Digital Commons Network^™

Effects Of Malting And Fermentation On The Composition And Functionality Of Sorghum Flour, Onesmo N.O. Mella

Department of Food Science and Technology: Dissertations, Theses, and Student Research

Sorghum is an ancient crop grown almost everywhere in the world and used for different purposes. In the U.S, and other developed countries, sorghum is used largely for animal feeding.  In developing countries, especially in Africa and Asia, it is used primarily as human food.

Sorghum is a dependable food crop in Tanzania and its production and use ranks second after maize. Different traditional methods including malting and fermentation have been used in addition to decorticating and milling to process sorghum for the purpose of providing diverse materials. However, sorghum has major drawbacks of poor starch and protein digestibilities that …

The Effect Of Energy Patches On Substrate Utilization In Collegiate Cross-Country Runners, Ryan E. Fiddler, Doug Smith, Bert Jacobson, Crishel Klein, Aric Warren, Matt O'Brien, Brennan Thompson, Lee Everett

International Journal of Exercise Science

It is well established that an increased capacity of skeletal muscle to oxidize fatty acids can spare glycogen and delay the onset of fatigue in mild- to moderate-intensity exercise. The purpose of the following study was to examine the effect of LifeWave® energy patches on non-protein substrate utilization in Division-1 cross-country runners. To determine the effect of the patches subjects were pretested to establish baselines and randomly assigned to an experimental (EX) or placebo (PL) group. Twenty-two trained male (n = 11; mean ± SD, age = 21.1 ± 2.6years, height = 179.6 ± 4.2cm, body mass = 71.4 ± …

Estrogenic Regulation Of The Immune System In A Murine Model For Systemic Lupus Erythematosus, Matthew James Zuber

Biology Honors Papers

Systemic Lupus Erythematosus is a damaging autoimmune disease afflicting millions of people worldwide. Lupus is characterized by an overabundance of autoantibodies, proteins directing the immune system to destroy a person's own body, what it would normally be protecting. The molecular mechanisms, environmental influences, and genetic predispositions of Lupus are not yet fully understood. However, nine out of ten Lupus patients are women between the age of puberty and menopause, when estrogen levels are highest. The fact that women are significantly more prone to suffer from Lupus than men leads experts to believe that the sex hormone estrogen which is present …

A User's Guide To The Encyclopedia Of Dna Elements (Encode), Morgan Giddings, Brian Risk

Biology Faculty Publications and Presentations

The mission of the Encyclopedia of DNA Elements (ENCODE) Project is to enable the scientific and medical communities to interpret the human genome sequence and apply it to understand human biology and improve health. The ENCODE Consortium is integrating multiple technologies and approaches in a collective effort to discover and define the functional elements encoded in the human genome, including genes, transcripts, and transcriptional regulatory regions, together with their attendant chromatin states and DNA methylation patterns. In the process, standards to ensure high-quality data have been implemented, and novel algorithms have been developed to facilitate analysis. Data and derived results …

Noise And Complexity In Human Postural Control: Interpreting The Different Estimations Of Entropy, Christopher K. Rhea, Tobin A. Silver, S. Lee Hong, Joong Hyun Ryu, Breanna E. Studenka, Charmayne M. L. Hughes, Jeffrey M. Haddad

Kinesiology and Health Science Faculty Publications

Background: Over the last two decades, various measures of entropy have been used to examine the complexity of human postural control. In general, entropy measures provide information regarding the health, stability and adaptability of the postural system that is not captured when using more traditional analytical techniques. The purpose of this study was to examine how noise, sampling frequency and time series length influence various measures of entropy when applied to human center of pressure (CoP) data, as well as in synthetic signals with known properties. Such a comparison is necessary to interpret data between and within studies that use …

Physiology Of Yawning : Proximate Mechanisms Supporting An Ultimate Function, Melanie Lee Shoup-Knox

Legacy Theses & Dissertations (2009 - 2024)

Recent research suggests that yawning functions to cool the brain during periods of mild hyperthermia. Evidence for this hypothesis is largely behavioral, and includes reports of increased yawning during increases in ambient temperature and times of stress as well as an amelioration of yawning upon nasal breathing and forehead cooling. Little research has been published on the physiological mechanisms supporting a brain cooling function, however. The current set of studies explores human and animal physiological parameters in search of evidence of brain cooling during yawning. In humans, heart rate, skin temperature, and skin conductance findings suggest that yawning involves an …

