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Full-Text Articles in Entire DC Network
Machine Learning Integrated Designing And Screening Of 8-Hydroxyquinoline Based Metallo-Beta-Lactamase Inhibitors, Anthony M. Baudino, Kari Stone
Machine Learning Integrated Designing And Screening Of 8-Hydroxyquinoline Based Metallo-Beta-Lactamase Inhibitors, Anthony M. Baudino, Kari Stone
Chemistry Department Faculty Articles
The rapid emergence of metallo-b-lactamase-mediated antibiotic resistance has created an urgent need for new inhibitor discovery strategies. In this work, a machine-learning-guided workflow was developed to generate and prioritize potential inhibitors targeting NDM-1. A SMILES-based variational autoencoder was first pretrained on a broad molecular dataset to learn general chemical syntax and latent molecular representations. The model was then fine-tuned on an 8-hydroxyquinoline-enriched dataset to bias molecular generation toward zinc-binding chemical space relevant to metallo-β-lactamase inhibition. Generated compounds were processed through structural filtering and docking-based evaluation to create training data for downstream predictive modeling. Molecular fingerprints and physicochemical descriptors were then …
Systematic Review Of The Institutionalization Of Service Learning In Higher Education, Wilmer Hernan Cruz Gutierrez
Systematic Review Of The Institutionalization Of Service Learning In Higher Education, Wilmer Hernan Cruz Gutierrez
ASEAN Journal of Community Engagement
An increasing number of universities are integrating service-learning (SL) to fulfill their social mission. However, sustainable institutionalization of SL remains a persistent challenge. This study identifies and analyzes the factors, actors, and strategies that drive and inhibit SL institutionalization in higher education. Using the PRISMA 2020 guidelines, a systematic literature review analyzed 52 documents from seven academic databases (including WoS, Scopus, and ERIC). The findings were grouped into three sections: cultural (integration into institutional values/missions), process (articulation within teaching, research, and outreach), and structural dimensions (dedicated support entities). The results obtained reveal a reciprocal relationship where cultural alignment enables processual …
Land Conversion, Food Security, And Deforestation In Indonesia: Evidence From Farmer-Level Decisions, Mohammad Rondhi, Rizky Yanuarti, Anik Suwandari, Joni Murti Mulyo Aji, Rokhani Rokhani, Ebban Bagus Kuntadi, Subhan Arif Budiman, Yasuhiro Mori, Takumi Kondo, Orawan Srisompun
Land Conversion, Food Security, And Deforestation In Indonesia: Evidence From Farmer-Level Decisions, Mohammad Rondhi, Rizky Yanuarti, Anik Suwandari, Joni Murti Mulyo Aji, Rokhani Rokhani, Ebban Bagus Kuntadi, Subhan Arif Budiman, Yasuhiro Mori, Takumi Kondo, Orawan Srisompun
Journal of Environmental Science and Sustainable Development
Agricultural land conversion (ALC) creates a dual sustainability challenge: the loss of productive farmland to urban expansion and the conversion of forested land into new agricultural areas. Farmland loss may reduce food production capacity, while forest conversion for agriculture may increase environmental degradation. These facts create a structural policy dilemma for Indonesia: safeguarding food security while simultaneously preventing deforestation. This study examines the patterns and drivers of land conversion in Indonesia over the past decade, with a focus on its implications for food security and deforestation. Using Indonesian Farmers Income Survey (Survei Pendapatan Petani, SPP) from 2004 (n …
Governance, Culture, And Law: The Expanding Scope Of Environmental Science And Sustainable Development Research, Ahyaudin Sodri, Herdis Herdiansyah
Governance, Culture, And Law: The Expanding Scope Of Environmental Science And Sustainable Development Research, Ahyaudin Sodri, Herdis Herdiansyah
Journal of Environmental Science and Sustainable Development
Environmental science emerged as a discipline based on physical measurements, such as soil pollutant levels (Ailijiang et al., 2022), ecological restoration (Yue et al., 2026), city surface temperature (Shafizadeh-Moghadam et al., 2025), and microbial density in air samples (Hayleeyesus & Manaye, 2014). However, its objects of study increasingly extend beyond the confines of the laboratory. Questions that were once sufficiently answered with measurement data now require answers through draft laws, Constitutional Court decisions, financial reports of mining companies, and even traditional ritual discourses governing community access to forests. In other words, environmental …
