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Full-Text Articles in Entire DC Network
Impact Of Lighting Wavelength On Broiler Behavior, Health, And Performance, Angela Perretti
Impact Of Lighting Wavelength On Broiler Behavior, Health, And Performance, Angela Perretti
Graduate Theses and Dissertations
Lighting influences broiler production, health, and behavior. Due to their advanced visual system, avian species perceive a wide spectrum of light. The objective of this study was to investigate the effects of white (W, 350 to 780 nm) blue (B, 450 nm), and green (G, 560 nm) light on broiler production, processing performance, activity, fear, stress, blood cell profiles, tibiotarsi (tibia) morphology, and depth perception. Day-of-hatch by-product chicks from a Cobb 500 female line (N=600) were randomly assigned to 12 pens (N=4 treatment replicates). Body weight and feed consumption were recorded on day (D) 0, 14, 28, and 41, and …
Provider Attitudes And Perspectives On Rehabilitation For Pediatric Cancer Patients, Maria C Swartz, Eduardo Gonzalez Villarreal, Keri Schadler, Donna Kelly, Alakh P Rajan, Clark Andersen, Shiming Zhang, Stephanie J Wells, Amy Heaton, Karen M Moody
Provider Attitudes And Perspectives On Rehabilitation For Pediatric Cancer Patients, Maria C Swartz, Eduardo Gonzalez Villarreal, Keri Schadler, Donna Kelly, Alakh P Rajan, Clark Andersen, Shiming Zhang, Stephanie J Wells, Amy Heaton, Karen M Moody
Faculty, Staff and Student Publications
PurposeTwenty percent of childhood cancer survivors experience physical function impairments, and ∼75% develop a chronic health condition. Physical and occupational therapists (PT/OTs) can mitigate these late effects, yet few children receive cancer rehabilitation (CR). This research aimed to identify provider attitudes and perspectives towards CR services for children across inpatient and outpatient settings at a cancer center.MethodsThree cardiac rehabilitation instruments were adapted to evaluate knowledge, attitudes, and perceptions regarding CR delivery. Descriptive statistics were used to summarize participant survey results.ResultsTwenty administrators, 20 physicians/advanced practice providers (APPs), and 20 PT/OTs completed surveys. All disciplines strongly agreed on the value of CR …
Large-Scale Genome-Wide Analyses Of Stuttering, Hannah G Polikowsky, Alyssa C Scartozzi, Douglas M Shaw, Dillon G Pruett, Hung-Hsin Chen, Lauren E Petty, Alexander S Petty, Emily J Lowther, Shu-Hsien Cho, Yao Yu, Sahar Mozaffari, Christy L Avery, Kathleen Mullan Harris, Reyna L Gordon, Janet M Beilby, Kathryn Z Viljoen, Robin M Jones, Chad D Huff, Heather M Highland, Shelly Jo Kraft, Jennifer E Below
Large-Scale Genome-Wide Analyses Of Stuttering, Hannah G Polikowsky, Alyssa C Scartozzi, Douglas M Shaw, Dillon G Pruett, Hung-Hsin Chen, Lauren E Petty, Alexander S Petty, Emily J Lowther, Shu-Hsien Cho, Yao Yu, Sahar Mozaffari, Christy L Avery, Kathleen Mullan Harris, Reyna L Gordon, Janet M Beilby, Kathryn Z Viljoen, Robin M Jones, Chad D Huff, Heather M Highland, Shelly Jo Kraft, Jennifer E Below
Faculty, Staff and Student Publications
