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Guide To The Crawford-Beck Vineyard Collection, Linfield University Archives

Linfield Archives Finding Aids

In 2005, David Beck and Jeanne Crawford purchased Casa-Blanca Vineyard and renamed it as Crawford-Beck Vineyard and owned it for 17 years. This collection focuses on the evolution of Crawford-Beck Vineyards from 2005 to 2023. It contains multiple business documents and records, such as expansion plans, invoices, and LIVE evaluation records. The collection also explores the personal growth and achievements of David and Jeanne Beck, the owners of Craw-Beck Vineyard. This includes their enrollment at Chemeketa Community College, their involvement in the wine industry in Oregon, and their personal assortment of books and articles. The collection also contains material outside …

Coming Soon To A Cellar Near You: Novel Range Expansion Of A Short-Bodied Cellar Spider, Physocyclus Enaulus (Araneae: Pholcidae), In A Building In Central Illinois, Usa, Ricky Gieser, Mark Davis

The Great Lakes Entomologist

A reproductive population of Physocyclus enaulus Crosby, 1926 (Pholcidae: Araneae), a short-bodied cellar spider native to the American southwest and Mexico, is documented for the first time in a single building in Illinois, far outside of their known native range. The means of introduction is unknown but is likely influenced by either accidental hitchhiking spiders or a deliberate introduction to control brown recluse populations. Cellar spiders were purchased and released in the same building to predate on brown recluse spiders, but the first P. enaulus individual was found a year prior to the release. These cellar spiders have a wide-ranging …

New Wisconsin State Records For Predatory Fungus Gnats (Diptera: Bibionomorpha: Keroplatidae), Daniel K. Young

The Great Lakes Entomologist

In Wisconsin, no published literature species records for the keroplatid genera Keroplatus and Proceroplatus exist (Diptera: Bibionomorpha: Keroplatidae). New state records are presented for Keroplatus carbonarius Bosc, Keroplatus clausus Coquillett, Keroplatus militaris Johannsen and Proceroplatus elegans (Coquillett). The new records are associated largely with Malaise trap samples from Hemlock Draw (The Nature Conservancy), in the Baraboo Hills of Sauk County, and a Malaise trap at Kemp Natural Resources Station, in Oneida County, Wisconsin. Two specimens of K. clausus and a single specimen of K. militaris discovered within the research collection at the University of Wisconsin-Madison are also reported. The specimens …

First Records Of The Rare Nearctic Water Boatman Palmacorixa Janeae (Hemiptera: Corixidae) In The United States, Kurt L. Schmude, Gerald Shepard, Adam Frankiewicz

The Great Lakes Entomologist

We report the first record of the rare water boatman, Palmacorixa janeae Brooks (Hemiptera: Corixidae), from the United States. Two hundred and forty specimens were collected in Wisconsin from Chequamegon Bay in Lake Superior. Palmacorixa gillettei Abbott, a similar species known from the area, was also identified among the samples. Most specimens, all of which were adults, were collected at night using a neuston net towed along the surface for approximately 5 minutes. The adults were found in areas that were 34 meters to 4.2 kilometers from the shore that had depths ranging from 1.0 to 5.5 meters. All representatives …

Seasonal Emergence, Egg Gallery Characteristics, And Natural Enemies Of The Eastern Ash Bark Beetle, Hylesinus Aculeatus (Coleoptera: Curculionidae: Scolytinae), In Michigan, Robert A. Haack

The Great Lakes Entomologist

Hylesinus aculeatus Say (Coleoptera: Curculionidae: Scolytinae) commonly infests the trunks and limbs of recently dead, dying, or cut ash (Fraxinus spp.) trees in eastern North America. In the Great Lakes region, H. aculeatus is univoltine, overwinters as adults, breeds in late spring and early summer, and constructs transverse biramous egg galleries. I sampled trunk and branch sections from three small-diameter white ash (F. americana L.) trees that were cut in April 1986 in Ingham County, Michigan, and then naturally infested by H. aculeatus and associates. Bolts cut from these trees and placed in an outdoor rearing cage in …

