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New Records Of The American Bumble Bee, Bombus Pensylvanicus, In Michigan, Sharron Z. Miller, Logan M. Rowe, Lillyanna Widdicombe, Robert P. Jean, Rufus Isaacs Mar 2026

New Records Of The American Bumble Bee, Bombus Pensylvanicus, In Michigan, Sharron Z. Miller, Logan M. Rowe, Lillyanna Widdicombe, Robert P. Jean, Rufus Isaacs

The Great Lakes Entomologist

We report recent detections of the American bumble bee, Bombus pensylvanicus (De Geer) (Hymenoptera: Apidae), in 16 counties of Michigan, USA. This bee species is currently listed as state endangered in Michigan. The current report provides an update on the distribution of B. pensylvanicus in Michigan from collections made between 2020 and 2024, including detections from at least 21 locations in the Lower Peninsula, expanding the known distribution in this state. These samples were from four pollinator survey projects with records from photographs and collections and two online participatory science programs where users uploaded photographs of this species while verified …


Biology, Phenology, And Host Range Of A Seed-Feeding Weevil, Ceutorhynchus Constrictus (Coleoptera: Curculionidae), A Biological Control Agent For Garlic Mustard, Alliaria Petiolata, In North America, Ghislaine Cortat, Hariet L. Hinz, Esther Gerber, Elizabeth J. Katovich, Mary E. Marek-Spartz, Roger L. Becker, Robert S. Bourchier, Danielle Fife Mar 2026

Biology, Phenology, And Host Range Of A Seed-Feeding Weevil, Ceutorhynchus Constrictus (Coleoptera: Curculionidae), A Biological Control Agent For Garlic Mustard, Alliaria Petiolata, In North America, Ghislaine Cortat, Hariet L. Hinz, Esther Gerber, Elizabeth J. Katovich, Mary E. Marek-Spartz, Roger L. Becker, Robert S. Bourchier, Danielle Fife

The Great Lakes Entomologist

Ceutorhynchus constrictus Marsham is a seed-feeding weevil and potential biocontrol agent of the invasive plant garlic mustard, Alliaria petiolata (Bieb.) Cavara & Grande (Brassicaceae), in North America. Ceutorhynchus constrictus is native to Europe, has a single generation per year and eggs are laid into developing seeds within the seedpods of bolting garlic mustard plants. Females use their prolonged rostrum to bore holes through seedpods into the developing seed, deposit a single egg and then cover the opening with secretion. Larvae feed on ripening seeds and progress through three instars before exiting seedpods in late June, to pupate and overwinter in …


Full Issue For Tgle Vol. 58 Nos. 3 & 4 Mar 2026

Full Issue For Tgle Vol. 58 Nos. 3 & 4

The Great Lakes Entomologist

Full issue for TGLE Vol. 58 Nos. 3 & 4


Freshwater Quality For Recreation, Heather Nix, Masha Bokar Mar 2026

Freshwater Quality For Recreation, Heather Nix, Masha Bokar

Forestry and Natural Resources

South Carolina has many water resources that provide tremendous opportunities for people to enjoy water-based recreational activities, such as swimming, boating, and fishing. Participation in these activities produces significant economic benefits and supports many jobs throughout the state. However, at times, water quality may be unsafe for immersion or skin contact due to high levels of pollutants, such as bacteria or cyanotoxins. It is important for people to be aware of potential concerns and understand methods for determining if a waterbody’s current conditions are likely to be safe for primary or secondary recreation.


Impressions Of An Electrolyte Beverage Among Individuals Participating In Collegiate Sports, S. Andrew Cage, Alexander P. Jacobsen, Jessie Gibson, Eric Bobel, Rebecca Peebles, Derek Lege, M.Ed., Cscs Mar 2026

Impressions Of An Electrolyte Beverage Among Individuals Participating In Collegiate Sports, S. Andrew Cage, Alexander P. Jacobsen, Jessie Gibson, Eric Bobel, Rebecca Peebles, Derek Lege, M.Ed., Cscs

Internet Journal of Allied Health Sciences and Practice

Purpose: The purpose of this project was to describe the appeal of an electrolyte hydration beverage for individuals participating in collegiate athletics. A secondary purpose of this project was to describe the acute impact of the examined beverage on the gastrointestinal tract. Methods: A total 100 individuals participating in collegiate athletics were enrolled in this study (age = 21 ± 2 years, Male = 51, Female = 49). Each participant was provided a packet of electrolyte drink mix (EverLyte® sticks, Kent Precision Foods Group, Inc., Muscatine, IA). Participants were instructed to combine the drink mix with a bottle of …


