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Full-Text Articles in Entire DC Network
Ameliorative Effects And Mechanisms Of Crocetin On Insulin Resistance In High-Fat Diet-Induced Diabetic Mice, Wen Jing, Qin Si, Lyu Chenghao
Ameliorative Effects And Mechanisms Of Crocetin On Insulin Resistance In High-Fat Diet-Induced Diabetic Mice, Wen Jing, Qin Si, Lyu Chenghao
Food and Machinery
[Objective] To investigate the hypoglycemic, lipid-lowering, anti-inflammatory, and antioxidant effects of crocetin in high-fat diet (HFD)-induced diabetic mice, and to preliminarily explore its regulatory effects on hepatic insulin signaling pathways and protein S-nitrosylation levels. [Methods] An insulin resistance model was established in C57BL/6J mice by HFD feeding. Mice were administered low (5 mg/kg), medium (10 mg/kg), or high (20 mg/kg) doses of crocetin for 8 weeks, with metformin (200 mg/kg) used as a positive control. Fasting blood glucose, oral glucose tolerance, serum insulin, lipid profiles, hepatic oxidative stress, and inflammatory cytokines were measured. Western blot was used to detect phosphorylation …
Comparative Analysis Of Beef Quality From Bashan Region, Wan Xiaohui, Yao Pingbo, Zhang Duoduo, Ma Xiaowen, Tang Youxue, Liu Yongfeng
Comparative Analysis Of Beef Quality From Bashan Region, Wan Xiaohui, Yao Pingbo, Zhang Duoduo, Ma Xiaowen, Tang Youxue, Liu Yongfeng
Food and Machinery
[Objective] To clarify the unique quality of beef from the Bashan region. [Methods] Xizhen cattle beef from the eastern, southern, south-central, central, and northern regions of Zhenba County, Shaanxi Province, is taken as the material to investigate the differences in nutritional quality (moisture, protein, fat, and minerals) and eating quality (color, texture, and flavor). [Results] Zhenba beef has unique qualities, such as high protein and total mineral content, compared with the nutrient composition of beef in the food nutrient composition database published by the National Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention. For nutritional quality, …
Comparison And Optimization Of Glycoprotein Extraction Processes For Six Panax Medicinal Herbs Using Ultra-High Pressure Extraction Technology, Chang Fangyu, Zang Hao, Cheng Liye, Han Lusheng, Du Lianyun, Wang Enpeng
Comparison And Optimization Of Glycoprotein Extraction Processes For Six Panax Medicinal Herbs Using Ultra-High Pressure Extraction Technology, Chang Fangyu, Zang Hao, Cheng Liye, Han Lusheng, Du Lianyun, Wang Enpeng
Food and Machinery
[Objective] To comprehensively compare and screen glycoprotein preparation processes for six representative medicinal materials from the genus Panax. [Methods] Glycoprotein yield, DPPH radical scavenging capacity, hydroxyl radical scavenging capacity, and Fe2+ chelation inhibition rate were used as evaluation indicators. Glycoprotein extraction rates and antioxidant activities of six medicinal materials, including P. ginseng, P. notoginseng, P. quinquefolius, P. japonicus (T. Nees) C. A. Mey., P. stipuleanatus H. T. Tsai & K. M. Feng, and P. bipinnatifidus Seem, were compared using traditional thermal extraction and ultra-high pressure processing (UHPP). The Box–Behnken response surface method was employed to optimize UHPP parameters for P. …
Optimization Of Probiotic Fermentation Process And Effects Of Drying Methods On The Quality Of Sea Buckthorn Leaves, Dong Xiaoyue, Yun Xueyan, Zhang Lu, Dong Tongliga, Zhao Chenxi, Te Jinwei, Wang Xiukuan, Hao Qian, Miao Meishu, Su Ke
Optimization Of Probiotic Fermentation Process And Effects Of Drying Methods On The Quality Of Sea Buckthorn Leaves, Dong Xiaoyue, Yun Xueyan, Zhang Lu, Dong Tongliga, Zhao Chenxi, Te Jinwei, Wang Xiukuan, Hao Qian, Miao Meishu, Su Ke
Food and Machinery
[Objective] To investigate the effects of probiotic fermentation conditions and drying methods on the quality of fermented sea buckthorn leaf products. [Methods] Lactiplantibacillus plantarum is used for fermentation. The fermentation process of sea buckthorn leaves is optimized through single-factor experiments combined with response surface methodology. Fermented sea buckthorn leaf extract is prepared under the optimal fermentation conditions and subsequently processed into freeze-dried powder by direct freeze-drying and spray freeze-drying, with or without low-voltage electrostatic field assistance. The effects of different treatments on viable cell counts, flavonoid and polyphenol retention rates, water activity, and in vitro digestion characteristics are evaluated. [Results] …
