Digital Commons Network^™

Suturing Education For Athletic Trainers: An Evidence-To-Practice Review, Morgan K. Webb, Brett T. Heim, Allyson E. Ritchey, Kenya Moore, Zachary K. Winkelmann

Clinical Practice in Athletic Training

Teaching suturing skills to medical students is a critical component of their education. Implementing suturing into a comprehensive framework is developed from how professors teach the skill. Suturing is a required skill by the General Medical Council that all medical students must have, and how it is being introduced to new students is changing. This review aimed to summarize different educational interventions and determine the most efficient and cost-effective way to teach future suturing skills. The original systematic review included 25 articles in the final data synthesis. Fourteen studies were randomized control trials, six were quasi-experimental, and five were observational. …

Evaluating The Performance And Feasibility Of A Device-Agnostic Approach To Compare Raw Accelerometry And Hr Data From Consumer Wearables To Research Grade Devices In Young Adults, Candy Bryan Mrudula Yalla

Theses and Dissertations

INTRODUCTION: Wearable technologies are increasingly used to monitor physical activity and heart rate in both research and everyday settings. This study aimed to compare accelerometery and heart rate (HR) data from two consumer wearables Apple Watch Series 7 and Google Pixel Watch Series 2, with research-grade devices: the ActiGraph GT9X Link and ActiHeart 5.

METHODS: Twenty-four young adults aged 18–24 years (mean age = 22.4; 54.2% female) participated in a 90-minute activity protocol while wearing the devices. The protocol included structured tasks ranging from rest to vigorous intensity. Consumer wearables and ActiGraph were worn on the non-dominant wrist, and the …

The Green Plate Effect: Systematic Review And Meta-Analyses Of Vegan Diets And Metabolic Health In Adults- Findings From Randomized Controlled Trials, Wai-Kit Tom, Aaron Deming Looi, Vijayakumar Nithusharini, Kavitha Lakshmipathy, Uma Devi Palanisamy, Usha Sundralingam

Food Science Faculty Publications and Presentations

Background: The increasing global interest in consuming plant-based diets, especially the vegan diet, is fuelled by ethical, health, and environmental concerns. A balanced and diverse vegan diet has the potential to play a significant role in achieving and sustaining optimal health, particularly in diet-based interventions for metabolic syndrome. Scope and approach: This systematic review evaluated randomised controlled trials, to elucidate the effects of a strict vegan diet on individual components of metabolic syndrome in the human population. A comprehensive literature search was conducted across four databases (Cochrane Central Register of Controlled Trials; Embase via Ovid; Ovid Medline; Scopus). The search …

Sulforaphane And Non-Clustered Tumor/Non-Tumor Suppressor Micrornas Regulate Akt And Its Downstream Genes In Mda-Mb-231 Cancer Cells, Omobolanle David Garuba

Dissertations (2016-Present)

Cancer is a complex pathological condition characterized mainly by uncontrolled rapid cell divisions caused by several factors, which include genetics and environmental factors. Of all cancer types, breast cancer (BC) remains the second most diagnosed among women worldwide; thus, BC burden has become a global health issue. Of all known breast cancer subtypes, triple-negative breast cancer (TNBC) is the only primary subtype without effective therapy as a result of their lack of the essential estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2) common to other BCs and are the usual therapeutic targets for treatment. …

Detection Of Microplastics In Household Dust From Suburban Texas And Toxicological Assessment Of Polystyrene Microparticles In Lung Epithelial Cells: Nf-Kb Pathway Activation And Inflammatory Responses, Nirupama Surubhotla

Dissertations (2016-Present)

Microplastics are emerging contaminants that have raised global concern due to their persistence, ubiquity, and potential impacts on human health. Indoor environments are increasingly recognized as significant sources of microplastic exposure through household dust inhalation. This study aimed to detect the presence of microplastics in household dust from suburban regions of Texas, USA, and to investigate the cytotoxic and inflammatory effects of polystyrene microparticles in a lung epithelial cell model (A549). Household dust samples were collected and analyzed using Raman spectroscopy, confirming the presence of a mixture of microplastics. To assess biological responses, A549 cells were exposed to defined sizes …

