Digital Commons Network^™

Detection And Enrichment Characteristics Analysis Of Common Heavy Metal Content In Different Organs Of Hunan Lotus Seed, Dai Hui, Zhao Wenyu, Wang Jianhui, He Xiangyi, Long Xiao

Food and Machinery

Objective: The objective of this study is to investigate the heavy metal content in sediment and various organs of Hunan lotus seed in a planting area, as well as to explore the characteristics of heavy metal accumulation and transfer in Hunan lotus seed. Methods: A typical planting area in Hunan Province was selected for this research. The contents of Cd, Cr, Pb, Ni, Cu, Zn and Mn were measured using an inductively coupled plasma emission spectrometer. The bioconcentration factor （BCF） and transfer factor （TF） were used to evaluate the heavy metal accumulation and transfer ability of Hunan lotus seed. Results: …

Study On The Performance Of Heat Pump Assisted Random Filler Surface Evaporation Device For Concentrated Thermosensitive Feed Liquid, Ma Yinglu, Chen Dong, Hu Shengwei, Wang Shuo, Zhang Huijuan, Xie Jihong

Food and Machinery

Objective： A surface evaporation concentration device were designed to concentrate thermosensitive feed liquid at low temperature under normal pressure with low energy consumption. Methods： Based on an introduction to the working principle of the device, the basic equations of the device were given. The changes of volumetric evaporation flux and energy saving ratio with flow rate of the feed liquid, feed liquid temperature, sweeping gas flow rate, sweeping gas temperature were calculated and analyzed. Designed an experimental platform and obtained a set of optimal performance parameters through experiments. Results： The results showed that when the flow rate of the feed …

Effect Of Chlorine Dioxide Fumigation Treatment On Quality Of Broccoli, Li Yuqing, Lu Lixin, Wang Qing

Food and Machinery

Objective： This study aimed to solve the problems of yellowing, discoloration and quality preservation of broccoli after harvesting. Methods： Broccoli was fumigated with chlorine dioxide gas at different mass concentrations (0,0.2, 0.5, 1.0, 1.5, 2.0 mg/L) at 23 ℃, and the sensory, color, yelination grade, physiological and biochemical indexes and related browning enzyme activities of broccoli were determined after 0,2,4,6,8 days of storage. Results： Compared with the control group, different mass concentrations of ClO₂ could inhibit the mass loss rate, yellowing browning and spoilage of flower buds of broccoli. ClO₂ at 0.5 and 1.0 mg/L had a more …

A Preliminary Study On The Effect Mechanism Of A Rice Immune Peptide In Mice, Wen Shiyu, Zhang Zhimeng, Wu Hao, Xie Yufei, Huang Qingming, Liao Juan, Wen Li

Food and Machinery

Objective: This study aimed to demonstrate the potential immunomodulatory activity in mice of rice immunopeptide GBP1 （NSVFRALPVDVVANAYR） screened previously. Methods: Animal experiments were conducted to investigate the immunomodulatory mechanism of GBP1 peptide. RNA-Seq was used to sequence the transcriptome of mouse spleen tissues before and after GBP1 peptide treatment, and the molecular mechanism of GBP1 peptide immunomodulatory effect was explained. Results: In the GBP1 peptide treatment group, the number of spleen cells tended to be normal, the liver organ coefficient decreased significantly, and the serum IgG content was stable.GBP1 peptide can affect the expression of cytokines, mediate signal transduction pathways, …

The Antitumor Activity Of Brassica Rapa L. Acid Polysaccharides In Vivo, Kadeer Gulimila, Maitiruze Amannisa, Li Mingzhu, Kang Jinsen, Taoerdahong Hailiqian

Food and Machinery

Objective: To explore the effects of Brassica rapa L. acid polysaccharide 1 (BRAP-1) on H226 cell tumor-bearing mice. Methods: 60 mice were divided into the model group (0.1 mL/10 g), positive cisplatin [3 mg/(kg·2 d)], BRAP-1 low dose [50 mg/(kg·d)], BRAP-1 medium dose [100 mg/(kg·d)] and BRAP-1 high dose [200 mg/(kg·d)]. During the experiment, the tumor growth of mice was observed, and the tumor inhibition rate and organ index were calculated; The levels of interleukin-18 (IL-18), interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α) in serum were detected by enzyme-linked immunosorbent assay. The gene expressions …

