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Aids Initiatives In Massachusetts: Building A Continuum Of Care, Nancy Weiland Carpenter

New England Journal of Public Policy

The Health Resource Office was officially established within the Massachusetts Department of Public Health in August 1985 to coordinate policy, education, research, and service response to the AIDS epidemic, and to focus attention on the social and economic impact of the disease. The actual work of the office was begun earlier, in October 1983. This article reviews the activities of the Health Resource Office from October 1983 through June 1987 in allocating resources for AIDS and ARC programs and services. It then describes the conceptual model that evolved during this period for the continuum of services needed to reduce HIV …

The Role Of Education In Aids Prevention, George A. Lamb, Linette G. Liebling

New England Journal of Public Policy

The severity of the current AIDS epidemic, combined with the lack of successful biological interventions, necessitates an active educational program as the primary intervention strategy. Health education theories abound, but relatively little definitive application of these theories has been made to the issues involved with HIV transmission: sexual behavior and the sharing of intravenous drug apparatus. Significant behavior changes have occurred in some people, but the consistency of the behavior change may be difficult to sustain. Thus, the authors suggest that health education should be delivered repeatedly in culturally acceptable language and format, by community leaders, and through many different …

U.S. Women And Hiv Infection, P. Clay Stephens

New England Journal of Public Policy

Women are inadequately provided with HIV services and education and are differentially denied access to these. Divisions of race, ethnicity, economic class, and religion, among others, are compounded by sexual discrimination within each of these categories.

Review of current data on women with AIDS reveals that the reporting methods used convey a false impression that women are not at significant risk. Moreover, the persons indirectly affected by AIDS are predominantly women — mothers, sisters, partners, family members, teachers, and human service workers. Thus, AIDS is more of a women's issue than the statistics imply.

Women, as a gender-defined class, face …

Covering The Plague Years: Four Approaches To The Aids Beat, James Kinsella

New England Journal of Public Policy

AIDS reporting has changed dramatically since 1981. But it was not until mid-1985, when Rock Hudson was diagnosed with the disease, that media outlets began playing the epidemic as a story of major proportions.

Because almost no major media institution embraced the AIDS story as an important issue, coverage of the epidemic was often the result of a reporter's initiative. Consequently, the connection the individual journalist had with the epidemic became a much stronger influence on what appeared in the news and on what Americans knew about the crisis than in any other recent major health story. This article examines …

Editor's Note, Padraig O'Malley

New England Journal of Public Policy

On occasion, the New England Journal of Public Policy will devote an entire issue to consideration of a public policy matter of major importance. The AIDS epidemic is such a matter, with a likely impact of overwhelming consequence well into the twenty-first century. The epidemic raises fundamental questions regarding the nature of individual freedom, our responsibilities to others, the always delicate balance between private rights and the public interest, and society's obligation to its "out" groups — whose members it has stigmatized, discriminated against, ridiculed, and treated as less than full and equal citizens. Indeed, it requires us to ask …

Human Retroviruses: Illustration

New England Journal of Public Policy

An illustration of human retroviruses and the life cycle of retroviruses.

Aids In Children: An Overview Of The Medical, Epidemiological, And Public Health Problems, Ellen R. Cooper

New England Journal of Public Policy

Cases of AIDS in children under thirteen years of age have been described since 1982. Diagnosis is more difficult in children than in adults, owing to the more varied clinical presentation and the difficulty in interpretation of laboratory tests. Current diagnostic criteria of HIV infection are reviewed, as well as symptomatology, natural history, and controversies surrounding management and therapy. Without a full appreciation of the transmissibility of HIV, issues including school and day-care attendance and foster family placement remain emotionally charged. Conflicting public policies contribute to fears on the part of the general public. Because ofthe unique implications for the …

Other Journeys, Phillip Dross

New England Journal of Public Policy

Phillip Dross was a writer. He was forty-three years of age when he died of AIDS in January 1987. Four years earlier, he had come to Newburyport, Massachusetts, to live and to face hard realities about himself — the legacy of a painful, confusing childhood in Florida, where he grew up, bouts with alcoholism, and his own shortcomings as a writer, for although he drove his friends to distraction talking about writing, he could not endure long hours alone, especially at the typewriter.