Effect Of Modified Hemoglobin As A Substitute For Sodium Nitrite On The Quality Of Ham Sausage, Qu Shulei, Ma Chao, Yao Xianqi, Du Dongxu, Wang Wei, Liu Yunguo
Effect Of Modified Hemoglobin As A Substitute For Sodium Nitrite On The Quality Of Ham Sausage, Qu Shulei, Ma Chao, Yao Xianqi, Du Dongxu, Wang Wei, Liu Yunguo
Food and Machinery
[Objective] To improve the utilization rate of porcine blood and the safety of ham sausage. [Methods] Under specific conditions, hemoglobin in porcine blood is modified to produce glycosylated nitrosohemoglobin (GN-Hb). Different amounts of GN-Hb are added to replace sodium nitrite in heat-treated ham sausages. The quality characteristics of the sausages are evaluated through texture analysis, nutritional testing, color difference assessment, color acceptability, elasticity, chewiness, and overall acceptability. [Results] When the sodium nitrite dosage is 100 mg/kg and the GN-Hb dosage is 2.5 g/kg, high-temperature sterilized ham sausage containing the new pigment shows significant improvement in color and cohesion compared with …
Extraction Process Optimization Of Camellia Sinensis Flavonoids And Their Antioxidant Activity, Tu Jianqiu, Xu Danhe, Chen Long, Wang Yaxin, Xu Jiahui, Jing Lixiang, Li Jianfang
Extraction Process Optimization Of Camellia Sinensis Flavonoids And Their Antioxidant Activity, Tu Jianqiu, Xu Danhe, Chen Long, Wang Yaxin, Xu Jiahui, Jing Lixiang, Li Jianfang
Food and Machinery
[Objective] To optimize the extraction process of flavonoids from Xinyang Camellia sinensis and to compare the in vitro antioxidant activities of total flavonoids before and after purification. [Methods] Using Xinyang C. sinensis as raw material, a one-factor test is conducted to investigate the effects of ethanol volume fraction, ultrasonic time, ultrasonic power, and material–liquid ratio on the yield of flavonoids. Subsequently, a three-factor, three-level optimization model is established based on the Box–Behnken experimental design. Additionally, a macroporous adsorption resin is utilized for the purification of flavonoid crude extracts. Finally, the in vitro antioxidant activity of the total flavonoids is evaluated …
Research Progress In Production Process And Flavor Modulation Mechanisms Of Cooking Wine, An Nan, Liu Gongliang, Bai Weidong, Tong Xing, Wang Hong
Research Progress In Production Process And Flavor Modulation Mechanisms Of Cooking Wine, An Nan, Liu Gongliang, Bai Weidong, Tong Xing, Wang Hong
Food and Machinery
As a core condiment in traditional Chinese cuisine, the flavor modulation mechanisms of cooking wine are closely related to its production processes. This review systematically organizes the three major production systems of cooking wine, i.e., brewed, blended, and seasoned, comparing their differences in base-wine origin, flavor-formation pathways, and product stability. By integrating the latest developments in flavoromics, molecular interactions, and intelligent fermentation, it provides a systematic analysis of the relationship between production process differences and flavor formation mechanisms. The paper clarifies the multi-stage “dissolution–modification–suppression” mechanism for off-flavor removal and proposes a metabolic flux-directed process optimization pathway. Additionally, it explores the …
Progress On The Nutrient Components, Functional Activities, And Utilization Of Dictyophora Rubrovalvata, Zhang Lunqing, Wang Xianxing, Li Qiaoqiao, Xu Cunbin, Wang Yu
Progress On The Nutrient Components, Functional Activities, And Utilization Of Dictyophora Rubrovalvata, Zhang Lunqing, Wang Xianxing, Li Qiaoqiao, Xu Cunbin, Wang Yu
Food and Machinery
Dictyophora rubrovalvata, a valuable edible fungus in China, is rich in active components such as polysaccharides, proteins, amino acids, and vitamins, exhibiting significant efficacy in antioxidant, anti-fatigue, antitumor, immunomodulatory, hepatoprotective, and anti-inflammatory activities. This paper systematically reviews recent research progress on the nutritional components, functional activities, and utilization status of D. rubrovalvata, both in China and elsewhere, with an outlook on its future development directions and application prospects.