Analysis Of Flavor Characteristics Of Herbal Cultivated Tremella Fuciformis Based On Component Difference Analysis And Intelligent Sensory, Chen Wanchao, Wu Di, Xiao Minsheng, Yao Shuxian, Yang Yan, Liu Yanfang

Food and Machinery

Objective: Clarify the flavor characteristics of Tremella fuciformis cultivated on herbaceous substrate. Methods: In the study T. fuciformis cultivated on herbaceous substrate was used as the research object, while samples of yellow tremella and white tremella cultivated on conventional substrate were used as controls. The differences in flavor composition between them were analyzed using high-performance liquid chromatography and Headspace Solid Phase Microextraction Ggas Chromatography Mass Spectrometry (HS-SPME-GC-MS). And combined with intelligent sensory technology, its flavor characteristics were analyzed. Results: According to multi-dimensional evaluations such as fresh and sweet amino acid and flavor nucleotides content, taste activity value and equal freshness …

Effects Of Grape Seed Proanthocyanidins On Hepg2 Cell Genes And Related Functions Based On Transcriptome Sequencing, Zheng Wancai, Dang Bin, Zhang Ji, Luo Qiaoyu, Feng Zuoshan

Food and Machinery

Objective： Based on transcriptome sequencing analysis, the effect of grape seed procyanidins on HepG2 cell genes and related functions was identified. The key genes and metabolic pathways involved in the treatment of HepG2 cells with procyanidins were confirmed. Methods: Through transcriptome sequencing, screening differential genes, gene functional annotation and enrichment analysis of the KEGG pathway, transcriptome studies were conducted on grape proanthocyanidin-treated cells. Results: After treating HepG2 cells with grape anthocyanins, the main biological processes enriched are cellular processes, metabolic processes, biological regulatory processes, immune system processes, reproductive regulation, and growth regulation. Research has found that 12 key differentially expressed …

Optimization Of Anthocyanin Copigmentation Formula Of Purple Corn And Its Effect On The Quality Of Purple Corn, Pang Wenqian, Yu Rui, Li Dajing, Liu Chunju, Bai Bing

Food and Machinery

Objective: This study aimed to explore the copigmentation formula of purple corn anthocyanins. Methods: In this study, fructose, tannic acid, and pectin were used as co-pigmentation. The response surface method was used to optimize the co-pigmentation formula of purple corn anthocyanins, and the untreated purple corn was used as a control test. The anthocyanin components, color, texture, taste and antioxidant activity (DPPH free radical scavenging ability, ABTS free radical scavenging ability, and FRAP iron ion reducing ability) of purple corn after different treatments were determined. Results: 19% fructose, 0.07% tannic acid, and 1.9% pectin had the best copigmentation effect. Compared …

Effects Of Drying Methods On The Quality And Volatile Flavor Compounds Of Oil Tea Powder, Li Guanli, Wu Qiuyue, Chen Xixia, Wu Shujie, Duan Qiuxia, Li Xiaochun, Luo Yanghe

Food and Machinery

Objective: This study aimed to explore suitable drying methods for oil tea powder, making it easier for oil tea consumption and storage. Methods: Spray drying, vacuum freeze drying and vacuum drying were used to dry oil tea soup, and the quality (moisture content, sensory evaluation and color) and volatile substances of dried oil tea powder were evaluated. Results: The sensory score of vacuum freeze-drying oil tea powder was the highest (93), the water content was the lowest (3.78%), and the color was better（ΔE value 49.74). 104 volatile substances were identified from three drying methods of oil tea powder using …

Research Progress On The Mechanism Of Food-Derived Antihypertensive Peptides, Wang Baobei, Zhang Hui, Liu Yusong, Chen Hongbin, Guo Fengxian, Zheng Zongping

Food and Machinery

In this review, several mechanisms of antihypertensive peptides derived from food and its by-products were summarized. Mechanisms based on the RAAS system such as ACE/Ang Ⅱ/AT1R signaling pathways and ACE2/Ang (1-7)/MasR signaling pathways were included. Mechanisms targeting at KNOS system including PI3K/Akt/eNOS signaling pathway, PPAR-γ/caspase3/MAPK/eNOS signaling pathway and L-type Ca²⁺ channel were also discussed. In addition, the pathways of reducing blood pressure by inhibiting endothelin-converting enzyme (ECE) activity discovered in recent years were also introduced.