Phenology Of Ground-Dwelling Beetle Assemblages (Coleoptera: Carabidae, Staphylinidae) From Three Fir Stands Of Southern Québec (Canada), With Comparison Among Selected Species Between 1985 And 2006-2010, Claire Levesque, Gilles-Yvon Levesque

The Great Lakes Entomologist

A total of 5,303 adult epigaeic beetles (Coleoptera) were collected using pitfall traps across three balsam fir (Abies balsamea (Linnaeus) Miller) stands in southern Québec (Canada). Sampling occurred during May–September 1985 in sites representing three distinct understory vegetation types. Three dominant families (Carabidae, Leiodidae and Staphylinidae) together represented at least 93% of catches at each site. Staphylinidae were less abundant than Carabidae at two sites, whereas Carabidae and Staphylinidae were collected in similar numbers at a third stand. Associated with increased abundance and heterogeneity of the understory vegetation, we observed 1) the decrease of specialist forest carabids, often active …

Caddisfly (Trichoptera) Assemblages From The Southern Laurentian Highlands, Québec (Canada), David C. Houghton

The Great Lakes Entomologist

The caddisflies (Trichoptera) represent an important taxon for the natural functioning of aquatic ecosystems and as biological monitoring organisms; however, basic information on their assemblages is still lacking in Canada. In this study, adult caddisflies from 30 lakes and streams in the southern Laurentian Highlands of Québec were sampled during 2023–2025. A total of 186 caddisfly species were determined, including 22 species not previously reported from Québec and eight not previously reported from anywhere in Canada. Two species of Cernotina also represented the first collection of that genus within the province. Using Indicator Species Analysis, six species indicated small rivers, …

Paper Wasp Species Polistes Fuscatus (Hymenoptera: Vespidae) Tracks Urban Lead (Pb) Levels More Than Polistes Dominula, Lindsey R. Kemmerling, Anna L. Lovat, Allison A. Hanka, Emilie C. Snell-Rood

The Great Lakes Entomologist

Lead (Pb) is a persistent, toxic pollutant with widespread but inequitably distributed impacts, especially for humans in urban areas. The impacts of lead pollution on other organisms is largely unknown, even as they commonly experience exposure to lead alongside humans. We tested hypotheses regarding the lead concentrations of paper wasps across a gradient of pollution relative to soil and human lead levels, and correlations with wasp body condition. We collected two species of paper wasp across an urban gradient of lead pollution: Polistes fuscatus (Fabricius) (Hymenoptera: Vespidae), native to our study location, and Polistes dominula (Christ), nonnative to our study …

Long-Term Monitoring And Response Of Papaipema Sciata Bird (Lepidoptera: Noctuidae) To Prescribed Fire In Michigan (Usa), Gregory J. Norwood, Logan M. Rowe, Brett A. Degregorio, David L. Cuthrell, Aaron D. Meredith, Steven M. Gray

The Great Lakes Entomologist

The Culver’s root borer moth (Papaipema sciata) (Lepidoptera: Noctuidae) is a rare Noctuid that requires Culver’s root (Veronicastrum virginicum) to complete its lifecycle within remnant native grasslands and open woodlands in the midwest and northeast United States. We report on 26 years of monitoring this species’ colonization of Culver’s root stems at Algonac State Park (ASP) in Michigan, where prairies have been maintained by prescribed fire since 1990. P. sciata is considered fire sensitive because eggs spend the dormant season in the combustible prairie litter and duff near host plants. The objectives were to determine the …

Could The European Thanasimus Formicarius Outcompete The North American Thanasimus Dubius (Coleoptera: Cleridae) If Introduced To North America?, Robert A. Haack, Robert K. Lawrence

The Great Lakes Entomologist

A federal quarantine was enacted in the United States (US) in the fall of 1992 in response to discovery of the Eurasian pine shoot beetle, Tomicus piniperda (L.) (Coleoptera: Scolytinae), in July 1992 in Ohio. The quarantine regulated movement of pine products (e.g., Christmas trees, nursery stock, and logs) at the county level from infested to uninfested US states. A classical biological program was considered for T. piniperda starting in 1995, focusing on the Eurasian clerid beetle Thanasimus formicarius (L.), an important predator of T. piniperda. Concerns were raised in 1996 that if T. formicarius were released in the …