Curcumin And Compound-20 (A Synthetic Curcumin) Ameliorates Effects Of Acrolein In Rat Kidney By Improving Renal Autophagy, Sandra Isioma Erue

Dissertations (2016-Present)

Study aim is to determine the role of p38-MAPK/Nrf2 and NF-κB signaling in acrolein-induced kidney injury. Evaluate autophagy modulation and whether curcumin and Compound 20 mitigate acrolein-induced kidney injury by modulating p38-MAPK/Nrf2 and NF-κB pathways. Male Sprague–Dawley rats were randomly divided into groups (n = 5) for control and treatment. All rats were fasted for 4–5 hours daily throughout the 10-day study period. Male Sprague–Dawley rats were administered peanut butter, curcumin, or Compound-20 mixed with peanut butter via voluntary oral consumption, followed by intraperitoneal (IP) administration of acrolein. The animals were randomly divided into groups (n = 5) for control …

Herthena-Pantumor01: A Phase Ii Study Of Patritumab Deruxtecan (Her3-Dxd) In Previously Treated Advanced Solid Tumors, Thomas Powles, Aarti Bhatia, Barbara Burtness, Takahiro Kogawa, Tomohiro Nishina, Izuma Nakayama, Christos Fountzilas, Dani R Castillo, Meredith Mckean, Funda Meric-Bernstam, Nicoletta Colombo, James W Smithy, Jérome Fayette, Sunandana Chandra, David W Sternberg, Fan Jin, Kendall Sullivan, Sue Yueh, Graham Clinthorne, Ariel E Aguilo, Ragini Kudchadkar, Hidetoshi Hayashi

Faculty, Staff and Student Publications

Human epidermal growth factor receptor 3 (HER3) is a receptor tyrosine kinase that is expressed in numerous solid tumors. Higher levels of HER3 expression in multiple tumor types are associated with adverse clinical outcomes, such as reduced survival. However, there is currently no HER3-directed antibody-drug conjugate approved for the treatment of any cancer. Improved treatment options are needed, in particular for patients who progress on standard therapies. HER3-DXd is an investigational HER3-directed antibody-drug conjugate composed of an anti-HER3 monoclonal antibody linked to a topoisomerase I inhibitor payload via a stable tetrapeptide-based cleavable linker. In previous clinical trials, HER3-DXd demonstrated a …

Lesion Absorbed Dose-Response Relationship In Patients With Metastatic Castration-Resistant Prostate Cancer Undergoing [177lu]Lu-Psma-617 Radiopharmaceutical Therapy, Milan Grkovski, Simone S Krebs, Joseph A O'Donoghue, Jonathan Kuten, Audrey Mauguen, Parnian Shobeiri, Daniel Lafontaine, Maria Thor, Finn Augensen, Josef J Fox, Neeta Pandit-Taskar, Mark P Dunphy, Lisa Bodei, John L Humm, Heiko Schöder

Faculty, Staff and Student Publications

The relationship between lesion absorbed dose (AD) and response in patients with metastatic castration-resistant prostate cancer undergoing [177Lu]Lu-PSMA-617 radiopharmaceutical therapy (RPT) remains poorly understood. The objective of this work was to investigate the AD-response relationship at both the patient and lesion levels.

Methods: Sixty-five patients underwent serial SPECT/CT imaging after receiving 7.31 ± 0.27 GBq of [177Lu]Lu-PSMA-617. Single-time-point (STP) (Hänscheid approximation at 72 h) and multiple-time-point voxelwise dosimetry were performed. Patient response was evaluated by changes in serum prostate-specific antigen level before and after cycle 1 of RPT. The response of individual lesions was evaluated by the change in the …

From Nociception In Aneural Animals To Human Suffering: Toward A Comparative Biology Of Pain, Edgar T Walters

Faculty, Staff and Student Publications

Pain is a core feature of human life, but systematic comparisons of this biological trait across taxa have been rare. A broadly accepted definition based on human experience emphasizes dual features of pain: a sensory (discriminative) component for sensing and monitoring tissue injury, and an affective (emotional) component to motivate avoidance of tissue distress. Conscious pain is coupled to unconscious nociception (detection of incipient or existing injury). This Review considers nociception and pain across phyla within a comparative framework, addressing basic questions about evolutionary origins, mechanisms and functions of pain. The occurrence of adaptive cellular responses to injury in virtually …

