Digital Commons Network^™

Biopcm-Integrated Smart Façade For Hospitals: Thermal Performance Across Floor Levels In A Hot-Arid Climate, Aia A. Qindil, Esraa Elazab, Mohamed M. Shawky Abou Liela

Mansoura Engineering Journal

Hospitals are among the most energy-intensive building types because they operate around the clock and must maintain strict indoor environmental conditions, especially in hot-arid climates. Improving their performance calls for façade solutions that can store thermal energy effectively and help cut carbon emissions. This study evaluates the use of macro-encapsulated BioPCM® within the south façade of a high-rise hospital in Mansoura, Egypt, using dynamic simulations in DesignBuilder (EnergyPlus). The analysis focuses on two vertical levels, the third floor as a typical ward and the seventh floor as a rooftop ward, to investigate how elevation influences PCM performance, an aspect rarely …

Credit Card Fraud Detection Using Metaheuristic Techniques, Narges Sabry Anwer Mohammed, Mohammed Sabry Saraya, Amr M. Thabet, Labib M. Labib

Mansoura Engineering Journal

Credit Card Fraud Detection (CCFD) has become a critical challenge to financial security due to increasingly sophisticated fraudulent activities. This study investigates the effectiveness of Meta-Heuristic (MHT) optimization techniques in improving fraud detection (FD) through feature selection (FS) and model optimization. To address class imbalance, Random Under-Sampling (RUS) was applied. The selected feature subsets were evaluated using three machine learning (ML) classifiers—Decision Tree (DT), KNearest Neighbours (KNN), and XGBoost (Xgb-Tree)—across four benchmark datasets: European, Statlog (Australian Credit Approval), PaySim, and Credit Card Transactions Fraud Detection (CCTFD). Eleven binary MHT algorithms were implemented and compared. The comparative analysis shows that the …

Table Of Contents

Journal of the South Carolina Academy of Science

No abstract provided.

The Effect Of Macadamia Nut Oil Solution On The Growth Of Saccharomyces Cerevisiae, Yashas Peddireddy

Journal of the South Carolina Academy of Science

No abstract provided.

Spatiotemporal Analysis Of Genetic Perturbations Reveals A Genetic Cascade Driving Tribolium Gap Gene Initialization, Mahla Ahmadi, Heike Rudolf, Christine Mau, Jimena Garcia-Guillen, Ezzat El-Sherif

School of Integrative Biological & Chemical Sciences Faculty Publications

The ‘French flag’ model has long served as the prevailing framework for explaining how morphogen gradients generate spatial domains during embryonic development. However, recent evidence indicates that many tissues establish patterns by translating the sequential activation of genes into spatial domains. While the sequential nature of this process is becoming clear, the mechanisms that mediate these temporal dynamics and translate them into stable spatial boundaries remain debated. Using the gap gene network in the flour beetle Tribolium castaneum [which mediates the regionalization of the anterior-posterior (AP) axis into different axial fates through the regulation of downstream Hox genes] as a …

Dietary Flavonoid Intake And Psychological Well-Being – A Bidirectional Relationship, Alysha S. Thompson, Nicola P. Bondonno, Yan Lydia Liu, Farah Qureshi, Laura D. Kubzansky, Claudia Trudel-Fitzgerald, Julia K. Boehm, Eric B. Rimm, Aedín Cassidy

Psychology Faculty Articles and Research

Background and aim

Methods

Evaluation Of Mcf-7 Breast Cancer Cell Cytotoxic And Antioxidant Activities Of Peptide Fractions From Symbiotic Bacteria Of Jellyfish Catostylus Sp., Eka Sry Wahyuni, Ahyar Ahmad, Muhammad Nasrum Massi, Sofa Fajriah, Randi Rimpung, Muh. Akbar Ardiputra, Harningsih Karim, Irda Handayani

