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Effects Of Hyperglycemia In Cognition And Sex, Erin E. Mcdonald

Senior Honors Theses

An empirical study tested the effects of Type 1 Diabetes (T1D) on cognitive function in a hyperglycemic mouse model. Strong correlations between mental illnesses, such as major depressive disorder, neuropathologies like Alzheimer’s disease, and diabetes suggest comorbid pathology. Considering the prevalence of both T1D and cognitive decline within the general population, the findings were relevant and aimed to identify early signs of cognitive decline in diabetic patients. Behavioral tests and immunohistochemical staining were utilized to determine the cognitive function of the mice, revealing decline or deterioration caused by hyperglycemia. Data gathered from the hyperglycemic or control mice were analyzed based …

Volume 16, Maggie Duncan, Madeline Little, Alicia Hoffman, Megan Livesay, Gabrielle Quaresma, Serenity Allen, Laina Pfountz, Ainslie Allred, Sabrina Robles, Nicholas J. Duellman, Trinity L. Deguzman, Melissa H. Savage, Margaret Dudley, Jocelyn Escobar, Olivia Hildreth, Olivia Hopkins, Benjamin Gettier, Lee Kassay, Jade Riddle, Ashley Seiders

Incite: The Journal of Undergraduate Scholarship

Introduction Dr. Amorette Barber, Director, Office of Student Research

From the Editor Dr. Hannah Dudley-Shotwell

Artist’s Statement Maggie Duncan

On Mentoring Dr. Lee Millar Bidwell

The Hujum Campaign in Uzbekistan and its Consequences by Madeline Little

Wet Cupping Compared to Dry Needling for Treatment of Patients with Low Back Pain: A Critically Appraised Topic by Alicia Hoffman and Megan Livesay

Optimization of eDNA Air Sampling Via 3D Printed Fan by Gabrielle Quaresma

Beyond the Classroom: A Qualitative Study of Teacher Attrition and Retention by Serenity Allen and Laina Pfountz

The Treatment of Subacromial Impingement Syndrome with Platelet-Rich plasma Injections Verses …

Discovery, Purification And Annotation Of Four Novel Mycobacteriophages In New England, Mason Krawczynski

Chemistry & Biochemistry Student Scholarship

Mason Krawczynski ’26, Biology and Psychology major

Faculty mentor: Dr. Kathleen Cornely, Chemistry and Biochemistry

Mycobacteriophages are viruses that infect bacteria of the Mycobacterium genus. Several thousand mycobacteriophages have been discovered, isolated, and characterized to advance the current understanding of their genomic diversity. The mycobacterium phage selection proves valuable, as they have a broad host range and potential for therapeutic application to treat pathogenic and antibiotic-resistant mycobacteria, such as Mycobacterium tuberculosis, the causative agent of tuberculosis infection. Kraw was isolated from a soil sample collected in Oaks Bluff, Massachusetts, on the island of Martha’s Vineyard in July 2023. FairyPath, Calvinny, …

Anxiety- And Compulsivity-Linked Differences In Reinforcement Learning In A Choose-Your-Own-Adventure Game, Tessa Medeiros

Neuroscience Program Student Scholarship

Tessa Medeiros ’26, Biology & Psychology major

Faculty mentor: Dr. Andra Geana, Psychology and Neuroscience

Reinforcement learning (RL) mathematically describes how agents learn to maximize the reward of their environment by understanding and comparing their choice options. This project investigates how anxiety and compulsivity impact the selection of these options and to what extent a text-based, narrative (rather than a game-like environment) changes RL processes in humans.

Not Human Enough: The Origins Of The Uncanny Valley, Franklin Young

Osmosis Magazine

Why do we feel creeped out when we see something almost human—like a lifelike robot or a bad CGI character? This phenomenon, known as the uncanny valley, describes the uncomfortable emotional response humans experience when encountering entities that appear nearly, but not quite, human. First introduced by Japanese robotics professor Masahiro Mori in 1970, the concept suggests that as objects become more humanlike in appearance, our emotional response to them becomes increasingly positive —until reaching a point where subtle imperfections trigger strong feelings of revulsion.

Letter From The Editor, Sam Chanenson

Osmosis Magazine

Letter from Sam Chanenson, Editor in Chief, Osmosis Science Magazine.