Performance Characteristics Of National Club Baseball Association Athletes Completing In-Season Elastic Resistance Training, Scott K. Harnden, Dawson M. Maxlow, Gena D. Guerin, Merrick A. Lincoln Mar 2026

Performance Characteristics Of National Club Baseball Association Athletes Completing In-Season Elastic Resistance Training, Scott K. Harnden, Dawson M. Maxlow, Gena D. Guerin, Merrick A. Lincoln

Internet Journal of Allied Health Sciences and Practice

Purpose: The purpose of this study was to assess in-season physical performance metrics of National Club Baseball Association Athletes (NCBA) baseball players before and after a 6-week field-based elastic tubing resistance training intervention. Performance metrics included throwing velocity, isometric shoulder rotation strength, dynamic stability, muscular endurance, and range of motion (ROM). Method: A cohort of adult male NCBA athletes (n=13; 20.1±1.1years; 171.4±24.1cm; 77.0±10.5kg; all right hand dominant) enrolled in the 6-week biweekly intervention of seven upper extremity exercises. All exercises were completed with wrist-affixed elastic tubing prior to sport practices. Pre- and post-intervention testing included throwing velocity measured via pocket …


Proteomic Profiling Of Pulmonary Function And Cardiovascular Disease Risk In The Atherosclerosis Risk In Communities Study, Yura Lee, Astrid M Manuel, Ngoc Quynh H Nguyen, Christine Ladd-Acosta, Alanna C Morrison, Kari E North, Eric Boerwinkle, Amil M Shah, Zhongming Zhao, Stephanie J London, Bing Yu Mar 2026

Proteomic Profiling Of Pulmonary Function And Cardiovascular Disease Risk In The Atherosclerosis Risk In Communities Study, Yura Lee, Astrid M Manuel, Ngoc Quynh H Nguyen, Christine Ladd-Acosta, Alanna C Morrison, Kari E North, Eric Boerwinkle, Amil M Shah, Zhongming Zhao, Stephanie J London, Bing Yu

Faculty, Staff and Student Publications

Background: Pulmonary function is linked to cardiovascular disease risk; however, the underlying mechanisms remain unclear. We aimed to identify protein biomarkers associated with pulmonary function and examine their impact on incident chronic obstructive pulmonary disease, coronary heart disease, heart failure, and all-cause mortality.

Methods: Data from White and Black Americans in the Atherosclerosis Risk in Communities study (visit 2: N=11 354, mean age=57 years; visit 5: N=3517, mean age=75 years), a prospective cohort, were analyzed. Linear regression assessed associations between protein levels and pulmonary function measures, including forced expiratory volume in 1 second and forced vital capacity. The impact of …


Muscular Fitness Levels Of U.S. Children And Adolescents, Daniel J. Mcdonough, Yong Gao, Lynda B. Ransdell, Haichun Sun Mar 2026

Muscular Fitness Levels Of U.S. Children And Adolescents, Daniel J. Mcdonough, Yong Gao, Lynda B. Ransdell, Haichun Sun

International Journal of Physical Activity and Health

Purpose: To describe muscular fitness (MF) levels and percentile benchmarks among U.S. children and adolescents aged 6–15 years old across sociodemographic, physiological, and behavioral subgroups. Methods: Data were from the 2012 NHANES National Youth Fitness Survey (NNYFS). Four strength tests consisting of the plank, knee extension, modified pull-up, and handgrip, were analyzed by age, sex, race/ethnicity, income, BMI category, cardiorespiratory fitness (CRF), and physical activity (PA) among 1,234 participants (51% male) using SAS SURVEY procedures. Results: Mean ± SEM scores were 69.6 ± 1.8 s (plank), 56.6 ± 4.2 lb (left) and 59.2 ± 4.3 lb (right) knee extension, 5.5 …


Post-Traumatic Stress Disorder And Risk Of All-Cause And Cause-Specific Mortality: A Nationwide Population And Sibling-Controlled Cohort Study In Taiwan, Chih-Wei Hsu, Yang-Chieh Brian Chen, Liang-Jen Wang, Mu-Hong Chen, Yao-Hsu Yang, Chih-Sung Liang, Edward Chia-Cheng Lai Mar 2026

Post-Traumatic Stress Disorder And Risk Of All-Cause And Cause-Specific Mortality: A Nationwide Population And Sibling-Controlled Cohort Study In Taiwan, Chih-Wei Hsu, Yang-Chieh Brian Chen, Liang-Jen Wang, Mu-Hong Chen, Yao-Hsu Yang, Chih-Sung Liang, Edward Chia-Cheng Lai

Children’s Nutrition Research Center Staff Publications

Aims: Post-traumatic stress disorder (PTSD) may shorten life expectancy, but evidence for Asian populations and cause-specific mortality remains limited. The aim of this study is to investigate the association between PTSD and mortality risk in an Asian population.