Molecular Insights Of Paraoxonase 2 In Advanced Glycation End Product Induced Endothelial Dysfunction, Ramya R

Theses and Dissertations

Diabetes mellitus (DM) is a metabolic disorder associated with various vascular complications and affects the function of the endothelial cells. Elevated blood glucose levels accelerate the formation of advanced glycation end products (AGEs) by Amadori rearrangement and bind to their Receptor for the advanced glycation end product (RAGE) and evoke release of key pro-inflammatory cytokine proteins leading to endothelial dysfunction. Paraoxonase 2 (PON2) is an endogenous intracellular enzyme, localised in mitochondria, endoplasmic reticulum (ER), and nuclear membrane with numerous properties, like anti-inflammatory, anti-apoptotic and anti-oxidant.

Our present study aims to ascertain the effect of AGEs on PON2 activity and expression, …

What Is The Additive Value Of Nutritional Deficiency To Va-Fi In The Risk Assessment For Heart Failure Patients?, Molly J Horstman, Christopher I Amos, Ariela Orkaby, Javad Razjouyan

Faculty, Staff and Student Publications

OBJECTIVES: to assess the impact of adding the Prognostic Nutritional Index (PNI) to the U.S. Veterans Health Administration frailty index (VA-FI) for the prediction of time-to-death and other clinical outcomes in Veterans hospitalized with Heart Failure.

METHODS: A retrospective cohort study of veterans hospitalized for heart failure (HF) from October 2015 to October 2018. Veterans ≥50 years with albumin and lymphocyte counts, needed to calculate the PNI, in the year prior to hospitalization were included. We defined malnutrition as PNI ≤43.6, based on the Youden index. VA-FI was calculated from the year prior to the hospitalization and identified three groups: …

Microbiological Quality Of Irrigation Water And Leafy Vegetables In Dar Es Salaam, Tanzania, Bubelwa L. Kamara, Godwill D. Mrema, Thomas J. Lyimo

Tanzania Journal of Science

The quality of water used for the irrigation of leafy vegetables in urban settings is in doubt due to contamination associated with poor hygiene and water pollution. This study examined the microbiological quality of irrigation water and leafy vegetables at Chang’ombe in Dar es Salaam, Tanzania as well as the perceptions and level of awareness of nearby consumers. Water and leafy vegetable samples were analysed for faecal coliform (FC) using standard techniques. Perception and awareness of consumers were collected using a questionnaire survey. The results showed an average FC count of 406.1 ± 16.40 MPN/100 ml for the irrigation water. …

Effects Of Silymarin On S. Aureus Atcc25923 Biofilm And Its Virulence Factors, Wang Jiakang, Tang Haoguo, Chen Jing, Si Qihe, Shen Ruxiao

Food and Machinery

Objective: In this study, the effects of silymarin on the biofilm S. aureus ATCC25923 and its virulence factors were investigated. Methods: The inhibition and clearance of silymarin on S. aureus ATCC25923 biofilm formation were detected by crystal violet staining, the effects of silymarin on its biofilm metabolism were investigated by MTT staining, and the effects of silymarin on its coagulase expression and hemolytic activity were investigated by freeze-dried plasma and aseptic defibrinated sheep blood. In parallel, the effects of different concentrations of silymarin on its biofilm and Fourier transform were observed under an optical microscope. Results: The results showed that …

Structural Characteristics And Hypoglycemic Activity Of Polysaccharides From Different Parts Of Wampee, He Junye, Liu Cheng, Yu Chongyang, Sun Pengpeng, Ren Yuanyuan

Food and Machinery

Objective: This study aimed to develop antioxidant products and anti-diabetes drugs of wampee. The study aimed to research the structural characteristics, anti-oxidation and hypoglycemic properties in vitro of polysaccharides from different parts of wampee. Methods: The structural properties, in vitro antioxidant and hypoglycemic activities of polysaccharides from the fruit, peel and seeds of wampee (CWP-F, CWP-P, and CWP-S) were analyzed and compared from the aspects of chemical composition, molecular weight, monosaccharide composition, appearance, DPPH free radical scavenging rate and α-amylase inhibition rate. Results: CWP-F had the highest molecular weight and was mainly composed of galactose and arabinose, CWP-P was mainly …

Extraction Of Active Ingredients From Penthorum Chinense Pursh And Comparison Of Component Distribution In Different Parts, Xiang Zhuoya, Zhu Boyu, Zhu Yongqing, Xia Chen, Chen Song

