Digital Commons Network^™

The Native And Introduced Bark And Ambrosia Beetles Of Michigan (Coleoptera: Curculionidae, Scolytinae), Anthony I. Cognato, Nicolas Barc, Michael Philip, Robert Mech, Aaron D. Smith, Eric Galbraith, Andrew J. Storer, Lawrence R. Kirkendall

The Great Lakes Entomologist

Our knowledge of the biogeography of Scolytinae of eastern temperate North America is very patchy. We used data from hand collecting, trapped material (from 65 of 83 counties), and museum collections, supplemented by literature records, to compile a list comprising 107 bark beetle species in 45 genera for Michigan, a state with an especially rich diversity of woody plants. We provide detailed collection data documenting 32 species not previously catalogued for Michigan, 23 of which are new state records; the genera Trypophloeus and Trischidias are reported from Michigan for the first time. Fifteen Michigan scolytines are not native to North …

Fleas Of The Norway Rat In The Superior, Wisconsin, Harbor Area (Siphonaptera: Ceratophyllidae, Hystrichopsyllidae), Darol L. Kaufmann, Norman D. Radtke

The Great Lakes Entomologist

The occurrence of the fleas of the Norway rat, Rattus noruegicus (Berkenhout) was monitored in Superior, Wisconsin, for 12 months. A total of 441 fleas was recovered from 300 rat hosts. Nosopsyllus fasciatus (Bosc), the northern rat flea, was the most abundant species found (94.1%) while Ctenophthalmus pseudagyrtes pseudagyrtes Baker (5.4%) and Megabothris asio asio (Baker) (0.5%) were also present. The flea index was highest (4.8) in July and lowest (0.2) in February and March. Forty-four percent of the rats examined were infested.

The Possible Cardioprotectiveeffect Of Empagliflozin During Endotoxemia In Mice Model, Safwa Miqdad Al-Killidar, Bashaer M. Muhammad-Baqir

Maaen Journal for Medical Sciences

Background:Sepsis is a major complication for seriously ill people with shock, major infections, serious burns, or severe trauma. Inflammation imbalance is the primary underlying cause of sepsis progression and persists continuously over the entire sepsis course. Empagliflozin is an orally administered medication for diabetes that selectively inhibits sodium-glucose cotransporter 2 to improve kidney elimination of glucose. It has been discovered that sodium-glucose cotransporter 2 exhibit anti inflammation and multiple effects, suggesting that they may be beneficial and prevent infections. Aim of study:This study was undertaken to assess Empagliflozin's cardioprotective efficacy in septic mice through its potent anti- inflammatory …

Seroprevalence And Associated Risk Factors Of Caprine Arthritis Encephalitis (Cae) And Peste Des Petits Ruminants (Ppr) Among Deer In An Institutional Farm In Malaysia, Krishnan Nair Balakrishnan, Faez Firdaus Abdullah Jesse, Bura Thlama Paul, Shalonagiftsal Stephen C Charles, Ummul Rifhan Najiha Noor Zaman, Eric Lim Teik Chung, Nur Amira Azhar, Abdirahman Barre, Muhammed Mikail, Mohd Azmi Mohd Lila

The Thai Journal of Veterinary Medicine

Caprine arthritis encephalitis (CAE) and peste des petits ruminants (PPR) are significant viral diseases impacting small ruminants, leading to substantial economic losses and posing a potential threat to livestock health. Although seroprevalence evidence of these viruses has been documented in ruminants, there is a lack of data regarding their presence among farmed deer in Malaysia. This preliminary study aimed to determine the seroprevalence and associated risk factors for CAEV and PPRV infections among deer in Malaysia. A total of ninety-two blood sera from an institutional deer farm were screened for CAEV and PPRV antibodies using commercially available indirect ELISA test …

Four Synonyms Of Tetraleurodes Mori (Quaintance, 1899) (Hemiptera: Sternorrhyncha: Aleyrodidae), Natalia Von Ellenrieder, Raymond J. Gill, Ian C. Stocks

Insecta Mundi

Examination of type specimens of Aleyrodes errans Bemis, 1904, A. dorseyi Kotinsky, 1907 (replacement name for A. quaintancei Bemis, 1904), and A. splendens Bemis, 1904 and comparison with a large series of specimens of Tetraleurodes mori (Quaintance, 1899) (Hemiptera: Sternorrhyncha: Aleyrodidae) confirms that the first four names represent new junior subjective synonyms of the latter species, since their types do not differ from it in any significant way and display the combination of diagnostic characters that identifies that species.