Methods: We used Taiwan's National Health Insurance Research Database (2000-2022) to assemble a cohort of 28,777 individuals with incident PTSD and 115,108 age- and sex-matched unexposed individuals, plus a sibling cohort of 13,305 affected patients and 22,030 unaffected siblings. Cox models estimated adjusted hazard ratios (AHRs) for all-cause, unnatural-cause (suicide and accidents) and natural-cause mortality, with progressive adjustment for sociodemographic factors, comorbidity …


Influence Of Body Composition On The Efficacy Of Nivolumab Plus Ipilimumab For Metastatic Clear Cell Renal Cell Carcinoma, Kabir Grewal, Maria Julia Moura Nascimento Santos, Pankaj Kumar Chauhan, Kai Yu, Nizar M Tannir, Sagar S Mukhida, Neha Venkatesh, Amishi Y Shah, Amado J Zurita, Andrew C Johns, Matthew T Campbell, Sangeeta Goswami, Jianjun Gao, Eric Jonasch, Jennifer L Mcquade, Omar Alhalabi, Pavlos Msaouel, Andrew W Hahn Mar 2026

Influence Of Body Composition On The Efficacy Of Nivolumab Plus Ipilimumab For Metastatic Clear Cell Renal Cell Carcinoma, Kabir Grewal, Maria Julia Moura Nascimento Santos, Pankaj Kumar Chauhan, Kai Yu, Nizar M Tannir, Sagar S Mukhida, Neha Venkatesh, Amishi Y Shah, Amado J Zurita, Andrew C Johns, Matthew T Campbell, Sangeeta Goswami, Jianjun Gao, Eric Jonasch, Jennifer L Mcquade, Omar Alhalabi, Pavlos Msaouel, Andrew W Hahn

Faculty, Staff and Student Publications

Background: Immune checkpoint inhibitor therapy (ICI) with nivolumab+ipilimumab is a first-line (1L) standard for metastatic clear cell renal cell carcinoma (ccRCC), yet outcomes remain heterogeneous. Increasing evidence suggests that host factors influence the tumor microenvironment and response to ICI. Although higher body mass index (BMI) has been associated with improved outcomes in several malignancies, BMI is an imprecise surrogate for underlying adipose and muscle compartments. We evaluated the association between body composition and outcomes with 1L nivolumab+ipilimumab in metastatic ccRCC.

Methods: We retrospectively analyzed patients with mccRCC treated with 1L nivolumab+ipilimumab at MD Anderson Cancer Center between June 2015 and …


Circulating Ketone Bodies And Incident Cardiovascular Outcomes And Mortality: Insights From The Uk Biobank, Parag Anilkumar Chevli, Saeid Mirzai, Richard Kazibwe, Jeff Kingsley, Alexis C Wood, Joseph Yeboah, Leandro Slipczuk, Anurag Mehta, Harpreet S Bhatia, Ambarish Pandey, Michael D Shapiro Mar 2026

Circulating Ketone Bodies And Incident Cardiovascular Outcomes And Mortality: Insights From The Uk Biobank, Parag Anilkumar Chevli, Saeid Mirzai, Richard Kazibwe, Jeff Kingsley, Alexis C Wood, Joseph Yeboah, Leandro Slipczuk, Anurag Mehta, Harpreet S Bhatia, Ambarish Pandey, Michael D Shapiro

Children’s Nutrition Research Center Staff Publications

Background: Ketone bodies (KB) are endogenous energy sources synthesized by the liver in response to metabolic stress. Their associations with atherosclerotic cardiovascular disease (ASCVD), heart failure (HF), and mortality and their potential beneficial or harmful effects have yet to be determined. This study aimed to examine the association between KB and incident cardiovascular outcomes and mortality in a large general population cohort free from ASCVD and HF at baseline.

