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Articles 3511 - 3540 of 52527
Full-Text Articles in Entire DC Network
Analyzing Human - Nonhuman Primate Conflict Mitigation Techniques In Mto Wa Mbu, Northern Tanzania, Lil Adams
Analyzing Human - Nonhuman Primate Conflict Mitigation Techniques In Mto Wa Mbu, Northern Tanzania, Lil Adams
Undergraduate Theses, Capstones, and Recitals
Human-wildlife conflict is a widespread challenge faced by those living in regular contact with wildlife that can have profound impacts on livelihood outcomes for humans, wildlife, and their shared environment (Barua et al., 2013; Blackie, 2023). Human – non-human primate conflict is particularly crucial due to primates’ high capacity to live among human populations (Chapman & Chapman, 1990; Alberts & Altmann, 2006; Reader et al., 2011; Sinha & Vijayakrishnan, 2017), and is currently on the rise due to increasing contact between human and non-human primates (Hockings, 2016; Uddin et al., 2020). To characterize and analyze techniques currently being used to …
Enhancing Water Scarcity Resilience In Egypt Through Machine Learning-Driven Phenological Crop Mapping And Water Use Efficiency Analysis, Surendra Maharjan, Wenzhao Li, Shahryar Fazli, Aqil Tariq, Rejoice Thomas, Cyril Rakovski, Hesham El-Askary
Enhancing Water Scarcity Resilience In Egypt Through Machine Learning-Driven Phenological Crop Mapping And Water Use Efficiency Analysis, Surendra Maharjan, Wenzhao Li, Shahryar Fazli, Aqil Tariq, Rejoice Thomas, Cyril Rakovski, Hesham El-Askary
Mathematics, Physics, and Computer Science Faculty Articles and Research
Agriculture forms the backbone of Egypt’s economy, with the Nile Valley and Delta serving as key production zones for crops like wheat, rice, and clover. However, the sector faces mounting pressure from water scarcity, as it depends almost entirely on the Nile for irrigation, making it necessary to map major crops for assessing Water Use Efficiency (WUE) and informing agricultural planning. In this study, we used machine learning (ML) techniques—specifically Support Vector Machine (SVM) to time-series phenological data and optical indices (Enhanced Vegetation Index (EVI), Bare Soil Index (BSI), Land Surface Water Index (LSWI), Normalized Difference Vegetation Index (NDVI), and …
Photochemistry Of Quinones And Combustion-Derived Particles, Desiree J. Sarmiento
Photochemistry Of Quinones And Combustion-Derived Particles, Desiree J. Sarmiento
Electronic Theses and Dissertations
Quinones are ubiquitous species that can be produced from the photochemical aging of combustion-derived particles (CDPs). Polycyclic aromatic hydrocarbons (PAHs) are a major component of CDPs and are precursors to quinones and other oxidized products (OPAHs). My work first expanded on the PAH and OPAH photochemistry research of Dr. John Haynes, who showed that anthracene (ANT) oxidizes into 1,4-naphthoquinone (1,4-NAPQ), 1,4-anthraquinone (1,4-ANTQ), and 9,10-anthraquinone (9,10-ANTQ), and of Dr. Heather Runberg, who demonstrated the ability of ANT and these quinones to generate reactive oxygen species (ROS). Then at the Pacific Northwest National Laboratory (PNNL), I was given the opportunity to investigate …
Foldit Education Mode, Brett Schulz
Foldit Education Mode, Brett Schulz
Electronic Theses and Dissertations
Foldit education mode is a puzzle campaign within the protein folding video game Foldit. Education mode, initially designed as a classroom supplement for undergraduate biochemistry courses, has been expanded to provide a more comprehensive learning tool to players without a background in biochemistry. The edited and added levels teach players about protein biochemistry through playing puzzles designed to convey information and gameplay mechanics. The new Foldit education mode campaign features 49 levels grouped into 11 categories. The campaign has 6 new levels designed specifically for education mode and 4 levels adapted from the traditional Foldit campaign for use within education …
Consumer Choice And Indoor Air Quality, Crystal Jadach
Consumer Choice And Indoor Air Quality, Crystal Jadach