Effects Of Scion And Rootstock On Arbuscular Mycorrhizal Symbiosis And Spore Communities In Vitis Vinifera, Nicholas Vergara, Stephen Bentivenga
Effects Of Scion And Rootstock On Arbuscular Mycorrhizal Symbiosis And Spore Communities In Vitis Vinifera, Nicholas Vergara, Stephen Bentivenga
STEM Student Research Symposium Posters
Arbuscular mycorrhizal fungi (AMF) are obligate root symbionts that extend host nutrient uptake in exchange for photosynthate. Nearly all commercial wine grapes (Vitis vinifera) are grafted onto American rootstocks selected for phylloxera resistance, drought tolerance, and vigor, meaning the root system interfacing with soil fungi is genetically distinct from the fruiting scion. Whether root system origin shapes AMF association remains poorly resolved, particularly in sandy, low-fertility soils. We compared AMF colonization and spore communities across four rootstock–scion combinations (Cabernet Franc and Merlot scions, own-rooted and riparian rootstock) at William Heritage® Winery in Mullica Hill, NJ. Fine roots were cleared, stained, …
Comparison Of Arbuscular Mycorrhizal Fungal Colonization And Spore Communities Between Clover-Dominated Cover Crop And Restored Native Grass Systems, Nicholas Vergara, Stephen Bentivenga
Comparison Of Arbuscular Mycorrhizal Fungal Colonization And Spore Communities Between Clover-Dominated Cover Crop And Restored Native Grass Systems, Nicholas Vergara, Stephen Bentivenga
STEM Student Research Symposium Posters
Arbuscular mycorrhizal fungi (AMF) are obligate root symbionts that extend host nutrient uptake in exchange for photosynthate. Restored native grasslands and cover-cropped fields represent contrasting management strategies applied to former conventional farmland, differing in both tillage frequency and plant diversity, yet how these strategies shape AMF association in sandy, low-fertility soils remains largely understudied. We compared AMF colonization and spore communities between two adjacent sites converted approximately three years prior at the Bishop Farmstead, Southampton Township, NJ: a restored grassland dominated by Panicum virgatum and an agricultural field under white and red clover cover (Trifolium repens, T. pratense). Fine roots …
Oncogenic E-Cadherin-Dependent Metastasis And Potential Therapeutic Interventions, Madison K. Duenas, Anjela Anand, Paige Cano, Ralph Boccia, Mary Alpaugh
Oncogenic E-Cadherin-Dependent Metastasis And Potential Therapeutic Interventions, Madison K. Duenas, Anjela Anand, Paige Cano, Ralph Boccia, Mary Alpaugh
STEM Student Research Symposium Posters
Oncogenic E-cadherin-dependent metastasis is a paradoxical mechanism of cancer progression whereby E-cadherin, a cell-to-cell adhesion protein that normally suppresses tumor invasion, instead promotes the formation of cohesive cell tumor clusters that collectively invade surrounding tissues and metastasize. This phenomenon has been extensively studied using inflammatory breast cancer (IBC) models, including the MARY-X xenograft and SUM149 cell line, while comparisons with other breast cancer models such as MDA-MB-231 continue to provide insight into E-cadherin-independent metastatic mechanisms. This project reviews recent literature investigating the molecular mechanisms behind it and evaluates emerging therapeutic strategies targeting E-cadherin-associated cellular pathways. Laboratory techniques, including spheroid generation …
Bridging The Gap In Science Research: Preparing Students For College- Level Research In The Sciences, Victoria Helwig, Yaoguang Li
Bridging The Gap In Science Research: Preparing Students For College- Level Research In The Sciences, Victoria Helwig, Yaoguang Li
UConn Library Presentations
Many first-year students enter college unprepared to fully engage with scientific literature and academic library resources. Drawing on experiences from academic librarians working with STEM students, this session explores common gaps in science research skills, including navigating databases, identifying scholarly sources, and understanding the structure of scientific literature. Participants will be introduced to practical strategies and classroom-ready activities to better prepare students for college-level research. Discussion questions: What science research skills do students struggle with most when entering college? How can high school instruction better support these skills? Where can librarians and educators collaborate to support student success?