He made progress — the slow, plodding progress that characterizes the struggle within oneself that can be …

Hiv Antibody Testing: Performance And Counseling Issues, Michael Gross

New England Journal of Public Policy

This article assesses the performance of currently used tests for exposure to human immunodeficiency virus (HIV), the infectious agent associated with acquired immunodeficiency syndrome (AIDS); suggests, in view of that information, guidelines for counseling people seeking HIV antibody testing; and evaluates the claim that because antibody test results will effect behavior change in those who are infected, all members of high-risk groups should be tested.

HIV testing is likely to yield a high proportion of false-positive results in low-risk populations and infants born to infected mothers. A negative result may not establish freedom from infection in high-risk groups or the …

Aids And A-Bomb Disease: Facing A Special Death, Chris Glaser

New England Journal of Public Policy

In 1979 it was called "gay cancer," and it took the life of an acquaintance. Then "gay-related immune deficiency," or GRID, claimed neighbors, friends of friends, fellow activists. I began grief and death counseling with a segment of the population ordinarily concerned with life's ambitions and enjoyments: men in their twenties and thirties. Hospital visits and memorial services became more frequent.

By 1983, when it had come to be called AIDS, my own friends began to be affected. One was a man I dated in seminary, and I was devastated to learn of his illness only upon receiving a notice …

Human Immunodeficiency Virus In Intravenous Drug Users: Epidemiology, Issues, And Controversies, Donald E. Craven

New England Journal of Public Policy

Intravenous drug users are the second most common risk group for acquired immunodeficiency syndrome (AIDS) in the United States, and they account for approximately 25 percent of the cases. Drug users may spread human immunodeficiency virus (HIV) by sharing contaminated drug injection paraphernalia and through sexual contact; women who use drugs can transmit the virus to their children. The rapid spread of HIV in this risk group and the fact that intravenous drug users are a source for heterosexual and perinatal transmission underscore the need for immediate intervention. In addition, many drug addicts are poor, have limited career possibilities, and …

New Hampshire: The Premarital Testing Debacle, Susan D. Epstein

New England Journal of Public Policy

In 1987, the New Hampshire Division of Public Health Services had a bill introduced in the legislature to improve contact tracing and establish statewide public education on HIV infection, transmission, and disease control. This article traces the bill, and issues surrounding the bill, through the legislative process and focuses on an unexpected intervention by the governor through a proposed amendment to add mandatory premarital testing. Its conclusions offer advice to other states on how best to avoid political exploitation of AIDS/HIV issues.

By the summer of 1987, the AIDS issue in New Hampshire had become devoted to everything but AIDS. …

Reliable Detection Of Individuals Seropositive For The Human Immunodeficiency Virus (Hiv) By Competitive Immunoassays Using Escherichia Coli - Expressed Hiv Structural Proteins, G. J. Dawson, J. S. Heller, Charles Wood, R. A. Gutierrez, J. S. Webber, J. C. Hunt, S. A. Hojvat, D. Senn, S. G. Devare, R. H. Decker

Nebraska Center for Virology: Faculty Publications

We molecularly cloned the gag and env genes of the human immunodeficiency virus (HIV) and expressed fragments of these genes in Escherichia coli. Using the recombinant core and envelope proteins, we developed two competitive immunoassays (CIAs). Samples that recognized either the envelope or core proteins were considered positive for antibodies to HIV. This test system was comparable with western blot in detecting antibodies in patients with AIDS or AIDS-related complex that were repeatably reactive in the HIV screening test. All 360 individuals who were positive by western blot were positive by the CIA. A total of 844 samples repeatably …

Genetic Differentiation And Biochemical Polymorphism Among Trichomonads, Steven A. Nadler, B. M. Honigberg