Developmental stuttering is a highly heritable, common speech condition characterized by prolongations, blocks and repetitions of speech. Although stuttering is highly heritable and enriched within families, the genetic architecture is largely understudied. We reasoned that there are both shared and distinct genetic variants impacting stuttering risk within sex and ancestry groups. To test this idea, we performed eight primary genome-wide association analyses of self-reported stuttering that were stratified by sex and ancestry, as well as secondary meta-analyses of more than one million individuals (99,776 cases and 1,023,243 controls), identifying 57 unique loci. We validated the genetic risk of self-reported stuttering …
A Convergent Mixed Methods Study Of The Social Studies Academy In South Carolina Middle Schools, Audie Cherry
A Convergent Mixed Methods Study Of The Social Studies Academy In South Carolina Middle Schools, Audie Cherry
All Dissertations
There is a global labor shortage in the agricultural industry and middle school is a critical time to get students serious about career decision making. The Studies of Occupations, Culture, and Innovations toward Agricultural Literacy (SOCIAL) Studies Academy is a high impact professional development program in South Carolina that provides experiences and for middle school social studies teachers (N = 12) to become more suited to teach their standards associated with the agricultural sciences with hopes of encouraging more students to pursue agricultural careers. This study was a mixed-methods convergent parallel design that examined 1) Academy Fellows (n = 4) …
Dermatoglyphic Fluctuating Asymmetry In Schizotypy, Marcus R. Thomas
Dermatoglyphic Fluctuating Asymmetry In Schizotypy, Marcus R. Thomas
All-Inclusive List of Electronic Theses and Dissertations
Schizotypy has been linked with many of the proposed endophenotypes of schizophrenia, but research is limited on the relationship between schizotypy and dermatoglyphic fluctuating asymmetry. The present study sought to examine relationships between schizotypy, dermatoglyphic fluctuating asymmetry, handedness, and season of birth. 146 undergraduate students were identified as schizotypes (n = 52) or controls (n = 94) based on the Multidimensional Schizotypy Scale and had their finger and palm prints collected along with completing additional measures of schizotypy and handedness. Schizotypes did not exhibit a greater degree of dermatoglyphic fluctuating asymmetry, negative schizotypy was associated with increased absolute finger ridge …
Optimization Of Mhealth Behavioral Interventions For Patients With Chronic Lymphocytic Leukemia: The Health4cll Study, Che Young Lee, Max J Gordon, Melissa M Markofski, Emily C Lavoy, Susan K Peterson, Liang Li, Sara Fares, Miranda Baum, Margaret Pace, Danielle Walsh, Alessandra Ferrajoli, Karen Basen-Engquist
Optimization Of Mhealth Behavioral Interventions For Patients With Chronic Lymphocytic Leukemia: The Health4cll Study, Che Young Lee, Max J Gordon, Melissa M Markofski, Emily C Lavoy, Susan K Peterson, Liang Li, Sara Fares, Miranda Baum, Margaret Pace, Danielle Walsh, Alessandra Ferrajoli, Karen Basen-Engquist
Faculty, Staff and Student Publications
Purpose: This pilot study of a diet and physical activity intervention (HEALTH4CLL) was conducted to reduce fatigue and improve physical function (PF) in patients with chronic lymphocytic leukemia (CLL).
