Digital Commons Network^™

Renal Patients’ Perception Of Self-Efficacy Through Rapport And Trust With Registered Dietitians, Michelle Denise Broussard

Walden Dissertations and Doctoral Studies

End stage renal disease requires dietary education and behavior modifications to manage the condition. The purpose of this quantitative study was to investigate the role of rapport and trust between the patients and registered dietitians and its impact on self-efficacy. The study was implemented over 12 weeks in multi-site dialysis units in urban Georgia. The health belief model was used as the framework to explain the participants’ desire toward self-efficacy. Data were obtained for the 14-item Health Care Relationship Trust scale and the self-efficacy scales and analyzed using multiple linear regression. A convenience sample of 125 patients between the ages …

Multicomponent Parenteral Lipid Emulsions Do Not Prevent Liver Injury In Neonatal Pigs With Obstructive Cholestasis, Greg Guthrie, Caitlin Vonderohe, Valeria Meléndez Hebib, Barbara Stoll, Douglas Burrin

Children’s Nutrition Research Center Staff Publications

Biliary atresia (BA) is a pediatric liver disease that often necessitates parenteral nutrition (PN) to support growth due to impaired liver function. While soy-based lipid emulsions (SLE) are commonly used in PN, they may contribute to cholestatic liver injury. In contrast, mixed lipid emulsions (MLE) show promise in preventing cholestasis in infants without BA, potentially by restoring bile flow. However, their effectiveness in patients of complete bile duct obstruction, as seen in BA, remains uncertain. To explore the potential benefits of MLE in BA, we utilized a neonatal pig model of bile duct ligation (BDL). Pigs underwent either BDL or …

The Joint Association Of Diet Quality And Sleep Regularity With Incident Cardiovascular Disease In The Multi-Ethnic Study Of Atherosclerosis, Kaitlin S Potts, Claire Veldkamp, Alexis C Wood, Erin D Michos, Raymond Noordam, Tianyi Huang, Susan Redline, Heming Wang

Children’s Nutrition Research Center Staff Publications

Background/objectives: Diet quality and sleep regularity both influence cardiovascular disease (CVD) risk and may influence each other, but there is scarce evidence for their joint or interacting associations in relation to CVD. We assessed these associations in the Multi-Ethnic Study of Atherosclerosis (MESA).

Methods: Participants free of CVD with valid diet and sleep measures in 2010-2013 were included and followed through 2020 for detection of incident CVD (188 events detected over 8.8 years among 1782 participants; 55% women). Sleep timing and duration regularity were assessed via the intra-individual SD of sleep onset time and duration across 5- to 7-day actigraphy. …

Predicting Pathologic ≥N2 Disease In Women With Breast Cancer, Kerollos Nashat Wanis, Wenli Dong, Yu Shen, Funda Meric-Bernstam, Taiwo Adesoye, Abigail S Caudle, Sarah M Desnyder, Susie X Sun, Isabelle Bedrosian, Puneet Singh, Solange E Cox, Kelly K Hunt, Rosa F Hwang

Faculty, Staff and Student Publications

The distinction between pN1 and ≥pN2 breast cancer impacts treatment decisions. Using data from a single institution on women with cN0 invasive breast cancer who were treated with upfront surgery, had 1-3 positive SLNs, and underwent completion ALND, we used gradient boosted trees (XGBoost) to develop a model for predicting ≥pN2 disease using clinicopathologic variables. Model performance was tested in a held-out subsample (20%) and validated using data from the National Cancer Database (NCDB). Of 3574 patients with cN0 breast cancer, 587 underwent upfront surgery and had 1-3 positive SLNs. Of these, 415 (70.7%) underwent completion ALND, with 64 (15.4%) …

It Is Not Clear How Well Physical Activity Promotion Materials Are Understood: Findings From A Rapid Literature Review, Jafra D. Thomas, Jasmine C. Wong, Regina F. Hockert, Yi Sheng Wu, Winston Kennedy

Topics in Exercise Science and Kinesiology

Topics in Exercise Science and Kinesiology Volume 6: Issue 1, Article 6, 2025. Efforts to promote physical activity and other health-related behaviors are more effective when resource materials are understood by a wide and diverse audience. Before our lab’s previous investigations (Thomas et al., 2024), only one study seemed to use the cloze procedure to directly test the comprehension (i.e., readability) of physical activity promotion material (Cardinal & Seidler, 1995). Thus, this rapid literature review sought to (a) determine the extent the cloze procedure has been used to study physical activity promotion material comprehension in lay adults and (b) collate …

Getting The Most Out Of Your Maternity Leave, Joey Averett

Family Perspectives

No abstract provided.