Environmental Dna For Endangered Freshwater Mussel Monitoring: A Review On Global Synthesis Of Edna Methods, Challenges, And Innovative Strategies, Mizanur Rahman, Md. Saydur Rahman, Richard J. Kline
Environmental Dna For Endangered Freshwater Mussel Monitoring: A Review On Global Synthesis Of Edna Methods, Challenges, And Innovative Strategies, Mizanur Rahman, Md. Saydur Rahman, Richard J. Kline
School of Earth, Environmental, & Marine Sciences Faculty Publications
Freshwater mussels (family Unionidae) are among the most endangered aquatic species worldwide, making effective monitoring vital for their conservation. Traditional surveys are laborious, time-consuming, and often miss rare or low-density populations. Environmental DNA (eDNA) is a highly sensitive, non-invasive approach for freshwater mussel detection and monitoring; however, uncertainties in ecological interpretation continue to limit its broader application in freshwater biodiversity monitoring. We conducted a systematic review of 49 peer-reviewed studies, identified through an extensive literature search, to assess temporal research trends, methodological advancements, ecological contexts, and regulatory readiness of freshwater mussel eDNA monitoring. Findings show that freshwater mussel eDNA research …
The Evolution Of Regulatory Architectures Underlying Phenotypic Plasticity, Shweta Agarwal
The Evolution Of Regulatory Architectures Underlying Phenotypic Plasticity, Shweta Agarwal
Biology ETDs
Phenotypic plasticity refers to a mechanism where a single genotype results in distinct phenotypes in response to distinct environments, making it a key mechanism for persistence under environmental change. Phenotypic plasticity can arise from two distinct regulatory architectures: epistatically regulated plasticity or environmentally sensitive loci. The evolutionary forces shaping these architectures remain unclear. I use the recombination modifier framework to explore how the regulatory architecture of plasticity evolves across a range of selection regimes, including the rate of environmental change and the costs and benefits of plasticity. I find that the evolution of the regulatory architecture of phenotypic plasticity requires …
Mapping And Modeling Threat-Evoked Brain States After Early Life Adversity, Taylor W. Uselman
Mapping And Modeling Threat-Evoked Brain States After Early Life Adversity, Taylor W. Uselman
Biomedical Sciences ETDs
Early life adversity (ELA) increases lifelong neuropsychiatric vulnerability. Yet how ELA reorganizes brain-wide activity and circuit coordination across later experience remains unclear. This dissertation tests the hypothesis that ELA alters adult brain-wide activity and responses to threat through disrupted coordination among neural systems that regulate emotional experience, including prefrontal-limbic and monoaminergic systems. Longitudinal manganese-enhanced MRI of adult mice exposed to standard or fragmented early care, combined with computational processing and statistical modeling, quantified brain states before, during, and long after innate predator threat. These studies established that acute threat evokes large-scale, distributed brain activity that evolves over time. ELA potentiates …
Ionophore-Based Plga Nanosensor For Selective Ion Detection And Imaging, Zhiyu Tang
Ionophore-Based Plga Nanosensor For Selective Ion Detection And Imaging, Zhiyu Tang
Electronic Theses and Dissertations 2020 - Present
Accurate detection of electrolyte ions is essential for biological research, disease diagnosis, and the investigation of cellular function. In this study, we developed ionophore-based PLGA nanosensors for the optical detection of biologically important ions. The nanosensors were prepared by encapsulating ionophores, chromoionophore III, and ion exchangers within PLGA nanoparticles. The resulting nanosensors showed uniform morphology, good colloidal stability, and concentration-dependent optical responses toward Na⁺, K⁺, and Ca²⁺ over the range of 10⁻⁶ to 10⁻¹ M. Reversible fluorescence responses under repeated ion concentration changes confirmed the stability and robustness of the sensors. The nanosensors also demonstrated reliable analytical performance for K⁺ …
