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Hedysarum Mongolicum Turcz.: An Important Protein Resource Legume On Dry Sandy Land, Li Min, A W. Hovin

IGC Proceedings (1977-2023)

In searching for plants that can both increase the protein production and improve the sandy-soil conservation of the grassland in the arid, windy regions of North China, so far, from among many native plants, we have identified Hedysarum mongolicum Turcz. as the best species to fulfill our dual purposes. We investigated its distribution, planted its native seeds in the Maowusu desert, and studied it under its native and cultivated growing conditions from 1957 to 1964. Chinese farmers call this perennial subbrush legume of the sweetvetcb genus "Yang Cai," meaning "sheep like to eat." It can thrive in the stable or …

Adaptation And Utilization Of Three Legume In China, Huang Wenhui

IGC Proceedings (1977-2023)

China is a vast territory with extremely varied climates, soil, and topography, and it is very rich in pasture grass resources. The main legumes for forage are Alfalfa (Medicago sativa L.), yellow alfalfa (Medicago folcata L.) and shadawang (Astragalis adsurgent Pall.)

Preliminary Evaluation Of Legume Germ Plasm In The Cerrados Of Brazil, D Thomas, R P. De Andrade

IGC Proceedings (1977-2023)

In 1978 an evaluation program was initiated to select legumes that (1) grow and produce seed on acid soils under aluminum and water stress, (2) persist under grazing, and (3) tolerate pests and diseases. The work is being conducted at the Cerrados Agricultural Research Center, near Brasilia, at lat 15°S and altitude 1,000 to 1, 100 m . Annual rainfall is 1,500 mm, mostly distributed in a 6-month wet season, and mean annual temperature is 21°C. Nine hundred legume accessions from thirteen genera have now been established as spaced plants on the 2 major soil types of the region. The …

Genetics And Utilization Of Apomixis For The Improvement Of Guineagrass (Panicum Maximum Jacq.), Y H. Savidan

IGC Proceedings (1977-2023)

Natural polymorphism in guineagrass (Panicum maximumjacq.) has been stabilized in tetraploid biotypes by apomixis. Sex­ual diploids were found in East African populations. Our objective was to determine whether apomixis could be related with a simple genetic background and manipulated in an improvement program. Apomicts of guineagrass are characterized by a 4-nucleate embryo sac structure, and this trait was used in genetical analyses to differentiate apomictic from sexual hybrids. Progeny tests were also conducted as controls. Ten different types of progenies were analyzed: tetraploid sexual (from colchicine treatment of diploids) x apomictic F1 hybrids; selfed and backcrossed progenies of sexual F1 …

Breeding Challenges In Apomictic Warm-Season Grasses, E C. Bashaw, P W. Voigt, B L. Burson

IGC Proceedings (1977-2023)

Efforts to breed apomictic grasses met with little success in the past, but results of more recent research show significant progress with some species and new prospects for improving apomicts. Early research uncovered the cytological basis for apospory and diplospory, found the common apomictic mechanisms in grasses, and showed that apomixis is transmitted from pannt to offspring. Discovery of sexual or partially sexual (facultative apomicts) plants in several species formerly considered obligate apomicts allowed for hybridization and genetic studies. Results of subsequent research confirmed inheritance of apomixis, and data from the more conclusive studies indicate that method of reproduction …

Visualizing Ozone Pollution In The Denver Metro Area Using A Bioindicator Garden, Ella K. Mathews, Hillary Hamann, Julie Morris, Erica L. Larson

DU Undergraduate Research Journal Archive

Since the industrial revolution, widespread fossil fuel combustion has significantly increased atmospheric pollution. The combustion of fossil fuels releases nitrogen oxides (NOx) and volatile organic compounds (VOCs), which form tropospheric (ground-level) ozone when exposed to sunlight. Ozone directly harms plants by disrupting their ability to absorb carbon dioxide, release oxygen, and carry out photosynthesis. Bioindicator species are plants that have visible responses to environmental conditions, such as ozone, and can act as “canaries in the coal mine,” indicating the health of their environment. In this study, we used a garden of ozone bioindicator species (ozone garden) as a cost-effective tool …

