Digital Commons Network^™

Could Psilocin Rescue Chronic, Stress-Accelerated, Transcriptional Aging In Brain?, Danny R. Craig, Eric M. Blalock

Journal of Pharmacology & Nutritional Sciences

Brain aging (BA) processes are complex, often affect multiple systems, and frequently lead to cognitive decline and increased susceptibility to insults. BA appears to be a primary risk for the development of many prominent neurodegenerative pathologies. The US Census Bureau predicts that the aging population (65+) will represent a greater proportion of the US population than children (under 18) by 2034, dramatically increasing the burden on health-care infrastructure.¹⁷ Several mechanisms of stress driven, aging-related neurologic dysfunction have been advanced in the past 50 years and include: Stress hormone exposure and glucocorticoid cascade;^{7, 16} calcium ion dyshomeostasis;⁸ allostatic …

Effects Of Short-Term Rotations Of Monocultures And Mixtures Of Legumes And Grasses With Rice In The Subtropical Zone Of South-Western China, S R. Zhou, Y G. Yu, K Mao, X M. Gan, Z L. Pu

IGC Proceedings (1977-2023)

Five short-term rotation systems of monocultures and mixtures of legumes and grasses with rice, i.e., Medicago hispida ➔ rice, Trifolium repens cv. Ladino ➔ rice, Astragalus sinicus + lolium multiflorum ➔ rice, Medicago hispida + Lolium multiflorum ➔ rice and Trifolium repens cv. Ladino + Lolium multiflorium ➔ rice, were selected from 8 evaluated in this study in the subtropical zone of south-western China. The average results for these rotational types per year were: forage dry matter 3,63 tlha, forage crude protein 727 .5 kg/ha, metabolisable energy 22.lx!03 MJ/ha, in vitro organic matter digestibility of forages 72.84%, rice yield 7.4 …

Potential Of Crotalaria Ochroleuca (Marejea) In Traditional Crop And Livestock Production Systems In Tanzania, S V. Sarwatt

IGC Proceedings (1977-2023)

In experiments to study the role of Crolalaria ochrroleuca (marejea) in traditional farming systems, the plant was used in the following way: (l) broadcast alone at a rate of 10 kg/ha of seed to determine dry matter (DM) yield, nutritive value and kg N/ha it can fix at different stages of growth, i.e., 2, 4, 6, 8, IO, 12, 14 and 16 weeks. (2) sown under after 3 weeks on alternate ridges with maize and maize alone as control. (3) the leaves at 10 weeks were harvested and supplemented to young sheep grazing 8 h/day. 12 male sheep …

Sesbania Sesban: A Promising Forage Legume In Semi-Arid Central Tanzania, D N. Msariri, M L. Kusekwa

IGC Proceedings (1977-2023)

Seventy-four accessions of Sesbania sesban were evaluated alongside 7 of S. goetzel for forage production at Mpwapwa, In Tanzania. The former was promising while the latter was generally unsuccessful. For S. sesban, germination of scarified inoculated seed in nursery was 34%. Survival of the seedlings was 96% at transplanting at 8 weeks. Growth in the field, measured in terms of mean incremental height, was 2.9 m at l year of establishment. On average, 50% of the plants flowered and formed pods at 158 and 190 days, respectively. Seed yield averaged 348 g per plant, while forage yield averaged 4.5 t …

Analysis Of Growth Characteristics And Evaluation As Fodder Resources Of Tropical Leguminous Browses In Subtropical Area In Japan, Y Kawamoto, M Honma

IGC Proceedings (1977-2023)

To evaluate the potential of several tropical leguminous browse species as fodder plants in the subtropical area of Japan, the dry matter yield and quality and resistance to clipping and drought in the first year were examined and compared in browse species. Species such as Deamodiwn tortuoaum, Desmodium discolor, Aeschynomene villosa and herbaceous Stylosanthes guianensis, had relatively high water stress tolerance, All the species were resistant to clipping. The species such as Desmodium tortuosum. Desmodium discolor among Desmodium genus have high potential for dry matter production and nutritive value in this region.

