Digital Commons Network^™

How To Write A Doctoral Thesis, H R. Ahmad

Department of Biological & Biomedical Sciences

No abstract provided.

The Healthfulness Of Entrées And Students’ Purchases In The Campus Dining Environment, Krista Leischner

Electronic Theses and Dissertations

The purpose of this study is to determine the availability of “more” versus “less healthful” entrée items in the campus dining environment and also to determine if students’ purchases are reflective of what is offered.
Entrée items were categorized as either “more” or “less healthful” according to the American Heart Association guidelines. Students’ entrée purchases from the 2014- 2015 school year were analyzed at a Midwestern university. The relationship between students’ demographics and food purchases was also analyzed in this observational study. Significant differences between more healthful and less healthful purchased and available items were determined using a Chi-square test. …

Microbes And Alzheimer's Disease, Ruth Itzhaki, Richard Lathe, Brian J. Balin, Melvyn J. Ball, Elaine L. Bearer, Heiko Braak, Maria J. Bullido, Chris Carter, Mario Clerici, Et Al.

PCOM Scholarly Works

We are researchers and clinicians working on Alzheimer's disease (AD) or related topics, and we write to express our concern that one particular aspect of the disease has been neglected, even though treatment based on it might slow or arrest AD progression. We refer to the many studies, mainly on humans, implicating specific microbes in the elderly brain, notably herpes simplex virus type 1 (HSV1), Chlamydia pneumoniae, and several types of spirochaete, in the etiology of AD. Fungal infection of AD brain has also been described, as well as abnormal microbiota in AD patient blood. The first observations of HSV1 …

Role Of Adrenergic Neurons In Motor Control: Examination Of Cerebellar Purkinje Neurons In Mice Following Selective Adrenergic Cell Ablation In Vivo, Monica Mansour

Honors Undergraduate Theses

Phenylethanolamine-N-methyltransferase (Pnmt) is the enzyme that catalyzes the conversion of noradrenaline to adrenaline. These catecholamines are synthesized in the medulla of the adrenal gland and by some neurons of the central nervous system. The precise location of Pnmt action in the brain and its physiological significance are unknown. Prior studies led by Aaron Owji, a graduate student in Dr. Ebert’s laboratory, showed that mice with selectively ablated Pnmt cells show signs of neurological defects such as abnormal gait, weakened grip strength, lack of balance, reduced movement, and defective reflexes during tail suspension tests.

The cerebellum is a small section of …

Open Educational Resources Textbook List, Zachariah Claybaugh, Chelsea Stone

Librarian Publications

Discipline specific OER textbook list for departments at SHU, compiled by Zach Claybaugh and Chelsea Stone.

You Can't Catch A Fish With A Robot, R. Grant Gilmore Jr.

Gulf and Caribbean Research

Abstract

In this essay I will relate the challenges associated with deep sea ocean exploration as well as the advantages and disadvantages of today’s ocean technologies based on experience with most of these systems. After nearly five decades using robotic vehicles (Remotely Operated Vehicles = ROVs and Autonomous Underwater Vehicles = AUVs) and manned submarines for fish research, I thought it would be appropriate to briefly describe a career spent using these technologies as they were developed. Deep sea ichthyologists cannot effectively catch a swimming fish with a robot even 40 years after the development of the first ROV for …

From Sentience To Science: Limits Of Anthropocentric Cognition, Charukeshi Chandrasekera

Animal Sentience

Donald Broom’s Sentience and Animal Welfare (2014) is an intellectually and morally engaging book written with radical new concepts in mind. It deals with many issues that are central to the animal welfare debate such as brain complexity, cognitive ability, when in life sentience begins, and how it all affects the way we endorse welfare. It addresses how our insatiable quest to define the uniqueness of our own species has led us to ignore logic and scientific evidence. It also brings greater clarity to these precarious positions and outlines pragmatic approaches to tackling this complex topic of sentience and welfare.

Front Matter

The Synapse: Intercollegiate science magazine

No abstract provided.