Harold W. Manter Laboratory of Parasitology: Faculty Publications

Isoenzyme electrophoresis was used to study levels of genetic differentiation among strains and clones of Trichomonasg allinae, Trichomonasv aginalis, Tritrichomonafso etus, Tetratrichomonags allinarum, and Pentatrichomonas hominis. Strain variation was found within T. gallinae, T. vaginalis, and T. foetus, however, levels of enzyme polymorphism were greater in T. gallinae than in T. vaginalis or T. foetus. Isoenzyme genotypes were not a stable property of T. gallinae clones cultivated in vitro. Retrospective studies of T. gallinae SG and JB6 clones revealed that mutation occurred during in vitro cultivation. Heterozygotes of hexokinase- 1 and phosphoglucomutase displayed 2 …

Synlophe Of Nematodirus Neotoma (Trichostrongyloidea), Eric P. Hoberg, Lora G. Rickard, Gary L. Zimmerman

Harold W. Manter Laboratory of Parasitology: Faculty Publications

The synlophe of Nematodirus neotoma from Neotoma spp. is characterized. The cervical synlophe is composed of 30-32 and 36-42 ridges in males and females, respectively. Of these, 14 and 20-22 ridges are continuous in the cervical zone and extend to the base of the cephalic expansion. Six pairs of lateral ridges are discontinuous but extend greater than one-third the length of the cervical region. In both males and females, the number of ridges increases posteriad, terminating near the bursa in the male, and extending the entire length of the body in the female. The synonymy of N. neotoma and N. …

Description Of Gracilacus Harnicaudata Sp. N. (Nemata : Criconematidae) With Biological And Histopathological Observations, Ignacio Cid Del Prado Vera, Armand R. Maggenti

Harold W. Manter Laboratory of Parasitology: Faculty Publications

Obese criconematid females and larvae forming colonies were detected under the root cortex attached to the vascular cylinder of redwood roots, Sequoia sempervirens (D. Don) Endl. These specimens have been determined to represent a new species of Criconematidae, Grmilacus lzanzicaudata sp. n. Mature females are obese at midbody but posteriorly the body is constricted and hooked shaped with a rounded tail terminus. Annuli are conspicuous only anteriorly and posteriorly. The cephalic region has four submedian lobes and a circular oral disc. The vulval-lips protrude and the lateral field is marked with four lines. Eggs are partially embedded in a mucoid-like …

Key To Acanthocephala Reported In Waterfowl, Malcolm Edwin Mcdonald,

United States Fish and Wildlife Service: Publications

This is the third part of a continuing series on helminths reported in waterfowl (McDonald 1974, 1981). Coots and moorhens (in Family Rallidae, Order Gruiformes) are included with the Anatidae of Anseriformes. The goal of these studies is complete coverage of waterfowl helminths of the world, although the original incentive-inadequate knowledge of the parasites of North American waterfowl- is less true now. World coverage is desirable because the world distribution of the family, tribes, and even many species of waterfowl often results in world distribution of parasites. The format of this key follows that of the others in the series: …

Clinical Use Of A Standard Kit-Preparation Of Radiolabeled Monoclonal Antibody 96.5 In The Diagnostic Imaging Of Metastatic Melanoma., Mansoor Saleh, D M. Miller, L Peterson, C D. Russell, M W. Unger

Haematology and Oncology, East Africa

We studied the efficiency of a standard-kit preparation using 1 mg 111In-labeled 96.5 monoclonal antibody in combination with 19 mg of unlabeled antibody in the diagnostic imaging of 27 patients with documented metastatic melanoma. Twenty-three of 26 patients (88%) demonstrated immunoscintigraphic localization of tumor. Of 104 metastatic sites previously documented by conventional studies, 62 (60%) were identified by immunoscintigraphy. A total of 77 sites demonstrated localization of radiolabeled antibody. Fifty-four (70%) corresponded to known sites of disease; eight sites (10%) were "discovered" by immunoscintigraphy and subsequently confirmed by conventional studies; 15 imaged sites (20%) could not be confirmed by conventional …

The Effect Of Sodium Chloride On Beta-Hemolytic Streptococci, Bola Fashola

Masters Theses & Specialist Projects

The drug of choice for the treatment of Stieptococcal pharyngitis is penicillin G. However, a common home remedy prescribes the use of salt-water solutions for gargling.

