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The Gut Microbiome, The Gut-Brain Axis, And College Student Well-Being, Idi Mckay

University Honors Theses

This literature review examines how diet, stress, environmental exposure, and food accessibility may influence college students' mental health and academic performance through the gut microbiome and the Gut-Brain Axis (GBA). Current microbiome research often focuses on early childhood development, clinical disease populations, or older adults, while overlooking college-age students who experience significant social, environmental, and biological transitions. College students frequently face food insecurity, irregular eating patterns, chronic stress, inconsistent sleep schedules, and reduced access to nutrient-dense foods, all of which may influence microbial diversity and overall gut health.

This thesis explores how modern campus environments and lifestyle factors may contribute …

Effect Of Temperature On The Defensive And Predatory Behavior Of The Scorpion Hadrurus Obscurus (Scorpiones: Hadruridae), Zia Nisani, Megan Bennett, Audrey Enriquez, Mel Iniquez, Emilia Martinez Rios, Brooklyn Stone

Euscorpius

Scorpions employ their stinging mechanism both for defense and predation, and being ectothermic, temperature influences their physiology and behavior. As such, we hypothesized that temperature both affects defensive stinging and prey-capture behavior in scorpions. We tested the effects of body temperature on these behaviors in the desert hairy scorpion, Hadrurus obscurus Williams, 1970. In the first experiment, scorpions were placed in temperature-controlled chambers with either high (26-28°C) or low (21- 22°C) temperatures and probed to elicit a defensive sting. We recorded the reaction time and the number of probes needed to elicit a sting. In the second experiment, we observed …

High Mobility Group Motif Proteins’ Role In Fibrosis, Inflammation, And Vascular Injury In Systemic Sclerosis, Fabian A. Mendoza, Sonsoles Piera-Velazquez, Sergio A. Jimenez

Jefferson Institute of Molecular Medicine Papers and Presentations

Systemic Sclerosis (SSc) is an idiopathic systemic autoimmune disease characterized by progressive cutaneous and systemic fibrosis, severe vasculopathy, and multiple humoral and cellular immunological alterations. The pathogenesis of SSc is highly complex and remains incompletely elucidated. The fibrotic process is a crucial component of SSc and is responsible for organ failure and high mortality. Although an increasing understanding of the fibrotic process has enabled the clinical development of antifibrotic therapeutic agents, these agents have limited clinical efficacy. Recently, the potential role of a group of transcription factors containing a High Mobility Group (HMG) motif, in the development and pathological manifestations …

Immune Suppression And Metabolic Reprogramming In Bactrocera Dorsalis Parasitized By Fopius Arisanus, Rehemah Gwokyalya, Jeremy Herren, Thomas Ogao Onchuru, Sahadatou Mama Sambo, Cassandra Purity Ronnie, Ndlela Shepard, Sunday Ekesi, Samira A. Mohamed

All Peer-Reviewed Publications

Abstract – Bactrocera dorsalis is a major horticultural pest. Biocontrol using parasitoids, such as Fopius arisanus, is a sustainable tool for managing this pest. However, the mechanisms enabling the successful parasitism of B. dorsalis are poorly understood. Using transcriptomic profiling, cellular bioassays, and targeted metabolite analyses, we investigated how F. arisanus modulates the immunity and metabolic activity of B. dorsalis to achieve a high parasitism rate. Our results revealed a weak and late encapsulation response of B. dorsalis towards F. arisanus. Additionally, parasitism reduced the number of circulating haemocytes by 35%, lowered constitutive granulocyte counts and inhibited phenoloxidase activity in …

Sequencing Of Chenopodium A-Genome Diploids To Identify Potential Mechanisms Of Speciation: A Preliminary Study, Riley Roser

Theses and Dissertations

The genus Chenopodium is of increasing significance, mainly due to allotetraploid quinoa (C. quinoa Willd.,2x = 4x =36, AABB genome) becoming globally recognized for its high nutritional value and tolerance for stress. Diploid A-genome relatives of quinoa in the Western Hemisphere have shown speciation patterns congruent to adaptive radiation, particularly in the North American continent, where a number inhabit ecological niches while others form mixed populations where they are sympatric. Characterization of the genetic mechanism(s) underlying this rapid speciation, could clarify their potential usefulness for improving quinoa . Previous whole-genome assemblies of AA diploids C. watsonii A. Watson and C. …