Du Undergraduate Showcase Abstracts: Research, Scholarship, And Creative Works, Sophia Wismar, Henry Staats, Allison Metzler, Chloe Puckett, Rachel Levine, Christa Kilpatrick, Scott Wolf, Joe Walsh, Grace Doolittle, John Engebreston, Zoe Lopez, Christopher Aaby, Audrey Duff, Timothy Sisk, Katelyn Lamberton, Angela Narayan, Gilkah Argueta, Habiba Samir, Girena Tesfazghi, Genet Kenore, Sinit Tesfamariam, Effley Brooks, Abi Newell, Megan Doherty, Natalie Baer, Lexi Blood, Talya Riciputi, Jessica Jimenez, Devin Hernandez, Lynn Clark, Taj Kumar, Sunil Kumar, Allen Rutman, Mira Pronobis, Tess Carson, Anna Sher, Frankie Stroud, Tamra Pearson D'Estree, Alyssa Wilson, Emily Melnick, Jenalee Doom, Yihang Gao, Gwendolyn Geiger, Noah Gettle, Scott Nichols, Clare Ayoub, Cara Dienno, Sunny Walker, Zoe Hansen, Maya Wheeler, Addison Rice, Patrick Martin, Sanjana Acharya, Daniel Mcintosh, Amanda Mckellips, Calli Cain, Justin Blake, Peter Sokol-Hessner, Natalie Miller, Max Weisbuch, Sophia Dellota, John Macikas, Charlotte Snow, Mark Siemens, Zoe Lynch, Alex Huffman, Prachi Shah, Jason Roney, Halcyon Levi, Nicole Herzog, Andrea Koly, Daniel Linseman, Annie London, Xi Yang, Avery Zwisler, Jane Smith, Chaz Contag, Michael Kerwin, Lucy Rand, Grace Schroeder, Michelle Rozenman, Nissa Tapper, Guiming Zhang, Mateo Mazariego-Halpern, Keith Meyer, Julie Do, Dakota Park-Ozee, Travis Herink, Kara Neu, Jonathan Plomin, Eve-Odine Duchaufour, Debbie Gale Mitchell, Tennyson Anderson-Stricklin, Lily Treitz, Samantha Rosenberger, Sierra Griffith, Finley Joseph, Daniel Sampson, Emmy Davis, Skyler Kasnoff, Evon Lopez, Vivian Nguyen, Cassy Young, Franklin Sellner, Martin Tobon, Ila Graham, Zach Billings, Holden Hedit, Decatur Boland, Paul Kosempel, Cory Chandler, Jay Mahoney, Sam Dragan, Susan Dagget, Yarrow Ator, Heidi Vuletich, Owen Weber, Andrew Kloeppel, Petersen Gray, Mandi Schaeffer-Fry, Razleen Bassra, Bryanna Rodriguez, Christina Blue, Taubie Sanders, Rachel Epstein, Luke Milburn, Camryn Evans, Ezra Martinez, Mary Westwood, Gabri Notov, Robin Tinghitella, Lilou Cabrol, Eli Barbour, Juliet Mendik, Selma Myers, Zac Wise, Noah Fahlin, Michelle Knowles, Abigail Hopper, Michael Greenberger, Romi Laclair, Sarah Watamura, Sabrina Efroymson, Casey Barker, Sydney Seltzer, Bryn Yehle, Jennifer Hoffman, Sara Garcia, Ryuka Nagamine, Trevor Briggs, Remy Le Boeuf, Elena Krone, Eileen Farrell, Regan O'Rourke, Elena Roel, Greg Mortimer, Ali Ayoub, Stefani Langehennig, Caitlin Turk, Logan Scmid, Stefan Chavez-Norgaard, Karen Kim, Tatiana Peccedi, Courtney Cassidy, John Sebesta, Rhianna Lewis, Janice Bening-Lacek, Vivian Lawless, Mckenna Hanson, Jeffrey Amidon, Riya Joshi, Ram Ambre, Brady Worrell, Perrin Schneider, Ali Azadani, Brooke Agulnek, Lyndsie Salvagio, Elise Siemanowki, Yan Qin, Andre Allen, Melodie Nguyen, Megan Livengood, Abby Reams, Saffron Hartreeve, Bri Wylie, Sarah Brookman, Mariah Loiacono, Green Russo, Abhia Lodhi, Gabrielle Welsh, Nika Spehar, Shahked Levin, Evrim Baykal, Kimberly Chiew, Jocelyn Torres, Kailey Hicks, Mykaela Tanino-Springsteen, Audrey Bellows, Akam Chahal, Madeline Tepper, Shannon Murphy, Alexa Fonseca, Deborah Han, Cassandra Perez, Oluwatoyin Alaba, Julia Roncoroni, Vy Nguyen, Nana Burn, Sarah Sasse, Rubin Tuder, Anthony Gerber, Nancy Lorenzon, Christine Vohwinkel, Camryn Gunter, Tristan Weber, Sam Rommel, Brian Michel, Muskan Fatima, Alannah Oleson, Kira Frey, Edward Garrido, Beckett Morris, Kerstin Haring, Drew Middleton, Abigail Walpert, Liam Dee, Gabby Ishaw, Cole Carnes, Maddie Weiser, Claire Fox, Valeriia Vlasenko, Kateri Mcrae, Riley Smith, Abigail Templin, Kushani Rajapaksha