Fecundity Of Thanasimus Dubius (Coleoptera: Cleridae) Rebounds After A Period Of Prey Scarcity, Robert A. Haack, Robert K. Lawrence

The Great Lakes Entomologist

We field-collected Thanasimus dubius (Fabricius) (Coleoptera: Cleridae) adults during spring, maintained them separately in the laboratory, and initially gave them four bark beetle adults [Ips grandicollis (Eichhoff) or Tomicus piniperda (L.) (Coleoptera: Curculionidae: Scolytinae)] daily as prey. Using a subset of the female clerids (N = 41), we assigned them to one of four feeding groups that varied in the number of prey provided daily. For the first four weeks of a 12–week study, the four diets were: four prey daily, two prey daily, one prey daily, and one prey every 2 days. After four weeks, all females were …

Distribution And Status Of Silphium Herb Gall Wasps (Cynipoidea: Aulacideini: Antistrophus) And Their Associated Endophytic Communities In Wisconsin, Richard A. Henderson, Louis F. Nastasi, Jay Watson, Scott Sauer

The Great Lakes Entomologist

At least six described species of the herb gall wasp genus Antistrophus Walsh (Hymenoptera: Cynipoidea: Aulacideini) are dependent on the plant genus Silphium L., a plant group emblematic of now-endangered Midwestern tallgrass prairies. The distribution and conservation status of Antistrophus gall wasps is mostly a mystery, and these insects have only recently been recorded from Wisconsin. We surveyed the state for Antistrophus gall wasps on four Silphium species, whole-leaf rosinweed (S. integrifolium Michx.), compass plant (S. laciniatum L.), cup plant (S. perfoliatum L.), and prairie dock (S. terebinthinaceum Jacq.) to determine their distribution and abundance in Wisconsin. We report new …

Cover Pages For Tgle Vol. 59 Nos. 1 & 2

The Great Lakes Entomologist

Cover Pages for TGLE Vol. 59 Nos. 1 & 2

Full Issue For Tgle Vol. 59 Nos. 1 & 2

The Great Lakes Entomologist

Full issue for TGLE Vol. 59 Nos. 1 & 2

Volume 9 (2026) Climate And Responsibility

International Journal on Responsibility

This issue focuses on the various ways responsibility affects environmental justice. Specifically, this volume urges us to think about how societal and individual (in)action influences ecological crises and what informs this behavior, with a specific focus on religious and Indigenous beliefs and values.

Evaluation Of Mdm2 Mrna Expression According To Clinicopathological Characteristics In Oral Squamous Cell Carcinoma (Oscc) Patients, Tirta Wardana

Chulalongkorn Medical Journal

Background: The murine double minute 2 (MDM2) gene encodes an E3 ubiquitin ligase that targets p53 for degradation, thereby influencing the pathogenesis of oral squamous cell carcinoma (OSCC).

Objective. The present study investigates MDM2 mRNA expression and its association with clinical and pathological characteristics in OSCC patients.

Methods: We conducted an observational-analytical study using a cross-sectional design. The study involved 39 OSCC patients. RNA extraction, cDNA synthesis, and quantitative PCR (qPCR) were performed. We quantified relative MDM2 mRNA expression using the Livak method (2-ΔΔCT) and GenEX MultiD software version 6.0. Statistical significance was assessed using independent t-tests.

Results: Although no …

Neuroinflammatory And Neuronal Damage Biomarkers In Depression: A Meta-Analysis Of Hmgb1, S100Β, And Nse Levels, Ikbal Andrian Malau, Suet-Kei Wu, Jane Pei-Chen Chang, Cheng-Ho Chang, Chun-Hung Chang, Ming-Jun Tsai, Yung-Chih Chiang, Kuan-Pin Su

BioMedicine

Background: Depression is associated with neuroinflammation and dysfunction of neurons and glial cells. Immune activation and damage-associated signals such as S100 calcium-binding protein B (S100β) and high mobility group box 1 (HMGB1) amplify inflammation, leading to neuronal injury. Neuron-specific enolase (NSE) reflects such injury. These molecules may serve as potential biomarkers of depression.