Methods: The HEALTH4CLL study used a randomized factorial design based on the multiphase optimization strategy (MOST). Patients received diet, exercise, and body weight management instructional materials plus a Fitbit and were randomized to undergo one of 16 combinations of 4 evidence-based mHealth intervention strategies over 16 weeks. Patients' fatigue, PF, health-related quality of life, behavior changes, and program satisfaction and retention were assessed. Paired t-tests were used to examine changes in …
The Effects Of Off-Season Evidence-Based Training Block Periodization Program On The Performance Of Soccer Athletes In A Di School: An Exploratory Study, Ibrahim F. Almughathawi
The Effects Of Off-Season Evidence-Based Training Block Periodization Program On The Performance Of Soccer Athletes In A Di School: An Exploratory Study, Ibrahim F. Almughathawi
Electronic Theses and Dissertations
The investigators explored the effects of a two-year evidence-based block periodization strength training program on performance outcomes in NCAA Division I male soccer athletes. The investigators aimed to examine longitudinal changes in body composition, explosive strength, and match-play physical demands, as well as the associations between field-based performance assessment and GPS-derived metrics. Using a retrospective design, data were drawn from a research data repository for athletes who participated in a long-term sport science monitoring program under the same head coach and training conditions. Performance measures included vertical jump assessments (static and counter movement jumps under bodyweight and external load), isometric …
Sex Differences In The Risk Of Developing Alzheimer Disease, Cognitive Trajectories, And Relationships Between Cognition And Pathological Burden, Carling G. Robinson
Sex Differences In The Risk Of Developing Alzheimer Disease, Cognitive Trajectories, And Relationships Between Cognition And Pathological Burden, Carling G. Robinson
Arts & Sciences Graduate Student Theses and Dissertations
Prior work suggests females may develop Alzheimer disease (AD) dementia at a higher rate than males, and that this effect may interact with apolipoprotein (APOE) ε4 genotype. However, this work has often been limited by imprecise clinical diagnoses and a lack of AD biomarkers. In addition to the frequency of dementia, there are mixed reports on whether sex impacts rates of cognitive decline. Further, females consistently exhibit greater accumulation of AD pathological biomarkers, particularly tau, than males. It has been theorized that females initially demonstrate resilience to AD pathology, maintaining cognitive functioning longer than males, but experiencing a steeper cognitive …
Towards Improving Computational Modeling Of The Lumbar Spine - Impact Of Material Properties And Laminotomy On Spinal Biomechanics, Isaac K. Kumi
Towards Improving Computational Modeling Of The Lumbar Spine - Impact Of Material Properties And Laminotomy On Spinal Biomechanics, Isaac K. Kumi
Mechanical & Aerospace Engineering Theses & Dissertations
Spinal ligaments play a crucial role in maintaining the mechanical stability of the lumbar spine. These dense, collagenous tissues not only resist excessive motion but also distribute loads between spinal components to protect neural structures. Traditionally, the mechanical response of ligaments has been modeled using linear elastic assumptions, which treat the tissue as having a constant stiffness regardless of loading history. While this simplifies analysis, it fails to capture the time-dependent behaviors, such as creep, stress relaxation, and hysteresis, that are characteristic of biological tissues.
Viscoelastic modeling may provide a more physiologically accurate representation by incorporating both elastic and viscous …
Saliva & Circadian Rhythm In Medical Profiling For Early Disease Prevention, Joseph Lewis
Saliva & Circadian Rhythm In Medical Profiling For Early Disease Prevention, Joseph Lewis
Graduate Student Dissertations, Theses, Capstones, and Portfolios
Circadian rhythms affect almost every biological process from hormone secretion, gene expression, immune regulation, and metabolism. Studies show that disruption to these internal rhythms through irregular sleep, artificial sleep, and irregular sleep can significantly increase risk for chronic disease such as diabetes, cardiovascular disorders, neurodegeneration, and cancer. Saliva presents a viable alternative for capturing biomarkers found through blood or cerebrospinal fluid, offering substantial utility for diagnostic and chronobiological profiling. Saliva contains hormones such as cortisol and melatonin while containing inflammatory markers that fluctuate rhythmically throughout the day. Due to its ease of collection, saliva is well suited for longitudinal monitoring, …