Resumen

El análisis de ejemplares tipo de Aleyrodes errans Bemis, 1904, A. dorseyi Kotinsky, 1907 (nombre de …

Learning That Sticks: How Students Remember Invasive Species Through Different Learning Methods, Francesco L. Miniello

Honors College Theses

This study aimed to determine which learning methods are most effective at helping students learn about invasive species. Research through literature reviews showed that active learning methods can best help students learn and retain information regarding aspects of the natural environment. This includes hands-on activities such as participating in discussions, making observations, playing games, and interacting with objects like animals. The experiment tested different active and passive learning methods. This included watching presentations under passive learning or reviewing information online through active learning. Results showed that participants felt more confident about learning the material through active learning and were more …

Examining The Influence Of Vision And Change And A Mentoring Network On Teaching Philosophies And Strategies, Stephanie Mathews, Carlos C. Goller, Michael J. Wolyniak, Uma Swamy, Anjali Misra, Michael E. Moore, Jeremy L. Hsu, Dina L. Newman

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

The 2011 report Vision and Change: A Call to Action (V&C) resulted from a national effort to rethink biology curriculum. V&C outlines core concepts and core competencies for biology undergraduates and promotes evidence-based pedagogy, undergraduate research, and inclusive practices. However, it is unclear how much biology educators know about V&C and what motivates educators’ development of their teaching philosophy and practices. We leveraged the Promoting Active Learning and Mentoring (PALM) Network, a group that introduced evidence-based instructional practices (EBIPs) to instructors through mentoring, journal clubs, and a community of practice, to investigate how much V&C has influenced educator …

Neovascular Pruning By Ido1 Inhibitors Can Potentiate Immunogenic Cytotoxicity Of Ischemia-Targeted Agents To Synergistically Enhance Anti-Pd-1 Responsiveness, Shih-Chun Shen, Souvik Dey, James B. Duhadaway, Erika Sutanto-Ward, Maurice T. Hampton, Serguei V. Kozlov, George C. Prendergast, Alexander J. Muller

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

BACKGROUND: Strategies for deploying indoleamine 2,3-dioxygenase 1 (IDO1)-targeted therapies for use against cancer have focused on IDO1's role in promoting peripheral immune tolerance that shields tumors from effector T cells. However, preclinical investigation of both primary and metastatic tumor development in the lungs has uncovered a previously unappreciated role for IDO1 in directing a counterregulatory response to interferon (IFN)-γ that realigns the local inflammatory environment to promote tumor neovascularization. Understanding how to therapeutically leverage the ability of IDO1 inhibitors to subvert inflammatory neovascularization within the tumor microenvironment has potential ramifications for future clinical development of these compounds.

METHODS: Pulmonary metastases …

Social Eating Role In Ultra-Processed Food Consumption Among Urban Young Adults: The 2018 Indonesian Food Barometer, Imas Arumsari, Nabilla Ayusyah Putri, Siti Nur Lulu Lathifah, Gita Aisyah Astrid Rosalba, Helda Khusun, Judhiastuty Februhartanty, Rahmatika Nur Aini

Kesmas

This study investigated the differences in ultra-processed food (UPF), fruit, vegetable, and total fat consumption in different aspects of social eating among urban young adults. This cross-sectional study used the 2018 Indonesian Food Barometer dataset with 180 participants aged 18–25 years living in urban areas from 6 provinces in Indonesia. The data on social eating (cooking habits, eating out, and eating alone), UPF, fruits, and vegetables were obtained from an extended 24-hour food recall interview. The Mann-Whitney U test (CI 95%) was employed for data analysis. This study found that groups with less frequent cooking habits tended to have more …

A New Genus And New Synonyms For Liburnia Reducta Van Duzee, 1907 (Hemiptera: Auchenorrhyncha: Delphacoidea: Delphacidae), Charles R. Bartlett, Adam M. Wallner

Insecta Mundi

The delphacid species Liburnia reducta Van Duzee is transferred to the new genus Calkinodelphax Bartlett and Wallner (Hemiptera: Auchenorrhyncha: Delphacoidea: Delphacidae) and is designated the type species of this genus under the name Calkinodelphax reductus (Van Duzee), new combination. Calkinodelphax reductus is broadly distributed from Florida, the Antilles, Central America, and northern South America. Calkinodelphax reductus is the subjective senior synonym of Pissonotus striolus Osborn, Delphacodes cornuta Beamer, and Euides fasciatella auct. (nec. Osborn). A new lectotype is designated for Liburnia reducta Van Duzee. The female holotype and male allotype of Liburniella fasciatella Osborn were reviewed and found to …

