Digital Commons Network^™

Strategies For Thoughtful Dissemination Of Climate Change Knowledge: A Blueprint For Scientists In The Heart Of The Empire, Christopher Cronk

Nepal: Geoscience in the Himalaya

This interdisciplinary research investigates how climate change education, Indigenous knowledge systems, journalism, and anthropology intersect in shaping environmental awareness and action, focusing primarily on Nepal and drawing parallels with Indigenous Peoples of Turtle Island (North America). Stationed in Kathmandu, I conducted interviews with climate educators, journalists, anthropologists, and activists to explore how scientific and local knowledge are communicated and acted upon. Findings highlight the strong awareness of climate change in Nepal, the systemic barriers to effective mitigation and adaptation, and the potential of community-led initiatives like the Community Forest Program. Anthropological insights proved crucial in linking human experience to environmental …

A Preliminary Classification And Quantification Of The Microplastics Within Remote Glacial Runoff In The Upper Manang Region Of Nepal, Caden Lipsky

Nepal: Geoscience in the Himalaya

Microplastics, defined as particles of plastic waste less than 5mm (US EPA), are becoming steadily more common throughout remote ecosystems and are damaging to human and environmental health. The level of microplastics found in water sources within remote regions has become increasingly concerning following growing influxes of tourists and residents each year. These particulates found in freshwater have historically only been found downstream of populated areas; however, more recent cases have demonstrated their appearance at higher elevations and lower population water sources. This study aims to develop a preliminary understanding of the amount and type of contamination that has occurred …

Flood Risk Reduction: An Analysis Of Policy, Policy Implementation, And The Role Of Non-Governmental Organisations, Elsa Cutler

Nepal: Geoscience in the Himalaya

As global temperatures rise, flood frequency and severity increase due to unpredictable rainfall, consequently escalating flood risk for Nepal's population. Therefore, implementing mitigation strategies and disaster risk reduction operations has become of utmost importance to effectively protect the people of Nepal. In 2024, countless lives were lost and a great deal of infrastructure was destroyed in Kathmandu due to the floods that swept through the city. The scale of damage the flood caused could have been minimized if the risk management policies in place were enforced properly. This investigation uses interviews, news reports, policies, policy analyses, and the case study …

Occupancy Sampling To Examine Spatial Distribution Of Oklahoma Salamanders (Eurycea Tynerensis) Among Headwater Streams In The Ozark Highlands, Sophia Anreder

Biological Sciences Undergraduate Honors Theses

Water conditions are changing globally due to climate change (Gleick, 1989). Headwater streams specifically are vulnerable to changes in hydrology, water quality, and physical characteristics from anthropogenic practices due to their small watersheds with shallow soils, yet they are often not a priority in conservation (Campbell et al., 2011; Abell et al., 2017). Within streams, plethodontid (i.e., lungless) salamanders, which are also sensitive to environmental changes, may be restricted in their distribution due to undefined stream characteristics and predation by fish (Welsh and Droege, 2002; Kuhajda et al., 2015). To better understand the pressures that influence stream salamander occupancy, I …

Primary Investigation Of Rice-Fish Co-Culture: Investigating The Feasibility Of Raising Fish In Flooded Rice Paddies In The Southern Usa, Yulin Jia, Aaron K. Jackson, Bartholomew Green, S. Adam Fuller, Heather Box, Laduska Sells, Candis Ray, Paxton Harper, Brennan Smith

United States Department of Agriculture-Agricultural Research Service / University of Nebraska-Lincoln: Faculty Publications

With limited land and water resources available it has become critical to maximize output for agricultural products while maintaining sustainable farming practices. Ricefish co-culture can be used to maximize limited land and water resources for production of rice and fish concurrently and reduce the need of chemical inputs. While rice-fish co-culture has been practiced in Asia for centuries, very few studies have examined the feasibility and economic impact of rice fish co-culture in the U.S.A. Two studies were conducted in Stuttgart, Arkansas, U.S.A. from 2023-2024 to investigate the suitability of raising Koi carp in flooded rice paddies with a sushi …

Editorial: The Role Of Diagnostics In Eliminating Schistosomiasis As A Public Health Problem: Trend And Need, James Mwansa, Moses J. Chimbari, Nilanjan Lodh

Clinical Lab Sciences Faculty Research and Publications

No abstract provided.

An Agricultural Needs Assessment In The Tri-County Area Of Utah, Cheyenne Reid, Lendel K. Narine, Brooke Holgate

Outcomes and Impact Quarterly

An agricultural needs assessment was conducted in the Tri-County area, i.e., Uintah, Daggett, and Duchesne counties, to inform extension programming. Results showed that profitability, business development, and land use were high-priority needs. Gaps in producers’ access to information were found, highlighting the need for targeted education programs to address agricultural challenges.