Terrestrial Abiotic Synthesis Of Simple Precursor Molecules Starting From Two Approaches: The Universality Of Carbon Reduction, Eloi Camprubi, Ben K.D. Pearce, Martina Preiner

School of Integrative Biological & Chemical Sciences Faculty Publications

To address the chemistry responsible for life’s emergence, we examine the simple chemicals accessible on early Earth and the processes that could have transformed them. We focus on carbon reduction as a process central to the direct precursors of life. Two main approaches for the emergence of life’s building blocks and their associated functions are discussed. One approach investigates chemical routes for forming life’s building blocks via processes that worked differently from those of extant life, referred to as “unrestricted” prebiotic chemistries. The other approach establishes a direct mechanistic connection between prebiotic building blocks and extant biochemistry, referred to as …

Proteomic Evidence Indicates Ultrasound-Assisted Extraction Enhances Recovery Of Membrane-Associated Proteins In Hericium Erinaceus, Tanvir Ahmed, Angéla Juhász, Utpal Bose, Netsanet Shiferaw Terefe, Michelle L. Colgrave

Research outputs 2022 to 2026

Membrane-associated fungal proteins mediate essential functions and contain bioactive proteins with therapeutic potential but are underrepresented in aqueous extracts due to hydrophobicity and lipid associations. Ultrasound-assisted aqueous extraction was applied to Lion’s mane (Hericium erinaceus), and the proteins were fractionated by molecular weight (≥30 kDa, 10–30 kDa, 3–10 kDa). Proteomic profiling using data-dependent (DDA) and data-independent (DIA) mass spectrometry identified 1500 and 1702 proteins, respectively (1% global FDR). Ultrasonication induced surface irregularity and a less compact, heterogeneous microstructure. Topology predictions showed higher proportions of transmembrane and secretory proteins in ultrasonicated fractions. Extraction preserved protein integrity (82% molecular-weight retention, 97% tryptic …

Neuroanatomical And Histological Insights Into Central Nervous System Abnormalities Of A 3-Year-Old With Progressive Encephalopathy, Lennox-Gastaut Syndrome, Micrencephaly, And Infantile Spasms, Haley Nation, Omid B. Rahimi, Rachel Morgan-Armbruster, Andrea R. Gilbert

The Journal of Integrative Physiology

Introduction: This case study presents a comprehensive neuroanatomical and histological analysis of the central nervous system from a 3-year-old donor with a rare complex neurological condition characterized by progressive encephalopathy, Lennox-Gastaut syndrome, micrencephaly, and infantile spasms. Method: This analysis was conducted using a combination of detailed gross dissection and histological examination to assess structural and neuronal abnormalities across multiple brain and spinal cord regions. External and internal analysis of the central nervous system revealed profound developmental and atrophic changes across various brain structures, including absent central sulci, abnormal gyration patterns, and severe cerebellar and cerebral atrophy. Key Findings: Key findings …

Decorin Promotes Nascent Proteoglycan Retention In Cartilage Matrix By Strengthening Collagen Ii-Aggrecan Integration, Thomas Li, Gabriela Canziani, Yuchen Liu, Neil Patel, Biao Han, Mingyue Fan, Annie Porter, Bryan Kwok, Chao Wang, Qing Li, David E. Birk, Renato V. Iozzo, Irwin M. Chaiken, X. Lucas Lu, Robert L. Mauck, Lin Han

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Cartilage extracellular matrix (ECM), a hydrated collagen II-aggrecan composite, undergoes dynamic turnover during both normal homeostasis and disease-associated remodeling. This study elucidates a crucial role for decorin in promoting the retention and stability of nascent aggrecan within this matrix. By applying bio-orthogonal click-labeling, we demonstrate that loss of decorin accelerates the release of nascent aggrecan under both physiological and inflammatory conditions, without affecting its preferential localization to the pericellular matrix. Conversely, supplementation with exogenous decorin mitigates inflammation-induced loss of nascent aggrecan, supporting its potential as a therapeutic target. At the molecular level, decorin exhibits strong binding affinity for aggrecan, and …

Agrivoltaic Shading Reduces Soil Greenhouse Gas Fluxes In A Semi-Arid Vineyard, Marcelo Gomes Da Silva, Rafael M. Almeida, Carine Cocco, Engil Pereira