Agronomic Evaluation Of Centrosema Germplasm On Acid Utisol In The Humid Tropics Of Peru. Ii. Centrosema Tetragonolobum Schultze-Kraft & Williams, Gerhard Keller-Grein

IGC Proceedings (1977-2023)

The agronomic potential of 11 accessions of Centrosema tetragonolobum was assessed In a small-plot clipping trial conducted near Pucallpa, Peru. These accessions were compared with 8 selected accessions of C. acutifolium, C, brasilianum and C. macrocarpum, and 3 accessions of the agronomically little-known C. brachypodum and C. capitatum. All C. tetragonolobum accessions were well adapted to an acid ultisol (pH 4.S, 80% Al saturation). Several of them produced dry matter and seed yields similar to those of promising lines of C. acutifolium and C. macrocarpum, The capacity to root at trailing stems was poor for C. tetragonolobum …

Epigenetic Landscapes Of Aging In Breast Cancer Survivors: Unraveling The Impact Of Therapeutic Interventions-A Scoping Review, Nikita Nikita, Zhengyang Sun, Swapnil Sharma, Amy L Shaver, Victoria Seewaldt, Grace Lu-Yao

Department of Medical Oncology Faculty Papers

Breast cancer therapies have dramatically improved survival rates, but their long-term effects, especially on aging survivors, need careful consideration. This review delves into how breast cancer treatments and aging intersect, focusing on the epigenetic changes triggered by chemotherapy, radiation, hormonal treatments, and targeted therapies. Treatments can speed up biological aging by altering DNA methylation, histone modifications, and chromatin remodeling, affecting gene expression without changing the DNA sequence itself. The review explains the double-edged sword effect of therapy-induced epigenetic modifications, which help fight cancer but also accelerate aging. Chemotherapy and targeted therapies, in particular, impact DNA methylation and histone modifications, promoting …

Impact Of Fresh-Cut Onion Types And Flavonoid Profiles On The Survival Kinetics Of Foodborne Pathogen During Refrigerated Storage, Veerachandra Yemmireddy, Matthew Mancias

School of Earth, Environmental, & Marine Sciences Faculty Publications

This study investigated the effect of onion flavonoid profiles on the growth, survival, and/or death kinetics of foodborne pathogens in fresh-cut onions at 4 °C. Fresh-cut white, yellow, red, and sweet onions were inoculated with separate four-strain cocktail(s) of nalidixic acid-adapted Salmonella spp., Escherichia coli O157:H7, and Listeria monocytogenes achieving a 4 to 5 log CFU g−1. The samples were stored in clam shell containers at 4 °C and 70 ± 2 % relative humidity for 14 days. Additionally, flavonoid profiles were determined on uninoculated control samples stored under similar conditions using standard chromatography techniques, with quercetin derivatives identified as …

Associations Among Shopping Methods, Diet Adherence, And Nutrition Knowledge Of Employed Primary Grocery Shoppers In Households With Children, Baylee Schneider

Master's Theses

Obesity is a prominent risk factor for chronic disease, which is the leading cause of death in the United States. Obesity and chronic disease rates continue to rise, requiring a need for prevention and intervention efforts. The future role of dietetics is to provide treatment and prevention through holistic approaches, by understanding individuals’ habits that contribute to the onset of disease, specifically their food choices, grocery shopping methods, and influences that waver these selections. The purpose of this study is to evaluate the relationship between grocery shopping methods (online or in-store), Mediterranean diet adherence, nutrition knowledge, and food purchase patterns …

Protein Digestibility Impacted By Bacillus Coagulans, Pasteurization And Protein Source In Ready-To-Drink Protein Beverages, Samantha L. Bass, Samantha L. Bass

Master's Theses

The goal of this study was to assess how to maximize the digestibility of protein in protein beverages utilizing various protein sources, differing temperature/storage combinations, and the addition of probiotics (Bacillus coagulans). The protein sources used included 3 milk proteins and 2 plant protein sources (micellar casein, milk protein concentrate, reduced-calcium milk protein concentrate, pea protein isolate, and soy protein isolate). Soy protein isolate was chosen because it is readily available and commonly used as a plant protein alternative. Pea protein isolate was chosen because it is a non-allergen, and similarly, it is readily available. Milk protein concentrates …