Members of Beta -hemolytic streptococcal groups A, B, and C were isolated from the upper -respiratory tracts of patients diagnosed as having streptococcal pharyngitis. These cultures we:e obtained from HCA Greenview Hospital (Bowling Green, Kentucky) and used to study the effects of sodium chloride on the isolates.

The minimum inhibitory concentration of sodium chloride was determined for each of eight hospital isolates. Croup A streptococci were inhibited at a concentration of 7.2% sodium chloride …

Activation Of The Human Immunodeficiency Virus By Herpes Simplex Virus Type 1, Jeffrey M. Ostrove, John Leonard, Karen E. Weck, Arnold B. Rabson, Howard Gendelman

Nebraska Center for Virology: Faculty Publications

Herpes simplex virus type 1 (HSV-1) and some of its immediate-early genes stimulate expression of the human immunodeficiency virus (HIV) long terminal repeat (LTR) sequences and the replication of HIV itself. To demonstrate this, the HIV LTR was linked to the indicator gene chloramphenicol acetyltransferase (CAT) and transfected into Vero cells with or without the trans-activating gene (tat) of HIV. Infection of these cells with HSV-1 strain KOS or temperature-sensitive mutant tsB2l or tsE6 resulted in a large increase in CAT activity in the absence of tat and further augmentation in the presence of tat. This stimulation was seen at …

Carbon Monoxide-Dependent Chemolithotrophic Growth Of Clostridium Thermoautotrophicum, M. Dean Savage, Zhongren Wu, Steven L. Daniel, Leon L. Lundie Jr, Harold L. Drake

Faculty Research & Creative Activity

The acetogen Clostridium thermoautotrophicum was cultivated under CO-dependent chemolithotrophic conditions. CO-dependent growth profiles and energetics indicated that supplemental CO2 was fundamental to efficient growth at the expense of CO. Overall product stoichiometry approximated 6.5CO --> CH3CO2H + 3.5CO2 + 0.6 cell C + 0.5 unrecovered C. Initial CO/CO2 ratios of 2 to 4 yielded optimal doubling times and cell yields. Maximal YCO values approximated 2.5 g of cell dry weight per mol of CO consumed; Y H2 , was considerably lower than Y CO Cross-transfer growth experiments and protein profiles indicated differential expression of genes between CO and methanol cultures.

Population Dynamics Of The Parasites In Fundulus Zebrinus In The Platte River Of Nebraska, John J. Janovy Jr., Eugene Lee Hardin

John J. Janovy, Jr. Publications

The population dynamics of 7 parasite species or ecotypes were studied in the plains killifish, Fundulus zebrinus, at a single collection site in the South Platte River of Nebraska, U.S.A., for 5 yr. Parasites were: Myxosoma funduli (gill), Trichodina sp. (gill), Gyrodactylus bulbacanthus (gill), Urocleidus fundulus (gill), Gyrodactylus stableri (body surface), and Neascus sp. (= Posthodiplostomum; eyes and body cavity). Parasite densities, prevalences, and variance/mean ratios are reported for 22 samples, totaling 447 fish, over the summer months. Positive correlations were obtained between density and both standardized prevalence and log-transformed variance. Urocleidus fundulus populations were relatively stable with …

Dr. Flexner's Experiment: [Dr. Simon Flexner], M. S. Kaplan

Rockefeller University Research Profiles

Rockefeller University Research Profiles are a series of scientific profiles that were published quarterly, from 1980-1990, by the Rockefeller University. Each issue features the research and achievements of an individual Rockefeller University scientist.

The Feasibility Of Artificial Insemination Of Dairy Cattle Managed By Fulani Tribesmen In Kaduna State, Nigeria, Christian Olafimihan Ojomo

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

This study sought to determine: (a) the essential elements of a viable artificial insemination program for the Fulani Tribesmen in Kaduna State, Nigeria, and (b) to determine if the essential elements of a viable artificial insemination program exist in Kaduna State, Nigeria.