Artificial Intelligence In Healthcare And Science, Sally Brown, Catherine Gouge, Anurag Srivastava

Artificial Intelligence Exhibit

This section explores AI's impact on science and healthcare, including medical diagnostics and treatments, and scientific research.

To Pause With A Cliffhanger Or A Temporary Closure? The Differential Impact Of Serial Versus Episodic Narratives On Children's Physical Activity Behaviors, Amy Shirong Lu, Melanie C Green, Caio Victor Sousa, Jungyun Hwang, I-Min Lee, Debbe Thompson, Tom Baranowski

Children’s Nutrition Research Center Staff Publications

Research has supported the effectiveness of narratives for promoting health behavior, but different narrative presentation formats (serial vs. episodic) have seldom been compared. Suspense theories suggest that serial narratives, which do not provide a full resolution at the end of an episode, may create higher motivation for continued engagement with a story. Forty-four 8 to 12-year-old children were randomly assigned to watch an animation series designed for an existing active video game in which the plot was delivered either continuously across multiple episodes (serial) or in multiple yet relatively independent self-contained episodes (episodic). Controlling for social desirability, children who watched …

A Brief Guide To Statistical Analysis Of Grouped Data In Preclinical Research, Colby J Vorland, Lilian Golzarri-Arroyo, David B Allison

Children’s Nutrition Research Center Staff Publications

Clustering and nesting (C&N) arise in many preclinical studies such as when animals are group-housed, share litters, or in cell culture. Ignoring C&N undermines the validity of analyses. We explain how C&N arise and valid designs and analyses.

Two Spectroscopy Devices Can Approximate Fruit And Vegetable Intake In A Racially And Ethnically Diverse Sample, Stephanie B Jilcott Pitts, Qiang Wu, Melissa N Laska, Nancy E Moran

Children’s Nutrition Research Center Staff Publications

Background: Assessing fruit and vegetable intake is important to determine the effectiveness of nutrition intervention studies. Few objective measures of fruit and vegetable intake have been directly compared within the same study participants.

Objectives: This study aims to compare the relative validity of 2 different skin spectrophotometry devices to serve as biomarkers of plasma carotenoid concentrations, self-reported fruit and vegetable intake (FVI), and carotenoid intake, to examine if both devices can be used to approximate FVI.

Methods: Human skin carotenoid scores (SCS, Veggie Meter-assessed) and color space measurement data from 2 prior studies were used. Participants' skin color space parameters …

Exploring The Composition Of Forest Collaboratives In Northeastern Oregon, Lee K. Cervany, Rebecca J. Mclain, Kristen Wright

National Policy Consensus Center Publications

Community-based collaboration has been touted as an effective model for forest governance because it promotes democratized decision-making and stakeholder engagement to address landscape-scale problems. Forest collaboratives are assumed to be heterogeneous, consisting of stakeholders with a diverse range of interests. Few studies have systematically explored variables associated with collaborative composition. We identify six elements of collaborative composition for investigation: size, stakeholder diversity, balance, locality–diversity, core attendance, and cross-participation. This exploratory study examines five forest collaborative groups in eastern Oregon (USA). We analyzed meeting minutes over an 18-month period to track attendance and evaluate who shows up and at what frequency. …

Overcoming Maternal Antibody Interference In Swine Influenza: Advancing Dna Vaccine Strateies For Enhanced Immune Protection In Piglets, Danh Cong Lai

School of Veterinary and Biomedical Sciences: Dissertations, Theses, and Student Research

Maternally derived antibodies (MDAs) play a vital role in protecting neonates from infectious diseases, but their presence at the time of vaccination can interfere with vaccine-induced immune responses, thereby reducing vaccine effectiveness. MDA interference has been documented in pigs vaccinated with whole inactivated virus (WIV) vaccines against swine influenza A virus (IAV). In this thesis, we evaluated the efficacy of a lipid nanoparticle encapsulated DNA (LNP-DNA) vaccine against swine IAV in the presence and absence of MDAs, comparing it to a WIV vaccine. In MDA-negative piglets, both the LNP-DNA and WIV vaccines induced strong immune responses and effectively prevented the …

Investigating The Role Of Msbdnf – Trkb Signaling In The Maintenance Of Mitochondrial Populations Through The Bnip3 Mitophagy Pathway, Jack A. Horton

