Digital Commons Network^™

Effects Of Gibberellic Acid (Ga3) On Growth, Height, And Structural Strength In Mutant Setaria Viridis, Gracie Jones, Emma Lewis, Robert Larsen, Alejandro Molina

2026 Student Academic Showcase

Gibberellin (GA3) is a plant hormone that promotes stem elongation and overall plant growth. It increases cell elongation, which results in taller plants. However, increased growth may come at the cost of structural strength. Some mutant plants respond differently to gibberellin depending on whether they are sensitive or insensitive to the hormone. Sensitive mutants lack the ability to produce gibberellin but respond when it is applied, while insensitive mutants do not respond due to defects in hormone signaling. This experiment examines how GA3 affects plant height, panicle development, and structural stability in mutant Setariaviridis.

Neuromuscular Function And Balance In Young Adults: Feasibility And Reliability Of Strength And Conditioning Assessments, Riley Fritzsche, Nicole Waldo Johnson, Jessica M. Moon

2026 Student Academic Showcase

Neuromuscular assessments are widely used in exercise science however; the reliability of comprehensive functional testing batteries in healthy young adults remains unclear. Since sex and hormone status may influence performance, this study proposes that neuromuscular outcomes will differ across males, naturally cycling females, and hormonal contraceptive users. This pilot study will evaluate the feasibility and test-retest reliability of a neuromuscular assessment battery in adults aged 18–35 using a repeated-measures design. Participants will complete two identical testing sessions separated by 5–10 days. Assessments will include balance on force plates, handgrip strength, a 5-repetition chair-rise, and the 3-meter Timed Up-and-Go, alongside neuromuscular …

Environmental Stability Drives Development In Drosophila Melanogaste, Nestor Omar Rivera Guevera

2026 Student Academic Showcase

The development of Drosophila melanogaster is highly sensitive to environmental conditions, particularly temperature, which has been shown to influence both developmental rate and lifespan. Previous studies report that higher temperatures accelerate development but may reduce adult longevity, while field observations in related Drosophila species indicate that stable environmental conditions support greater population success compared to fluctuating ones. Building on this, the present study examined the combined effects of temperature and humidity on fruit fly development. Groups of 10 female flies were placed in culture tubes containing standard medium, with three replicates per treatment. After 48 hours of egg-laying, adults were …

The Past, Present And Future Of The Dietary Guidelines Of America And The Impact On Community Nutrition, Jordyn Dearth

2026 Student Academic Showcase

The most recent addition of the Dietary Guidelines of America have been released to the public, and has caused many questions to the community. The guidelines serve not only as a resource for the general public and a resource for local and national policy regarding nutrition. Because community nutrition is directly shaped by these recommendations, exploring its past implementations, present implications and possible future actions can help in understanding how these guidelines influence public health at local and national levels. This project aims to explain the impact of the past Dietary Guidelines, show the newest Dietary Guidelines, and predict how …

Effects Of Spatially Targeted Fertilizer Strategies On Canopy Growth Across Contrasting Tart Cherry Orchard Sites, Kurt Wedegaertner, Brent Black, Matt Yost, Grant Cardon

Plants, Soils and Climate Student Research

Variable-rate fertilization is increasingly promoted in perennial orchard systems, but its effectiveness remains difficult to predict because tree responses are often inconsistent and strongly conditioned by site-specific constraints. To address this, we evaluated soil-based and vigor-based zoning frameworks across four commercial tart cherry (Prunus cerasus) orchards representing contrasting soil conditions, canopy structures, and management histories. Within each orchard, management zones were defined using either soil apparent electrical conductivity (ECa) or satellite-derived canopy vigor. Fertilization strategies were implemented by varying fertilizer application timing among zones using split-application approaches while maintaining a constant total fertilizer rate. Tree-level canopy structure was …

Mitochondrial Dna Replication Is Regulated By Endoplasmic Reticulum-Mitochondrial Contact Sites, The Mitochondrial Calcium Uniporter, And Manganese, Amaia Lopez De Arbina, Angelica Zamudio-Ochoa, Mikel Muñoz-Oreja, Diego Perez-Rodriguez, Laura Mosqueira-Martín, Rebecca Lasalandra, Marina Villar-Fernandez, Uxoa Fernandez-Pelayo, Laura Rodriguez-Gomez, Seungtae Lee, Francisco Gil-Bea, Nerea Osinalde, Ainara Vallejo-Illaramendi, Dmitry Temiakov, Antonella Spinazzola, Ian Holt