Civil and Environmental Engineering Undergraduate Honors Theses
Outdoor air pollution has drastically improved for everyone since the passage of the clean air act. However, indoor air quality is not monitored or enforceable in the United States. Yet, the EPA estimates that people of developed nations spend approximately 90% of their time indoors. Candles, a common ambiance setting choice for many household consumers, have been well characterized as a source of volatile organic compounds (VOCs). VOCs can have a wide variety of negative effects on human health. A benchtop and pilot scale study were used to characterize the difference in the accumulation and displacement of total volatile organic …
Carbon Monoxide Releasing Polymeric Micelles, Riya Joshi
Carbon Monoxide Releasing Polymeric Micelles, Riya Joshi
Electronic Theses and Dissertations
Carbon monoxide (CO), traditionally known as a toxic gas, has emerged as a potential therapeutic agent due to its cytoprotective, anti-inflammatory, and vasodilatory properties. This study explores the development of CO-releasing polymeric micelles as a controlled delivery system for biomedical applications. Using ring-opening metathesis polymerization (ROMP), we synthesized diblock copolymers incorporating CO-releasing moiety diphenylcyclopropenone (DPCP) with hydrophilic polyethylene glycol (PEG) to enhance solubility and stability of the overall CO releasing system. Dynamic light scattering (DLS) and electron microscopy (EM) confirmed the formation of well-defined micelles, while fluorescence assays demonstrated efficient CO release with the use of Iridium photocatalyst under 470 …
Roles Of Organic Agriculture For Water Optimization In Arid And Semi-Arid Regions, Shikha Sharma, Matt A. Yost, Jennifer R. Reeve
Roles Of Organic Agriculture For Water Optimization In Arid And Semi-Arid Regions, Shikha Sharma, Matt A. Yost, Jennifer R. Reeve
Plants, Soils and Climate Student Research
Water scarcity is a critical challenge in arid and semi-arid regions, where agricultural water consumption accounts for a significant portion of freshwater use. Conventional agriculture (CA) methods with high reliance on chemical and mechanical inputs often exacerbate this issue through soil degradation and water loss. This review aims to examine how different organic practices, such as mulching, cover cropping, composting, crop rotation, and no-till (NT) in combination with precision technologies, can contribute to water optimization, and it discusses the opportunities and challenges for the adoption and implementation of those practices. Previous findings show that organic agriculture (OA) may outperform CA …
Assessment Of Walkability Of University Campus And Communities: Associations With Perceived Safety & Student Retention, Wendy Bjerke
Assessment Of Walkability Of University Campus And Communities: Associations With Perceived Safety & Student Retention, Wendy Bjerke
Exercise Science Faculty Publications
Introduction: Approximately 80% of Americans do not meet minimum guidelines for regular physical activity. Among ways to promote physical activity is to optimize the Built Environment to promote and increase access to walking and cycling. Walkable and accessible university campus environments and proximal communities can promote physical activity and are assessed and compared in this study. Purpose and Methods: Approximately 20 million students attend colleges and universities in the United States with over 100,000 students enrolled in the state of Connecticut. These students can potentially engage in physical activity within a campus or around the surrounding communities for university related …
Insights Into The Floral Senescence Effects Of Nanoparticles, Vuk Uskoković
Insights Into The Floral Senescence Effects Of Nanoparticles, Vuk Uskoković
Administration and Staff Articles and Research