A Review Of Metabolic Mechanisms Of N-Nitroso Compounds And Measures For Their Reduction And Control, Wang Zhulin
A Review Of Metabolic Mechanisms Of N-Nitroso Compounds And Measures For Their Reduction And Control, Wang Zhulin
Food and Machinery
N-nitroso compounds, as one of the major food contaminants, are widely present in food and pose hazards such as carcinogenicity, teratogenicity, and mutagenicity, thus being a key focus in food safety monitoring. Although significant progress has been made in the research on N-nitroso compounds, studies on their metabolic mechanisms and reduction and control measures are still disconnected to a certain extent. Through a review of the classification, detection methods, and toxic effects of N-nitroso compounds, this article analyzes the intrinsic connection between their metabolic pathways in the body and strategies for external reduction and control, aiming to provide theoretical references …
Interactive Mechanism Of Food Packaging Design And Children's Health Consciousness, Yang Qian
Interactive Mechanism Of Food Packaging Design And Children's Health Consciousness, Yang Qian
Food and Machinery
Food packaging can establish an “entertainment–knowledge–action” interactive closed-loop mechanism for children, effectively guiding them to practice healthy behaviors, overcoming the low efficiency of conventional text- and image-based instruction, and continuously strengthening their health awareness. At present, interactive design for cultivating children’s health awareness through food packaging is constrained by superficial forms of interaction, insufficient integration of entertainment functions, fragmented system construction, and the absence of educational mechanisms in the implementation stage. The “entertainment–knowledge–action” closed-loop design can specifically address the limitations of traditional packaging, including fragmented interaction, superficial cognition, and weak behavioral guidance. Specifically, entertainment serves as the entry point by …
Consumer Judgment, Choice, And Meaning-Making In Food Packaging Design From The Perspective Of Consumption Alienation, Guo Jingzhi, Xu Ming
Consumer Judgment, Choice, And Meaning-Making In Food Packaging Design From The Perspective Of Consumption Alienation, Guo Jingzhi, Xu Ming
Food and Machinery
In the context of contemporary food consumption, food packaging has gradually shifted from a tool for product protection and information transmission to an important cognitive interface that influences consumer perception, judgment, and choice. Existing studies in this field mainly focus on functional optimization, behavioral guidance, and cultural expression, while insufficient attention has been paid to how packaging design affects consumer cognitive processes. This paper introduces the theoretical perspective of consumption alienation and employs literature analysis and comparative case studies to construct a three-layer analytical framework of “judgment–choice–meaning.” Furthermore, it proposes a regression-based analytical pathway centered on comprehensibility, choice support, and …
Sources And Potential Risks Of Micro- And Nanoplastics In Foods, Zhao Xinlong, Li Wei, Zhang Mengling, Xing Liwen, Tian Huafeng
Sources And Potential Risks Of Micro- And Nanoplastics In Foods, Zhao Xinlong, Li Wei, Zhang Mengling, Xing Liwen, Tian Huafeng
Food and Machinery
Plastics are widely used in food packaging, storage, processing, and other food-related applications, playing a vital role in extending food shelf life, reducing material loss, and promoting food circulation. However, these plastic products that come into direct or indirect contact with foods can release micro- and nanoplastics through various physical and chemical processes. These micro- and nanoplastics can accumulate in the human body through bioaccumulation and other pathways and have become one of the emerging contaminants threatening food safety and human health. This review provides a comprehensive summary of the research progress on the generation pathways, release mechanisms, potential health …