DU Undergraduate Research Journal Archive

Abstracts from the DU Undergraduate Research Showcase.

Phenotypic Plasticity In A Stochastic Environment: Modeling Three Phenotypes And Environments, Sarah P. Williams, Marissa C. K. Douglas, Stephen C. Adolph

Spora: A Journal of Biomathematics

Phenotypically plastic organisms are capable of adjusting their phenotypes in a variable environment. Padilla and Adolph (1996) modeled this process and included a time lag between detection of an environmental change and the responding change in phenotype. We extended the Padilla and Adolph model from two to three discrete environments and phenotypes and analyzed the model computationally. Our results were consistent with their findings: the fitness advantage of phenotypic plasticity is higher when (1) the lag time is shorter, (2) the probability of environmental change is lower, and (3) the fitness disadvantage of mismatched phenotypes and environments is more severe. …

Long Panel Studies Of Small-Scale Rural Societies In The Global South: What Is Their Value, Why Are They Rare, And Suggestions To Make Them Happen, Jonathan Bauchet, Ricardo Godoy, William R. Leonard, Victoria Reyes-Garcia, Asher Y. Rosinger, Susan Tanner, Eduardo A. Undurraga

Department of Agricultural Economics Faculty Publications

Many topics in the behavioral sciences and epidemiology require researchers to directly observe entities (e.g., individuals, households) over a long time to identify lasting effects. Long-term panel data collection is more common in high-income countries than in small-scale rural societies (SSRS) of low-income countries. SSRS are mobile, nature-dependent, linguistic minorities, and highly autarkic. Analyzing such data using a life-course perspective can help uncover patterns that align or upend what we know from high-income countries. This study a) reviews long (>∼10 year) panels in SSRS (n = 9), b) extends the analysis to cover somewhat comparable societies of smallholders (n …

Evaluating Soil Health And Crop Yield In Louisiana Agricultural Systems: Impacts Of Best Management Practices And Prediction Models, Hector J. Mendoza Lagos

LSU Doctoral Dissertations

The adoption of conservation management practices is critical for improving soil health, enhancing nutrient use efficiency, and sustaining crop productivity in row crop systems in Louisiana. This study evaluated the role of conservation agronomic practices, soil biochemical indicators, and machine learning predictive models to improve soil nutrient dynamics, soil health indicators, microbial communities (MC), and crop productivity on a corn (Zea mays L.) research plot scale and in a commercial forty-hectare cotton (Gassypium hirsutum L.)-corn-soybean (Glycine max L.) rotation system in northeast Louisiana. The objectives of the study were to evaluate soil nutrient dynamics and MCs under …

Host Range And Characterization Of Phytophthora Species That Cause Plant Diseases In California, Dinh Hieu Pham

