Open Access. Powered by Scholars. Published by Universities.®

Digital Commons Network™

Open Access. Powered by Scholars. Published by Universities.®

Life Sciences

Institution
Keyword
Publication Year
Publication
Publication Type
File Type

Articles 121 - 150 of 116414

Full-Text Articles in Entire DC Network

A Resilience Early Warning Assessment Of The Maritime Supply Chain: A Case Study Of China’S New Energy Vehicle Exports, Xiuqian Chen, Liangyong Chu, Mengyao Wang, Jiayin Du, Yiming Zhang, Xiyao Xu Sep 2026

A Resilience Early Warning Assessment Of The Maritime Supply Chain: A Case Study Of China’S New Energy Vehicle Exports, Xiuqian Chen, Liangyong Chu, Mengyao Wang, Jiayin Du, Yiming Zhang, Xiyao Xu

Journal of Marine Science and Technology–Taiwan

Enhancing resilience through early warning is a critical strategy for mitigating disruption risks in the maritime supply chain (MSC). This study proposes a novel early warning assessment framework to determine the resilience of the MSC. It is referred to as a resilience early warning system. An evaluation index system for shipping enterprises is developed based on four dimensions: withstand capacity, adaptive capacity, learning capability, and the external environment. A resilience assessment model that uses the Bayesian best-worst method (BBWM) and the extension cloud model (ECM) is established to quantify MSC resilience. An early warning evaluation model based on a Bayesian …


Public-Port Throughput As An Activity Proxy For Near-Port Air Quality And Health: A Transferable Two-Scale Framework (Kaohsiung, 2017–2024), Ping-Jen Wang, Ying-Lin Hsu, Shih-Hao Chang, Bao-Tzung Wu Sep 2026

Public-Port Throughput As An Activity Proxy For Near-Port Air Quality And Health: A Transferable Two-Scale Framework (Kaohsiung, 2017–2024), Ping-Jen Wang, Ying-Lin Hsu, Shih-Hao Chang, Bao-Tzung Wu

Journal of Marine Science and Technology–Taiwan

We developed a two-scale time series framework using monthly container throughput (20-foot equivalent units, TEU) as a port activity indicator. Applied to Kaohsiung, Taiwan (2017–2024), we related TEU to near-port NO₂ and PM₂.₅ (monthly) and air quality to outpatient respiratory diagnoses (weekly) across the 2019–2020 sulfur rules and the COVID-19 pandemic. Transfer-function models indicate TEU tends to lead near-port NO₂ by 6–9 months. Structural break tests at policy dates indicate nonsignificant changes in levels and slopes, suggesting gradual rather than abrupt shifts in the activity–pollution linkage. Weekly two-pollutant distributed-lag Poisson models estimated relative risks (lags 0–8) per interquartile range (IQR) …


Impacts Of Sprouted Barley On Performance And Carcass Ultrasound Measurements In Angus-Influenced Steers During Backgrounding, Zachary C. Crump, Anthony Fernando Alberto, Bailee L. Brown, Bryce W. Roholt, Lillian L. Okamoto, Ryan A. Spurling, Robert E. Ward, Brady M. Blackett, Robert L. Harding, Sanjeewa D. Ranathunga, Kara J. Thornton Sep 2026

Impacts Of Sprouted Barley On Performance And Carcass Ultrasound Measurements In Angus-Influenced Steers During Backgrounding, Zachary C. Crump, Anthony Fernando Alberto, Bailee L. Brown, Bryce W. Roholt, Lillian L. Okamoto, Ryan A. Spurling, Robert E. Ward, Brady M. Blackett, Robert L. Harding, Sanjeewa D. Ranathunga, Kara J. Thornton