School of Earth, Environmental, & Marine Sciences Faculty Publications

Agrivoltaic systems are expanding in semi-arid regions, raising questions about how panel driven shading alters soil greenhouse gas exchange. We used automated chambers to measure high frequency soil CO2, N2O, and CH4 fluxes in a newly established vineyard agrivoltaic system in Texas across three shading intensities (0%, 35%, 88%) that represent the light environment beneath panels as shaped by panel tilt and solar trajectory. Shading primarily cooled the soil, reducing mean soil temperature from 35.9 °C (0%) to 32.5 °C (35%) and 30.5 °C (88%), while mean soil water content shifted modestly (0.125, 0.106, and 0.130 m3 m−3, respectively). Over …

Why Communicating Minimum Drawdown Elevations For Lake Powell And Lake Mead Can Mitigate Risks Of Volatile Colorado River Flow., Brittany Fager, David Rosenberg, Erik Porse

Reports

There is consensus across Reclamation’s hydrologic ensembles that volatile Colorado River flow will continue, including annual drops of 6 million acre-feet of natural flow above Lake Powell. This volatility poses risk that water managers cannot respond fast enough with the consequence that Lake Powell and Lake Mead drawdown so they no longer fulfill their Congressionally legislated purposes: deliver water, generate hydropower, protect native fish, or sustain infrastructure. In this post we suggest four reservoir operational strategies to reduce all those risks: (1) Identify Catastrophic Elevations where we lose the ability to operate reservoirs for one or more legislated purposes, (2) …

The Three Sisters And Soil Health (Lesson 1), Mara Johnson, Madhav P. Nepal, Jiyul Chang

iLEARN Teaching Resources

In this lesson, students will begin a week-long unit on soil health that is connected to the chapter The Three Sisters from the book Braiding Sweetgrass by Robin Wall Kimmerer. Students will begin the week by reading the chapter and answering discussion questions, and each subsequent day will build on this introduction with project-based learning activities. This module is designed to bridge traditional Indigenous knowledge with primary scientific inquiry, allowing students to explore soil nutrients, polycultures, and agricultural health in a way they can apply to their own lives and local food sovereignty efforts on the Rosebud Reservation.

Rape Pregnancies And Consequent Ptsd Resulting From The Overturn Of Roe V. Wade, Emma Lindenfelser, Yulia Garaeva, Nenette Nti-Agyemang, Ellen Davis, Anna Kabwa, Alexandra M Calaman

Binghamton University Undergraduate Journal

Prior to the 1973 Roe v. Wade ruling, access to safe legal abortions was limited and often restricted along racial, economic, and geographic lines. Nearly fifty years later, women’s health policy evolved again following the 2022 Dobbs v. Jackson Women’s Health Organization decision overturning Roe v. Wade. This court ruling decimated federal protections of abortion. This paper presents the research that the 2022 Dobbs judicial decision may contribute to and exacerbate rape-related PTSD on 1 out of 20 American who are unable to access a safe abortion after a rape-related pregnancy. Pregnant women living in conservative states that have outlawed …

Exploring The Effects Of Pest-Induced Hemlock Mortality On Growth In Neighboring Trees, Sidney L. Booher

McNair Culminating Research Projects

Trees provide many important products and services to humans. In particular, tree growth is critical to carbon storage, air and water quality, and helps determine demographic processes like population growth and reproductive success. Importantly, tree growth is sensitive to both abiotic (environmental) and biotic factors and is vulnerable to ecological disturbances. Understanding how tree populations respond to disturbances, like invasive pests, is therefore crucial to formulating timely and effective forest management practices.

Here, I used tree ring analysis to investigate how competition for water between neighboring trees changes following the decline of Eastern and Carolina Hemlock(ECH) trees due to the …

Shared Premotor Resources Underlie Dual-Task Interference Between Speech And Balance, Weina Lu, Sasha Lifton Lewis, Zoey Wire, Ingo Helmich

Exercise and Sport Studies: Faculty Publications

Humans frequently speak while standing, potentially engaging overlapping motor-cognitive resources. Dual-task paradigms with increased motor-cognitive demands reliably impair postural control, presumably due to competition for shared neural resources. The premotor cortex is critically involved in balance stabilization and in resolving competing motor plans and is also engaged during processing of action-related language. We therefore hypothesized that a central processing bottleneck emerges in the PMC when speaking and controlling posture simultaneously. Forty-one right-handed healthy adults (25 female, 16 male) maintained an upright stance while either verbally describing or mentally imagining navigation through a visually presented maze from an egocentric or allocentric …