Flowers could be valuable addenda to nanomedicine labs as in vivo models crossing the gap between the cell culture and small mammals. However, as it is shown here, floral models continue to be predominantly utilized within resource-limited research environments and remain largely underrepresented in mainstream biomedical investigations conducted by well-funded institutions in the developed world. The ability to delay the senescence of Orange Jubilee wildflowers was tested here on three types of nanoparticles: selenite-doped hydroxyapatite (HAp), citrate-stabilized HAp, and superparamagnetic iron oxide. Integration of selenite into the HAp crystal lattice produced a mild increase in the senescence rate …
Human Gut Commensal Alistipes Timonensis Modulates The Host Lipidome And Delivers Anti-Inflammatory Outer Membrane Vesicles To Suppress Colitis In An Il10-Deficient Mouse Model, Ethan Older, Mary K. Mitchell, Andrew Campbell, Xiaoying Lian, Michael Madden, Yuzhen Wang, Lauren E. Van De Wal, Thelma Zaw, Brandon N. Vanderveen, Rodney Tatum, E. Angela Murphy, Yan-Hua Chen, Daping Fang, Melissa Ellermann, Jie Li
Human Gut Commensal Alistipes Timonensis Modulates The Host Lipidome And Delivers Anti-Inflammatory Outer Membrane Vesicles To Suppress Colitis In An Il10-Deficient Mouse Model, Ethan Older, Mary K. Mitchell, Andrew Campbell, Xiaoying Lian, Michael Madden, Yuzhen Wang, Lauren E. Van De Wal, Thelma Zaw, Brandon N. Vanderveen, Rodney Tatum, E. Angela Murphy, Yan-Hua Chen, Daping Fang, Melissa Ellermann, Jie Li
Faculty Publications
Correlative studies have linked human gut microbes to specific health conditions. Alistipes is one such microbial genus negatively linked to inflammatory bowel disease (IBD). However, the protective role of Alistipes in IBD is understudied, and the underlying molecular mechanisms remain unknown. In this study, colonization of Il10-deficient mice with Alistipes timonensis DSM 27924 delays colitis development. Colonization does not significantly alter the gut microbiome composition, but instead shifts the host plasma lipidome, increasing phosphatidic acids while decreasing triglycerides. Outer membrane vesicles (OMVs) derived from Alistipes are detected in the plasma of colonized mice, carrying potentially immunomodulatory metabolites into the …
Lighting Up The Cell: Developing A Luminescent Lanthanide Probe For Detecting Rnas, Jonathan Savell
Lighting Up The Cell: Developing A Luminescent Lanthanide Probe For Detecting Rnas, Jonathan Savell
Honors Projects
An anion detecting luminescent probe, Tb:DO2A-Cs124, was repurposed for use in RNA imaging. Potential RNA aptamers were identified for the molecule using Capture-SELEX and MinION sequencing. Fluorimetry data revealed these aptamers did not allow for the probe to luminesce in the presence of target RNAs due to adenosine monophosphate’s ability to quench the emission signal.
Colonization-Persistence Trade-Offs In The Human Microbiome, Liam F. Nokes
Colonization-Persistence Trade-Offs In The Human Microbiome, Liam F. Nokes
Environmental Studies Senior Theses
Understanding how diverse microbial taxa coexist in the human body without competitively excluding one another remains a key challenge in microbiome ecology. One proposed explanation is the colonization-persistence trade-off, where species with high colonization ability are poor persisters, and vice versa. We test for this trade-off across human associated microbial communities among many individuals and in multiple body sites using a large-scale participant-level meta-analysis of longitudinal microbiome datasets curated from the MGnify database. We applied island biogeography-based models to calculate effective colonization and persistence rates for microbial families and genera across 606 individuals over twenty-six studies. Regression of the log-transformed …
Refinement And Application Of The Absorption Cross-Section Of Molecular Bromine With Relevance To Atmospheric Chemistry, Callum Flowerday, Ryan Thalman, Jaron C. Hansen, Eric T. Sevy, Jason J. Sorensen, Matthew C. Asplund
Refinement And Application Of The Absorption Cross-Section Of Molecular Bromine With Relevance To Atmospheric Chemistry, Callum Flowerday, Ryan Thalman, Jaron C. Hansen, Eric T. Sevy, Jason J. Sorensen, Matthew C. Asplund
ScholarsArchive Data
Defined Br2 XS - is the defined absorption cross-section using the UVvis spectrophotometer.