Animal, Dairy, and Veterinary Science Faculty Publications

The objective of this research was to determine the impacts of including sprouted barley (SB) in the diets of backgrounding beef steers. Angus-influenced steers (328 ± 6.59 kg) were assigned to one of four diets (n = 15/diet): a control (CON) diet, or a diet containing 5%, 10%, or 20% SB (DM basis)—replacing corn silage and some rolled barley. Individual intake and feeding behavior were monitored using Vytelle bunks. Body weight (BW) and ruminal fluid samples were collected on d 0, 30, and 60, while dry matter intake (DMI), feeding behavior, average daily gain (ADG), and gain-to-feed ratio (G:F) were …


Integration Of Freshness Monitoring And Active Packaging Technologies For Aquatic Products, Maria Ali, Abdul Waheed Ghanghro, Bheem Raj Serani, Mahrukh Zakir Sep 2026

Integration Of Freshness Monitoring And Active Packaging Technologies For Aquatic Products, Maria Ali, Abdul Waheed Ghanghro, Bheem Raj Serani, Mahrukh Zakir

Journal of Food and Drug Analysis

Aquatic products are nutritionally valuable but highly perishable, with quality loss driven by microbial spoilage, biochemical changes, including total volatile basic nitrogen (TVB-N), trimethylamine (TMA) and histamine, and physicochemical deterioration, including lipid oxidation, gas production and texture loss. Conventional packaging slows these processes but does not report real-time freshness. This review analyzes how active packaging (antimicrobial, antioxidant, enzyme-inhibiting, and oxygen-scavenging systems, including bio- and nanocomposites) can be combined with freshness monitoring technologies (colorimetric/pH indicators, gas sensors, biosensors, and digital tools such as radio frequency identification (RFID) and Internet of Things (IoT) systems) specifically for fish, shrimp, and mollusks. We first …


High Tunnel Pollinators, Miranda L. Jones, Sheriden Hansen, Kelsey Graham, Robert Nelson Schaeffer, Brent Black Sep 2026

High Tunnel Pollinators, Miranda L. Jones, Sheriden Hansen, Kelsey Graham, Robert Nelson Schaeffer, Brent Black

All Current Publications

High tunnels are used to extend the growing season. Unlike greenhouses, high tunnels are semi-permanent and not heated or cooled by a climate-control system. Instead, they use plastic sheeting to trap solar heat, allowing for season extension in temperate climates around spring and fall. Bee pollination can improve yields for several valuable crop species grown in high tunnels. Because high tunnels are largely enclosed, bees are typically released and managed within the structure. This fact sheet provides information on how to obtain and manage bee pollinators in high tunnels.


A Target-Responsive And Signal-Amplified Dna Hydrogel Biosensor For Visual And Quantitative Detection Of Aflatoxin B1, Haojie Du, Haoyue Liu, Yongshuai Li, Shiyi Wei, Xinning Wang, Yunxuan Weng, Xiaoying Zhao Sep 2026

A Target-Responsive And Signal-Amplified Dna Hydrogel Biosensor For Visual And Quantitative Detection Of Aflatoxin B1, Haojie Du, Haoyue Liu, Yongshuai Li, Shiyi Wei, Xinning Wang, Yunxuan Weng, Xiaoying Zhao

Journal of Food and Drug Analysis

Aflatoxin B1 (AFB1) poses a severe threat to food safety due to its potent carcinogenicity. To address the need for rapid and on-site detection, this study developed a colorimetric biosensor based on an AFB1-responsive DNA aptamer-cross-linked sodium alginate hydrogel. Gold nanoparticles (AuNPs) were encapsulated within the hydrogel as a visual signal reporter. The sensing mechanism relies on target-induced dissociation of aptamer crosslinkers, leading to hydrogel disintegration and release of AuNPs. The hydrogel formulation was optimized regarding sodium alginate concentration and crosslinking conditions. To enhance sensitivity, an Exonuclease I (Exo I)-triggered target recycling strategy was implemented, which amplifies hydrogel network disruption …


Developing A Deep Learning-Based Artificial Intelligence System For Detecting Scientific Misinformation On Digital Platforms, Shorouq Al-Awawdeh, Ayah Al- Jafari Sep 2026

Developing A Deep Learning-Based Artificial Intelligence System For Detecting Scientific Misinformation On Digital Platforms, Shorouq Al-Awawdeh, Ayah Al- Jafari

Middle East Journal of Communication Studies

Objectives: This study develops and evaluates an Arabic scientific misinformation detection system by fine-tuning AraBERT-base-v2. It examines the effects of early stopping and input sequence length on model performance, interprets selected linguistic characteristics associated with misleading content, and discusses the limitations of using machine-translated data.

