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The Cost Of Getting To “No”: Cultural Evolution Of Community Psychology In Two Indiana Communities, Catherine Cullen, Megan Peek Dec 2025

The Cost Of Getting To “No”: Cultural Evolution Of Community Psychology In Two Indiana Communities, Catherine Cullen, Megan Peek

The Journal of Purdue Undergraduate Research

No abstract provided.


Systematic Review: Burnout In Health Care Professionals, Nicolas X. Tovar Dec 2025

Systematic Review: Burnout In Health Care Professionals, Nicolas X. Tovar

The Journal of Purdue Undergraduate Research

No abstract provided.


Effects Of Alcohol Exposure On Recognition Memory And Marble-Burying Tasks In Male And Female Aged Mice, Roma Kamat, Tori Burke Dec 2025

Effects Of Alcohol Exposure On Recognition Memory And Marble-Burying Tasks In Male And Female Aged Mice, Roma Kamat, Tori Burke

The Journal of Purdue Undergraduate Research

Alcohol consumption in aging humans is a risk factor for cognitive impairment. This experiment assessed the effects of binge-like alcohol drinking in aged mice on memory (using the object recognition memory [ORM] task) and on anxiety-and compulsive-like behavior (using the marble-burying task). Subjects were 8 female and 10 male mice, 14–15 months old, selectively bred for low alcohol preference (LAP). Mice consumed either tap water or a 20% alcohol (v/v) solution in tap water through a drinking in the dark (DID) procedure for 4 consecutive days per week, for 3 consecutive weeks. One and 11 days after DID, mice completed …


Butterflies & You: Considerations Of Human Relationships With The Natural World, M. E. Colby Dec 2025

Butterflies & You: Considerations Of Human Relationships With The Natural World, M. E. Colby

Undergraduate Honors Theses

Science communication only accounts for approximately 2% of the entire scientific output of 2017-2022 (Parejo-Cuéllar et. al, 2024). It is an under-researched and under-valued field, especially in an age that has devalued science as a whole. The delicate art of explaining complicated ideas to people who are unfamiliar with scientific jargon is vital to humans’ understanding of the world. Butterflies & You is a documentary film exploring the relationship between humans and the many different butterfly species that call Illinois home. Video-based science communication is important to research and practice because of its impact on environmental advocacy and the growing …


Exposures, Protections, And Barriers: Advancing Understanding Of Agricultural Worker Health, Alexandra A. Farfalla Dec 2025

Exposures, Protections, And Barriers: Advancing Understanding Of Agricultural Worker Health, Alexandra A. Farfalla

Theses & Dissertations

Farming is a hazardous occupation. Exposures are multifactorial, variable, and shaped by overlapping tasks, environments, and social contexts. This dissertation aimed to illustrate the complexity of agricultural exposures and the barriers to protective practices through three complementary studies.

The first study examined co-exposures to solvents and noise as risk factors for hearing loss (HL) among 7,495 farmers and ranchers in a 7-state region. Results indicated nearly 60% of co-exposed participants reported hearing loss, with an adjusted odds ratio nearly six-fold (OR=6.03, [4.67-7.78]) for moderate/severe HL. This work highlights the importance of recognizing chemical exposures as a modality in HL in …


Public Perception About Covid-19 Vaccine Hesitancy In South Central Nebraska, Rita Nnenne Oparaocha Dec 2025

Public Perception About Covid-19 Vaccine Hesitancy In South Central Nebraska, Rita Nnenne Oparaocha

Biology Theses, Dissertations, and Student Creative Activity

The COVID-19 pandemic created a shift in the trajectory of vaccination hesitancy, altering risk perceptions and vaccination attitudes among individuals in rural communities. The 5C framework highlights confidence, complacency, constraints, calculation, and collective responsibility as influencing factors of vaccine hesitancy. This study assessed the proportion of adults who refused COVID-19 vaccination and identified the individual reasons for hesitancy among those who refused the COVID -19 vaccines in South Central Nebraska. Data was analyzed from a local cross-sectional public health survey administered to 2,034 adult participants over a six-month period (March-August 2024), including 91 respondents who were from outside the seven-county …


Investigating The Effects Of Body Composition Assessment On Dietary Intake In Division I Football Players, Cameron Nill, Nicole Dicicco Dec 2025

Investigating The Effects Of Body Composition Assessment On Dietary Intake In Division I Football Players, Cameron Nill, Nicole Dicicco

Student Scholar Symposium

No abstract provided.