Genetic Associations With Pulmonary Embolism Among Those With A Deep Vein Thrombosis: The International Network Against Venous Thrombosis Consortium, Susana Lozano-Esparza, Gabrielle E Shakt, Jennifer A Brody, Angel Martinez-Perez, Matthew P Conomos, Marine Germain, Katharine R Clapham, Maris Teder-Laving, Astrid Van Hylckama Vlieg, Anni Kauko, Florian Thibord, Ohanna C L Bezerra, Girish N Nadkarni, Gaëlle Munsch, Therese Haugdahl Nøst, Ellen L Goode, Yuekai Ji, Daniel I Chasman, Alexander P Reiner, Constance Turman, Kerri L Wiggins, Colleen M Sitlani, Juan Carlos Souto, Pamela L Lutsey, Tiffany Bellomo, Estonian Biobank, Million Veteran Program, Ruifang Li-Gao, Aleksi Kristian Winstén, Ming-Huei Chen, Ron Do, Lénaick Gourhant, Kristian Hveem, Sebastian M Armasu, Noémie Saut, Nathan Pankratz, Franco Giulianini, Jeffrey Haessler, Mingyang Song, Robert Olaso, Eric Boerwinkle, Daniel Dochtermann, Jose Manuel Soria, Stephen S Rich, David Smadja, Satoshi Koyama, Frits R Rosendaal, Teemu Niiranen, France Gagnon, Ha My T Vy, Neil Zakai, Catherine Lemarie, Anne Heidi Skogholt, Jean-François Deleuze, James S Pankow, Paul M Ridker, Yuxi Liu, Kenneth M Rice, Saiju Pyarajan, Mary Cushman, Jospeh Emmerich, Bruce M Psaty, Pradeep Natarajan, Andrew D Johnson, Marc A Rodger, Pierre Suchon, Francis Couturaud, Pierre-Emmanuel Morange, Weihong Tang, Charles Kooperberg, Christopher Kabrhel, Maria Sabater-Lleal, David-Alexandre Trégouët, Alisa S Wolberg, Scott M Damrauer, Nicholas L Smith
Genetic Associations With Pulmonary Embolism Among Those With A Deep Vein Thrombosis: The International Network Against Venous Thrombosis Consortium, Susana Lozano-Esparza, Gabrielle E Shakt, Jennifer A Brody, Angel Martinez-Perez, Matthew P Conomos, Marine Germain, Katharine R Clapham, Maris Teder-Laving, Astrid Van Hylckama Vlieg, Anni Kauko, Florian Thibord, Ohanna C L Bezerra, Girish N Nadkarni, Gaëlle Munsch, Therese Haugdahl Nøst, Ellen L Goode, Yuekai Ji, Daniel I Chasman, Alexander P Reiner, Constance Turman, Kerri L Wiggins, Colleen M Sitlani, Juan Carlos Souto, Pamela L Lutsey, Tiffany Bellomo, Estonian Biobank, Million Veteran Program, Ruifang Li-Gao, Aleksi Kristian Winstén, Ming-Huei Chen, Ron Do, Lénaick Gourhant, Kristian Hveem, Sebastian M Armasu, Noémie Saut, Nathan Pankratz, Franco Giulianini, Jeffrey Haessler, Mingyang Song, Robert Olaso, Eric Boerwinkle, Daniel Dochtermann, Jose Manuel Soria, Stephen S Rich, David Smadja, Satoshi Koyama, Frits R Rosendaal, Teemu Niiranen, France Gagnon, Ha My T Vy, Neil Zakai, Catherine Lemarie, Anne Heidi Skogholt, Jean-François Deleuze, James S Pankow, Paul M Ridker, Yuxi Liu, Kenneth M Rice, Saiju Pyarajan, Mary Cushman, Jospeh Emmerich, Bruce M Psaty, Pradeep Natarajan, Andrew D Johnson, Marc A Rodger, Pierre Suchon, Francis Couturaud, Pierre-Emmanuel Morange, Weihong Tang, Charles Kooperberg, Christopher Kabrhel, Maria Sabater-Lleal, David-Alexandre Trégouët, Alisa S Wolberg, Scott M Damrauer, Nicholas L Smith
Children’s Nutrition Research Center Staff Publications
Background: Venous thromboembolism (VTE) includes deep vein thrombosis (DVT) and pulmonary embolism (PE), the latter of which often originates from DVT and can be fatal.
Objectives: The aim of this study was to identify causal genetic factors that alter risk of PE among those with a presumed DVT.
Methods: Using a case-only design of VTE, we conducted meta-analyses of genome-wide association studies (GWASs) in the International Network Against Venous Thrombosis Consortium. Among participants diagnosed with VTE, each study identified those who had a clinically reported PE, with or without a clinically reported DVT; those remaining had isolated DVT. Logistic regression …
Oregon State Rank Assessment For Alpine Smelowskia (Smelowskia Ovalis), Lindsey K. Wise
Oregon State Rank Assessment For Alpine Smelowskia (Smelowskia Ovalis), Lindsey K. Wise
Institute for Natural Resources Publications
Oregon state conservation status assessment for Alpine smelowskia (Smelowskia ovalis) using NatureServe methodology, 2026.
