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Evaluating The Performance Of Broccoli (Brassica Oleracea Var. Italica) In The Sandponics System Using Brackish Water With Biochar And Compost, Gabriel Oyebode
Evaluating The Performance Of Broccoli (Brassica Oleracea Var. Italica) In The Sandponics System Using Brackish Water With Biochar And Compost, Gabriel Oyebode
Theses and Dissertations
Some of the most pronounced effects of climate change on agricultural output include the depletion of freshwater resources and heightened salinization of arable land, especially in arid and semi-arid regions, adversely affecting crop yields. Many economic vegetable crops including members of the brassica family are sensitive to salt-stress. The use of organic soil amendments such as biochar and compost as complimentary nutrient sources in the sandponics system can improve the performance of crops. The study aimed to evaluate the effect of organic amendment on the growth performance and yield of broccoli and Nile tilapia (Oreochromis niloticus) under brackish …
Excavations On The Southwestern Margins Of Giv‘Ati Parking Lot, Jerusalem: Markers Of Byzantine–Early Islamic Transition (Pp. 303–338), Yana Tchekhanovets
Excavations On The Southwestern Margins Of Giv‘Ati Parking Lot, Jerusalem: Markers Of Byzantine–Early Islamic Transition (Pp. 303–338), Yana Tchekhanovets
'Atiqot
The small-scale excavation on the southwestern margins of Giv‘ati Parking Lot exposed important findings dating to the transition between the Byzantine and Early Islamic periods. A flagstone-paved street dating from the Byzantine period was exposed, representing one of the major thoroughfares of Jerusalem that served an important pilgrimage route. This street ceased to exist at the beginning of the Early Islamic period when the function of the area changed from residential to industrial. The remains of a small-scale metallurgical workshop, including numerous copper alloy fragments, metal slags, pottery crucible fragments and large amounts of ash, were dated to the Umayyad …
“Jerusalem Ivories”: Iron Age Decorated Ivory Panels From Building 100, Giv‘Ati Parking Lot Excavations, And Their Cultural Setting (Pp. 57–74), Reli Avisar, Yiftah Shalev, Harel Shochat, Yuval Gadot, Ido Koch
“Jerusalem Ivories”: Iron Age Decorated Ivory Panels From Building 100, Giv‘Ati Parking Lot Excavations, And Their Cultural Setting (Pp. 57–74), Reli Avisar, Yiftah Shalev, Harel Shochat, Yuval Gadot, Ido Koch
'Atiqot
This preliminary report presents an assemblage of ivory items found in the precincts of the City of David National Park in Jerusalem. Such prestigious ivory items have only been found in prominent cities, such as Late Bronze Age Megiddo and Iron Age Samaria, where they originated in buildings recognized as part of palatial complexes. These items are the first of their kind to be found in Jerusalem, revealing the wealth of Jerusalem’s elite on the eve of the city’s destruction in 586 BCE. The findings shed light on the cultural and economic role of the city’s elite in the “global” …
Pottery And Small Finds From Burial Cave 900 In Naḥal Refa’Im, Jerusalem (Pp. 33–67), Lilly Gershuny
Pottery And Small Finds From Burial Cave 900 In Naḥal Refa’Im, Jerusalem (Pp. 33–67), Lilly Gershuny
'Atiqot
A total of 107 pottery vessels were discovered in the cave, dating from the Intermediate Bronze Age and Middle Bronze Age II. The Intermediate Bronze Age assemblage was found in situ and as such, is an important contribution to the study of this period in greater Jerusalem. The finds from this period include jars, a four-spouted lamp and a stopper. The MB II pottery includes piriform juglets, globular bowls, jugs, store jars and dipper juglets. Three unique specimens were found: an unusually decorated Tell el-Yahudiyeh juglet; a ring flask—the earliest of its kind in Canaan; and an intact bull-shaped rython. …
The Role Of Biofilm Matrix On The Growth, Survival, And Diagnosis In Enterobacteriaceae, Kavi Bharathi R
The Role Of Biofilm Matrix On The Growth, Survival, And Diagnosis In Enterobacteriaceae, Kavi Bharathi R
Theses and Dissertations
Bacteria in nature live together encased in a matrix creating community ecosystems called biofilms, this structured space protects them from hostile environments. This study aimed to understand the role of the biofilm matrix in the growth and survival of Enterobacteriaceae. Our hypothesis proposes that subgroups of individuals within a biofilm can specialize in the production of different matrix components.
