Digital Commons Network^™

A Hybrid Geospatial And Remote Sensing Methodology For Drought Vulnerability Assessment In Semi-Arid Ecosystems, Kaifi Fakhir Chomani

Mansoura Engineering Journal

The Kurdistan Region of Iraq (KRI) faced significant drought challenges due to global and environmental changes, necessitating drought assessments. Advanced techniques of remote sensing, Geographic Information Systems (GIS), and Analytic Hierarchy Process (AHP) were combined in this research to perform drought vulnerability zonation for KRI. Average annual rainfall, Average number of rainy days, Average annual temperature, slope, elevation, normalised difference water index (NDWI), normalised difference vegetation index (NDVI), land surface temperature (LST), and temperature condition index (TCI) were selected as contributing parameters for drought vulnerability assessments. The considered parameters were weighted using pairwise comparison, and thematic maps were created to …

Self-Lubricating Nano-Coatings For Tribological Applications: Materials, Mechanisms, And Ai-Driven Design Approaches, Viral Panara, Vikas Panchal, Satayu Travadi, Harmish Bhatt, Madhav Oza

Mansoura Engineering Journal

Self-lubricating coatings with nanostructured structures are becoming crucial in order to decrease friction and wear in critical tribological systems like precision tools, biomedical implants, aerospace actuators, and engines. In this review, the most representative nano-engineered solid lubricants such as transition metal dichalcogenides, diamond-like carbon, hexagonal boron nitride, graphene, MXenes and hybrid multilayer architectures are discussed. The focus of the discussion is on the most important tribological mechanisms like lamellar sliding, oxidative adaptation, tribofilm formation, transfer-film development, and nano-asperity contact evolution. It also summarizes the most significant deposition techniques, such as cathodic arc physical vapor deposition, chemical vapor deposition, plasma-based deposition, …

Estrogen Deprivation During Primate (Papio Anubis) Pregnancy: Impact On Systemic Microvascular Flow And Cardiovascular Development And Function After Birth In Offspring, Sifa Turan, Jeffery S. Babischkin, Graham W. Aberdeen, Gerald J. Pepe, Eugene D. Albrecht

Department of Biomedical and Translational Sciences Faculty Publications

Background

Suppressing estradiol (E₂) during baboon pregnancy lowers offspring skeletal muscle capillary density, vital for insulin-mediated glucose uptake, and induces insulin resistance. We examined whether E₂ deprivation also impairs microvascular flow and cardiac function.

Methods

Offspring of untreated baboons, letrozole-treated baboons, or letrozole plus E₂ (maternal s.c. injections during the second half of gestation) underwent contrast-enhanced microbubble ultrasonography to quantify microvessel flow and echocardiography to assess cardiac performance.

Results

Letrozole reduced maternal serum E₂ by 95% (p <  0.01). In letrozole offspring, microbubble flux rate (β) fell 55% (p <  0.02), replenishment was 5 s slower (p <  0.03), and microvessel flow declined 40% (p = 0.05); all were restored by added E₂. Indices of systolic (isovolumic contraction), diastolic (isovolumic relaxation), global performance (Tei index), and cardiac output were unchanged.

Conclusion

Prolonged gestational E₂ deprivation programs a reduction in microvascular flow without altering cardiac function; maternal E₂ prevents this, supporting E₂'s role in …

Brief Pulses Of High-Level Fluid Shear Stress Enhance Metastatic Potential And Rapidly Alter The Metabolism Of Cancer Cells, Amanda N. Pope, Devon L. Moose, Guy O. Hudson, Hank R. Weresh, Marion R. Dykstra, Aabha Y. Joshi, Patrick Breheny, Eric B. Taylor, Michael D. Henry

Department of Biomedical and Translational Sciences Faculty Publications

Circulating tumor cells (CTCs) face challenges to their survival, including mechanical and oxidative stresses that are different from cancer cells in solid primary and metastatic tumors. The impact of adaptations to the fluid microenvironment of the circulation on the outcome of the metastatic cascade is not well understood. Here, we find that cancer cells exposed to brief pulses of high-level fluid shear stress (FSS) exhibit enhanced invasiveness and anchorage-independent proliferation in vitro and enhanced metastatic colonization/tumor formation in vivo. Cancer cells exposed to FSS rapidly alter their metabolism in a manner that promotes survival by providing energy for cytoskeletal remodeling …