Eccentric Hamstring Strength And Acl Injury Risk In Ncaa Division I Female Field Hockey Athletes, Killian Patrick Ferrell
Eccentric Hamstring Strength And Acl Injury Risk In Ncaa Division I Female Field Hockey Athletes, Killian Patrick Ferrell
Exercise Science Theses & Dissertations
Anterior cruciate ligament (ACL) injuries remain a pervasive issue in female collegiate athletics, particularly in sports demanding frequent decelerations, cuts, and high-speed movements such as field hockey. Despite the high injury burden, limited research has investigated biomechanical and workload-based risk factors specific to NCAA Division I female field hockey athletes. This study aimed to evaluate the relationship between changes in eccentric hamstring strength and movement load metrics with changes in a composite ACL Risk Index. The sample included nine NCAA Division I female field hockey players who completed a 13-week offseason strength and conditioning program. Eccentric hamstring strength was measured …
The Inside Scoop: Elucidating The Three-Way Relationship Between Schistosoma Mansoni, The Gut, And Vaccines, Mariam A. Mhanna
The Inside Scoop: Elucidating The Three-Way Relationship Between Schistosoma Mansoni, The Gut, And Vaccines, Mariam A. Mhanna
Biomedical Sciences Theses & Dissertations
Schistosomiasis is a neglected tropical disease that affects over 250 million people worldwide. This blood fluke infection burdens communities and areas with limited to no access to clean fresh water. When a host is exposed to cercariae, the infectious agent, in a body of water, it matures in the host’s circulation into adult female and male worms. Copulated adult worms migrate to the mesentery, in the case of Schistosoma mansoni, and produce eggs that can cross the intestinal barrier and get excreted in the feces to continue the lifecycle. The effects of S. mansoni infection on the host …
Evaluating Maternal Polar Bear Denning Habitat Along The Arctic Coastal Plain And Assessing The Potential For Noise Disturbance In Polar Bear Dens, Ethan Ducharme
All Graduate Theses and Dissertations, Fall 2023 to Present
Polar bears (Ursus Maritimus) in northern Alaska are increasingly choosing land instead of sea ice to build their maternity dens. As sea ice continues to decline due to climate change, this shift makes it more important than ever to identify and protect the areas where polar bears dig dens to give birth and raise their cubs. In the first part of my research, I used new satellite-based elevation data to map potential polar bear denning habitat across a large section of Alaska’s Arctic Coastal Plain. This technology allowed me to identify the types of sloped terrain where drifting …
What’S The Beef With Agriculture? Evaluating The Effectiveness Of An Agricultural Literacy Intervention On Students’ Attitudes And Knowledge Toward Sustainability And Animal Agriculture, Jenny E. Bennett
All Graduate Theses and Dissertations, Fall 2023 to Present
Agricultural literacy is essential for helping individuals understand how food systems impact their daily lives and society. While most research has focused on students’ knowledge, this study addresses the underexplored role of attitudes—critical predictors of behavior—as outcomes of educational interventions. This research analyzed survey data collected before and after an agricultural literacy intervention delivered to high school students in school-based agricultural education (SBAE) programs. The curriculum focused on sustainability in animal agriculture.
Findings from paired samples t-tests showed statistically significant improvements in students' attitudes (from moderately neutral to more positive) and knowledge scores. Further analyses revealed that demographic factors such …
Assessment Of Covid-19 Risks Related To Behaviour And Body Resistance In The Remote Area: Case Study In Jeneponto, Basri Basri, Andi Tilka Muftiah Ridjal, Lukman Setiawan, Renaldi M
Assessment Of Covid-19 Risks Related To Behaviour And Body Resistance In The Remote Area: Case Study In Jeneponto, Basri Basri, Andi Tilka Muftiah Ridjal, Lukman Setiawan, Renaldi M
Journal of Environmental Science and Sustainable Development
COVID-19 has posed significant global health threats, with responses varying across populations due to differences in risk perception, behaviour, and biological vulnerability. In Indonesia, most research has focused on urban settings, with limited attention paid to rural or remote communities. This study assesses COVID-19- risks related—specifically behavioural and immunity-related-factors—in the remote area of both Bontoramba Subdistrict, Jeneponto Regency. A cross-sectional study was conducted using cluster random sampling across eight villages, with 183 participants selected from a total of 12,242 households. Data were collected between November to December 2020 using a validated structured questionnaire, administered both online and face-to-face interviews. The …