Examining The Relationship Between Gambling Advertising & Gambling Behavior, Ilkim Green, Eric Wickenhauser, Hannah White Ph.D Dec 2025

Examining The Relationship Between Gambling Advertising & Gambling Behavior, Ilkim Green, Eric Wickenhauser, Hannah White Ph.D

Undergraduate Research Symposium

Gambling advertising has become increasingly prevalent across various media platforms such as TV, social media, real-life advertising, etc. With advertisements designed to influence attitudes, intentions, and behaviors of potential and existing consumers, this review aims to compile existing research to examine the measurable effects of gambling advertising. Studies indicate that young people and problem gamblers are especially vulnerable to these advertisements, which normalize gambling and contribute to increases in gambling behavior. This effect on behavior is dose-dependent; increased exposure to advertising is associated with greater gambling engagement. While responsible gambling messages are often included in advertisements, they remain largely ineffective …


Face Value: A Computational Approach To Subjective Impressions Of Faces, Kevin Kpankou Dec 2025

Face Value: A Computational Approach To Subjective Impressions Of Faces, Kevin Kpankou

Undergraduate Research Symposium

Various computational models of first impressions have been developed to uncover the mechanisms driving these judgments. However, the implicit notion of a singular ``human'' often overlooks meaningful individual differences in beliefs, attitudes, and associations, as well as culturally grounded group-level constructs. In this paper, we extend Cultural Consensus Theory (CCT) to estimate culturally shared beliefs about faces by incorporating latent constructs structured around interpretable facial features extracted via computer vision algorithms. We apply our model to a large-scale dataset of people’s first impressions of faces. Our approach reveals a robust mapping between facial features and culturally constructed impressions, allowing us …


Determination Of Serum Cortisol Levels As A Stress Marker In Hospitalized Dogs, Emre Tüfekçi̇, Gencay Eki̇nci̇, İlknur Karaca Bekdi̇k, Ali̇ Cesur Onmaz, Öznur Aslan, Vehbi̇ Güneş, İhsan Keleş, Mehmet Çi̇ti̇l Dec 2025

Determination Of Serum Cortisol Levels As A Stress Marker In Hospitalized Dogs, Emre Tüfekçi̇, Gencay Eki̇nci̇, İlknur Karaca Bekdi̇k, Ali̇ Cesur Onmaz, Öznur Aslan, Vehbi̇ Güneş, İhsan Keleş, Mehmet Çi̇ti̇l

Turkish Journal of Veterinary & Animal Sciences

In veterinary medicine, various diseases and surgical procedures may require the isolation and hospitalization of dogs, allowing for more effective individual patient monitoring and increasing the chance of successful treatment by preventing unnecessary drug use. However, this process can be stressful. Our study aimed to determine the changes in cortisol levels, one of the primary stress hormones responsible for stress responses, in individually hospitalized dogs. In addition, epinephrine (EPN) levels, another stress marker, as well as hematological and some biochemical values were measured and vital signs were recorded. The dogs included in the study were divided into 3 groups: healthy, …


The Role Of Attention And Design In The Effectiveness Of Eco-Feedback Systems, Lyndsey Bentzoni Dec 2025

The Role Of Attention And Design In The Effectiveness Of Eco-Feedback Systems, Lyndsey Bentzoni

Best Integrated Writing

This paper examines the role of eco-feedback systems in promoting pro-environmental behaviors by providing users with easily accessible information about their resource consumption. While these systems have shown potential to reduce consumption, they can face difficulties in maintaining user engagement and achieving long-term behavior change. There are several key factors related to the design of feedback interfaces that influence the effectiveness of eco-feedback systems. Gamification has been proposed as an effective way to enhance user engagement but requires careful design to connect behaviors from the digital to the real space for learning transfer. Research on the long-term usage of these …


Best Integrated Writing Fall 2025 - Complete Edition, Wright State University School Of Humanities And Cultural Studies, Tracy Smith, Kristie Mckiernan Dec 2025

Best Integrated Writing Fall 2025 - Complete Edition, Wright State University School Of Humanities And Cultural Studies, Tracy Smith, Kristie Mckiernan

Best Integrated Writing

Best Integrated Writing includes excellent student writing from Integrated Writing courses taught at Wright State University.