Methods: This analysis included 90 987 participants (mean age 56.4 ± 8.1 years; 54.7% women) from the UK Biobank without prevalent ASCVD or HF. KB were measured by nuclear magnetic resonance …


Comparative Antibacterial Efficacy Of Povidone-Iodine, Citric Acid, And Starch: A Study Of Combined Activity And Interference Effects Against Clinically Relevant Bacteria, Falah Hasan Obayes Al-Khikani, Mustafa Mutar Trrad, Ali Abedulameer Alhusayni Mar 2026

Comparative Antibacterial Efficacy Of Povidone-Iodine, Citric Acid, And Starch: A Study Of Combined Activity And Interference Effects Against Clinically Relevant Bacteria, Falah Hasan Obayes Al-Khikani, Mustafa Mutar Trrad, Ali Abedulameer Alhusayni

AUIQ Complementary Biological System

Povidone-iodine and citric acid are widely used antimicrobial agents. However, data on their comparative efficacy and the functional outcomes of their combination, particularly regarding the influence of common excipients like starch, is limited. Understanding these interactions is crucial for optimizing antiseptic formulations. This study aimed to evaluate and compare the antibacterial activity of povidone-iodine, citric acid (5% and 20%), and starch (5% and 20%), both individually and in combination, against clinical isolates of Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa. The antibacterial activity of the agents was assessed using an agar well diffusion assay. Mean inhibition zone …


Self-Aware Quantum-Inspired Routing Framework For 6g And Quantum Networks, Haitham M. Abdelghany, Mohamed M. Ashour Mar 2026

Self-Aware Quantum-Inspired Routing Framework For 6g And Quantum Networks, Haitham M. Abdelghany, Mohamed M. Ashour

Mansoura Engineering Journal

This paper introduces a quantum-hybrid-aware routing framework that incorporates the concepts of quantum computing with meta-cognitive learning to improve adaptability, reliability, and awareness in dynamic quantum networks. The proposed system accommodates a new IoT, edge computing and 6G system, where routing schemes should be flexible and robust and have cross-topology functionality. Conventional methods of quantum reinforcement learning can be characterized by a trade-off between exploration and decision stability. To cope with this, the proposed self-aware hybrid architecture is a combination of quantum-enhanced learning and a meta-cognitive awareness layer to allow autonomous agents to monitor performance and adjust routing strategies on …


Biodiversity Between The Vines: Common, Rare, And Weedy Plants In Willamette Valley Vinyards, Nora Dunkirk, Gabriel Campbell Mar 2026

Biodiversity Between The Vines: Common, Rare, And Weedy Plants In Willamette Valley Vinyards, Nora Dunkirk, Gabriel Campbell

Institute for Natural Resources Publications

Vineyards in the Willamette valley are more than rows of grapes—they are living landscapes. Between the vines is a diverse community of over 1,500 plant species that support soil health, pollinators and beneficial insects, birds and other wildlife, and contribute meaningfully to the resiliency and productivity of vineyards. Among the natives are also introduced and exotic plants that compete with the native species. Every plant tells a story—together, they form a living vineyard. Here we present common, rare, and exotic weedy species of Willamette Valley vineyards along with identification tips about each species. Presented at the 2026 LIVE conference (livecertified.org).


Jackfruit Peel Valorization Through An Integrated Biorefinery Approach, Rohil Kumar K Mr Mar 2026

Jackfruit Peel Valorization Through An Integrated Biorefinery Approach, Rohil Kumar K Mr

Theses and Dissertations

Jackfruit (Artocarpus heterophyllus) peel (JFP), an abundantly available lignocellulosic biomass, remains largely underutilized despite being rich in cellulose, hemicellulose, lignin, and pectin. In India, approximately 13,460 hectares are under jackfruit cultivation, with Panruti in Tamil Nadu as a major production zone. The discarded peel often contributes to environmental pollution and greenhouse gas emissions. The present study emphasizes sustainable valorization of JFP through an integrated biorefinery framework for generating value-added bioproducts.

Major biopolymers, cellulose, hemicellulose, lignin, and pectin were extracted and fractionated, followed by detailed physicochemical characterization using FTIR, NMR, XRD, SEM, TGA, DSC, GPC, and BET analyses. Pectin extraction with …


Ectopic B Lymphocyte Follicles Exacerbate Ischemic Brain Damage Via Mif-Cd74/Cxcr4 And Interferon Signaling, Sheng Yang, Hang Zhang, Lu-Lu Xu, Luo-Qi Zhou, Yun-Hui Chu, Lian Chen, Xiao-Wei Pang, Lu-Yang Zhang, Li-Fang Zhu, Ming-Hao Dong, Ke Shang, Jun Xiao, Long-Jun Wu, Wei Wang, Dai-Shi Tian, Chuan Qin Mar 2026

