Digital Commons Network^™

Medical Image Segmentation Assisted With Clinical Inputs Via Language Encoder In A Deep Learning Framework, Hengrui Zhao, Biling Wang, Deepkumar Mistry, Jing Wang, Michael Dohopolski, Daniel Yang, Weiguo Lu, Steve Jiang, Dan Nguyen

Faculty, Staff and Student Publications

Introduction: Auto-segmentation of tumor volumes and organs at risk (OARs) is a critical step in cancer radiotherapy treatment planning, where rapid, precise adjustments to treatment plans are required to match the patient anatomy. Although auto-segmentation has been clinically accepted for most OARs, auto-segmentation of tumor volumes, particularly clinical target volumes (CTVs), remains a challenge. This difficulty arises because images alone are often insufficient to capture the necessary information for accurate delineation of microscopic tumor invasion invisible on the image itself.

Methods: We propose a deep learning-based medical image segmentation framework designed to mimic the clinical process of delineating CTVs and …

Difference-Makers For Collecting Sexual Orientation And Gender Identity Data In Oncology Settings, Mandi L Pratt-Chapman, Edward J Miech, Megan A Mullins, Shine Chang, Gwendolyn P Quinn, Shail Maingi, Matthew B Schabath, Charles Kamen

Faculty, Staff and Student Publications

Purpose: The purpose of this analysis was to identify key difference-making conditions that distinguish oncology institutions that collect sexual orientation and gender identity (SOGI) data across a sample of American Society of Clinical Oncology (ASCO) members.

Methods: From October to November 2020, an anonymous 54-item web-based survey was distributed to ASCO members. Coincidence analysis was used to identify difference-making conditions for the collection of SOGI data.

Results: ASCO members' responses to just three items consistently distinguished practices that reported collecting both SO and GI data (n = 25) from those who did not (n = 20): (1)."Do you ask your …

An Automated Treatment Planning Portfolio For Whole Breast Radiotherapy, Hana Baroudi, Leonard Che Fru, Deborah Schofield, Dominique L Roniger, Callistus Nguyen, Donald Hancock, Christine Chung, Beth M Beadle, Kent A Gifford, Tucker Netherton, Joshua S Niedzielski, Adam Melancon, Manickam Muruganandham, Meena Khan, Simona F Shaitelman, Sanjay Shete, Patricia Murina, Daniel Venencia, Sheeba Thengumpallil, Conny Vrieling, Joy Zhang, Melissa P Mitchell, Laurence E Court

Faculty, Staff and Student Publications

Background: Automation in radiotherapy presents a promising solution to the increasing cancer burden and workforce shortages. However, existing automated methods for breast radiotherapy lack a comprehensive, end-to-end solution that meets varying standards of care.

Purpose: This study aims to develop a complete portfolio of automated radiotherapy treatment planning for intact breasts, tailored to individual patient factors, clinical approaches, and available resources.

Methods: We developed five automated conventional treatment approaches and utilized an established RapidPlan model for volumetric arc therapy. These approaches include conventional tangents for whole breast treatment, two variants for supraclavicular nodes (SCLV) treatment with/without axillary nodes, and two …

In Pursuit Of Ki-Rads: Toward A Single, Evidence-Based Imaging Classification Of Renal Masses, Stuart G Silverman, Ivan Pedrosa, Nicola Schieda, Vitaly Margulis, Payal Kapur, Matthew S Davenport

Faculty, Staff and Student Publications

Despite the successful application of Imaging Reporting and Data Systems to improve the radiologic description and management of disease in many organs, one does not yet exist for the kidney. Instead, the radiologic approach to the kidney has focused on the Bosniak classification system, which is based on imaging characteristics for cystic renal masses, and detecting macroscopic fat within solid renal masses. Radiologically, cystic and solid renal masses are categorized and evaluated separately because of historical precedent, differences in appearance at imaging, and differences in biologic behavior. However, the World Health Organization classification of renal neoplasms does not support such …