Advances In The Application Of Electroencephalography In Food Sensory Science, Li Wenbin, Hou Xiaoyi, Deng Na, Leng Tuo, Fu Haohua, Wang Jianhui
Advances In The Application Of Electroencephalography In Food Sensory Science, Li Wenbin, Hou Xiaoyi, Deng Na, Leng Tuo, Fu Haohua, Wang Jianhui
Food and Machinery
Traditional sensory evaluation of food is affected by subjectivity and other factors, resulting in significant limitations. Electroencephalography (EEG), owing to its advantages of high temporal resolution, non-invasiveness, and real-time dynamic monitoring, offers an objective neurophysiological perspective and analytical approach to address this issue, effectively advancing food science research from subjective descriptions to objective neural decoding. This paper systematically reviews the applications of EEG in food flavor recognition and prediction, objective evaluation of food quality, and analysis of food nutrition and consumer behavior. In light of the current state of technological development, it is proposed that multimodal technology integration and machine …
Using “You” As A Subject In Biology Assessment Questions: Examining Student Preferences For Second-Person Framing, Noelle Clark, Kate Hill, Jeremy L. Hsu
Using “You” As A Subject In Biology Assessment Questions: Examining Student Preferences For Second-Person Framing, Noelle Clark, Kate Hill, Jeremy L. Hsu
Biology, Chemistry, and Environmental Sciences Faculty Articles and Research
In college biology courses, exams and quizzes are often used to assess students’ knowledge and performance. Since assessments are a crucial part of biology classes, there has been a wide range of work examining how assessment questions are written, revealing that small changes in how such questions are worded may have large impacts on students’ reading comprehension and performance. One aspect that instructors consider when writing a question is subject framing, i.e., which individual, if any, is being placed as the focal point of the question. In this study, we focus on the following subject framings, an authentic scientist, a …
Impact Of Social Media-Driven Feeding Practices On The Gut Microbiome Of Captive Asian Elephants (Elephas Maximus) In Surin, Thailand, Pongpreecha Malaluang, Nuttapon Bangkaew, Jaruwan Chaiyakhot, Patinya Patikae, Nattaya Watwiengkam, Phimphanit Choklikitumnuey, Thanaphat Phupanna, Sudachanok Phowiset, Prim Chuesaard, Tarid Purisotayo
Impact Of Social Media-Driven Feeding Practices On The Gut Microbiome Of Captive Asian Elephants (Elephas Maximus) In Surin, Thailand, Pongpreecha Malaluang, Nuttapon Bangkaew, Jaruwan Chaiyakhot, Patinya Patikae, Nattaya Watwiengkam, Phimphanit Choklikitumnuey, Thanaphat Phupanna, Sudachanok Phowiset, Prim Chuesaard, Tarid Purisotayo
The Thai Journal of Veterinary Medicine
This study investigated the effects of social media-driven live-streaming dietary supplementation on the gastrointestinal microbial community of captive Asian elephants (Elephas maximus) at the Elephant Kingdom, Surin Province, Thailand. A hierarchical two-tier observational design was used: Tier 1 compared a minimal-supplementation control group (Group H, n = 6) with a frequent heterogeneous-supplementation group (Group L, n = 18); Tier 2 compared, within Group L, low-frequency (Group A, ≤ 3 sessions per week, n = 7) and high-frequency (Group B, > 3 sessions per week, n = 11) live-streaming sub-groups. Faecal microbial profiles were obtained by 16S rRNA gene (V3–V4) …
Science, Uncertainty, And Stewardship: Climate Change Viewpoints In Higher Education, Jamie Jensen, Isaiah Aduse-Poku
Science, Uncertainty, And Stewardship: Climate Change Viewpoints In Higher Education, Jamie Jensen, Isaiah Aduse-Poku
ScholarsArchive Data
This dataset supports a Q-methodology study of climate change viewpoints among undergraduate students at Brigham Young University. Participants were recruited from an introductory non-majors biology course during Fall 2025. The study examined how students organized climate-change views across scientific evidence, human causation, uncertainty, political beliefs, religious stewardship, moral responsibility, perceived agency, climate policy, and future risks.