Effective And Eco-Friendly Strategies To Control Birds In Industrial Estate, Jasti Rahayu, Upik K. Hadi, Susi Soviana
Effective And Eco-Friendly Strategies To Control Birds In Industrial Estate, Jasti Rahayu, Upik K. Hadi, Susi Soviana
Journal of Environmental Science and Sustainable Development
Bird infestations in industrial areas can cause infrastructure damage, contamination, and health risks. Despite these impacts, they are rarely addressed in environmental management strategies. At the Kaltim Industrial Estate (KIE) in Bontang, East Kalimantan, synanthropic bird species that thrive in human-altered environments have become persistent nuisances, particularly because of structural opportunities for roosting and altered ecological conditions. To address this issue, this study applied Integrated Pest Bird Management (IPBM), a non-lethal and environmentally friendly approach that combines species identification, behavior analysis, and targeted deterrents. IPBM was selected for its adaptability to industrial settings and its alignment with sustainable development goals. …
Understanding Offline Pro-Environmental Identity: Factors And Implications, Tusyanah Tusyanah, Rahayu Puji Haryanti, Wijang Sakitri, Ismiyati Ismiyati, Nur Chayati
Understanding Offline Pro-Environmental Identity: Factors And Implications, Tusyanah Tusyanah, Rahayu Puji Haryanti, Wijang Sakitri, Ismiyati Ismiyati, Nur Chayati
Journal of Environmental Science and Sustainable Development
Given global environmental challenges, developing sustainable behavior among pre-service teachers is crucial, as they will be responsible to educate future generations who must contribute to solving environmental problems. Offline pro-environmental identity refers as the individual's environmental commitment in real-life setting. Previous studies have primarily focused on online identity and behavioral intentions, while real-life behavioral context have not been fully examined. The goal of this study was to investigate the effects of the online pro-environmental identity, the perceived behavioral control, and the moral identity on the behavioral intention and the offline pro-environmental behavior. The study employed a quantitative research design and …
Sustainable Water Management In Universities: Perceptions, Behaviours, And Challenges, Hastin Setiani, Dwita Sutjiningsih, Riri Fitri Sari
Sustainable Water Management In Universities: Perceptions, Behaviours, And Challenges, Hastin Setiani, Dwita Sutjiningsih, Riri Fitri Sari
Journal of Environmental Science and Sustainable Development
Universities are increasingly adopting the “living laboratory” model to implement and evaluate sustainability innovations. These settings enable students, staff, and stakeholders to co-create and test real-world solutions, including those related to water use. Universitas Indonesia promotes sustainability through an integrated approach encompassing policy development, academics programs, and infrastructures. Prior studies using the Theory of Planned Behavior (TPB) have demonstrated that attitudes and perceived norms significantly influence sustainable behavior. However, limited research has examined how these dynamics operate within Indonesian universities or how university-based initiatives may contribute to broader urban water management. This study addresses that gap by examining perceptions, behaviors, …
Assessing The Transformation Of Livelihoods In Illegal Gold Mining Communities, Nurmansyah Ardikoesoema, Mahawan Karuniasa
Assessing The Transformation Of Livelihoods In Illegal Gold Mining Communities, Nurmansyah Ardikoesoema, Mahawan Karuniasa
Journal of Environmental Science and Sustainable Development
Illegal Artisanal Small-Scale Gold Mining (PETI) in Poboya, Palu City, exemplifies Indonesia’s nexus of socio-environmental vulnerability and institutional marginalization. Although environmental degradation, health impacts, and regulatory challenges associated with PETI have been extensively documented, limited research has systematically examined how the interplay of capital assets and internal motivation drives livelihood transformation pathways within PETI communities. To address this gap, this study uniquely integrates the Sustainable Livelihood Framework with spatial analysis to assess the combined influence of environmental, social, and economic capitals on PETI livelihood transitions. Using a mixed-methods approach, data were collected through quantitative survey and qualitative in-depth interviews with …