Comparative Mass Spectrometry Analysis Of High And Low Centrifugation Extracellular Vesicle (Ev) Pellets From Healthy Urine Following Tamm-Horsfall Protein Removal, Dana Bielopolski, Luca Musante, Henrik Molina, Douglas Barrows, Samantha Upson, Lifang Yang, Thomas Carrol, Jonathan N. Tobin, Rhonda G. Kost, U. Erdbrügger

Department of Biomedical and Translational Sciences Faculty Publications

Objectives

Urinary extracellular vesicles (uEVs) are potential biomarkers for renal physiology and disease. Their isolation is challenged by Tamm-Horsfall protein (THP) contamination, particularly in high-speed ultracentrifugation (P100) fractions. Low-speed (P20) fractions contain biologically relevant uEVs, yet their proteomic composition is underexplored. This study evaluates strategies for THP removal to optimize mass spectrometry analysis and characterizes P20 and P100 uEV proteomes and its combination in healthy urine.

Methods

Urine from a healthy volunteer was processed via sequential centrifugation at 21,200 g (P20) and 164,244 g (P100). THP removal was performed using low ionic strength buffer (P20) and size-exclusion chromatography (P100). Western …

The Role Of Dromedary Camels In The Pprv Epidemiology: Episystem Possibility And Evidence Supporting Global Eradication., Reham Karam, Mahmoud S. Safwat

Mansoura Veterinary Medical Journal

Background: Peste des petits ruminants (PPR) is a notifiable, highly contagious and transboundary viral disease infecting a wide range of domestic and wild ruminant species and is caused by a morbillivirus. The disease represents a major predisposing factor of poverty in many endemic regions. Although global eradication of PPR is an internationally endorsed objective, achieving this goal has become increasingly challenging due to the expanding host range of the virus. Methods: Narrative review methodology was used and SANRA criteria to access reliability and quality of the methodology. focuses on PPR infection in camels, which has been reported in some instances …

Tracking Antibiotic Resistant And Multidrug Resistant Bacteria And Antibiotic Resistance Genes In The Huron River Watershed: A Vital Water Resource In Southeast Michigan, Evan Siemienkiewicz

Master's Theses and Doctoral Dissertations

Antibiotic resistance is a growing global public health concern that extends beyond clinical settings and into natural freshwater environments, where resistant bacteria and antibiotic resistance genes (ARGs) can persist and disseminate through watersheds. Despite growing recognition of freshwater systems as environmental reservoirs of resistance, no published studies have examined antibiotic resistance within the Huron River watershed in Southeast Michigan. Water samples were collected monthly from May through October 2025 at 10 sites along the Huron River. E. coli and Enterococcus isolates were evaluated for resistance to eight antibiotics using the Kirby-Bauer disk diffusion method, and environmental DNA was analyzed by …

A Cross-Species Meta-Analysis Of Environmental Enrichment Effects On Cognition, Greg S. Fitzgerald

Electronic Theses & Dissertations (2024 - present)

Environmental enrichment --providing animals or people with stimulating, complex surroundings --consistently improves cognitive performance in laboratory rodents. But when similar interventions are tested in humans, the benefits are much smaller. Understanding why matters: if researchers overestimate how well rodent findings will translate, it can mislead expectations for human cognitive interventions.

This dissertation presents the first cross-species meta-analysis comparing environmental enrichment effects on cognition between rodent and human studies. Drawing on 121 studies (71 rodent, 50 human) contributing 478 effect sizes, the analysis used multilevel models with variance correction to account for the statistical dependence created when studies report multiple outcomes. …

Stem Cell-Derived Developmental Models For Translational Evaluation Of Disease And Therapy, Maria B. Paredes-Espinosa

Electronic Theses & Dissertations (2024 - present)

Human development as well as congenital and adult diseases emerge from coordinated interactions among multiple cell types, regulatory programs, and tissue compartments that remain largely unresolved. Conventional simple lineage-restricted in vitro systems poorly capture this complexity. My dissertation uses human stem cell-derived developmental models to study human cardiac morphogenesis and heart diseases and application of a networked neuron platform to explore senescence-associated neurodegeneration impact on Alzheimer’s neurons.