Karbala International Journal of Modern Science

Marine-derived symbiotic microorganisms are recognized as a promising source of bioactive compounds with potential therapeutic applications, yet research on jellyfish-associated bacteria remains limited. This study examines the bioactivity of peptide fractions derived from symbiotic bacteria isolated from the jellyfish Catostylus sp., collected from the coastal waters of South Sulawesi, Indonesia, with a focus on their anticancer and antioxidant properties. Following sample collection, the symbiont bacteria were isolated, enzymatically hydrolyzed, and purified before their biological activity was evaluated. Preliminary cytotoxicity screening using the brine shrimp lethality assay revealed that the extracellular peptide fraction (5–10 kDa) and intracellular peptide fraction (3–5 kDa) …

Foxo1 Inhibition And Fadd Knockdown Have Opposing Effects On Anticancer Drug-Induced Cytotoxicity And P21 Expression In Osteosarcoma Cells, Danielle Walker, Antanay Hall, Alexis Bonwell, Nancy Gordon, Danielle Robinson, Mario G Hollomon

Faculty, Staff and Student Publications

Forkhead box class O1 (FOXO1) and fas-associated death domain (FADD) regulate cell death pathways and homeostatic processes such as cell cycle progression and apoptosis. FADD phosphorylation promotes nuclear localization of FOXO1, and FOXO1 regulates FADD expression. Therefore, it is plausible that FOXO1 and FADD have synergistic or antagonistic effects on cell cycle regulation and the response to anticancer drug treatment in cancer cells. In the present study, we report that AS1842856-mediated inhibition of FOXO1 reverses anticancer drug-induced cytotoxicity, while FADD knockdown increases anticancer drug-induced cytotoxicity in osteosarcoma (OS). Reversed anticancer drug-induced cytotoxicity was accompanied by G2/M cell cycle arrest and …

Global Deep-Sea Hydrothermal Deposit Metagenomes And Metagenome-Assembled Genomes Over Time And Space, Emily St John, Anna-Louise Reysenbach

Center for Life in Extreme Environments Publications

Actively venting high temperature deep-sea hydrothermal vent deposits along tectonic spreading centers and in backarc basins harbor a rich diversity of thermophilic Bacteria and Archaea, many of which have no representatives in cultivation nor any genomic representation in databases. Here, in order to produce a global-scale time series metagenomic resource for studying the microbial functional and genomic diversity in these high temperature ecosystems, we obtained 70 metagenomes from collections across spatial and temporal gradients from 21 different vent fields spanning 16 years (1993-2009). The dataset (Deep-Sea Hydrothermal Vent dataset (DSV70)) includes 3.56 Tbp of raw DNA sequence reads, that have …

The Ethical Limits Of Physician Autonomy In Reproductive Medicine, Isabel Martens

Honors Theses

In vitro fertilization is a relatively new medical practice that helps people who face infertility be able to reproduce. Reproductive medicine providers face ethical dilemmas often in their field, only some of which have standards of care. There are questions in the medical landscape pertaining to physician autonomy versus patient autonomy, which heavily apply to reproductive medicine providers. Patient autonomy is highly valued in medical ethics; however, physician autonomy should also be considered. When a physician decides who can and cannot reproduce, ethical considerations must be followed to maintain the practice of reproductive autonomy. Limited policies exist that manage reproductive …

Elevated Trna Halves In Olfactory Epithelial Cells Of Patients With Schizophrenia, Justin T. Gumas, Megumi Shigematsu, Karin E. Borgmann-Winter, C. G. Hahn, Yohei Kirino

Computational Medicine Center Faculty Papers

Schizophrenia patients' olfactory epithelial cells contain abundant immune-activating tRNA fragments, linking small RNA biology to inflammation and suggesting avenues for diagnostics.

Aberrant Cd25 And Increased Cd123 Expression Are Common In Acute Myeloid Leukemia With Kmt2a Partial Tandem Duplication And Are Associated With Flt3 Internal Tandem Duplication, Qing Wei, Guilin Tang, Shaoying Li, Sa A Wang, Pei Lin, Wei Wang, Sanam Loghavi, Wei J Wang, L Jeffrey Medeiros, Jie Xu

Faculty, Staff and Student Publications

Background: KMT2A partial tandem duplication (PTD) occurs in approximately 5-10% of acute myeloid leukemia (AML) cases and is associated with poor prognosis. While its cytogenetic and molecular features are well described, the immunophenotypic characteristics of AML with KMT2A-PTD remain incompletely defined.