Understanding The Effects Of Simulated Microgravity On Staphylococcus Epidermidis And Escherichia Coli In Co-Culture, Emma Costa, Mitchell K. Villafania, Makaila Olson, Kareigh N. Gammon, Hugo Castillo
Understanding The Effects Of Simulated Microgravity On Staphylococcus Epidermidis And Escherichia Coli In Co-Culture, Emma Costa, Mitchell K. Villafania, Makaila Olson, Kareigh N. Gammon, Hugo Castillo
Beyond: Undergraduate Research Journal
With the popularity of space travel increasing, it is important to understand the effects of microgravity on microbial communities as alterations on bacterial interactions can occur. Staphylococcus epidermidis and Escherichia coli are bacteria that are commonly found within human microbiomes. S. epidermidis is a cocci-shaped gram-positive bacterium that is part of the human skin microbiome. However, it can gather on sites of open skin and enter the body leading to an infection. E. coli is a rod-shaped gram-negative bacterium that can be found in the human gut microbiome. The pathogenic strains of E. coli have the potential to cause harmful …
Signal And Substance: Why Methodological Sophistication Fails To Guarantee Inference, Aamir Rashid, Rizwana Rasheed
Signal And Substance: Why Methodological Sophistication Fails To Guarantee Inference, Aamir Rashid, Rizwana Rasheed
Publications and Research
Despite increasing analytical sophistication, empirical research in organization studies continues to suffer from fragile inference, uneven theoretical accumulation, and contested credibility. This paper seeks to explain why these problems persist by shifting attention from authors’ methodological choices to the evaluative dynamics of peer review. Adopting a conceptual and theory-analytic approach, the paper theorizes peer review as an inferential gatekeeping system. Drawing on research design, theory evaluation, and philosophy-of-science literatures, this study develops an analytical framework to examine how evaluative routines shape what constitutes empirical rigor during the review process. The analysis identifies five recurring reviewer blind spots: inferential scope inflation, …
Effectiveness Of Organic Amendments In Enriching Nitrogen In Compost Produced From Organic Fractions Of Market Waste Generated In Dar Es Salaam, Tanzania, Amani Bilula, Ally Mahadhy, Anthony Manoni Mshandete, Amelia Kivaisi
Effectiveness Of Organic Amendments In Enriching Nitrogen In Compost Produced From Organic Fractions Of Market Waste Generated In Dar Es Salaam, Tanzania, Amani Bilula, Ally Mahadhy, Anthony Manoni Mshandete, Amelia Kivaisi
Tanzania Journal of Science
Low nitrogen (N) content remains a key limitation of compost derived from urban organic waste. This study evaluated the effectiveness of selected plant-based organic amendments in enhancing nitrogen content and improving compost quality. Four plant- based organic amendments, Leucaena leucocephala (BN01), Commelina benghalensis (BN02), Morus alba (BN03), and Helianthus annuus (sunflower) cake (BN04), were incorporated into market waste compost at ratios of 1:0.06:0.04, 1:0.06:0.25, and 1:0.06:0.5 (organic waste: sawdust: amendment). Composting was conducted using a 4 × 3 factorial design with three replicates per treatment (n = 36). Temperature, moisture, and pH were monitored throughout the composting period. Total nitrogen, …
Nutritive Values Of Three Edible Green Seaweeds Collected From Dar Es Salaam Coast, Tanzania, Amelia S. Buriyo, Denis Gahunde, Kristian M. Kitali, David C. Simiyu
Nutritive Values Of Three Edible Green Seaweeds Collected From Dar Es Salaam Coast, Tanzania, Amelia S. Buriyo, Denis Gahunde, Kristian M. Kitali, David C. Simiyu
Tanzania Journal of Science