Proteasome Augmentation Mitigates Age-Related Cognitive Decline In Mice, Danitra Parker, Kanisa Davidson, Pawel A Osmulski, Maria Gaczynska, Andrew M Pickering

Faculty, Staff and Student Publications

The aging brain experiences a significant decline in proteasome function. The proteasome is critical for many key neuronal functions including neuronal plasticity, and memory formation/retention. Treatment with proteasome inhibitors impairs these processes. Our study reveals a marked reduction in 20S and 26S proteasome activities in aged mice brains, including in the hippocampus, this is driven by reduced functionality of aged proteasome. The decline in proteasome activity is matched by a decline in 20S proteasome assembly. In contrast, 26S proteasome assembly was found to increase with age, though 26S proteasome activity was still found to decline. Our data suggests that age-related …

Safety And Efficacy Of Dtx401, An Aav8-Mediated Liver-Directed Gene Therapy, In Adults With Glycogen Storage Disease Type I A (Gsdia), David A Weinstein, Terry G Derks, David F Rodriguez-Buritica, Ayesha Ahmad, María-Luz Couce, John J Mitchell, Rebecca Riba-Wolman, Malaya Mount, Julieta Bonvin Sallago, Katalin M Ross, Melanie M Van Der Klauw, Foekje De Boer, Caroline Van Der Schaaf, Heather Saavedra, Miguel Martínez-Olmos, Elvis Atanga, Asad Hosseini, Deepali Mitragotri, Eric Crombez

Faculty, Staff and Student Publications

Glycogen storage disease type Ia (GSDIa) is a rare, life‐threatening, inherited carbohydrate metabolism disorder caused by glucose‐6‐phosphatase (G6Pase) deficiency, which is essential for glycogenolysis and gluconeogenesis. GSDIa management includes a strict medically prescribed diet that typically includes daily uncooked cornstarch doses, including overnight, to maintain euglycemia. DTX401 is an investigational adeno‐associated virus serotype 8 vector expressing the human G6PC1 gene that encodes G6Pase. This open‐label, phase 1/2, dose‐escalation, 52‐week gene therapy trial evaluated the safety and efficacy of a single DTX401 infusion in 12 adults with GSDIa (ClinicalTrials.gov Identifier: NCT03517085). Three participants in Cohort 1 received DTX401 2.0 × …

Overexpression And Biophysical And Functional Characterization Of A Recombinant Fgf21, Phuc Phan, Jason Hoang, Thallapuranam Krishnaswamy Suresh Kumar

Chemistry & Biochemistry Faculty Publications and Presentations

Fibroblast growth factor 21 (FGF21) is an endocrine FGF that plays a vital role in regulating essential metabolic pathways. FGF21 increases glucose uptake by cells, promotes fatty acid oxidation, reduces blood glucose levels, and alleviates metabolic diseases. However, detailed studies on its stability and biophysical characteristics have not been reported. Herein, we present the overexpression, biophysical characterization, and metabolic activity of a soluble recombinant FGF21 (rFGF21). The far-UV circular dichroism spectra of rFGF21 show a negative trough at 215 nm, indicating that the protein’s backbone predominantly adopts a β sheet conformation. rFGF21 shows intrinsic tyrosine fluorescence at 305 nm. Thermal …

A High-Lipid Diet Leads To Greater Pathology And Lower Tolerance During Infection, Weston Gerald Perrine, Erin Sauer, Ashley C. Love, Ashley Morris, Johnathan Novotny, Sarah Durant

Biological Sciences Faculty Publications and Presentations

Altered food landscapes contribute importantly to wildlife disease dynamics and may play a critical role in host heterogeneity in disease outcomes through changes in host diet composition. We explored the effects of dietary macronutrient composition on disease pathology and feeding behavior of canaries (Serinus canaria domestica) infected with Mycoplasma gallisepticum (MG). In the first experiment, we provided canaries with isocaloric diets composed of identical ingredients that varied in macronutrient content (high protein or high lipid) then MG- or sham-inoculated birds. In the second experiment, we offered both diets to canaries before and after MG or sham inoculation. In experiment one, …

