Fatmawati, Cicik Alfiniyah, Santi Martini, Dipo Aldila, Agus Hasan

Mathematical Modelling and Numerical Simulation with Applications

This study develops a mathematical model of Mpox transmission that combines stratified susceptibility (low-risk and high-risk groups) with vaccinated and asymptomatically infected compartments. The analysis of the model begins with examining the well-posedness, boundedness, and nonnegativity conditions for the solutions. The local stabilities of the equilibria are examined through the Jacobian matrix and phase plane analysis, while the global stabilities are provided through Lyapunov functions. The estimated parameters are verified using epidemiological data on Mpox cases in the United States, with an MAPE of 2.20% and R_0 > 1, indicating that Mpox remains endemic. Sensitivity analysis indicates that the contact rate …

Regulation Of Zygotic Genome Activation By The Nucleocytoplasmic Ratio, Lily Acker, Hui Chen

Faculty Publications

During early development, embryos undergo the maternal-to-zygotic transition (MZT), when control of development shifts from maternal factors to the newly activated zygotic genome. Decades of studies in various model organisms suggest that the nucleocytoplasmic (N/C) ratio is a key regulator of zygotic genome activation (ZGA), though this relationship is more nuanced in some organisms than others. Changing the nuclear content, nucleus size or cell size has been shown to shift the timing of ZGA. Mechanistically, the N/C ratio is linked to fundamental cellular processes that regulate genome activities, including nuclear import, repressor titration, activator accumulation, cell cycle lengthening, and chromatin …

A Randomized Study Of Digital Versus Genetic Counselor Return Of Actionable Genetic Research Results To Biobank Participants (Respect3 Study), Anuja Rajendra Godbole, Elisabeth Wood, Brian Egleston, Lily Hoffman-Andrews, Sarah Brown, Sarah Howe, Sanjana Shastri, Rajia Mim, Justin Feng, Anjali Owens, Susan Domchek, Reed Pyeritz, Bryson Katona, Staci Kallish, Giorgio Sirugo, Joellen Weaver, Linda Fleisher, Kuang-Yi Wen, Elena Elkin, Katherine Nathanson, Daniel Rader, Angela Bradbury

Department of Medical Oncology Faculty Papers

BACKGROUND: There is consensus that research participants should be informed about plans for return of genetic research results. However, best practices for return of results in large biobank and cohort studies do not exist currently, and how best to communicate actionable genetic research results remains unclear. While having genetic counselors disclose these results may be ideal to ensure understanding, minimize distress, and optimize medical follow-up, genetic counselor (GC) workforce shortages and costs are barriers. The RESPECT3 study evaluates whether digital delivery alternatives for pre-disclosure education and return of actionable genetic research results is non-inferior to remote telehealth disclosure by a …

Prescribed Aerobic Exercise And Sport-Related Concussion Recovery: A Validation Case Series, Lacy L. Chapel, Tamara C. Valovich Mcleod

Clinical Practice in Athletic Training

Active rehabilitation, including prescribed sub-symptom threshold aerobic exercise implemented during the acute phase of recovery after sport-related concussion, has been shown to facilitate recovery and reduce the risk of persisting postconcussion symptoms. The purpose of this validation case series was to evaluate currently available external evidence regarding the effects of prescribed aerobic exercise interventions on recovery after sport-related concussion. For this study, the patient population included college athletes diagnosed with a sport-related concussion who participated in at least 5 days per week of supervised, prescribed aerobic exercise, based on graded aerobic exercise testing and heart rate threshold. Our study findings …

Evaluating Forearm Strength Variability In Collegiate Tennis Players Over The Course Of A Competitive Season, Jeffrey Williams, Payton Jensen, Kevin Laudner

Clinical Practice in Athletic Training

The muscles of the forearm undergo routine, forceful, and repetitive contractions while playing tennis and may experience adaptive changes that can precede injury. An understanding of forearm strength profiles of tennis players following a competitive season would assist clinicians’ evidence-based management of the forearm’s readiness for training, competition, and return-to-sport participation. Therefore, the purpose of this study was to explore the effects of a competitive tennis season on forearm strength among collegiate tennis athletes. A prospective, case-series design was used to examine a convenience sample of 15 asymptomatic NCAA Division I tennis players (males = 10, height = 182.88 [SD …

Quality Of Athletic Training Services For Lower Extremity Injuries, Katie Sniffen, Michael Rozier, Katherine Stamatakis, Paula Buchanan, Janet E. Simon, Leslie Hinyard

Clinical Practice in Athletic Training

The use of patient-reported outcomes in athletic training is inconsistent, limiting the ability to communicate service quality and value to key stakeholders. The objective of this study is to calculate meaningful quality outcome measures for athletic training services for lower extremity injuries in high school student-athletes. Data were collected from a subset of the National Athletic Treatment, Injury and Outcomes Network Surveillance Program and a convenience sample of high school student-athletes with patient-reported outcome measures for lower extremity time-loss injuries. Failure-toprogress proportions (FTPPs) were calculated using the Knee Injury and Osteoarthritis Outcome Score (KOOS) for knee/thigh injuries and the Foot …

Recurrent Urinary Tract Infections In An Elite Level Diver: A Disablement Model Case Study, Matt O'Sullivan, Dominique M. Stevens, Lindsey E. Eberman

Clinical Practice in Athletic Training

This article presents a case of complicated and recurrent pyelonephritis, an infection of 1 or both kidneys, in an elitelevel diver. Urinary tract infections (UTIs) are among the most common outpatient infections in the United States; most are uncomplicated and resolve without significant mortality or morbidity. However, UTIs have the potential to present significant clinical challenges if the UTI becomes complicated or recurrent. Additionally, recurrent UTIs can carry a significant burden to both the individual patients and the larger healthcare system. The current paper reviews the epidemiological literature surrounding UTIs, the significant impact they have on a patient’s health-related quality …