Matrix expression is metabolically costly, despite its unicellular simplicity, microbes can coordinate complex behaviour like sharing of matrix between producers and non-producers as an adept evolutionary strategy. Their resilience to stress during biofilm formation was studied to assess their abilities to …
Online Media Sentiment Analysis Of Shrimp And Salmon In The United States, Jingjing Tao, Kwamena K. Quagrainie
Online Media Sentiment Analysis Of Shrimp And Salmon In The United States, Jingjing Tao, Kwamena K. Quagrainie
Department of Agricultural Economics Faculty Publications
There is a growing interest in the U.S. seafood and aquaculture market; however, studies utilizing online information to understand this market are limited. This study employs online media analytics to obtain insights into consumer perceptions and potential demand signals for shrimp and salmon in the U.S. Our results show that platform X is the preferred medium for shrimp and salmon discussions, with shrimp's physical quality and salmon's environmental impact being the two major perception drivers. Additionally, autoregressive modeling is conducted to explore the dynamics of net sentiments. Farmed shrimp and salmon consistently exhibit lower net sentiments compared to their wild …
Plasmids Encode And Can Mobilize Onion Pathogenicity In Pantoea Agglomerans, Gi Yoon Shin, Jo Ann Asselin, Amy Smith, Brenna Aegerter, Teresa Coutinho, Mei Zhao, Bhabesh Dutta, Jennie Mazzone, Ram Neupane, Beth Gugino, Christy Hoepting, Manzeal Khanal, Subas Malla, Claudia Nischwitz, Jaspreet Sidhu, Antoinette Machado Burke, Jane Davey, Mark Uchanski, Michael L. Derie, Lindsey J. Du Toit, Stephen Stresow-Cortez, Jean M. Bonasera, Paul Stodghill, Brian Kvitko
Plasmids Encode And Can Mobilize Onion Pathogenicity In Pantoea Agglomerans, Gi Yoon Shin, Jo Ann Asselin, Amy Smith, Brenna Aegerter, Teresa Coutinho, Mei Zhao, Bhabesh Dutta, Jennie Mazzone, Ram Neupane, Beth Gugino, Christy Hoepting, Manzeal Khanal, Subas Malla, Claudia Nischwitz, Jaspreet Sidhu, Antoinette Machado Burke, Jane Davey, Mark Uchanski, Michael L. Derie, Lindsey J. Du Toit, Stephen Stresow-Cortez, Jean M. Bonasera, Paul Stodghill, Brian Kvitko
Biology Faculty Publications
Pantoea agglomerans is one of four Pantoea species reported in the USA to cause bacterial rot of onion bulbs. However, not all P. agglomerans strains are pathogenic to onion. We characterized onion-associated strains of P. agglomerans to elucidate the genetic and genomic signatures of onion-pathogenic P. agglomerans. We collected > 300 P. agglomerans strains associated with symptomatic onion plants and bulbs from public culture collections, research laboratories, and a multi-year survey in 11 states in the USA. Combining the 87 genome assemblies with 100 high-quality, public P. agglomerans genome assemblies we identified two well-supported P. agglomerans phylogroups. Strains causing severe …
Spatiotemporal Variability And Functional Redundancy Obscure Effects Of Urbanization On Strawberry Pollinators, Kyla D. Schulte, Caleb J. Wilson, Anna Tawril, Mary A. Jamieson
Spatiotemporal Variability And Functional Redundancy Obscure Effects Of Urbanization On Strawberry Pollinators, Kyla D. Schulte, Caleb J. Wilson, Anna Tawril, Mary A. Jamieson
Entomology Faculty Publications
Pollination services across rural–urban gradients may vary as land cover and other environmental attributes differentially influence pollinators. Most studies examining crop pollination, however, have been conducted in rural environments, while research in urban areas has lagged behind despite growing interest in urban agriculture. In this study, we hypothesized that increased urbanization would alter pollinator community composition due to a reduction in natural areas within the surrounding landscape, potentially decreasing pollinator abundance. To evaluate this hypothesis, we conducted a three-year study using strawberries as a focal study crop. We characterized the abundance, diversity, and community composition of bees across 10 farms …
Ai-Integrated Cross-Disciplinary Liberal Arts Colloquium, Diana S. Perdue, Niloofar Gholamrezaei, Jennifer Krusinger, Shannon Hogan
Ai-Integrated Cross-Disciplinary Liberal Arts Colloquium, Diana S. Perdue, Niloofar Gholamrezaei, Jennifer Krusinger, Shannon Hogan
Teaching Repository of AI-Infused Learning
What began organically as an AI-focused collaboration between faculty in different disciplines along with researchers in the college’s Center for Instructional Innovation, has evolved into college-wide pedagogical workshops and the development of a studio model that affects courses, programs, and paradigms for faculty scholarship.