The Tweak/Fn14 Signaling Mediates Skeletal Muscle Wasting During Cancer Cachexia, Meiricris Tomaz Da Silva, Anirban Roy, Anh Tuan Vuong, Aniket S Joshi, Cristeena Josphien, Sajedah M Hindi, Ashok Kumar

Faculty, Staff and Student Publications

Cancer cachexia is a multifactorial syndrome characterized by progressive skeletal muscle wasting. The TWEAK-Fn14 system regulates muscle mass in diverse conditions. However, its role in the regulation of muscle mass during cancer cachexia remains less understood. Here, we demonstrate that the levels of Fn14 are induced in skeletal muscle of multiple mouse models of cancer cachexia. Muscle-specific deletion of Fn14 reduces myofiber atrophy in mouse models of pancreatic and lung cancer cachexia. Silencing of Fn14 in KPC pancreatic cancer cells prior to their implantation in mice attenuates tumor growth without affecting myofiber size. Muscle-specific deletion of Fn14 reduces the gene …

Identification Of Loci And Candidate Genes Associated With Arginine Content In Soybean, Jiahao Ma, Qing Yang, Cuihong Cu, Zhi Liu, Xiaolei Shi, Xintong Wu, Rongqing Xu, Pengshuo Shen, Yuechen Zhang, Ainong Shi, Long Yan

Horticulture Faculty Publications and Presentations

Soybean (Glycine max) seeds are rich in amino acids, offering key nutritional and physiological benefits. In this study, 290 soybean accessions from the USDA Germplasm Collection based in Urbana, IL Information Network (GRIN) were analyzed. Four Genome-Wide Association Study (GWAS) models-Bayesian-information and Linkage-disequilibrium Iteratively Nested Keyway (BLINK), Mixed Linear Model (MLM), Fixed and Random Model Circulating Probability Unification (FarmCPU), and Multi-Locus Mixed Model (MLMM)-identified two significant Single Nucleotide Polymorphisms (SNPs) associated with arginine content: Gm06_19014194_ss715593808 (LOD = 9.91, 3.91% variation) at 19,014,194 bp on chromosome 6 and Gm11_2054710_ss715609614 (LOD = 9.05, 19% variation) at 2,054,710 bp on chromosome 11. Two …

Encapsulation Of Lactobacillus Reuteri Dsm 17938 In W/O/W Emulsion: Influence Of Oil Type On Viability And Oxidative Stability, Nora Alantali

Thesis/ Dissertation Defenses

Probiotics, known for its wide range of health benefits, have been gaining recognition on its effect on the gut-brain axis. This axis, operated via various pathways, can be modulated by the type and functions of probiotics found in the gut microflora. Lactobacillus are probiotics commonly found residing in the gut and have been extensively used in food for its health benefits. However, probiotics face several stress factors before reaching the gut which hinders it from being functional. The main objective of this thesis is to construct a stable double-emulsion-based delivery system for the probiotic, which will act as a barrier …

Russell’S Viper Envenomation: The Challenge Of Diagnosis, Jing-Hua Lin, Wang-Chou Sung, Jiunn-Wang Liao, Dong-Zong Hung

BioMedicine

Russell’s viper envenomation is rare in Taiwan, and its typical clinical presentations, including consumption coagulopathy, acute renal failure, haemolysis, and increased capillary permeability, have been reported in the literature as case reports or series. Here, we report a case with an atypical presentation, and suspected to be a Russell’s viper bite due to the distinct characteristics of the snake and some progressive clinical signs/symptoms. He returned to health successfully after the correct antivenom was administered, and envenomation was ultimately confirmed by venom detection in the patient’s serum and urine samples.