BBCEAS - This is raw absorption data measured using the BBCEAS (see article for details).
UVvis raw - This is the raw absorption data measured using the UVvis spectrophotometer.
Ensemble-Based Binding Free Energy Profiling And Network Analysis Of The Kras Interactions With Darpin Proteins Targeting Distinct Binding Sites: Revealing Molecular Determinants And Universal Architecture Of Regulatory Hotspots And Allosteric Binding, Mohammed Alshahrani, Vedant Parikh, Brandon Foley, Gennady M. Verkhivker
Ensemble-Based Binding Free Energy Profiling And Network Analysis Of The Kras Interactions With Darpin Proteins Targeting Distinct Binding Sites: Revealing Molecular Determinants And Universal Architecture Of Regulatory Hotspots And Allosteric Binding, Mohammed Alshahrani, Vedant Parikh, Brandon Foley, Gennady M. Verkhivker
Mathematics, Physics, and Computer Science Faculty Articles and Research
KRAS is a pivotal oncoprotein that regulates cell proliferation and survival through interactions with downstream effectors such as RAF1. Despite significant advances in understanding KRAS biology, the structural and dynamic mechanisms of KRAS allostery remain poorly understood. In this study, we employ microsecond molecular dynamics simulations, mutational scanning, and binding free energy calculations together with dynamic network modeling to dissect how engineered DARPin proteins K27, K55, K13, and K19 engage KRAS through diverse molecular mechanisms ranging from effector mimicry to conformational restriction and allosteric modulation. Mutational scanning across all four DARPin systems identifies a core set of evolutionarily constrained residues …
Detecting Physical Activity Using Wearable Sensor Data, Dipok Deb
Detecting Physical Activity Using Wearable Sensor Data, Dipok Deb
Data Science and Data Mining
This study focuses on detecting physical activity using wearable sensor data, specifically distinguishing between walking and running. A dataset comprising accelerometer and gyroscope readings is used to train and evaluate various machine learning models, including logistic regression, random forest, k-nearest neighbors, naïve Bayes, and XGBoost. Extensive preprocessing, such as creating lag features and rolling statistics, is performed to enhance temporal data representation. The models are evaluated using metrics like accuracy, precision, recall, and F1 score. Incorporating lag and rolling features significantly improves model performance, with logistic regression achieving perfect scores across all metrics. These findings demonstrate the effectiveness of enhanced …
Creation Of An Open Access Textbook, Sue Ann Gardner
Creation Of An Open Access Textbook, Sue Ann Gardner
University of Nebraska-Lincoln Libraries: Presentations
Slide presented during the PRCA Research Celebration, June 3, 2025, in the University Libraries, University of Nebraska-Lincoln titled Creation of an Open Access Textbook, about the development and publication of Concepts in Animal Parasitology, co-edited by Scott L. Gardner and Sue Ann Gardner and published by Zea Books (Lincoln, Nebraska, USA) in 2024.