Predation Of The Scorpion Hottentotta Saulcyi (Scorpiones: Buthidae) By The Long-Eared Hedgehog (Hemiechinus Auritus) (Mammalia: Eulipotyphla: Erinaceidae) In Şırnak Province, Türkiye, Rıdvan Kurt, Ersen A. Yağmur, Tarkan Yorulmaz

Euscorpius

In this study, we report the predation of Hottentotta saulcyi (Simon, 1880) by the insectivorous mammal Hemiechinus auritus (Gmelin, 1770) in Şırnak Province, southeastern Türkiye. During a nighttime field trip, we observed a long-eared hedgehog biting a H. saulcyi individual on its prosoma. This observation confirms that long-eared hedgehogs feed on and prey upon scorpions.

Edge Feathering Across Forest-Meadow Ecotones Increases Light Heterogeneity And Understory Plant Diversity, Aruni Kadawatha, Jean H. Burns

Faculty Scholarship

Ecotones, the transitional zones between distinct habitats, are vital for ecosystem functioning and habitat diversity. Traditional management practices frequently create abrupt boundaries, leading to stressful conditions for organisms. To address this challenge, an underutilized land management technique called “edge feathering”, which involves gradual thinning of the canopy along the forest edge, has been introduced. This study, con- ducted at Holden Arboretum in Kirtland, Ohio, investigated the effects of edge feathering on light availability and understory plant diversity in edge feathered and control treatments. We calculated the coefficient of variation in light availability as light heterogeneity and plant diversity indices at …

Too Much Of A Good Thing: Lessons From Compromised Rootworm Bt Maize In The Us Corn Belt, Ziwei Ye, Christina Difonzo, David A. Hennessy, Jinhua Zhao, Felicia Wu, Shawn P. Conley, Aaron J. Gassmann, Erin W. Hodgson, Bryan Jensen, Janet J. Knodel, Bradley Mcmanus, Lance J. Meinke, Andrew Michel, Bruce Potter, Nicholas J. Seiter, Jocelyn L. Smith, Joseph L. Spencer, Kelley J. Tilmon, Robert J. Wright, Christian H. Krupke

Department of Entomology: Faculty Publications

Widespread use of genetically engineered maize targeting the corn rootworm complex (Diabrotica species) has raised concerns about insect resistance. Twelve years of university field trial and farm survey data from ten United States Corn Belt states indicate that maize hybrids expressing toxins derived from the bacterium Bacillus thuringiensis (Bt maize) exhibited declining protection from rootworm feeding with increased planting while pest pressures simultaneously decreased. The analysis revealed a tendency to overplant Bt maize, leading to substantial economic losses; this was particularly striking in eastern Corn Belt states. Our findings highlight the need to go beyond the “tragedy of the …

Exploring Managed Retreat Pathways To Community-Led Resilience 1-31-2025, Roger Williams University School Of Law, Marine Affairs Institute

School of Law Conferences, Lectures & Events

No abstract provided.

Muscle-Specific Errγ Activation Mitigates Muscle Atrophy After Acl Injury, Aiping Lu, Katie J Sikes, Ping Guo, Matthieu Huard, Shelbi Green, Kelly Santangelo, Jacob Singer, Ashley Groesbeck, Scott Tashman, Vihang A Narkar, Johnny Huard

Faculty, Staff and Student Publications

Anterior cruciate ligament (ACL) injury adversely affects skeletal muscle, leading to muscle atrophy and weakness, significantly impacting clinical outcomes. This study aimed to determine if estrogen-related receptor gamma (ERRγ) overexpression in skeletal muscle could mitigate muscle atrophy after ACL injury. An animal model with selective overexpression of ERRγ in skeletal muscle (ERR-gamma transgenic mice, TG) and WT control mice were used for this study. All the mice received a mechanical ACL rupture and were euthanized at 4- and 8-week post-injury. Muscle histology, atrophy, and function were evaluated and compared between the TG and WT mice. Muscle-specific ERRγ activation in TG …