Epigenetic Age Acceleration Mediates Treatment Effects On Cardiometabolic And Cardiovascular Risk In Childhood Cancer Survivors, Xiaoxi Meng, Tiffany Eulalio, Yoonji Kim, John Easton, Heather L Mulder, Emily Walker, Geoffrey Neale, Nan Song, Kyla Shelton, Rebecca M Howell, Mengqi Xing, Sedigheh Mirzaei, Deo Kumar Srivastava, Bonnie Ky, Stephanie B Dixon, Melissa M Hudson, Kirsten K Ness, Gregory T Armstrong, Zhaoming Wang

Faculty, Staff and Student Publications

BACKGROUND: Childhood cancer survivors are at increased risk for epigenetic age acceleration (EAA) and subsequent morbidities, including cardiometabolic risk factors (CMRFs) and cardiovascular diseases, because of prior genotoxic treatments.

OBJECTIVES: The aim of this study was to evaluate the mediating role of EAA in the relationship between cancer treatment exposures and risk for CMRFs and cardiovascular diseases.

METHODS: This study included 2,939 5-year survivors from SJLIFE (St. Jude Lifetime Cohort) who underwent DNA methylation profiling using peripheral blood mononuclear cells. EAA was calculated using 3 established epigenetic clocks: DunedinPACE, PCPhenoAge, and GrimAge2. Treatment data, including body region-specific radiotherapy (RT) and …

A Phase 2 Study Of Cpx-351 In Combination With Venetoclax In Patients With Newly Diagnosed High-Risk Acute Myeloid Leukemia, Wei-Ying Jen, Jennifer Croden, Emmanuel Almanza-Huante, Courtney Dinardo, Kelly Chien, Danielle Hammond, Wei Qiao, Yesid Alvarado, Lucia Masarova, Andres E Quesada, Sherry Pierce, Alex Bataller, Guillermo Garcia-Manero, Amin Alousi, Nicholas Short, Naval Daver, Farhad Ravandi, Hagop Kantarjian, Tapan M Kadia

Faculty, Staff and Student Publications

Venetoclax has been combined with intensive chemotherapy regimens in the treatment of acute myeloid leukemia (AML). We aimed to investigate the safety and efficacy of venetoclax combined with full‐dose CPX‐351 (CPX + VEN) in newly diagnosed (ND) AML. Seventeen patients with a median age of 59 years (range, 43–69) were treated; 71% had secondary AML, 47% had prior hypomethylating agent (HMA) exposure, 59% had myelodysplastic syndrome (MDS)‐related (MR) mutations, 47% had complex karyotype, and 29% were TP53 mutated. The overall response rate (ORR) was 82% (95% CI, 57–96) with a composite complete remission rate (CRc) of 71% (95% CI, 50–93). …

Hooks For Four-Dimensional Ecology Education (4dee) Teaching With Differing Audiences Of Nonmajors, Sara E. Scanga, Vikki L. Rodgers, Loren B. Byrne, Justin R. St. Juliana, Jon M. Honea, Erica S. Tietjen, George Middendorf

Arts & Sciences Faculty Publications

Nonmajors (i.e., undergraduate students not majoring in the natural sciences) constitute a majority of United States college graduates and are a large potential audience for courses with ecology content. However, nonmajors may be unmotivated to learn about ecology because they perceive it to be uninteresting and irrelevant to their everyday lives or career goals. Although the Four-Dimensional Ecology Education (4DEE) framework can be adapted for nonmajors courses as a starting point to improve student engagement, we suggest that nonmajors ecology instructors also use ecology hooks as effective gateways to 4DEE that will motivate and deepen student learning. Selecting and developing …

Multi-Institution Analysis Of Tarlatamab For The Treatment Of Egfr-Mutant Transformed Small Cell Lung Cancer, Alissa J Cooper, Benjamin Herzberg, Mitchell Parma, Kaiwen Wang, Laura Alder, Urs M Weber, Tejas Patil, Utsav Joshi, Sonam Puri, Anjali Saqi, Phoebe Clark, Carl M Gay, Tina Cascone, Eric K Singhi, George Blumenschein, Ferdinandos Skoulidis, Janet Tu, Thomas E Stinchcombe, Charles M Rudin, Catherine A Shu, Lauren A Byers, Helena Yu, Bingnan Zhang

Faculty, Staff and Student Publications

No abstract provided.