Ectopic B Lymphocyte Follicles Exacerbate Ischemic Brain Damage Via Mif-Cd74/Cxcr4 And Interferon Signaling, Sheng Yang, Hang Zhang, Lu-Lu Xu, Luo-Qi Zhou, Yun-Hui Chu, Lian Chen, Xiao-Wei Pang, Lu-Yang Zhang, Li-Fang Zhu, Ming-Hao Dong, Ke Shang, Jun Xiao, Long-Jun Wu, Wei Wang, Dai-Shi Tian, Chuan Qin

Faculty, Staff and Student Publications

Neuroinflammation, encompassing both innate and adaptive immune responses, plays a crucial role in ischemic stroke. Although B lymphocytes are central to adaptive immunity, their contributions to ischemic stroke remain poorly understood. Here, we demonstrated that B lymphocytes accumulate in ischemic lesions, forming germinal center-like structures at the later stage after stroke, which mainly depended on in situ proliferation. This accumulation correlated with worsened neuroinflammation and ischemic injury, whereas B cell depletion reduced chronic brain damage during stroke. Mechanistically, microglia recruited B cells into ischemic lesions through MIF-CD74/CXCR4 signaling during the early phase of stroke, while IFN-related pathways in B cells …


Dna Methylation Is Associated With Von Willebrand Factor And Coagulation Factor Viii Plasma Levels: The Atherosclerosis Risk In Communities Study, Julie Hahn, Jan Bressler, Myriam Fornage, Eric Boerwinkle, Nicholas L Smith, Alanna C Morrison, Paul S De Vries Mar 2026

Dna Methylation Is Associated With Von Willebrand Factor And Coagulation Factor Viii Plasma Levels: The Atherosclerosis Risk In Communities Study, Julie Hahn, Jan Bressler, Myriam Fornage, Eric Boerwinkle, Nicholas L Smith, Alanna C Morrison, Paul S De Vries

Faculty, Staff and Student Publications

Background: Limited information is available on how DNA methylation of cytosine-phosphate-guanine (CpG) sites across the genome regulate circulating von Willebrand Factor (VWF) and factor VIII (FVIII) levels.

Methods: We performed an epigenome-wide association study to examine the association of leukocyte DNA methylation levels at 483,735 CpG sites with VWF antigen plasma levels and FVIII activity in 2,597 Black and 1,011 White participants from the Atherosclerosis Risk in Communities (ARIC) study. VWF antigen levels and FVIII activity were measured at the baseline exam, while DNA methylation was measured with the Infinium HumanMethylation450 BeadChip array at visit 2 or 3. Discovery analysis …


Poly(Adp-Ribose) Glycohydrolase Enforces P21 Degradation Via Deparylation To Promote Gastric Cancer Progression, Yangchan Hu, Qimei Bao, Yixing Huang, Yan Wang, Xin Zhao, Junjun Nan, Yuxin Meng, Mingcong Deng, Yuancong Li, Zirui Zhuang, Hanyi He, Dan Zu, Yuke Zhong, Chunkai Zhang, Bing Wang, Ran Li, Yanhua He, Qihan Wang, Min Liu, John A Tainer, Yin Shi, Xiangdong Cheng, Ji Jing, Zu Ye Mar 2026

Poly(Adp-Ribose) Glycohydrolase Enforces P21 Degradation Via Deparylation To Promote Gastric Cancer Progression, Yangchan Hu, Qimei Bao, Yixing Huang, Yan Wang, Xin Zhao, Junjun Nan, Yuxin Meng, Mingcong Deng, Yuancong Li, Zirui Zhuang, Hanyi He, Dan Zu, Yuke Zhong, Chunkai Zhang, Bing Wang, Ran Li, Yanhua He, Qihan Wang, Min Liu, John A Tainer, Yin Shi, Xiangdong Cheng, Ji Jing, Zu Ye

Faculty, Staff and Student Publications

Dysregulation of cell cycle checkpoints is a cancer hallmark, with ubiquitination-controlled protein stability playing a pivotal role. Although p21, a key cyclin-dependent kinase inhibitor, is tightly regulated by ubiquitin-mediated degradation, the key upstream modulators of its ubiquitination remain incompletely defined. Here, we identify poly(ADP-ribose) glycohydrolase (PARG) as a regulator of p21 stability in gastric cancer (GC) cells. We show that PARG expression is markedly upregulated in GC tissues and correlates with poor patient prognosis. Functional assays revealed that genetic depletion of PARG triggers G2/M phase arrest and impairs GC cell proliferation. Mechanistically, we demonstrate that PARG loss enhances p21 PARylation, …