Tanzania is endowed with different seaweed (macroalgae) species, found abundantly along the coastline. Most of these hold a great potential as nutritious food sources with promising applications in food industry. These seaweeds could be highly utilized for effective management of the high levels of malnutrition in the country. Nonetheless, the nutritional potential of most seaweeds occurring in Tanzania is still unknown. Understanding the nutritional value of the commonly available edible seaweeds, could be an important step towards promoting them as food supplements in the country. In this study, the nutritive values (crude proteins, total carbohydrates, lipids, crude fibre, vitamins, and …
Tips For Growing Garden Vegetables In Utah: Soil Preparation, Gastone Makalaya, Josh Martin, Milena Oliveira
Tips For Growing Garden Vegetables In Utah: Soil Preparation, Gastone Makalaya, Josh Martin, Milena Oliveira
All Current Publications
To help Utah gardeners maintain healthy soils and enhance early vegetable production, this fact sheet provides practical guidance and tips on soil preparation for vegetable gardening.
Decoding The Allosteric Grammar Of Protein Kinases: A Dual-Stream Framework Integrating Protein Language Models And Energy Landscape Frustration Analysis, Will Gatlin, Max Ludwick, Lucas Turano, Brandon Foley, Kamila Riedlova, Vít Škrhák, Marian Novotný, David Hoksza, Gennady M. Verkhivker
Decoding The Allosteric Grammar Of Protein Kinases: A Dual-Stream Framework Integrating Protein Language Models And Energy Landscape Frustration Analysis, Will Gatlin, Max Ludwick, Lucas Turano, Brandon Foley, Kamila Riedlova, Vít Škrhák, Marian Novotný, David Hoksza, Gennady M. Verkhivker
Mathematics, Physics, and Computer Science Faculty Articles and Research
The spatial and energetic encoding of allosteric regulatory sites remains a major challenge in structural biology, frequently representing a “blind spot” for sequence-based artificial intelligence (AI) models. We present a protein language model (PLM)-guided approach complemented by the energy landscape frustration analysis as a dual-stream framework to investigate the relationship between AI prediction of binding sites and biophysical organization of regulatory pockets across the human kinome. By probing a fine-tuned residue-level PLM classifier across 453 kinase structures, a clear performance gap is discovered between highly predictable orthosteric pockets (Types I, I.5, and II) and poorly resolved distal allosteric sites (Type …
Rearing Of Lambs On Intensively Managed Pastures In The Carpathian Region And Its Problems, Jozef Habovstiak
Rearing Of Lambs On Intensively Managed Pastures In The Carpathian Region And Its Problems, Jozef Habovstiak
IGC Proceedings (1977-2023)
One of the patterns of utilizing the good productivity of grass stands in the Carpathian region consists in the intensive rearing of lambs in a pasture system. In the individual pasture farms, 350 to 700 kg of meat per ha were produced over a grazing period of 130 to 150 days. A very important factor in this pasture system is the planning of technical equipment (fences, sheds, etc.). The most critical problem is, however, to keep the lambs in good health. In each pasture farm, therefore, periodical veterinary attendance and strict sanitary arrangements must be integral parts of the fight …
Avian Conservation And Translocations In The Mariana Archipelago, John V. Bender
Avian Conservation And Translocations In The Mariana Archipelago, John V. Bender
Dissertations