Homemade For Change: Addressing The Barriers To Home Cooking Among Emerging Adults For Better Health, Finances, And Well-Being, Sarida Smitthimedhin Dec 2025

Homemade For Change: Addressing The Barriers To Home Cooking Among Emerging Adults For Better Health, Finances, And Well-Being, Sarida Smitthimedhin

Masters Theses

This study investigates how a visual approach—combining design, photography, and illustration with nutrition—can encourage home cooking. In today’s fast-paced society and overabundance food culture, many emerging adults struggle to prepare meals at home. This study examines how food industry practices and cultural trends shape the eating habits of emerging adults by exploring the reasons behind the decline in home cooking and its adverse effects on health, finances, well-being, and the environment.

Although research indicates that most adults recognize that home cooking is the healthiest choice, they often do not practice it, citing time and lack of cooking knowledge as their …


Effects Of Chamomile And L-Theanine Beverage On Menstrual Pain, Menstrual Symptoms, Mood, And Sleep Quality In Young Women Experiencing Primary Dysmenorrhea: A Randomized, Double-Blind, Placebo-Controlled Study, Ziqing Soh, Soo Cing Tan, Tak Hiong Wong, Seok Tyug Tan, Seok Shin Tan, Chin Xuan Tan Dec 2025

Effects Of Chamomile And L-Theanine Beverage On Menstrual Pain, Menstrual Symptoms, Mood, And Sleep Quality In Young Women Experiencing Primary Dysmenorrhea: A Randomized, Double-Blind, Placebo-Controlled Study, Ziqing Soh, Soo Cing Tan, Tak Hiong Wong, Seok Tyug Tan, Seok Shin Tan, Chin Xuan Tan

Journal of Food and Drug Analysis

Primary dysmenorrhea is one of the most common complaints among young women. This study aimed to evaluate the effects of chamomile and L-theanine beverage intake on menstrual symptoms, pain intensity, mood, and sleep quality in young adult females with primary dysmenorrhea, using a two-phase continuous study design. In the first phase, a cross-sectional study was conducted to assess the prevalence of primary dysmenorrhea. In the second phase, participants were randomly assigned to either the intervention group (n =15), which consumed chamomile and L- theanine beverage (CTT), or the control group (n =15), which consumed chamomile-flavored beverage (non-CTT). Beverages …


Knowledge, Attitudes, And Practices Concerning Water, Sanitation, And Hygiene And Related Diseases Among University Students In Malaysia, Renee Ng Jeffrey, Aida Soraya Shamsuddin, Farah Diyana Ariffin, Aziemah Zulkifli Dec 2025

Knowledge, Attitudes, And Practices Concerning Water, Sanitation, And Hygiene And Related Diseases Among University Students In Malaysia, Renee Ng Jeffrey, Aida Soraya Shamsuddin, Farah Diyana Ariffin, Aziemah Zulkifli

Makara Journal of Health Research

Background: Water, sanitation, and hygiene (WASH) practices are fundamental components of public health, being crucial in preventing disease transmission and promoting healthy living environments. In this context, university students play an essential role as future professionals and community advocates in fostering proper hygiene behaviors and preventing disease outbreaks. Understanding knowledge, attitudes, and practices (KAP) in regard to WASH among individuals, particularly university students, is crucial for promoting proper hygiene behaviors. This study aimed to assess the KAP in regard to WASH and related diseases among undergraduate students from the Faculty of Health Sciences, Universiti Kebangsaan Malaysia (UKM).

Methods: …


Acute And Chronic Effects Of Neuroinflammation On Hippocampus And Anterior Cingulate Cortex Network Dynamics, Lauren A. Crew Dec 2025

Acute And Chronic Effects Of Neuroinflammation On Hippocampus And Anterior Cingulate Cortex Network Dynamics, Lauren A. Crew

UNLV Theses, Dissertations, Professional Papers, and Capstones

Neuroinflammation has emerged as a critical modulator of cognitive function and neural circuit dynamics, yet the distinct contributions of acute and chronic neuroinflammation to brain function remain poorly defined. This dissertation examines how inflammation independently alters large-scale neural activity and behavior, focusing on interactions between the hippocampus (HPC) and anterior cingulate cortex (ACC), regions essential for memory and executive processes. Using in vivo electrophysiological techniques in a rodent model, this study compares the effects of short-term (acute) and prolonged (chronic) neuroinflammatory states, induced via Poly I:C, on neural oscillations, regional coherence, and spatial coding. Findings reveal that even transient inflammation …


Modeling The Mojave: A Multiphase, Mixed Methods Phenomenological Investigation Of Novice Understanding Of A Complex Ecological System, Nicole Juliana Thomas Dec 2025

Modeling The Mojave: A Multiphase, Mixed Methods Phenomenological Investigation Of Novice Understanding Of A Complex Ecological System, Nicole Juliana Thomas