Lessons from these collaborations inform understandings of how key features of liberal arts education can be supported through intentional AI-integration within a Cross-Disciplinary Liberal Arts Colloquium. More specifically, this colloquium offers recommendations on adapting a collaborative, interdisciplinary, and reflective studio model to in-person, online, and hybrid educational environments facilitated through a Technological Pedagogical Content Knowledge (TPACK) …
Humination Modification: A Green Approach To Improve The Material Properties Of Scots Pine (Pinus Sylvestris L.) Sapwood, Amir Ghavidel, Arantxa Eceiza, Xinfeng Xie, Reza Hosseinpourpia
Humination Modification: A Green Approach To Improve The Material Properties Of Scots Pine (Pinus Sylvestris L.) Sapwood, Amir Ghavidel, Arantxa Eceiza, Xinfeng Xie, Reza Hosseinpourpia
Michigan Tech Publications
Recently, wood modification with environmentally friendly modification agents has received special attention. To this end, this study was conducted to use humin fractions, in combination with citric acid (CA) and succinic acid (SA), as reaction catalysts for the modification of Scots pine (Pinus sylvestris L.) sapwood. The effects of humination modification were evaluated by means of dimensional stability, static and dynamic mechanical properties, thermal stability, crystalline structure, and biological durability tests on modified samples and compared with the unmodified reference ones. According to the results, the dimensional stability of the huminated samples significantly increased, and this increase with the presence …
Trmt1l-Catalyzed M22g27 On Tyrosine Trna Is Required For Efficient Mrna Translation And Cell Survival Under Oxidative Stress, Sseu-Pei Hwang, Han Liao, Katherine Barondeau, Xinyi Han, Cassandra Herbert, Amirtha Shekar, Patrick A Limbach, Jeffrey T Chang, Catherine Denicourt
Trmt1l-Catalyzed M22g27 On Tyrosine Trna Is Required For Efficient Mrna Translation And Cell Survival Under Oxidative Stress, Sseu-Pei Hwang, Han Liao, Katherine Barondeau, Xinyi Han, Cassandra Herbert, Amirtha Shekar, Patrick A Limbach, Jeffrey T Chang, Catherine Denicourt
Faculty, Staff and Student Publications
tRNA modifications are critical for several aspects of their functions, including decoding, folding, and stability. Using a multifaceted approach encompassing eCLIP-seq and nanopore tRNA-seq, we show that the human tRNA methyltransferase TRMT1L interacts with the component of the Rix1 ribosome biogenesis complex and binds to the 28S rRNA as well as to a subset of tRNAs. Mechanistically, we demonstrate that TRMT1L is responsible for catalyzing N2,N2-dimethylguanosine (m22G) solely at position 27 of tRNA-Tyr-GUA. Surprisingly, TRMT1L depletion also impaired the deposition of 3-(3-amino-3-carboxypropyl) uridine (acp3U) and dihydrouridine on tRNA-Tyr-GUA, Cys-GCA, and Ala-CGC. TRMT1L knockout cells have a marked decrease in tRNA-Tyr-GUA …
Challenges And Opportunities In The Dissemination Of Scientific Content: Insights From Media Professionals In Jordan, Ruba Mustafa Mohammad, Mahmoud Ahmad Al-Rajabi, Hala Nabil Amr
Challenges And Opportunities In The Dissemination Of Scientific Content: Insights From Media Professionals In Jordan, Ruba Mustafa Mohammad, Mahmoud Ahmad Al-Rajabi, Hala Nabil Amr
This study explored the challenges and opportunities in disseminating scientific content from the perspective of media experts in Jordan. Using a descriptive methodology and a questionnaire, the research aimed to understand the landscape better. The sample included 343 media experts holding master's degrees or higher in various media fields, along with several journalists actively working in the sector. The study revealed several key findings. Chief among them are the numerous obstacles hindering the dissemination of scientific content in Jordanian media. These include a lack of training for journalists on accessing new scientific information, a general absence of critical thinking skills …
The Degree Of Dependence Of The Jordanian Public On Social Media In Health Awareness Of Obesity Diseases (Survey Study), Jumana Irshiedat, Kamel Khurshid Murad
The Degree Of Dependence Of The Jordanian Public On Social Media In Health Awareness Of Obesity Diseases (Survey Study), Jumana Irshiedat, Kamel Khurshid Murad
The article aimed to reveal the dependency of social media platforms in educating the Jordanian public about obesity diseases and explore the cognitive, emotional, and behavioral effects on the Jordanian public. The survey method was adopted; an approach used in descriptive studies, and the questionnaire tool was used to a sample (357) of the Jordanian public in Amman. The study-produced results including the platform most used by the Jordanian public to receive knowledge about health awareness is WhatsApp in the first place, followed by Instagram and then Facebook. The results also showed that the health topics of most interest to …