Aims: This study compared levels of S100β, HMGB1, and NSE in individuals with depression versus non-depressed controls.

Methods: PubMed, Embase, and Web of Science were searched up to April 5, 2025, using the terms “S100B AND Depression”, “neuron specific enolase AND Depression”, and “HMGB1 …

Design And Development Of Novel Peptidomimetic Compounds For Cancer Therapeutics: Focus On Hsp90–Cdc37 Interaction, Sarath Perumal, Ramanathan Karuppasamy

BioMedicine

Background: The HSP90 and CDC37 molecular chaperone complex governs the

stability and function of numerous client protein kinases, making it a crucial cancer target. Given their central role, disrupting this interaction induces proteotoxic stress and inhibits tumor progression. Therapeutic peptides are the mainstay of treatment for disruption of key interactions, yet they face limitations such as toxicity, resistance, and poor stability. Aim: This study aims to leverage peptidomimetics as novel disruptors of the HSP90–CDC37 interaction. Methods: Two peptides, a 9-mer and a 7-mer, were rationally designed by analyzing key regions facilitating HSP90–CDC37 complex formation. In silico mutational analysis identified …

Evaluation Of The Anti-Inflammatory Properties In Vitro, In Vivo And In Silico, Of The Snail Slime Helix Aspersa Müller, Marouane Aouji, Malak Zirari, Mariame Taibi, Meryem Lamdak, Amine Rkhaila, Rachid Bengueddour

BioMedicine

Background: The search for effective natural alternatives to synthetic non-steroidal antiinflammatory drugs (NSAIDs), which are often associated with undesirable side effects, is an important axis of current research. The slime of the snail Helix aspersa Müller, is a traditional remedy that deserves scientific investigation for its potential therapeutic properties.

Purpose: This study aimed to comprehensively evaluate the anti-inflammatory effects of Helix aspersa Müller slime using a combination of in vitro, in vivo, and in silico methodologies.

Methods: In vitro analyses included assays for inhibition of protein denaturation, antiprotease and antilipoxygenase activities, and membrane stabilization, with diclofenac and indomethacin as reference …

Traditional Chinese Medicine And Healthcare Utilization In Bipolar Disorder: A Population-Based Study With Propensity-Matched And Mirror-Image Analyses, Shu-Ping Chen, Su-Tso Yang, Kai-Chieh Hu, Hui-Chih Chang, Jane Pei-Chen Chang, Kuan-Pin Su

BioMedicine

Background: Bipolar disorder (BD) is a chronic relapsing illness associated with high rates of acute psychiatric hospitalizations (APH) and emergency services (ES) use, placing burdens on healthcare systems. Many patients seek complementary modalities, including traditional Chinese medicine (TCM), alongside standard pharmacotherapy. However, population-based evidence regarding TCM’s effect on acute healthcare utilization in BD is lacking.

Methods: Using data from Taiwan’s Longitudinal Health Insurance Database 2000 (LHID 2000), this population-based study employed propensity score matching (PSM) based on age, gender, the index year (defined as the calendar year of the index date for TCM users and their matched nonTCM counterparts), and …

Topical Peony And Licorice Decoction Attenuates Exercise-Induced Muscle Pain: A Randomized Double-Blind Self-Controlled Trial In Taiwan, Daniel Tzu-Li Chen, Chang-Wei Hsieh, Chia-Han Tsai, Tzung-Yan Lee, Pin-Chun Chen, Pu-Wei Hou, Kuan-Pin Su, Hen-Hong Chang

BioMedicine

Background

Delayed onset muscle soreness (DOMS) is a common phenomenon that occurs after exercise training, resulting in pain and reduced muscle performance. Previous basic and animal studies have reported that oral use of Peony and Licorice Decoction (PLD), a traditional Chinese formula with anti-inflammatory and muscle-relaxing properties, may be safe and effective for DOMS. However, there have been no clinical studies, particularly on the topical use of PLD, in this field to date.

