Digital Commons Network^™

Circadian Rhythms And Neuroendocrine Dysregulation In Adhd: Therapeutic Insights From Omega-3 Fatty Acids, Ayesha Zafar Iqbal, Patricia Marest Suwindi, Sunny Yin-Shan Chen, Lindsay Liang-Tien Cho, Kuan-Pin Su, Jane Pei-Chen Chang

BioMedicine

Attention-deficit hyperactivity disorder (ADHD) is a common neurodevelopmental condition often accompanied by circadian rhythm disturbances, particularly delayed sleep phase. These involve superchiasmatic nucleus (SCN) dysregulation, altered melatonin secretion, and hypothalamic–pituitary–adrenal (HPA) axis activity, which may be exacerbated by artificial light exposure. Genetic studies further implicate circadian mechanisms, linking ADHD with polymorphisms in clock genes such as PER and CLOCK.

Nutraceuticals, particularly omega-3 polyunsaturated fatty acids (n-3 PUFAs), have been proposed as modulators of circadian rhythms. N-3 PUFAs are essential for brain health and may influence melatonin synthesis and sleep–wake regulation. Preclinical and clinical findings suggest that supplementation can improve cognitive …

The Integrative Role Of Melatonin In Psychiatric Disorders: A Systematic Review Of Evidence From Circadian Biology, Lifestyle Medicine, And Psychoneuroimmunology, Ho Bao Chau Le, Kollawat Somsri, Thansita Bhunyakarnjanarat, Nattiya Hirankarn, Asada Leelahavanichkul

BioMedicine

Melatonin, a hormone produced by the pineal gland, is known for regulating circadian rhythms and has emerging therapeutic potential in psychiatric disorders. This systematic review examines evidence from clinical and preclinical studies to assess melatonin’s efficacy in the following conditions: depression, anxiety, bipolar disorder, and schizophrenia. Beyond its role in circadian regulation, melatonin exhibits antioxidative, anti-inflammatory, and immunomodulatory properties, which intersect with nutrition, lifestyle medicine, and psychoneuroimmunology (PNI).

The review finds that melatonin improves sleep quality, restores circadian balance, and modulates stress-related neuroimmune pathways. It also supports neuroplasticity and reduces oxidative stress, contributing to resilience against psychosocial and environmental stressors. …

From Rhythm To Resilience: The Interplay Of Circadian Rhythm, Melatonin, Lifestyle, Nutrition In Psychoneuroimmunology (Pni), Jane Pei-Chen Chang, Kuan-Pin Su

BioMedicine

Emerging evidence reveals that circadian rhythm, melatonin signaling, nutrition, and inflammation are intricately intertwined in shaping both mental and physical health. Circadian disruptions and lifestyle imbalances contribute to neuroinflammation, mood dysregulation, and cardiometabolic dysfunction, as seen in attention-deficit/hyperactivity disorder (ADHD), major depressive disorder (MDD), metabolic syndrome,and cardiovascular diseases. This special issue highlights interdisciplinary research that integrates circadian biology, nutrition, and psychoneuroimmunology (PNI) toward personalized and preventive psychiatry. Featured studies explore circadian and melatonin mechanisms in ADHD and MDD, the therapeutic and prophylactic potential of omega-3 polyunsaturated fatty acids (n-3 PUFAs), the neuroprotective potentical of paeoniflorin, and the role of extracellular …

Climate And Non-Genetic Effects On Goat Milk Quality And Casein Prediction Using Machine Learning, Ibrahima Mahamane Abdourhamane, Dilek Arsoy

The Thai Journal of Veterinary Medicine

Milk quality is becoming more and more crucial for farmers with the increasing use of component-based pricing systems in the sector. This study aimed to investigate the effects of climate-related and non-genetic factors on goat milk quality on the island of Northern Cyprus and to predict casein content using machine learning techniques. An analysis was performed on 21,695 goat milk samples collected between 2012 and 2018. Somatic cell count (SCC), standard plate count (SPC), and key milk components such as protein, casein, lactose, and fat were evaluated for different seasons, regions, farm sizes, and raw milk types. Five machine learning …

Workplace Policy And Associated Factors Of Minimum Acceptable Diet Practices: An Online Survey Among Working Mothers In Indonesia, Fadhila Iswi Deandra, Judhiastuty Februhartanty, Muchtaruddin Mansyur