The Energy Transition In The Jordanian Media, Hanan Al-Shiekh
The Energy Transition In The Jordanian Media, Hanan Al-Shiekh
The study aimed to clarify the role of scientific journalism towards stimulating investment in environmentally friendly renewable energy sources, which is one of the necessary challenges facing the Kingdom of Jordan for economic growth and social development, due to its heavy dependence on energy imports, which reflects negatively on the Jordanian economy. This study is one of the descriptive studies that focuses on describing a specific topic, as it is in the current reality, in terms of its general and detailed characteristics, including variables, elements, relationships, and influences, which are among the most prominent features of scientific journalism in terms …
The Role Of Television In Increasing Knowledge About Health Issues Among Jordanian Citizens, Izzat Mohammad Hijab, Ahmad Oreqat, Hani Al-Badri
The Role Of Television In Increasing Knowledge About Health Issues Among Jordanian Citizens, Izzat Mohammad Hijab, Ahmad Oreqat, Hani Al-Badri
This study explores the role of TV health programs in increasing the knowledge of Jordanian citizens about health issues. The study was based on the social survey methodology through a questionnaire distributed to a sample of 200 people from the city of Amman watching Jordan Television (JTV) health programs. The researcher concluded the following; a high watching for health programs, and that the Jordanians watch health programs with their family at home. The study also confirmed that the Jordanian benefits from health programs provided by JTV, and these programs are important and essential in educating citizens in health issues. Finally, …
Sigma1 Inhibitor Suppression Of Adaptive Immune Resistance Mechanisms Mediated By Cancer Cell Derived Extracellular Vesicles, Paola A. Castagnino, Derick A. Haas, Luca Musante, Nathalia A. Tancler, Bach V. Tran, Rhonda Kean, Alexandra R. Steck, Luis A. Martinez, Elahe A. Mostaghel, D. Craig Hooper, Felix J. Kim
Sigma1 Inhibitor Suppression Of Adaptive Immune Resistance Mechanisms Mediated By Cancer Cell Derived Extracellular Vesicles, Paola A. Castagnino, Derick A. Haas, Luca Musante, Nathalia A. Tancler, Bach V. Tran, Rhonda Kean, Alexandra R. Steck, Luis A. Martinez, Elahe A. Mostaghel, D. Craig Hooper, Felix J. Kim
Department of Pharmacology, Physiology, and Cancer Biology Faculty Papers
Adaptive immune resistance in cancer describes the various mechanisms by which tumors adapt to evade anti-tumor immune responses. IFN-γ induction of programmed death-ligand 1 (PD-L1) was the first defined and validated adaptive immune resistance mechanism. The endoplasmic reticulum (ER) is central to adaptive immune resistance as immune modulatory secreted and integral membrane proteins are dependent on ER. Sigma1 is a unique ligand-regulated integral membrane scaffolding protein enriched in the ER of cancer cells. PD-L1 is an integral membrane glycoprotein that is translated into the ER and processed through the cellular secretory pathway. At the cell surface, PD-L1 is an immune …
Testing As Teaching: A Model For Fitness Assessment Practice And Service-Learning In Exercise Physiology Laboratory Education, Marc Apkarian
Testing As Teaching: A Model For Fitness Assessment Practice And Service-Learning In Exercise Physiology Laboratory Education, Marc Apkarian
Educational Practices in Kinesiology
This resource is intended to provide a model for fitness assessment practice to promote student learning in an undergraduate exercise physiology laboratory course. The goal is for students to gain practical experience in fitness assessment procedures, both through skills practice and service-learning opportunities. The inclusion of an assignment requiring a specified number of assessments to be completed within the term requires additional student practice opportunities. Instruction, demonstration, and initial practice of tests associated with health-related physical fitness components must occur early in the course, so as to permit sufficient opportunities, in class or outside of class, over the remainder of …
An Evaluation Of Sports Nutrition Knowledge And Influencing Factors In Ncaa Division Iii Athletes, Kerrie Berends, Michael J. Wierenga, Madeline Frens
An Evaluation Of Sports Nutrition Knowledge And Influencing Factors In Ncaa Division Iii Athletes, Kerrie Berends, Michael J. Wierenga, Madeline Frens
University Faculty Publications and Creative Works
Introduction:This study evaluated the sports nutrition knowledge of NCAA Division III (DIII) athletes, examining the influence of demographic and sport-specific factors. Nutrition is a critical component of athletic performance, recovery, and overall health, yet prior research indicatescollegiate athletes often lack adequate nutrition knowledge.