The Role Of Zip Superfamily Of Metal Transporters In Chronic Diseases, Purification & Characterization Of A Bacterial Zip Transporter: Zupt., Iryna King

Wayne State University Theses

In mammals zinc is the second most abundant essential trace metal. Since Zn² is a small, hydrophilic, and a highly charged ion, it cannot be transported across the plasma or intracellular organelle membrane by passive diffusion. Different types of cells require a different constant concentration of zinc at all times. Presence of excess free Zn ions can be toxic to the cell. All cells must have tightly regulated homeostatic mechanisms in order to preserve healthy levels and proper compartmentalization of zinc. This is accomplished through the actions of specialized proteins that facilitate zinc uptake, efflux and compartmentalization. If the …

Lysophosphatidic Acid Production And Signaling In Platelets, Zachary Bennett Fulkerson

Theses and Dissertations--Physiology

Lysophosphatidic acid (LPA) belongs to a class of extracellular lipid signaling molecules. In the vasculature, LPA may regulate platelet activation and modulate endothelial and smooth muscle cell function. LPA has therefore been proposed as a mediator of cardiovascular disease.

The bulk of circulating LPA is produced from plasma lysophosphatidylcholine (LPC) by autotaxin (ATX), a secreted lysophospholipase D (lysoPLD). Early studies suggest that some of the production of circulating LPA is platelet-dependent. ATX possesses an N-terminal somatomedin B-like domain suggesting the hypothesis that ATX interacts with platelet integrins which may localize ATX to substrate in the membrane and/or alter the catalytic …

Omega-3 Fatty Acids And The Neurovascular Responses To Mental Stress In Humans, Christopher Elmer Schwartz

Dissertations, Master's Theses and Master's Reports - Open

Hypertension is the most prevalent form of cardiovascular disease (CVD) in the world, and is known to increase the risk for developing other diseases. Recently, the American Heart Association introduced a new classification of blood pressure, prehypertension (PHT). The criteria for PHT include a systolic of 120-139 mmHg and/or a diastolic blood pressure of 80-89 mmHg. It has been observed that individuals with PHT have a higher risk of developing hypertension later in life. Therefore, it is important to understand the mechanisms contributing to PHT in order to possibly prevent hypertension. Omega-3 fatty acids found in fish oils have been …

Dietary Selenium Affects Host Selenoproteome Expression By Influencing The Gut Microbiota, Marina V. Kasaikina, Marina A. Kravtsova, Byung Cheon Lee, Javier Seravalli, Daniel A. Peterson, Jens Walter, Ryan Legge, Andrew K. Benson, Dolph L. Hatfield, Vadim Gladyshev

Department of Food Science and Technology: Faculty Publications

Colonization of the gastrointestinal tract and composition of the microbiota may be influenced by components of the diet, including trace elements. To understand how selenium regulates the intestinal microflora, we used high-throughput sequencing to examine the composition of gut microbiota of mice maintained on selenium-deficient, selenium-sufficient, and selenium-enriched diets. The microbiota diversity increased as a result of selenium in the diet. Specific phylotypes showed differential effects of selenium, even within a genus, implying that selenium had unique effects across microbial taxa. Conventionalized germfree mice subjected to selenium diets gave similar results and showed an increased diversity of the bacterial population …

Elucidating Functional Roles For Myogenin In Adult Skeletal Muscle Metabolism, Exercise Capacity, And Regeneration, Jesse Flynn

Dissertations and Theses (Open Access)

The four basic helix-loop-helix myogenic transcription factors, myogenin, Myf5, MRF4, and MyoD are critical for embryonic skeletal muscle development. Myogenin is necessary for the terminal differentiation of myoblasts into myofibers during embryogenesis, but little is known about the roles played by myogenin in adult skeletal muscle function and metabolism. Furthermore, while metabolism is a well-studied physiological process, how it is regulated at the transcriptional level remains poorly understood. In this study, my aim was to determine the function of myogenin in adult skeletal muscle metabolism, exercise capacity, and regeneration. To investigate this, I utilized a mouse strain harboring the Myogflox …

Bio-Inspired Innovation And National Security, Robert E. Armstrong, Mark D. Drapeau, Cheryl A. Loeb, James J. Valdes

Books

Despite various treaties and protocols, offensive biological weapons use has continued to this day, with the anthrax attacks of 2001 being the most recent incident. Such activity has led to a strong defensive program, with medical science developing numerous countermeasures that have benefited both civilian and military populations.