Bibliometric And Content Analysis: Application Of The Theory Of Planned Behavior In Environmental Issues, Nofi R.A.R Samputra, Kurniawaty Iskandar, Tri Edhi Budhi Soesilo, Dwi Nowo Martono
Bibliometric And Content Analysis: Application Of The Theory Of Planned Behavior In Environmental Issues, Nofi R.A.R Samputra, Kurniawaty Iskandar, Tri Edhi Budhi Soesilo, Dwi Nowo Martono
Journal of Environmental Science and Sustainable Development
Theory of Planned Behavior (TPB) has been widely applied in environmental science as it closely linked to human behavior. This study aims to analyze research trends, identify potential future research, and propose the development of an integrative TPB model to address gaps in previous research. A total of 120 articles were selected from the Scopus database using rigorous screening criteria, including title-based selection, English-language articles, and a manual abstract review, covering publications up to April 4, 2025. Bibliometrix, VOSviewer, and MindMup were used to support keyword visualization and content interpretation. The results show that China and the United States lead …
How Beliefs Shape What We Consider When Choosing What To Eat, Christopher Gustafson
How Beliefs Shape What We Consider When Choosing What To Eat, Christopher Gustafson
Cornhusker Economics
What determines which foods we consider? One factor, certainly, is what we like to eat, and if liking what we eat were the sole relevant outcome of food consumption, there would be little to say about incomplete consideration. However, diet quality has important, well-documented effects on health outcomes (as well as other important considerations, such as differential environmental impact). Close to 75 percent of American adults are overweight or obese, which increases the likelihood that the individual will experience one or more serious non-communicable diseases. A food’s healthiness is an important consideration for many people when making food choices, but, …
Cultivating The Wild: Strategies For Entrepreneurs Navigating Niche And Specialty Food Markets, Trey Malone, Courtney F. Cooper
Cultivating The Wild: Strategies For Entrepreneurs Navigating Niche And Specialty Food Markets, Trey Malone, Courtney F. Cooper
Agricultural Economics and Agribusiness Faculty Publications and Presentations
Introduction Consumer demand for authenticity and sustainability in food systems is growing, creating both opportunities and challenges for entrepreneurs in niche and specialty markets. While wild-foraged and hunted foods are often perceived as more "natural" and sustainable, attempts to scale these products through farming may compromise their perceived authenticity.Methods To explore these dynamics, we conducted discrete choice experiments with a nationally representative sample of 1,039 U.S. consumers. Participants evaluated their willingness to pay (WTP) for salmon, venison, and morel mushrooms, presented in both wild-foraged/hunted and farm-raised forms.Results Consumers exhibited strong preferences for wild versions of all three products, with average …
Health Patterns Of Dementia Caregivers With Chronic Pain: Latent Profile Analysis Of The Promis-29 Measure, Shelbie G. Turner, Dakota D. Witzel, Shana Garza, Karl Pillemer, M Carrington Reid
Health Patterns Of Dementia Caregivers With Chronic Pain: Latent Profile Analysis Of The Promis-29 Measure, Shelbie G. Turner, Dakota D. Witzel, Shana Garza, Karl Pillemer, M Carrington Reid
Human Genetics Publications
We identified patterns of health and functioning in a national sample of dementia family caregivers experiencing chronic pain (N = 273). Utilizing latent profile analysis of the 29-item Patient-Reported Outcomes Measurement Information System (PROMIS-29), we identified three discrete groups: an average group (48%), a low health challenges group (30%), and a high health challenges group (22%). Women were more likely to be in the high (vs. low) health challenges group. There are discrete health patterns of caregivers with chronic pain, with over 20% reporting comorbid poor health and functioning that may negatively affect caregiving quality. Screening caregivers for high …
Resilience Mediates The Association Between Discrimination And Psychological Distress Among Rural, Black Women In South Carolina: A Structural Equation Model, Camryn Garrett, Abhisheak Aggrawal, Huiyi Xia, Cheuk Chi Tam, Bankole Olatosi Ph.D., Sarah Wilcox Phd, Xiaoming Li Ph.D., Shan Qiao Ph.D.
Resilience Mediates The Association Between Discrimination And Psychological Distress Among Rural, Black Women In South Carolina: A Structural Equation Model, Camryn Garrett, Abhisheak Aggrawal, Huiyi Xia, Cheuk Chi Tam, Bankole Olatosi Ph.D., Sarah Wilcox Phd, Xiaoming Li Ph.D., Shan Qiao Ph.D.