UNLV Theses, Dissertations, Professional Papers, and Capstones

This research explores early college science majors’ conceptions of the Mojave Desert ecosystem as a complex system. A multi-level, explanatory sequential mixed methods design was employed to study college science majors’ understanding of the Mojave Desert ecosystem to better inform science pedagogy. The first level, the quantitative phase of the study, consisted of developing a mathematical representation of twelve ecosystem variables present within the Mojave Desert. The second level, the qualitative phase of the study, consisted of phenomenological semi-structured interviews with 23 early college science majors. The findings of this research suggest that the Mojave Desert operates as a complex, …


Neurobehavioral Mechanisms Of Psychotic-Like Experiences And Cannabis Use, Ethan Campbell Dec 2025

Neurobehavioral Mechanisms Of Psychotic-Like Experiences And Cannabis Use, Ethan Campbell

Psychology ETDs

As cannabis use has increased steadily over the past decade, there is critical need to evaluate early cannabis use as a potential risk factor for the development of psychosis. Neurobehavioral mechanisms underlying novelty salience could clarify how cannabis exposure may influence subclinical psychotic-like experiences (PLEs). The present study leveraged dynamic functional connectivity and task-fMRI to assess the role of novelty processing in cannabis use and PLEs. A group of brain regions dynamically tied to the salience network while viewing short films were found to increase their activation as a function of stimulus novelty during a novelty bandit task. PLEs were …


Stress During Adolescence: A Characterization Of Anxiety-Like Behavior, And The Mrna Expression Of Neuroimmune Factors, Clock And Stress Genes In Corticolimbic Areas., Annette Fernandez Oropeza, Annette K. Fernandez Oropeza Dec 2025

Stress During Adolescence: A Characterization Of Anxiety-Like Behavior, And The Mrna Expression Of Neuroimmune Factors, Clock And Stress Genes In Corticolimbic Areas., Annette Fernandez Oropeza, Annette K. Fernandez Oropeza

Biomedical Sciences ETDs

Adolescence represents a critical window of frontal cortex (FC) maturation and corticolimbic circuit refinement that supports stress and emotion regulation. Disruption of these processes by early-life insults such as prenatal alcohol exposure (PAE) or adolescent stress increases vulnerability to anxiety and mood disorders, in part through circadian–immune dysregulation. The circadian transcription factor Bmal1 and the proinflammatory cytokine tumor necrosis factor-alpha (TNFα) have emerged as key regulators of neuroimmune signaling and synaptic communication, yet their interactions across developmental risk contexts remain poorly understood. This dissertation examined the effects of mild adolescent isolation stress, with and without PAE, on anxiety-like behaviors and …


Mental Health Literacy In Biology Graduate Teaching Assistants: Perception, Knowledge, And Training Needs In College Stem Education, Kanza Arshad, Ricardo Montoya, Nicole Scheuermann, Heather E. Bergan-Roller Dec 2025

Mental Health Literacy In Biology Graduate Teaching Assistants: Perception, Knowledge, And Training Needs In College Stem Education, Kanza Arshad, Ricardo Montoya, Nicole Scheuermann, Heather E. Bergan-Roller

Honors Capstones

College students experience a high prevalence of mental health challenges, and STEM students exhibit lower mental health literacy than students in other disciplines. Graduate Teaching Assistants (GTAs) play a crucial role in supporting undergraduate students, yet little is known about their mental health literacy (MHL) or how they navigate student disclosures in instructional settings. This preliminary study examines MHL among GTAs in biology, as well as their knowledge, perceptions, and training needs regarding MHL. We used semi-structured interviews and thematic analysis to examine how biology GTAs understand mental health, their responsibility related to student well-being, and what supports they identify …


Application Of Augmented Reality Technology As A Dietary Monitoring And Control Measure Among Adults: A Systematic Review, Gabrielle Victoria Gonzalez, Bingjing Mao, Ruxin Wang, Wen Liu, Chen Wang, Tung Sung Tseng Dec 2025

Application Of Augmented Reality Technology As A Dietary Monitoring And Control Measure Among Adults: A Systematic Review, Gabrielle Victoria Gonzalez, Bingjing Mao, Ruxin Wang, Wen Liu, Chen Wang, Tung Sung Tseng