Elongating multi-lineage organized cardiac (EMLOC) gastruloids are a synthetic embryology model that co-generates contractile cardiomyocyte populations alongside mesenchymal, endothelial, epicardial-like, neural crest-associated, and neuronal cells within a shared in vitro developmental environment. Single-cell …

From Nesting To Emergence: Environmental Drivers Of Hatchling Success In Blanding’S Turtles And Implications For Management In Southeast Michigan, Morgan Boyer

Master's Theses and Doctoral Dissertations

Blanding’s turtles (Emydoidea blandingii) are long-lived turtles whose populations are highly sensitive to juvenile recruitment. We used intensive nest monitoring, microclimate logging, soil measurements, and local weather data at two Southeast Michigan sites to quantify how nest placement, incubation environments, and substrate conditions influence emergence success and hatchling condition. Nesting females were morphologically similar in size and produced average clutch sizes for the species (8 ± 2 eggs). Nest sites were found on relatively open, disturbed uplands with sandier soil substrates. Emergence success was generally high (≈ 70-80%) in nests protected from predation. Sandy loam had the highest success rates …

Prolonged Qt Interval In Hiv-1 Infected Humanized Mice Treated Chronically With Dolutegravir/Tenofovir Disoproxil Fumarate/Emtricitabine, Ali Namvaran, Julian V. Garcia, Mahendran Ramasamy, Kayla Nguyen, Farzaneh Tavakkoli Ghazani, Bryan T. Hackfort, Prasanta Dash, Reagan E. Fisher, Benson J. Edagwa, Santhi Gorantla, Keshoer R. Bidasee

Journal Articles: Cellular & Integrative Physiology

The REPRIEVE Trial recently reported high rates of sudden cardiac death (SCD) middle-aged people living with HIV-1 infection (PWH) using the WHO/NIH-recommended two nucleoside reverse transcriptase inhibitors (NRTIs)/one integrase strand inhibitor (INSTI) regimen to manage HIV-1 viremia. To date, clinically relevant animal models to delineate underlying causes for this remain limited. Here, we assessed if HIV-1-infected NOD.Cg-Prkdc^scidIl2rg^tm1Wjl/SzJ humanized mice (Hu-mice) treated with the WHO/NIH-recommended antiretroviral regimen, dolutegravir (DTG, INSTI)/tenofovir disoproxil fumarate (TDF, NRTIs)/emtricitabine (FTC, NRTIs), can recapitulate abnormalities in the ECG and subclinical structural heart disease that serve as harbingers of SCD in middle-aged PWH. …

Activity-Dependent Remodeling Of Muscle Architecture During Distinct Locomotor Behaviors In Caenorhabditis Elegans, Adina Fazyl, Akash Anbu, Sabrina Kollbaum, Andres G. Vidal-Gadea

Faculty Publications – Biological Sciences

Muscle structure is dynamically shaped by mechanical use, yet how distinct locomotor behaviors influence sarcomere organization remains poorly understood. In Caenorhabditis elegans, crawling and swimming constitute discrete gaits that differ in curvature, frequency, and mechanical load, providing a tractable model for studying activity-dependent remodeling. Using confocal imaging of phalloidin-stained body-wall myocytes, we quantified myocyte geometry, sarcomere length, and sarcomere number across anterior, mid-body, and posterior regions in animals reared exclusively under crawling or swimming conditions. Quantification and hypothesis testing used linear mixed models that accounted for repeated myocyte measurements within animals, with interaction terms testing region-specific effects of locomotor …

To Flea Or Not To Flea: Abiotic And Biotic Factors Driving Flea Parasitism On Wild Deer Mice, Parker Todd, Angela Luis, Mike Kinsella

Undergraduate Theses, Professional Papers, and Capstone Artifacts

Deer mice (Peromyscus maniculatus) are an abundant North American rodent and the primary reservoir for Sin Nombre virus (SNV), a hantavirus with a 30-40% case fatality rate in humans. While ectoparasites, such as fleas, are not considered vectors of SNV, their bites may indirectly affect the transmission of SNV by impacting host condition or immune function. These impacts could potentially lead to an increase in host susceptibility and/or an increase in viral shedding, yet there is still little knowledge on what influences flea parasitism on deer mice in western Montana. This study looks to examine how mouse sex, …