Pka-Driven Spp1 Activation As A Novel Mechanism Connecting The Bone Microenvironment To Prostate Cancer Progression, Pablo Sanchis, Agustina Sabater, Julia Lechuga, Jimena Rada, Rocio Seniuk, Gaston Pascual, Mora Gatti, Juan Bizzotto, Peter D A Shepherd, Jun Yang, Javier Cotignola, Elba Vazquez, Joaquin Mateo, Pia Valacco, Estefania Labanca, Christopher Logothetis, Geraldine Gueron, Nicolas Anselmino

Faculty, Staff and Student Publications

Prostate cancer (PCa) bone metastasis (BM) poses a significant clinical challenge due to the heterogeneity of treatment responses and patient outcomes. In this study, we examined the role of Protein Kinase A (PKA) signaling in modulating the expression of osteopontin (SPP1/OPN), a protein associated with poor prognosis, within a subset of PCa BM patients. By integrating multi-omics results we identified a novel mechanism in which bone-derived type-I collagen (Col1a1) and fibronectin (Fn1) stimulate SPP1 expression in PCa cells through the activation of PKA signaling. This bone-induced regulation of SPP1 was confirmed both in vitro, using PCa-bone co-culture systems (PC3 or …

Alterations In Region-Specific Gray Matter Volume Underlying Callous Unemotional Traits In Adolescents, Johannah Bashford-Largo, Ru Zhang, R James R Blair, Karina S Blair, Jaimie Elowsky, Matthew Dobbertin, Ahria J Dominguez, Melissa Hatch, Tyler Patrick, Sahil Bajaj

Faculty, Staff and Student Publications

Background: Callous-unemotional (CU) traits during adolescence, for example, shallow affect or lack of remorse, have been shown to be a risk marker for antisocial behavior. Only a few studies have investigated structural brain alterations underlying CU traits, and findings are inconclusive. The study examines CU symptomatology and gray matter volume (GMV) associations.

Methods: Structural brain MRI data were collected from a sample of 578 adolescents (60% male) with a mean age of 14.85 years (SD = 2.30; range = 10-19 years). CU traits were indexed via the Inventory for Callous Unemotional Traits (ICU). Region-wise volumetric parameters were obtained following parcellation …

Outcomes Of Adult Patients With Newly Diagnosed Idh-Mutated Aml Treated With Intensive Chemotherapy And Venetoclax, Jennifer Croden, Wei-Ying Jen, Jennifer Marvin-Peek, Lianchun Xiao, Ian M Bouligny, Sanam Loghavi, Gautam Borthakur, Naval G Daver, Hussein A Abbas, Koichi Takahashi, Koji Sasaki, Naveen Pemmaraju, Nicholas J Short, Danielle Hammond, Elias Jabbour, Lucia Masarova, Kelly S Chien, Ghayas C Issa, Guillermo Montalban-Bravo, Musa Yilmaz, Abhishek Maiti, Yesid Alvarado-Valero, Guillermo Garcia-Manero, Farhad Ravandi, Marina Y Konopleva, Hagop M Kantarjian, Tapan M Kadia, Courtney D Dinardo

Faculty, Staff and Student Publications

No abstract provided.