Disease-Causing Mfn2 Mutants Impair Mitochondrial Fission Dynamics By Distinct Drp1 Dysregulation, Daniel Lagos, Pamela R. De Santiago, Nicolás Pérez-Bravo, Benjamín Cartes-Saavedra, Josefa Vial-Brizzi, Diego Troncoso-Chandía, Oliver Podmanicky, Rita Horvath, Verónica Eisner

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Mitochondria undergo fusion and fission. While DRP1 regulates fission, fusion is controlled by OPA1, MFN1, and MFN2. The balance between these processes and the crosstalk between machineries remains poorly understood. MFN2 mutations cause Charcot-Marie-Tooth disease type 2 A (CMT2A), affecting mitochondrial fusion and morphology. However, their role in fission is unclear. Using skin fibroblasts from CMT2A patients (L248H and M376V MFN2 mutations) and wild-type mouse embryonic fibroblasts expressing these variants, we studied how MFN2 mutations impact mitochondrial dynamics beyond fusion. We analyzed mitochondrial morphology and dynamics by live-cell confocal microscopy and tested fusion/fission protein levels, oxygen consumption rate (OCR), extracellular …

Polygenic Risk Scores, Sex, And Socioeconomic Factors As Predictors Of Age Of Onset For Major Depressive Disorder, Kaitlyn M. Nowak

USF Tampa Graduate Theses and Dissertations

Major Depressive Disorder (MDD) is a heterogeneous psychiatric condition influenced by genetic, sociodemographic, and environmental factors, yet the extent to which these factors jointly shape the timing of disease onset remains unclear. This study evaluated the effects of polygenic risk scores (PRS), sex, and socioeconomic status (SES) on age of onset for MDD across two independent cohorts: the Pharmacogenomics Research Network Antidepressant Medication Pharmacogenomics Study (PGRN-AMPS) (N = 486) and the All of Us Research Program (N = 8,014). Analyses were restricted to individuals of European genetic ancestry, and PRS were constructed using both European-ancestry (EA) and multi-ancestry (MA) genome-wide …

Discovery Of Bmi-Associated Gut Microbiome Signatures In The Awi-Gen 2 Cohort, Meriem Yagoubi

Theses and Dissertations

Obesity is increasing across sub-Saharan Africa amid rapid dietary, environmental, and urbanization transitions, yet the gut microbiome features associated with adiposity in African populations remain under-characterized. This study investigated whether species-level gut microbiome composition is associated with body mass index (BMI) in the AWI-Gen 2 cohort, and whether BMI-associated microbial signals remain detectable after accounting for the dominant geographic structure of the microbiome. Gut microbiome community structure and diversity were characterized across 1,665 participants, and differential abundance analysis was used to identify taxa associated with BMI after controlling for study site. Machine learning models were then trained to assess how …

Declination Of Groundwater Potential Zones Of Nashik, Maharashtra Using Geographic Information System With Analytic Hierarchy Process-Fuzzy Techniques, Madhusudhan M. Reddy, Bhogayya G. Naidu, Bharat N. Mulay, Ramanjaneyulu B, Ravi K. Kumar, Mirzi L. Betasolo, Praveen U. Goud, Snehal N. Chaudhari

Mansoura Engineering Journal

Groundwater is a critical resource for agriculture and domestic use in the semi-arid region of Nashik District, Maharashtra, where overexploitation and erratic climatic conditions have led to declining groundwater availability. This study integrates Geographic Information System (GIS) with Analytic Hierarchy Process (AHP) and Fuzzy-AHP techniques to delineate groundwater potential zones (GWPZs) and identify suitable sites for artificial recharge. A total of ten thematic layers drainage density, rainfall, geomorphology, elevation, distance from river, geology, slope, land use/land cover, topographic wetness index (TWI), and curvature were derived from SRTM DEM, Landsat-8, and IMD datasets, representing key controls on groundwater recharge, infiltration, and …

Growing Pains: The Loss Of Plasticity To Extreme Anoxia In Developing Embryos Of Austrofundulus Limnaeus, Patrick Ryan Clouser