Material and Methods

Our study is a double-blind, randomized, placebo-controlled trial. We recruited healthy male athletes to assess the effect of external PLD, whose bioactive compounds were …

A Causal Association Between Alkaline Phosphatase And Natural-Cause Mortality: A Mendelian Randomization Study In East Asians And Europeans., Hung-Lin Chen, Ping-Hsun Wu, Yi-Ting Lin, Amrita Chattopadhyay, Hsiu-Yin Chiang, Yu-Ting Lin, Ya-Chi Lin, Che-Chen Lin, Min-Yu Chiang, Hung-Chieh Yeh, I-Wen Ting, Yu-Cyuan Hong, David Ray Chang, Jenq-Wen Huang, Yu-Ting Lin, Wei-Chi Syu, Tzu-Pin Lu, Yi-Chun Tsai, Fuu-Jen Tsai, Chin-Chi Kuo

BioMedicine

Background: Although observational studies show a positive association between alkaline phosphatase (ALP) levels and mortality, a causal study is not yet available.

Objective: We conducted a retrospective cohort study and a systematic one-sample Mendelian randomization (MR) study to investigate the causality of ALP on natural-cause mortality.

Methods: The study used a hospital-based cohort of Asian patients recruited from the China Medical University Hospital (CMUH) and a community-based cohort of white European participants from the UK Biobank (UKB). Two retrospective cohorts included 43,994 patients from CMUH and 80,941 participants from UKB, all aged 50–55 years, with ALP measurements. For the MR …

The Association Between Rapid Growth In Children Under The Age Of Five And Adolescent Obesity, Ratu Ayu Dewi Sartika, Fadila Wirawan, Iche Andriyani Liberty, Nurul Husna Mohd Shukri, Siti Arifah Pujonarti, Edy Purwanto, Munaya Fauziah

Kesmas

Early-life nutrition is a critical predictor of long-term health, yet the association between rapid early-childhood growth and adolescent obesity, particularly in relation to the “double burden of malnutrition,” remains under-researched in Indonesia. This study aimed to analyze the association between rapid growth and adolescent obesity. Data were obtained from the 1997, 2000, and 2014 waves of the Indonesian Family Life Survey (IFLS). This study included 641 children (aged 0–23 months at baseline) with complete anthropometric measurements across all three waves. Rapid growth was defined as an increase in z-scores of >0.67 in weight-for-age (WAZ), height-for-age (HAZ), or weight-for-height (WHZ) between …

Environmental Perspective For System Dynamics Modeling Of Stunting Mitigation To Achieve The Sustainable Development Goals In West Sumatra, Indonesia, Elsa Yuniarti, Nabila Azzahra, Yulhendri Yulhendri, Heldi Heldi, Mery Delvina, Saskia Putri Azeli

Kesmas

This study developed a system dynamics model to simulate stunting reduction in West Sumatra Province, Indonesia, by integrating infant and toddler health, maternal health, and environmental determinants. Secondary data from 2020–2024 on low birth weight, immunization, malnutrition, exclusive breastfeeding, maternal chronic energy deficiency, iron and folic acid supplement distribution, sanitation, and safe drinking water access were compiled from West Sumatra Provincial Health Office and Statistics Indonesia, and validated through consultation with five stakeholder institutions. Causal Loop Diagrams mapped feedback relationships among determinants and were translated into Stock Flow Diagrams using Powersim Studio 10. The model was validated through structural verification, …

Crosstalk Between Upr And Mitochondria: The Triad Of Er-Mitochondria Contacts, Ca²⁺, And Ros, Ester Zito, György Hajnóczky

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Endoplasmic reticulum (ER) stress is triggered by several cellular perturbations causing protein misfolding, and activates the unfolded protein response (UPR), an initially adaptive signaling network that aims to restore ER and cellular homeostasis. Growing evidence indicates that UPR signaling extends beyond ER proteostasis, influencing mitochondrial function and bioenergetics through ER-mitochondria contact sites (ERMCs). The CHOP-ERO1A-IP3R axis has a primary role in recruiting mitochondria to adaptive UPR. However, its sustained activation renders UPR signaling maladaptive, leading to mitochondrial dysfunction through both outer mitochondrial membrane permeabilization (OMMP) and mitochondrial permeability transition pore (mPTP) opening, ultimately contributing to irreversible cell injury and disease …