Methods: We identified 47 cases of AML with KMT2A-PTD by optical genome mapping. All cases underwent flow cytometric immunophenotypic analysis and next-generation sequencing using an 81-gene panel.

Results: The cohort included 32 men and 15 women with a median age of 67 years (range, 19-87). Thirty-eight cases were de novo AML, and nine were secondary to myelodysplastic …

Advances In Targeting Her2 Across Cancer Subtypes: A Pan-Tumor Approach, Taiwo Adesoye, Ecaterina E Dumbrava, Kanwal P S Raghav, Aysegul A Sahin, Hui Chen, Sunyoung S Lee, Milind M Javle, Shubham Pant, Omar Alhalabi, Xiuning Le, Vicente Valero, Paula R Pohlmann, Funda Meric-Bernstam

Faculty, Staff and Student Publications

Human epidermal growth factor receptor 2 (HER2) is an established therapeutic target in multiple solid tumors, particularly breast and gastric cancers. Significant advancements have been made in the development of HER2-targeted therapies, including monoclonal antibodies, tyrosine kinase inhibitors, antibody-drug conjugates (ADC), and novel bispecific antibodies. These agents have revolutionized the treatment landscape for HER2-positive metastatic cancers, resulting in improved progression-free and overall survival, and quality of life for patients. Beyond breast and gastric cancers, HER2 expression/amplification has been observed in other solid tumors, such as colorectal, lung, bladder, ovarian, and biliary tract cancers, offering new opportunities for personalized therapy in …

Role Of The Etv5/P38 Signaling Axis In Aggressive Thyroid Cancer Cells, Jerry H Houl, Rozita Bagheri-Yarmand, Muthusamy Kunnimalaiyaan, Paola Miranda Mendez, Joseph L Kidd, Ali Dadbin, Andrea Ruiz-Jurado, Parag A Parekh, Ying C Henderson, Nikhil S Chari, Aatish Thennavan, Reid T Powell, Clifford C Stephan, Xiao Zhao, Anastasios Maniakas, Roza Nurieva, Naifa L Busaidy, Maria E Cabanillas, Ramona Dadu, Mark Zafereo, Jennifer R Wang, Stephen Y Lai, Marie-Claude Hofmann

Faculty, Staff and Student Publications

Patients with poorly differentiated thyroid cancer (PDTC) and anaplastic thyroid cancer (ATC) face a much poorer prognosis than those with differentiated thyroid cancers. Around 25% of PDTCs and 35% of ATCs carry the BRAFV600E mutation, which constitutively activates the MAPK pathway, a key driver of cell growth. Although combining BRAF and MEK inhibitors can shrink tumors, resistance often develops. The exact cause of this resistance remains unclear. We previously found that in PDTC and ATC cells, the BRAFV600E mutation is strongly linked to the expression of ETV5, a transcription factor downstream of the MAPK pathway. In the current study, we …

Grow Your Own Microgreens, Stephen Beck

All Current Publications

This fact sheet reviews the steps and materials needed to grow microgreens, such as radish, broccoli, sunflower, or pea shoots. Microgreens are fast and easy to grow and a healthy addition to your diet.

Brain Gains: A Review Of Remediation Treatment Strategies Using Exercise Following Traumatic Brain Injury, Jessica Smith, Kristin Biggins, Loriann Helgeson

The Open Journal of Occupational Therapy

In this Opinions in the Profession article, we explore remediation treatment strategies using exercise for recovery from post-traumatic brain injury and aim to justify the use of such treatment in the occupational therapy profession to increase skills for functional gain. Common treatment strategies used by occupational therapists after brain injury are compensatory strategies, indicating the client learns a new way to perform the task. Though effective, it is also necessary to consider how remediation and neuroplasticity are essential. Teaching new approaches to complete tasks results in functional gains; however, focusing on foundational skills using exercises to relearn motor patterns to …