Physicochemical And Structural Optimization Of Date (Phoenix Dactylifera L.) Syrup: Impact Of Extraction Temperatures And Pectin Addition, Afna Thaivalappil Abdul Asiz

Theses

This thesis focuses on the optimization of date (Phoenix dactylifera L.) syrup, an emerging natural sweetener rich in glucose, fructose, and bioactive compounds, by investigating how extraction temperature and pectin incorporation influence its physicochemical and structural properties. Therefore, the main objective of this study was to examine how extraction temperatures (25°C, 50°C, 75°C, and 90°C), and the incorporation of lowmethoxyl pectin (LMP, DE 31%) and high-methoxyl pectin (HMP, DE 85%) prior to concentration, affect the quality, stability, and functionality of date syrup. The results showed that increasing extraction temperatures increased the total soluble solids (16 °Brix at 25°C to …

Cattle Funding Scheme 2023-24 Annual Report, Department Of Primary Industries And Regional Development, Western Australia

Biosecurity published reports

I am pleased to present the 2023-24 annual report for the Cattle Industry Funding Scheme (Cattle IFS) to our participants, key stakeholders in the Western Australian (WA) cattle industry, and the Minister for Agriculture and Food. This financial year has brought its share of challenges to the WA cattle industry including domestic and global markets, dry weather conditions and high biosecurity concerns. With Foot-and-mouth disease (FMD) and Lumpy Skin Disease (LSD) detected in Indonesia, biosecurity threats remain ever-present. As a result, maintaining the health of our herd in WA continues to be our top priority. The Cattle IFS continues to …

Bone Mineral Density Of Willow Ptarmigan (Lagopus Lagopus) As A Potential Taphonomic Factor In Skeletal Part Attrition, Frank J. Dirrigl Jr., Samuel R. Buchanan

School of Integrative Biological & Chemical Sciences Faculty Publications

Agents of taphonomy can bias skeletal parts and the frequency of bones in archaeological sites. An important factor to consider is the possible effect of bone density-mediated attrition on archaeornithological assemblages. We scanned willow ptarmigan (Lagopus lagopus) specimens using a Lunar iDXA and an enCcore small animal body add-on to develop a rank-order scheme based on the volumetric bone mineral density (vBMD) of skeletal parts. Our results identified the tibiotarsus and femur to be the least dense bones, while carpometacarpus, 3rd digit, and coracoid were the densest. This novel scheme allowed us to evaluate a sample of 22 …

Twenty-Four Year Record Reveals Increasing Discharge In Tributaries To A Key Drinking Water Resource, Shannon Speir, Ireyra G. Tamayo, Alana G. Strauss

Crop, Soil and Environmental Sciences Faculty Publications and Presentations

Climate change is altering precipitation patterns worldwide, yielding changes in streamflow and water availability. Increases in storm frequency and intensity, as well as prolonged droughts, may alter the timing and magnitude of flow and nutrient delivery to downstream systems, many of which serve as key drinking water resources. Thus, we must understand long-term changes in streamflow to protect drinking water supplies. Here, we document changes in streamflow delivery to Beaver Lake Reservoir, the key drinking water source in rapidly urbanising Northwest Arkansas. We used publicly available data to analyse flow records in four key tributaries to Beaver Lake from 2000 …

Proteomic Approaches To Investigate Pp2a-B55 Substrates And Cellular Function, Brennan C. Mcewan

Dartmouth College Ph.D Dissertations

Cell division is controlled in large part by reversible protein phosphorylation. The phosphorylation state of proteins during mitosis and other phases of the cell cycle represents a careful balance of activity between kinases and opposing phosphatases. The phosphoprotein phosphatase (PPP) family is responsible for the majority of serine and threonine dephosphorylation. Members of the PPP family are composed of a catalytic subunit paired with a regulatory subunit that targets them towards specific substrates.

The most abundant PPP, PPP2A, paired with its regulatory B55 subunit, is thought to be the phosphatase responsible for the dephosphorylation of substrates during mitotic exit. Despite …

Effects Of Heat Stress And Depressed Feed Intake On The Cecal And Ileal Microbiota Of Broiler Chickens, Philip M. Campos, Elizabeth S. Greene, Monika Proszkowiec-Weglarz, Sami Dridi

Poultry Science Faculty Publications and Presentations

Chronic heat stress (HS) is known to depress feed intake (FI) and growth in broiler chickens, and may alter the gut microbiota and health, however, the amplitude and duration of each (HS and depressed FI) effect on gut microbiota is still unclear. This study aimed to determine the effects of chronic and acute HS on the cecal and ileal microbiota profiles. Broilers were subjected to thermoneutral (TN, 23 degrees C) or chronic cyclic HS (CHS, 8 h/d, 35 degrees C) condition from d29-42, and one group to acute HS (AHS, 2 h, 35 degrees C) at d42. To distinguish between …