A Mycobacterium Avium Subsp. Paratuberculosis Predicted Serine Protease Is Associated With Acid Stress And Intraphagosomal Survival, Abirami Kugadas, Elise A. Lamont, John Bannantine, Fernanda Miyagaki Shoyama, Evan Brenner, Harish K. Janagama, Srinand Sreevatsan

United States Department of Agriculture-Agricultural Research Service / University of Nebraska-Lincoln: Faculty Publications

The ability to maintain intra-cellular pH is crucial for bacteria and other microbes to survive in diverse environments, particularly those that undergo fluctuations in pH. Mechanisms of acid resistance remain poorly understood in mycobacteria. Although, studies investigating acid stress in M. tuberculosis are gaining traction, few center on Mycobacterium avium subsp. paratuberculosis (MAP), the etiological agent of chronic enteritis in ruminants. We identified a MAP acid stress response network involved in macrophage infection. The central node of this network was MAP0403, a predicted serine protease that shared an 86% amino acid identity with MarP in M. tuberculosis. Previous studies confirmed …

Student Buy-In To Active Learning In A College Science Course, Andrew J. Cavanagh, Oriana R. Aragon, Xinnian Chen, Brian A. Couch, Mary F. Durham, Aiyana Bobrownicki, David I. Hanauer, Mark J. Graham

School of Biological Sciences: Faculty Publications

The benefits of introducing active learning in college science courses are well established, yet more needs to be understood about student buy-in to active learning and how that process of buy-in might relate to student outcomes. We test the exposure–persuasion– identification–commitment (EPIC) process model of buy-in, here applied to student (n = 245) engagement in an undergraduate science course featuring active learning. Student buy-in to active learning was positively associated with engagement in self-regulated learning and students’ course performance. The positive associations among buy-in, self-regulated learning, and course performance suggest buy-in as a potentially important factor leading to student …

The Study Of The Regulon Of Oxyr In Escherichia Coli And Porphyromonas Gingivalis, Christopher K. Pham

Theses and Dissertations

The facultative anaerobe, Escherichia coli and the obligate anaerobe, Porphyromonas gingivalis are two bacteria that reside in our body. Although they reside in separate environments, they are both subject to hydrogen peroxide stress and have mechanisms to regulate the stress. OxyR is the primary transcriptional regulator/sensor of oxidative stress response caused by hydrogen peroxide. OxyR in P. gingivalis is not well-characterized compared to OxyR in E. coli. We sought to characterize and compare the two forms of OxyR in order to gain a better understanding of the protein. We determined the oligomeric state of both proteins: primarily a tetramer for …

Review Of "Race Unmasked: Biology And Race In The Twentieth Century" By M. Yudell, John B. Jenkins

Biology Faculty Works

No abstract provided.

Development And Testing Of Supplemental Materials For An Undergraduate Healthy Food Product Development Curriculum, Breanne Halteman

All Theses

ABSTRACT The goal of this research project was three-fold: (1) to follow up with students who had taken the Applied Interdisciplinary Product Development (AIPD) course two years prior to assess the long-term effect of the course on perceived self-confidence in product development skills, connectedness with the department, and preparedness to enter the industry; (2) to design, implement, and evaluate course materials educating undergraduate students about the subjects of herbs, spices, and sensory science; and (3) to evaluate the success of dissemination of a sophomore-level hybrid course on healthy food product development. A Subject Knowledge Assessment (SKA) was designed to measure …

Influence Of Lactobacillus Rhamnosus Isolated From “Amabere Amaruranu” Cultured Milk On Adipogenesis, Justin E. Kotala

Electronic Theses and Dissertations

This study was performed to test the in vitro effects of a Lactobacillus rhamnosus isolate from “amabere amaruranu”, a traditional Kenyan cultured milk, on 3T3-L1 and Caco-2 cell lines. Cultures of fully mature 3T3-L1 adipocytes were treated with bacterial isolate cell extract (CE), filtered spent broth (FSB) from overnight bacterial culture, or with a PBS control. Expression levels of PPAR³1 and 2, C/EBP±, and ATGL proteins in 3T3-L1 cells were upregulated by FSB treatment. CE treatment did not affect protein expression levels. Expression of MTTP and SREBP-1c proteins in Caco-2 cells showed no change with either treatment. Optical density measurements …