The Sub-Lethal Effects Of Trematode Parasites On The Migratory Behavior Of Lesser Scaup (Aythya Affinis), Scott Alan Herman

Graduate Research Theses & Dissertations

The introduction of the invasive freshwater faucet snail (Bithynia tentaculata) and its associated parasites in the Upper Mississippi River and Great Lakes Region provides the opportunity to investigate how anthropogenic stressors impact the life history of lesser scaup (Aythya affinis) using the Mississippi Flyway. To understand the life histories and interactions between lesser scaup and faucet snails we examined historical records, research, and ecology textbooks. Our literature review identified critical knowledge gaps in lesser scaup literature surrounding population dynamics, reproduction, and migration. Specifically, the sub-lethal effects of invasive trematodes on the migratory behavior of lesser scaup in the Upper Mississippi …

Parasite Party: Investigating Ecological Drivers Of Trematode Parasite Prevalence Across The Isles Of Shoals, Aimee D. Bousquet, April Blakeslee, Amy Fowler, David Buck

UNH URC Open (2026 and after)

Parasite Party: Investigating Ecological Drivers of Trematode Parasite Prevalence Across the Isles of Shoals

Insight Into School-Based Tobacco Prevention Education In Arkansas School Districts, Faisal Khan

2026 Research Poster Competition

Insight into School-Based Tobacco Prevention Education in Arkansas School Districts [PD1] Henry Obajaja, Ashley Clawson, Kara Lasater, Victor Kwaku Akakpo, Kolade Olatunde, Luke Larsen, Faisal Khan, Page D Dobbs Characters: 2,500/2,500Select Category: Public Health Study Type: Cross-sectionalPresentation Type – Paper or Poster Funding – select University (College of Education and Health Professions WE CARE Initiative) Significance. Despite national declines in youth tobacco use, Arkansas, a Tobacco Nation state, continues to report disproportionately high rates of tobacco use among adolescents. Prior research found Arkansas school professionals identified student tobacco use as a top health concern; however, it is unclear what tobacco …

Climate Change Effects On Biomass And Greenhouse Gas Emissions Are Ameliorated By Nontoxic Endophytes In Southeastern Usa Transition Zone Tall Fescue Pastures, Rebecca Kay Mcgrail, Jonathan D. Moore, A. Elizabeth Carlisle, Jim A. Nelson, Rebecca L. Mcculley

Plant and Soil Sciences Faculty Publications

Background: The plant–microbe interaction between tall fescue and its endophyte Epichloë coenophiala can affect ecosystem responses to changing rainfall patterns and increasing temperatures. Endophyte-infected (E+) stands often exhibit improved stress tolerance and differing soil greenhouse gas (GHG) emissions compared to endophyte-free (E−) stands. However, it is unknown if mammalian nontoxic endophyte (NTE) strains introduced into some tall fescue cultivars confer differing stress tolerances or reduce soil GHG emissions.

Methods: We quantified the impact of fescue-NTE symbioses in Jesup and Texoma on biomass and GHG emissions in response to increased temperature (+3°C) and altered precipitation (50% lengthened interval between events) using …

Coordinating The Layers: Regulation Of Peptidoglycan Synthesis And Cell Wall Assembly In Mycobacterium Smegmatis By Murj And Pgfa, Karen Emmanuella Samaga-De-Tembiwa

Biology Dissertations

The mycobacterial cell envelope consists of three covalently linked layers whose synthesis must be coordinated to maintain structural integrity during polar growth. While the biosynthetic enzymes for each layer are well characterized, the molecular mechanisms that coordinate synthesis across layers have remained poorly understood. This thesis investigates two essential transmembrane proteins, PgfA and MurJ, that regulate peptidoglycan metabolism in Mycobacterium smegmatis and provide new insight into how mycobacteria synchronize cell wall assembly.