This study was conducted from April 15 to May 15, 1985, in the Artificial Insemination (AI) Subcenters of Zaria, Katsina, Kabomo, Kaduna, Ikara, Zonkwa, Kurmin-Biri, and Kauranjuli.

The data presented in this study were collected by personal interviews with Fulani Tribesmen. The population of this study was from a partial list of Fulani Tribesmen who have had AI …

Vitamin A Status, Anthropometric Measurements, And Food Practices Of Women Of Childbearing Age And Their Preschool Children In Northeast Brazil, Susan Ahlstrom Henderson

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Vitamin A nutrition status was evaluated in 110 pairs of women and their preschool children at rural health posts in two different ecological regions of Northeast Brazil. Serum retinol and carotene, weight, height, tricep skinfold and mid-arm circumference were measured from each mother and child. Nutrition knowledge of mothers, socioeconomic living conditions and consumption of retinol and carotene food sources were assessed.

Nine children (8 percent) and one mother had less than acceptable serum retinol (less than 20 μg/dl). Additionally, 21 percent of the children and six percent of the mothers had "low" serum carotene levels. Thirty-seven percent and 57 …

Health Care Policy Issues Related To Aids: Lessons Learned From The Henry Ford Hospital Experience, David W. Benfer

Henry Ford Hospital Medical Journal

No abstract provided.

Multiple Small Bowel Perforations Secondary To Cytomegalovirus In A Patient With Acquired Immunodeficiency Syndrome, Herman P. Houin, James C. Gruenberg, Evelyn J. Fisher, Eugene Mezger

Henry Ford Hospital Medical Journal

Cytomegalovirus gastroenteritis can be a life-threatening infection in patients with the acquired immunodeficiency syndrome. Although gastrointestinal ulcerations from cytomegalovirus have been widely reported, our patient is only the second case reported with actual perforations in the small bowel.

T-Lymphocyte Subset Studies To Monitor Patients With Aids And Aids-Related Complex, Hajime Hayashi, Eugene Mezger, Michael J. Deegan, Evelyn J. Fisher, Norman Markowitz

Henry Ford Hospital Medical Journal

Multiple specimens from 124 patients from our clinic were evaluated for T4/T8 cell ratio over three to 28 months. Twenty-nine of 30 patients with the acquired immunodeficiency syndrome (AIDS), 58 of 71 patients with AIDS-related complex (ARC), and four of 23 patients at risk showed initial T4/T8 cell ratios of less than 0.8. which either remained unchanged or decreased. Seventeen of 23 AIDS patients and two of 20 ARC patients with a consistently low ratio (0.3 or less) died during the follow-up period. This indicated that the severity of disease could be predicted by periodical T4/T8 cell ratio studies. These …

Gastrointestinal Complications Of Aids: Radiologic Findings, Marc A. Bernstein, Jeremy J. Hollerman, Peter J. Feczko

Henry Ford Hospital Medical Journal

The acquired immunodeficiency syndrome (AIDS) is a significant health problem. Patients with this disease develop unusual infections and neoplasms, many within the gastrointestinal tract. Of the 66 AIDS patients seen over a three-year period at Henry Ford Hospital, 25 patients had AIDS-related gastrointestinal disease, with one death attributed to this cause. The radiologic findings and pathologic correlation of this experience are presented.

The Clinicians' Guide To Creutzfeldt-Jakob Disease, Thomas H. Swanson

Henry Ford Hospital Medical Journal

Creutzfeldt-Jakob disease, a transmissible, rapidly progressive dementia of unknown etiology, mimics Alzheimer's disease, presents in middle life, and affects many central nervous system structures. The disease progresses in three distinct stages, culminating in death. Its occurrence is sporadic and its distribution worldwide. Pathological changes are varied, but spongy degeneration of the neuropil is classic. Research on scrapie, the animal model of Creutzfeldt-Jakob disease, has demonstrated that this unconventional, slow disease is transmitted via a small (less than 50,000 mW) particle, which is composed principally of protein. How this infectious particle, variably named prion, virino, or slow virus, invokes disease or …