Current Challenges And Preliminary Morphological Reassessment Of The Genus Chaerilus Simon, 1877 In China (Scorpiones: Chaerilidae), Victoria Tang

Euscorpius

The genus Chaerilus Simon, 1877 in China is preliminarily revised on a morphological basis, derived from the available literature and newly examined specimens. The robustness of several commonly applied species-level diagnostic criteria are evaluated. Ten species are provisionally recognized for China, including one new morphospecies, Chaerilus herta sp. n., described from 9 females, 40 males, and 2 juvenile females collected in Mêdog County. The current study only reveals and resolves several most elementary issues in the taxonomy of Chinese Chaerilus. Further molecular investigations are warranted until topotypes of certain species become available.

Plasma Levels Of Mir-21b And Mir-146a Can Discriminate Rheumatoid Arthritis Diagnosis And Severity., Rizk S. Sarhan, Amr M El-Hammady, Yasmin M Marei, Sania K Elwia, Doaa M Ismail, Emtethal As Ahmed

BioMedicine

Objectives: This study tried to examine the ability of the estimated plasma gene-expression levels (PGEL) of microRNA (miR)-146a and miR-21b to distinguish patients with early rheumatoid arthritis (RA) out of arthritis patients who did not fulfill the diagnostic spectrum of either RA or osteoarthritis (OA); the diagnostic Gray-Zone (GZ).

Patients & Methods: Enrolled patients underwent full diagnostic workup and were categorized as highseropositive and fulfilled the diagnostic spectrum for RA (RA-group), seronegative and fulfilling the diagnostic spectrum of OA (OA-group) and low-seropositive or seronegative patients who did not fulfill diagnostic criteria of RA or OA (GZ-group). Blood samples were obtained …

In-Silico Study Of Rosmarinic Acid Roles In Inhibiting Breast Cancer Progression, Ngakan Putu Krishna Mahayana, Ngurah Bagus Agung Surya Nanda Jayesvara Dwi Sutanegara, Made Dwinanda Prabawa Mahardana, Desak Made Wihandani

BioMedicine

Background: Breast cancer is the highest cancer incidence in the world. Chemotherapy is currently one of the main breast cancer treatments besides surgery. It is capable of evolving to become resistant to chemotherapy agents. Chemotherapy also has significant side effects. Rosmarinic acid could become an anti-cancer agent candidate for the treatment of breast cancer, but its molecular mechanism is still unclear.

Aim: This study aimed to clarify the molecular mechanism of rosmarinic acid anti-breast cancer properties via an in-silico study.

Methods: Web-based screening tools such as SwissTargetPrediction, Similarity Ensemble Approach (SEA), and TargetNet were used as initial screening. From web-based …

Unveiling Role Of Oncogenic Signalling Pathways In Complicating Breast Cancer, Acharya Balkrishna, Sagar Kumar, Rohan Malik, Kuldeep Singh Mehra, Hariom Chaturvedi, Okeshwar Okeshwar, Rashmi Mittal

BioMedicine

Heterogeneous nature of breast cancer has significantly affected the overall survival, disease free survival and progression free survival amongst the diseased individuals. Metastasis of cancerous cells to distant sites including bone, lungs, liver, lymph node and others have further exhilarated the adverse effects. However, ER, PR and HER-2 are responsible for normal physiological development of women but in altered conditions they may act as initiator or progressor and so far 5 subtypes of disease have been identified. Alteration of pro-survival, pro-proliferative and anti-apoptotic pathways including JAK/STAT, MAPK,

PI3K/AkT/mTOR, NF-κB, BCL2 and several others have induced oncogenic events including epithelial-mesenchymal transition, …

Evaluating The Health Performance Of Mass Housing Projects In Egypt Lighting Design Of Dar Masr Project, New Damietta, Hala Mohamed Raslan, Huda El-Baz M.