Food and Machinery

Objective: This study aimed to determine the extraction solvent and compare the distribution of functional ingredient and antioxidant activities in different parts of Penthorum chinense pursh. Methods: the total phenolic content, total flavonoid content, antioxidant capacity and individual phenolic compounds content in Penthorum chinense pursh were determined and analyzed. Results: The total phenolic content, total flavonoid content increased and then decreased with the increase of solvent concentration. The seven main phenolic compounds （catechin, rutin, pinocembrin-7-O-glucoside, quercetin, kaempferol, pinocembrin and thonningianin A）, ABTS radical scavenging ability, and ferric ion reduction ability were the highest in 80% ethanol extract. The …

Comparative Study On Several Black Bean Components, Antioxidant And Enzyme Inhibition In Vitro, Dang Yuting, Zhang Yan, Jing Boxing, Su Xiaomeng, Chai Xiyan

Food and Machinery

Objective: The difference in bioactive substance content and bioactivity in black beans were compared. Methods: The contents of total phenolic acids, total flavonoids, condensed tannins, total anthocyanins, total polysaccharides and total proteins of nine kinds of black beans were determined. The antioxidant activities of black bean extracts in vitro and their inhibitory effects on α-amylase, pancreatic lipase, acetylcholinesterase and tyrosinase were compared. Results: The contents of total phenolic acid, total flavonoids, condensed tannins and total anthocyanins were as follows: equine bean > small black bean > black bean; Total polysaccharide content: small black bean > black bean > horse bean; Total protein content: horse …

Design A Friendly Nanoscale Chemical Sensor Based On Gold Nanoclusters For Detecting Thiocyanate Ions In Food Industry Applications, Reham Ali, Sayed M Saleh

Faculty, Staff and Student Publications

The surfactant cetyltrimethylammonium bromide (CTAB) induces the aggregation of gold nanoclusters (GNCs), leading to the development of a proposed fluorometric technique for detecting thiocyanate (SCN-) ions based on an anti-aggregation mechanism. This approach is straightforward to execute, highly sensitive, and selective. A significant quenching effect occurs in fluorescence upon using the aggregation agent CTAB in GNCs synthesis, resulting in a transition from intense red fluorescence to dim red. The decrease in fluorescence intensity of GNCs in the presence of CTAB is caused by the mechanism of fluorescence quenching mediated by aggregation. As the levels of SCN- rise, the fluorescence of …

Financial Hardship And Neighborhood Socioeconomic Disadvantage In Long-Term Childhood Cancer Survivors, Alex J Fauer, Weiyu Qiu, I-Chan Huang, Patricia A Ganz, Jacqueline N Casillas, Gregory T Armstrong, Rebecca Howell, Carrie R Howell, Anne C Kirchhoff, Yutaka Yasui, Paul C Nathan

Faculty, Staff and Student Publications

Background: Long-term survivors of childhood cancer face elevated risk for financial hardship. We evaluate whether childhood cancer survivors live in areas of greater deprivation and the association with self-reported financial hardships.

Methods: We performed a cross-sectional analysis of data from the Childhood Cancer Survivor Study between 1970 and 1999 and self-reported financial information from 2017 to 2019. We measured neighborhood deprivation with the Area Deprivation Index (ADI) based on current zip code. Financial hardship was measured with validated surveys that captured behavioral, material and financial sacrifice, and psychological hardship. Bivariate analyses described neighborhood differences between survivors and siblings. Generalized linear …

Relationship Of Stress And Other Factors With Emotional Eating Among Adolescents In Depok, Muthia Syifa Rahmadina, Asih Setiarini

Indonesian Journal of Public Health Nutrition (IJPHN)

Emotional eating is an overeating behavior as a coping mechanism for negative emotions that emerges in adolescence. Emotional eating causes obesity, eating disorders, and non-communicable diseases. This study aims to determine the relationship between stress, body image, peer influence, parental rearing styles, social media use, sex, sleep quality, and emotion regulation with emotional eating among adolescents at senior high school in Depok. This cross-sectional quantitative study was conducted online in March 2022. The samples were grade X and XI students from senior high school in Depok who were chosen by using purposive sampling techniques (n=174). Chi X2 test and Mann …

Determinant Factors Of The Incidence Of Low Birth Weight In Central Java Province: Analysis Of 2018 Basic Health Research Data, Desi Irawati, Ratu Ayu Dewi Sartika, Diah Mulyawati Utari, Fadila Wirawan

Indonesian Journal of Public Health Nutrition (IJPHN)