Osmosis Magazine - Science Magazine

Osmosis Magazine

• Explore the latest stories in STEM.
• Discover cutting-edge innovations shaping today & tomorrow
• Faculty Interview & UR Research Highlights

Evidence-Based Alternative Pain Management Techniques For Chronic Pain, Alise Williams Condie, Ashley Yaugher, Kira Swensen, Maren Wright Voss

All Current Publications

Chronic pain and opioid use have become topics of importance as opioid overdose deaths have risen to epidemic proportions throughout the nation. Chronic pain lasts for long periods of time and can be caused by a past injury or have no known cause. Opioids have been utilized to treat pain in the past, but it has been discovered that opioids are better used to treat acute pain and not chronic pain. Opioids can have negative consequences including changes to the brain, depression, increased pain, constipation, sedation, and even death. This fact sheet reviews and explains some of the most successful …

Relationships Between Performance In The Frequency Speed Kick Test, Heart Rate Variability, And Body Composition In Amateur Muay Thai Fighters, Antonio Beira De Andrade Junior, Elena Marie Peixoto Ruthes De Andrade, Patrícia Dos Santos Vigário, Cesar Antonio Luchesa, João Eduardo De Azevedo Vieira, Igor Ramathur Telles De Jesus, Agnaldo Jose Lopes

International Journal of Exercise Science

International Journal of Exercise Science 18(6): 428-442, 2025. In martial arts, heart rate variability (HRV) measurements can potentially be used to assess injury risk and susceptibility to fatigue. Muay Thai uses the Frequency Speed of Kick Test (FSKT) to measure kick speed, but it is unknown whether better fitness results in improved autonomic function and body composition, which may affect athletic performance and recovery. We aimed to evaluate the correlations between FSKT, HRV, and body composition measures in amateur Muay Thai fighters. This is a cross-sectional study with 37 Muay Thai fighters. They underwent FSKT-10s and multiple FSKT to measure …

Lack Of Patient-Centered Care Relative To Evidence-Based Practice In Clinical Diagnosis And Treatment Of Endometriosis In The U.S.: A Review, Piper E. Scoskie

Honors Theses

This scoping review examines the impact of combining Patient-Centered Care (PCC) and Evidence-Based Care (EBC) on clinical outcomes and patient satisfaction in the diagnosis and treatment of endometriosis in the United States. In particular, the review aims to (1) examine the body of research from the United States to learn more about the connection between PCC and EBC and their collective impact on patient satisfaction and clinical outcomes in the treatment of endometriosis; (2) identify the gaps in existing research and practice, specifically regarding PCC procedures, varying patient populations, and longitudinal investigations; and (3) provide recommendation for future research and …

The Effect Of Lithium On Intracellular Myo-Inositol Levels In Human Lymphoblasts Of Bipolar Disorder Patients, Ntakirutimana Francine

Honors Theses

Bipolar disorder is a chronic disorder characterized by mood swings of mania and depression. Bipolar I is characterized by intense mania, while bipolar II is characterized by hypomania and depression. Currently, there is no cure for bipolar disorder; however, one mainstay of treatment is lithium, which is hypothesized to alleviate symptoms by reducing myo-inositol.

In this study, the effect of lithium on intracellular myo-inositol was determined in lymphoblasts derived from bipolar disorder patients and compared to that of lymphoblasts from a neurotypical individual. At 1mM lithium, the data showed increased myo-inositol levels across cell lines; however, the results were not …

2025 Academic Conference Program

Holy Cross Undergraduate Academic Conference

No abstract provided.

Sex Differences In Exercise And Sleep Among University Faculty And Staff Members, Jorge O. Vazquez, David A. Tobar, Faith Yingling, K Todd Keylock

Topics in Exercise Science and Kinesiology

Topics in Exercise Science and Kinesiology Volume 6: Issue 1, Article 4, 2025. There has been minimal research examining the exercise and sleeping patterns of university faculty and staff members and what role these factors play in overall health. The information gathered in this study was used to analyze how faculty and staff can adapt their behaviors to improve health and well-being. To explore sex differences in exercise and sleep in faculty and staff at a university in the Midwest, the study performed secondary analyses on data collected from the 2022 American College Health Association’s National Faculty and Staff Health …

