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Folic Acid–Carbon Dot–Gemcitabine Nanoparticles For Targeted Cancer Drug Delivery, Irfan Huda, Hua Mei

SPARK Symposium Presentations

This project aims to develop a folic acid-attached carbon dot nanoparticle system (FA-CDs-GEM) for the targeted delivery of gemcitabine to cancer cells. While gemcitabine is widely used, its effectiveness is limited because a short in vivo half life and lack of selectivity, which lead to severe side effects. Carbon dots offer a simple and modifiable platform as the drug delivery and bioimaging agent. Conjugation of folic acid to the carbon dots enables selective targeting of cancer cells that overexpress folate receptors. In this study, we synthesized and characterized FA-CD-GEM nanoparticles and developed an HPLC calibration curve of GEM to accurately …

Enhancing Urban Garden Capacity By Linking Biodiversity And Ecosystem Function, Mary T. Nguyen, Carleen Rauh, Shelby Gresch, Charlotte Correiro, Heidi Elmendorf, Adriane Fugh-Berman, Gina Wimp, Alexandra L. Decandia

Virginia Journal of Science

Urban agriculture broadly describes food and plant cultivation in metropolitan areas. While biodiversity is thought to support ecosystem health and resilience, the relationship between above-ground and below-ground diversity has been understudied in urban green spaces. This study examines plant, animal, bacterial, and fungal diversity across three distinct urban habitats: a turf lawn, a forb garden, and a farming space. Using bacterial 16S rRNA and fungal ITS2 sequencing, soil nutrient analyses, and surveys of vegetation and wildlife, we connect diverse philosophies in urban agriculture to their role in advancing community diversity and ecosystem function. We found that different urban gardens support …

Interspecific Overlap In Seabird Diet Throughout The Breeding Season, Alexis V. Berkey

Student Publications

Seabirds are central-place foragers that breed in multi-species colonies, providing an opportunity to study species coexistence. I quantified interspecific competition among four seabird species (common terns Sterna hirundo, Arctic terns Sterna paradisaea, Atlantic puffins Fratercula arctica, black guillemots Cepphus grylle) breeding in the Gulf of Maine in 2022, 2024, and 2025. I hypothesized that, throughout the breeding season, 1) seabird diet would change and 2) interspecific overlap in diet would increase. I compared diets across species and time using direct observation of prey feeds and stable isotope values of seabird egg membranes and blood, which provide …

Evolution As Spatial Projection, Charles H. Smith, Ngoc Nguyen

Faculty/Staff Personal Papers

A theory combining explanations for the nature of three-dimensional systems and evolutionary processes is advanced, set to a geometric simulation, and then discussed in the context of several empirical studies bearing on its validity. The concept “evolution” is first discussed, then related to Baruch de Spinoza’s ideas on natural philosophy, including his concept of the conatus. These ideas are then extended by posing the possible existence of a general form of natural systems subsystemization leading to the extended space condition. A geometrical/topological simulation study projecting spatial relations among subsystem structures interpretable through entropy maximization and multidimensional scaling methods is presented, …

Imidacloprid Effects On The Survival And Cutaneous Microbiome Of Northern Leopard Frogs, Evelyn Margaret Osterloo

Honors Thesis

Amphibians are experiencing population declines due to habitat loss, climate change, and diseases, particularly chytridiomycosis caused by the fungus Batrachochytrium dendrobatidis. Protection from this fungal infection stems from the cutaneous microbiome. Pesticides have been shown to affect amphibians in a variety of ways, including reducing survival, locomotor performance, and accumulation in body tissues. Pesticides may also lead to changes in the cutaneous microbiome affecting amphibians who rely on these organisms as an anti-Bd defense mechanism. To investigate the effect of imidacloprid, a neonicotinoid insecticide, Northern Leopard frogs (Lithobates pipiens) were subjected to sublethal concentrations (control = …

Increased Backbone Rigidity Of Artificial Transcription Factors, Jasmine Glover, Emma Otey, Joanna K. Kwao, Nicholas Truex