Dissertations and Theses

Oxygen plays a pivotal role for most animal life on Earth, so much so that even short exposures to no oxygen, anoxia, can have severe effects on the animal's wellbeing. Conversely, aerobic recovery after anoxic insult can be just as detrimental. Some animals are the exception to this rule and demonstrate survival through anoxia and recovery. There has been a great deal of research around anoxia tolerant animals, but what remains unclear are the genetic underpinnings that determine the anoxia tolerant phenotype. RNA sequencing allows for the quantification of RNA transcripts within a sample, which can indicate if a gene …

Limitations And Alternative Applications Of Carbohydrate Fatty Acid Esters As Food Antimicrobials: A Review, Valeria Rodríguez Monge, Namhyeon Park

Nutrition, Dietetics, and Food Science Student Research

Carbohydrate fatty acid esters (CFAs) are nontoxic food additives with reported antimicrobial activity and growing interest as a potential safer alternative to conventional preservatives. However, their translation into real food systems remains limited. This review examined the main factors that restrict the antimicrobial performance of CFAs in foods and evaluated emerging alternative applications, particularly edible coatings, antibiofilm strategies, and synergistic combinations with other cleaning agents or processing techniques. Overall, the available evidence indicates that the antimicrobial efficacy of CFAs is often reduced in real food matrices compared with in vitro conditions. This loss of activity has been mainly associated with …

Wrack Lines Spring-Summer 2026 Volume Number 1, Margaret Cozens, Johann Heupel, Owen Placido, Paul Salopek, Judy Benson

Wrack Lines

“Building community around the places we love,” is the theme of the Spring-Summer 2026 issue of Wrack Lines magazine. Learn about the work of the Six Lakes Park coalition in Hamden, Riverfront Recapture in Hartford, MyCoast in southeastern Connecticut and the statewide land conservation conference. Additional stories tell about the artistry and mission of photographer-videographer Tomas Koeck, and National Geographic explorer Paul Salopek, who is traveling the world on foot.

Vitamin D–Amp Axis In Host Defense Against Fungal Infections, Nuraly S. Akimbekov, Ilya Digel, Svetlana K. Sakhanova, Kuanysh Tastambek, Dinara K. Sherelkhan, Mohammed S. Razzaque

School of Medicine Publications

Vitamin D–mediated regulation of antimicrobial peptides (AMPs) is an important focus in innate immunology and is aimed at elucidating the role of vitamin D in enhancing antimicrobial defense. AMPs are short protein chains that serve as a first line of defense against invading pathogens, including fungi, bacteria and viruses. Unlike conventional antibiotics, AMPs are produced endogenously and are less likely to induce antimicrobial resistance, making them promising candidates for treating infections caused by drug-resistant pathogens. Studies indicate that optimal vitamin D levels are essential for activating antimicrobial pathways and regulating AMPs that target multiple fungal pathogens. This article summarizes recent …

National Agricultural Library (Nal) Search., Leah Everitt, Sonya Lemke

Publications

SEARCH is the USDA National Agricultural Library (NAL)'s main discovery platform that provides integrated access to the NAL Digital Collections, Special Collections, PubAg and AGRICOLA. NAL SEARCH is a valuable tool for health science librarians, students, and professionals seeking veterinary science, nutrition, or animal experiment alternatives. This article aims to give users a comprehensive overview of this resource.

Nmda Receptor Subunit Nmr-2 Regulates Pathogen-Induced Immune Responses Via The Nervous System In C. Elegans, Benson Otarigho, Jonathan Lalsiamthara, Alejandro Aballay

Faculty, Staff and Student Publications

Neural control of innate immunity must balance restraint of basal immune activity with rapid activation upon pathogen encounter. Glutamate, the primary excitatory neurotransmitter in the nervous system, has been implicated in several neurological disorders associated with inflammation, suggesting a potential link to immune regulation. However, how glutamatergic signaling contributes to immune balance remains unknown. Here, we demonstrated that the NMDA-type ionotropic glutamate receptor subunit NMR-2, a component of the NMDA receptor complex, acts in the

Effects Of L-Baiba Supplementation With And Without Grains Of Paradise On Changes In Resting Metabolic Rate, Body Composition, And Cardiometabolic Risk Factors, Leah E. Allen, Paige J. Sutton, Alex Schrautemeier, Kevin Holley, Connor J. Gaige, Joesi M. Krieger, Anthony M. Hagele, Karenina Antequera Gutierrez, Petey Mumford, Chad Kerksick

Faculty Symposium

To evaluate the impact of 56 days of supplementing with L-BAIBA or L-BAIBA + GOP (BGOP) on resting metabolic rate, body composition, perceptual indicators of mood and affect, and cardiometabolic markers in overweight and obese men and women.