The Effects Of Palm Cooling On Repeat Sprint Ability Following A Fatigue Inducing Protocol In Collegiate Female Athletes, Ella Wrabley, Britta Lagerquist, Grace Smith, Rachel Jones, Madeline Mcneilly, Jeff Buxton, Hayden Gerhart, Phillip Prins

International Journal of Exercise Science

International Journal of Exercise Science 18(3): 415-426, 2025. Cooling glabrous skin sites, such as the palms, can mitigate core body temperature rise and delay fatigue during physical activity, potentially enhancing performance. However, research on palm cooling (PC) in female athletes remains limited, and existing devices are often costly or impractical. This study evaluated the effects of PC using a novel, cost-effective portable device on repeat sprint ability in female collegiate athletes after a fatiguing protocol. Twenty female athletes (age: 20.1±1.4 years; height: 166.7±6.9 cm; mass: 66.6±9.8 kg; BMI: 24.0±3.9 kg/m²; body fat: 24.9±4.6%) participated in a randomized crossover study. Sessions …

We Are Our Brains: Disembodied Brain Films In 1950s Cold War America, David P. Pierson

Faculty, Staff, and Alumni Books

Personified Body Parts in Cinema, Literature, and Visual Culture investigates the power of personifying body parts in cinema, television, visual culture, literature, erotica, folklore, and mystique.

Culturally, socially, and poetically exposing hidden aspects and subtleties of human existentialism, this book vigorously questions and problematizes numerous artistic, aesthetic, technological, naïve, and macabre manipulations of body parts for various purposes. A diverse team of authors explore how scribing human traits to limbs, eyes, brains, genitalia, hearts, and other inner organs is grotesque and aesthetic, repealing and appealing, intimidating and intimate, rude and enjoyable, material and spiritual, surprising and mundane. Personified organs are …

The Effects Of Stress On Injury And Sickness Rates Of Middle-Distance And Distance D3 Athletes, Hailey D. Smith Ms.

Student Scholar Showcase

A runner intentionally stresses their body to experience an adaptation, however, issues occur when the body does not have time to recover. Male athletes (n = 14) on the University of Lynchburg’s distance and middle-distance team participated in this study. For 6 weeks, heart rate variability (HRV4training app), resting heart rate, perceived stress, and cortisol levels were assessed as indicators of recovery and stress. It was anticipated that indicators of physical stress such as higher resting heart rates and higher cortisol levels, would correspond with greater perceived stress and higher occurrence of injury and sickness. Cortisol (n = 2, p …

How Childhood Maltreatment Shapes Brain Regions: Considerations For Speech-Language Pathology, Alexa G. Sees

Honors Thesis

Childhood maltreatment is a pervasive issue that affects millions of children worldwide, leading to alterations in key structures such as the limbic system, basal ganglia, corpus callosum, visual cortex, and language areas. These changes result in significant cognitive, emotional, and neurological consequences, such as learning deficits, emotional regulation issues, memory problems, reduced vocabulary size, speech errors, etc. This thesis explores the neurological effects of childhood maltreatment and their implications for speech-language pathology, highlighting how maltreatment-induced brain changes affect areas within the scope of speech-language pathology, such as social communication, language development, and behavior management. These results underscore the importance of …

How Aza Zoos And Aquariums Are Helping To Fill The Gap, Erika Bauer, Grace Fuller, Candice Dorsey

Animal Sentience

Oldfield & Bonano (2024) identify significant gaps in scientific knowledge about certain animal taxa, such as reptiles, amphibians, invertebrates, and fish. Despite some efforts, published literature remains limited, forcing decision-makers to rely more on experiential knowledge than scientific evidence. AZA-accredited zoos and aquariums are uniquely positioned to bridge these gaps and advance animal welfare science by fostering collaboration, building partnerships, and promoting multi-disciplinary approaches to welfare assessments.