Low birth weight (LBW) is a global public health issue with significant short and long-term consequences for individuals and societies. This study aims to examine the most dominant risk and variations in the proportion of LBW based on fetal factors, maternal and obstetric factors, and sociodemographic factors among toddlers in Central Java Province, utilizing the 2018 Basic Health Research (RISKESDAS) data. The study used a cross-sectional study conducted on 4255 samples, utilizing univariate, bivariate (chi-square), and multivariate analysis (multiple logistic regression). Central Java has the 3rd highest number of LBW cases in Indonesia with a prevalence of 6.1%. However, univariate …

Sugar-Sweetened Beverages Consumption Based On Individual And Environmental Factors Among The Faculty Of Public Health Universitas Indonesia’S Students In 2023, Safira Diva Aranis, Wahyu Kurnia Yusrin Putra, Asih Setiarini, Teguh Jati Prasetyo

Indonesian Journal of Public Health Nutrition (IJPHN)

Sugar-sweetened beverages (SSB) are beverages that contain added sugars. Excessive consumption of SSB can have an impact on health. Some of the effects caused by SSB include obesity, fatty liver, type II diabetes, hypertension, heart disease, nutritional deficiencies, and dental caries. This research aims to determine the differences in the proportion of SSB consumption based on individual and environmental factors among students of the Faculty of Public Health UI (FPH UI) in 2023. This study uses a cross sectional design with a sample size of 194 individuals. The researcher collected data including respondent’s identities, habits of reading food labels, knowledge …

The Differences In Maternal Clean And Healthy Living Behavior In The Incidence Of Stunting In Yogyakarta, Shafa Ramadhita, Anindhita Syahbi Syagata, Nor Eka Noviani

Indonesian Journal of Public Health Nutrition (IJPHN)

An indirect cause of stunting is maternal behavior. Moreover, good nutritional knowledge relates to good nutritional behaviors. Maternal clean and Healthy Living Behavior (PHBS) in daily life can reduce the risk of infectious diseases and be role models for children in implementing their future health behavior. The study aims to investigate the differences in PHBS of mothers in the incidence of stunting ages 24-59 months in the Minggir Primary Health Center working area. The cross-sectional approach of this research was conducted from March to April 2023. The subjects of this study were 69 respondents selected by cluster random sampling. The …

Factors Associated With Wasting In Toddlers Aged 6 – 59 Months At Cimpaeun Village, Depok City, West Java, Indonesia In 2023, Early Vici Azmia, Triyanti Triyanti

Indonesian Journal of Public Health Nutrition (IJPHN)

The prevalence of wasting under five in Indonesia in 2022 is 7.7%; according to WHO, this wasting problem is a serious public health problem. Wasting is a nutritional problem in toddlers that has an impact on morbidity and mortality. The research objective was to determine the factors associated with wasting in toddlers aged 6–59 months in Cimpaeun Village in 2023. The dependent variable is wasting, and the independent variables are birth weight, history of fever, diarrhea, acute respiratory infection, energy intake, carbohydrate intake, protein intake, fat intake, mother’s age, pregnancy, mother’s education level, mother’s nutritional knowledge, and family income. This …

The Relationship Of Energy And Nutrient Intake From Eating Out And Eating At Home On Blood Hemoglobin Levels In Adolescents, Adinda Aisyah Putri, Khoirul Anwar

Indonesian Journal of Public Health Nutrition (IJPHN)

Eating out of home is a common practice in adolescents. The high frequency of eating out of home characterized by higher intakes of energy, fats, sugar, and sodium. anemia, especially iron deficiency anemia which is characterized by blood hemoglobin levels, is still a nutritional problem in Indonesia in adolescents which can have an impact on adolescent health. The aim of this study was to determine the relationship between eating out and hemoglobin levels in adolescents in Jakarta. This research is an observational study with a cross sectional research design. The subjects of this research were female students aged 15-17 years. …

In Vitro And In Vivo Fermentation Models To Study The Function Of Dietary Fiber In Pig Nutrition, Weikang Huangfu, Hexi Cao, Shouren Li, Shuhang Zhang, Mengqi Liu, Boshuai Liu, Xiaoyan Zhu, Yalei Cui, Zhichang Wang, Jiangchao Zhao, Yinghua Shi