Kesmas

Working mothers in Indonesia may influence complementary feeding practices, particularly their ability to ensure that their infants properly meet the minimum acceptable diet (MAD). In this cross-sectional study, an online survey was distributed through various online platforms where participants were recruited using convenience sampling. The questionnaire covered sociodemographic factors, workplace policies, and infant and young child feeding (IYCF) practices. Descriptive and logistic regression analyses were conducted. A total of 394 working mothers participated, of which over 90% of the respondents reported meeting minimum dietary diversity, minimum milk frequency, minimum milk feeding frequency, and MAD indicators as assessed with a standardized …

Red Midge Larvae Are An Invertebrate Alternative Diet To Beef Liver For Planarian Husbandry, Jonah Pacis , '25, Danielle Ireland, Evangeline Coffinas, Jerome Sheehan, Kate Sun , '27, Eva-Maria S. Collins

Biology Faculty Works

Freshwater planarians are an emerging model for toxicology and neuroscience because of their amenability to rapid behavioral screening and remarkable ability to regenerate a cephalized nervous system. As invertebrates, planarians can help reduce the use of vertebrates in research; however, laboratories typically maintain planarians on diets of homogenized organic beef or chicken liver, raising ethical concerns with feeding a vertebrate diet. Organic liver is difficult to obtain, and preparation methods vary, introducing intra- and interlaboratory variability. Here, we show that Dugesia japonica planarians can be maintained for over a year on commercially available red midge larvae (RML), a natural prey …

Biochar Derived From Different Sources Ameliorates The Phytochemical And Physiological Characteristics Of Foxtail Millet (Setaria Italica) Under Water Stress, Mohammad Keshavarz, Ehsan Bijanzadeh, Hamid Reza Boostani

Turkish Journal of Botany

Organic material, such as biochar, can improve soil fertility and crop yield under water stress. A pot experiment was conducted to consider the effects of biochar on the pigment content, enzyme activity, physiological characteristics, and nutrient uptake of foxtail millet under water stress. Plants were tested under normal, mild, and severe irrigation regimes (100%, 75%, and 50% field capacity, respectively) using different biochar sources (licorice root biochar (LRB), cow manure biochar (CMB), cotton residue biochar (CRB), and municipal waste biochar (MWB)) and a control without fertilizer. Under severe water stress, the chlorophyll a content and total chlorophyll increased by 137.3% …

Protective Role Of Salicylic Acid Against Abiotic Stresses In Horticultural Crops: A Review, Faisal Hayat, Xiaoyun Zhang, Mohammed Alyafei, Fareeha Shireen, Ummara Khan, Sumeera Asghar, Sezai̇ Erci̇şli̇, Karthishwaran Kandhan, Mohamed S. Sheteiwy, Yali Zhang, Xiaoyan Lu

Turkish Journal of Botany

Environmental stressors such as drought, floods, salinity, extreme temperatures, and heavy metal toxicity are major threats to horticultural plants because they disrupt plant physiological mechanisms, leading to reduced yield and quality. Salicylic acid (SA) is a plant hormone that regulates various physiological and biochemical functions in plants. Moreover, it regulates hormonal balance, enhances the absorption of essential nutrients, promotes photosynthesis and the production of antistress compounds, and improves stress resistance. This comprehensive review explains several physiological and biochemical activities that are affected by SA under stressful conditions, such as stomatal regulation, antioxidant defense systems, osmotic adjustment and gene expression regulation. …

Tannin Supplementation Alters Foraging Behavior And Spatial Distribution In Beef Cattle, Bashiri Iddy Muzzo, R. Douglas Ramsey, Kelvyn Bladen, Juan J. Villalba

Wildland Resources Student Research

Beef production on chemically uniform grass monocultures can limit nutrient synchrony and contribute to uneven pasture use. We evaluated whether supplementing tannins with bioactive plant secondary compounds improves foraging dynamics and landscape use by beef cattle grazing a meadow bromegrass monoculture in ways aligned with rangeland sustainability. Twenty-four Angus cow–calf pairs were allocated to six 3.6-ha paddocks (four pairs/paddock), randomly assigned to Control (Ctrl; n = 3) or Tannin treatment (TT; n = 3). Animals received 1 kg/cow/day of DDGs, with TT receiving an added 0.4% tannins (2:1 condensed:hydrolyzable). Grazing occurred during four 15-day periods (July– September) across two years. …