Methodology: The study adopted a mixed-methods design, employing a systematic integration of quantitative and qualitative approaches, supported by an interpretive qualitative reading. The initial database consisted of 23,546 records, including 123 Arabic articles collected from the Akeed, Sheek, and Taqeen platforms, and 23,423 foreign-language records drawn from the GossipCop and PolitiFact collections within FakeNewsNet. After …


Broadening The Community Of Nudibranch Enthusiasts Through Multilingual Educational Programming To Increase Climate Advocacy Engagement, Richelle Li Tanner, Cintya Felix Mendivil, Ashley Lam, Lorena Muñoz, Micah Kim, Elena G. Morales Poot, Gabrielle Keeler-May Sep 2026

Broadening The Community Of Nudibranch Enthusiasts Through Multilingual Educational Programming To Increase Climate Advocacy Engagement, Richelle Li Tanner, Cintya Felix Mendivil, Ashley Lam, Lorena Muñoz, Micah Kim, Elena G. Morales Poot, Gabrielle Keeler-May

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

Environmental literacy and advocacy for environmental protections are essential components of responsible stewardship. For coastal communities, stewardship requires knowledge of ocean processes and the biological communities living within these ecosystems. While many studies highlight difficulties in engaging American audiences in environmental concern and stewardship due to hyper-individualistic societal values, tidepooling is one recreational pathway to coastal community engagement that strengthens sense of place, and therefore, responsibility to protect natural resources. We sought to broaden the tidepooling community to include more diverse voices through a participatory science program with inland city-dwelling, multilingual, and non-English speaking adults. Using nudibranchs as an environmental …


Ddrr Acts As A Dna Damage-Induced Cell Division Inhibitor In Acinetobacter Baumannii, Christian P. Lowe, Deborah Cook, Lily Hoard, Mckinnley Martin, Janelle M. Hare Sep 2026

Ddrr Acts As A Dna Damage-Induced Cell Division Inhibitor In Acinetobacter Baumannii, Christian P. Lowe, Deborah Cook, Lily Hoard, Mckinnley Martin, Janelle M. Hare

Acinetobacter baumannii DNA Damage Database

An article titled, "DdrR acts as a DNA damage-induced cell division inhibitor in Acinetobacter baumannii" published in the Journal of Bacteriology on September 9, 2026.


Comparative Potency Testing Of Diphtheria Toxoid In Guinea Pigs And Mice For In-House Diphtheria-Tetanus-Pertussis And Diphtheria-Tetanus Vaccines, Wanlop Leeden, Supanee Ummalukacholk, Orawin Mangkhaladul, Eakachai Prompetchara Sep 2026

Comparative Potency Testing Of Diphtheria Toxoid In Guinea Pigs And Mice For In-House Diphtheria-Tetanus-Pertussis And Diphtheria-Tetanus Vaccines, Wanlop Leeden, Supanee Ummalukacholk, Orawin Mangkhaladul, Eakachai Prompetchara

The Thai Journal of Pharmaceutical Sciences

Background: Diphtheria remains endemic in parts of Thailand and continues to threaten unvaccinated populations. To strengthen vaccine self-sufficiency, the Government Pharmaceutical Organization has developed in-house diphtheria–tetanus–pertussis (DTP) and diphtheria– tetanus (dT) vaccines. Potency testing of diphtheria toxoid is traditionally performed in guinea pigs; however, limitations in animal availability, cost, and logistics have prompted evaluation of alternative models.
Objectives: To compare diphtheria toxoid potency estimates of in-houseproduced DTP and dT vaccines using guinea pigs and mice, followed by a Vero cell-based toxin neutralization assay, and to assess the suitability of mice as an alternative model for potency testing.
Materials and Methods: …