Natural Sciences and Mathematics | Biological Sciences Master's Theses

Phytophthora is one of the most destructive genera of plant pathogens in California, posing significant threats to both nursery production and natural ecosystems. Phytophthora ramorum, the causal agent of Sudden Oak Death (SOD), has expanded its host range to include more than 100 plant species. In addition, Phytophthora elongata, previously isolated in Western Australia from Eucalyptus marginata in 2013, has recently been detected for the first time in the United States on Rhododendron species. This naturally raises concern that a new etiological species has entered the country. Therefore, the goal of this thesis study was three-fold:  i) to …

Hepatoprotective Evaluation Of Benzoylated Emodin Derivatives: Integrating Bioinformatics And In Vitro Studies, Firdayani Firdayani, Putri Hawa Syaifie, Siska Andrina Kusumastuti, Muthia Rahayu Iresha, Wirawan Adikusuma, Dhecella Winy Cintya Ningrum, Etik Mardliyati, Ayu Masyita, Ariza Yandwiputra Besari, Fathir Azzaki Iradata, Lucy Arianie

BioMedicine

Background: Emodin exhibits various pharmacological activities, including hepatoprotective effects. However, its clinical application is limited by poor absorption and low oral bioavailability. This study aimed to optimize emodin through benzoylation and to assess the hepatoprotective potential of the resulting derivatives integrating bioinformatics and in vitro methods.

Methods: We conducted network pharmacology, molecular docking and molecular dynamics (MD) simulations to predict potential targets and interactions of benzoylated emodin derivatives. The derivatives were synthesized and evaluated for cytotoxicity using the MTT assay. The hepatoprotective effects were assessed in vitro using a paracetamol-induced HepG2 cell injury model.

Results: Network pharmacology analysis and gene …

High-Throughput Robotic Ethanol Inhibition Assays For Engineered Thermophilic Biofuel Strains, Kevin He, Daniel Olson, Marybeth Maloney, Anthony Lanahan

Wetterhahn Science Symposium Posters

Ethanol stress assays are commonly used to evaluate microbial tolerance, metabolic adaptation, and fermentation performance. However, manual liquid handling introduces variability across replicate wells and small-volume pipetting steps, limiting reproducibility and throughput. This study developed an automated OT-2 robotic workflow to generate replicated ethanol concentration gradients for high-throughput inhibition assays in engineered thermophilic biofuel strains. Kinetic plate-reader measurements were used to quantify ethanol-dependent growth responses under anaerobic fermentation conditions. The reasearch question is: How do engineered thermophilic biofuel strains differ in ethanol-dependent growth inhibition under anaerobic fermentation conditions, and can automated robotic assays improve the reproducibility of these measurements? Can …

Rethinking Functional Groupings In Basketball Wings Through Ecological Trait Frameworks, Dhruv Mehrotra

Theses and Dissertations

This paper starts with a review about Plant Functional Types and then goes deeper into the conceptual foundations of Plant Functional Types (PFT's) with detailed discussion of global trait spectra such as the leaf economics spectrum and the fast-slow continuum. Using concepts like response and effect traits, the review then talks about how a trait based ecological framework can provide a more robust guideline to classify plants. The review then talks about how players in basketball have been classified in the past along with some of the newer typologies. The review starts to draw some parallels between the ecological framework …

Oregon State Rank Assessment For Straggling Gilia (Allophyllum Gilioides), Lindsey K. Wise

Institute for Natural Resources Publications

Oregon state conservation status assessment for Straggling gilia (Allophyllum gilioides) using NatureServe methodology, 2026.

Wake-On-Anomaly Federated Architecture For Privacy-Preserving Poultry Health Early Warning, Mahmoud Aziz Louati

Masters Theses

Highly pathogenic avian influenza outbreaks, respiratory disease, heat stress, and silent equipment failures share one operational reality: they are detected too late because today’s poultry-health workflow is reactive, manual, and dependent on producers volunteering commercially sensitive data. This thesis presents a wake-on-anomaly federated architecture that addresses both the detection-latency problem and the privacy–adoption deadlock that has so far prevented cross-farm collaboration. The architecture is organized in two tiers. Tier 1 is a lightweight LSTM autoencoder that continuously screens four routine telemetry channels (water, feed, house temperature, activity proxy) and emits a per-window reconstruction-error score. A debounced k-of-m trigger with cooldown …