We present evidence that PgfA functions as a bifunctional regulator that links peptidoglycan metabolism to the availability of trehalose monomycolate (TMM), a key mycolic acid precursor. Through epistasis …

Validity And Reliability Of The Wut Hydration System When Assessed In The Afternoon, Peyton Hines

2026 Research Poster Competition

The WUT (weight, urine color, and thirst) Venn diagram is recommended for individuals to self-assess their hydration status. However, current research is limited to comparisons between morning first-void markers and 24-hour markers. PURPOSE: To examine the validity and reliability of afternoon WUT scores in comparison to 24-hour hydration status. METHODS: Fifty participants (25 ± 8y, 72.2 ± 14.9kg) voluntarily participated in this study. Participants collected afternoon spot urine between 2:00 and 4:00 pm and 24-hour urine samples on three out of seven consecutive days. Body mass (BM), urine color (Ucol), urine osmolality (Uosm), urine specific gravity (USG), and thirst perception …

Exploring Experiences Of Contraceptive Counseling & Coercion Among Various Races And Age Groups Of Women Of Reproductive Age., Haylie Horn

2026 Research Poster Competition

Making an informed decision about contraception based on patient-centered contraceptive counseling is a fundamental reproductive right for women. This counseling approach serves as a key indicator of high-quality health care that focuses on and prioritizes patients’ individual needs and preferences regarding contraceptive methods. However, recent studies indicate a growing emphasis on promoting specific contraceptive options – particularly long-acting contraception (LARCs) – without adequately considering patients’ preferences and needs, which has led to growing concerns over contraceptive coercion. Despite concerns, no studies have yet explored the association between certain demographic factors like race, education level, age, socioeconomic status, etc. This study …

Adolescent Development Of Pubertal Hormones, Reward Neurocircuitry, And Externalizing Behaviors And Internalizing Behaviors, Amber Jared

2026 Research Poster Competition

Title: Adolescent development of pubertal hormones, reward neurocircuitry, and externalizing behaviors and internalizing behaviors Authors: Amber Jared & Josiah K. Leong  Background: Adolescence is a period of rapid biological and brain development during which changes in pubertal hormones and neural reward systems may increase vulnerability to emotional and behavioral difficulties. Although prior research has documented widespread brain maturation during adolescence, less is known about how specific subcortical reward pathways develop and how these changes relate to hormones and behavior.  Methods:         Using longitudinal data from the Adolescent Brain Cognitive Development (ABCD) study, this project examines developmental changes in two key brain …

Responses To Influencer’S Vlog On Instagram: Nicotine Pouches And Oral Health, Amrusha Ranjith

2026 Research Poster Competition

Despite claims by ZYN, the leading nicotine pouch brand, that it does not partner with social media influencers, influencers with large followings continue to post content depicting nicotine pouch use. Prior research suggests oral lesions are among the most commonly reported adverse events associated with nicotine pouch use; however, public discussions of these outcomes on social media remain understudied. This study examined public discourse surrounding nicotine pouch use and oral health in response to an Instagram post by a popular influencer. Methods: We collected 1,668 publicly available comments from an Instagram post by Emma Chamberlain (@emmachamberlain) using a social media …

Developing Bioassays For Detection Of Residual Herbicides In Compost, Esther Moore

2026 Research Poster Competition

Developing Bioassays for Detection of Residual Herbicides in Compost, the use of synthetic herbicides has dominated the field of agricultural production for over a century. While synthetic herbicide use has resulted in an undeniable boost in agricultural productivity, risks such as environmental degradation and reduced yield of non-target plant species must be considered. Key among these risks is compost contamination, especially from persistent herbicides. After these herbicides are applied, they are absorbed by growing vegetation, consumed by herbivores, passed through the digestive tract, and reintroduced into soil manure based compost. Even after this process, chemicals in such herbicides can remain …

Disrupted Circadian Rhythms Affect Hallmark Pathologies In Alzheimer’S Disease-Related Mouse Models, Valeria Buzinova

Theses and Dissertations--Molecular and Cellular Biochemistry

Alzheimer’s Disease (AD) is a complex neurodegenerative disease with two hallmark pathologies: extracellular amyloid-b (Ab) and intracellular neurofibrillary tangles (NFTs). Ab is proteolytically processed from amyloid precursor protein (APP) by b-secretase and g-secretase as a monomeric peptide prone to aggregation. Eventually, the aggregate-prone monomers will form dense plaques that are difficult to break down and remove. These plaques begin to deposit into the cortex decades prior to the formation of NFTs and the onset of cognitive decline. NFTs are comprised of hyper-phosphorylated tau. Tau is a protein that serves to promote and stabilize the formation of microtubules. The formation of …

Characterizing The Human Metapneumovirus Matrix Protein And Its Role In Infection, Chase J. Heim