Mechanometabolism Instructs Hematopoietic Stem Cell Specification, Paulina D Horton, Alina Syed, Michelle Winkler, Abishek B Vaidya, Michael Rariden, Neha Arora, Yong Zhou, Michihiro Kobayashi, Momoko Yoshimoto, Hyun Jung Lee, Hyun-Eui Kim, John P Hagan, Catherine Denicourt, Travis I Moore, Pamela L Wenzel Mar 2026

Mechanometabolism Instructs Hematopoietic Stem Cell Specification, Paulina D Horton, Alina Syed, Michelle Winkler, Abishek B Vaidya, Michael Rariden, Neha Arora, Yong Zhou, Michihiro Kobayashi, Momoko Yoshimoto, Hyun Jung Lee, Hyun-Eui Kim, John P Hagan, Catherine Denicourt, Travis I Moore, Pamela L Wenzel

Faculty, Staff and Student Publications

Mechanical force generated by blood flow stimulates emergence of the first hematopoietic stem cells (HSCs) that populate the blood system. Force drives the transition of HSC precursors from an endothelial to hematopoietic identity, yet the molecular regulation of this fate switch remains poorly understood. We report that shear stress triggers adaptation in mitochondrial composition, ultrastructure, and function, which are essential for hematopoietic fate and engraftment potential. Shear stress remodels mitochondria in hemogenic endothelium by promoting mitochondrial gene transcription and protein synthesis. Laminar flow selectively initiates translation of 5' terminal polypyrimidine (5'TOP) motif-containing transcripts, which commonly encode ribosome and translation machinery. …


Sustainable Aviation Fuel (Saf) From Used Cooking Oil (Uco) In Egypt: Opportunities And Challenges., Lamiaa Abdallah Mar 2026

Sustainable Aviation Fuel (Saf) From Used Cooking Oil (Uco) In Egypt: Opportunities And Challenges., Lamiaa Abdallah

Mansoura Engineering Journal

Global aviation sector contributes nearly 2.5% of global CO2 emissions. Aviation is hard-to-decarbonize sector due to the high energy densities required for aircraft. Commercial aviation is fueled by kerosene-based jet fuel. Alternatives for this carbonbased fuel include electric batteries, hydrogen fuel, and SAF. Electric batteries have very low energy densities. Hydrogen would require a complete change of the aviation system, including fuel & airport infrastructure. SAF is the only viable option in the short to medium term. SAF is produced from sustainable feed-stocks (like agricultural oils), with no embodied carbon. Existing airplanes can use traditional fuel blended with up to …


The Need For Developing Psychologically Informed Physical Therapy Education, Dustin Cox Mar 2026

The Need For Developing Psychologically Informed Physical Therapy Education, Dustin Cox

Journal of Applied Disciplines

Chronic pain presents a multifaceted challenge for healthcare providers, often impacting patients' physical, emotional, and psychological well-being. Research indicates that individuals with chronic pain process pain through emotional and reward pathways in the brain, underscoring the need for integrative treatment approaches. Evidence supports the effectiveness of combining psychological interventions with physical rehabilitation to improve outcomes. Acceptance and Commitment Therapy (ACT), a mindfulness-based behavioral therapy, has shown promise in addressing the psychological dimensions of chronic pain. However, physical therapists often lack formal training in ACT. This study protocol was designed to explore effective methods for educating physical therapists in ACT principles …


Plaster Creek Watershed Management Plan: Chloride Addendum, Plaster Creek Stewards Mar 2026

Plaster Creek Watershed Management Plan: Chloride Addendum, Plaster Creek Stewards

Watershed Reports

This addendum complements the 2008 Plaster Creek Watershed Management Plan (WMP), which tells the full story of the Plaster Creek Watershed’s current condition, impairments, and need for restoration. This addendum focuses on chloride, an emerging pollutant of concern in Michigan that was not addressed in Plaster Creek’s 2008 WMP. This addendum meets the nine elements required by the United States Environmental Protection Agency (EPA) for a watershed management plan to be officially approved; as such, its content and layout are intended for a technical audience.