Posterior Predictive Design For Phase I Clinical Trials, Chenqi Fu, Shouhao Zhou, J Jack Lee
Posterior Predictive Design For Phase I Clinical Trials, Chenqi Fu, Shouhao Zhou, J Jack Lee
Faculty, Staff and Student Publications
Interval-based designs represent cutting-edge adaptive methodologies for phase I clinical trials to identify the maximum tolerated dose (MTD). These designs exhibit robust performance comparable to more intricate, model-based designs, and their pretabulated decision rule enables them to be implemented as simply as the conventional algorithm-based designs. In this paper, we introduce the posterior predictive (PoP) design, a novel interval-based design that leverages advanced Bayesian predictive hypothesis testing techniques for dose escalation and de-escalation. Our work moves beyond the existing model-assisted interval-based designs by achieving global optimality in dose transition. Theoretically, the global optimality ensures that the proposed design can consistently …
Arts-Based Sustainability: From New York To Malawi, Martha B. Lerski
Arts-Based Sustainability: From New York To Malawi, Martha B. Lerski
Publications and Research
Recognizing that libraries serve multiple constituencies and subject areas, this chapter documents and advocates for development of transdisciplinary arts-based research (ABR) and culture-related projects linked to environmental challenges. Libraries contribute collections and spaces, as well as the research of library and information scientists. Libraries are currently among invisible contributors to sustainability planning and services. The chapter will link this invisibility to the value of what visual arts refer to as negative space elements in subjects ranging from traditional ecological knowledge to environmental science. Library collections, projects, and research contribute to education for sustainable development (ESD) as required to achieve the …
The Ecophysiology Of The Enigmatic Namib Succulent, Lithops Ruschiorum, Garrett Macleod Althausen
The Ecophysiology Of The Enigmatic Namib Succulent, Lithops Ruschiorum, Garrett Macleod Althausen
Environmental Studies Senior Theses
Water availability is the primary constraint for plant survival and reproduction in hyper-arid ecosystems. In such environments, plant fitness depends on an alignment between physiological traits and limited water resources. The Namib Desert of Namibia exemplifies this extreme selection pressure. Within the Namib Desert, Lithops ruschiorum, a succulent endemic to the gravel plains, exhibits habitat specificity and numerous physiological adaptations to cope with the hyper-aridity.
This research explores the intersection of two fitness strategies for L. ruschiorum: habitat selection and exploitation of alternative moisture sources. The first chapter explores the population dynamics and micro-site habitat conditions preferred by …
Exploring Soft Polymeric Nanoparticles For Targeted Biomolecule Delivery In Plant Cells, Mohammad Rashid
Exploring Soft Polymeric Nanoparticles For Targeted Biomolecule Delivery In Plant Cells, Mohammad Rashid
Theses and Dissertations
Safe and efficient agricultural practices require innovative technologies. Nanotechnology offers promising solutions for advancing plant agriculture by enabling the targeted delivery of biomolecules such as agrochemicals and nucleic acids. This study focuses on developing a safe nanotechnological approach for delivering molecules of interest into plant cells. We investigated the ability of four types of polymeric nanoparticles such as Polyethylene glycol N, Nʹ-dibutylethylenediamine (PEG-DB), Polyethylene glycol 2-pyrrolidin-1-yl-ethyl-amine (PEG-PY), Polyethyleneimine (PEI), Arabinoxylan (AX)+, and Zein+ to form conjugates with plasmid DNA (pDNA). Our findings confirm that plant-derived cationic nanopolymers, AX+ and Zein+, effectively bind negatively charged pDNA (pGFPGUSPlus) carrying a GFP reporter …
Enhancing Stability And Emissions In Metal Halide Perovskite Nanocrystals Through Mn2+ Doping, Thi Thu Trinh Phan, Thi Thuy Kieu Nguyen, Trung Kien Mac, Minh Tuan Trinh
Enhancing Stability And Emissions In Metal Halide Perovskite Nanocrystals Through Mn2+ Doping, Thi Thu Trinh Phan, Thi Thuy Kieu Nguyen, Trung Kien Mac, Minh Tuan Trinh
Chemistry and Biochemistry Student Research