Theses and Dissertations--Molecular and Cellular Biochemistry

Human metapneumovirus (HMPV) causes severe respiratory tract infections in all cohorts, but especially in vulnerable groups such as children, older adults, and the immunocompromised. The matrix (M) protein of HMPV, like the M proteins of other members of the Mononegavirales order, is involved in virus assembly and budding. However, other functions of the HMPV M protein have yet to be elucidated. To investigate these various functions of the M protein, we used a peptide-conjugated phosphorodiamidate morpholino oligomer (PPMO) antisense agent designed to block translation of the M gene to reduce M expression during infection. Treatment with varying concentrations of an …

Social Isolation Predicts Altered Reward Circuit Connectivity And Future Behaviors In Adolescents, Mason Lucas

2026 Research Poster Competition

Adolescence is a period of transition from childhood to adulthood when people explore risky behaviors. Stressors during adolescence can change structural brain connectivity. Previous research has found weaker structural connectivity between reward circuits and future cognitive impairments among children raised in orphanages. Comparative research in mice suggests that social isolation after bullying can damage these connections and induce alcohol seeking. We tested whether social isolation was related to lower connectivity of targeted structural connections in adolescent humans. We analyzed data from the Adolescent Brain Cognitive Development study and found 130 subjects had experienced extreme social isolation. To evaluate the level …

From Chaos To Clockwork: Investigating The Role Of Circadian Genes In Metabolic Development Of 2nd And 3rd Instar Drosophila Larvae, Elliott Ruegsegger

2026 Research Poster Competition

Connecting deficits in circadian rhythm machinery to the severity of other health conditions is a common task that chronobiology, the study of physiological rhythms, undertakes. Disruptions to circadian rhythms and sleep are linked to increased risk of developing multiple different diseases, including Alzheimer’s Disease and obesity. Circadian rhythms are expressed at the molecular level through rhythmic variations in the concentration of specific proteins. While the central clock genes that produce these proteins, such as period and timeless, are evolutionarily conserved across the animal kingdom, not much is known about the consequences of disruptions in circadian rhythm machinery during early development, …

Investigating Changes In White Blood Cell Composition In Wild Hosts In Response To Viral Infection, Anna Bolding

2026 Research Poster Competition

Reservoir hosts play a critical role in the persistence and spillover of zoonotic pathogens. Upon infection, reservoir hosts can shed viral loads sufficient for transmission and spillover often without displaying apparent pathogenic effects. Investigating how their immune systems control infection can provide insights into the factors that facilitate spillover events. Understanding the mechanisms that enable these infection characteristics is crucial for informing public health and conservation strategies. Though reservoir hosts’ immune responses are well-documented in controlled laboratory settings, these studies are not representative of natural populations. The bank vole - Puumala hantavirus (PUUV) system is well suited for investigating such …

Effect Of Organic Vs Inorganic Zinc Sources In Beef Cattle Diets During Gestation On Calf Immune Function And Colostrum Quality, Naija Sharpley

2026 Research Poster Competition

The objective of this study is to determine the effect of zinc supplementation in cattle feed on beef cattle during gestation and the influences of the trace mineral zinc on colostrum and calf immunocompetence measuring immunoglobulin concentrations and body weight. Cow-calf systems rely on the effectiveness and consistency of their nutritional intake. Beef cattle are fed forages and grain alongside specific minerals and supplements to meet nutritional requirements. The effectiveness of these trace minerals added to the diet helps to ensure that the animal gets the most out of its feed and the producer gets the most out of the …

Investigating The Potential Role Of Horse Flies (Diptera: Tabanidae) In The Mechanical Transmission Of Anaplasma Marginale And Theileria Orientalis To Cattle In Northwest Arkansas, Catherine Harrison

2026 Research Poster Competition

The cattle industry in Arkansas plays a significant role in the state’s agricultural economy; however, two emerging infectious diseases pose a threat to cattle health, producer livelihood, and animal welfare. The two diseases, anaplasmosis and theileriosis, are caused by organisms that enter the host’s bloodstream and infect red blood cells, leading to destruction of said cells. The shared symptoms of both diseases are fever, weakness, anemia (low red blood cell count), reduced productivity, weight loss, and possibly death. An important difference between symptoms is that, unlike anaplasmosis, theileriosis can cause abortion in cattle. Both diseases are known to spread through …