Integrating Food Loss And Waste Reduction Policies With Global Dietary Shifts: An Economic Modelling Study, Alessandro Gatto, Maksym Chepeliev

Department of Agricultural Economics Faculty Publications

Background

Methods

Cul3 Postnatal Homozygous Deletion In Forebrain Results In Behavioral Differences, Prathibha Sekar, Qiang‐Qiang Xia, Alex C. Stokes, Feiyu Quan, Jeffrey Singer, Craig M. Powell

Biology Faculty Publications and Presentations

Large-scale human genetic studies implicate multiple genes that regulate protein ubiquitination in autism spectrum disorder (ASD). De novo loss-of-function mutations in the gene CULLIN3 (CUL3) are implicated in autism and intellectual disability (ID). CUL3 is an essential component of an E3 ubiquitin ligase complex required for ubiquitination of substrates, often a signal for proteasomal degradation. Homozygous deletion of Cul3 is embryonically lethal. Recent studies show heterozygous deletion of Cul3 results in phenotypes with some face validity for autism in constitutive and conditional Cul3 heterozygotes. To understand the function of Cul3 in late postnatal development and function in the brain, we …

Dynamic Rewiring Of Microrna Networks In The Brainstem Autonomic Control Circuits During Hypertension Development In The Female Spontaneously Hypertensive Rat, Alison Moss, Ankita Srivastava, Lakshmi Kuttippurathu, James S. Schwaber, Rajanikanth Vadigepalli

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

We describe global microRNA (miRNA) changes in the central autonomic control circuits during the development of neurogenic hypertension. Using the female spontaneously hypertensive rat (SHR) and the normotensive Wistar Kyoto (WKY), we analyzed the dynamic miRNA expression changes in three brainstem regions-the nucleus of the solitary tract, caudal ventrolateral medulla, and rostral ventrolateral medulla-as a time series beginning at 8 wk of age before hypertension onset through to extended chronic hypertension. Our analysis yielded nine miRNAs that were significantly differentially regulated in all three regions between SHR and WKY over time. We collated computationally predicted gene targets of these nine …

Exploring The Transformative Effects Of Calorie Restriction On The Lacrimal Gland In Adult Mice, Olivier Mauduit, Prashant Kumar, Kaitlin K Scholand, Emre Aksan, Laura Schaefer, Anmar Abu-Romman, Vanessa Delcroix, Zhiyuan Yu, Aude I Sindikubwabo, Ron Korstanje, Helen P Makarenkova, Cintia S De Paiva

Faculty, Staff and Students Publications

Advanced age is one of the most recognizable risk factors for dry eye. Dry eye disease affects millions worldwide and can result from age-related lacrimal gland dysfunction, which correlates with a decline in lacrimal gland secretory cell function and chronic inflammation. This study investigated the potential of calorie restriction to maintain lacrimal gland and ocular surface health. Adult female C57BL/6 J mice were subjected to a 40% calorie restriction for 4 months, starting at 6-7 months and continuing until 10-11 months. These mice were compared to controls fed ad libitum. Bulk RNA sequencing of lacrimal glands, conjunctiva, and cornea subjected …

Nrf2 Hyperactivation As A Driver Of Radiotherapy Resistance And Suppressed Antitumor Immunity In Head And Neck Squamous Cell Carcinoma, Rutulkumar Patel, Kalil Saab, Lixia Luo, Yan Ma, Rashid Abdullah Osman, Nerissa T Williams, Jeffrey Everitt, Maciej J Zelazowski, Patricia Castro, William K Decker, William H Hudson, Jeffrey N Myers, Vlad C Sandulache, Mitchell J Frederick, Yvonne M Mowery, David G Kirsch

Faculty, Staff and Students Publications

Purpose: Alterations in the KEAP1/NFE2L2 (NRF2)/CUL3 pathway occur in ∼20% of human head and neck squamous cell carcinomas (HNSCC) and are associated with resistance to standard-of-care therapy. However, this pathway's role in radiotherapy resistance in HNSCC has not been well studied.