METHODS: Healthy men and women (43.2±11.4 years, 169.4±7.6 cm, 90.3±15.6 kg, 31.4±4.4 kg∙m-2) completed a weekly exercise program and followed a calorierestrictive diet and were randomly assigned in a double-blind and blocked manner according to sex and DXA lean mass to consume daily either a placebo (PLA) (n=12 [11F, 1M]), 500 mg L-BAIBA (L-BAIBA: MitoBurn™, NNB Nutrition) (n=13 [9F, 4M]), or …

First Course Portfolio For Plpt 803 Fundamentals Of Scientific Discovery, Hernan Garcia-Ruiz

UNL Faculty Course Portfolios

PLPT 803 Fundamentals of Scientific discovery is a new curse in the Department of Plant Pathology at the University of Nebraska-Lincoln. I designed and developed this course from the ground up. Initially, it was offered as a special topic (PLPT 892-014) for four years. PLPT 803 was approved by the College of Agricultural Sciences and Natural Resources curriculum committee in September of 2025. PLPT 803 is unique within the University of Nebraska system and will be offered for the first time in the fall of 2027. The course is designed for students to learn fundamental scientific skills such as scrutinize, …

Applications Of Iceye Commercial Satellite Synthetic Aperture Radar In The Laurentian Great Lakes, Ray H. Watkins, Susan Janiszewski, Michael Sayers, Robert Shuchman, Karl Bosse, Gary L. Fahnenstiel, Joseph W. Burns

Michigan Tech Publications

The Laurentian Great Lakes, often resembling inland seas, exhibit complex interactions between wind and waves that influence lake conditions. Monitoring these dynamics currently relies on buoy-based measurements and model predictions. Recent advancements in commercial satellite technology now provide high-revisit, high-resolution Synthetic Aperture Radar (SAR) imagery, such as ICEYE’s X-band data from the NASA Commercial Satellite Data Acquisition (CSDA) program. SAR offers all-weather, day-and-night capabilities, making it a valuable tool for Great Lakes monitoring. In this study, we assess the effectiveness of ICEYE SAR for lake monitoring, focusing on western Lake Erie. We evaluate multiple imaging modes and find that Stripmap …

Life-Stage Specific Predatory Efficiency Of 2 Generalist Predators Of Bemisia Tabaci (Hemiptera: Aleyrodidae), Itohan Aigbedion-Atalor, Abdelmutalab G. Azrag, Alvin M. Simmons, Jason M. Schmidt

All Peer-Reviewed Publications

Bemisia tabaci (Gennadius) is an economically damaging invasive pest to global vegetable production. Current management strategies rely heavily on insecticides, but increasing levels of resistance raise sustainability concerns. Therefore, strengthening integrated pest management (IPM) programs requires enhancing biocontrol through improved predator-pest interactions. Despite the well-established relevance of functional response modulation by multiple environmental factors, limited research has explored how plant traits and prey life stages interact to influence the efficiency of generalist predators in vegetable systems. To address this gap, we evaluated the functional responses of 2 adult generalist predators, Hippodamia convergens (Guérin-Méneville) and Geocoris punctipes (Say), against 3 nymphal …

Diabetes Mellitus Exacerbates Covid-19 Severity And Prolongs Recovery: A Clinical Study From Southern Iraq, Hussein Ali Hussein Al-Hchaimi, Mohammad Ali Hassan Jassim, Mustafa Abbass, Shahab Abdulla, Ralela Makline

AUIQ Complementary Biological System

Diabetes mellitus (DM) constitutes one of the most consequential comorbidities shaping the clinical trajectory of Coronavirus Disease 2019 (COVID-19), operating through intersecting mechanisms of chronic inflammation, endothelial injury, and immunosuppression that collectively amplify viral pathogenicity. This study investigated the impact of diabetes type on COVID-19 symptom severity, hospitalization duration, and recovery time among patients in Nasiriyah City, southern Iraq — a region substantially underrepresented in the global DM–COVID-19 literature. A descriptive cross-sectional study was conducted across healthcare facilities in Nasiriyah City from 2023 to 2024. A total of 150 hospitalized adult patients carrying confirmed diagnoses of both COVID-19 and type …