The Correlation Between Medication Adherence, Blood Glucose Levels, And Quality Of Life In Patients With Type 2 Diabetes Mellitus At Ciamis Regional Hospital, Amyla Putri Nurul Nazmi, Nur Rahayuningsih, Lusi N

Pharmacology and Clinical Pharmacy Research

Type 2 diabetes mellitus is a chronic condition requiring continuous treatment, including patient adherence to prescribed medication. This study aimed to explore the relationship between medication adherence, blood glucose levels, and quality of life in patients with type 2 diabetes mellitus at Ciamis Regional Hospital, conducted from January to March 2025, the research employed a quantitative, prospective cross-sectional design involving 49 hospitalized patients. Data included blood glucose levels (RPG, FPG, 2hPG), medication adherence measured using the Medication Adherence Report Scale (MARS-5), and quality of life assessed via the Diabetes Quality of Life-Brief Clinical Inventory (DQOL-BCI). The chi-square test was used …

The Phytochemical Content And Antibacterial Activity Of Purified Extract Of Mangifera Indica L. Against Gram Positive Pathogen, Dewi Andini Kunti Mulangsri, Masduki Faqih, Sugar Arifin, Mutiara Trie Sieya Agustin

Pharmacology and Clinical Pharmacy Research

The purified extract of arum manis mango leaves contained flavonoid compounds by TLC methods and antibacterial activity against Gram-positive and negative pathogens. This research aimed to identify and determine the phytochemical content (mangiferin and flavonoids content) and antibacterial activity against other Gram-positive pathogens. Purification of ethanol extract of arum manis mango leaves by liquid-liquid fraction method. Determination of total flavonoid content and identification of mangiferin used respectively by aluminum chloride and Thin Layer Chromatography method. The disk diffusion method was used to assay antibacterial activity against S. epidermidis, and B. subtilis bacteria with the concentration of the sample such …

Innovating A Crustacean Embryo Toxicity (Cet) Assay For Screening Environmental Contaminants, Irina A. Polunina-Proulx

Graduate Doctoral Dissertations

Environmental pollutants can disrupt normal developmental processes, leading to neurobehavioral and developmental abnormalities. Toxicity tests are important for evaluating environmental contaminants; however, standard assays are often time- and cost-intensive and typically require large numbers of vertebrate animals. These limitations highlight the need to reduce reliance on vertebrate testing and to develop New Approach Methodologies that provide comparable results while improving efficiency and cost-effectiveness. This research utilizes a novel screening assay to evaluate developmental toxicity using Hyalella azteca. H. azteca is a freshwater amphipod widely used as a model organism for sediment toxicity in ecotoxicology, yet its embryos have been minimally …

Development Of Ultrafast Protein Digestion And Standards Free Quantitation Methods For Mass Spectrometric Analysis, Praneeth Ivan Joel Fnu

Dissertations

A wide variety of biologically important molecules, such as enzymes, antibodies, hormones, transporters and receptors are proteins by composition and they play key roles in biological functions such as cellular regulation, communication, metabolism and physiological function. Protein dysfunctions and abnormalities are associated with numerous diseases, making proteins critical targets for understanding disease mechanisms and developing therapeutic interventions. Protein-based therapeutics such as monoclonal antibodies, hormones and vaccines gained popularity due to their high specificity, efficacy, and ability to treat complex diseases that are often difficult to address with small-molecule drugs.

Given the important role of proteins in a variety of biological …

Geographic And Environmnetal Influences On Color Pattern Similarity Between Coral Snakes (Genus: Micrurus) And Their Lookalikes, Anthony Sena

Dissertations

Venomous coral snakes and their lookalikes are often regarded as a classic example of Batesian mimicry, whereby a harmless species imitates a harmful species. The existing literature regarding coral snake resemblance presents a divisive stance on whether Batesian mimicry is the primary driver of shared color patterns or if alternative factors are responsible. While recent literature largely favors the Batesian hypothesis, empirical support remains inconsistent, and the specific geographic and interpretation of the conditions required for mimicry lacks consensus within the scientific community.

To evaluate the mechanisms maintaining these phenotypes, a quantitative, multivariate framework was utilized to analyze 400 museum …