Metal halide perovskite (MHP) nanocrystals (NCs) offer great potential for high-efficiency optoelectronic devices; however, they suffer from structural softness and chemical instability. Doping MHP NCs can overcome this issue. In this work, we synthesize Mn-doped methylammonium lead bromide (MAPbBr3) NCs using the ligand-assisted reprecipitation method and investigate their structural and optical stability. X-ray diffraction confirms Mn2+ substitution at Pb2+ sites and lattice contraction. Photoluminescence (PL) measurements show a blue shift, significant PL quantum yield enhancement, reaching 72% at 17% Mn2+ doping, and a 34% increase compared to undoped samples, attributed to effective defect passivation and …
Understanding The Habitat Associations Of Nearshore Rockfishes Inside And Outside Of Marine Protected Areas Using Hook-And-Line Data, Kaila Raeanne Fritch
Understanding The Habitat Associations Of Nearshore Rockfishes Inside And Outside Of Marine Protected Areas Using Hook-And-Line Data, Kaila Raeanne Fritch
Master's Theses
Habitat is an important driver in shaping the distribution of a range of species. For demersal fish species, benthic habitat characteristics can drive distribution and community structure. Understanding the relationship between habitat and species distribution in important, especially for exploited species such as rockfishes (Sebastes spp.). Increased data on the relationship between rockfish and benthic habitat characteristics could enhance marine protected areas (MPAs) and management practices which are used to protect rockfishes along the U.S. West Coast. To address this, we used hook-and-line, catch-and-release data that were collected inside two MPAs on the central coast of California, and …
Subalpine And Alpine Plant Community Turnover In Yosemite National Park Following 30 Years Of Climate Warming, Rachel Friesen
Subalpine And Alpine Plant Community Turnover In Yosemite National Park Following 30 Years Of Climate Warming, Rachel Friesen
Master's Theses
Subalpine and alpine regions in California are warming more rapidly than lower elevations. In response, high-elevation plants may acclimate or adapt to the new climate, move to higher elevations or latitudes, persist in refugia, or go extinct. While models predict substantial declines in subalpine and alpine plant communities due to discontinuous population distributions and lack of upslope area, actual responses may vary due to lags in dispersal, establishment, and extinction. Although shifts in high-elevation plant communities have been documented in other regions of the world, such changes have not yet been studied in Yosemite National Park. To assess high-elevation plant …
When Trees Disappear: Understory Successional Implications Of Sudden Oak Death And High-Severity Wildfire In Big Sur, California, Sam J. Balthazard
When Trees Disappear: Understory Successional Implications Of Sudden Oak Death And High-Severity Wildfire In Big Sur, California, Sam J. Balthazard
Master's Theses
The rapidly emerging disease sudden oak death, caused by the non-native pathogen Phytophthora ramorum, is transforming coastal California forests by driving extensive mortality of tanoak (Notholithocarpus densiflorus) and increasing fire severity. As a novel disturbance, sudden oak death and its interaction with wildfire may catalyze unexpected shifts in successional trajectories and reconfigure forest understory communities. Furthermore, how tanoak influences the forest understory and how its decline might reshape understory dynamics remain poorly understood. We hypothesize that disease alone and the compounding disturbances of disease and wildfire alter successional dynamics, and that the potential functional extinction of N. …
Capfish Project Report : Summer Academy For The Pacific Islands, Kathleen Auld, Francis Neat, Raphaël Baumler
Capfish Project Report : Summer Academy For The Pacific Islands, Kathleen Auld, Francis Neat, Raphaël Baumler
Reports
The CAPFISH Project was created in response to an identified need for capacity-building to address illegal, unreported and unregulated (IUU) fishing and related matters - a complex problem affecting aquatic ecosystems, coastal communities, fishers and fish workers, and economic and national security. Over the last four years, the CAPFISH Project has provided training and educational materials on IUU fishing to developing country administrations around the world, most recently with a two-week regional Summer Academy for the Pacific Islands. This Academy ran for two weeks and included delegates from fisheries, labour, safety, maritime, foreign affairs, and enforcement administrations in the Pacific …
Effects Of Probiotic Supplementation On Growth Performance, Nutrient Digestibility, And Enteric Methane Emission Of Growing Dairy Buffaloes (Bubalus Bubalis L.), Christian Lualhati, Karl Reginald Managa, Charity Castillo, Phoebe Lyndia Llantada, Arnel Del Barrio