Senior Theses

Programming DNA-binding proteins is an effective strategy for developing therapeutics that regulate gene expression. These proteins can directly bind to DNA to activate or repress transcription of specific genes. Zinc finger proteins are a class of DNA-binding proteins commonly found in eukaryotic organisms. Their DNA-binding function is derived from unique amino acid sequences within each domain that recognizes specific nucleotides, allowing each finger to selectively recognize three DNA base pairs. Adjoining of multiple domains in tandem allows recognition of a specific DNA sequence. Artificial transcription factors can be made of multiple zinc finger domains arranged in tandem and engineered to …

The Importance Of Body Size And Spatial Scale In Modeling Winter Bird Distributions, Carissa M. Mobley

Student Publications

Birds’ annual cycles include biologically linked breeding and non-breeding seasons, yet most research and bird atlases focus exclusively on the breeding season. There have been very few winter bird atlas projects in North America, and none have been published for the northeastern United States. Short daylight hours and harsh weather limit winter survey coverage, making species distribution models (SDMs) essential for addressing spatial gaps.

I evaluated the optimal spatial scale for SDMs across bird species differing in body size and tested whether optimal scale varies with body mass. Using 16,967 eBird checklists collected during the first winter survey period (December …

Raptor Abundance And Occupancy In Urban Parks Within Metropolitan Landscapes, Mary- Esther Leblanc

Posters - 2026

Rapid urbanization is one of the most significant and accelerating drivers of global biodiversity change, reshaping wildlife communities by fragmenting habitat, altering prey availability, and introducing human disturbances. Despite these pressures, some wildlife species are attracted to and may even flourish in urban settings, primarily because urbanization creates an altered landscape that often unintentionally provides resources functioning as components of habitat. (Chiron et al., 2024) Raptors, as apex predators within avian food webs, offer a valuable lens through which to examine these dynamics. While raptor communities are broadly negatively impacted by urbanization, some species can thrive in urban areas. (Leveau …

Polylactic Acid (Pla) Microplastic Toxicity In C. Elegans, Maria Gamez, Dana Farley, Chiara Maldonado, David Mares

Posters - 2026

• Microplastics (MPs, > 5 mm1) are an environmental pollutant that pose health risks to humans. • Primary MPs are created for direct use or plastic stocks, and secondary MPs are created when plastics in the environment break down over time. • Microplastic exposure can cause oxidative stress, metabolic disorders, immune responses, neurotoxicity, and reproductive issues2-3. • Polylactic Acid (PLA) is a biodegradable plastic used in everyday items, such as food packaging, and as a polymer in 3D printing. • PLA exposure to fish causes organ damage5 and C. elegans exposure to primary PLA MPs and UV-aged MPs reduced reproduction6-7 . …

Bird Population Response To Abiotic And Biotic Stresses In Urban & Restored Oak Savannah Habitat, Annabelle Ball

Posters - 2026

Birds are heavily impacted by urban development. Many experience habitat fragmentation and removal of food sources. However, other species can adapt to and even thrive in urban environments, thanks to certain tree species, bird feeders, and buildings. In North America, the house sparrow and the European starling are invasive species that benefit from urban environments (Bartelt, 2011; Fitzwater, 2014). Meanwhile, many habitats across the continent are experiencing restoration/rewilding efforts for the benefit of birds. One such habitat is the oak-savannah, which is characterized by 10-30% canopy cover and a mixture of prairie & woodland vegetation, supporting a high diversity of …

Saved From The Brink Of Collapse: Evaluating The Success Of The Sussex Kelp Recovery Project, Keagan Farrell, Kelly Swyers, Adan Vasquez

Posters - 2026

Kelp forests are vital to ocean health, they provide habitat, food, and nursery grounds for a variety of marine species. These forests support fisheries, improve water quality, and help to protect coastlines (Eger et al. 2024). The Sussex Kelp Recovery Project is a marine conservation effort aimed at restoring their kelp forests along the Sussex coastline in southern England. This area lost up to 96% of its forests mainly due to the fishing practice trawling. Trawling is used to gather large amounts of fish, while dragging a net at the seafloor (Our history 2026). The main goal of the Sussex …

International Rice Outlook: International Rice Baseline Projections 2025-2035, A. Durand-Morat, W. Mulimbi

AAES Research Reports and Research Bulletins

• Over the next ten years, global rice consumption is projected to exceed global rice production, making existing stocks crucial for meeting the global rice market demand. • Global production is projected to grow mostly due to productivity gains and some area expansion, with India’s production performance becoming more relevant. • The global rice consumption is projected to climb, driven mainly by population growth. The average global per capita rice consumption is expected to drop slightly over the next decade, primarily due to slower per capita consumption growth in Asia and Africa. • The international prices of long-grain and medium-grain …

Biol 454: Developmental Biology (Syllabus), Travis Bailey Ph.D.