Island birds are among the world’s most imperiled vertebrates, and conservation translocations are increasingly used to combat threats, but their success depends on understanding the mechanics of whether and how to conduct translocations effectively. In the Commonwealth of the Northern Mariana Islands, native forest birds persist across a chain of islands where habitat degradation and loss, invasive species, and extreme weather create persistent conservation challenges. For my dissertation, I investigated how avian conservation programs and translocations can be planned, implemented, and improved under biological, logistical, and social uncertainty. For Chapter 1 I analyzed 15 years of avian translocations across seven …
Defining Life: A Conversation, K. Kofman, C. Adami, F. Baluška, J. Bongard, D. Brash, P. Calvo, G. Dodig-Crnkovic, P. Das, C. Fields, T. Froese, P. L. Gentili, G. Y. Georgiev, Scott F. Gilbert, T. N. W. Jackson, S. Kauffman, N. Lane, P. Marshall, D. Mcshea, W. Miller, S. Newman, A. Nunn, T. P. Pavlic, M. Picard, W. Ratcliff, A. Reber, J. Shapiro, A. Sloman, R. Solé, C. Sonnenschein, S. Stepney, R. Watson, O. Witkowski, M. Levin
Defining Life: A Conversation, K. Kofman, C. Adami, F. Baluška, J. Bongard, D. Brash, P. Calvo, G. Dodig-Crnkovic, P. Das, C. Fields, T. Froese, P. L. Gentili, G. Y. Georgiev, Scott F. Gilbert, T. N. W. Jackson, S. Kauffman, N. Lane, P. Marshall, D. Mcshea, W. Miller, S. Newman, A. Nunn, T. P. Pavlic, M. Picard, W. Ratcliff, A. Reber, J. Shapiro, A. Sloman, R. Solé, C. Sonnenschein, S. Stepney, R. Watson, O. Witkowski, M. Levin
Biology Faculty Works
Life is one of the most fascinating features of the physical world. Despite centuries of scientific study, experts still disagree about the definition, and even the possibility or utility of a definition, of this field. In a recent paper, we used AI to analyze the conceptual space formed by definitions of life given by a select set of modern workers in the life sciences and related fields. However, some of the most interesting material emerged as real-time conversations among those polled. In order to ensure that these ideas are not lost to the peer-reviewed scientific record, we here provide a …
Online Decoding Of Rat Self-Paced Locomotion Speed From Eeg Using Recurrent Neural Networks, Alejandro De Miguel, Nelson Totah, Uri Maoz
Online Decoding Of Rat Self-Paced Locomotion Speed From Eeg Using Recurrent Neural Networks, Alejandro De Miguel, Nelson Totah, Uri Maoz
Psychology Faculty Articles and Research
Objective. Accurate and reliable neural decoding of locomotion holds promise for advancing clinical applications such as rehabilitation and prosthetic control, as well as for understanding neural correlates of action. Recent studies have demonstrated successful decoding of locomotion kinematics across species in motorized treadmill settings. However, efforts to decode locomotion speed directly and continuously in more natural contexts—where pace is self-selected rather than externally imposed—are scarce, and those that exist generally achieve only modest accuracy and require intracranial implants. Here, we aim to decode self-paced locomotion speed non-invasively and continuously using cortex-wide electroencephalography (EEG) recordings from rats. Approach. We introduce an …
Integrating Nutrition And Stress Into Life History Stages Of Wild Free-Ranging Female Pronghorn, Cole A. Bleke, Eric M. Gese, Juan J. Villalba, Shane B. Roberts, Susannah S. French
Integrating Nutrition And Stress Into Life History Stages Of Wild Free-Ranging Female Pronghorn, Cole A. Bleke, Eric M. Gese, Juan J. Villalba, Shane B. Roberts, Susannah S. French
Wildland Resources Student Research
