Digital Commons Network^™

Leo Ii...A Remembrance, The Flor-Ala

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A special edition issue of The Flor-Ala in remembrance of Leo II.

New Honor For Leo Ii: May Be First In Nation, Cheri Shipper, Dr. J. R. Holladay, Dr. Wayne Cotton

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This news release announces the exciting news that Leo II was selected as "Honorary ChairAnimal for National Pet Week" May 7-13 in the Shoals.

Tv Helps Leo Overcome Boredom, Karen Jackson

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TV always makes people (and animals) happy!

*Article from The TimesDaily*

See The Lion At Una, Vacation Guide

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A short write-up about the only African lion which serves as a school mascot-Leo II.

King Of The Jungle, Scott Burcham/Staff

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Leo II playing with his new toy pig on the eve of UNA's game against Texas A & M Kingsville in Florence.

Leo I Versus Leo Ii, Dr. Joe Wallace

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Personal account of Leo I versus Leo II written by Dr. Joe Wallace in Shoal Magazine.

Lion Talk: Vocabulary 101, Elise Cofield

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Information about the Lions Fund at the University of North Alabama in the Spring edition of the UNA Magazine.

Leo Ii's Passing Leaves Large Void Around Una Campus, Una Sports Information

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A fitting tribute to Leo II in the Lion's Roar.

The Story Of Leo The Lion, Joe Wallace

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This souvenir edition magazine details the relationship between author Joe Wallace and Leo I at UNA.

Watching Our Family Grow, Una Magazine

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A typical day for 10 months old Leo III and Una at the George H. Carroll Lion Habitat.

The Pride Of Una, Michelle Rupe Eubanks

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Fun facts about Leo III and Una.

Una's Leo Put To Sleep, Lori Allen Dendy

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Breaking the news that Leo I has passed away at 14 years old.

*Article from The TimesDaily. *

Leo Recalled With Fondness, Lori Allen Dendy

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Remembering Leo I.

*Article from The TimesDaily. *

College Mascot Dies, Montgomery Advertiser

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Write up from The Montgomery Advertiser about Leo I's passing.

Tv Time, Matt Mckean/Staff

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Blurb about the joy TV brings to Leo II in The TimesDaily.

Leo Ii Dies Of Heart Failure At Auburn, Office Of University Relations And Staff Reports

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News of Leo II's passing in The Flor-Ala.

Party Animal, Matt Mckean/Staff

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Leo II and kids from First United methodist Church daycare enjoy celebrating his birthday.

*Article from The TimesDaily*

Leo Ii...King Of Una, Steven Compton

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Shoals Magazine article on Leo II

Primary Membranoproliferative Glomerulonephritis: Natural History, Pathogenesis, And Treatment, Edward J. Filippone, John L. Farber

Division of Nephrology Faculty Papers

Primary membranoproliferative glomerulonephritis (MPGN) is an ultrarare disease characterized by immunofluorescence microscopy as either immune-complex mediated (IC-MPGN) or C3 glomerulopathy (C3), the latter subdivided by electron microscopy to C3 glomerulonephritis (C3GN) and dense deposit disease (DDD). Both IC-MPGN and C3G typically have obvious C3 staining differentiating them from other causes of MPGN histology. Secondary causes must be excluded, including infections, autoimmune disease, and neoplasia. Clinical presentations are variable, including urinary sediment abnormalities, nephrotic syndrome, or a rapidly progressive course. The prognosis is unfavorable with about 50% reaching kidney failure by 10 years. Recurrence following transplantation is frequent, and allograft survival …

Finding Research Datasets And Evaluating Data Quality, Ibis Anette Moreno-Lozano Phd.

Day Family Research Lab Workshop Series

No abstract provided.

Metagenomic Insights Into Antimicrobial Resistance In Small-Scale Poultry And Cattle Farms, Elijah Ayilaran, Agnes Kilonzo-Nthenge Agnes Kilonzo-Nthenge

Food and Animal Sciences Faculty Research

Antimicrobial resistance (AMR) poses a critical challenge to global health, with food animal production systems recognized as significant reservoirs of antimicrobial-resistant bacteria. This study evaluated the prevalence and distribution of antimicrobial resistance genes (ARGs) and virulence factors (VFs) across small-scale poultry and cattle farms. A total of 468 samples (soil, feces, water, and natural land soil) were collected from four farms and analyzed using shotgun metagenomics. Proteobacteria (34.91%) were the dominant phylum across environments, followed by Cyanobacteria (15.67%), Actinobacteria (14.95%), Firmicutes (10.57%), and Bacteroidetes (8.69%). Tetracycline (33.41%) and beta-lactam (30.30%) resistance genes were the most abundant, with macrolide (9.32%) and …