Methods: A total of 412 athletes, representing 17 different sports across endurance, power, and skill categories, completed the validated Abridged Nutrition for Sport Knowledge Questionnaire (A-NSKQ). The sample included freshmen through fifth-year seniorathletes, predominantlyCaucasian (85%).
Results: The average A-NSKQ score was 17.1 out of 35 (48.9%), indicating suboptimal knowledge. Significant differences were found across …
Using Rna-Sequencing To Explore Mechanistic Markers, New Therapeutics, And Immune Imbalance: A Study Of Cancer And Autoimmunity Through The Lens Of Triple Negative Breast Cancer, Systemic Lupus Erythematosus, And B-Cell Non-Hodgkin's Lymphoma, Naomi Lydia Rapier-Sharman
Using Rna-Sequencing To Explore Mechanistic Markers, New Therapeutics, And Immune Imbalance: A Study Of Cancer And Autoimmunity Through The Lens Of Triple Negative Breast Cancer, Systemic Lupus Erythematosus, And B-Cell Non-Hodgkin's Lymphoma, Naomi Lydia Rapier-Sharman
Theses and Dissertations
Cancer and autoimmune diseases both impose a substantial healthcare burden on the US and world populations. In 2016, there were over 17 million cases of cancer, leading to nearly nine million deaths. Additionally, autoimmune diseases cause substantial mortality and morbidity and are present in 3-5% of the general population. Despite the increased attention scientists now give diseases that are impacted by immune imbalance, we have yet to find regimens to treat the core cause(s) of tissue dysfunction without drastically decreasing the quality of life for many patients with either cancer or autoimmune disease. For instance, anti-CD19 Chimeric Antigen Receptor (CAR) …
What Women Intercollegiate Coaches Say: Decision-Making Factors When Navigating Career Choices, Courtney Boucher, Nicole M. Lavoi
What Women Intercollegiate Coaches Say: Decision-Making Factors When Navigating Career Choices, Courtney Boucher, Nicole M. Lavoi
International Journal of Physical Activity and Health
To address misconceptions about the lack of women in sport coaching, factors influencing intercollegiate women coaches' career decisions, including their choices to leave positions, apply for new ones, and accept or deny job offers were explored. Utilizing a multi-level analysis underpinned by critical feminist theory, a comprehensive understanding of the systemic and structural barriers women coaches faced, as well as the strategies they employed to navigate their careers were illuminated. Key findings revealed that unequal pay, lack of administrative support, insufficient resources, and pervasive gender biases significantly impacted women's career choices. The importance of supportive workplace environments, flexible working conditions, …
The Caitlin Clark Effect: Illuminating Women’S Sport History, Shelley Lucas
The Caitlin Clark Effect: Illuminating Women’S Sport History, Shelley Lucas
International Journal of Physical Activity and Health
The Caitlin Clark Effect is a term that describes the impact of the University of Iowa basketball player on the popularity of women’s basketball, which occurred in conjunction with Clark’s record-breaking performances in 2023 and 2024, as well as the Iowa team’s successes in the NCAA championship tournament. While the Caitlin Clark Effect is associated with intense media attention, ticket sales, and viewership, it also illuminates significant and lesser-known aspects of women’s sport history, specifically media coverage, the Association of Intercollegiate Athletics for Women (AIAW), and the state of Iowa’s unique basketball heritage and ‘6-on-6’ basketball rules. The purpose of …
A Unique Metal Object From Tiberias (Pp. 173–181), Myriam Rosen-Ayalon
A Unique Metal Object From Tiberias (Pp. 173–181), Myriam Rosen-Ayalon
'Atiqot
An uncommon metal artifact (a stand?) was uncovered in the course of public works in Tiberias. The object is an open cylinder, made of sheet-metal, perhaps bronze. Both the outer and inner surfaces are adorned with a band of painted decoration: the exterior surface depicts a scene of human figures, while the interior one is a beautiful inscription in kufic script. No parallels to Islamic painted metalwork have been yet discovered; however, our painted object should perhaps be seen within the wider context of the art of painting under the Fatimids.