Neurenteric Cysts: A Neurosurgical Case Series And Treatment Perspectives, Defran Ercan, Walter Stummer, Maryam Khaleghi Ghadiri

BioMedicine

Neurenteric cysts (NC) are rare lesions of endodermal origin lined by mucin-secreting cuboidal or columnar epithelium of an intestinal or respiratory type. They occur more frequently spinally than cranially. From the radiological view, NC may be confused with other lesions of the central nervous system, like arachnoid or epidermoid cysts. However, due to advances in neuroimaging, there is an increasing trend in preoperative diagnosis of NC. We are reporting three cases of NC, each exhibiting markedly distinct symptoms and postoperative courses. The first patient, a 45year-old woman, had NC in the fourth ventricle. Although she underwent surgery, the lesion recurred …

A Staged-Olif Approach Can Minimize Construct Lengths In Adult Spinal Deformity- A Case Series And Literature Review, Guna Pratheep Kalanchiama, Alexander Shao-Rong Pang, Jacob Yoong-Leong Oh

BioMedicine

Background:

Adult Spinal Deformity (ASD) is one of the challenging conditions to treat for spine surgeons. One of the important dilemmas in the management of these patients is the decision on the number of levels of instrumentation and the overall length of the construct. OLIF has the advantage of providing a minimally invasive approach to address this complex pathology also allowing us to stage the procedure and thus help clinicians reassess if the patient requires an additional decompression, long fusion lengths, or need for osteotomies.

Aim:

Our study aims to evaluate the possibility of minimizing the construct length following a …

Cyclohexylamine, The Principal Metabolite Of Cyclamate, Contracts The Epididymal Vas Deferens Of Rats By Affecting Endogenous Catecholamine Release Via Postsynaptic Α1aand Presynaptic Α2-Adrenoceptors In A Calcium-Dependent Manner, Yuh-Fung Chen, Yu-Wen Wang, Huei-Yann Tsai

BioMedicine

Background: Cyclohexylamine (CHA) is a principal metabolite of cyclamate, which was once one of the most prominently consumed non-sugar sweeteners. Earlier studies suggested that long-term use of cyclamate might be carcinogenic and genotoxic; however, no consistent evidence supports an association between cyclamate and cancer risk. However, this issue remains interesting. Cyclamate can be metabolized to CHA by the intestinal bacteria in humans and some animals. Previous reports indicated CHA could induce atrophy of rat testes and affect rat fertility, as well as contract rat vas deferens. However, the contractile mechanisms of CHA on rat vas deferens remains poorly understood. This …

Nutraceutical Benefits And Neuro-Protective Potent Of Four Colored Peppers (Capsicum Annuum Var. Grossum), Ya-Chen Yang, Chih-Lung Lin, Mei-Chin Yin

BioMedicine

Background: Four colored peppers (Capsicum annuum var. grossum), orange, purple, yellow and red, are plant foods served as salad or stir-fry for meals in Taiwan and many countries.

Purpose: This study aimed to investigate the multiple nutraceutical properties of aqueous extracts prepared from colored peppers.

Methods: Vitamin C content and phytochemical profiles of these peppers were analyzed. In vitro effects of anti-oxidative, anti-a-amylase, anti-a-glucosidase, antilipase and anti-acetylcholinesterase (AchE) of pepper aqueous extracts at 0.25, 0.5 and 1 mg were evaluated. The neuronal protective potent of pepper aqueous extracts at 0.5 and 1 mg in high glucose treated nerve growth factor …

The Protective Role Of Astaxanthin Against Oxidative Stress And Inflammation In Peritoneal Dialysis Rats, Ratih Tri Kusuma Dewi, Bambang Purwanto, Brian Wasita, Vitri Widyaningsih

BioMedicine

Background: Prolonged exposure of peritoneal membrane to dialysate solution is known to cause fibrosis mediated by imbalanced inflammatory response and oxidative stress. In this context, proinflammatory cytokines including TGF-β and IL-1β, along with oxidative stress markers namely SOD and MDA, present in circulation, could serve as indicators of fibrosis. This phenomenon has the potential to interfere with the optimization of Chronic Kidney Disease (CKD) treatment. Other oral antioxidant supplements have been widely studied to prevent peritoneal damage, but investigations regarding Astaxanthin (AST) effect on fibrosis marked with proinflammatory cytokine are still limited.

Aims: This study aimed to investigate the protective …

Structural And Functional Lessons Learned About Regulation Of Enterotoxigenic E. Coli Virulence Regulatory Factor, Rns, Jessica Dianne Tolbert

Dartmouth College Ph.D Dissertations

Antibiotic resistance has exacerbated the global health crisis of diarrheal diseases caused by enteric bacterial pathogens. Investigating pathogens, such as Enterotoxigenic Escherichia coli (ETEC) and Vibrio cholerae (cholera), helps to uncover mechanisms for the inhibition of virulence gene expression. A notable member of the AraC transcription factor family in ETEC, Rns, regulates virulence factors including pili and fimbriae, which are essential for adherence and colonization of the intestinal epithelial layer. This microbe–host interaction initiates the release of toxins, leading to the water and ion loss in clinically diagnosed as diarrhea.