Efficacy Of Galactooliosaccharide (Gos) And/Or Rhamnose-Based Synbiotics In Enhancing Ecological Performance Of Lactobacillus Reuteri In The Human Gut And Characterization Of Its Gos Metabolic System, Monchaya Rattanaprasert

Department of Food Science and Technology: Dissertations, Theses, and Student Research

Probiotic L. reuteri has potential to produce antimicrobial compounds and secrete immunosuppressive factors. These metabolic attributes could benefit the human host by providing colonization resistance (competitive and metabolic exclusion) against enteropathogens and mitigating inflammation. As metabolically active cells are fundamental to such probiotic properties, synbiotic approaches that supply L. reuteri with a source(s) of carbon, energy, and/or external electron acceptor for cell growth in the gut environment could therefore prompt the probiotic to engage in beneficial activities. In this study, the efficacy of GOS and/or rhamnose-based synbiotic approaches in promoting colonization persistence and metabolic activity of L. reuteri was evaluated. …

The Flaws And Human Harms Of Animal Experimentation, Aysha Akhtar

Experimentation Collection

Nonhuman animal (“animal”) experimentation is typically defended by arguments that it is reliable, that animals provide sufficiently good models of human biology and diseases to yield relevant information, and that, consequently, its use provides major human health benefits. I demonstrate that a growing body of scientific literature critically assessing the validity of animal experimentation generally (and animal modeling specifically) raises important concerns about its reliability and predictive value for human outcomes and for understanding human physiology. The unreliability of animal experimentation across a wide range of areas undermines scientific arguments in favor of the practice. Additionally, I show how animal …

The Flaws And Human Harms Of Animal Experimentation, Aysha Akhtar

Morality and Ethics of Animal Experimentation Collection

Nonhuman animal (“animal”) experimentation is typically defended by arguments that it is reliable, that animals provide sufficiently good models of human biology and diseases to yield relevant information, and that, consequently, its use provides major human health benefits. I demonstrate that a growing body of scientific literature critically assessing the validity of animal experimentation generally (and animal modeling specifically) raises important concerns about its reliability and predictive value for human outcomes and for understanding human physiology. The unreliability of animal experimentation across a wide range of areas undermines scientific arguments in favor of the practice. Additionally, I show how animal …

University Of Nebraska At Omaha Biomechanics Annual Report, Fall 2015, Biomechanics Research Building

Biomechanics Annual Report

This annual report includes:

Letter from the Director; B.S. in Biomechanics; QLI Partnership

Center for Research in Human Movement Variability: Formation of the Center; Breathing and Walking Coupling Variability in COPD; Gait Variability in Patients with Peripheral Arterial Disease; Development of Postural Control Variability in Autism; The Effects of Virtual Reality on Gait Variability After Stroke; Pilot Grants; COBRE Research Day; New Hires in the Center

Updates: Why Choose the BRB? Where Are They Now? From the Bench to the Market: New Partnership Paves the way to Pre-Symptomatic Disease Detection; Fun Facts; New Quipment

Other Projects: Space Navigation; Neuroscience; Prosthetics; …

Characterization Of Inhibitors Of Fatty Acid Transport Protein-2 In Cell And Animal Models, Nipun Saini

Department of Biochemistry: Dissertations, Theses, and Student Research

Obesity is correlated with insulin resistance and elevated levels of glucose, triglycerides and free fatty acids in blood. This affects overall metabolism and leads to disease. In the obese state, fat also accumulates in non-adipose tissue including liver, muscle and pancreas, where it can lead to cellular dysfunction and death. Currently, only a limited number of drugs are available to combat obesity and it is clear that new drugs, which more narrowly target the metabolic pathways involved, are required. Fatty Acid Transport Proteins (FATPs) are bifunctional proteins involved in the uptake and activation of fatty acids by esterification with coenzyme …