Role Of Ampk In The Upregulation Of Steroidogenic Acute Regulatory Protein In The Zona Fasciculata Of The Adrenal Cortex, Adam Wesley Dayton

Theses and Dissertations

Cortisol is a glucocorticoid produced by the zona fasciculata (ZF) of the adrenal cortex. Traditionally, cortisol production and release was seen as being regulated strictly by adrenocorticotropic hormone (ACTH). While this is true of baseline cortisol levels and in response to acute mental stress, the picture is somewhat more complicated in other situations.Interleukin-6 (IL-6) contributes to the maintenance of cortisol levels in situations of prolonged immune or inflammatory stress. AMP activated protein kinase (AMPK) was investigated as a possible mediator of the action of IL-6 or as an independent actor in raising cortisol levels in response to hypoxemic or hypoglycemic …

Strategies To Employ Androstenediol To Reverse Steroid Inhibited Healing In A Rat Model Of Trauma, Francis Diskin

Theses and Dissertations

Much of our current understanding regarding trauma, mechanisms of healing, and treatment strategies have evolved as a result of injuries suffered during armed conflict. While our understanding of these processes has advanced during and since these conflicts, treatment methods of traumatic wound healing have failed to progress significantly in the last forty years. The overall objective of this research was to test the hypothesis that the immune regulating hormone Androstenediol (AED) modulates the host’s immune system to promote wound healing under conditions where it has been inhibited by stress and infection. In an effort to characterize the effects of Androstenediol …

Development And Use Of A Physiologically Based Mathematical Model Describing The Relationships And Contributions Of Macronutrients To Weight And Body Composition Changes, Saori Sakita

Theses and Dissertations

The effect of the dietary macronutrient composition on weight loss has been a controversial issue for decades. During that time, a high-protein, high-fat, and low-carbohydrate diet has been one of the more popular weight loss diets with the public. We hypothesized that a computer simulation model using STELLA software could help to better understanding the effect of the dietary macronutrient composition on weight loss. We calculated daily total oxidation instead of total energy expenditure as others have done based on the facts that carbohydrate, fat, and protein intake influence carbohydrate, fat, and protein oxidation. In order to create a simple …

Grand Challenges In Comparative Physiology: Integration Across Disciplines And Across Levels Of Biological Organization, Donald L. Mykles, Cameron K. Galambor, Jonathon H. Stillman, Lars Tomanek

Biological Sciences

No abstract provided.

The Effect Of Virtual Reality On Gait Variability, Dimitrios Kastavelis, Mukul Mukherjee, Leslie M. Decker, Nikolaos Stergiou

Journal Articles

Optic Flow (OF) plays an important role in human locomotion and manipulation of OF characteristics can cause changes in locomotion patterns. The purpose of the study was to investigate the effect of the velocity of optic flow on the amount and structure of gait variability. Each subject underwent four conditions of treadmill walking at their self-selected pace. In three conditions the subjects walked in an endless virtual corridor, while a fourth control condition was also included. The three virtual conditions differed in the speed of the optic flow displayed as follows – same speed (OFn), faster (OFf), and slower (OFs) …

The Use Of Horticulture And Gardening As A Special Education Tool At The High School Level, Krysta Marie Johnson

Horticulture and Crop Science

THIS REPORT CONTAINS PLANNING METHODS AND INSTALLATION PROCEDURE FOR A RAISED VEGETABLE GARDEN FOR WILSONVILLE HIGH SCHOOL, IN WILSONVILLE, OREGON. THE PRIMARY PURPOSE OF THE GARDEN WAS TO USE IT AS A LEARNING TOOL FOR THE SPECIAL EDUCATION DEPARTMENT AT WILSONVILLE HIGH SCHOOL. UPON DOING MORE RESEARCH IT BECAME EVIDENT THAT THE GARDEN CAN ALSO BE USED AS A HEALING TOOL FOR STUDENTS WHO SUFFER FROM ATTENTION DISORDERS AND WHO HAVE EMOTIONAL AND LEARNING DISABILITIES. THE STUDENTS HAVE BECOME INVESTED IN THE GARDEN PROJECT AND LOOK FORWARD TO DOING MORE PROJECTS WITH THEIR CLASS.