Popgenhelpr: An R Package To Streamline And Facilitate Informed Population Genomic Analyses And Visualization Of Genetic Ancestry, Diversity And Differentiation, Keaka Farleigh, Mason O. Murphy, Christopher Marie Blair, Tereza Jezkova

Publications and Research

Analysing large population genomic datasets requires an interdisciplinary skillset. Beyond a knowledge base in genetics and population biology, population genomic analyses involve computer science and statistics, representing a barrier for researchers without experience in those fields. PopGenHelpR seeks to lower this barrier by enabling researchers to perform population genomic analyses and generate near-publication quality figures in a streamlined and informed fashion. PopGenHelpR allows users to estimate genetic diversity within populations as well as differentiation among populations and individuals from single nucleotide polymorphism data. PopGenHelpR includes commonly used measures such as observed heterozygosity and FST. PopGenHelpR also provides five …

Phytochemical Composition And Bioactivities Of Roselle (Hibiscus Sabdariffa L.) Extracts Obtained By Infusion, Ethanolic Maceration, And Maltodextrin-Assisted Drying, Risna Silvianti, Warsito Warsito, Elok Zubaidah, Zubaidah Ningsih, Aqidatul Izza

Karbala International Journal of Modern Science

Roselle (Hibiscus sabdariffa L.) is rich in phenolic compounds and anthocyanins, but the extraction method may influence its chemical composition and biological activity. This study compared hot-water infusion, ethanolic maceration, and maltodextrin-assisted drying. It aimed to examine the relationship between the extraction method, chemical profile, and bioactivity. The resulting extracts (EI, EM, and EP) were analyzed for total phenolic, flavonoid, and anthocyanin, LC-HRMS profiles, and antioxidant capacity by the FRAP assay. Antibacterial analysis was conducted against Escherichia coli (ATCC 25922) and Staphylococcus aureus (ATCC 25923) using agar well diffusion. Cytotoxicity tests (MTT, 24 h) were performed against HT-29, 4T1, …

Effects Of Warming On Growth And Leaf Colonization By Litter Mat-Forming Fungi In A Wet Tropical Forest In Puerto Rico, Ari E. Puentes, D. Jean Lodge, Deyaneira A. Ortiz-Iglesias, Tatiana Barreto-Vélez, Laura C. Rubio-Lebrón, Hieu Chu, Christine S. O'Connell, Sasha C. Reed, Tana E. Wood

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

Wet tropical forests are experiencing rising temperatures and increased frequency and intensity of extreme climatic events, such as cyclones, which can increase rates of soil erosion and surface runoff. Fungal litter mats, formed by agaric decomposer fungi, play a crucial role in stabilizing slopes, preventing erosion, and aiding nutrient cycling; however, little is known about how warming affects litter mat growth and function. We investigated two litter mat-forming fungi, Gymnopus johnstonii and Marasmius aff. crinis-equi, in warmed (+4°C above ambient) and control plots in the Luquillo Experimental Forest, Puerto Rico. Growth and time-to-leaf colonization were monitored over 6 weeks …

Lowland Tropical Forests Remain A Methane Sink Under Warming And Long-Term Hurricane Disturbance Recovery, Gabriele Larocca Conte, Lucia Zuvela, Rachel Cruz-Pérez, Tatiana Barreto-Vélez, Nibia Becerra-Santillan, Sophia F. Campbell, Hieu P. Chu, Trung Dam, Iana F. Grullón-Penkova, Miriam Kleit, Deyaneira A. Ortiz-Iglesias, Laura C. Rubio-Lebrón, Molly A. Cavaleri, Sasha C. Reed, Debjani Sihi, Tana E. Wood, Christine S. O'Connell

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

Methane (CH₄) is a potent greenhouse gas, and tropical forests account for roughly one–third of global atmospheric CH₄ uptake by soils. Projected warming and more frequent hurricanes in these ecosystems may alter soil CH₄ sink strength, as warmer and wetter soils enhance methanogenesis activity. We measured soil CH₄ and CO₂ efflux during the calendar summer months of 2023 and 2024 alongside continuous records of soil moisture, soil and air temperature, and precipitation in an in–situ warming experiment (TRACE) located in a lowland tropical forest in Puerto Rico, six to seven years after Hurricanes Irma …