School of Public Health Faculty Publications

Background/Objectives: Traditional dietary monitoring methods such as 24 h recalls rely on self-report, leading to recall bias and underreporting. Similarly, dietary control approaches, including portion control and calorie restriction, depend on user accuracy and consistency. Augmented reality (AR) offers a promising alternative for improving dietary monitoring and control by enhancing engagement, feedback accuracy, and user learning. This systematic review aimed to examine how AR technologies are implemented to support dietary monitoring and control and to evaluate their usability and effectiveness among adults. Methods: A systematic search of PubMed, CINAHL, and Embase identified studies published between 2000 and 2025 that evaluated …


Sex Disparities In Prescription Opioids Associated Cardiovascular Adverse Events, Li Ma Dec 2025

Sex Disparities In Prescription Opioids Associated Cardiovascular Adverse Events, Li Ma

Theses and Dissertations

The opioid crisis in the United States has evolved from a medical response to pain into a nationwide public health emergency. The prescription opioids (POs) – associated cardiovascular adverse events (CVAEs) remain insufficiently studied, especially in relation to sex disparities. This dissertation investigates sex disparities in PO-associated cardiovascular adverse events (CVAEs) through an analytic framework integrating artificial-intelligence-assisted literature mining and real-world pharmacovigilance analytics. In the analytic framework, first, AI powered topic modeling was employed to uncover POs-associated CVAEs risks with a focus on sex differences. A total of 1,837 PubMed abstracts were analyzed using two methods, Latent Dirichlet Allocation (LDA) …


Knee Injury Prevention Program In An Early Pubertal Female Athlete During A Recreational Softball Season, Doug W. Dendy, Toby Brooks, C Roger James, Micah Lierly Dec 2025

Knee Injury Prevention Program In An Early Pubertal Female Athlete During A Recreational Softball Season, Doug W. Dendy, Toby Brooks, C Roger James, Micah Lierly

Topics in Exercise Science and Kinesiology

Topics in Exercise Science and Kinesiology Volume 6: Issue 1, Article 12, 2025. This case study was intended to analyze the impact of a knee injury prevention program (KIPP) for a young female athlete in a short recreational softball season. It was hypothesized that initiating a KIPP early within a recreational sports season would positively alter lower extremity biomechanics, subsequently reducing the risk of knee injuries during and after skeletal development. During a recreational softball season, a 13-year-old female athlete completed a preliminary biomechanical test, the drop vertical jump battery (DVJBpre), underwent a 7-week in-season KIPP, then was …


Time Series Modeling Of Land Use And Land Cover Classification Using Remote Sensing, Ahmed A. F. Abd El Hamed, Fawzi H. Zarzoura, Mahmoud El-Mewafi Dec 2025

Time Series Modeling Of Land Use And Land Cover Classification Using Remote Sensing, Ahmed A. F. Abd El Hamed, Fawzi H. Zarzoura, Mahmoud El-Mewafi

Mansoura Engineering Journal

Understanding land use / land cover changes is essential for planning sustainable development. It represents the transformation of the land due to human activities, which is related to sustainable development that aims to achieve the needs of the present generations without affecting the future. Land use / Land cover is studied in Al Alamein region, northern Egypt, with supervised classification methods using satellite images from Landsat 8 and Sentinel - 2A in 2023 and analyzes the accuracy assessment, which shows Maximum likelihood is better in both sensors achieving overall accuracy (91.80% and 91.02%) and kappa coefficient (0.814 and 0.8799). Then …


Book Of Abstracts, Seton Hall University Dec 2025

Book Of Abstracts, Seton Hall University

2025 Augustine Undergraduate Research Symposium

No abstract provided.


The Need To Incorporate Polysubstance Use In Neuropsychopharmacology Research: Biological Lessons And New Opportunities, Max E. Joffe, Susan M. Ferguson, Nick W. Gilpin, Melissa A. Herman, Lori A. Knackstedt, Patrick A. Randall, Abigail G. Schindler, Mary M. Torregrossa, Jennifer A. Rinker Dec 2025

The Need To Incorporate Polysubstance Use In Neuropsychopharmacology Research: Biological Lessons And New Opportunities, Max E. Joffe, Susan M. Ferguson, Nick W. Gilpin, Melissa A. Herman, Lori A. Knackstedt, Patrick A. Randall, Abigail G. Schindler, Mary M. Torregrossa, Jennifer A. Rinker

School of Medicine Faculty Publications

Critical evaluation and refinement of animal models is essential for neuroscientists to understand complex physiological and pathological processes related to psychiatric diseases. In general, preclinical studies modeling drug dependence and problematic substance use have been limited to the administration of a single substance; however, there is a growing appreciation that this approach has failed to capture the complexities of humans and has stifled translational efforts. Polysubstance use represents the overwhelmingly common patterns of alcohol and drug use in humans. For example, epidemiological studies generally determine that between 70–95 % of individuals with alcohol use disorder use tobacco daily, and upwards …