Oleogustus: The Unique Taste Of Fat, Cordelia A. Running, Bruce A. Craig, Richard D. Mattes

Department of Nutrition Science Faculty Publications

Considerable mechanistic data indicate there may be a sixth basic taste: fat. However, evidence demonstrating that the sensation of non-esterified fatty acids (the proposed stimuli for “fat taste”) differs qualitatively from other tastes is lacking. Using perceptual mapping, we demonstrate that medium and long-chain non-esterified fatty acids have a taste sensation that is distinct from other basic tastes (sweet, sour, salty, and bitter). While some overlap was observed between these NEFA and umami taste, this overlap is likely due to unfamiliarity with umami sensations rather than true similarity. Shorter chain fatty acids stimulate a sensation similar to sour, but as …

Biomechanical Comparisons Of The Power Clean And Power Hang Clean Exercises At Different Relative Intensities, Jacob Troy Caldwell

Master's Theses and Doctoral Dissertations

The purpose of this study was to compare normalized peak power (PP) and peak barbell acceleration (BA) between the power clean (PC) and power hang clean (PHC) exercises among eight male weightlifters (25.5 ℗ł 2.86 yr; 85.25 ℗ł 11 kg). Biomechanical comparisons were made between both exercises at 60%, 70%, and 80% of each subject⁰́₉s one repetition maximum (1RM). When comparing both exercises for normalized PP, there was no significant difference at 60% and 70% of 1RM. At 80% 1RM, the PHC demonstrated significance (p = 0.016) with higher normalized PP when compared to the PC. When comparing both exercises …

Influence Of Native And Processed Cereal Grain Fibers On Gut Health, Junyi Yang

Department of Food Science and Technology: Dissertations, Theses, and Student Research

Cereal fibers that can be metabolized by gut microbiota have been shown to promote the growth of beneficial bacteria in the gut. Increased consumption of cereal fibers may improve host / gut microbiota interactions in obesity and other metabolic diseases by normalizing gut dysbiosis. The present dissertation describes four research projects to assess the impact of cereal dietary fibers on gut microbiota and host metabolism. In the first study, we determined the treatment temperatures for production of soluble, non-digestible, feruloylated oligo- and polysaccharides (FOPS) from maize bran and wheat bran, and determined the fermentation properties of partially purified FOPS from …

Effect Of Beetroot Juice On Self-Regulated, Moderate-Intensity Exercise, Jordyn N. Rienks, Andrea A. Vanderwoude, Elizabeth Maas, Zachary M. Blea, Andrew W. Subudhi

International Journal of Exercise Science

International Journal of Exercise Science 8(3): 277-286, 2015. Dietary nitrate supplementation has been shown to reduce oxygen consumption at a fixed work rate. We questioned whether a similar effect would be observed during variable work rate exercise at a specific rating of perceived exertion (RPE), as is commonly prescribed for aerobic training sessions. Using a double-blind, placebo controlled, crossover design, ten females (25 ± 3 years; VO₂peak 37.1 ± 5.3 ml/kg/min) performed two 20-min cycle ergometer trials at a constant RPE of 13 (somewhat hard) 2.5 hours following ingestion of 140 ml of concentrated beetroot juice (12.9 mmol …

Functional Characterization Of A Cathepsin L In Drosophila Melanogaster, Qian Dong

Masters Theses & Specialist Projects

The Drosophila dorsal Air Sac Primordium (ASP) is a tracheal tube that invasively grows toward and into the wing imaginal disc. The unfolding of Drosophila wing is a process following eclosion with a cuticular bilayer replacing epithelial cells originally packing the wing. We reasoned that protease functions might be needed for the invasion of ASP into the wing imaginal disc as well as the rearrangement of epithelia cells during wing unfolding. Our study is particularly focused on understanding the role of a Cathepsin L like cysteine protease (CP1) in the development of dorsal ASP and wing development of Drosophila melanogaster. …

Suspension Model For Blood Flow Through A Tapering Catheterized Inclined Artery With Asymmetric Stenosis, Devajyoti Biswas, Moumita Paul