Comparison Of Caregiver-Reported Dietary Intake Methods In Zellweger Spectrum Disorder, Mousumi Bose, Nancy L. Von Thun, Adrian L. Kerrihard, Melisa L. Lopez, Chelsea I. Donlon, Alyssa K. Smolen, Nicole P. Fontes

Department of Nutrition and Food Studies Scholarship and Creative Works

Background/Objectives: Zellweger spectrum disorder (ZSD), a rare genetic disease characterized by defects in peroxisome biogenesis, results in dysfunction of all organ systems, including feeding difficulties, gastrointestinal bleeding, and reduced overall growth. Despite this nutritional impact, no published studies have assessed dietary intake in ZSD. The purpose of this study was to determine nutrient intake in individuals with ZSD or a related peroxisomal disorder using two methods of dietary assessment as provided by family caregivers. Methods: Family caregivers participated in multiple 24 h dietary recall interviews and completed 3-day food records for their child with ZSD or a related single-enzyme peroxisomal …

An Exploratory Case Study Of A Community Food Pantry In Northwest Louisiana, Abigail Clair Henington

Master's Theses

Many individuals are struggling with food insecurity in Louisiana; according to the Louisiana Food Bank Association's website, Feeding Louisiana’s 2023 impact report, an estimated 683,100 people in Louisiana experience food insecurity. In northwest Louisiana, 30% of the population lives below the poverty line, with an average income of $34,485 per household. Common Ground is a nonprofit community outreach program in Northwest Louisiana, specifically Shreveport. The program has been in operation for over 20 years and strives to provide a place free of judgment and a place of common ground for those in the Cedar Grove community. Each week, they have …

Impact Of Polysaccharides On Advancing Plant-Based Meat Alternatives, Prashant Dahal, Clifford Hall, Srinivas Janaswamy

Dairy Science and Food Science Faculty Publications: 2022 to Present

Plant-based meat products are a valued choice for vegetarians and others. Their production has been perceived as an innovation promoting animal welfare and sustainability. However, there are challenges in simulating desirable appearance, texture, and flavor using only plant-based protein sources. Polysaccharide addition during the formulation and texturization of plant proteins can improve the physi- cochemical and sensory properties of texturized protein products. In this regard, a clear understanding of the fundamental properties of polysaccharides is essential for transforming plant proteins into fibers or nonfilamentous protein aggregates. Enhancing water-holding capacity, gelation, and binding functionality is crucial for overcoming structural and textural …

A Preliminary Report Of The Carotenoid Assessment In Adults 50 Years Of Age And Older In Louisiana, Mary-Catherine Feazell

Master's Theses

Fruits and vegetables are at the core of a healthy, balanced diet. They assist in preventing the development of chronic diseases such as hypertension, diabetes, cardiovascular disease, and cancer (Fadnes, et al., 2022). Aging is a natural biological process followed by disease, cognitive impairment, and a natural decline of the body’s ability to perform at its best. The older adult population is currently the fastest-growing population globally (El-Shebiney et al., 2022). Vitamin A is crucial for several parts of the body to function correctly. Despite the positive effects of Vitamin A on the body, the recommended dietary intake is not …

2025 Little International Agricultural Exposition Catalog, Little International Agricultural Exposition South Dakota State University

Little International "Little I" Agricultural Exposition Catalogs

This is the catalog for the 102nd Little International 'Little I' Agricultural Exposition, held on March 28 & 29, 2025.

Self-Mustering Yards For Pastoral Livestock Management, Department Of Primary Industries And Regional Development, Western Australia

Animal production and livestock factsheets

Self-mustering yards (SMYs) are an important component of effective total grazing management in the pastoral regions. These yards are used to self-muster cattle, sheep and goats, as well as native browsers and feral animals as they enter the yards to access the water point.