Animal Science Faculty Publications and Presentations

The importance of dietary fiber (DF) in animal diets is increasing with the advancement of nutritional research. DF is fermented by gut microbiota to produce metabolites, which are important in improving intestinal health. This review is a systematic review of DF in pig nutrition using in vitro and in vivo models. The fermentation characteristics of DF and the metabolic mechanisms of its metabolites were summarized in an in vitro model, and it was pointed out that SCFAs and gases are the important metabolites connecting DF, gut microbiota, and intestinal health, and they play a key role in intestinal health. At …

Association Between Monosodium Glutamate Consumption With Changes In Gut Microbiota And Related Metabolic Dysbiosis—A Systematic Review, Hossein Ahangari, Behnam Bahramian, Arezou Khezerlou, Milad Tavassoli, Narges Kiani-Salmi, Vahideh Tarhriz, Ali Ehsani

School of Medicine Faculty Publications

Monosodium glutamate (MSG) is used as a common food additive in some foods. However, based on our search and knowledge, no comprehensive study discussed the effect of MSG on the human gut microbiome. In this study, the effects of MSG on the gut microbiome, liver, and kidney were performed. Data were collected from databases including PubMed, Scopus, Web of Science, and ScienceDirect using the search strategy and keywords. Finally, 14 eligible studies were selected for systematic review. This study provides a new perspective on the effects of MSG on the gut flora, shedding light on the potential relationship between MSG …

5-Ht Neurons Integrate Gaba And Dopamine Inputs To Regulate Meal Initiation, Kristine M Conde, Hueyzhong Wong, Shuzheng Fang, Yongxiang Li, Meng Yu, Yue Deng, Qingzhuo Liu, Xing Fang, Mengjie Wang, Yuhan Shi, Olivia Z Ginnard, Yuxue Yang, Longlong Tu, Hesong Liu, Hailan Liu, Na Yin, Jonathan C Bean, Junying Han, Megan E Burt, Sanika V Jossy, Yongjie Yang, Qingchun Tong, Benjamin R Arenkiel, Chunmei Wang, Yang He, Yong Xu

Children’s Nutrition Research Center Staff Publications

Obesity is a growing global health epidemic with limited effective therapeutics. Serotonin (5-HT) is one major neurotransmitter which remains an excellent target for new weight-loss therapies, but there remains a gap in knowledge on the mechanisms involved in 5-HT produced in the dorsal Raphe nucleus (DRN) and its involvement in meal initiation. Using a closed-loop optogenetic feeding paradigm, we showed that the 5-HTDRN→arcuate nucleus (ARH) circuit plays an important role in regulating meal initiation. Incorporating electrophysiology and ChannelRhodopsin-2-Assisted Circuit Mapping, we demonstrated that 5-HTDRN neurons receive inhibitory input partially from GABAergic neurons in the DRN, and the 5-HT response to …

Pathogenesis And Therapeutic Considerations For Nonalcoholic Fatty Liver Disease, Elijah Chung

Senior Honors Theses

A product of the Westernized, high-fat diet, non-alcoholic fatty liver disease (NAFLD) has emerged as the leading cause of chronic liver disease, affecting one-fourth of the world's population. NAFLD is a progressive disease arising from a multisystem response to excess lipids in the blood, adipose tissue, and liver. Despite the prevalence of NAFLD and its well-studied bidirectional association with obesity and type 2 diabetes mellitus and obesity, there is a shocking scarcity of available treatments aside from diet and lifestyle changes. Thus, further research on NAFLD and potential therapies is urgently needed. This paper will illustrate the major pathways associated …

Comprehensive Analysis Of Bulk And Single-Cell Transcriptomic Data Reveals A Novel Signature Associated With Endoplasmic Reticulum Stress, Lipid Metabolism, And Liver Metastasis In Pancreatic Cancer, Xing Wang, Minzhi Gu, Feihan Zhou, Ruiling Xiao, Xiyuan Luo, Lei You, Yupei Zhao

Faculty, Staff and Student Publications

BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) is a lethal malignancy with high probability of recurrence and distant metastasis. Liver metastasis is the predominant metastatic mode developed in most pancreatic cancer cases, which seriously affects the overall survival rate of patients. Abnormally activated endoplasmic reticulum stress and lipid metabolism reprogramming are closely related to tumor growth and metastasis. This study aims to construct a prognostic model based on endoplasmic reticulum stress and lipid metabolism for pancreatic cancer, and further explore its correlation with tumor immunity and the possibility of immunotherapy.

METHODS: Transcriptomic and clinical data are acquired from TCGA, ICGC, and GEO …