Models And Mechanisms Of Chemotherapy-Induced Side Effects, Junwei Du

McKelvey School of Engineering Graduate Student Theses & Dissertations

Cancer is among the leading causes of death worldwide. Chemotherapy remains a cornerstone in the treatment of various cancers; however, it often leads to a range of debilitating side effects that compromise its efficacy and profoundly impact patients' quality of life and psychosocial well-being. These side effects can be broadly categorized into short-term effects, such as nausea, vomiting, fatigue, hair loss, and neutropenia, and long-term effects which can persist months or even years after treatment, including peripheral neuropathies, cognitive impairment, cardiotoxicity, nephrotoxicity and ototoxicity. Among the most common and dose-limiting side effects are chemotherapy-induced peripheral neuropathy (CIPN) and cardiotoxicity (CTX). …

Perfectionism, Anxiety, And Depression: A Comparison Of Student Mental Health At East Texas A&M University: Honors Vs Non-Honors, Connor Hall

Honors Theses

Honors students at East Texas A&M University (ETAMU) may have higher expectations to succeed due to greater course load and pressure versus students who are not in the honors program. These expectations can lead to stress that may cause perfectionism, anxiety, or depression (Rice, 2006; Wan, 2022; Van Praag, 2004). This study sought to determine if higher expectations and course load could lead to differences in mental health in honors versus non-honors students at East Texas A&M University. In order to determine these mental health characteristics, data was gathered using responses to a Qualtrics survey sent to 7527 ETAMU undergraduate …

The Implications Of The Scientific Developments Behind Oxidative Stress, Heat-Shock Proteins, And Antioxidants On Neurodegenerative Pathology, Nolan Wilbourn

Honors Theses

Homeostasis is essential for the health and development of all organisms, serving as a universal defense mechanism that ensures the stability of physiological processes faced with external and internal stimuli in the form of health challenges (Archana et al., 2017). Maintaining homeostasis is crucial for our health, as it helps keep the body's internal balance. However, this delicate equilibrium is challenged by various environmental factors, such as diet, exposure to chemicals, and fluctuations in temperature (Collier et al., 2017). These disruptions can lead to dysfunction in cellular processes, particularly affecting the production and regulation of proteins vital for biological functions. …

Case Study: Effect Of Stroboscopic Vision Training During A Softball Season, Doug Dendy, C Roger James, Toby Brooks, Micah Lierly, Nolan Riley, Larry Munger

Topics in Exercise Science and Kinesiology

Topics in Exercise Science and Kinesiology Volume 6: Issue 1, Article 3, 2025. This case study examined the effects of stroboscopic vision training during an entire varsity softball season for a 16-year-old female. Stroboscopic vision training uses specialized glasses with crystallized fluid that flickers, intermittently impeding vision, a technique that enhances visual performance. The stroboscopic glasses were worn two to three times a week during hitting and fielding skills. The central hypothesis was that the stroboscopic vision training would enhance softball vision performance. The central hypothesis was tested using these specific aims: 1) batting statistics for a year with no …

Psilocybin Impairs The Extinction Of Contextual Fear In Adult Female, But Not Male, Rats, Lillianna P. Puppel, Aleece K. Al-Olimat, Kylie M. King, Marisa J. Savini, Claire E. Miller, Colin R. Del Valle, Heather R. Sparkman, Brooke E. Bramlage, Phillip R. Zoladz

ONU Student Research Colloquium

Fear-related disorders are often treated with exposure therapy, a technique based on the concept of extinction. However, this type of therapy is ineffective for many individuals, so finding a pharmacological adjunct that augments the extinction of fear could lead to better treatment outcomes. In recent preclinical work, investigators have shown that psychedelics can accelerate the extinction of fear, potentially through their impact on neurotrophic signaling. We previously found that psilocybin exerted sex-dependent effects on the extinction of conditioned fear to an isolated cue (i.e., a tone). Specifically, psilocybin enhanced the extinction of cue fear in male rats but impaired it …

The Role Of Urbanization And Corticosterone In Auditory Sensory Processing In House Sparrows (Passer Domesticus), Brooke Fox, Ashley Lauraine, Hannah Peterson

24th Annual A. Paul and Carol C. Schaap Celebration of Undergraduate Research and Creative Activity (2025)

Urban habitat expansion will introduce new anthropogenic challenges for wildlife populations, including habitat fragmentation, novel predators, and pollution. These challenges may hinder animal communication and contribute to increased stress levels. This study will investigate the physiological consequences of stressors on the house sparrow (Passer domesticus). Specifically, we will examine how urbanization affects stress hormone (i.e., corticosterone, CORT) levels and its relationship to auditory processing. It is predicted that urbanization may impose novel stressors on animals, leading to differences in this hormone across urban and rural birds. We seek to understand if differences in CORT levels could impact animals' …