Nickel Toxicity To Safflower Seed Germination And Seedling Morphoanatomy, Uğurcan Baran, Sude Tanik, Mert Can Vardar, Güray Ülger, Ahmet Aksoy

Turkish Journal of Botany

The safflowers (Carthamus tinctorius L. cv Olas) grown hydroponically under nickel (Ni) stress were examined in this study. T he effects of 0, 0.75, 1, 3, 5, 10, and 15 mM Ni on seed germination rate, protein, and pigment content of germinating seeds were investigated. Also, the toxicity of 0.75 mM Ni on plant growth, malondialdehyde (MDA) amount, and anatomy of 21-day-old safflower seedlings were studied. Ni adversely affected the germination rate, radicle length, protein, and pigment content of safflower seeds, particularly when higher than 3 mM. It also negatively affected the biomass production, plant length, leaf number, and MDA …

The Effects Of Montelukast Sodium On Some Biological And Biochemical Aspects, Dna Damage In Drosophila Melanogaster Adults, Ci̇hat Çeli̇k

Turkish Journal of Zoology

Montelukast sodium (MS) is a leukotriene receptor antagonist and used clinically as an antiasthma agent. MS has been hypothesized to have adverse effects in insects. To test this hypothesis, MS was added to the artificial diet of the fruit fly Drosophila melanogaster Meigen (Diptera: Drosophilidae) at different concentrations (1200, 1600, 2000, and 2400 mg/L) under laboratory conditions. The effects of MS on the survival rate and development time of D. melanogaster, as well as its effects on malondialdehyde (MDA) levels and cytochrome P450 monooxygenase (CYP450) enzyme activity in adults were investigated. The genotoxic effect of MS in whole adults was …

Access To Healthy And Nutritious Food In Utah: Results From The 2024 Utah Wellbeing Survey, Heather H. Kelley, Palak Gupta, Courtney G. Flint

All Current Publications

Every Utahn, regardless of income, ZIP code, race, age, or health status, deserves reliable access to affordable, nutritious, and culturally meaningful food. Yet, too many communities across the state face persistent barriers that limit their ability to eat well and live healthy lives. This fact sheet reviews results of a 2024 Utah State University (USU) Extension needs assessment that identified food and nutrition security as a high-priority issue in Utah. It explores the current landscape, identifies key challenges, and outlines strategic opportunities for USU Extension and its partners to enhance food security statewide.

Preserve The Harvest: Canning Goat Meat At Home, Callie Adams, Andrea Schmutz

All Current Publications

Due to its lean composition and nutritional profile similar to those of other tested meats, goat is well-suited for pressure canning. Follow USDA and Utah State University (USU) Extension altitude guidelines. This fact sheet provides guidelines for selecting high-quality meat, using proper equipment, and adhering to tested methods. Home canners can safely preserve goat meat and enjoy its benefits year-round.

Investigating The Mechanisms Of Microbial Interactions Using A Model Cystic Fibrosis Polymicrobial Community, Bassam El Hafi

Dartmouth College Ph.D Dissertations

Cystic fibrosis (CF) airway microbial communities are complex ecosystems where interspecies interactions influence pathogen survival and disease progression. We leverage a CF-relevant in vitro four-species model composed of Pseudomonas aeruginosa, Staphylococcus aureus, Streptococcus sanguinis, and Prevotella melaninogenica, alongside a microbiome dataset with over 4,000 respiratory samples from publicly available sequencing data of CF patient samples, to explore the dynamics of microbial interactions in CF. On a broader scale, we performed microbial network analysis to examine how the latest modulator therapy, elexacaftor/tezacaftor/ivacaftor (ETI), might influence CF microbial communities. Our analysis revealed a reduction in node connections and …

Stiefel Md Anderson Oropharynx Cancer (Mda-Opc) Cohort: A Single-Institution, Prospective Longitudinal Outcomes Study, Amy Moreno, Ariana J Sahli, Faye Johnson, Xiaowen Sun, Carly Barbon, Waree Rinsurongkawong, Wenye Song, Flavie M Luciani, Han Liang, Jun Li, Wei Liu, J Jack Lee, S J Frank, Stephen Lai, Clifton Fuller, Katherine Hutcheson

Faculty, Staff and Student Publications

Purpose: The MD Anderson Oropharynx Cancer (MDA-OPC) cohort is a unique single-institution, prospective longitudinal cancer cohort. The cohort aims to enhance the therapeutic index of OPC management by supporting data needs for independent investigators to conduct rigorous observational studies examining exposures and factors associated with acute and late toxicities, cancer progression, recurrence, new malignancies and quality of life in OPC survivors.