School of Arts & Sciences

This syllabus was developed by SUNY Geneseo Professor Travis Bailey in the spring 2026 semester.

Learning Outcomes-Students will:

• Understand the methods scientist use to explore the genetic, cellular, and tissue control of development.
• Compare and contrast developmental strategies of model organisms.
• Read primary literature critically and explain strengths and weaknesses.
• Test hypotheses with self-designed experimentation, measurement and data collection, evaluation of evidence, and employment of mathematical analysis.
• Relate discoveries from model animals to human conditions.
• Communicate findings orally and in writing.
• Integrate multiple bodies of knowledge with their personal experience by asking meaningful questions about real-world problems
• Apply skills, theories, …

Leveraging Aspiring And Inspiring Mentorship Relationships To Promote Stem Persistence, Rayann K. Hoppe

Honors Thesis

While several mentorship interventions for STEM students already exist, persistence and retention in STEM fields remain relatively low. Additionally, there is limited research examining the intersections between aspiring (upward) and inspiring (downward) mentorship roles.

This article aims to address these gaps by examining existing literature and mentorship frameworks, with a focus on how mentorship dynamics influence STEM persistence. Two principal findings emerge from the literature: (1) effective mentorship should be conceptualized as an interconnected ecosystem rather than a hierarchical structure, and (2) the intersection of aspiring and inspiring roles contributes to the development of identity, self-efficacy, and a sense of …

Gompertz Growth With A Shared Carrying Capacity Optimally Simulates Primary And Metastatic Tumor Growth Dynamics, Pirmin Schlicke, Preethi Korangath, Xiaoxi Pan, Caner Ercan, Kathleen Gabrielson, Lyndsey Werhane, Yinyin Yuan, Sébastien Benzekry, Robert Ivkov, Heiko Enderling

Faculty, Staff and Student Publications

Background: Cancer is a systemic disease with most deaths attributed to metastatic burden. Primary and metastatic tumors, albeit at different anatomic locations, are interconnected through multiple biological processes. Pre-clinical and clinical observations of growth acceleration of metastases after surgery, or abscopal effects outside the radiation field are widely reported, yet reliably triggering favorable and avoiding unfavorable systemic responses remains an unmet clinical need. Understanding local and systemic tumor interaction dynamics will help guide future treatments.

Methods: We analyze the data of multiple in vivo tumor models. We formalize the systemic interplay of tumors as mathematical differential equation and calibrate parameters …

Quantifying Nutrient Fluxes Across The Sediment-Water Interface In The Lafayette River Estuary, Adriana E. Amrhein

OES Theses and Dissertations

The Lafayette River, a shallow, eutrophic tributary of the Chesapeake Bay, experiences seasonal harmful algal blooms (HABs). While management efforts focus on reducing external nutrient inputs, internal loading from benthic sediments remains poorly constrained. This study quantifies spatial and seasonal variability in nutrient and radium isotope fluxes across the sediment–water interface at three sites where HABs are known to initiate and represent contrasting sediment textures and hydrodynamic conditions. Sediment cores and porewater samples were collected in summer 2023 and winter 2024 to measure grain size, porosity, dissolved nutrients (NH₄⁺, NOₓ⁻, PO₄³⁻), and radionuclide activities (²²⁴Ra and ²²⁸Th). Radium isotope disequilibrium …

Dissecting The Etiology Of Alcohol Use Disorder By An Integrative Heritable Component Approach, Ivy Garrenton

Computer Science Theses & Dissertations

Alcohol Use Disorder (AUD) is a pervasive condition characterized by complex interplay among genetic, phenotypic, and environmental factors. Although previous studies have identi fied genetic loci associated with alcohol consumption, these efforts have not captured the genetic heterogeneity and gene-environment interactions underlying AUD pathogenesis. To address this critical gap, we developed a novel statistical methodology that integrates phenotypic, genotypic, and environmental data through an environmentally modified Genetic Relationship Matrix (GRM) to derive AUD-related traits with enhanced heritability.