Nebline, March/April 2025

NEBLINE Newsletter Archive from Nebraska Extension in Lancaster County

Be Groundwater Aware in Your Day-to-Day Life! Becky Schuerman

National Groundwater Awareness Week, March 9-15, 2025

National Nutrition Month: Food Connects Us, Alyssa Havlovic

Recipe of the Month: Wild Vegetable Salad, Alyssa Havlovic

Prepare Your Landscape’s Spring Game Plan, Sarah Browning

Garden Guide: Things to Do This Month, Mary Jane Frogge

2025 GROBigRed

Embracing the Puddle: The Joy of Rainy Day Outdoor Play, Hayley Jackson Perez

Agronomic Practices to Reduce Nitrate Losses to Groundwater, John Nelson

Ethan & Morgan Gabel Attend National 4-H Congress

4-H Horse Teams at Nationals

Teen Council 4-H’ers Team Up to Lead Overnight Lock-in

Heart of …

Applications Of Archaeal Antioxidant Coenzyme M As An Agricultural Biostimulant, Jeremy Hunter Brown

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

As the demand to meet global food security goals continue to increase, the need to increase efficiency and productivity of agricultural output also rises. This calls for innovative and cost-effective methods for improving plant growth and yield. Here we explore how antioxidants, molecules that inhibit oxidation and are necessary for redox based signaling and redox homeostasis, can be utilized as chemical biostimulants. Specifically, we investigated Coenzyme M, an antioxidant from archaea that holds potential economic advantages over other antioxidants. Chapter 1 provides a comprehensive review of antioxidants and how exogenously application of them affects plant growth and biology, highlighting the …

Insulin Receptor Responsiveness Governs Tgfβ-Induced Hepatic Stellate Cell Activation: Insulin Resistance Instigates Liver Fibrosis, Wang-Hsin Lee, Evelyn A. Bates, Zachary A. Kipp, Sally Pauss, Genesee J. Martinez, Cheavar A. Blair, Terry D. Hinds Jr.

Markey Cancer Center Faculty Publications

The insulin receptor (INSR) has been shown to be hyperactive in hepatic stellate cells (HSCs) in humans and rodents with liver fibrosis. To explore HSC cellular mechanisms that INSR regulates during pro-fibrotic stimulation, we used CRISPR-Cas9 technology. We knocked out a portion of the INSR gene in human LX2 HSC cells (INSRe5- 8 KO) that regulates insulin responsiveness but not the insulin-like growth factor (IGF) or transforming growth factor-β (TGFβ) signaling. The INSRe5- 8 KO HSCs had significantly higher cell growth, BrdU incorporation, and lower TP53 expression that suppresses growth, and they also exhibited increased migration compared to the Scramble …

Exploring Oxylipins In Host–Microbe Interactions And Their Impact On Infection And Immunity, Robert J. Neff, Christopher D. Radka

Markey Cancer Center Faculty Publications

Plasma lipids are essential components of biological systems, transported through interactions with proteins to maintain cellular functions. These lipids exist in various forms, such as fatty acids, glycerolipids, glycerophospholipids, sphingolipids, sterols, and prenol lipids, derived from dietary intake, adipose tissue, and biosynthesis. While the association between certain fatty acids and cardiovascular diseases has been widely recognized, polyunsaturated fatty acids (PUFAs) exhibit cardioprotective effects, reducing risks of arrhythmias and heart-related mortality. This is due to their role in the production of eicosanoids, which modulate inflammation. Chronic inflammation, particularly in obesity, is significantly influenced by fatty acids, with saturated fatty acids promoting …

Overexpression And Biophysical And Functional Characterization Of A Recombinant Fgf21, Phuc Phan, Jason Hoang, Thallapuranam Krishnaswamy Suresh Kumar

Chemistry & Biochemistry Faculty Publications and Presentations

Fibroblast growth factor 21 (FGF21) is an endocrine FGF that plays a vital role in regulating essential metabolic pathways. FGF21 increases glucose uptake by cells, promotes fatty acid oxidation, reduces blood glucose levels, and alleviates metabolic diseases. However, detailed studies on its stability and biophysical characteristics have not been reported. Herein, we present the overexpression, biophysical characterization, and metabolic activity of a soluble recombinant FGF21 (rFGF21). The far-UV circular dichroism spectra of rFGF21 show a negative trough at 215 nm, indicating that the protein’s backbone predominantly adopts a β sheet conformation. rFGF21 shows intrinsic tyrosine fluorescence at 305 nm. Thermal …

The Wellness Connection March 2025, Roger Williams University School Of Law Office Of Student Life

Life of the Law School (1993- )

No abstract provided.