Mansoura Engineering Journal

The Egyptian government has recently established many governmental mass housing projects to meet the housing needs nationwide. These projects are characterized by their unified repetitive design that rarely consider geographic, climatic and social variations from one site to another. The study objectives are to examine the health performance of mass housing projects; “Dar Misr” as an example. Dar Misr consists of 150,000 units distributed over 15 different cities, and is fully finished with unified electrical installations and preinstalled luminaires. The study examines the health performance of the project’s lighting design, both natural and electrical light, using the “WELLV2 rating system …

Simplification Of Woody Plant Trait Networks Among Communities Along A Climatic Aridity Gradient, Camila D. Medeiros, Santiago Trueba, Christian Henry, Leila R. Fletcher, James A. Lutz, Rodrigo Méndez‐Alonzo, Nathan J. B. Kraft, Lawren Sack

Wildland Resources Faculty Publications

1. Plant ecological strategies are shaped by numerous functional traits and their trade-offs. Trait network analysis enables testing hypotheses for the shifting of trait correlation architecture across communities differing in climate and productivity.

2. We built plant trait networks (PTNs) for 118 species within six communities across an aridity gradient, from forest to semi-desert across the California Floristic Province, based on 34 leaf and wood functional traits, representing hydraulic and photosynthetic function, structure, economics and size. We developed hypotheses for the association of PTN parameters with climate and ecosystem properties, based on theory for the adaptation of species to low …

Leveraging Arginine Catabolism To Treat Metabolic Complications, Yiming Zhang

Arts & Sciences Graduate Student Theses and Dissertations

Fasting and caloric restriction are effective to treat patients with pre-diabetes or metabolic dysfunction-associated steatotic liver disease (MASLD), previously known as non-alcoholic fatty liver disease (NAFLD), but intensive lifestyle changes are difficult for many to implement and sustain. Therefore, by identifying and studying fasting-mediated signals, we hope to elicit and convey the therapeutic effects of fasting against MASLD without actual physiological fasting. We discovered a key pathway in the liver through unbiased transcriptomic screening in fasted mice, a novel glucose fasting-activated effector: the amino acid hydrolase, arginase 2 (ARG2). Our previously published data demonstrates that forced hepatocyte-specific Arg2 overexpression is …

Fecal Microbiota Of Healthy Arabian Camels (Camelus Dromedarius): A Comprehensive Study Investigating Various Factors (Food, Camel Type, And Drinking Water) And Their Influence On Fecal Microbiome Diversity In Arabian Camels, Ruqaiah Ali Qarwan

Thesis/ Dissertation Defenses

In UAE, dromedary camels (Camelus dromedarius) are considered as vital sources of meat and milk, and they also symbolize the cultural heritage of the region. Understanding healthy dromedary camel’s core microbiome and microbiome diversity is essential for their conservation and sustainable management. To explore the fecal microbiome diversity and core fecal microbiome of healthy dromedary camels, in this study, we analyzed 150 fecal samples from camels collected across 10 different farms in the Dubai region. Each farm maintains healthy camels and provides specific diets and water types, with some farms also focusing on camels for racing purposes. In this study, …

Changing Fire Regimes In The Great Basin Usa, Eva K. Strand, Kori Blankenship, Corey Gucker, Mark Brunson, Eugénie Montblanc

Aspen Bibliography

Wildfire is a natural disturbance in landscapes of the Western United States, but the effects and extents of fire are changing. Differences between historical and contemporary fire regimes can help identify reasons for observed changes in landscape composition. People living and working in the Great Basin, USA, are observing altered fire conditions, but spatial information about the degree and direction of change and departure from historical fire regimes is lacking. This study estimates how fire regimes have changed in the major Great Basin vegetation types over the past 60 years with comparisons to historical (pre-1900) fire regimes. We explore potential …