Research Progress On Effect Of Salt On Pickling Vegetable Quality, Qi Kai, Li Ziyan, Cheng Wenbo, Fan Mingcong, Zuo Daoxi, Li Yan, Wang Li, Zhang Wenbin
Research Progress On Effect Of Salt On Pickling Vegetable Quality, Qi Kai, Li Ziyan, Cheng Wenbo, Fan Mingcong, Zuo Daoxi, Li Yan, Wang Li, Zhang Wenbin
Food and Machinery
Vegetable pickling is a time-honored food preservation and processing method, in which salt (primarily sodium chloride) plays an irreplaceable and core role. This paper systematically reviews the multidimensional effects of curing salt on vegetable quality. It comprehensively covers preservation mechanisms, textural transformations, the formation and conversion of flavor compounds, color stability, and nutritional value changes. Specifically, this article analyzes the decisive role of salt concentration gradients in final product characteristics. Furthermore, it examines the challenges posed by the low salinity, including microbial safety risks, textural deterioration, and flavor imbalances, while proposing corresponding strategies.
Plant Diversity Modifies Multi-Trophic Interactions In Croplands, Grasslands And Forests, Nian Feng Wan, Muyao Li, Siyuan Shen, Jun Xiang Zhou, Yu Tong Zhu, Ben A. Woodcock, Yue Qing Hu, Shinichi Nakagawa, David Tilman, Andy Hector, Michel Loreau, Peter B. Reich, Matteo Dainese, Forest Isbell, Bernhard Schmid, Kris A.G. Wyckhuys, Geoff M. Gurr, Linsheng Wan, Nico Eisenhauer, Yann Hautier, Anu Eskelinen, Richard D. Bardgett, Paul Kardol, Lauchlan H. Fraser, Qi Su, Shiyun Qiu, Yavanna Aartsma, Ramon Albajes, Matthias Albrecht
Plant Diversity Modifies Multi-Trophic Interactions In Croplands, Grasslands And Forests, Nian Feng Wan, Muyao Li, Siyuan Shen, Jun Xiang Zhou, Yu Tong Zhu, Ben A. Woodcock, Yue Qing Hu, Shinichi Nakagawa, David Tilman, Andy Hector, Michel Loreau, Peter B. Reich, Matteo Dainese, Forest Isbell, Bernhard Schmid, Kris A.G. Wyckhuys, Geoff M. Gurr, Linsheng Wan, Nico Eisenhauer, Yann Hautier, Anu Eskelinen, Richard D. Bardgett, Paul Kardol, Lauchlan H. Fraser, Qi Su, Shiyun Qiu, Yavanna Aartsma, Ramon Albajes, Matthias Albrecht
All Peer-Reviewed Publications
Multitrophic interactions can strongly influence the structure and functioning of ecosystems, but how plant diversity influences the direction and predictability of multitrophic interactions across agricultural and natural ecosystems remains unclear. Using 149 field studies across five continents, we found that, on average, increasing plant diversity tended to exert differential top-down and bottom-up effects in croplands versus grasslands and forests. Organic and nonorganic croplands exhibited 846 and 148% higher invertebrate natural enemy-to-herbivore abundance ratios under increased plant diversity, consistent with top-down control patterns where predator gains cause herbivore declines, enhancing crop outcomes. In grasslands and forests, increasing plant diversity was associated …
Oregon State Rank Assessment For Ithuriel's Spear (Triteleia Laxa), Lindsey K. Wise
Oregon State Rank Assessment For Ithuriel's Spear (Triteleia Laxa), Lindsey K. Wise
Institute for Natural Resources Publications
Oregon state conservation status assessment for Ithuriel's spear (Triteleia laxa)
using NatureServe methodology, 2026.
Using A Cell Flux Model To Investigate Phytoplankton Growth And Macromolecular Allocation Under Iron Limitation, Margaret Bernish, Meng Gao, Jongsun Kim, Benoit Pasquier
Using A Cell Flux Model To Investigate Phytoplankton Growth And Macromolecular Allocation Under Iron Limitation, Margaret Bernish, Meng Gao, Jongsun Kim, Benoit Pasquier
School of Earth, Environmental, & Marine Sciences Faculty Publications
Global biogeochemical models are powerful tools used to interpret observations and empirical data, create hypotheses, and make predictions. Many of these models, however, represent marine microbes as static stoichiometric reactions that convert nutrients into biomass. To better constrain the biological processes that control nutrient cycling in the global ocean, we extend the Cell Flux Model of Phytoplankton to explore the impact of dissolved iron concentration on the allocation of macromolecules and elemental ratios within phytoplankton cells. This model is supported by data obtained from a range of incubation experiments conducted with phytoplankton of varying species and size categories. Model output …
Oregon State Rank Assessment For Thompson Mistmaiden (Romanzoffia Thompsonii), Nora Dunkirk, Gabriel Campbell, Sue Vrilakas
Oregon State Rank Assessment For Thompson Mistmaiden (Romanzoffia Thompsonii), Nora Dunkirk, Gabriel Campbell, Sue Vrilakas
Institute for Natural Resources Publications
Oregon state conservation status assessment for Thompson mistmaiden (Romanzoffia thompsonii) using NatureServe methodology, 2026.