Probiotics Regulate Gut Microbiota And Immune Homeostasis To Prevent And Treat Food Allergy : A Review, Yao Chen, Zumeng Xia, Yijin Yang, Lianzhong Ai, Guangqiang Wang, Yan Zhang, Zhen Luo, Yong Zhou, Yongjun Xia

Journal of Food Science and Biotechnology

Food allergy (FA) is a common immunological disorder,and its pathogenesis is primarily associated with a complex regulatory process involving CD 4+ T cells in the immune system,such as the polarization of Th 2 cells and the imbalance between Treg/Th 17 cells.The balance of intestinal immune cells plays a critical role in the development of FA,while dysbiosis of the gut microbiota may disrupt this balance,thereby contributing to the onset of FA.Probiotic intervention targeting the gut microbiota can directly or indirectly influence the functions of immune cells to regulate immune responses,representing a promising approach for the prevention and treatment of FA.The authors …

Nitrogen Dynamics And Use Efficiency In Pasture-Based Grazing Systems: A Synthesis Of Ecological And Ruminant Nutrition Perspectives, Bashiri Iddy Muzzo

Wildland Resources Student Research

Pasture-based ruminant systems link nitrogen (N) nutrition with ecosystem N cycling. Grazing ruminants convert fibrous forages into milk and meat but excrete 65 to 80% of ingested N, creating excreta hotspots that drive ammonia volatilization, nitrate leaching, and nitrous oxide (N₂O) emissions. This review synthesizes ecological and ruminant nutrition evidence on N flows, emphasizing microbial processes, biological N₂ fixation, plant diversity, and urine patch biogeochemistry, and evaluates strategies to improve N use efficiency (NUE). We examine rumen N metabolism in relation to microbial protein synthesis, urea recycling, and dietary factors including crude protein concentration, energy supply, forage …

Why Agtech Startups Fail? Evidence From Global Shutdown Patterns In 2025 And The Cost-Adoption Mismatch Effect, Ankit Chandra, Ishani Lal

Department of Agricultural and Biological Systems Engineering: Presentations and White Papers

Agricultural technologies are widely seen as a driver for sustainability, resilience, and food-system transformation. Yet in 2025, agtech startup across North America, Europe, Asia, and Africa experienced multiple shutdowns. Although each company closed for its own reasons, the failures highlight consistent underlying patterns. We analyze 18 publicly reported shutdowns across controlled-environment agriculture (CEA), robotics, insect protein, digital platforms, sensors, and ag-biotechnology. We find that most ventures struggled not with scientific feasibility but with economic and adoption dynamics at the farm level. We identify a Cost-Adoption Mismatch Effect, in which the capital and operational burden of a technology exceeds farmers’ capacity …

Bridging Hypoxia And Vision Loss: The Emerging Role Of Connexins In Local And Systemic Eye Diseases, Xianping Zhang, Yalong Cheng, Jean X Jiang, Yuting Li

Faculty, Staff and Student Publications

Hypoxic eye diseases represent a pivotal yet often underappreciated contributor to the onset and progression of many retinal disorders. When hypoxia persists or exceeds the tissue's compensatory capacity, it triggers pathological retinal neovascularization, blood-retinal barrier disruption, and neuronal apoptosis, ultimately resulting in irreversible visual impairment. Connexins (Cxs) form gap junction channels and hemichannels and regulate retinal cell proliferation, differentiation, and survival, thereby playing a central regulatory role in the pathogenesis of hypoxic ocular diseases. In addition to gap junctions, Cx hemichannels promote transmission of molecules between intra- and extracellular environments, further influencing retinal homeostasis under hypoxic stress. This review synthesizes …

Bdcd: A Comprehensive Brain Disease Cell-Cell Communication Database, Xinyi Liu, Citu Citu, Gang Qu, Wendao Liu, Nitesh Enduru, Andi Liu, Chia-Hao Tung, Zhongming Zhao