Late Roman Funerary Customs In Light Of The Grave Goods From The Cemetery On Sallah Ed-Din Street, Jerusalem (Pp. 81–123), Tamar Winter
Late Roman Funerary Customs In Light Of The Grave Goods From The Cemetery On Sallah Ed-Din Street, Jerusalem (Pp. 81–123), Tamar Winter
'Atiqot
The burial ground on Sallah ed-Din Street yielded many glass vessels and numerous gold, lead, copper/bronze, iron, glass, wood, shell and bone artifacts. The glass vessels and the various artifacts from the cemetery resemble finds from other Late Roman burials in Jerusalem and its vicinity. It can be inferred that some of the interred in the cemetery on Sallah ed-Din Street were foreigners, perhaps soldiers in the Roman army and their families.
“The Lord Will Roar From Zion” (Amos 1:2): The Lion As A Divine Attribute On A Jerusalem Seal And Other Hebrew Glyptic Finds From The Western Wall Plaza Excavations (Pp. 1*–13*), Tallay Ornan, Shlomit Weksler-Bdolah, Shua Kisilevitz, Benjamin Sass
“The Lord Will Roar From Zion” (Amos 1:2): The Lion As A Divine Attribute On A Jerusalem Seal And Other Hebrew Glyptic Finds From The Western Wall Plaza Excavations (Pp. 1*–13*), Tallay Ornan, Shlomit Weksler-Bdolah, Shua Kisilevitz, Benjamin Sass
'Atiqot
A stamp seal bearing the image of a roaring lion and a Hebrew legend was found during the excavations of the Western Wall Plaza, Jerusalem. It is the first seal with a lion motif to be published from Iron Age II Jerusalem, and one of only a few from Judah bearing a lion motif. Two other glyptic finds include a fragment of a scaraboid, inscribed in Hebrew, and a bulla, with a palmette and traces of a Hebrew inscription. These finds are an important addition to the growing corpus of both inscribed and uninscribed seals that have been unearthed in …
Member In The Entourage Of Yahweh: A Uraeus Seal From The Western Wall Plaza Excavations, Jerusalem (Pp. 15*–20*), Tallay Ornan
Member In The Entourage Of Yahweh: A Uraeus Seal From The Western Wall Plaza Excavations, Jerusalem (Pp. 15*–20*), Tallay Ornan
'Atiqot
A seal engraved with a four-winged uraeus was discovered in the area near the Iron Age four-room house in the Western Wall Plaza excavations, Jerusalem. The rendering is schematic, emphasizing the unsophisticated workmanship of the seal. This seal joins quite a few similar late eighth- or seventh-century BCE representations from Judah, hinting at an association of the four-winged uraeus with Yahwistic symbolism.