Stocks And Shocks: Assessing The Relative Roles Of Public And Private Inventories In Buffering Rice Price Volatility In The Philippines, Bernhard Dalheimer, Kenneth Foster, Gerald E. Shively, Valerien O. Pede, Dela-Dem Doe Fiankor, Jacob Ricker-Gilbert, Pratibha Bist

Department of Agricultural Economics Faculty Publications

Public stockholding of food is politically contentious and economically challenging. Although private stocks are generally understood to be more efficient than public stocks at providing a reliable buffer against production shortfalls, private stocks often fail to stabilize prices during extreme food market shocks. Moreover, maintaining large public stock programs in which the government acts as the buyer or seller of last resort, can be very costly. This paper analyzes the recent historical success of public and private rice stocks in stabilizing domestic rice prices in the Philippines, the world’s largest net importer of rice. Relying on competitive storage theory and …

Weight Loss Patterns And Clinical Outcomes Of Glp1 Receptor Agonists In Breast Cancer Survivors, Jasmine S Sukumar, Akshara Singareeka Raghavendra, Sarah Pasyar, Roland L Bassett, Debu Tripathy, Carlos H Barcenas, Karen M Basen-Engquist, Banu K Arun

Faculty, Staff and Student Publications

Use of glucagon-like peptide-1 receptor agonists (GLP1-RA) for weight loss is increasing; implications in breast cancer (BC) survivors remain unclear.This retrospective cohort study evaluated treatment patterns, weight loss, and outcomes in BC survivors at an academic institution receiving GLP1-RA. We evaluated patients with non-metastatic (ductal carcinoma in situ (DCIS), stage 1-3) BC who received GLP1-RA (2005 - 2024). Linear regression models estimated associations between weight change and clinical factors. After excluding DCIS, propensity score matching (1:2) was used to match patients who received GLP1-RA with patients who did not, based on confounding covariates. Kaplan-Meier estimates and log-rank tests compared disease-free …

Tumor-Immune-Neural Circuit Disrupts Energy Homeostasis In Cancer Cachexia, Xiuhui Shi, Alex X Arreola, Zhijun Zhou, Jingxuan Yang, Mingyang Liu, Yang Cai, Yu Ren, Hao Yuan, Qun Chen, Xinjie Chen, Xinyu Yang, Yimei Meng, Jingyi Wang, Wenyi Luo, Michael C Rudolph, Rohan Varshney, Kar-Ming Fung, Chao Xu, Wei R Chen, Michael S Bronze, Lei Zheng, Yi-Ping Li, Courtney W Houchen, Yuqing Zhang, Min Li

Faculty, Staff and Student Publications

Cancer-induced cachexia and anorexia are debilitating complications across many cancers, yet effective treatments remain limited due to a poor understanding of the underlying mechanisms. Here, we identify an uncharacterized tumor-immune-neural circuit driving these syndromes, centered on growth and differentiation factor 15 (GDF15). Using genetically engineered mouse models, we find that loss of GDF15 protects against appetite loss, muscle wasting, and fat loss in pancreatic, lung, and skin cancers. Single-cell RNA sequencing reveals macrophages as a major source of GDF15, induced by tumor-derived colony-stimulating factor 1 (CSF1). GDF15 acts via the central nervous system to enhance β-adrenergic signaling in the tumor …

Primary Tumor Size And Tumor-Vessel Interface Following Capecitabine And Temozolomide For Pancreatic Neuroendocrine Tumor, Jin Guo, Kever A Lewis, Laura Prakash, Priya Bhosale, Ajaykumar Morani, Matthew H G Katz, Ching-Wei D Tzeng, Naruhiko Ikoma, Rebecca Snyder, Michael P Kim, Chandrikha Chandrasekharan, Arvind Dasari, James C Yao, Jeffrey E Lee, Jessica E Maxwell, Daniel M Halperin