Participants: A total of 1811 patients with OPC with a minimum follow-up of 6 months have been consented to our prospective registry between 18 March 2015 and 29 December 2023. Clinical and treatment (Tx) data are available on all …

Mycobacterium Chelonae Outbreak Investigation At A Quaternary Pediatric Hospital Following The Opening Of A Leed-Certified Critical Care Tower: Where Does Water Sustainability Intersect With Infection Control?, Andrea L Ankrum, Silvia M Caceres, Michael Torsell, Elaine Epperson, Vinicius Calado Nogueira De Moura, Jennifer J Gilick, Michael Strong, Qingyun Liu, Matthew J Strand, Rachel N Wilsey, Jennifer R Honda, Jane E Gross, Felicia A Scaggs-Huang

Faculty, Staff and Student Publications

Objective: Investigate the increased incidence of Mycobacterium chelonae positive respiratory cultures in hospitalized patients.

Design: Apply the Healthcare-Associated Links in Transmission of Nontuberculous Mycobacteria (HALT NTM) toolkit to an outbreak investigation of M. chelonae.

Setting: Quaternary-care pediatric hospital and medical center in the United States with a recently opened LEED-certified critical care tower.

Patients: Adult and pediatric patients with M. chelonae positive respiratory cultures between June 2022 and January 2024.

Methods: An epidemiological investigation involving clinical and laboratory practices, water management, building construction and renovation projects. Environmental sampling of air vents, water sources and endoscope reprocessing equipment was performed. M. …

Forage Mass And Botanical Composition Of Four Annual Forages Grown In A Loblolly Pine Silvopasture In The Mid-South Usa, Christine C. Nieman, Dirk Philipp, Jonathan O.C. Kubesch

Animal Science Faculty Publications and Presentations

Annual forages are commonly planted in open pasture in the Mid-South, but there is little information on the productivity of these forages when incorporated into silvopasture. The objective was to evaluate four annual forages adapted to the Mid-South, namely, arrowleaf clover (Trifolium vesiculosum Savi), crimson clover (Trifolium incarnatum L.), tetraploid annual ryegrass (Lolium multiflorum L.), and diploid annual ryegrass (Lolium multiflorum L.), in a loblolly pine (Pinus taeda L.) silvopasture for seasonal forage mass distribution and annual forage accumulation. The forages were tested in a randomized complete block design with three replicates and three harvests per year: Harvest 1 (H1, …

From Convenience To Consequence The Health Risks Of Eating Ultraprocessed Food, Eve Snyder

Osmosis Magazine

Understanding Ultraprocessed Foods and Their Effects on the Body What happens to the body when it's deprived of vital nutrients from fiber and protein, and pumped full of excessive sugar, fats, and salt? This situation can happen by eating ultraprocessed foods. Ultraprocessed foods are made with processes you wouldn't normally perform in a home kitchen, with ingredients that have little, if any, nutritional value. Pumped with additives to enhance color and taste, ultraprocessed foods may look appealing, but they can have harmful, longterm health risks (Monteiro et al., 2019).

The Impact Of Food Insecurity On The Physical And Mental Health Of Food Service Workers And Their Households, Pedro Andrade

Undergraduate Research Symposium Posters

Food insecurity in the United States continues to be a persistent problem, as this household stressor has worsened in the past decade. The prevalence of food insecurity varies by demographic; however, income is a key factor when discussing food security status. One group experiencing food insecurity, but often overlooked when talking about solutions, is food service workers. This research sought to understand the impact of food insecurity on food service workers and their households. A literature review was conducted to gain a deeper understanding of the associations between food insecurity and physical health, mental health, household health, and occupational and …

Associations Between Gad-7 And Phq-9 Scores And Willingness To Seek Treatment, Josephine Shaw

Undergraduate Research Symposium Posters

In recent years, mental health concerns among college students have increased significantly. This study aims to analyze data on student willingness and frequency to seek counseling services, such as UNLV CAPS (Student Counseling and Psychological Services), and the appeal of utilizing alternative interventions such as exercise and meditation. This study collected data from UNLV students, faculty, and staff through distribution of a scannable QR code. It included whether they were in therapy, the PHQ-9 and GAD-7, their respective functional impairment questions, and willingness to consider therapy alternatives. Based on respondents’ answers to the PHQ-9, the highest proportion peaked at 36% …