Studies addressing seasonal changes in diet quality and hormones are important for understanding the interactions between ecology and physiology. We collected fecal samples from free-ranging adult female pronghorn (Antilocapra americana) to examine the relationships between indicators of nutrition and glucocorticoid activity. This occurred during three population-level, life-history-correlated sampling periods across five subpopulations. We evaluated nutrition via fecal nitrogen, fecal 2,6-diaminopimelic acid (DAPA), and assessed glucocorticoid activity using fecal glucocorticoid metabolites (FGM). We found positive relationships between fecal nitrogen and DAPA, whereas DAPA and fecal nitrogen with FGM varied in influence and strength, depending upon life history stage. Generally, …
Advances In Gene Editing Strategies For Viral Disease Resistance In Pigs: Knock-Out, Knock-In, And Overexpression Approaches, Zhao Namula, Takeshige Otoi, Aya Nakai, Megumi Nagahara, Maki Hirata, Fuminori Tanihara
Advances In Gene Editing Strategies For Viral Disease Resistance In Pigs: Knock-Out, Knock-In, And Overexpression Approaches, Zhao Namula, Takeshige Otoi, Aya Nakai, Megumi Nagahara, Maki Hirata, Fuminori Tanihara
The Thai Journal of Veterinary Medicine
Highly contagious viral pathogens—such as porcine reproductive and respiratory syndrome, classical swine fever, and African swine fever—continue to pose serious threats to the swine industry and cause major global economic losses. Conventional disease control approaches, such as vaccination and biosecurity, are limited by viral heterogeneity and immune escape mechanisms. Gene editing technologies, most notably the CRISPR/Cas9 system, offer an innovative means of introducing innate viral disease resistance or resilience in pigs. The continuous improvement of these tools can provide a sustainable strategy to enhance animal welfare and global food security and reduce reliance on traditional control measures. This review provides …
Hemidiaphragmatic Segmental Zoster Paresis, Terrence Sanvictores, Johnson Ukken
Hemidiaphragmatic Segmental Zoster Paresis, Terrence Sanvictores, Johnson Ukken
School of Medicine Faculty Research
The reactivation of latent varicella-zoster virus within infected neurons can lead to common clinical manifestations, including rash, acute neuritis, post-herpetic neuralgia, herpes zoster ophthalmicus, and Ramsay–Hunt syndrome. Segmental zoster paresis is an unusual neurologic complication of shingles that is defined by focal asymmetric motor weakness in the myotome corresponding to skin lesions of the dermatome. This case is a presentation of a patient who developed chronic hypoxia and severe atelectasis attributed to right-sided phrenic nerve paralysis secondary to herpes zoster infection.
Biophysical Insights Into A Cryptic Ligand Site In The Hydrophobic Core Of Human Pcna, Alexis N. Dispensa, Sharon N, Greenwood, Jason Yang, Daniel E. Logatto, James Fusco, E. Railey White, Roderic G. Eckenhoff, Zhiwei Liu, Brian P. Weiser
Biophysical Insights Into A Cryptic Ligand Site In The Hydrophobic Core Of Human Pcna, Alexis N. Dispensa, Sharon N, Greenwood, Jason Yang, Daniel E. Logatto, James Fusco, E. Railey White, Roderic G. Eckenhoff, Zhiwei Liu, Brian P. Weiser
Department of Anesthesiology Faculty Papers
Proteins contain small pockets that form due to imperfections in residue packing or the rotational and conformational movement of amino acids. In this work, we used the fluorescent probe 1-aminoanthracene (AMA) to detect a small ligand pocket in the hydrophobic core of human proliferating cell nuclear antigen (PCNA), which is a critical protein for DNA replication and repair. Fluorescence measurements of AMA reported that the core of PCNA had a dielectric constant (ε) of 4, which was very apolar and similar to cyclohexane (ε = 2). Protein mutagenesis, photoaffinity labeling, and molecular dynamics simulations localized the binding site for AMA …