Circuit And Synaptic Mechanisms Of Methamphetamine Induced Cognitive Deficits During Abstinence: Roles Of The Perirhinal-Prefrontal Pathway And The Nucleus Reuniens, Sarah Goldsmith Mar 2026

Circuit And Synaptic Mechanisms Of Methamphetamine Induced Cognitive Deficits During Abstinence: Roles Of The Perirhinal-Prefrontal Pathway And The Nucleus Reuniens, Sarah Goldsmith

MUSC Theses and Dissertations

Cognitive deficits during abstinence are a hallmark of methamphetamine (meth) use and indicative of negative treatment outcomes. In rats, both long access meth self-administration and meth binge produce recognition memory deficits due to drug-induced plasticity within the perirhinal cortex (PRH). PRH projections are numerous and include the medial prefrontal cortex (mPFC) and the Nucleus Reuniens (NRe). In the first study, the role of the PRH-mPFC reciprocal circuit in novel object recognition memory was investigated by infusing an rgAAV encoding GFP-tagged Cre recombinase into the PRH or the mPFC. Following surgery, rats explored objects. During exploration, PRH neurons receiving input from …


Differential Effects Of Neighborhood Ambient Pm2.5 Exposure And Social Vulnerability On Cancer-Related Systemic Inflammation By Race In A Large Health Care System Population From 2000 To 2020, Benjamin A. Rybicki, Zihan Lin, Amber L. Pearson Mar 2026

Differential Effects Of Neighborhood Ambient Pm2.5 Exposure And Social Vulnerability On Cancer-Related Systemic Inflammation By Race In A Large Health Care System Population From 2000 To 2020, Benjamin A. Rybicki, Zihan Lin, Amber L. Pearson

Biological, Geological, and Environmental Faculty Publications

BackgroundThe environment can impact cancer risk both directly, such as through the air we breathe, and indirectly, through the neighborhoods we live in. These risk factors often work in concert but can have disparate effects.MethodsTo understand how air pollution, as measured by ambient particulate matter 2.5 (PM2.5) levels and neighborhood disadvantage based on a geographically assigned social vulnerability index (SVI), may act together to impact cancer risk, we used 2000-2020 statewide cohort data from a large health system based in metropolitan Detroit, MI, USA (n = 245,438). Systemic inflammation was used as a surrogate indicator of cancer risk among study …


A Bacillus Pumilus Isolate With Promising Antimycobacterial Properties, Cody M. Pfaff Mar 2026

A Bacillus Pumilus Isolate With Promising Antimycobacterial Properties, Cody M. Pfaff

SACAD: Scholarly Activities

The emergence of multidrug-resistant bacterial pathogens, particularly Mycobacterium tuberculosis, highlights the urgent need for new antimicrobial agents. Tuberculosis remains one of the world’s deadliest infectious diseases, claiming over a million lives annually and posing increasing challenges due to the thick, lipid-rich, acid-fast cell wall of Mycobacterium species that renders them naturally resistant to many antibiotics. In this study, a soil sample collected from the Campus of Fort Hays State University yielded a bacterial isolate exhibiting strong antimicrobial activity. Initial screening against Escherichia coli MM294 showed a 10 mm inhibition zone, and subsequent testing identified the isolate as Bacillus pumilus …


In Vitro Pharmacological Evaluation Of Novel Cmpi Derivatives As Selective Positive Allosteric Modulators Of The Alpha4 Beta2 Nicotinic Acetylcholine Receptor, Josue Gaona, Nataly Sanchez, Wilder Felix, Nathalia Menegasso, Brisa Cea, Ganesh Thakur, Ayman K. Hamouda Mar 2026

In Vitro Pharmacological Evaluation Of Novel Cmpi Derivatives As Selective Positive Allosteric Modulators Of The Alpha4 Beta2 Nicotinic Acetylcholine Receptor, Josue Gaona, Nataly Sanchez, Wilder Felix, Nathalia Menegasso, Brisa Cea, Ganesh Thakur, Ayman K. Hamouda

School of Medicine Student Publications and Presentations

Nicotinic acetylcholine receptors (nAChRs) contribute to the pathogenesis of neurodegenerative diseases such as Parkinson’s disease (PD), where degeneration of dopaminergic and cholinergic neurons disrupts neurotransmission. The (α4)₃(β2)₂ nAChR subtype is expressed on affected neuronal populations and represents a promising therapeutic target. Positive allosteric modulators (PAMs) may enhance receptor function while preserving endogenous signaling. We evaluated chemical derivatives of CMPI [3-(2-chlorophenyl)-5-(5-methyl-1-(piperidin-4-yl)-1H-pyrazol-4-yl)isoxazol] as selective PAMs of (α4)₃(β2)₂ nAChRs. Two-electrode voltage-clamp recordings were performed in Xenopus laevis oocytes expressing defined receptor stoichiometries to assess potentiation and generate dose–response curves. Cytotoxicity was assessed in HEK cells using the MTT assay. Substitutions at the pyrazole …