Dairy & Food Science News, March 2025, Department Of Dairy And Food Science

Dairy & Food Science News

Message from the Department Head
Faculty & Staff Updates
Department Faculty Earn Awards
Midwest Regional Dairy Challenge Competition hosted by SDSU
Small-Scale Dairy Processing Project
Recruitment Updates & Opportunities
Recent Activity
Alumni Mentorship Program
SDSU Food Science Research in the News
Student Updates
Events & Calendar

Wayne E. Sabbe Arkansas Soil Fertility Studies 2024, Nathan A. Slaton

Arkansas Agricultural Experiment Station Research Series

Rapid technological changes in crop management and production require that the research efforts be presented in an expeditious manner. The contributions of soil fertility and fertilizers are major production factors in all Arkansas crops. The studies described within will allow producers to compare their practices with the university’s research efforts. Additionally, soil-test data and fertilizer sales are presented to allow comparisons among years, crops, and other areas within Arkansas.

Evolution Of Mate Guarding Intensity In Crickets As A Possible Adaptation To Sexual Conflict Over Sperm Transfer, Bert Foquet, Jack Thomas Mckermitt, John Hunt, Ben M. Sadd, Scott K. Sakaluk

Faculty Publications – Biological Sciences

Mate guarding is a common behavioral adaptation in males to ensure mating or to hinder current partners from remating with rival males. In the decorated cricket, Gryllodes sigillatus, males transfer a spermatophore to females at mating, comprising a sperm-containing ampulla enveloped in a large gelatinous mass, the spermatophylax, that serves as a nuptial food gift for the female. Males guard the female while she feeds on the nuptial gift and while sperm are evacuated from the ampulla into her reproductive tract. Mate guarding behavior functions to prevent competitors from mating with the female but may also represent a behavioral …

Safety And Efficacy Of Dtx401, An Aav8-Mediated Liver-Directed Gene Therapy, In Adults With Glycogen Storage Disease Type I A (Gsdia), David A Weinstein, Terry G Derks, David F Rodriguez-Buritica, Ayesha Ahmad, María-Luz Couce, John J Mitchell, Rebecca Riba-Wolman, Malaya Mount, Julieta Bonvin Sallago, Katalin M Ross, Melanie M Van Der Klauw, Foekje De Boer, Caroline Van Der Schaaf, Heather Saavedra, Miguel Martínez-Olmos, Elvis Atanga, Asad Hosseini, Deepali Mitragotri, Eric Crombez

Faculty, Staff and Student Publications

Glycogen storage disease type Ia (GSDIa) is a rare, life‐threatening, inherited carbohydrate metabolism disorder caused by glucose‐6‐phosphatase (G6Pase) deficiency, which is essential for glycogenolysis and gluconeogenesis. GSDIa management includes a strict medically prescribed diet that typically includes daily uncooked cornstarch doses, including overnight, to maintain euglycemia. DTX401 is an investigational adeno‐associated virus serotype 8 vector expressing the human G6PC1 gene that encodes G6Pase. This open‐label, phase 1/2, dose‐escalation, 52‐week gene therapy trial evaluated the safety and efficacy of a single DTX401 infusion in 12 adults with GSDIa (ClinicalTrials.gov Identifier: NCT03517085). Three participants in Cohort 1 received DTX401 2.0 × …