Poverty In Association To Academic Achievement In Children, Sara Tolley

Family Perspectives

This paper explores the impact of poverty on academic achievement in children. It begins by outlining the general effects of poverty before delving into its specific consequences for educational outcomes. Findings indicate that poverty significantly affects self-esteem and family relationships, which, in turn, contribute to lower academic performance among children. Additionally, the paper proposes underlying causes for these outcomes and potential interventions. These insights are supported by a diverse range of data, highlighting the urgent need to address this critical issue.

The Relationship Between Immigration And Academic Achievement In Hispanic Children, Jasmine Selph

Family Perspectives

This literature review explores the relationship between immigration and academic achievement among Hispanic immigrant children in the United States, focusing on the impacts of immigration trauma and poverty. With immigration levels reaching record highs, Hispanic immigrant children face unique challenges that significantly influence their educational outcomes. Research highlights the profound effects of immigration trauma, including familial separation, violence, and insecurity, which manifest in physical, emotional, and cognitive difficulties that hinder academic performance. Additionally, poverty compounds these challenges, creating barriers to educational success through limited resources, language acquisition difficulties, and intergenerational cycles of disadvantage. The review also examines the roles of …

Suicidal Ideation Of Queer Adolescents, Haley Kamikawa

Family Perspectives

Suicide is the second leading cause of death in youth ages 15-29 around the world. This literature review examines some of the reasons why adolescents are likely to experience suicidal ideation and emphasizes why queer adolescence are at a much greater risk for suicidal ideation (Li Kitts, 2005; McDermott et al., 2018; Wichstrøm & Hegna, 2003). Bullying and lack of parental support were found to be the greatest contributors for queer adolescence experiencing suicidal ideation (Czyz et al., 2018; Sultana et al., 2023; Wedell, 2024). Bullying and lack of parental acceptance has been found to increase levels of emotional distress …

The Menstrual Cycle And Relationships, Anna Stewart

Family Perspectives

No abstract provided.

Parental Media Moderation: How Parents Can Help Their Children Navigate Digital Media, Allison Rowberry

Family Perspectives

This essay explores the impact of electronic media on children’s behavior and the critical role of parental mediation in shaping media consumption. With nearly universal access to mobile and touchscreen technology among adolescents, excessive media use has become a pressing concern, often exceeding the recommended limits set by the American Academy of Pediatrics (e.g., Gentile et al., 2012). The literature review investigates three primary parental mediation styles: restrictive mediation, active mediation, and co-viewing, each with distinct implications for child development. Restrictive mediation sets limits on content and time, potentially fostering negative outcomes when autonomy is disregarded. Active mediation emphasizes open …

Nebraska Farm Finances In 2024: A Year Of Modest Recovery And Growing Financial Pressure, Tina N. Barrett

Cornhusker Economics

Nebraska Farm Finances in 2024: A Year of Modest Recovery and Growing Financial Pressure by Tina N. Barrett (Cornhusker Economics, May 21, 2025)

Section headers:

Net Income Recovery Falls Short of Historical Highs

Household Spending Steady Amid Income Fluctuations

Rising Debt and Shifting Balance Sheets

Liquidity Pressures Worsen

Interest Costs Add to Financial Strain

Capital Purchases Shift: Less Equipment, More Land

Crop Enterprise Analysis: Losses Mount Despite Input Savings

Crop Enterprise Analysis: Losses Mount Despite Input Savings

Exposure To Second-Hand Smoke In Homes And Respiratory Symptoms Among Non-Smoking Adults In Depok, Indonesia 2025, Faraz Ali, Budi Hartono