This approach demonstrated superior performance in both simulated and real-world datasets. Traits derived using the environmentally modified GRM exhibited significantly higher estimated heritability …

Dendrimer Nanogels With Built-In Free Radical Scavenging Enable Efficient Topical Delivery Of A Hydrophilic Antioxidant To Restore Lens Redox Balance For Cataract Treatment, Lin Qi, Huari Kou, Anna Chernatynskaya, Da Huang, Vimalin Jeyalatha Mani, Humeyra Karacal, Nuran Ercal, Hu Yang

Chemistry Faculty Research & Creative Works

Cataract is a leading cause of vision impairment worldwide and are primarily caused by oxidative stress that damages and aggregates lens proteins, leading to lens opacification. However, the eye's anatomical barriers limit the penetration and bioavailability of antioxidant therapies. To address this challenge, a dendrimer-based nanogel with a built-in reactive oxygen species (ROS)-scavenging capability developed by us was employed to deliver the antioxidant N-acetylcysteine (NAC) to the lens. NAC was loaded into a generation-5 PEGylated poly(amidoamine) dendrimer (G5-PEG-TK, termed the GPT) nanogel. The resulting NAC-GPT was characterized for its ROS-scavenging activity, bioavailability, and corneal permeability. The efficacy of NAC-GPT was …

Optimizing Barley Stripped Mosaic Virus Coat Protein Stability For Palladium Nanorod Biotemplating Via Terminal His-Tag Positioning, Emilie Hayes

Honors Theses

Viral biotemplating has become an exciting approach towards the production of nanomaterials with a controlled size and morphology. Rod-shaped plant viruses provide structurally consistent scaffolds that can guide the assembly of inorganic nanostructures, which can offer a biologically inspired platform to nanoscale material design. In the current study, computational modeling was used to examine the effect of palladium precursor chemistry on the reaction with viral protein templates. Molecular dynamics simulations were performed to test the stability of the viral scaffold, and the influence of N-terminal and C-terminal His-tag on protein flexibility. These simulations revealed that the viral coat protein is …

Perspective In Biomedical Sciences Field: Education And Career, Fitra Adi Prayogo, Mellyaning Oktaviani Sonya Kirana Sari, Isy Royhanaty, Poppy Fansisca Amelia, Heni Wijayanti, Ni Nyoman Maryaningtyas Adinatha, Dyah Wulandari, Anto Budiharjo

Chulalongkorn Medical Journal

Abstract

Background: The biomedical sciences represent a dynamic and multidisciplinary field pivotal to advancing human health through research, education, and innovation.

Objective(s): This review explores the evolving landscape of biomedical education and career pathways, driven by technological advancements, interdisciplinary integration, and global health demands.

Methods: We examine the distinctions between biomedical science, biomedicine, and biomedical engineering, highlighting their historical origins and contemporary roles. The education and career trajectories of biomedical laboratory scientists (BLS) are analysed, emphasising diverse competencies, core curricula, and the impact of regional policies on professional qualifications. Emerging trends and ethical/regulatory challenges are discussed.

Result(s): Key trends include …

Optimal Control Strategies For Infectious Diseases: A Numerical Simulation Approach, M. Abu Salek, Jannatun Nayeem, Romana Yesmin, M. Haider Ali Biswas, M. Humayun Kabir

Mathematical Modelling and Numerical Simulation with Applications

Various infectious diseases, such as Tuberculosis and Hepatitis B virus (HBV), caused by Mycobacterium bacteria and hepatitis B virus, respectively, pose serious threats worldwide. This paper examines the spread of these diseases using a mathematical model that incorporates control measures, including vaccination and awareness programs. We use a system of differential equations with control variables and apply Pontryagin's principle to determine optimal control strategies. The stability of the Disease Free Equilibrium (DFE) has been analysed and demonstrated to be both locally and globally asymptotically stable when the basic reproduction number remains below unity, thereby ensuring disease elimination. Furthermore, the Endemic …