All NMU Master's Theses

Maintenance of mitochondrial transport and clearance at the pre- and post-synaptic terminal is an essential function of neuromuscular junctions to meet their high energy demands. Damaged or dysfunctional mitochondria can put stress on these synaptic junctions, ultimately leading to the degradation of the synapse and subsequent cell death. Dysfunctional mitochondria are also often present in neuromuscular diseases such as ALS. One possible mechanism by which neurons may eliminate dysfunctional mitochondria is through the muscle-synthesized BDNF (msBDNF) /TrkB-mediated Bcl-2 nineteen-kD interacting protein (BNIP3) mitophagy pathway, although the relationship is not well-defined. BNIP3 localizes to the mitochondria and triggers a loss of …

Elucidating The Role Of Mir-10a/B In The Wound Healing Process In Larval Zebrafish, Jacquelyn E. Jacobs

All NMU Master's Theses

This study explores the regulatory role of microRNA-10 (miR-10) in larval zebrafish caudal fin regeneration, a model with broad implications for the future of regenerative medicine. Building on prior research from the lab, which indicated that miR-10 knockdown impairs regeneration, we verified this finding through rescue experiments, assessed its influence on healing projections, and examined its role in the innate immune response during the wound healing process. To address these questions, we employed a multi-faceted approach, including timed matings, microinjections, immunohistochemistry, fixed sample microscopy, and live imaging. Our results show that the experimental introduction of exogenous miR-10 can rescue the …

1080 Baiting Information For Pet Owners, Department Of Primary Industries And Regional Development, Western Australia

Biosecurity factsheets

A must for pest control, but a risk to domestic pets.

1080 is the brand name given to the chemical compound sodium monofluoroacetate. It is the synthetically produced sodium salt of fluoroacetate and produced as a white powder which is odorless and tasteless to humans. 1080 has been developed for incorporating into various bait formulations for the control of vertebrate pests including wild dogs, foxes, feral cats, and feral pigs.

Foxo Factors’ Ability In Binding To And Inducing Tcf7 In Glioblastoma Cells, Stephanie Oyervides

Theses and Dissertations

Glioblastoma Multiforme (GBM) is an aggressive astrocytoma tumor type with a poor prognosis and limited immunotherapeutic options for those inflicted. Stem gene expression of this cancer indicates a direct relationship with the transcription factors, Forkhead box subfamily O (FOXO-1, -3 and - 4). These transcription factors are evolutionarily conserved, partially redundant. They are involved in diverse and fundamental biological processes such as cell survival, stem cell homeostasis, cell fate determination, cell cycle maintenance, metabolism, and apoptosis. Increasing evidence suggests interconnectivity between the WNT Pathway and FOXO transcription factors; however, the mechanism and full extent to which these interactions play a …

Oxytocin As A Possible Vegf Inhibitor For Treatment Of Diabetic Retinopathy, Daira Yepez

Theses and Dissertations

Diabetic retinopathy (DR) is a major complication of diabetes and a leading cause of vision loss largely driven by the overexpression of vascular endothelial growth factor (VEGF), which promotes neovascularization and vascular permeability in the retina. Current treatments, primarily anti-VEGF injections, inhibit the effects of VEGF once it has been secreted but can be ineffective in a certain subset of patients. Recent studies suggest that oxytocin (OXT), a neuropeptide mainly known for its roles in reproduction and social bonding, may downregulate VEGF expression. This study aimed to investigate whether OXT influences VEGF secretion in the human retinal pigment epithelial (RPE) …

Nantucket Eelgrass Management Plan, Kimberly Starbuck, Kristin Uiterwyk, Shannon Hogan

Urban Harbors Institute Publications

Eelgrass is a critical component of our coastal ecosystem, supporting marine biodiversity, improving water quality, and helping to stabilize the shoreline. This planning effort aims to support the long-term health and sustainability of eelgrass habitats in our local waters.

Eelgrass (Zostera marina L.) is a subtidal seagrass found on both the east and west coasts of North America. Over the last 40 years, eelgrass has declined worldwide as a result of increased turbidity, algal blooms, physical disturbances, disease, and a host of other stressors. Specifically, in Massachusetts, the eelgrass population has declined approximately 50% in the last 30 …

L-Quebrachitol Modulates The Anti-Convulsant Effects Of Carbamazepine Possibly Through Voltage-Gated Sodium Channel Blocking Mechanism In Chicks: In Vivo And In Silico Studies, Asifa Asrafi, Mohammad Aslam, Ali G. Alkhathami, Md. Sakib Hossain, Imam Hossen Rakib, Md. Sakib Al Hasan, Feroz Khan Nun, Md. Faisal Amin, Muhammad Torequl Islam

School of Integrative Biological & Chemical Sciences Faculty Publications

Introduction: L-Quebrachitol (LQB), a naturally occurring bioactive compound, exhibits anti-inflammatory, anti-oxidant, anti-cancer, and anti-diabetic properties. However, its therapeutic potential in convulsant management remains largely unexplored. The objective of this study was to investigate the anticonvulsant effects of LQB in an In Vivo model and to examine its molecular interactions via In Silico docking simulations.