Faculty, Staff and Student Publications

Dysregulated cell–cell communication (CCC) is increasingly recognized as a driver of brain disease pathology, contributing to neuroinflammation, synaptic dysfunction, and neurodegeneration. Nevertheless, existing resources remain limited in brain specificity, regional coverage, and functional annotation. To address this gap, we develop the Brain Disease Cell-cell communication Database (BDCD), the first comprehensive resource focused on CCC networks across major brain diseases. BDCD integrates 38 manually curated datasets, comprising 8 519 425 single cells from single-cell RNA-seq studies and 140 744 spots from spatial transcriptomic maps, spanning 14 brain regions and 13 canonical cell types covering Alzheimer’s disease, Parkinson’s disease, schizophrenia, bipolar disorder, …

Desert Plant Endophyte Genome Database: A Curated Repository Of Endophytic Bacterial Genomes Across Arid Ecosystems, Sabiha Parween, Arun Prasanna Nagarajan, Amal K. Alghamdi, Abdul Aziz Eida, Feras F. Lafi, Luma Albanna, Nida Salem, Barakat Abu-Irmaileh, Zaid A. Pirzada, Shahid Siddique, Ruben Garrido-Oter, Paul Schulze-Lefert, Maged M. Saad, Heribert Hirt

All Works

Microbial communities associated with desert plants play a pivotal role in enhancing host survival under extreme environmental stressors, including drought, salinity, and nutrient limitation. The Desert Plant Endophyte Microbial Collection is one of the largest curated repositories of 2500 cultivable endophytic bacteria isolated from 23 native desert plant species across Saudi Arabia, Jordan, and Pakistan. Representing a broad spectrum of arid microhabitats from inland deserts and mountain wadis to coastal mangroves and date palm oases, the collection supports integrative studies on microbial ecology and plant-microbe interactions in water-limited ecosystems. A central component of this initiative is the Desert Plant Endophyte …

Retention On Buprenorphine For Opioid Use Disorder In Justice-Involved Individuals: A Retrospective Cohort Study, Andrea Yatsco, Francine R Vega, Audrey Sarah Cohen, Marylou Cardenas-Turanzas, James R Langabeer, Tiffany Champagne-Langabeer

Faculty, Staff and Student Publications

Criminal justice system (CJS) involvement is common among individuals with opioid use disorder (OUD), yet limited research examines retention in medications for OUD (MOUD) within community settings. This study assessed whether CJS involvement predicted retention on buprenorphine/naloxone and explored related demographic and clinical factors. A retrospective cohort included adults (n = 367) enrolled in a low-barrier outpatient MOUD program in Texas (January 2022–April 2024). CJS involvement was identified from program records. Retention was measured as the number of continuous days with buprenorphine/naloxone prescriptions. Analyses used univariate tests, logistic regression, and nonparametric kernel regression. Nearly one-quarter (24.8%) were CJS-involved. Retention at …

A196: Prediction Of Cardiovascular Function Improvement Based On Wearable Device Motion Monitoring And Otnmanba-Bilstm Model, Yixuan Li, Lan Zheng

International Journal of Physical Activity and Health

Cardiovascular diseases are among the leading chronic health conditions worldwide, with prolonged physical inactivity or improper exercise increasing the risk of their occurrence. Existing studies suggest that well-structured exercise interventions can significantly enhance cardiac function and improve the adaptability of the cardiovascular system. However, accurately predicting the long-term impact of different exercise durations and intensities on heart health remains challenging due to individual physiological differences, exercise habits, and lifestyle factors. This study employs a data-driven approach to develop a predictive model based on wearable device motion monitoring data, aiming to elucidate the dynamic relationship between exercise and cardiovascular health and …

A197: Perceptual Behavior And Social Interaction Of Chinese College Students Toward Esports, Xianhua Luo

International Journal of Physical Activity and Health

Social exchange theory (SET) has been extensively used to recognize students’ perceptual behavior (PB) and social interaction (SI). Research has examined the potential factors of recognition and socialization against the economic factors in individual evaluation, seeking rewards or avoiding costs in relationships. The positive impact of PB and SI is a significant experimental approach to studying social psychology. Therefore, the processes of individuals’ perceptual behavior and their social interactions in Esports might address this research gap. Hence, the purposes of this study were to explain the PBs and SIs toward Esports among college students in China. Method: 341college students were …