Deforestation Dynamics In The Amazon: Impacts, Socio-Environmental Drivers And Restoration Pathways, Maria Natalia Rodriguez

Master's Projects and Capstones

The Amazon, which is the largest tropical rainforest in the world, experienced 542,581 km² of forest loss between the years 2000 and 2020. The process of deforestation endangers the ecological system results which maintain ecosystem connectivity and the Earth's climate system. The Amazon rainforest supplies essential ecological services which include maintaining soil fertility, storing carbon, purifying water and climate stability. The fundamental ecosystem of this area faces new threats because of increasing forest destruction. The research study adopts a combined methodology that uses Geographic Information Systems (GIS) with a comprehensive literature review to study Amazon deforestation patterns and its driving …

Replication And Architectural Enhancement Of Omni Aggregation Networks, Matteo Calviello

Rose-Hulman Undergraduate Research Publications

Single Image Super-Resolution (SISR) reconstructs high-resolution images from low-resolution inputs, a capability valuable across many application domains. This thesis focuses on the replication and architectural enhancement of the Omni Aggregation Network (OAN), a lightweight super-resolution architecture designed to balance reconstruction quality with computational efficiency through a novel omni-axis self-attention mechanism.

Independent replication remains a persistent challenge in machine learning research, and this work addresses that issue directly. Initial replication attempts trailed the original reported results by approximately 6-10% in performance metrics before several undocumented implementation details were identified. After correcting these discrepancies, the replicated implementation achieved results within 4% of …

Somatic Prosthetics For Planetary Resonance, Disha Dharesh Kumar R

Masters Theses

This thesis investigates how industrial design can transcend extractive technological paradigms in favor of relational interfaces that foster planetary attunement. Framing the climate crisis as a 'crisis of imagination', the research challenges the Western bifurcation of nature and culture by drawing on Indic cosmologies- which recognize stones, plants, and ecosystems as conscious at different levels and participants in a shared cosmic field. By synthesizing research in Biosemiotics, Quantum Information Pansycishm, and Neuroscience, the project redefines intelligence as a distributed, more-than-human phenomenon.

The research materializes as a speculative design artifact: a device that functions as a somatic prosthetic for planetary resonance. …

Environmental Mercury Alters Immune Pathways Linked To Autoimmune Risk In Mice Mirroring Humans, Maurgan Lee, Paul Stemmer, Randall Gill, Allen Rosenspire, Anil Aranha, Heather Gibson

Medical Student Research Symposium

Background and Purpose: Mercury is a pervasive environmental contaminant, and human epidemiologic studies have linked chronic low-level exposure to increased autoimmune disease-risk. Dysregulated lymphocyte activation and impaired signaling tolerance are central mechanisms in human autoimmunity. Protein phosphorylation governs lymphocyte differentiation and function, alterations in phosphoproteomic networks may represent a signature of immune disruption. This study evaluates how low dose mercury exposure modifies B and T cell abundance and intracellular signaling patterns in BALB/c and Diversity Outbred (DO) mice.

Methods: BALB/c and DO mice were exposed to low dose HgCl2 in their water for two weeks or provided standard water controls. …

Beyond Stabilization: Biological Healing, Structural Exclusion, And The Recovery Gap After Border-Fall Trauma At The U.S.-Mexico Border, Julia Robinson

Undergraduate Honors Theses

This honors thesis examines the biochemical, ethical, and public health consequences of insufficient post-operative follow-up care for undocumented immigrants injured in border falls. Discussing pathways of inflammation resolution, wound healing, and bone remodeling, this thesis argues that recovery depends on tightly regulated molecular and cellular processes that are highly vulnerable to disruption without continued monitoring and rehabilitation (Loi et al., 2016; Maruyama et al., 2020). When follow-up care is absent, these processes can be predicted to derail, leading to infection, impaired healing, and permanent disability (Chung & Sohn, 2025; Howard et al., 2020; Kruidenier et al., 2018). Framed through principles …

Do Cover Crops Influence Beneficial And Herbivorous Arthropod Communities Across Growing Seasons?, Adegboyega Fajemisin, Satinderpal Kaur, Alejandro Vasquez, Alexis Racelis, Rupesh R. Kariyat