In the canonical N-terminal domain of Rns, mutagenesis of the …

Integrating Radiogenomics And Machine Learning In Musculoskeletal Oncology Care, Rahul Kumar, Kyle Sporn, Akshay Khanna, Phani Paladugu, Chirag Gowda, Alex Ngo, Ram Jagadeesan, Nasif Zaman, Alireza Tavakkoli

Department of Medicine Faculty Papers

Musculoskeletal tumors present a diagnostic challenge due to their rarity, histological diversity, and overlapping imaging features. Accurate characterization is essential for effective treatment planning and prognosis, yet current diagnostic workflows rely heavily on invasive biopsy and subjective radiologic interpretation. This review explores the evolving role of radiogenomics and machine learning in improving diagnostic accuracy for bone and soft tissue tumors. We examine integrating quantitative imaging features from MRI, CT, and PET with genomic and transcriptomic data to enable non-invasive tumor profiling. AI-powered platforms employing convolutional neural networks (CNNs) and radiomic texture analysis show promising results in tumor grading, subtype differentiation …

Physiological And Biomechanical Responses To Indoor Cycling With And Without The Ability To Sway, Alina P. Swafford, James W. Navalta, Julia Freedman Silvernail, Nancy Lough, John A. Mercer

International Journal of Exercise Science

International Journal of Exercise Science 18(7): 531-542, 2025. The purpose of this study was to understand whether or not physiological and biomechanical measures were influenced by cycling sway and intensity. Participants (n=13; 24.9±6.5 years; 1.7±0.1 m; 64.7±11.2 kg) completed two submaximal-effort cycling conditions using a stationary smart bike placed on a rocker board: 1) cycling with the rocker board set to allow sway (unblocked); 2) cycling with blocks placed in the rocker board to prevent sway (blocked). The order conditions were counterbalanced, and each condition was 12-mins. For each condition, four intensity levels were completed. Prior to testing, target power …

The Role Of G6pd Variants And 3d Genomic Structure In The Development Of Pulmonary Hypertension, Christina M. Signoretti Ph.D.

NYMC Student Theses and Dissertations

Pulmonary hypertension is an under-recognized global health epidemic which is estimated to affect 1% of the population. It is associated with sustained mean pulmonary artery pressure greater than 20 mmHg, pulmonary artery remodeling, smooth muscle and endothelial cell proliferation and subsequent increased right ventricle hypertrophy due to increased afterload. Glucose-6-phosphate dehydrogenase (G6PD) is one of the key enzymes in the pentose phosphate pathway and has been previously linked to the development of pulmonary hypertension. G6PD deficiency is the most common human enzymopathy which affects approximately 400 million people worldwide and is a result of agricultural and epidemiological evolution in different …

The Effects Of Morphine, Thc, And Lsd On Synaptic Plasticity Of The Ventral Tegmental Area, Michael Von Gunten

Theses and Dissertations

The brain is an intricate network of neurons that communicate via synapses. Synaptic plasticity, which is the ability to strengthen or weaken synaptic connections, plays a key role in learning, memory, and reward learning. Disruptions to synaptic plasticity play a central role in addiction, particularly in brain circuits involved in reward and motivation. The mesolimbic reward system, which includes the ventral tegmental area (VTA) and its dopaminergic projections, is a primary target of drugs of abuse, including opioids and cannabinoids. However, the physiological consequences of combined exposure to opioids and cannabinoids and the potential for psychedelics to reverse drug-induced neuroadaptations …

Physical Activity And Body Image In Early Onset Cancer Patients, Madeleine Z. Pollard

Graduate Masters Theses

Abstract: Cancer is the leading cause of death among Americans under the age of 85 (Brown et al., 2012). There are increasing rates of cancer diagnoses in adults aged 18-49, which is described as an early onset (EO) diagnosis. Despite high survival rates (Lewis et al., 2021), EO cancer patients are at increased risk for long-term physical and psychological challenges associated with both the disease and its treatment (Haque et al., 2023). Cancer diagnosed during these critical periods of life can significantly impact self-perception and body image, which are critical to identity formation and quality of life (Castonguay, et al., …

From Epidemics To Experimental Treatments: Amphibian Mass Mortality Events And A Potential Treatment For Chytridiomycosis, Daniel Callahan