Department of Biochemistry and Molecular Biology Faculty Papers

Mitochondrial DNA replication occurs at contact sites between the endoplasmic reticulum (ER) and mitochondria (ERMCS). Beyond the known role of the tubular ER protein RTN4, the factors regulating this process are poorly defined. Here, we show that repressing the ER protein ERLIN2 in human fibroblasts depletes ER-mitochondrial contact sites and inhibits mitochondrial DNA replication, as does silencing RTN4 or the ER-mitochondrial tether GRP75. GRP75 or RTN4 scarcity also decreases the level of the mitochondrial calcium uniporter (MCU), whose inhibition blocks mitochondrial DNA synthesis. Because ERMCS depletion did not diminish mitochondrial calcium, and MCU complex can transport manganese, we tested whether …

Creating Sustainable School And Home Gardens: Gardening With Native Plants, Kathy Cabe Trundle, Lawrence Krissek

All Current Publications

Native plants form the foundation for healthy local and regional ecosystems. By adding native plants to your gardening and landscape plans, you will contribute to nature’s best hope for the soil health, habitat resilience, and biodiversity we need for a brighter, more sustainable future.

Identification Of Lipid Quantitative Trait Loci Linked With Cardiometabolic Disease In Asian Indians And Europeans: A Genome-Wide Association Study And Mendelian Randomization, Madhusmita Rout, Christopher E. Aston, Ravindranath Duggirala, Harald H. H. Goring, Oliver Fiehn, Dharambir K. Sanghera

School of Medicine Publications

Background: Genetic mechanisms that predispose people to type 2 diabetes (T2D) and cardiovascular disease (CVD) remain poorly understood, partly because of a lack of sufficient data on non-European ethnic groups. Extending these evaluations to diverse cohorts is essential for gaining insights into the molecular pathways involved in disease development among human populations. In this study, we aimed to evaluate the genetic connection between the human lipidome and cardiometabolic disorders. We conducted a metabolite genome-wide association study (mGWAS) in a Punjabi population from India, along with multi-layer replication studies using the UK Biobank and other independent European and non-European cohorts.

Methods …

Advancing Early Detection Of Diabetic Retinopathy At Clínica Esperanza/Hope Clinic, Rachel Burke

Biology Student Scholarship

No abstract provided.

Image Analysis Of Pupal Sex Ratio In Honey Bee Hives, Anna R. Tattelman, Grace E. O’Brien

Biology Student Scholarship

No abstract provided.

The Role Of The Microbiome In Gynecological Cancers: Implications For Diagnosis And Treatment, Precious Adeoye Oyedokun, Bobola Timothy Oyeleke, Onigbinde Oluwanisola Akanji, Abraham Ololade Oyelaran, Kehinde Philip O, Grace Bosede Akanbi, Philip Olagbede Oyedokun, Marvelous Dasola Oyedokun, Chikezie Chinelo Naomi, Oyeniran Oluwatosin Imoleayo, Roland Eghoghosoa Akhigbe

Michigan Tech Publications

Gynecological malignancies such as cancer of the cervix, ovary, endometrium, vulva, and vagina pose a severe global health burden. Although conventionally attributed to genetic mutation, hormonal imbalance, and chronic viral infection, including high-risk human papillomavirus, recent evidence suggests that the human microbiome plays a central role in their pathogenesis and development. This review summarizes existing evidence that microbial dysbiosis, specifically the depletion of beneficial Lactobacillus species and overrepresentation of anaerobic organisms such as Fusobacterium, Atopobium, and Sneathia, is implicated in carcinogenesis pathways. These include chronic inflammation, immune modulation, loss of epithelial barrier integrity, microbial metabolite toxicity, and estrogen metabolism by …

Impact Of Pvc Microplastics On The Growth Of Raphanus Sativus, Olivia Fawkes, Alissia D. Fulton, Darlene Panvini