Faculty Publications
Introduction
The marginalization of intersecting racial, gender, and rural identities compounds the structural vulnerabilities (e.g., discrimination, stigma, health disparities) experienced by Black women in South Carolina’s rural areas. Discriminatory experiences can deteriorate mental health; however, resilience can potentially reduce the ill effects of discrimination by decreasing associated psychological distress. This study examines the mediating role of resilience in the association between discrimination and psychological distress among rural, Black women in South Carolina in the post-pandemic era.
Methods
Black women (n = 300, mean age = 48.6) living in rural South Carolina were recruited from January to February 2024 using …
Cultural Worldview And Rural Consumer Preferences For Genetically Modified Foods, Nathan P. Kemper
Cultural Worldview And Rural Consumer Preferences For Genetically Modified Foods, Nathan P. Kemper
Agricultural Economics and Agribusiness Faculty Publications and Presentations
The consumer acceptance of genetically modified (GM) foods varies widely based on personal values and social context. This study investigates how cultural worldviews—measured through the Individualism–Communitarianism and Hierarchical–Egalitarianism dimensions—affect willingness to pay (WTP) for food labeling attributes related to GM content. We surveyed 932 U.S. primary grocery shoppers and conducted a discrete choice experiment (DCE) with poultry product options. Using a Mixed Logit model and supplemental cognitive data from Query Theory, we find that rural individualists are more accepting of GM-labeled products. At the same time, urban communitarians show a stronger preference for non-GM labels. These results offer insight into …
Autism Spectrum Disorder: A Review Of Genomic Risk Factors, Diagnostic And Pharmacotherapeutic Strategies, Zohor Azher
Autism Spectrum Disorder: A Review Of Genomic Risk Factors, Diagnostic And Pharmacotherapeutic Strategies, Zohor Azher
Saudi Toxicology Journal
Autism Spectrum Disorder (ASD) is a multifactorial neurodevelopmental condition characterized by impairments in social communication and delayed language development, repetitive behaviors, and sensory processing abnormalities. The genetic background of ASD remains incompletely understood due to significant genetic heterogeneity and complexity. This review aims to present current insights into the genetic landscape of ASD, focusing on both common and rare genomic variations. We describe candidate genes associated with ASD, as they are involved in synaptic function and neuronal signaling, making these findings potential therapeutic targets. This review emphasizes the importance of integrating comprehensive clinical assessments with advanced genetic investigations to enhance …
Adaptive Bayesian Clinical Trials: The Past, Present, And Future Of Clinical Research, Donald A Berry
Adaptive Bayesian Clinical Trials: The Past, Present, And Future Of Clinical Research, Donald A Berry
Faculty, Staff and Student Publications
Background/Objectives: Decision-analytic Bayesian approaches are ideally suited for designing clinical trials. They have been used increasingly over the last 30 years in developing medical devices and drugs. A prototype trial is a bandit problem in which treating participants is as important as treating patients in clinical practice after the trial.
Methods: This article chronicles the use of the Bayesian approach in clinical trials motivated by bandit problems. It provides a comprehensive historical and practical review of Bayesian adaptive trials, with a focus on bandit-inspired designs.