Safety And Antitumor Activity Of A Novel Acd25 Treg Depleter Rg6292 As A Single Agent And In Combination With Atezolizumab In Patients With Solid Tumors, Valentina Gambardella, Michael Ong, Maria E Rodriguez-Ruiz, Jean-Pascal Machiels, Miguel F Sanmamed, Vladimir Galvao, Anna Spreafico, Daniel J Renouf, Stephen J Luen, Rachel Galot, Bernard Doger De Spéville, Emiliano Calvo, Aung Naing, Samira Curdt, Theresa Maria Kolben, Eva Rossmann, Tamara Tanos, Kevin Smart, Maria Amann, Yuying Xie, Linxinyu Xu, Enrique Gomez Alcaide, Nicolas Städler, Nicole Justies, Christophe Boetsch, Vaios Karanikas, Gabriel Schnetzler, Kristoffer S Rohrberg

Faculty, Staff and Student Publications

Purpose: Therapeutic depletion of immunosuppressive regulatory T cells (Treg) may overcome resistance to cancer immunotherapies. RG6292 is an anti-CD25 antibody that preferentially depletes Tregs while preserving effector T-cell functions in preclinical models. The safety, pharmacokinetics, pharmacodynamics, and antitumor efficacy of selective Treg depletion by RG6292 administered as monotherapy or in combination with atezolizumab were evaluated in two phase I studies.

Patients and methods: Adult patients with advanced solid tumors were administered intravenous RG6292, given every 3 weeks alone (study 1: NCT04158583, n = 76) or with 1,200 mg atezolizumab every 3 weeks (study 2: NCT04642365, n = 49). …

Beyond Nutrition: Exploring Immune Proteins, Bioactive Peptides, And Allergens In Cow And Arabian Camel Milk, Manujaya W. Jayamanna Mohottige, Angéla Juhász, Mitchell G. Nye-Wood, Katherine A. Farquharson, Utpal Bose, Michelle L. Colgrave

Research outputs 2022 to 2026

Bovine milk has dominated the dairy segment, yet alternative milk sources are gaining attention due to perceived superior health benefits, with immune proteins and bioactive peptides (BPs) contributing to these benefits. Fractionation affects protein recovery and composition. Here, the cream fraction resulted in the highest yield of proteins, identifying 1143 camel and 851 cow proteins. The cream fraction contained a significantly higher concentration of immune system-related proteins. Straightforward filtration and protein precipitation methods achieved average BP detections of 170 and 177, compared to 31 by a solvent-solvent extraction method. Considering potentially allergenic proteins, 53 (camel) and 52 (cow) were identified. …

Assessment Of Physiological & Biochemical Changes In Tomato Plants Treated With Plant Growth Promoting Rhizobacteria (Pgpr) Under Salinity Stress Conditions, Mohammed Sharif Alhosani

Theses

Plant growth-promoting rhizobacteria (PGPRs) can effectively mitigate the negative impacts of salt stress on plants. The present study reports the isolation of PGPRs from a high-saline mangrove ecosystem in Abu Dhabi, with isolates exhibiting ACC deaminase (ACCD) activity to reduce stress-induced ethylene, along with additional plant growth-promoting (PGP) characteristics, including phosphate solubilization (P+). A total of 57 salt-tolerant bacterial isolates from the mangrove rhizosphere were initially screened for ACCD and P+ activities. Of these, 24 isolates tested positive for PGP characteristics and were further evaluated for their ability to enhance salt stress tolerance in tomato seedlings. In addition, seedlings inoculated …

Global Review Of Consumer Preferences And Willingness To Pay For Edible Insects And Derived Products, Zewdu Abro, Kibrom T. Sibhatu, Gebeyehu Manie Fetene, Mohammed Hussen Alemu, Chrysantus M. Tanga, Subramanian Sevga, Menale Kassie

All Peer-Reviewed Publications

The rising global demand for protein, driven by population growth, urbanization, economic development, and climate change, underscores the need for sustainable alternative protein sources. Edible insects have emerged as a viable solution to enhance foodfeed and nutritional security while contributing to waste management. This study reviews 128 peer-reviewed publications to assess consumer preferences and willingness to pay (WTP) for edible insects and their derivatives. Findings reveal that studies predominantly focus on Europe and insect-based foods, with limited research on insect-based feeds and derived products. Consumers in Africa, Asia, and Latin America show higher acceptance of insect-based food compared to those …