SPARK Symposium Presentations

Microplastics have emerged as a growing concern due to their increasing prevalence in terrestrial ecosystems. Understanding how microplastics affect plant growth is crucial for the agricultural industry, as crop productivity and soil quality have a direct impact on food security and farm sustainability. This study examined the impact of polyvinyl chloride (PVC) microplastics on the germination and growth rate of Raphanus sativus. Seeds were grown for six weeks in a controlled growth chamber in petri plates and soil pots containing varying concentrations of PVC microplastics (0, 25, 50, 75, 100 mg/L), including untreated PVC and PVC artificially weathered through …

Exercise As A Non-Pharmacological Intervention For The Prevention And Delay Of Alzheimer’S Disease And Dementia, Eden Culver

Honors Theses

Alzheimer’s disease (AD) and related dementias are rapidly increasing public health concerns due to aging populations and rising life expectancy. Alzheimer’s disease is characterized by progressive neurodegeneration associated with amyloid-β plaques, tau neurofibrillary tangles, neuroinflammation, oxidative stress, and neuronal loss, leading to impairments in memory, cognition, and daily functioning. Because there is currently no cure for Alzheimer’s disease, identifying effective non-pharmacological prevention strategies is essential. This paper examines the role of physical exercise as a preventive and protective intervention for delaying the onset and progression of Alzheimer’s disease and dementia. Current research demonstrates that exercise supports brain health through several …

Scientific Research In Cuba: A General Analysis With A Special Focus On Energy, Agriculture And Technology, Henri Dou, Pierre Fournie

International Journal of Islands Research

An analysis of science in Cuba is carried out using data from the OpenAlex database. Examples are developed: agriculture, rice, technology in relation to the current situation: national food supply, energy and medicine. The predominance of research in biology and medicine and the low commitment in the fields of agriculture, energy, medicinal plants and technology are highlighted. Various development schemes are proposed. The conclusion is that research must be directed towards strategic areas: food and energy, must be less dispersed and that technology must be better taken into account. Three proposals are made: the development of a chemical analysis platform …

​Functional Characterization Of Stmtpsl Terpene Synthase-Like Genes And Their Role In Pathogen Resistance In Selaginella Tamariscina, Zhijie He, Bo Bi

Turkish Journal of Agriculture and Forestry

The biological activity and function of microbial terpene synthase-like genes from Selaginella tamariscina (StMTPSL) were investigated using molecular and biochemical approaches. After isolating and amplifying StMTPSL genes (StMTPSL1-StMTPSL6), both native and site-directed mutant forms were expressed in tobacco via Agrobacterium-mediated transformation. The resulting transgenic plants had increased expression of StMTPSL genes, enhanced monoterpene production (as confirmed by GC-MS), and significantly improved resistance to Pseudomonas syringae infection compared to nontransgenic controls. These results show that StMTPSL genes are functionally active in plants and contribute to pathogen resistance through elevated terpene biosynthesis. This study provides new insights into the role of MTPSL …

Effect Of Some Organic Fertilizers On Yield And Quality Of Olive Oil In Semiarid Conditions, İshak Bayyi̇ği̇t, Ebru Sakar

Turkish Journal of Agriculture and Forestry

This two-year field experiment evaluated the effects of different organic fertilizers on olive oil quality of the Gemlik cultivar grown under semiarid conditions in Mardin, Türkiye. Treatments of olive pomace (P1: 4, P2: 8, P3: 12 kg tree⁻¹), leonardite (L1: 1.5, L2: 3.0, L3: 4.5 kg tree⁻¹), and vermicompost (SG1: 3, SG2: 6, SG3: 9 kg tree⁻¹) were applied in a randomized complete block design with three replicates. Oils were analyzed for free acidity (FA), peroxide value, and phenolic profile using high-pressure liquid chromatography. FA ranged from 0.27% to 0.42% (as oleic acid), remaining well below the International Olive Council …

Studies On The Contribution Of Osh6 To The Functions Of Late Endosomes, William King