Charge Modulation Of Peptide/Nucleic Acid Complexes: An Anionic Additive Enhances Gene Silencing And Crispr/Cas9 Editing By Promoting Intracellular Nucleic Acid Release, Abdulelah Alhazza, Sorour Khayyatnejad Shoushtari, Hasan Uludag, Keykavous Parang, Hamidreza Montazeri Aliabadi Sep 2026

Charge Modulation Of Peptide/Nucleic Acid Complexes: An Anionic Additive Enhances Gene Silencing And Crispr/Cas9 Editing By Promoting Intracellular Nucleic Acid Release, Abdulelah Alhazza, Sorour Khayyatnejad Shoushtari, Hasan Uludag, Keykavous Parang, Hamidreza Montazeri Aliabadi

Pharmacy Faculty Articles and Research

Introduction: Small interfering RNA (siRNA) and Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/CRISPR-associated Protein 9 (Cas9) complexes are effective approaches to temporarily downregulate protein expression via post-transcription RNA interference or permanently altering protein expression via editing genomic DNA, respectively. However, the efficient delivery of these mediators to targeted cells has been challenging, largely due to their anionic and hydrophilic nature, which hinders their interaction with the cell membrane and cellular internalization. Cell-penetrating peptides (CPPs) exhibit dual characteristics as a carrier for nucleic acid delivery, where positively charged components bind to the negatively charged nucleic acid, and the hydrophobic components …


Archives # 1 -- A Soldier’S Home (1889), Editorial Board Sep 2026

Archives # 1 -- A Soldier’S Home (1889), Editorial Board

The International Journal of Ecopsychology (IJE)

No abstract provided.


Cultivating Collaboration In Biomolviz: Key Attributes For Building A Stem Educator Community Of Practice, Pamela S. Mertz, Charmita Burch, Roderico Acevedo, Josh T. Beckham, Didem Vardar-Ulu, Kristin M. Fox, Lauren A. Genova, Rachel M. Mitton-Fry, Swati Agrawal, Daniel R. Dries, Kristen Procko Sep 2026

Cultivating Collaboration In Biomolviz: Key Attributes For Building A Stem Educator Community Of Practice, Pamela S. Mertz, Charmita Burch, Roderico Acevedo, Josh T. Beckham, Didem Vardar-Ulu, Kristin M. Fox, Lauren A. Genova, Rachel M. Mitton-Fry, Swati Agrawal, Daniel R. Dries, Kristen Procko

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

BioMolViz is an educational community of practice (CoP) focused on creating resources to improve biomolecular visual literacy instruction and assessment. The community of life science instructors developed in three phases, beginning with a small Core Team that emerged from a conference session and established the domain of interest for the CoP. In-person workshops, supported by short-term funding, drove the initial expansion of the community and the development of shared activities in Phase 2. This CoP was sustained through intentional choices about how members interact, collaborate, and share work. As the community matured in Phase 3, it was supported by longer-term …


Skin Carotenoid Scores Reflect Immune Status Among Children Living With Hiv In Tanzania, Wilbert Mbuya, Thobias Boniphace, Michael Mwagala, Peter Agrea, Nazareth M Mbilinyi, Nancy E Moran, Andrew R Dinardo, Mkunde Chachage Sep 2026

Skin Carotenoid Scores Reflect Immune Status Among Children Living With Hiv In Tanzania, Wilbert Mbuya, Thobias Boniphace, Michael Mwagala, Peter Agrea, Nazareth M Mbilinyi, Nancy E Moran, Andrew R Dinardo, Mkunde Chachage