Flow Dynamics Of Agricultural Waste Nanofibers: Shear, Temperature, And Oscillatory Insights, Bilge N. Altay, Burak Aksoy, James Atkinson, Christopher Lewis, Carlos Diaz-Acosta, Raymond Francis

Articles

The rheology and fiber size of corn stover (CS) and cleaned cotton gin trash (CGT) cellulose nanofibers (CNFs) were studied including behaviors at both moderate and extremely high shear rates, to simulate industrial processes ranging from mixing and pumping to high-speed coating, printing, and extrusion. Particle size analyzer showed that 99% of CS fibers measured around 226 nm, while 85% of CGT fibers were approximately 143 nm. Both CS and CGT CNFs formed gel-like suspensions, and shear flow tests revealed that all samples exhibited shear-thinning behavior, allowing easy flow under shear forces. Gels with higher solid content (1%) demonstrated extended …

Variation In Thermal Tolerance Plasticity And The Costs Of Heat Exposure In The Estuarine Sea Hare, Phyllaplysia Taylori, Richelle L. Tanner, Rauri C. K. Bowie, Cynthia Y. Wang-Claypool, Jonathan H. Stillman

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

Climate change is increasing average temperatures and the frequency and intensity of thermal extremes in coastal marine environments. Organisms in coastal marine habitats are accustomed to environmental fluctuations and possess physiological plasticity that may be advantageous in response to increased occurrence of extremes. To examine whether such plasticity is locally adapted to environmental conditions, we investigated the relationship between genetic diversity and thermal tolerance plasticity in 11 populations of the direct-developing intertidal sea hare, Phyllaplysia taylori, on the western coast of the United States. Using whole-organism metrics of muscle function and metabolic rate and a ddRADseq genomic approach, we …

Associations Of Parental Perceived Health With Child Movement Behaviors Within Two-Parent Households, You Fu, Hayley Almes, Nora Constantino, Doria Schmidt, Ryan D. Burns

International Journal of Physical Activity and Health

This study aimed to examine how perceived parental mental and physical health status was associated with child physical activity, screen time, and sleep. Participants were 6- to 17-year-old minors (N = 20,156; 47.9% female) from the 2022 US National Survey of Children’s Health. Dependent variables were children’s physical activity frequency, screen time, and sleep. Independent variables were parents’ physical and mental health status. Using the Actor-Partner Interdependence Model, two adjusted path models were constructed. One for parent mental health associating with parental physical health, another for parent physical health associating with parental mental health–both further associating with child movement behaviors. …

Let’S Be Cool About It: Anticipating Proper, Whole-Human Cryopreservation And The Necessary Oversight For Adequate Consumer Protection, Peter Lyon

Minnesota Journal of Law, Science & Technology

No abstract provided.

Joint Angular Kinematics And Gross Motor Function In Typically Developing Healthy Children, Monday Omoniyi Moses, Ngozi Florence Onuegbu, Prince De-Gualle Deku, Mary Abena Nyarko, Lydia Boampong Owusu, Abigael Omowumi Emikpe, Emmanuel Babatunde John, Rahul Soangra, Abiboye Cheduko Yifieyeh, Nicholas Akinwale Titiloye

Physical Therapy Faculty Articles and Research

Objective: The aim of this study was to establish the interactions between joint angular kinematics and gross motor function in typically developing healthy Ghanaian children. Methods: A descriptive cross-sectional study design was employed. A total of 150 (69 (46.0%), 3.25 ± 0.08-year-old boys and 81 (54.0%), 3.25 ± 0.06-year-old girls) 2–4-year-old children were recruited. Joint angular kinematic variables [left hip flexion (LHF), left hip extension (LHE), right hip flexion (RHF), left knee flexion (LKF), right hip extension (RHE), left knee extension (LKE), right knee flexion (RKF), left ankle dorsi-flexion (LADF), right knee extension (RKE), right ankle plantar flexion (RAPF), left …