Theses and Dissertations

The late endosome (LE) is a hub organelle connecting endocytic, biosynthetic, exocytotic, and autophagic vesicle traffic pathways. Malfunctions of LEs are associated with multiple age dependent diseases such as Parkinson’s disease (PD). Despite this significance, how cells refurbish lipids and proteins to LEs to maintain their sustained activities are not clear. Previous studies in the model organism budding yeast show that up-regulation of a lipid transporter Osh6 (PERG6-OSH6) accumulates phosphatidylinositol-4-phosphate (PI4P) on the trans-Golgi network. It also promotes vacuole fusion and maintains the robustness of vacuoles in aged cells. Since LEs are the organelle between the TGN and vacuoles in …

Comparative Evaluation Of Curd Enriched With Essential Oils Derived From Dill, Caraway, And Cumin, Hafize Fidan, Toncho Kolev, Denis Dervish, Ivayla Dincheva, Ira Taneva, Serkan Yilmaz, Yusuf Şavşatli, Albena Stoyanova

Turkish Journal of Agriculture and Forestry

Curd cheese is a traditional dairy product that, in recent years, has increasingly been supplemented with various functional additives aimed at enhancing its aroma and flavor profile, improving overall quality, and extending shelf-life. The objective of the present study was to conduct a comparative evaluation of changes in selected physicochemical, microbiological, and sensory parameters of curd cheese enriched with 0.01% essential oils derived from dill (Anethum graveolens L.), cumin (Cuminum cyminum L.), and caraway (Carum carvi L.) fruits. Fatty acid profiling revealed a reduction in saturated fatty acids and an increase in oleic and linoleic acids in essential oil-enriched curds …

Deep Learning Technology In Multimodal Remote Sensing Data Fusion To Analyze Crop Growth And Economic Forecast, Tianlong Jiang, Ziyang Liu, Li Sun

Turkish Journal of Agriculture and Forestry

This paper integrated multimodal remote sensing (RS) data with deep learning to develop a maize growth analysis and income prediction model based on CNN (Convolutional Neural Network)-Attention and Bi-LSTM (Bidirectional Long Short-Term Memory). Utilsing Landsat 8, Sentinel-2, and Sentinel-1 satellite data, the CNN-Attention network extracts vegetation features such as NDVI (Normalised Difference Vegetation Index), EVI (Enhanced Vegetation Index), and canopy density for corn growth stage identification and prediction. The study combined these features with meteorological, soil, and market data and fed them into a Bi-LSTM model for time series analysis to forecast corn income. The method achieved 98.3% accuracy in …

Long-Term Tillage And Straw Returning Practices Enhance Soil Humus Composition, Carbon Sequestration, And Ecological–Economic Benefits, Kai Wang

Turkish Journal of Agriculture and Forestry

While straw return is widely promoted, its specific effects on soil humus composition, structure, and ecological functions are not fully understood. This study investigates the long-term impacts of different straw types and farming practices on humus composition, carbon sequestration, and ecological–economic benefits. In Hunan Province’s paddy fields, six soils with 5–30-year farming histories were selected. Treatments included a blank control, corn straw return, and rice straw return, each replicated three times. Humus structure was analyzed via infrared spectroscopy, component contents were determined by alkali extraction, and a carbon footprint model assessed emissions. Ecological economic analysis integrated soil carbon pool dynamics, …

Silicon-Mediated Enhancement Of Wheat Tolerance To Drought Stress: A Comparative Study Of Antioxidant Activity, Photosynthesis, Secondary Metabolites, And Yield, Abida Kausar, Rida Yasmeen, Shahid Iqbal, Muhammad Bilal Hafeez, Asif Mukhtiar, Sadia Azeem, Ali Raza, Samreen Nazeer, Muhammad Zubair Akram, Muhammad Kamran, Fahd Rasul, Noreen Zahra

Turkish Journal of Agriculture and Forestry

Drought stress (DS) is a major constraint on optimal plant growth and yield. Agricultural researchers have been actively exploring fertilizers that can enhance crop production under DS conditions. Silicon (Si) application has emerged as a promising strategy for managing DS in various crops. This study investigated the potential of Si soil drenching to mitigate the adverse effects of varying levels of DS (at 100%, 70%, and 40% field capacity) in wheat. Two varieties (Ujala-2016 and FSD-2008) were used to evaluate the influence of Si (2.5 mM) on antioxidant activity, oxidative burst, secondary metabolites, growth, and yield. The results indicated that …

Biomechanical Effects Of Bilateral Torsion And Skeletal Fusion: A Case Study, Linnéa Forbes