Methods: In the In Vivo study, pentylenetetrazol (PTZ) was administered intraperitoneally (i.p.) at 80 mg/kg to induce convulsions, and the test animals were treated orally with three doses of LQB (1, 5, and 10 mg/kg), with carbamazepine (CBZ) at 80 mg/kg as a standard drug.

Results: …

Circannual And Kinship Cues Shape Reproduction And Epigenetic Aging In Peromyscus, Kim Tuyen Huynh Dam

Theses and Dissertations

Evolutionary success is defined by the ability of a species to adapt and survive across many generations. This success is not determined by any single attribute but rather includes the entrenched, complex system that could be associated with biological rhythms, reproductive strategies, and regulations of epigenetic and genetic components. By using closed Peromyscus colonies as a model and by coupling mathematical modeling, analyses of breeding records, epigenetic studies, and in vitro and in vivo experiments, this dissertation aims to discover how Peromyscus adjusts to the internal and external pressures to ensure their survival and preserve evolutionary fitness in controlled environments. …

Exploring The Ancestry And Mutational Signatures Of Free-Breeding Dogs From Chernobyl And The Galápagos Islands, Gabriella Jean Spatola

Theses and Dissertations

Two free-breeding dog populations, one in Chernobyl, Ukraine, and the other on the Galápagos Islands, Ecuador, exist on opposite sides of the globe, yet both hold unique scientific potential to further our understanding of free-breeding dog population dynamics and evolutionary processes related to their environments. In the following studies, blood samples from more than 400 individual Chernobyl dogs were collected and their genomes were analyzed alongside over 1500 purebred and 200 global free-breeding dogs, describing genetic relationships and the extent of admixture with purebred migrants. Importantly, the sampled Chernobyl dogs had long-term exposures to ionizing radiation because of the 1986 …

Investigating The Immunomodulatory Effects Of Cdk8/19 Inhibitor Senexin631 In A Her2-Positive Breast Cancer Model, Stephen O'Rourke

Theses and Dissertations

HER2-positive (HER2⁺) breast cancer is aggressive and often develops resistance to anti-HER2 therapies. CDK8 and CDK19, transcription-associated cyclin-dependent kinases (tCDKs) in the Mediator complex, are dysregulated in HER2⁺ breast cancer, correlate with poor survival, and support transcriptional escape driving therapeutic resistance. Previous studies Previous studies in immune-deficient models demonstrated that CDK8/19 inhibition (CDK8/19i) reduces pro-tumor macrophages (M2Φs), but its role in immune-competent tumors and innate immune–mediated tumor control remains unclear. Since HER2⁺ tumors are often immunogenic and anti-HER2 therapies rely on innate immune activation, reprogramming immunosuppressive M2Φ toward an M1Φ-like phenotype could enhance antitumor immunity. We hypothesized that CDK8/19i modulates …

Novel Approaches To Combat Neuro-Degradation: Investigations Of Two Supplemental Strategies Aimed At Improving Warfighter Performance, Blaine Lints

Theses and Dissertations

This dissertation examines the efficacy of two distinct nutritional supplementation strategies for improving physical and/or cognitive performance under stress. The first study investigated the effects of 150 mg caffeine plus 150 mg theacrine ingestion in tactically trained individuals. Results indicated that the combination of caffeine and theacrine was associated with significant improvements in reaction time, accuracy, and measures of ocular control following high-intensity interval (HII) exercise. The HII exercise protocol consisted of ten repetitions of 60s high-intensity intervals (≥90% maximal oxygen uptake [VO_2max]) followed by 120s low-intensity intervals (~40% VO_2max) on a treadmill. These benefits were …

Investigating Mechanisms And Day-Level Factors That Influence Children’S 24-Hour Movement Behaviors, Hannah Parker

Theses and Dissertations

Twenty-four hour movement behaviors (i.e., physical activity (PA), screen time (ST), and sleep) are associated with health outcomes, chronic disease (obesity, type 2 diabetes), and mortality. Most literature evaluating children’s 24-hour movement behaviors has focused on static person-level demographic information such as age or biological sex. Relatively less work has examined the variable factors that change day to day, such as environment or context. The Structured Days Hypothesis (SDH) suggests that when children are in structured environments, they have healthier movement behaviors compared to less structured environments where children have more discretionary time to engage in obesogenic behaviors. Besides school/childcare, …