Journal of Indonesian Health Policy and Administration

Second-hand smoke (SHS) exposure in the home environment has become a public health emergency, especially in countries with very high smoking rates, such as Indonesia. SHS exposure has already presented evidence of symptoms of the respiratory category, like a cough and shortness of breath. This study aimed to assess the association between exposure to SHS at home and the presence of respiratory symptoms among non-smoking adults in Depok, Indonesia. Convenience sampling was adopted for enrolling 108 non-smoking adults aged 18-30 who were jointly exposed to SHS in their homes for a cross-sectional study. Data aggregations of gatherings were performed using …

Global Dna Methylation Differences Involving Germline Structural Variation Impact Gene Expression In Pediatric Brain Tumors, Fengju Chen, Yiqun Zhang, Wei Li, Fritz J Sedlazeck, Lanlan Shen, Chad J Creighton

Children’s Nutrition Research Center Staff Publications

The extent of genetic variation and its influence on gene expression across multiple tissue and cellular contexts is still being characterized, with germline Structural Variants (SVs) being historically understudied. DNA methylation also represents a component of normal germline variation across individuals. Here, we combine germline SVs (by short-read sequencing) with tumor DNA methylation across 1292 pediatric brain tumor patients. For thousands of methylation probes for CpG Islands (CGIs) or enhancers, rare and common SV breakpoints upstream or downstream associate with differential methylation in tumors spanning various histologic types, a significant subset involving genes with SV-associated differential expression. Cancer predisposition genes …

Comparing Performance Of Aquaponics Systems Using Different Designs And Fish Feeds, Cody G. Willmore

Biology Theses, Dissertations, and Student Creative Activity

Future food production requires sustainable approaches that used both land and water resources efficiently, while remaining economically viable. One approach is aquaponics, the practice which combines hydroponics and aquaculture, as a sustainable food producing system. Aquaponic systems are unique, as the system can be designed to reuse and repurpose locally sourced materials and resources to meet individual needs. However, productivity of these systems can be inefficient or inconsistent, impacting the viability of aquaponics. The first objective of my study was to compare how system design between a do-it yourself reclaimed-materials aquaponic system and a prefabricated aquaponic setup affects water quality …

Traceable And Scalable Food Balance Sheets From Agricultural Commodity Supply And Utilization Accounts (2010–2022), Xin Zhao, Maksym Chepeliev, Neus Escobar, Matthew T. Binsted, Pralit Patel, Page Kyle, Marshall A. Wise

Department of Agricultural Economics Faculty Publications

The Food Balance Sheets (FBS), compiled by the Food and Agriculture Organization (FAO), serve as a cornerstone dataset for studies on agricultural development, food security, and dietary health, providing a broad overview of global and regional food systems. However, its limited transparency and scalability hinder its application in empirical analysis and multisector dynamic modeling. Here, we present a traceable Food Balance Sheets (T-FBS) dataset, developed from detailed Supply Utilization Accounts (SUA) using a novel Primary Commodity equivalent (PCe) aggregation approach. This framework enables the aggregation of commodity flows along supply chains while ensuring consistency and balance across multiple dimensions. The …

To Diversify Or Not To Diversify: A Preliminary Report On Farmers’ Perspectives On Diversification In The U.S. Midwest, Lauren Asprooth, J. Gordon Arbuckle, Rebecca Traldi, Sarah P. Church, Kristin Floress, Benjamin M. Gramig, Andrew J. Margenot, Elizabeth Maynard, Aaron Thompson, Ariana P. Torres, Emily M. Usher, Ishraq Awashra, Katherine Pivaral, Finnleigh S, Woodings, Linda Stalker Prokopy

Department of Horticulture & Landscape Architecture Faculty Publications

Diversifying the simplified landscape of corn and soybeans in the Midwest is an emerging priority in both the public and private sectors to reap a suite of climate, social, agronomic, and economic benefits. However, little research has documented the perspectives of farmers, the primary stakeholders in diversification efforts. This preliminary report uses newly collected survey data (n = 725) from farmers in the states of Illinois, Indiana, and Iowa to provide descriptive statistics and tests to understand what farmers in the region think about agricultural diversification, including their perspectives on its benefits, barriers, and opportunities. For the purposes of the …