Children’s Nutrition Research Center Staff Publications

Many individuals living with HIV experience persistent inflammation despite antiretroviral treatment, increasing their risk for cardiovascular diseases, cognitive decline, and other noncommunicable diseases. Carotenoids can inhibit this inflammation by reducing lipid peroxidation. Carotenoid intake and plasma concentrations can be approximated using a noninvasive cutaneous spectrophotometer. This study quantified skin carotenoid levels in Tanzanian children ages 5 to 15 years old (N = 185) both with and without HIV. Over 95% had low to moderate skin carotenoid scores (< 400 units). In children living with HIV, higher viral loads were linked to lower skin carotenoid scores (rho = -0.57, P < 0.001), whereas higher CD4 counts correlated with increased skin carotenoid scores (rho = 0.52, P < 0.001). Overall, carotenoid levels were low and associated with immune status, suggesting that elevated carotenoid scores correlate with lower inflammation in children living with HIV. Future studies investigating dietary carotenoid interventions to support immune function are warranted.


Editorial Vol. 13(1), September 2026, Editorial Board Sep 2026

Editorial Vol. 13(1), September 2026, Editorial Board

The International Journal of Ecopsychology (IJE)

No abstract provided.


Part Iii. Uncanny Spaces And The Trauma Of The Misplaced: Revisiting Psychological Athetosis As The Ecogothic, George Conesa Sep 2026

Part Iii. Uncanny Spaces And The Trauma Of The Misplaced: Revisiting Psychological Athetosis As The Ecogothic, George Conesa

The International Journal of Ecopsychology (IJE)

After climbing mount “Ktaadn” [Katahdin] in Maine, Thoreau observed that not all of nature was a one size-fits-all walk in the friendly woods with foxes cavorting and butterflies a-fluttering. While revisiting ecogothic perspectives (Conesa, 2024), a topical turn is made toward understanding interconnected fear responses to uncanny landscapes as a factor of previous and new traumatic events. A deep historical and comprehensive appraisal of organisms in their natural and newly found umwelten suggests that the ecogothic uncanny is a common experience of organism-territory accommodations to “place.” During these place-mind interstices, past traumatic events are amplified into newly …


Trauma Work With Horses: Compassion And Connection, Olivia Sagan Prof Sep 2026

Trauma Work With Horses: Compassion And Connection, Olivia Sagan Prof

The International Journal of Ecopsychology (IJE)

New ways of working with trauma survivors are being sought with the case being made that dominant trauma therapies have relied too heavily on verbal narration and cognitive processing.  Evidence suggests that traumatic experiences are often encoded in sensory, emotional, physiological, and relational systems that may be difficult to access through language alone. This has led to interest in the potential of body-oriented, movement-based, and experiential interventions alongside traditional talk therapies. There are also calls for exploring nature-based therapies as these have shown that engagement with natural environments may help aid the process of healing. Within this context, equine-assisted therapies …


Traumatic Experiences, Perceived Discrimination, And Psychological Distress Among Members Of Various Socially Marginalized Groups, Kimberley Matheson, Mindi D. Foster, Amy Bombay, Robyn Mcquaid, Hymie Anisman Sep 2026

Traumatic Experiences, Perceived Discrimination, And Psychological Distress Among Members Of Various Socially Marginalized Groups, Kimberley Matheson, Mindi D. Foster, Amy Bombay, Robyn Mcquaid, Hymie Anisman

The International Journal of Ecopsychology (IJE)

Perceived discrimination has consistently been shown to be associated with diminished mental health, but the psychological processes underlying this link are less well understood. The present series of four studies assessed the role of a history traumatic events in generating a proliferation of discrimination stressors and threat appraisals, which in turn predict psychological distress (depressive and posttraumatic stress symptoms) (mediation model), or whether prior traumatic events sensitize group members, such that when they encounter discrimination, the link to stress-related symptoms is heightened (moderation model). Each of the studies assessed a different marginalized group in Canada, including Indigenous peoples, Blacks, Jews, …


Gc-Ms Profiling And Antibacterial Activity Of Cold-Macerated Garlic Extracts Against Multidrug-Resistant Uropathogens, Fatima A. Khalaf, Saeed A. Fayadh Sep 2026