The Role Of Cholinergic Ventral Pallidum Cells In Effortful Motivation, Elizabeth A. Bien

Dartmouth College Ph.D Dissertations

Maladaptive reward-seeking behavior can be driven by one of several different components including excessive craving elicited by cues that predict rewards, failing to effortfully pursue rewards when it is beneficial to do so, and compulsively seeking rewards when it is no longer advantageous to do so. This thesis includes experiments focusing on these three different components of reward-seeking behavior to better understand how reward-seeking can become maladaptive. First, we wanted to examine the role that sex plays in the acquisition and compulsiveness of sign-tracking behavior in the Long Evans rat, a strain that is commonly used as the background for …

Local Nutrient Addition Drives Plant Diversity Losses But Not Biotic Homogenization In Global Grasslands, Qingqing Chen, Shane A. Blowes, W. Stanley Harpole, Emma Ladouceur, Elizabeth T. Borer, Andrew Macdougall, Erika Hersch-Green, Et Al.

Michigan Tech Publications

Nutrient enrichment typically causes local plant diversity declines. A common but untested expectation is that nutrient enrichment also reduces variation in nutrient conditions among localities and selects for a smaller pool of species, causing greater diversity declines at larger than local scales and thus biotic homogenization. Here we apply a framework that links changes in species richness across scales to changes in the numbers of spatially restricted and widespread species for a standardized nutrient addition experiment across 72 grasslands on six continents. Overall, we find proportionally similar species loss at local and larger scales, suggesting similar declines of spatially restricted …

Cognitive Correlates Of Borderline Personality Disorder Features In Youth With Bipolar Spectrum Disorders And Bipolar Offspring, Alessio Simonetti, Sherin Kurian, Evelina Bernardi, Antonio Restaino, Francesca Bardi, Claudia Calderoni, Gabriele Sani, Jair C Soares, Kirti Saxena

Faculty, Staff and Student Publications

Background: Bipolar disorder (BD) and borderline personality disorder (BPD) share common cognitive impairments. These deficits are also shared by bipolar offspring (BD-OFF). Nevertheless, little is known regarding the association between cognitive impairments and BPD features in youth with BD and BD-OFF. Objectives: This study aimed to investigate the association between BPD features and cognitive impairments in youth with BD and BD-OFF.

Methods: Thirty-nine participants (7-17 years) with BD, 18 BD-OFF, and 50 healthy controls (HCs) were recruited. BPD features were assessed using the Borderline Personality Features Scale for Children (BPFS-C). Deficits in executive functions and affective processing were assessed using …

Bryant University Research And Engagement Day Program

Bryant REDay (Research and Engagement Day)

No abstract provided.

Examining Physiological Responses To Misophonic Triggers, Christian O'Reilly, Xuan Yang, Sewon Oh, Doug Wedell, Svetlana Shinkareva

Faculty Publications

We collected and analyzed an array of biosignals (face electromyogram, skin electrodermal activity, peripheral temperature, and electrocardiogram) in 60 participants with and without misophonia, a condition characterized by decreased tolerance to innocuous sounds. Our goal was to objectively characterize the physiological response to misophonia triggering sounds. We found that misophonic responses can be objectively identified in some cases through atypical physiological reactions to triggering stimuli, though not all participants exhibited this response. Our analyses suggest a large interindividual variability in response to misophonic triggers and highlights the need for methodological adjustments in future experiments to increase the detectability of misophonic …

Identifying The Human Olfactory And Chemosignaling Neural Networks Using Event Related Fmri And Graph Theory, Saideh Ferdowsi, Tom Foulsham, Alireza Rahmani, Dimitri Ognibene, Luca Citi, Wen Li

Faculty, Staff and Student Publications

This study aims to characterize and compare the functional neural networks associated with different olfactory stimuli, including air, non-social odours, and human body odours. We introduce a novel processing pipeline based on event-related functional magnetic resonance imaging (fMRI) and graph theory for network identification. To ensure the stability and small worldness of the characterized networks, we conduct statistical validations, network modularity assessments, and robustness measurement against local attacks. The key hypothesis is that human body odours (so-called social odours) and non-social odours engage distinct neural networks, particularly in regions responsible for social processing. We found that the posterior medial orbitofrontal …