A Complete Transfer Learning-Based Pipeline For Discriminating Between Select Pathogenic Yeasts From Microscopy Photographs, Ryan A. Parker, Danielle S. Hannagan, Jan H. Strydom, Christopher J. Boon, Jessica Fussell, Chelbie A. Mitchell, Katie L. Moerschel, Aura G. Valter-Franco, Christopher Cornelison

Faculty Articles

Pathogenic yeasts are an increasing concern in healthcare, with species like Candida auris often displaying drug resistance and causing high mortality in immunocompromised patients. The need for rapid and accessible diagnostic methods for accurate yeast identification is critical, especially in resource-limited settings. This study presents a convolutional neural network (CNN)-based approach for classifying pathogenic yeast species from microscopy images. Using transfer learning, we trained the model to identify six yeast species from simple micrographs, achieving high classification accuracy (93.91% at the patch level, 99.09% at the whole image level) and low misclassification rates across species, with the best performing model. …

In Vivo Crispr Activation Screen Identifies Acyl-Coa-Binding Protein As A Driver Of Bone Metastasis, Hongqi Teng, Qinglei Hang, Caishang Zheng, Yuelong Yan, Shaomin Liu, Yang Zhao, Yalan Deng, Litong Nie, Weiche Wu, Marisela Sheldon, Zachary Yu, Wei Shi, Jianxuan Gao, Chenling Meng, Consuelo Martinez, Jie Zhang, Fan Yao, Yutong Sun, Di Zhao, Boyi Gan, Tong Meng, Li Ma

Faculty, Staff and Student Publications

One of the most common sites of cancer metastasis is to the bone. Bone metastasis is associated with substantial morbidity and mortality, and current therapeutic interventions remain largely palliative. Metastasizing tumor cells need to reprogram their metabolic states to adapt to the nutrient environment of distant organs; however, the role and translational relevance of lipid metabolism in bone metastasis remain unclear. Here, we used an in vivo CRISPR activation screening system coupled with positive selection to identify acyl-coenzyme A (CoA) binding protein (ACBP) as a bone metastasis driver. In nonmetastatic and weakly metastatic cancer cells, overexpression of wild-type ACBP, but …

Simultaneous Targeting Of Tumor Cells And Tumor-Associated Macrophages To Reprogram Glioblastoma Using Trypsinized Extracellular Vesicles Carrying Tumor Suppressive Microrna, Grace H Nguyen, Minhye Noh, Jin Muk Kang, Alexandra A Miller, Minxin Huang, Jeong-Yeon Lee, Hongyu Wang, George A Calin, Cynthia Ju, Holger K Eltzschig, Yeshavanth Banasavadi-Siddegowda, Zhongming Zhao, Ji Young Yoo, Tae Jin Lee

Faculty, Staff and Student Publications

Glioblastoma (GBM) remains difficult to treat due to poor drug delivery across the blood-brain barrier and an immunosuppressive tumor microenvironment (TME). Tumor-suppressive microRNAs (miRNAs) offer a promising strategy to reprogram both tumor cells and the TME, but inefficient delivery systems limit their clinical application. We previously reported that tumor-suppressive miR-138 regresses tumor growth in preclinical GBM models. Here, we demonstrate that trypsin digestion of extracellular vesicles (EVs) enhances labeling efficiency with folate (FA), enhancing selective targeting of folate receptor (FR)-positive GBM cells and enabling simultaneous targeting of tumor-associated macrophages (TAMs). FA-labeled trypsinized EVs (tEVs) loaded with miR-138 inhibit tumor growth, …

Correction: Targeting Of Epigenetic Co-Dependencies Enhances Anti-Aml Efficacy Of Menin Inhibitor In Aml With Mll1-R Or Mutant Npm1, Warren Fiskus, Christopher P Mill, Christine Birdwell, John A Davis, Kaberi Das, Tapan M Kadia, Koichi Takahashi, Sanam Loghavi, Michael J Soth, Tim Heffernan, Gerard M Mcgeehan, Xinjia Ruan, Xiaoping Su, Christopher R Vakoc, Naval Daver, Kapil N Bhalla

Faculty, Staff and Student Publications

No abstract provided.