Graduate Masters Theses

Worldwide, amphibian populations have experienced dramatic declines due to a variety of threats. Among them, disease has been particularly deleterious and continues to impact populations. In the United States and Canada, the three leading causes of amphibian mass mortality events are ranavirosis, chytridiomycosis, and severe perkinsea infection, all caused by infectious pathogens. While research and policy have helped populations recover from these diseases, more work needs to be done to develop practical and efficient treatments for these infections. Of these three diseases, chytridiomycosis has had the most devastating effects on amphibian populations globally. Caused by the chytrid fungi Batrachochytrium dendrobatidis …

Mechanisms Of Placental Impairment And The Upregulation Of Fetuin-B During Maternal Undernourishment, Mia Camilliere

NYMC Student Theses and Dissertations

Proper nutrition is crucial during pregnancy to support fetal and placental development. Failure to meet these nutritional needs can result in adverse health outcomes for both mother and baby. Despite its high prevalence in underdeveloped countries, maternal undernourishment is a public health issue worldwide. There are several possible causes of maternal undernourishment, and these can occur alone or in combination, such as poor access to nutrition, hyperemesis gravidarum, and drug use. This condition can adversely affect placental development and function to the extent of placental insufficiency, perturbing the entire pregnancy. The placenta is responsible not only for hormonally and physically …

Circulating Tumor Dna Monitoring And Blood Tumor Mutational Burden In Patients With Metastatic Solid Tumors Treated With Atezolizumab, Charles Swanton, Russell W Madison, Candice Francheska B Tambaoan, Funda Meric-Bernstam, Christopher J Sweeney, Howard A Burris, Hanna Tukachinsky, Jason Hughes, Julia Malato, Bongin Yoo, Tania Szado, Cheryl Schwab, Lincoln W Pasquina, Amaya Gasco, Katja Schulze, Claire F Friedman

Faculty, Staff and Student Publications

Immune checkpoint inhibitors are important for treatment across tumor types but are not universally effective in controlling disease. Early understanding of tumor response, or lack thereof, can inform treatment decisions. This study evaluates changes in circulating tumor DNA (ctDNA) and blood tumor mutational burden (bTMB) for associations with response to programmed cell death 1 ligand 1 (PD-L1) blockade. We sequenced cell-free DNA collected at the start of therapy, on treatment, and at the end of therapy for 153 patients treated with atezolizumab as part of the pan-tumor MyPathway study (NCT02091141). ctDNA tumor fraction (TF) and bTMB were assessed …

Histodx: Revolutionizing Breast Cancer Diagnosis Through Advanced Imaging Techniques, Wishal Arshad, Tehreem Masood, H. M. Shahzad, Hassan A. Ahmed, Syed Hamza Ahmed, Hafiz Muhammad Tayyab Khushi

Business Faculty Publications

Breast cancer is the second leading cause of mortality among women worldwide, highlighting the need for efficient histopathology-based screening methods for early diagnosis. This study introduces HistoDX, a deep learning framework to classify Invasive Ductal Carcinoma (IDC) using 277,524 histopathology image patches (50x50 pixels) from Paul Mooney’s IDC dataset on Kaggle, comprising No Cancer and IDC(+) classes. HistoDX employs a preprocessing pipeline with normalization, data augmentation, and class balancing via oversampling and weighted loss to address the class imbalance. A customized convolutional neural network, built on EfficientNetV2-B3 with additional layers, achieves 97% accuracy and a 0.91 ROC-AUC score on the …

Histodx: Revolutionizing Breast Cancer Diagnosis Through Advanced Imaging Techniques, Wishal Arshad, Thhreem Masrood, H. M. Shahzhad, Hassan A. Ahmed, Syed Hamza Ahmed, Hafiz Muhammad Tayyab Khushi

Business Faculty Publications

Breast cancer is the second leading cause of mortality among women worldwide, highlighting the need for efficient histopathology-based screening methods for early diagnosis. This study introduces HistoDX, a deep learning framework to classify Invasive Ductal Carcinoma (IDC) using 277,524 histopathology image patches ( 50×50 pixels) from Paul Mooney’s IDC dataset on Kaggle, comprising No Cancer and IDC(+) classes. HistoDX employs a preprocessing pipeline with normalization, data augmentation, and class balancing via oversampling and weighted loss to address the class imbalance. A customized convolutional neural network, built on EfficientNetV2-B3 with additional layers, achieves 97% accuracy and a 0.91 ROC-AUC score on …