Modeling The Interaction Between Pain And Movement: Insights From Brain Activation Patterns And Context-Dependent Emotion In Chronic Low Back Pain, Pradeep Kumar Sahu

Theses and Dissertations

In persons with chronic pain, fear or anxiety related to movement is a well-established model under the biopsychosocial framework that explains in part, the chronicity of symptoms commonly reported by individuals with chronic low back pain (cLBP). This dissertation aimed to further understand the link between the context-dependent emotion network in the brain and movement in two separate studies using brain functional MRI and autonomic nervous system indices. Aim 1sought to investigate the brain functional connectivity linking brain regions involved in context-dependent emotion and movement while cLBP participants moved their back inside the scanner by performing a modified trunk bridging …

Teratogenic Effects Of Serotonin Receptor 2b Disruption On The Migration And Cardiac Derivatives Of The Cardiac Neural Crest, Brian K. Wells, Gwyneth K. Garramone, Amira Mahomed, Max Ezin

Biology Faculty Works

Background: Cardiac neural crest cells (cNCCs) are critical for heart development, and their disruption can result in congenital heart defects. Serotonin (5-HT) signaling, specifically via 5-HT2B and 5-HT2C receptors, regulates diverse physiological processes, including neural crest migration. This study investigates how modulation of 5-HT2B and 5-HT2C receptor activity impacts cNCC migration and the development of their derivatives, with relevance to serotonergic drug safety during pregnancy.

Methods

Chicken embryos at HH8 were treated with 50 μL of 20 μM 1-Methylpsilocin (1-MP), an inverse agonist of 5-HT2B and agonist of 5-HT2C, and collected at HH14 to assess cNCC migration. Embryos were pre-treated …

Reaction Control Mechanism In Deoxyuridine 5'-Triphosphate Nucleotidohydrolase, Aaron Delay

School of Biological Sciences: Dissertations, Theses, and Student Research

Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) is an enzyme involved in the pyrimidine biosynthesis pathway, a key component of cellular DNA metabolism. It regulates intracellular uracil carrying triphosphate levels by hydrolyzing dUTP, thereby providing a substrate for thymidylate synthase (TS). The effective inhibition of dUTPase is expected to enhance TS-targeted chemotherapy by promoting thymine-less apoptosis.

Although the reaction mechanism of dUTPase has been studied, the human nuclear homotrimeric form remains complex, as all three subunits cooperatively form a single active site. As a result, the detailed molecular dynamics of its catalysis are still not fully understood. In this study, I investigated the …

Automated Mycoplasma Genitalium Molecular Macrolide Resistance Detection And Nucleic Acid Target Semi-Quantitation: Patient Demographic Considerations, Josephine Moore, Trinity Krueger, Amanda Zapp, Stephen C. Lavey, Kimber L. Munson, Irene A. Stafford, Michael E. Newcomb, Brian Mustanski, Erik Munson

Clinical Lab Sciences Faculty Research and Publications

Recent work has optimized parameters of a real-time reverse transcriptase PCR-based laboratory-developed test on the Panther Fusion system which detects Mycoplasma genitalium-specific macrolide resistance-associated mutations LDT (MRM-LDT) from primary swab and urine specimens. In this study, MRM-LDT was applied to a large multi-demographic study set to further characterize M. genitalium resistance in the United States. A total of 2,145 primary clinical specimens testing positive for M. genitalium 16S rRNA by transcription-mediated amplification (TMA) were initially titered by the same assay using serial 10-fold dilutions to determine relative target nucleic acid burden. Specimens were then processed for MRM-LDT. Findings were stratified …

Pollination And Essential Oil Production Of Lavandula Angustifolia Mill. (Lamiaceae), Riley B. Jackson, Tyler M. Wilson, Joseph S. Wilson, Zabrina Ruggles, Lindsey Topham Wilson, Chris Packer, Jacob G. Young, Christopher R. Bowerbank, Richard E. Carlson

Biology Faculty Publications

Lavandula angustifolia Mill., lavender, is an aromatic plant in the Lamiaceae family. Lavender, which is native to the Mediterranean region but cultivated throughout the world, is an important economic plant. Several studies have investigated two aspects of this aromatic plant: (1) which pollinators, particularly bees, pollinate lavender, and (2) the composition of lavender essential oil. However, little research has been conducted to investigate how pollination affects either the yield or phytochemistry of lavender. The current study, which was conducted in North America, investigates which bee species visit lavender and how pollination affects plant chemistry, specifically the essential oil produced by …