Inhibition Of Vascular Smooth Muscle Cell Perk/Atf4 Er Stress Signaling Protects Against Abdominal Aortic Aneurysms, Brennan Callow, Xiaobing He, Nicholas Juriga, Kevin D Mangum, Amrita Joshi, Andrea Obi, Dianna M Milewicz, Mary X O'Riordan, Johann Gudjonsson, Katherine Gallagher, Frank M Davis
Inhibition Of Vascular Smooth Muscle Cell Perk/Atf4 Er Stress Signaling Protects Against Abdominal Aortic Aneurysms, Brennan Callow, Xiaobing He, Nicholas Juriga, Kevin D Mangum, Amrita Joshi, Andrea Obi, Dianna M Milewicz, Mary X O'Riordan, Johann Gudjonsson, Katherine Gallagher, Frank M Davis
Faculty, Staff and Student Publications
Abdominal aortic aneurysms (AAA) are a life-threatening cardiovascular disease for which there is a lack of effective therapy preventing aortic rupture. During AAA formation, pathological vascular remodeling is driven by vascular smooth muscle cell (VSMC) dysfunction and apoptosis, for which the mechanisms regulating loss of VSMCs within the aortic wall remain poorly defined. Using single-cell RNA-Seq of human AAA tissues, we identified increased activation of the endoplasmic reticulum stress response pathway, PERK/eIF2α/ATF4, in aortic VSMCs resulting in upregulation of an apoptotic cellular response. Mechanistically, we reported that aberrant TNF-α activity within the aortic wall induces VSMC ATF4 activation through the …
Mitochondrial Mrna And The Small Subunit Rrna In Budding Yeasts Undergo 3'-End Processing At Conserved Species-Specific Elements, Michael Anikin, Michael F Henry, Viktoria Hodorova, Hristo B Houbaviy, Jozef Nosek, Dimitri G Pestov, Dmitriy A Markov
Mitochondrial Mrna And The Small Subunit Rrna In Budding Yeasts Undergo 3'-End Processing At Conserved Species-Specific Elements, Michael Anikin, Michael F Henry, Viktoria Hodorova, Hristo B Houbaviy, Jozef Nosek, Dimitri G Pestov, Dmitriy A Markov
Rowan-Virtua School of Osteopathic Medicine Departmental Research
Respiration in eukaryotes depends on mitochondrial protein synthesis, which is performed by organelle-specific ribosomes translating organelle-encoded mRNAs. Although RNA maturation and stability are central events controlling mitochondrial gene expression, many of the molecular details in this pathway remain elusive. These include
Optimized Methods To Quantify Tumor Treating Fields (Ttfields)-Induced Permeabilization Of Glioblastoma Cell Membranes, Melisa Martinez-Paniagua, Sabbir Khan, Nikita W Henning, Sri Vaishnavi Konagalla, Chirag B Patel
Optimized Methods To Quantify Tumor Treating Fields (Ttfields)-Induced Permeabilization Of Glioblastoma Cell Membranes, Melisa Martinez-Paniagua, Sabbir Khan, Nikita W Henning, Sri Vaishnavi Konagalla, Chirag B Patel
Faculty, Staff and Student Publications
Glioblastoma (GBM) is a lethal primary brain cancer with a 5.6% five-year survival rate. Tumor treating fields (TTFields) are alternating low-intensity electric fields that have demonstrated a GBM patient survival benefit. We previously reported that 0.5-24 h of TTFields exposure resulted in an increased uptake of FITC-dextran fluorescent probes (4-20 kDa) in human GBM cells. However, this approach, in which a fluorescence plate-based detector is used to evaluate cells attached to glass coverslips, cannot distinguish FITC-dextran uptake in live vs. dead cells. The goal of the study was to report the optimization and validation of two independent methods to quantify …
Failure Of The Farm Bill Process In 2023—A Perspective From Social Media Activity, Roman Keeney, Nicole Olynk Widmar, Austin Berenda
Failure Of The Farm Bill Process In 2023—A Perspective From Social Media Activity, Roman Keeney, Nicole Olynk Widmar, Austin Berenda
Department of Agricultural Economics Faculty Publications
In September 2023, the current farm bill was allowed to expire. This marked the fourth consecutive farm bill to see its authorization lapse before replacement legislation was signed into law. The failure in 2023 is notable as significant trade and covid shocks revealed needed reforms in farm and food safety nets. We develop a unique online and social media dataset and metrics to examine 2023 online activity to understand drivers of online farm bill discussion and implications for the future of the traditional farm bill political coalition. These findings echo the increasing concern about future farm bills amid a broadening …
Conservation Of The Ancient Boat From The Sea Of Galilee, Orna Cohen
Conservation Of The Ancient Boat From The Sea Of Galilee, Orna Cohen
'Atiqot
The Galilee or Kinneret Boat, also dubbed “Jesus’ Boat,” was found and excavated in 1986. The various degrees of deterioration of the wood, the wood species and the size of the vessel were factors that reflected on the choice of the conservation method. Iron elements, such as nails, were also treated, and biological and bacterial problems were addressed. This report describes the chemical process of the conservation treatment of the wood and iron nails; the overcoming of biological and bacterial problems; and additional technical aspects of the conservation process. The report also describes the stages of preparation of the boat …