Dynamical Analysis And Optimal Control Of The Mpox Transmission Model With Stratified Susceptibility, Tuhfatul Janan, Fatmawati Fatmawati, Cicik Alfiniyah, Santi Martini, Dipo Aldila, Agus Hasan

Mathematical Modelling and Numerical Simulation with Applications

This study develops a mathematical model of Mpox transmission that combines stratified susceptibility (low-risk and high-risk groups) with vaccinated and asymptomatically infected compartments. The analysis of the model begins with examining the well-posedness, boundedness, and nonnegativity conditions for the solutions. The local stabilities of the equilibria are examined through the Jacobian matrix and phase plane analysis, while the global stabilities are provided through Lyapunov functions. The estimated parameters are verified using epidemiological data on Mpox cases in the United States, with an MAPE of 2.20% and R_0 > 1, indicating that Mpox remains endemic. Sensitivity analysis indicates that the contact rate …

What Is Alive? Students’ Conceptions Of The Traits That Unite Living Organisms, Jeremy L. Hsu, Meredith A. Dorner, Kate Hill

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

Biology is the study of life, but students often hold misconceptions about what it means to be alive, with children often associating life with movement. These misconceptions can lead to biases in what students think is alive, with younger children often not thinking of plants as living given their lack of discernable movement. Despite this past work, there have been no prior studies that we are aware of that have examined how students in introductory biology conceptualize what it means to be alive. Here, we draw upon a fortuitous dataset collected from an in-class activity done on the first day …

Numerical Simulations And Hyers-Ulam Stability Of A Novel Nonlocal Anthropogenic Cutaneous Leishmaniasis Mathematical Model, Khalid Fanoukh Al Oweidi, Zakirullah -, Kamal Shah, Thabet Abdeljawad

Mathematical Modelling and Numerical Simulation with Applications

In this work, the fractal-fractional Atangana-Baleanu derivative with the Mittag-Leffler kernel is employed to capture the memory and hereditary effects inherent to anthropogenic cutaneous leishmaniasis transmission dynamics. The Banach fixed-point theorem and contraction mapping principle are used to prove the existence and uniqueness of solutions, while Hyers-Ulam stability of the system is analyzed to demonstrate the robustness of solutions with respect to small perturbations. Using a nonlinear least-squares approach, model parameters and fractional order are estimated using epidemiological data from the World Health Organization. The basic reproduction number $R_0 = 0.53$ indicates that the disease is under control after adding …

Optimal Control And Bifurcation Analysis Of A Predator–Prey Model With Self-Limiting Growth And Predator Disease, Dipo Aldila, Muhammad Akmal Fasya, Bevina D. Handari, Chidozie Williams Chukwu, Olumuyiwa James Peter

Mathematical Modelling and Numerical Simulation with Applications

We propose and analyze an eco-epidemiological predator–prey model that incorporates self-limitation and disease transmission within the predator population. The model is formulated as a system of ordinary differential equations describing logistic prey growth under the interspecific interaction with the predator. On the other hand, the predator population is divided into susceptible and infected classes, whose growth is constrained by prey availability. Three biologically relevant equilibria are identified: predator extinction, disease-free coexistence, and coexistence with endemic disease. The existence and stability of these equilibria are determined by key ecological and epidemiological thresholds, including the basic reproduction number. Using numerical continuation methods, …

Preferences For Mathematics And Science Education Majors Among Senior High School Students In Bataan, Zydrick L. Avelino

Jurnal Pendidikan Sains

This study examines the factors influencing Senior High School students’ preferences for Bachelor of Secondary Education (BSEd) majors in Bagac and Morong, Bataan, with particular focus on the low interest in Mathematics and Science specializations despite increasing demand for STEM educators. Using a descriptive quantitative design, data were collected from 369 students through a structured survey and analyzed using frequency and percentage distributions. The results reveal a strong preference for non-STEM majors, with Social Studies (42.12%) and English (35.04%) dominating, while Science (15.43%) and Mathematics (7.395%) received significantly lower interest. Personal interest emerged as the primary determinant (58.8%), followed by …