Effects Of Probiotic Supplementation On Growth Performance, Nutrient Digestibility, And Enteric Methane Emission Of Growing Dairy Buffaloes (Bubalus Bubalis L.), Christian Lualhati, Karl Reginald Managa, Charity Castillo, Phoebe Lyndia Llantada, Arnel Del Barrio
The Philippine Agricultural Scientist
This study assessed the impact of probiotics on the growth performance, nutrient digestibility, and enteric methane emission of 4 growing dairy buffaloes (Bubalus bubalis L.) with similar body weight, age, and sex. The animals were allocated into 4 treatments following a Latin Square design: control/no probiotic supplement (Trt 1); with 5 mL of probiotic supplement (Trt 2); with 10 mL of probiotic supplement (Trt 3); and with 15 mL of probiotic supplement (Trt 4). The growers were offered the dietary treatments at the start of the adaptation phase up to the end of the experimental phase per period. Animals …
Arkansas Corn And Grain Sorghum Research Studies 2024, Jason Kelley, Travis Faske
Arkansas Corn And Grain Sorghum Research Studies 2024, Jason Kelley, Travis Faske
Arkansas Agricultural Experiment Station Research Series
The 2024 edition of the Arkansas Corn and Grain Sorghum Research Studies Series includes research results on topics pertaining to corn and grain sorghum production, including weed, disease, nematode, and insect management; economics; irrigation; agronomics; soil fertility; drone use; and research verification program results.
Our objective is to capture and broadly distribute the results of research projects funded by the Arkansas Corn and Grain Sorghum Board. The intended audience includes producers and their advisors, current investigators, and future researchers. The Series serves as a citable archive of research results.
The reports inform and guide our long-term recommendations, but should not …
Graduate School Blog - June 2025, Cynthia Haynes
Graduate School Blog - June 2025, Cynthia Haynes
UofM Grad School Blog
The June 2025 edition of the UofM Graduate School Blog helps prospective and current students make informed financial decisions with Part 1 of the Graduate School Cost Guide, breaking down tuition structures such as per-credit hour versus flat-rate models, highlighting UofM’s tuition cap for in-state students, and explaining key university fees and cost differences between online and on-campus formats. The blog also features Brianna Reilly, a Doctor of Musical Arts graduate from New York, who shares how a graduate assistantship and her passion for music education led her to continue at UofM through the pandemic. Additional resources include an …
Topodino: Self-Supervised Topological Representation Learning For Neuronal Morphologies, Yasser Binbisher
Topodino: Self-Supervised Topological Representation Learning For Neuronal Morphologies, Yasser Binbisher
Master's Theses
Neuronal cell types are categorized by transcriptomic identity, yet their morphological heterogeneity defies this classification. In response, researchers have adopted unsupervised graph representation learning as a tool to reveal morphological variation within single-class transcriptomic types. However, the complex geometry of neuronal morphology—especially long axons and dense dendrites—challenges graph neural networks, which struggle with message propagation across extended structures. To mitigate this, current approaches enforce sub-sampling on neuronal graphs and omit axons entirely, sacrificing critical biological features for computational efficiency. To overcome this trade-off, this thesis introduces TopoDINO, a self-supervised, topology-aware representation learning model designed to preserve the full hierarchical organization …
Stability Insights From Modeling Chronic Myelogenous Leukemia, Giovani Thai
Stability Insights From Modeling Chronic Myelogenous Leukemia, Giovani Thai
Master's Theses
This thesis centers around a model for chronic myelogenous leukemia (CML) as it behaves under imatinib treatment, a common medication for CML patients, and the anti-leukemia immune response. The dynamics are represented with a system of nonlinear delay-differential equations first constructed by Kim et al. in 2008, capturing population changes of T-cells and various CML growth stages. We investigate stability in both the clinical and mathematical sense. Through numerical simulations, we computationally incorporate a supplementary treatment plan to determine its effectiveness in aiding immune response and medication in achieving remission and full elimination. The primary goal is to conduct a …