The Emerging And Evolving Evidence Supporting Creatine As An Ergogenic Aid: History And Applications, Chad Kerksick, Drew Gonzalez, Jeffrey Stout, Scott Forbes, Darren Candow, Tim Ziegenfuss, Ronald Marshall, René Schwesig, Richard Kreider Mar 2026

The Emerging And Evolving Evidence Supporting Creatine As An Ergogenic Aid: History And Applications, Chad Kerksick, Drew Gonzalez, Jeffrey Stout, Scott Forbes, Darren Candow, Tim Ziegenfuss, Ronald Marshall, René Schwesig, Richard Kreider

Faculty Scholarship

Background

Creatine is one of the most extensively studied ergogenic aids, with over three decades of research supporting its role in exercise performance, recovery, and health.

Methods

This narrative review summarizes the historical development of creatine supplementation and evaluates evidence regarding its mechanisms, efficacy across active, athletic populations (e.g. strength, endurance, team-sport), and tactical (e.g. military, law enforcement) populations, and its safety profile.

Results

The evidence suggests that creatine enhances phosphocreatine resynthesis and cellular energy availability, resulting in consistent improvements in high-intensity exercise performance, training adaptations, lean body mass, strength, and power. Additional findings indicate that creatine may attenuate exercise-induced …


Improvements To Fisheries Compensation Processes And Valuation Methodologies In Western Australia, Department Of Primary Industries And Regional Development, Western Australia Mar 2026

Improvements To Fisheries Compensation Processes And Valuation Methodologies In Western Australia, Department Of Primary Industries And Regional Development, Western Australia

Fisheries Published Reports

This report has been prepared by the Compensation Working Group (WG) to provide advice to the Minister for Fisheries on improving Western Australia’s (WA) fisheries compensation processes under two key legislative frameworks:

This work has been undertaken as a precursor to the larger scale adjustment and compensation processes that will be required as part of the implementation of several marine parks throughout the Kimberley and South Coast of WA.


Women’S Roles In Philippine Agriculture In The Context Of Climate Change: A Meta-Synthesis Using The Gender Analysis Framework, Gemnmalyn M. Trespalacio, Nico Jayson C. Anastacio, Samantha Geraldine G. De Los Santos Mar 2026

Women’S Roles In Philippine Agriculture In The Context Of Climate Change: A Meta-Synthesis Using The Gender Analysis Framework, Gemnmalyn M. Trespalacio, Nico Jayson C. Anastacio, Samantha Geraldine G. De Los Santos

The Philippine Agricultural Scientist

This paper highlights the critical role of women, including their contribution to adapting to the effects of climate change on the Philippine agriculture sector. It provides an overview of women’s roles in agriculture in the context of climate change through the lens of the Gender Analysis Framework (GAF). A total of 1,823 relevant articles were collected from ScienceDirect, adopting the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. After 2 levels of screening process, 17 articles were synthesized guided by the domains of GAF: (1) access to assets; (2) practices and participation; (3) beliefs and perception; and (4) …


Carotenoid Profiles Of Momordica Cochinchinensis (Lour.) Spreng. Aril And Leaves As Potential Dietary Caroteniod Sources [Research Note], Francis A. Aguilar, Antonio C. Laurena, Nerrisa K. Torreta, Vida Faith R. Galvez, Evelyn B. Rodriguez, Lourdes B. Cardenas Mar 2026

Carotenoid Profiles Of Momordica Cochinchinensis (Lour.) Spreng. Aril And Leaves As Potential Dietary Caroteniod Sources [Research Note], Francis A. Aguilar, Antonio C. Laurena, Nerrisa K. Torreta, Vida Faith R. Galvez, Evelyn B. Rodriguez, Lourdes B. Cardenas

The Philippine Agricultural Scientist

Momordica cochinchinensis (Lour.) Spreng. or sweet gourd is a perennial, dioecious vine known to possess remarkable carotenogenic capacity. To explore its potential as a dietary carotenoid source, this study evaluated the carotenoids of aril from ripe fruits and of leaves of an accession from Laoag, Ilocos Norte, Philippines, through open-column chromatography. Data reveal that the optimal fruit ripeness for aril carotenoid quantification, determined by fruit skin redness (CIELAB a* value), was achieved 6 to 7 wk after pollination, at which time the aril was found to contain lycopene at 1,260.64 ± 56.17 μg g−1 fresh weight (FW) and β-carotene …