Activation Of Gabaa And 5ht1a Receptors In The Raphe Pallidus Abolish The Cardiovascular Responses To Stress In Conscious Rats, Nhut Minh Pham Le

Masters Theses, 2010-2019

Serotonergic neurons of the raphe pallidus area of the brainstem are involved in the cardiovascular responses to stress. However, the manner in which they mediate these responses is not well understood and severe abnormalities in this system have been associated with Sudden Infant Death Syndrome. In the current study, microinjections of muscimol and 8-OH-DPAT (GABAA and 5HT1A receptor agonists, respectively) into the raphe pallidus abolished the increase in mean arterial pressure and the tachycardiac responses following air jet, handing, and restraint stress that were observed following microinjections of artificial cerebrospinal fluid. The stress responses following muscimol microinjections suggest that this …

Lineage-Specific Patterns Of Functional Diversification In The Α- And Β-Globin Gene Families Of Tetrapod Vertebrates, Federico G. Hoffmann, Jay F. Storz, Thomas A. Gorr, Juan C. Opazo

Jay F. Storz Publications

The α- and β-globin gene families of jawed vertebrates have diversified with respect to both gene function and the developmental timing of gene expression. Phylogenetic reconstructions of globin gene family evolution have provided suggestive evidence that the developmental regulation of hemoglobin synthesis has evolved independently in multiple vertebrate lineages. For example, the embryonic β-like globin genes of birds and placental mammals are not 1:1 orthologs. Despite the similarity in developmental expression profiles, the genes are independently derived from lineage-specific duplications of a β-globin pro-ortholog. This suggests the possibility that other vertebrate taxa may also possess distinct repertoires of globin genes …

Human Physiology Community Education, Sasha Volgamore, Kristen Mitchell

Service-Learning Program

The purpose of our project was to educate community members of all age groups to provide them with a basic knowledge of the fundamental workings of the human body, with specific emphasis on skeletal muscle physiology and cardiovascular physiology. It is our hope that members of our target audiences will use this information for future self-directed inquiries into human physiology with regard to their own bodies. Regardless of their age, everyone can decide to eat healthier and live a more active lifestyle. With the knowledge we provided the community, we hope they will appreciate that a healthy lifestyle is paramount …

Evidence-Based Practice In Undergraduate Athletic Training Education, Sarah A. Manspeaker

Human Movement Studies & Special Education Theses & Dissertations

As Evidence-Based Practice (EBP) has progressed within medicine, nursing, and physical therapy, athletic training has been subsequently slow to infuse EBP and its associated concepts at the professional level. The aim of Project I was to determine athletic training instructors experience and use of evidence-based concepts (EBC) during instruction through emergent design qualitative interviews. Project II was designed to establish the Evidence-Based Teaching Model (EBTM) as a tool for athletic training educators' to use to introduce EBP concepts to professional students.

Project I featured 11 educators from Commission on Accreditation of Athletic Training Education (CAATE) programs. Instructors identified primary approaches …

Urban And Community Forests Of The North Central West Region, David J. Nowak, Eric J. Greenfield

United States Department of Agriculture, Forest Service / University of Nebraska-Lincoln: Faculty Publications

This report details how land cover and urbanization vary within the states of Iowa, Kansas, Minnesota, Missouri, Nebraska, North Dakota, and South Dakota by community (incorporated and census designated places), county subdivision, and county. Specifically this report provides critical urban and community forestry information for each state including human population characteristics and trends, changes in urban and community lands, tree canopy and impervious surface cover characteristics, distribution of land-cover classes, a relative comparison of urban and community forests among local government types, determination of priority areas for tree planting, and a summary of urban tree benefits. Report information can improve …

How Our Health Depends On Biodiversity, Eric Chivian M.D., Aaron Bernstein M.D., M.P.H.

Ecosystem Disruption & Climate Change

The eminent Harvard biology Professor Edward O.Wilson once said about ants, “We need them to survive, but they don’t need us at all.” The same, in fact, could be said about countless other insects, bacteria, fungi, plankton, plants, and other organisms. This fundamental truth, however, is largely lost to many of us. Rather, we humans often act as if we are totally independent of Nature, as if our driving thousands of other species to extinction and disrupting the life-giving services they provide will have no effect on us whatsoever.