Experimental design: We generated genetically engineered mouse models and developed primary murine cancer cell lines harboring mutations commonly observed in human HNSCC, including inducible activation of PIK3CA and deletion of Trp53, with or without Keap1 loss. Primary tumors were initiated via 4-hydroxytamoxifen injection ± the tobacco carcinogen benzo[a]pyrene (BAP) into the oral buccal mucosa. Tumors were analyzed by Western …

Repeated Withdrawal Of A Glpr Agonist Induces Hyperleptinemia And Deteriorates Metabolic Health In Obese Aging Um-Het3 Mice, Nisi Jiang, Jiyuan Yin, Noah Lawrence, Jieyi Meng, Laurence T Maeyens, Ziying Xu, Xin Li, Mbolle Ekane, Ariana Chaudhary, Pengju Cao, Guannan Li, Carolina Solis-Herrera, Yi Zhu, Shangang Zhao

Children’s Nutrition Research Center Staff Publications

GLP-1-based therapy is highly effective in combating aging-associated metabolic diseases. However, the metabolic effects of frequent withdrawal from this therapy in aged, obese mice have not been previously studied. In this study, aged obese UM-HET3 mice were assigned to three groups: Group 1 received no liraglutide treatment (Lira OFF); Group 2 underwent 3 cycles of treatment followed by withdrawal (Lira ON/OFF); and Group 3 remained on continuous treatment (Lira ON). As expected, mice in Group 3 showed reduced body weight and food intake, along with improved metabolic health. In contrast, mice in Group 2 developed hyperleptinemia and visceral fat expansion, …

Plasma Proteome Correlations With Liver Stiffness In Pediatric Cholestasis Implicate Epithelial To Mesenchymal Transition, Benjamin L Shneider, Rupa S Kanchi, Sandra L Grimm, Sridevi Devaraj, Juliet Emamaullee, Jeremy Schraw, Philip J Lupo, Jorge A Bezerra, Kathleen M Loomes, John C Magee, Ronald J Sokol, Kasper S Wang, Alyssa Kriegmeier, Evelyn Hsu, Jean P Molleston, Philip Rosenthal, Rohit Kohli, Saul J Karpen, Simon P Horslen, M Kyle Jensen, Arianna Barbetta, Cristian Coarfa

Faculty, Staff and Students Publications

Background: Pediatric cholestatic liver diseases can be characterized by rapidly progressive fibrosis. A multicenter cross-sectional analysis of vibration-controlled elastography in biliary atresia (BA), alpha-1 antitrypsin deficiency (A1AT), and Alagille syndrome (ALGS) was leveraged to interrogate the plasma proteome relative to liver stiffness measurements (LSM).

Methods: Slow off-rate modified aptamer scanning profiling of >7000 proteins in plasma from 187 children with BA (n=93), A1AT (n=31), ALGS (n=46), and healthy pediatric controls (n=17) was performed, and correlations with LSM were undertaken.

Results: There was an abundance of LSM correlated proteins (BA n=2720, A1AT n=694, ALGS n=5968). Interestingly, a distinct plasma proteome was …

Integrating Multimodal Neuroimaging Of Error Monitoring To Estimate Future Anxiety In Adolescents, Emilio A. Valadez, Stefania Conte, John E. Richards, Yi Feng, Lucrezia Liuzzi, Marco Mcsweeney, Enda Tan, George A. Buzzell, Anderson M. Winkler, Daniel Samuel Pine

Human Genetics Publications

Importance Anxiety disorders are highly prevalent and associated with heightened error monitoring, the detection of one’s mistakes. However, error monitoring, anxiety, and their associations change throughout adolescence, limiting the ability to estimate future anxiety trajectories during this period.

Objective To ascertain whether measures of error monitoring obtained via the integration of electroencephalogram (EEG) and functional magnetic resonance imaging (fMRI) improve estimations of future anxiety compared with EEG or fMRI alone, in adolescents with or without a history of behaviorally inhibited temperament.

Design, Setting, and Participants This longitudinal cohort study was conducted at a university research laboratory and government research hospital. …