Honors Projects

As part of both a personal endeavor and an academic project, I have investigated the aetiology and treatment of seemingly idiopathic and debilitating leg pain in a patient over the past 10 years. Via collaboration with medical professionals at Cincinnati Children’s Hospital, Cincinnati Premier Physical Therapy, and Cincinnati Women’s TriHealth, I have identified sources of pain at the anatomical level. The combination of internal femoral torsion, external tibial torsion, pes planus, and bony fusions appear to be major perpetuators of the pain. An effective treatment continues to be evasive. To date, I have attempted to find answers through genetic approaches, …

Quantifying Sleep Wake Rhythms In The Hospital Environment With Digital Technologies, Carsten Skarke, Nadim El Jamal, Michael V. Genuardi, Thomas G. Brooks, Antonijo Mrčela, Nicholas F. Lahens, Makayla Cordoza, Sean Sarles, Amarachi Mbadugha, Dineth R. Karunamuni, Shikhar Gupta, Charles J. Bae, Amita Sehgal, Thomas P. Cappola, Jacob T. Gutsche, Pavan Atluri, Nimesh D. Desai, Michael A. Acker, Gregory R. Grant, Richard J. Schwab, Ilene M. Rosen, Garret A. Fitzgerald

Division of Cardiology Faculty Papers

Postoperative clinical care is prone to circadian desynchronization that may influence health outcomes. In an exploratory, feasibility-oriented and signal-exploration effort, we collected 1.8 million data points using 11 remote sensors during preoperative, in-hospital and post-discharge settings in 13 elective cardiac surgery patients (5.2% enrolled from 252 screened). We found that room traffic continued during nighttime with ≥1 visit/h. Sound levels exceeded the recommended 45 dBA threshold (51.9 ± 3.3 vs. 48.3 ± 4.2 dBA during nighttime). Brightness dropped at night (89.9 ± 87.7 to 3.7 ± 9.8 lux), but bright light exposures occurred. Ambient room temperature lacked sleep-inducing diurnal variability. …

Investigating The Intra-Host Relationships Of The Microbiota At Multiple Sites, Ariel Jose Hernandez-Leyva

Arts & Sciences Graduate Student Theses and Dissertations

The human body hosts an abundance of microbial communities that, through complex and multi-faceted interactions, interface with host physiology and help govern health and disease. Many of these interactions are beneficial and help maintain host homeostasis or contribute to the metabolic capacity of the host. Some are detrimental, potentially inducing or further exacerbating disease. All are complicated by the vast diversity of microbes that comprise the microbiota at any given site. Identifying microbes or microbial functions that influence health and disease for study and potential use as biomarkers is tantalizing, though difficult. The vast diversity of potential community compositions, redundancy …

Ultrasound-Assisted Enzymatic Extraction Improves The Antiinflammatory Activity Of Red Dragon Fruit Peel Pectin, Bao Le, Seung Hwan Yang, Hoang Dang Khoa Ta

Turkish Journal of Biology

Background/aim: Inflammatory bowel disease is a chronic inflammatory disorder characterized by excessive immune activation, primarily mediated by nitric oxide and proinflammatory cytokines. This condition encompasses ulcerative colitis and Crohn’s disease, both of which significantly impair patients’ quality of life and pose persistent challenges in clinical management. Pectin, a complex carbohydrate found in plant cell walls, has shown promise in reducing inflammation. Materials and methods: In this study, pectin was extracted from red dragon fruit peel using two methods: ultrasound-assisted extraction and ultrasound-assisted enzymatic extraction. The structural characteristics and antiinflammatory effects of the extracted pectin were evaluated in lipopolysaccharide-stimulated RAW 264.7 …

Modulating Microtubule Stability Via Α-Tubulin Acetylation Partially Restores Golgi Fragmentation In Spinal Muscular Atrophy, Peli̇n Zobaroğlu Özer, Memet Gözüböyük, Özge Çeti̇n, Niko Hensel, Güzi̇n Emecen, Adam Malik, Melissa Bowerman, Peter Claus, Hayat Erdem Yurter, Gamze Bora Akoğlu