This summary, using concrete examples from our award-winning Oxford University Press …

Complexity And Human Gait, Leslie M. Decker, Fabien Cignetti, Nikolaos Stergiou

Journal Articles

Recently, the complexity of the human gait has become a topic of major interest within the field of human movement sciences. Indeed, while the complex fluctuations of the gait patterns were, for a long time, considered as resulting from random processes, the development of new techniques of analysis, so-called nonlinear techniques, has open new vistas for the understanding of such fluctuations. In particular, by connecting the notion of complexity to the one of chaos, new insights about gait adaptability, unhealthy states in gait and neural control of locomotion were provided. Through methods of evaluation of the complexity, experimental results obtained …

Nebraska Biomechanics Core Facilty 2009 Annual Report, Issue 8, Nebraska Biomechanics Core Facility

Biomechanics Annual Report

April 2009 - March 2010

This issue features Announcements, Featured News, Projects, Collaborations, Visitors, Awards, Publications, and Support.

Characterization Of Tram, A Required Bacteroides Fragilis Conjugal Apparatus Protein That Interacts With The B. Fragilis Putative Coupling Protein Bcta And The B. Fragilis Relaxase Protein Bmph, Mai Thi Thanh Nguyen

Dissertations

Bacteroides spp. organisms, the most prominent bacteria of the human colon, are reservoirs of antibiotic resistance genes which promiscuously transfer within and from the genus via conjugation. The B. fragilis clinical isolate LV23 harbors a 37kb conjugative transposon, BTF-37. Two important conjugal apparatus proteins encoded by BTF-37 are BctA, a predicted coupling protein (CP) that powers DNA translocation, and ORF7 (TraM). In this study, we demonstrated that TraM exhibits characteristics of a required conjugal apparatus protein including 1) upregulated expression under conjugation conditions; 2) localization to the bacterial inner membrane; 3) interaction with the putative coupling protein BctA and the …

Infants Born Preterm Exhibit Different Patterns Of Center-Of-Pressure Movement Than Infants Born At Full Term, Stacey C. Dusing, Anastasia Kyvelidou, Vicki S. Mercer, Nikolaos Stergiou

Journal Articles

Background: Infants born preterm are at risk for developmental impairments related to postural control.

Objective: The purpose of this study was to determine whether infants born preterm and infants born at full term differed in postural control at 1 to 3 weeks after term age.

Design: This study included 17 infants born preterm (mean gestational age=31.9 weeks, range=25.0–34.6) and 15 infants born at full term (mean gestational age=38.9 weeks, range=37.3–40.6). All infants were without diagnosed neurological or genetic conditions.

Measurement: Center-of-pressure (COP) data were recorded at 5 Hz while each infant was positioned supine on a pressure-sensitive mat …

Head And Neck Embryology: An Overview Of Development, Growth And Defect In The Human Fetus, Allison Baylis

Honors Scholar Theses

The purpose of this research is to explore the growth and formation of the head and neck from embryological development through puberty in order to understand how this knowledge is necessary for the development of dental and medical treatments and procedures. This is a necessary aspect of the medical and dental school curriculum at the University of Connecticut Health Center Schools of Medicine and Dental Medicine that needs to be incorporated into the current study of embryology for first-year students. Working with Dr. Christine Niekrash, D.M.D, this paper will cover the embryology and growth of the head, face and oral …

Knockdown Of Kiaa0319 Reduces Dendritic Spine Density, Daniel Young Kim

Honors Scholar Theses

Developmental Dyslexia is a reading disorder that affects individuals that possess otherwise normal intelligence. Until the four candidate dyslexia susceptibility genes were discovered, the cause of cortical malformations found in post mortem dyslexic brains was unclear. Normal brain development is crucial for the proper wiring of the neural circuitry that allow an individual to perform cognitive tasks like reading. For years, familial and twin studies have suggested that there was a genetic basis to the causation of dyslexia. Kiaa0319 was among the candidate dyslexia susceptibility genes that were ascertained. KIAA0319 is located on Chromosome 6p22.2-22.3 and has been found to …