The Timing Of Pubertal Onset Affects Adults Anxiety Behavior In A Sex-Specific Manner, Evan Raubenolt Dec 2025

The Timing Of Pubertal Onset Affects Adults Anxiety Behavior In A Sex-Specific Manner, Evan Raubenolt

Honors Projects

This study aims to look at the relationship between the timing of pubertal onset and its long-term effects on adult anxiety behavior in rats. Though the topic of pubertal onset has been frequently discussed in developmental research, its exact effects have been inconsistent. Human models have shown that early and late maturing males are associated with a notable increase in adult anxiety behavior, while in rat models, similar sex-specific effects regarding anxiety have been demonstrated, though those studies focus on a causal relationship between exposure to stress and age of pubertal onset. This study first aims to examine that relationship …


Space Agriculture: A Comprehensive Systems-Level Review Of Challenges And Opportunities, Hassan Fazayeli, Aaron Lee M. Daigh, Cassandra Palmer, Santosh Pitla, David Jones, Yufeng Ge Dec 2025

Space Agriculture: A Comprehensive Systems-Level Review Of Challenges And Opportunities, Hassan Fazayeli, Aaron Lee M. Daigh, Cassandra Palmer, Santosh Pitla, David Jones, Yufeng Ge

Biological Engineering Faculty Publications

As humanity prepares for prolonged space missions and future extraterrestrial settlements, developing reliable and resilient food-production systems is becoming a critical priority. Space agriculture, the cultivation of plants beyond Earth (particularly on the Moon and Mars), faces a constellation of interdependent environmental, biological, and engineering challenges. These include limited solar radiation, elevated ionizing radiation, large thermal variability, non-Earth atmospheric pressures, reduced gravity, regolith substrates with low nutrient-holding capacity, high-CO2/low-O2 atmospheres, pervasive dust, constrained water and nutrient availability, altered plant physiology, and the overarching need for closed-loop, resource-efficient systems. These stressors create an exceptionally challenging environment for plant …


Investigating Factors That Affect Total Ige Antibody Levels Of A Canine Population In Louisville, Ky, Iris N. Gillespie Dec 2025

Investigating Factors That Affect Total Ige Antibody Levels Of A Canine Population In Louisville, Ky, Iris N. Gillespie

Undergraduate Theses

Canine atopic dermatitis (CAD) is a genetically predisposed condition that causes inflammatory and pruritic (itchy) skin reactions in response to environmental and food allergens. The main purpose of this study is to determine if there is a correlation between pollen counts and total canine IgE antibody levels of dogs living in Louisville, KY. Additionally, data is analyzed to look for trends documented in previous studies related to the impacts of sex, age, and allergic symptoms on total IgE count. In collaboration with the Downtown Animal Hospital, blood samples were drawn from 16 dogs at one point in February (when pollen …


Health-Related Quality Of Life In The Era Of Immune Checkpoint Blockade: What Do Patient-Reported Outcomes Reveal?, Alexandra M Dunker, Neha Malik, Kathryn J Krause, Emily Z Keung, Jason B Liu, Elise F Nassif Haddad, Neeta Somaiah, Heather G Lyu, Christina L Roland Dec 2025

Health-Related Quality Of Life In The Era Of Immune Checkpoint Blockade: What Do Patient-Reported Outcomes Reveal?, Alexandra M Dunker, Neha Malik, Kathryn J Krause, Emily Z Keung, Jason B Liu, Elise F Nassif Haddad, Neeta Somaiah, Heather G Lyu, Christina L Roland

Faculty, Staff and Student Publications

Background: Immune checkpoint inhibitors (ICIs) have revolutionized cancer treatment by providing durable survival gains, but understanding their effects on patient health-related quality of life (HRQL) is critical.

Methods: We performed a narrative review of cross-sectional surveys, early-phase trials, and large-scale phase II and III randomized controlled clinical trials assessing FDA-approved ICIs, including programmed cell death protein 1 (PD-1) inhibitors, programmed death ligand 1 (PD-L1) inhibitors, and cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) inhibitors, with emphasis on patient-reported HRQL. Validated HRQL instruments were summarized, and for pivotal trials, the positioning of HRQL outcomes as primary, secondary, or exploratory endpoints was taken …