Investigating The Role Of Lysophosphatidic Acid Receptor 3 In Ocular Surface Ion Transport And Fluid Secretion, Ethan Lindgren

Natural Sciences and Mathematics | Biological Sciences Master's Theses

Dry eye disease (DED) is a multifactorial disease that drives tear film instability and hyperosmolarity, directly damaging the ocular surface epithelium. Lysophosphatidic acid receptor (LPAR) is a G-protein coupled receptor (GPCR) responsible for Ca²⁺ and cAMP mobilization via PLC and adenylyl cyclase activation, respectively. LPAR signaling is involved in cell proliferation and wound healing in human corneal epithelial cells (HCECs) as well as in neuropathic pain. This study aims to investigate expression and functional roles of LPAR3 in ocular surface. Ocular surface potential difference (OSPD) and tear fluid volume measurements were performed in mice with topically applied LPAR modulators. …

Administering A Mitophagy Inducing Compound (Mic) To Suppress Neuropathology In A Mouse Model Of Alzheimer’S Disease, Zachary Mayeri

Natural Sciences and Mathematics | Biological Sciences Master's Theses

Despite FDA-approved amyloid-beta (Aβ) therapies in Alzheimer’s disease (AD), Tau pathology remains untreated and is closely linked to cognitive decline. Mitophagy, the process of mitochondrial degradation, is vital for maintaining neuronal health, and its dysregulation is implicated in AD. Recently, our lab identified a mitophagy inducing compound (MIC) that extends the lifespan of C. elegans. We hypothesized that MIC would significantly mitigate neuropathology in an AD mouse model. In this study, aged 3x-Tg AD mice were fed an MIC-containing diet, and immunohistochemistry (IHC) was performed on hippocampal tissue to visualize Aβ and phospho-Tau (pTau) lesions. While MIC had little …

Ion-Dna Interactions As A Key Determinant Of Uracil Dna Glycosylase Activity., Sharon N Greenwood, Alexis N Dispensa, Matthew Wang, Justin R Bauer, Timothy D Vaden, Zhiwei Liu, Brian P Weiser

Rowan-Virtua School of Osteopathic Medicine Departmental Research

Because of their ubiquitous presence, ions interact with numerous macromolecules in the cell and affect critical biological processes. Here, we discuss how cations including Mg²⁺ alter the enzymatic activity of a DNA glycosylase by tuning its affinity for DNA. The response of uracil DNA glycosylase (UNG2) to Mg²⁺ ions in solution is biphasic and paradoxical, where low concentrations of the ion stimulate the enzyme, but high concentrations inhibit the enzyme. We analyzed this phenomenon by modeling experimental data with a statistical framework that we empirically derived to understand molecular systems that display biphasic behaviors. Parameters from our statistical …

An Aquatic Treadmill Alters Lower Limb Walking Dynamics In Typically Developing Children And Children With Cerebral Palsy, Oluwaseye P. Odanye, Joseph Harrington, Aaron Likens, David Kingston, Brian Knarr

Journal Articles

This block-randomized crossover study investigated how a speed-modulated aquatic treadmill (AT) impacts the walking biomechanics of pediatric gait. Eight cerebral palsy (CP) and fifteen typically developing (TD) children walked at normal, slow, and fast treadmill speeds in AT and dry treadmill (DT) conditions. The joint angles of participants were calculated from inertial measurement units to derive sample entropy (SE) measures that quantified the regularity or complexity of motion. A hierarchical statistical model revealed that the CP group had lower SE values for the hip, knee, and ankle joints in the AT and at slower than faster treadmill speeds. Only the …

Network Analysis Of Antimicrobial Resistance In Staphylococcus Aureus: Characterization Of Hub Genes And Their Functional Implications, Md Imran Hasan, Davida Smyth, Jeong Yang, Ashley Teufel

Masters Theses (Archived)

Antimicrobial resistance is a major cause of morbidity and mortality in patients with S. aureus infections. In this study, we analyzed genes, molecular mechanisms, and pathways driving drug resistance in S. aureus using network analysis. Using whole-genome sequencing (WGS) data and systems biology approaches, we identified 229 AMR-associated genes and constructed a protein-protein interaction network among these genes. Through network topology and functional enrichment analyses, we not only confirmed their association with resistance, but also highlighted the central roles of these genes in resistance pathways, such as efflux, target replacement, and target protection, which are directly linked to multiple drug …