Applications and Applied Mathematics: An International Journal (AAM)

We intend to study a particle fluid suspension model for blood flow through an axially asymmetric but radially symmetric mild stenosis in the annular region of an inclined tapered artery and a co-axial catheter in a suitable flow geometry has been considered to investigate the influence of velocity slip at the stenotic wall as well as hematocrit, shape parameter. The model also includes the tapering effect and inclination of the artery. Expressions for the flow variables have been derived analytically and their variations with various flow parameters are represented graphically. The results for the different values of the parameters involved …

Effects Of Ibuprofen And Caffeine Concentrations On The Common Bed Bug (Cimex Lectularius L.) Feeding And Fecundity, Ralph B. Narain, Shripat T. Kamble

Department of Entomology: Faculty Publications

Bed bugs are ectoparasites of humans and require a blood meal for their growth and reproduction. Since humans consume Ibuprofen as pain medication and drink coffee (caffeine), bed bugs are likely to acquire these drugs through blood feeding. In this study, we determined the biological effects of Ibuprofen and caffeine on bed bug feeding, fecundity and egg hatch. Five concentrations of Ibuprofen and caffeine were incorporated into reconstituted human blood (RHB). Control treatment had no Ibuprofen or caffeine. Each treatment had six replications. Groups of 20 adult bed bugs (10 males: 10 females)/treatment/replication were pre-weighed, allowed to feed for 45 …

Genetic And Cellular Studies Of The Podocyte In Focal Segmental Glomerulosclerosis, Haiyang Yu

Arts & Sciences Graduate Student Theses and Dissertations

The podocyte forms the outer layer of the filtration barrier in the glomerulus to prevent albumin leakage. Podocyte damage leads to focal segmental glomerulosclerosis (FSGS), a leading cause of chronic kidney disease. The cause of the majority of FSGS cases is unknown and referred to as sporadic FSGS. Genetic studies have identified genes as monogenic causes of FSGS in patients with a strong family history, but these cases account for only a small proportion of the FSGS population. Whether genetic susceptibility contributes to sporadic FSGS and which cellular process in the podocyte initiates the pathogenesis of FSGS are important questions …

Maternal Obesity And Incidence Of Depression, Caroline A. Habjan

Renée Crown University Honors Thesis Projects - All

Obesity is a national epidemic in the United States, which both directly and indirectly affects the social productivity of individuals, the American macro economy and individuals’ personal health and well being. Depression often interferes with an individual’s ability to work, sleep, study, eat, and enjoy life. A maternal state of both obesity and depression may cause serious adverse medical conditions in the mother’s child. Taking steps to treat depression and obesity are critical in the construct of modern medicine. This project yields results that have the potential to make treatment options better tailored, more efficient, effective and economically-sound for the …

Determining The Daily Caloric Needs Of Collegiate Female Athletes, Alicia D. Watson

Theses

Dietary requirements in athletes are critical to overall health and performance, yet no formula to predict dietary needs is available for female athletes. This study's purpose was to develop a validated prediction equation to predict the resting metabolic needs of female athletes. 63 NCAA Division II female athletes (19.7 ± 1.1 years, 169.3 ± 8.6 cm, 67.5 ± 9.1 kg) were recruited as participants in this study. Upon providing their informed consent, study participants arrived for testing in the morning between the hours of 0600 - 1000 after observing a ~10 hour fast and within 30 - 60 minutes of …

Pregenomic And Genomic Effects Of 24,25-Dihydroxyvitamin D3, Yang Zhang

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

In the United States, the major dietary source of protein is poultry meat, particularly chicken. Phosphorus absorption in chickens is a critical problem in poultry production. It therefore is important to understand the cellular and molecular regulation of phosphorous absorption in intestine to increase efficiency of the process. This would provide the benefits of reducing feed costs and reducing phosphorous excretion, thereby contributing to the sustainability of agriculture in the United States. Therefore, the focus of this thesis is determining the effect of vitamin D metabolites involved in phosphate homeostasis using the chicken as a model.