Faculty, Staff and Student Publications

Capecitabine/temozolomide (CAPTEM) is an established regimen for patients with metastatic pancreatic neuroendocrine tumors (PanNET) that is being increasingly used for tumor volume reduction in patients with borderline anatomically resectable disease. We sought to understand the response of the primary tumor, defined as changes in the tumor–vascular interface (TVI). This is a retrospective, single-institution study of patients with locally advanced or metastatic PanNET treated with CAPTEM between 2010 and 2020. RECISTv1.1 measurements and TVI assessments of the primary tumor were performed on pre- and post-therapy images. Patients with locally advanced or metastatic PanNET at presentation (n = 47) were included. …

Albumin-Binding Domains In Therapeutic Protein Engineering: A Structural And Computational Perspective On Rational Design, Matthew Argyle, Dallin M. Chipman, Anna Claire Woolley, Bradley C. Bundy, Dennis Della Corte

Faculty Publications

Therapeutic proteins face a critical pharmacokinetic challenge: rapid clearance from circulation limits their clinical efficacy. Albumin-binding domains (ABDs) offer an elegant solution by enabling therapeutic proteins to “hitchhike” on serum albumin’s favorable 19-day half-life through FcRn-mediated recycling. Clinical validation through approved therapeutics like ozoralizumab demonstrates the success of this approach, with preclinical studies showing fusion to an ABD extended half-life to 18 days. This review provides an analysis of ABD-fusion protein design, integrating structural biology, computational prediction, and rational engineering principles. We catalog the major classes of albumin-binding modalities, including bacterial three-helix bundle domains, engineered peptides, antibody-derived binders, and alternative …

Temporal Dynamics Of Irrigation Characteristics In South Carolina, Selvalakshmi Selvaraj, Jose O. Payero, Dana B. Turner

Journal of South Carolina Water Resources

Irrigation plays a vital role in stabilizing crop production under climatic variability in the southeastern United States. However, limited long-term empirical evidence exists on how irrigation practices, water sources, and energy demands have evolved in South Carolina. The aim of this study was to examine temporal changes in irrigation characteristics in South Carolina. The analysis utilized two decades (2003–2023) of data from the United States Department of Agriculture – National Agricultural Statistics Service, Irrigation and Water Management Surveys. Results showed a 65% increase in the number of irrigated farms and 260% expansion in irrigated acreage over the twenty-year period. Groundwater …

Waters At Risk: Preventive Methods Against Cyanobacteria Blooms In Rhode Island, Ryan Boline

CAFE Symposium 2026

This project analyzes the rise of cyanobacteria blooms in Rhode Island freshwater systems and identifies a policy gap in the state’s largely reactive management approach. Drawing on state reports and interviews with environmental experts, it highlights nutrient runoff, climate change, and limited public education as key drivers of bloom severity. To address this gap, I developed a prevention-focused public education poster designed for integration into existing state alert and outreach systems.

Mycobacteria Infection Induced Cascade Of Epigenetic Alterations Promote Training In Bystander Macrophages, Shah E. Jahan Gulzar Mr

Theses and Dissertations

Mycobacterium tuberculosis (Mtb) remodels host cell functions to support its intracellular persistence. While the effects of Mtb infection on infected macrophages are well characterized, responses of uninfected bystander cells in the same microenvironment remain poorly understood. Here, we show that Mtb infection triggers widespread epigenetic reprogramming not only in infected macrophages but also in neighbouring bystander cells. These bystander macrophages acquire active chromatin marks, exhibit distinct transcriptional changes, and display enhanced immune responsiveness, thereby increasing resistance to both homologous and heterologous infections. We identify interleukin-1 beta secreted by infected cells as a key mediator of this process. Functionally, trained bystander …

A Taxonomic Overview Of The Apodemia Mormo Complex From A Genomic Perspective, Jing Zhang, Qian Cong, Jinhui Shen, Leina Song, Nick V. Grishin

The Taxonomic Report of the International Lepidoptera Survey

Genomic analysis of the Apodemia mormo group (Riodinidae Grote, 1895 (1827)) specimens across the range from southwestern Canada through much of the western USA and northwestern Mexico, complemented by phenotypic examination and photographs of live individuals to inspect eye color, partitions the complex into eight species, one of which is proposed as new: Apodemia (Apodemia) apache Grishin, sp. n. (type locality in USA: Arizona, Apache Co.), and three elevated from subspecies of A. mejicanus: Apodemia (Apodemia) maxima (Weeks, 1891), stat. rest., Apodemia (Apodemia) deserti W. Barnes & McDunnough, 1918, stat. nov., and Apodemia ( …