Gc-Ms Profiling And Antibacterial Activity Of Cold-Macerated Garlic Extracts Against Multidrug-Resistant Uropathogens, Fatima A. Khalaf, Saeed A. Fayadh

Karbala International Journal of Modern Science

The growing number of cases of multidrug-resistant (MDR) urinary tract infections has made the clinical management of urinary tract diseases a significant challenge; therefore, the need for effective adjunctive therapies cannot be overemphasized. This study evaluated the bioactive components and antibacterial efficacy of cold-macerated garlic extracts obtained using distilled water, 70% ethanol and hexane solvents against antimicrobial-resistant urinary isolates. Out of 250 urine samples that were analyzed, 124 (49.6%) showed significant microbial growth, with Escherichia coli being the most frequently isolated organism. The results of the phytochemical screening and Gas Chromatography-Mass Spectrometry (GC-MS) analysis showed that the ethanolic extract had …


Ai-Supported Analysis Of Jury Deliberation Impact Factors, Jennifer Siciliani Phd Sep 2026

Ai-Supported Analysis Of Jury Deliberation Impact Factors, Jennifer Siciliani Phd

Generative AI Teaching Activities

Students conduct a controlled, two-run generative AI jury simulation to examine how a single socio-legal variable affects simulated jury deliberation. They compare and manually code the AI-generated outcomes against peer-reviewed human jury research to evaluate the model’s accuracy, limitations, and potential biases.


Identification Of Ca2 As A Potential Candidate Gene Involved In The Therapeutic Effect Of Huatan Huoxue Decoction On Polycystic Ovary Syndrome: An Integrated Study Of Network Pharmacology, Mendelian Randomization, And Experimental Validation, Chan Zhu, Yijin Zhang, Panwei Hu, Cong Qi, Qiu Chen, Hong Yang, Jing Li Sep 2026

Identification Of Ca2 As A Potential Candidate Gene Involved In The Therapeutic Effect Of Huatan Huoxue Decoction On Polycystic Ovary Syndrome: An Integrated Study Of Network Pharmacology, Mendelian Randomization, And Experimental Validation, Chan Zhu, Yijin Zhang, Panwei Hu, Cong Qi, Qiu Chen, Hong Yang, Jing Li

Journal of Food and Drug Analysis

Purpose: Huatan Huoxue decoction (HTHXD) is effective in treating polycystic ovary syndrome (PCOS); however, its underlying mechanisms of action remain unclear. Methods: Gene targets were obtained through Mendelian randomization (MR) analysis using druggable genes from public databases and genome-wide association study data for PCOS from the FinnGen R12 database. These targets were integrated with the active ingredients and protein targets of HTHXD retrieved from the TCMSP and BATMAN-TCM databases for network pharmacology analysis. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analyses were conducted. Core targets were validated using molecular docking. Experimental validation was performed using a letrozole-induced …


Precision Approaches Improve Community Health, Roger A. Rennekamp, David Buys Sep 2026

Precision Approaches Improve Community Health, Roger A. Rennekamp, David Buys

Journal of Extension

Recent advances in data science provide Extension practitioners with access to data sorted by zip code, census tract, or neighborhood. Such hyper-local data now allows Extension personnel to assess community needs and assets at a more granular level and focus their work on the people and communities of greatest need. In this article, we introduce an approach we refer to as precision public health. Using such a precision approach to community assessment and, ultimately, programming can save money, increase the likelihood of producing measurable results, and create more manageable workloads for county-based Extension personnel.