Discrimination Of Sprat Species (Clupeonella Spp.) In The Caspian Sea And The Sea Of Marmara Using Otolith Shape Analysis, Mohammad Reza Shariati, Mohammad Sadegh Alavi-Yeganeh, Mehdi Ghanbarifardi, Gülşah Saç, Müfi̇t Özuluğ, Erdoğan Çi̇çek

Turkish Journal of Zoology

This study evaluates the discriminating power of sagittal otolith shape among three species of the genus Clupeonella endemic to the Caspian Sea (Clupeonella grimmi, Clupeonella caspia, and Clupeonella engrauliformis) and one species from the Sea of Marmara (Clupeonella Cultriventris). Identification of these species is challenging due to their morphological similarities, and the taxonomic validity of C. caspia and C. cultriventris remains ambiguous because of their resemblance. Scanning electron microscope (SEM) images were utilized to examine the morphological characteristics of otoliths. Stereomicroscope images were used to calculate six shape indices: rectangularity, roundness, ellipticity, circularity, aspect ratio, and form factor. The outline …

Assessment Of Pyriproxyfen 0.5% (Juvenile Hormone Analog) Against Mosquito (Diptera: Culicidae) Larvae: A Multiscale Study From Laboratory To Field, Neetu Kachhwaha, Vinod Kumari, Rajbala Verma, Nirmala Sharma, Asif Khan, Mohit Singh, Sanyam Nimoria, Priyadarshini Sharma

Turkish Journal of Zoology

Vector control strategies increasingly focus on nonconventional chemicals with high insecticidal efficacy, persistence, and low toxicity to nontarget organisms. The present multiphase study, conducted in laboratory, semifield, and field conditions in Jaipur, Rajasthan, India, evaluated the efficacy of pyriproxyfen (0.5%) (juvenile hormone analog) in controlling mosquito emergence. Laboratory bioassays demonstrated significant susceptibility of Culex tritaeniorhynchus Giles, 1901 (Diptera: Culicidae) larvae, with the first and second instars exhibiting 100% mortality at 1 ppm and third and fourth instars showing emergence inhibition (IE) of 86.11% and 65.28%, respectively. Probit analysis determined lower LC₅₀, LC₉₀, and LC₉₉.₉ values for the first instar larvae …

Histone Methyltransferase Ash1l Primes Metastases And Metabolic Reprogramming Of Macrophages In The Bone Niche, Xinhai Wan, Anna Debruine, Yin Wang, Xin Liang, Javier Leo, Feiyu Chen, Qianlin Gu, Jie Zhang, Vivien Van, Kiersten L Maldonado, Boyi Gan, Li Ma, Yue Lu, Di Zhao

Faculty, Staff and Student Publications

Bone metastasis is a major cause of cancer death; however, the epigenetic determinants driving this process remain elusive. Here, we report that histone methyltransferase ASH1L is genetically amplified and is required for bone metastasis in men with prostate cancer. ASH1L rewires histone methylations and cooperates with HIF-1α to induce pro-metastatic transcriptome in invading cancer cells, resulting in monocyte differentiation into lipid-associated macrophage (LA-TAM) and enhancing their pro-tumoral phenotype in the metastatic bone niche. We identified IGF-2 as a direct target of ASH1L/HIF-1α and mediates LA-TAMs' differentiation and phenotypic changes by reprogramming oxidative phosphorylation. Pharmacologic inhibition of the ASH1L-HIF-1α-macrophages axis elicits …

A Singular Case Of Early-Stage Long-Distance Dispersal Of The Smooth Newt, Lissotriton Vulgaris (Linnaeus, 1758) (Amphibia, Caudata), Simone Costa, Francesco Paolo Faraone, Mario Lo Valvo

Turkish Journal of Zoology

To date, the global introduction of alien amphibians and reptiles has likely been facilitated by the expanding plant nursery trade. Here, we report in detail a singular case of unintentional introduction of Lissotriton vulgaris in Sicily. A newt in the final stages of its larval development was found in a private garden pond in north-western Sicily, where aquatic plants from a nursery in Veneto (northeastern Italy) had been introduced two months earlier. The analysis of the mithochondrial markers ND2 and ND4 revealed a shared haplotype between the Sicilian newt and a sample from Treviso, the province of the putative source. …