Assessing How Early Vs. Late Exercise Influences Whole Body Glucose Tolerance And Insulin Signaling Pathways In Quadriceps During Social Jetlag, Ariana Khzarjyan, Austin Cooper, Paula Martinez, Joshua Corpuz, Srushti Wagh, Elias Malek, Todd Schrubb

Undergraduate Research Symposium Posters

BACKGROUND: Circadian rhythms regulate our physiological and metabolic processes throughout a 24-hour cycle. Disruptions to this rhythm with modern lifestyles creates irregular patterns. One of the most common forms of circadian rhythm disruptions amongst humans happens during the weekends, when people tend to stay up later and sleep in later compared to weekdays. This phenomenon is referred to as social jetlag (SJL).

PURPOSE: To determine whether timed exercise (early vs. late) can reduce the negative effects of social jetlag in mice. More specifically, determining whether exercise conducted in the early or late active phase of mice will impact the effects …

Valorization Of Rice Bran For Functional Bioplastic Fabrication Using Plasma-Activated Water, Saydul Md Safwa, Muhammad Nazrul Islam, Keisha B. Walters, Md Mahfuzur Rahman

Food Science Faculty Publications and Presentations

While plasma has been used for decades for the surface modification of packaging films, in this study, rice bran (RB) and rice bran protein (RBP) films were developed using plasma-activated water (PAW), and the chemical composition, surface structure modifications, surface properties, and thermal properties of these films were characterized. Fourier-transform infrared spectroscopy (FTIR) of the bran and protein films showed that the reactive species in PAW improved hydrogen bonding, as evidenced by the increase in the O-H stretching band at 3300 cm-1 and reduced peak intensity at 2940-2925 cm-1 (C-H stretching), suggesting oxidation of the aliphatic side chains. For the …

The Role Of Nutrition-Sensitive Interventions In Improving Nutritional Outcomes: Findings From A Systematic Review And Meta-Analysis, Thomas De Hoop, Adria Molotsky, Rebecca Walcott, Pablo Gaitán-Rossi, Sonia Hernández-Cordero, Amos Laar, Torben Behmer, Hoa Thi Mai Nguyen, Averi Chakrabarti, Garima Siwach, Varsha Ranjit, Vania Lara-Mejía, Bianca Franco-Lares, Mireya Vilar-Compte

Department of Nutrition and Food Studies Scholarship and Creative Works

Background

Maternal and child undernutrition remains a major global health concern despite modest progress. Accelerating reductions in stunting and wasting will require increased investments in nutrition-sensitive interventions, which target nutrition impacts outside of the healthcare setting. This review examines the effects of four types of nutrition-sensitive interventions —cash/food transfers, nutrition-sensitive agriculture, water/sanitation/hygiene, and school nutrition— on maternal and child nutrition outcomes and dietary diversity.

Methods

We synthesized the evidence using an initial broad search and synthesis for nutrition-sensitive interventions, followed by targeted searches and syntheses for specific interventions and nutrition outcomes. Meta-analyses were performed to evaluate the impacts of cash …

Evaluating Policy And Industry-Based Interventions For Healthier Online Food-Away-From-Home Choices: A Scoping Review, Vincenzina Caputo, Jiayu Sun, Ellen J. Van Loo

Department of Agricultural Economics Faculty Publications

The rapid digital transformation of the food-away-from-home (FAFH) sector has redefined how consumers access and select meals. Digital delivery platforms such as Uber Eats, Deliveroo, and Meituan have become influential market intermediaries, shaping the nutritional landscape of food environments and raising concerns about their healthfulness. This study reviews empirical evidence on policy-based and industry-led interventions aimed at improving dietary outcomes in digital FAFH environments. Following PRISMA guidelines and using machine-learning–assisted screening (ASReview), 37 peer-reviewed studies were identified across four domains: nutritional labeling, fiscal measures, food-assistance programs, and digital nudges or decision-support tools. Findings indicate that although traditional food-policy instruments designed …

Vermicomposting, Hayley Waldbillig, Roslynn Brain, Scott Kent, Roslynn Brain Mccann

All Current Publications

Vermicomposting, or worm composting as it is more commonly known, is the process of using worms to break down discarded food and other organic wastes and convert them into compost and liquid fertilizers.