Cytotoxicity Of Bioactive Peptides From Cowpea (Vigna Unguiculata L. Walp) Against Breast Cancer Cells (Mcf-7), Dian R. Ningsih, Zusfahair Zusfahair, Ely Setiawan, Purwati Purwati, Kasta Gurning, Fitri A. Puspita Sari, Elya Widiawati
Cytotoxicity Of Bioactive Peptides From Cowpea (Vigna Unguiculata L. Walp) Against Breast Cancer Cells (Mcf-7), Dian R. Ningsih, Zusfahair Zusfahair, Ely Setiawan, Purwati Purwati, Kasta Gurning, Fitri A. Puspita Sari, Elya Widiawati
Karbala International Journal of Modern Science
Cancer is characterized by dysregulated metabolic signaling pathways, leading to uncontrolled cellular proliferation. Current cancer treatments, which involve surgery, radiotherapy, and chemotherapy, still cause adverse systemic toxicities. Accordingly, one possible effort that can be undertaken is to explore safe anticancer substances from protein sources such as peptides. Bioactive peptides can be isolated by hydrolyzing cowpea (Vigna unguiculata L. Walp) protein with trypsin. The objectives of this study were to isolate and fractionate bioactive peptides from cowpea, to determine the anticancer activity of peptide fractions, to identify active peptide fractions as anticancer agents using Liquid Chromatography High Resolution Mass Spectrometry …
Exogenous Ribosome Incorporation Induces Lineage Transdifferentiation In Intestinal And Liver Cancer Cells, Haoxuan Gu, Nadia Wahyuningsih, Keisuke Yamashita, Shota Inoue, Fuchao Tan, Mani Sharaki, Muhaimin Rifa’I, Kunimasa Ohta
Exogenous Ribosome Incorporation Induces Lineage Transdifferentiation In Intestinal And Liver Cancer Cells, Haoxuan Gu, Nadia Wahyuningsih, Keisuke Yamashita, Shota Inoue, Fuchao Tan, Mani Sharaki, Muhaimin Rifa’I, Kunimasa Ohta
Karbala International Journal of Modern Science
It has previously been shown that exogenous bacterial ribosomes added to somatic cells and various cancer cell lines generate ribosome-induced cell clusters (RICs) capable of transdifferentiating into multiple cellular lineages. However, the scope of ribosome-induced transdifferentiation in cancer cells remains poorly understood. This study aimed to analyze the effects of exogenous ribosome incorporation on human cancer cell lines, specifically the intestinal epithelial cell line Caco-2 and the hepatocellular carcinoma cell line HepG2. Caco-2 and HepG2 cells were cultured with purified bacterial ribosomes in human ES/iPS cell medium after trypsinization, resulting in the formation of ribosome-induced Caco-2 (RICs-Ca) and HepG2 (RICs-He) …
Selenoprotein P And Selenium As Potential Diagnostic Biomarkers For Breast Cancer Patients, Farah A. Rashid, Rawaa A. Ali, Hanaa A. Ali
Selenoprotein P And Selenium As Potential Diagnostic Biomarkers For Breast Cancer Patients, Farah A. Rashid, Rawaa A. Ali, Hanaa A. Ali
Karbala International Journal of Modern Science
Breast cancer incidence increases in last decade. Oxidative stress increases during cancer development causes consuming of antioxidants. Selenium and its transporting protein, selenoprotein P have an important role in redox homeostasis. This study aims to investigate whether or not selenium and selenoprotein P could be diagnostic biomarkers for breast cancer patients. This study was included 30 individuals in control group who is age- and BMI-matched with 60 breast cancer patients. Selenium was measured by colorimetric assay kit and selenoprotein P was determined by Sandwich ELISA kits. The results indicate significant decrease (p < 0.0001) of serum selenium and selenoprotein P in breast cancer patients compared to control. A positive significant correlation (r = 0.6214, p < 0.0001) was found between selenium and selenoprotein P in breast cancer patients. Selenium has an excellent diagnostic accuracy with area under curve 0.9831, sensitivity 95% and specificity 100% at cut-off less than 3.54 mmol/L. Furthermore, selenoprotein P has also an excellent area under curve 0.9958 with sensitivity 96.77% and specificity 100% at cut-off less than 4.15 ng/ml. These exploratory findings appear that selenium and selenoprotein P could be potential diagnostic biomarkers for breast cancer patients. Further investigations in large-multicenter populations are needed to confirm results.