Turkish Journal of Biology

Background/aim: Spinal muscular atrophy (SMA) is a neurodegenerative disease caused by the loss of survival of motor neuron (SMN) protein. SMN deficiency leads to perturbations of the cytoskeleton, including microtubules, which are mainly involved in motilityrelated cellular processes. However, the molecular mechanisms of microtubule dysregulation in SMA remain elusive. Alpha (α)-tubulin is a structural component of microtubules, and its posttranslational modifications affect microtubule dynamics. Here, we aimed to investigate α-tubulin acetylation and related molecular mechanisms in SMA. Materials and methods: Two different SMA mouse models, the Drosophila melanogaster model and patient-derived fibroblasts, were used in the study. Western blot and …

Development And Validation Of Kinetics And Musculoskeletal Modeling For The Milwaukee Foot Model, Maxine L. Olson

Dissertations (1934 -)

Many children are afflicted by foot and ankle pathologies which affect the ankle, midfoot, and metatarsophalangeal joints. However, a clinically feasible foot model capable of assessing multi-segment kinetics throughout the gait cycle does not exist. Similarly, a musculoskeletal foot model utilizing multiple ground reaction forces (GRF) and Milwaukee Foot Model (MFM) kinematics has not been created. The purpose of this study was to develop a clinically feasible method of modeling multi-segment foot properties without increased clinician and/or patient burden or expense. To this end, a force distribution algorithm (FDA) was created, allowing for calculation of multi-segment foot kinetics, musculoskeletal modeling, …

Ankrd2 May Alleviate Denervation-Induced Skeletal Muscle Atrophy By Inhibiting Inflammation, Yalin Zhang, Lin Zhang, Li Li, Liqin Zhang, Li Zeng, Jiaying Qiu, Zhengrong Xi, Wenwen Wang

Turkish Journal of Biology

Background/aim: Sciatic nerve injury causes a loss of skeletal muscle innervation, reduced motor function, and eventual muscle atrophy. Inflammation and increased protein degradation are key factors contributing to muscle atrophy. Inflammation is activated early during muscle atrophy and can be modulated by various factors. However, the precise role of inflammation in denervation-induced muscle atrophy remains unclear. Materials and methods: Transcriptome sequencing was used to determine that the inflammatory response occurs early during denervation-induced muscle atrophy. RT-qPCR validation of several inflammatory factors showed rapid upregulation at early stages, followed by gradual downregulation. Weighted gene coexpression network analysis of differentially expressed genes …

Protective Effect Of Pinocembrin On Zearalenone-Induced Hepatotoxicity Via Pi3k/Akt And Nrf2 Signaling In Albino Mice, Sujatha Tejavat

Turkish Journal of Biology

Background/aim: Zearalenone (ZEA) is a Fusarium-derived mycotoxin that frequently contaminates food and feed and induces hepatotoxicity in humans and animals through oxidative stress and inflammation. Pinocembrin (PCM), a naturally occurring flavonoid, has potent antioxidant and antiinflammatory properties. This study investigated the hepatoprotective effects of PCM against ZEAinduced liver injury in albino mice, with a focus on the nuclear factor erythroid 2–related factor 2 (NRF2) and phosphoinositide 3-kinase/protein kinase B (PI3K/Akt) signaling pathways. Materials and methods: Twenty-four albino male mice were allocated into four groups: (1) control (vehicle 0.05% dimethyl sulfoxide), (2) ZEA-treated (40 mg/kg body weight), (3) PCM-treated (50 mg/kg …

​Spectrophotometric Detection Of Food Additives And Pesticides By Magnetite Cross-Linked Tyrosinase Aggregates (Mcltas)​, İlker Polatoğlu

Turkish Journal of Agriculture and Forestry

In this study, tyrosinase enzyme was cross-linked with glutaraldehyde to form aggregates on the surface of activated magnetite nanoparticles, without the need for a separate support matrix. For the first time, this novel aggregate was employed for the spectroscopic detection of ascorbic acid (AA) and diazinon, as model food additives and pesticides, respectively. This technique, developed as an alternative to optical sensors, not only eliminates their drawbacks but also facilitates the recovery of cross-linked enzyme aggregates (CLEA) from the reaction medium using the incorporated magnetite nanoparticles. A spectrophotometric technique was used to measure the enzyme activity of the aggregates to …