School of Earth, Environmental, & Marine Sciences Faculty Publications

Cover crops provide multiple ecosystem services in agriculture, yet their influence on arthropod communities remains poorly understood, especially in commercial farming. Despite their potential benefits, it remains unexplored how cover crops affect arthropod community dynamics across multiple growing seasons. We conducted a two-year study across three commercial farms in the Lower Rio Grande Valley, Texas, to examine how cover crops influence arthropod community composition and abundance, whether beneficial arthropods (natural enemies and pollinators) persist into cash-crop phases, and how cover crops affect natural enemy–herbivore relationships. We compared arthropod communities between cover-crop treatments and control plots and tracked responses through subsequent …

Enhanced No₂ Gas Sensing Using Silver-Doped Cadmium Telluride Nanocrystalline Thin Films, Tunis Balasim Hassan

Karbala International Journal of Modern Science

Nitrogen dioxide (NO₂) is a toxic pollutant that necessitates sensitive and reliable monitoring systems. Conventional gas sensors often lack adequate responsiveness and fast recovery under changing conditions and therefore create a need for semiconductors with enhanced performance, especially at high industrial temperatures (around 250 °C). The study therefore aims to synthesis and evaluate silver-doped cadmium telluride (Ag:CdTe) thin films as NO₂ gas sensors. Pure CdTe and Ag:CdTe with silver concentrations of 5, 10, and 15 wt% were prepared by a co-precipitation process. XRD verified cubic symmetry with a progressive fall in crystallite size (6.67 nm to 5.46 nm at 15 …

The Heterogeneous Response Of Astrocytes In Different Brain Regions Under Metabolic Stress, Pawan Kumar Thapaliya

USF Tampa Graduate Theses and Dissertations

Astrocytes play a central role in maintaining ionic homeostasis, neurotransmitter clearance, and brain en-ergy metabolism. Their excitability, reflected in activity-evoked intracellular sodium (Na+, [Na+]i) and calcium (Ca2+,[Ca+]i) dynamics, is increasingly recognized as a critical determinant of neuronal function and vulnerability, particularly under metabolic stress. Despite their importance, the mechanisms underlying astrocytic ionic signaling and its regional heterogeneity remain incompletely understood. In this thesis, I developed detailed computational and biophysical models to investigate astrocytic Na+ and Ca2+ dynamics, their bioenergetic consequences, and the roles of key ion transporters under physiological and metabolically stressed conditions, validating the models against experi- mental data. …

Microtubules In Breast Cancer: Exploring The Α/Β-Tubulin Toggle Switch And Its Implications In Human Breast Cancer, Annemarie Ianos

Student Theses and Dissertations

Microtubules, composed of a/b-tubulin heterodimers, play a central role in breast cancer tumor growth by polymerizing, leading to metastasis and depolymerizing, contributing to proliferation. Human enzymes protein kinase Ca (PKC-a) and cyclin-dependent kinase 1 (Cdk-1) mediate phosphorylation at sites a:Ser165 and b:Ser172, respectively, influencing the growth of microtubules. It is possible that alternating phosphorylation at these sites contribute to an a/b-tubulin “toggle switch” that mediates microtubule instability and tumor growth.

The project investigates the influence of the toggle switch model on microtubule stability by determining the impact of mutants (a:S165D, a:S165N, a:S165S_P, b:S172S_P and a:S165S_P/b:S172S …

Computational Design Of Peptides And Proteins Through Machine Learning Approaches, Emily J. Hendrix

Chemistry and Chemical Biology ETDs

Advancements in machine learning have emerged as a pivotal tool in computational biochemistry, offering new advancements to address challenges in protein structure and function. However, current machine-learning approaches offer limited insight in understanding protein dynamics. The purpose of this work is to combine traditional physics-based computational tools, such as molecular dynamics and coarse-grained simulations, with recently developed AI-driven computational tools to bridge gaps and advance the understanding of proteins in both structural and dynamic aspects. I investigated several approaches such as (i) traditional physics-based methods to study protein conformation and ensembles; (ii) identifying a peptide inhibitor for the PICK1 PDZ …