Tapping Into The Ocean’S Hidden Energy: Feasibility Of A 5 Mw Otec Installation In North Bali, Widodo Setiyo Pranowo, Yani Permanawati, Gisela Malya Asoka Anindita, Agung Kurniawan, Albertus Sulaiman, Johar Setiyadi, Safri Burhanuddin, Ivonne Milichristi Radjawane, Hansan Park, Endro Sigit Kurniawan
Tapping Into The Ocean’S Hidden Energy: Feasibility Of A 5 Mw Otec Installation In North Bali, Widodo Setiyo Pranowo, Yani Permanawati, Gisela Malya Asoka Anindita, Agung Kurniawan, Albertus Sulaiman, Johar Setiyadi, Safri Burhanuddin, Ivonne Milichristi Radjawane, Hansan Park, Endro Sigit Kurniawan
Karbala International Journal of Modern Science
Indonesia is an archipelagic country surrounded by water and faces energy challenges due to the low use of renewable energy. Among the potential renewable options, marine energy is a particularly suitable resource given the country’s geographical nature. Based on this discussion, seawater temperature can be used as an alternative ocean thermal en-ergy known as ocean thermal energy conversion (OTEC) by using the difference in sea surface and deep-sea water temperatures. Therefore, this study aimed to examine OTEC installations in North Bali waters using closed-cycle OTEC calculations for a 5 MW system. Following this objective, we examined the water conditions by …
Surveying First-Year Stem Students’ Self-Reported Knowledge, Skills, And Attitudes Towards Teamwork, Gregory R. Goldsmith, Camilla Acosta
Surveying First-Year Stem Students’ Self-Reported Knowledge, Skills, And Attitudes Towards Teamwork, Gregory R. Goldsmith, Camilla Acosta
Biology, Chemistry, and Environmental Sciences Faculty Articles and Research
The ability to work in a team is cited as a key outcome for many undergraduate Science, Technology, Engineering, and Mathematics (STEM) programs, both as a method for improving learning and as a highly desired trait for employers. Despite a growing focus on teamwork, our ability to design appropriate teamwork curriculum is limited by our poor understanding of what students arriving at university know about teamwork, what teamwork skills they consider themselves to possess, and their attitudes towards teamwork. We delivered a mixed-methods survey to first-year STEM undergraduate students (n = 205) to benchmark knowledge, skills and attitudes towards …
Oregon State Rank Assessment For California Pinefoot (Pityopus Californicus), Lindsey K. Wise
Oregon State Rank Assessment For California Pinefoot (Pityopus Californicus), Lindsey K. Wise
Institute for Natural Resources Publications
Oregon state conservation status assessment for California Pinefoot (Pityopus californicus) using NatureServe methodology, 2026.