Irrigation Management With A Field Water Balance And Virus Incidence In Dahlia Cut Flowers, Chloe Seeborg, Melanie Stock, Claudia Nischwitz, Xin Dai, Cambry Adams, Burdette Barker Sep 2026

Irrigation Management With A Field Water Balance And Virus Incidence In Dahlia Cut Flowers, Chloe Seeborg, Melanie Stock, Claudia Nischwitz, Xin Dai, Cambry Adams, Burdette Barker

Plants, Soils and Climate Student Research

Irrigation guidelines are needed for the field production of emerging specialty crops to support the sustainability and economic viability of small farms. The goal of this study was to establish crop coefficients (Kc) of dahlia (Dahlia × hybrida), a popular, profitable cut flower crop, while documenting virus infection. A two-year field study was conducted with two industry-important cultivars that vary in production timing and bloom: ‘Boom Boom White’, an earlier and mid-sized formal decorative, and ‘Café au Lait’, a later and large informal decorative bloom type. A field water balance was used to evaluate five irrigation …


Females With Urinary Incontinence Demonstrate Impaired Postural Stability, Jean L. Mccrory, Corrie Mancinelli, Kate Harrison, Samantha K. Rondini Monaco, Krystal L. Thomas Sep 2026

Females With Urinary Incontinence Demonstrate Impaired Postural Stability, Jean L. Mccrory, Corrie Mancinelli, Kate Harrison, Samantha K. Rondini Monaco, Krystal L. Thomas

Internet Journal of Allied Health Sciences and Practice

Introduction: Females with urinary incontinence (UI) have an increased risk of falls.  Few studies have quantified postural control, namely center of pressure (COP) movement and vertical ground reaction force in static and dynamic tasks, in females with UI. Purpose: The aim of our study was to examine static and perturbed postural stability in females with UI compared to unaffected females. Methods: The study design was a between-group comparison (UI vs control) on our static outcome variables of anteroposterior and mediolateral COP sway, COP displacement, average and instantaneous maximum COP velocity, and standard deviations of anteroposterior and mediolateral COP movement and …


Integration Of Lipidomic And Polygenic Risk Scores Within Contemporary Clinical Cardiovascular Risk Assessment Pathways: A Multi-Cohort Development And Validation Study, Aleksandar Dakic, Jingqin Wu, Tingting Wang, Thomas G. Meikle, Kevin Huynh, Changyu Yi, Habtamu B. Beyene, Agus Salim, Michelle Cinel, Nat Mellett, John Blangero Sep 2026

Integration Of Lipidomic And Polygenic Risk Scores Within Contemporary Clinical Cardiovascular Risk Assessment Pathways: A Multi-Cohort Development And Validation Study, Aleksandar Dakic, Jingqin Wu, Tingting Wang, Thomas G. Meikle, Kevin Huynh, Changyu Yi, Habtamu B. Beyene, Agus Salim, Michelle Cinel, Nat Mellett, John Blangero

Human Genetics Publications

Background: Guideline-recommended clinical risk scores such as AusCVDRisk underestimate cardiovascular disease (CVD) risk in a substantial proportion of individuals who later experience events, with up to 65% initially classified as low or intermediate risk. This limitation is most consequential in the intermediate-risk group, where treatment decisions are uncertain and additional risk refinement could alter management. Circulating lipid species and inherited genetic variation capture complementary molecular aspects of atherosclerotic risk that are not fully reflected by conventional clinical variables, but are not routinely incorporated into primary-care risk assessment. We investigated whether selective integration of lipidomic and genomic risk signals into AusCVDRisk …


The Effects Of Chronic Nicotine Exposure On Dopamine-Mediated Reinforcement Learning And Striatal Neurotransmission, Srishti Bose Sep 2026

The Effects Of Chronic Nicotine Exposure On Dopamine-Mediated Reinforcement Learning And Striatal Neurotransmission, Srishti Bose

Dissertations, Theses, and Capstone Projects

Tobacco is one of the most widely used substances across the United States; tobacco consumption is linked with several diseases and is one of the leading causes of preventable death in the country. Nicotine is the active substrate found in tobacco products, acting as a stimulant, which reinforces continued use. The introduction of tobacco-free options such as e-cigarettes and oral pouches has driven an increase in nicotine exposure across the population, especially in young adults. Acute nicotine use induces neuroadaptations in the mesolimbic dopaminergic system, which mediates reinforcement learning and addiction, that potentiates reward-related neurotransmission. Furthermore, there are clinical studies …