Results: The 20th century saw advances in Bayesian methodology involving computer simulation. In the …
Perception Of Quality Of Life, Brain Regions, And Cognitive Performance In Hispanic Adults: A Canonical Correlation Approach, Juan C. Lopez-Alvarenga, Jesus D. Melgarejo, Jesus Rivera-Sanchez, Lorena Velazquez-Alvarez, Rosa V. Pirela, John Blangero, Jose E. Cavazos, Michael C. Mahaney, Joseph D. Terwilliger, Gladys E. Maestre
Perception Of Quality Of Life, Brain Regions, And Cognitive Performance In Hispanic Adults: A Canonical Correlation Approach, Juan C. Lopez-Alvarenga, Jesus D. Melgarejo, Jesus Rivera-Sanchez, Lorena Velazquez-Alvarez, Rosa V. Pirela, John Blangero, Jose E. Cavazos, Michael C. Mahaney, Joseph D. Terwilliger, Gladys E. Maestre
School of Medicine Publications
The quality of life (QoL) perception has been studied in neurological diseases; however, there is limited information linking brain morphological characteristics, QoL, and cognition. Human behavior and perception are associated with specific brain areas that interact through diffuse electrochemical networking. We used magnetic resonance imaging (MRI) to analyze the brain region volume (BRV) correlation with the scores of Rand’s 36-item Short Form Survey (SF-36) and cognitive domains (memory and dementia status). We analyzed data from 420 adult participants in the Maracaibo Aging Study (MAS). Principal component analysis with oblimin axis rotation was used to gather redundant information from brain parcels …
The Relationship Between Hand Grip Strength And Cognitive Function In Middle-Aged And Elderly People In China: A Cross-Sectional Analysis Based On Charls Data, Haiwei Li, Jing Zhang, Peipei Cheng, Liwei Guo, Xuemei Sui M.D., M.P.H., Ph.D.
The Relationship Between Hand Grip Strength And Cognitive Function In Middle-Aged And Elderly People In China: A Cross-Sectional Analysis Based On Charls Data, Haiwei Li, Jing Zhang, Peipei Cheng, Liwei Guo, Xuemei Sui M.D., M.P.H., Ph.D.
Faculty Publications
This study explores the relationship between hand grip strength (HGS) and cognitive function in China’s middle-aged and elderly population. We employed a cross-sectional design using data from 4535 participants aged ≥ 45 years from the 2015 China Health and Retirement Longitudinal Study national dataset. The relationships between HGS and various dimensions of cognitive function, as well as the association between HGS and cognitive impairment, were investigated using ordinary least squares regression models and logistic regression models. Dose–response relationships between HGS and cognitive impairment were modeled using restricted cubic spline curves. Subgroup and sensitivity analyses were performed to assess the robustness …
Adhd In Youth With Major Depressive Disorder In The Texas Youth Depression And Suicide Research Network (Tx-Ydsrn): Clinical Correlates And Moderators, Blake M Upshaw, Samuel D Spencer, Caitlin M Pinciotti, Vadym Zhyrov, Abu Minhajuddin, Ace A Castillo, Allyssa Abacan, Holli Slater, Rachel A Walker, Joseph C Blader, Sarah L Martin, Jeffrey D Shahidullah, Jair C Soares, Robert Andrew Harper, Madelyn Guerra, Lynnel C Goodman, Wayne K Goodman, Sarah M Wakefield, Madhukar H Trivedi, Eric A Storch
Adhd In Youth With Major Depressive Disorder In The Texas Youth Depression And Suicide Research Network (Tx-Ydsrn): Clinical Correlates And Moderators, Blake M Upshaw, Samuel D Spencer, Caitlin M Pinciotti, Vadym Zhyrov, Abu Minhajuddin, Ace A Castillo, Allyssa Abacan, Holli Slater, Rachel A Walker, Joseph C Blader, Sarah L Martin, Jeffrey D Shahidullah, Jair C Soares, Robert Andrew Harper, Madelyn Guerra, Lynnel C Goodman, Wayne K Goodman, Sarah M Wakefield, Madhukar H Trivedi, Eric A Storch
Faculty, Staff and Student Publications
Objective: Depression is a major public health concern with a 19% lifetime prevalence in youth, often precipitating other concerns, including suicidal behavior, poor school performance, and worsened peer relationships. ADHD is also common among youth and frequently presents alongside major depressive disorder (MDD), with this comorbidity associated with increased impairment. More research is needed to elucidate the clinical characteristics of this comorbidity (MDD + ADHD), especially as it relates to youth with MDD and no ADHD (MDD - ADHD). The present study examined the clinical correlates of MDD + ADHD in youth and the presence of an ADHD diagnosis as …