New Paradigm Of Forestry And Grassland Research Driven By Artificial Intelligence, Zhang Huaiqing, Jiaojun Zhu, Yang Liu, Tingdong Yang, Tian Gao, Jing Zhang, Xueyan Zhu, Yan Chen, Xian Jiang, Zeyu Cui, Jingwei Tan, Kexin Lei
New Paradigm Of Forestry And Grassland Research Driven By Artificial Intelligence, Zhang Huaiqing, Jiaojun Zhu, Yang Liu, Tingdong Yang, Tian Gao, Jing Zhang, Xueyan Zhu, Yan Chen, Xian Jiang, Zeyu Cui, Jingwei Tan, Kexin Lei
Bulletin of Chinese Academy of Sciences (Chinese Version)
Addressing the current limitations in forestry and grassland research, particularly in cross-scale system cognition, complex process mechanism representation, and multi-scenario simulation, this study proposes an artificial intelligence-driven paradigm reconstruction framework, to shift the research model from experience-oriented approaches toward data- and intelligence-driven integration. On this basis, the study systematically establishes a multidimensional mapping between artificial intelligence and forestry and grassland research across research objects, processes, and objectives, and clarifies their intrinsic coupling mechanisms and technical pathways. Furthermore, it develops a foundational capability system to support the new paradigm from four key dimensions: data, computing power, models, and applications. By examining …
Progress And Prospective Of New Pollutants Study, Ruan Ting, Chunyang Liao, Yawei Wang, Maoyong Song, Yaqi Cai, Guibin Jiang
Progress And Prospective Of New Pollutants Study, Ruan Ting, Chunyang Liao, Yawei Wang, Maoyong Song, Yaqi Cai, Guibin Jiang
Bulletin of Chinese Academy of Sciences (Chinese Version)
The governance of new pollutants has been becoming a critical strategic demand for the high-quality development of China. The policy will be further advanced during the coming National 15th Five-Year Plan period. Nevertheless, significant challenges remain in aspects such as list of controlled chemicals, standard development, measurement methods, alternative approaches, and remediation techniques. Existing experience in addressing traditional pollutants remains insufficient to adequately address the concealed and complex ecological and/or health risks associated with new pollutants. Thus, a strengthening of basic research is the optimal approach to tackling these challenges and avoiding detours. To better identify the critical scientific challenges …
Deciphering The Potential Of Monopterus Albus Protein Hydrolysate As A Therapeutic Candidate Against Cervical Cancer By Integrating Content Analysis, Network Pharmacology, And Molecular Docking, Okid Parama Astirin, Widya Mega Rahmawati, Elisa Herawati, Tetri Widiyani, Lili Pandan Sari, Sherly Octaviana
Deciphering The Potential Of Monopterus Albus Protein Hydrolysate As A Therapeutic Candidate Against Cervical Cancer By Integrating Content Analysis, Network Pharmacology, And Molecular Docking, Okid Parama Astirin, Widya Mega Rahmawati, Elisa Herawati, Tetri Widiyani, Lili Pandan Sari, Sherly Octaviana
Karbala International Journal of Modern Science
Cervical cancer has a high incidence rate in women, making the development of cancer drugs increasingly urgent. Asian swamp eel protein hydrolysate shows great promise as an anticancer candidate. This study aimed to reveal the potential of Asian swamp eel protein hydrolysate as an anticancer candidate in the cervix. Asian swamp eel protein hydrolysate was produced by hydrolyzing flesh with the enzyme alcalase. Compounds and peptides were identified using LC-HRMS. These compounds and peptides were analyzed using network pharmacology, gene ontology, and molecular docking. The results identified 153 endogenous compounds, including fatty acids and peptides. The key proteins targeted by …
Resource Assessment Report 9: South Coast Crustacean Resource 2045-25 Assessment, Emma-Jade Tuffley, Simon De Lestang
Resource Assessment Report 9: South Coast Crustacean Resource 2045-25 Assessment, Emma-Jade Tuffley, Simon De Lestang
Resource Assessment Reports
The South Coast Crustacean Resource (SCCR) comprises southern rock lobster (Jasus edwardsii), western rock lobster (Panulirus cygnus), crystal crab (Chaceon albus), giant crab (Pseudocarcinus gigas), and champagne crab (Hypothalassia acerba). The resource is accessed primarily by the South Coast Crustacean Managed Fishery (SCCMF), which operates between Augusta in the west and the South Australian border in the east. Since the 2022–23 season, the SCCMF has been managed under an Individual Transferable Quota (ITQ) system with Total Allowable Commercial Catches (TACs) set for four quota zones. Recreational fishing retains a small quantity of rock lobster only.
During the 2024–25 fishing season, …
Determinants Of Home Composting Behavior In Supporting Sustainable Agriculture Among Smallholder Farmers: A Case Study In The Thai Nguyen Province Of Vietnam, Bac Ho Van, Hien Vu Thi, Xinh Ho Luong
Determinants Of Home Composting Behavior In Supporting Sustainable Agriculture Among Smallholder Farmers: A Case Study In The Thai Nguyen Province Of Vietnam, Bac Ho Van, Hien Vu Thi, Xinh Ho Luong
Journal of Environmental Science and Sustainable Development
Home composting is a practical and sustainable approach for the management of organic waste generated in the home and agricultural production that contributes to both organic waste management and soil fertility enhancement. In the northern mountainous regions of Vietnam, smallholder farmers face limited adoption of sustainable waste management practices due to behavioral constraints, limited technical knowledge, and resource constraints affecting agricultural productivity. This study applies and extends the Theory of Planned Behavior (TPB) by integrating behavioral and contextual determinants to examine home composting adoption among smallholder farmers in rural Vietnam. Principal Component Analysis (PCA) was used to reduce and structure …