Riluzole As A Dual-Targeted Radiosensitizer For Osteosarcoma: Targeting Tumor Cells And Angiogenic Vasculature To Enhance Single High-Dose Radiotherapy Efficacy, Pooja P. Rao Sep 2026

Riluzole As A Dual-Targeted Radiosensitizer For Osteosarcoma: Targeting Tumor Cells And Angiogenic Vasculature To Enhance Single High-Dose Radiotherapy Efficacy, Pooja P. Rao

Dissertations, Theses, and Capstone Projects

Osteosarcoma (OS), the most common primary bone malignancy of children and young adults, is intrinsically radioresistant, and outcomes for patients with unresectable or metastatic disease have not improved in over four decades. Single-dose radiation therapy (SDRT) is a potent modality against radioresistant, highly vascularized sarcomas, but its application in OS is constrained by dose-dependent normal tissue toxicity. Radiosensitizers achieving tumor control at lower doses therefore offer a direct route to widening the therapeutic window. Critically, OS radioresistance is not tumor-cell-autonomous. It emerges from two coordinated compartments: aberrant DNA repair and antioxidant capacity intrinsic to the tumor cell, and a radioprotective, …


Individualized Bayesian Inference Identifies Novel Genetic Variants For Parkinson's Disease, Jin Ren, Yasaman J. Soofi, Md Asad Rahman, Qing Lu, Jinling Liu Sep 2026

Individualized Bayesian Inference Identifies Novel Genetic Variants For Parkinson's Disease, Jin Ren, Yasaman J. Soofi, Md Asad Rahman, Qing Lu, Jinling Liu

Engineering Management and Systems Engineering Faculty Research & Creative Works

Parkinson's disease (PD) is a complex neurodegenerative disorder with a significant genetic component. While genome-wide association studies (GWAS) have been instrumental in identifying genetic variants associated with PD, the reliance on large sample sizes and population-level analyses may overlook variants with lower minor allele frequencies or individual-specific relevance. Individualized Bayesian Inference (IBI) offers a promising method to complement GWAS by identifying and prioritizing candidate genetic markers at both the individual and patients-like-me subgroup levels. This study evaluates the application of IBI to PD genetics, using GWAS as a baseline for comparison. We analyzed genetic data from the Fox Insight online …


Building Wellbeing Through Nature And Adventure For Justice-Involved Youth, Lewis Kogan, Meagan Ricks, Janna Coulter, Miranda Margetts, Lori Butterfield, Ben Ukoh-Eke Sep 2026

Building Wellbeing Through Nature And Adventure For Justice-Involved Youth, Lewis Kogan, Meagan Ricks, Janna Coulter, Miranda Margetts, Lori Butterfield, Ben Ukoh-Eke

Outcomes and Impact Quarterly

Justice-involved youth often experience elevated levels of stress, mental health challenges, and reduced access to positive developmental opportunities. A nature- and adventure-based youth development program designed to strengthen resilience, self-efficacy, nature-connectedness, and well-being among justice-involved youth was piloted in 2025 to address these challenges. Pilot findings indicated improvements in resilience, self-efficacy, hopefulness, and connectedness to nature.


Improving Public Perceptions Of Dairy Production Through On-Farm Educational Tours, Drew Swartz, Justin Wyatt Clawson, Jaydee Gunnell, Elise Jenson, Dylan Waldron, Jenna Dyckman Sep 2026

Improving Public Perceptions Of Dairy Production Through On-Farm Educational Tours, Drew Swartz, Justin Wyatt Clawson, Jaydee Gunnell, Elise Jenson, Dylan Waldron, Jenna Dyckman

Outcomes and Impact Quarterly

Utah dairy producers identified public perceptions as a top concern. Utah State University Extension partnered with Cache County organizations to offer dairy farm tours. Participants reported increased knowledge, more favorable perceptions, and stronger intentions to engage with agriculture, supporting experiential education as a means to strengthen understanding of dairy production.