Morphological Characteristics Of The Mediophyceae Diatom Lampriscus Cf. Shadboltianus Var. Crenulatus Collected From Gili Meno, Indonesia, Arief Rachman, Riani Widiarti, Setiarti Sukotjo, Mark Wells

Makara Journal of Science

Diatoms are the most common and abundant microalgae group in seawater, with an estimated 200 genera and 200,000 species categorized into three distinct taxonomic classes: Mediophyceae, Bacillariophyceae, and Coscinodiscophyceae. This study describes the morphological characteristics of Lampriscus GM052022, a diatom belonging to the Mediophyceae family, which was collected from Gili Matra, Lombok, Indonesia. Analysis using light microscopy (LM) and electron microscopy (EM) showed that the morphological characteristics of the Lampriscus GM052022 specimen are similar to those of Lampriscus shadboltianus var. crenulatus due to the distinct crenulation lines on the frustule, which differentiate this variation from Lampriscus shadboltianus. However, the …

Design And In Silico Modeling Of Heterocyclic-Based Xanthone Derivatives As Potential Anticancer Agents Through Tyrosine Kinase Inhibition, Yehezkiel Steven Kurniawan, Ervan Yudha, Nela Fatmasari, Radite Yogaswara, Harno Dwi Pranowo, Eti Nurwening Sholikhah, Jumina Jumina

Makara Journal of Science

Cancer is one of the deadliest diseases nowadays, and tyrosine kinase receptors play crucial roles in cancer cell survival, differentiation, proliferation, and migration. This study designed and developed a new inhibitor from heterocyclic-based xanthone derivatives to target two tyrosine kinase receptors, epidermal growth factor receptor (EGFR) and platelet-derived growth factor receptor (PDGFR), through in silico screening. Eighteen heterocyclic-based xanthones were evaluated through molecular docking for both receptors. All heterocyclic-based xanthones gave the root mean square deviation (RMSD) value lower than 2.00 Å. Xanthone with isobenzothiazole substituent (iBzThio) was found as the most potent inhibitor with binding energies of -10.60 and …

Liparis Condylobulbon Reichb. F. From Gumitir, Indonesia: Morphology, Molecular, And Phytochemical Profile, Fuad Bahrul Ulum, Asyifa Yasmin Arum, Kurnia Sa’Adah, Dwi Setyati, Edia Fitria Dwinianti, Ranjithkumar Rajamani, Ari Satia Nugraha, Mukhamad Su’Udi

Makara Journal of Science

Liparis condylobulbon Rchb.f. is an epiphytic orchid across South and Southeast Asia, which holds notable ethnomedicinal and pharmacological significance. This study aims to characterize Indonesian Liparis condylobulbon using integrated morphological, molecular (matK, rbcL, ITS2), and phytochemical (LC-MS, DPPH) analyses of specimens from Mount Gumitir, providing the first comprehensive taxonomic and pharmacological profile to support species authentication and future bioprospecting. The L. condylobulbon specimen displays diagnostic epiphytic morpho-logy, including fusiform pseudobulbs, two elongate leaves, and an erect inflorescence bearing ~123 flowers. Molecular barcoding using matK, rbcL, and ITS2 confirmed its identity, with phylogenetic analyses consistently clustering it with …

Multiplex Functional Assessment Of Variant Effect In The Retinal Transcription Factor Crx, James Lewis Shepherdson

Arts & Sciences Graduate Student Theses and Dissertations

The transcription factor Cone-Rod Homeobox (CRX) is a master regulator of photoreceptor cell fate. Sequence variants in CRX can cause Retinitis Pigmentosa, Cone-Rod Dystrophy, and Leber Congenital Amaurosis, all inherited causes of vision loss and blindness. CRX is the only gene implicated in the pathogenesis of all three of these diseases, which present with both rod- and cone-centric phenotypes of varying age of onset and severity. Several CRX variants have been reported to cause severe dominant disease through antimorphic genetic interactions with wild-type CRX, and yet these mutations are adjacent to variants which are benign or only cause mild, recessive …