A214: Effects Of Tai Chi And Brisk Walking On Sensation In Pn Elders, Qiongqiu Zhao, Qipeng Song

International Journal of Physical Activity and Health

Peripheral neuropathy (PN) is a prevalent neurological disorder, affecting 26–39.2% of adults aged 65 and older due to peripheral nerve degeneration and associated conditions like diabetes. PN leads to sensory impairments, including diminished tactile sensation, increased fall risk, and mobility issues. Tai Chi (TC) is a low-impact exercise shown to enhance sensory function and balance in healthy older adults, but its effects on PN patients remain unclear. Brisk walking (BW) is a widely recommended exercise for older adults, yet its impact on sensory function in PN is not well-established. This study compares TC and BW interventions on tactile sensation in …

Variances In Power Output Of Female Athletes During The Menstrual Phases, Julia L. Allen

Masters Theses

The purpose of this research was to examine if there are any variances in a female athlete’s ability to produce power, that could be correlated with the menstrual cycle phases. The study observed three elite female athletes throughout 13 weeks, collecting relative propulsive power and relative braking power data from their vertical jump performances which occurred multiple times a week. At the end of the 13 weeks, participating athletes were asked to download their personal Oura Ring data. The Oura data points included in this study were used to identify and measure several physiological factors such as menstrual cycle day, …

A Quantitative Analysis Examining The Impact Of Recreation Sports On The Overall Wellness Of Undergraduate Students At The University Of Louisiana At Lafayette, Kathryn "K-Lynn" Mckey

Doctoral Dissertations

The overarching question guiding this research study was, how does the use of university recreational sports facilities and resources impact reported wellness across the eight dimensions of wellness among undergraduate students? This study answered this question by examining literature, reviewing specific dimensions of wellness, and evaluating ways to determine if physical activity affects overall wellness for undergraduate students. According to the literature, approximately half of undergraduate students do not meet the daily recommendation for physical activity. Research suggests healthier students have greater retention rates, higher grade point averages (GPA), and demonstrate better mental health. To better support students’ needs, universities …

A088: Best Core Stability Training Program For Lower Limb Dysfunction In Stroke Patients: A Network Meta-Analysis, Kaiqi Zheng, Dan Wang, Guoliang Liang, Chunyun Deng

International Journal of Physical Activity and Health

Stroke is the third leading cause of disability and the second leading cause of death among adults. Lower limb dysfunction caused by stroke significantly impairs patients' quality of life. Numerous studies have demonstrated that core stability training (CST) can effectively improve lower limb function in stroke patients, and combining CST with other rehabilitation approaches may yield better therapeutic outcomes. This study aims to identify the most effective CST-based combined intervention for treating lower limb dysfunction in stroke patients. Method: Randomized controlled trials (RCTs) published up to July 22, 2024, were searched from PubMed, Embase, Cochrane Library, Web of Science, CNKI, …

A090: Development And Efficacy Evaluation Of Virtual Reality (Vr)-Based Personalized Exercise Prescriptions For Perimenopausal Women, Runze Zhu, Zekai Wu

International Journal of Physical Activity and Health

Perimenopausal women (aged 45–54) frequently experience climacteric symptoms such as vasomotor disturbances, osteoporosis, and cardiovascular risks due to declining ovarian function and estrogen levels. Approximately 75% of women report varying degrees of discomfort, with 80% exhibiting at least one symptom (e.g., sleep disorders, mood fluctuations). Conventional exercise prescriptions often lack specificity to address individual health disparities and comorbidities (e.g., osteoporosis, metabolic dysfunction). This study aimed to develop a virtual reality (VR)-based personalized exercise prescription system to enhance exercise adherence through immersive experiences and evaluate its efficacy in alleviating perimenopausal physiological and psychological symptoms. A personalized exercise prescription generation system was …