Can Motivation And Self-Efficacy Predict A Law Enforcement Officer’S General And Job-Specific Fitness?, Robert G. Lockie, Maria M. Beitzel, Tyler Campana, Jennifer Kramer, Robin (Rob) Marc Orr, J. Jay Dawes, Joseph Dulla

International Journal of Exercise Science

International Journal of Exercise Science 18(8): 1393-1409, 2025. https://doi.org/10.70252/GEHB5425 Sedentary behaviors contribute to law enforcement officer fitness declines over a career. An officer’s motivation (desire to exercise) and self-efficacy (belief in ability to exercise) could affect whether they exercise and predict resulting fitness. Data from 60 officers (48 men, 12 women) were analyzed. Motivation (amotivation, external, introjected, identified, integrated, and intrinsic regulation) was measured via the Behavioral Regulation in Exercise Questionnaire. A 6-item questionnaire assessed coping (confidence in exercising under challenging conditions) and scheduling (confidence in scheduling exercise) self-efficacy. General fitness variables included sit-and-reach, grip strength, 60-s push-ups, 60-s sit-ups, …

Effect Of Microbial Inoculation On Phosphate And Nitrogen Uptake From Dry Soil By Two Grasses With Different Nutrient Acquisition Strategies, Reem Hamdan Alkaabi

Thesis/ Dissertation Defenses

Organic matter and other sources of plant nutritional elements typically enter the soil from its surface, resulting in topsoil having the highest microbial activity, concentration of nutritional elements, and rooting densities. In agricultural systems of the UAE, high ambient temperature triggers rapid evaporation and causes the topsoil to dry. Nutrient uptake from dry soil is very challenging for plants, and topsoil dryness can have a negative impact on plant performance.

Beneficial soil microorganisms mediate plant growth by inducing tolerance against abiotic stresses. Arbuscular mycorrhizal (AM) fungi extend a large network of hyphae that helps the plants to acquire water and …

Nutritional Status And Endomycorrhizal Root Colonization Of Various Fruit Tree Species Grown In The Open Field In Al Ain, Uae, Mariam Mohammed Alhebsi

Thesis/ Dissertation Defenses

Domestic cultivation of fruits can greatly contribute to food security and supply of residents with healthy but highly perishable products. However, in the area of Al Ain, the cultivation of dicotyledonous fruit trees at the commercial scale is relatively uncommon, due to risks associated with the impact of the harsh environmental conditions on plant performance. The present study aimed at investigating to which extent mineral nutrient deficiency is responsible for the poor performance of fruit trees during the warm summer season. A five year old fruit tree plantation at the UAEU Research Farm in Al Foah served as study site. …

The Role Of Inflammatory Cytokines In The Bidirectional Relationship Between Periodontitis And Diabetes Mellitus, Andrew R. Witty

Oral Health

Periodontitis and type 2 diabetes mellitus are associated with each other in a bidirectional relationship. The mechanism by which diabetes affects periodontitis is understood to be due to the inflammatory effects of hyperglycemia (high blood glucose levels) and a hospitable environment for sugar-consuming bacteria. Periodontitis is known to be associated with higher levels of glycated hemoglobin (HbA_1c), a long-term measurement of blood glucose control, and treatment of periodontitis reduces HbA_1c. Inflammation caused by periodontitis induces insulin resistance (which leads to higher blood glucose levels), but due to the complex nature of inflammation it is difficult to …

Advanced Plant Growth Using Halloysite Nanotubes (Hnts) And Waste Extraction For Medical Applications, Zeinab Jabbari Velisdeh

Doctoral Dissertations

This dissertation presents an integrated research framework that bridges nanotechnology, green chemistry, and sustainable agriculture, aiming to address two critical global challenges: enhancing plant growth under resource-limited conditions and valorizing agricultural waste for bioactive compound extraction. The study is divided into three major projects that together highlight the innovative application of magnesium oxide-coated halloysite nanotubes (MgO-HNTs) and the development of environmentally conscious extraction methods for high-value phytochemicals. The first component of this work investigates the design, fabrication, and functional evaluation of MgO-HNTs as advanced nanocarriers for promoting seed germination and early root development in tomato plants. MgO-HNTs were synthesized via …