Pskh1 Kinase Activity Is Differentially Modulated Via Allosteric Binding Of Ca2+ Sensor Proteins, Christopher R Horne, Toby A Dite, Samuel N Young, Lucy J Mather, Laura F Dagley, Jared L Johnson, Tomer M Yaron-Barir, Emily M Huntsman, Leonard A Daly, Dominic P Byrne, Antonia L Cadell, Boaz H Ng, Jumana Yousef, Dylan H Multari, Lianju Shen, Luke M Mcaloon, Gerard Manning, Mark A Febbraio, Anthony R Means, Lewis C Cantley, Maria C Tanzer, David R Croucher, Claire E Eyers, Patrick A Eyers, John W Scott, James M Murphy

Children’s Nutrition Research Center Staff Publications

Protein Serine Kinase H1 (PSKH1) was recently identified as a crucial factor in kidney development and is overexpressed in prostate, lung, and kidney cancers. However, little is known about PSKH1 regulatory mechanisms, leading to its classification as a “dark” kinase. Here, we used biochemistry and mass spectrometry to define PSKH1’s consensus substrate motif, protein interactors, and how interactors, including Ca2+ sensor proteins, promote or suppress activity. Intriguingly, despite the absence of a canonical Calmodulin binding motif, Ca2+-Calmodulin activated PSKH1 while, in contrast, the ER-resident Ca2+ sensor of the Cab45, Reticulocalbin, Erc55, Calumenin (CREC) family, Reticulocalbin-3, suppressed PSKH1 catalytic activity. In …

Monitoring And Modeling Legacy Tree Response To Restoration Treatments In The Klamath Mountains, Oregon, Usa, Isaac Joseph Ball

Dissertations and Theses

Climate change and its disruption of historical drought and wildfire patterns pose a substantial threat to forest health in the western United States. This threat is compounded by past management practices like fire suppression. The largest, oldest, and most ecologically valuable trees are particularly vulnerable, making their conservation a key objective of climate-adaptive forest management. Restoration treatments such as mechanical thinning have been shown to enhance tree growth and drought resilience in dry conifer forests, but long-term monitoring is necessary to understand their sustained effects. This study used dendroecological tree-ring analysis to investigate the effects of thinning on the growth, …

Immunological Biomarkers Of Response And Resistance To Treatment With Cabozantinib And Nivolumab In Recurrent Endometrial Cancer, Vladimir Roudko, Diane Marie Del Valle, Emir Radkevich, Geoffrey Kelly, Xie Hui, Manishkumar Patel, Edgar Gonzalez-Kozlova, Kevin Tuballes, Howard Streicher, Swati Atale, Lisa Wang, Benito Czinczin, Seunghee Kim-Schulze, Ignacio I Wistuba, Cara L Haymaker, Gheath Al-Atrash, Ganiraju Manyam, Jianjun Zhang, Ryan Thompson, Mayte Suarez-Farinas, Stephanie Lheureux, Sacha Gnjatic

Faculty, Staff and Student Publications

Background: Antiangiogenics combined with immune checkpoint blockade have become standard of care for recurrent endometrial cancer after standard platinum-based chemotherapy. To dissect mechanisms and define biomarkers associated with clinical outcomes to these combinations, we applied multidimensional immune monitoring to peripheral blood specimens collected from a randomized phase 2 trial of nivolumab with or without cabozantinib in 75 evaluable patients with recurrent endometrial cancer (NCI ETCTN 10104, NCT03367741). This trial demonstrated superiority of the combination to nivolumab alone.

Methods and results: Using Olink proteomics, mass cytometry, tumor antigen-specific ELISA, and whole exome tumor sequencing, we identified longitudinal immune signatures specific …