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The Glass Vessels From Gane Ṭal (Pp. 257–272), Brigitte Ouahnouna Jan 2025

The Glass Vessels From Gane Ṭal (Pp. 257–272), Brigitte Ouahnouna

'Atiqot

A large quantity of glass vessels, as well as glass production debris, was retrieved from Gane Ṭal. The glass repertoire exhibits a wide range of types, including bowls, a single beaker, a wineglass, bottles, cosmetic vessels and bowl-shaped oil lamps—all well-known types of the Late Roman and early Byzantine periods (fourth–fifth centuries CE). The glass-production debris found at the site includes the remains of furnace floors and a large number of raw-glass chunks, probably indicating the manufacture of raw glass.


A Byzantine-Period Funerary Chapel In The Newe Yam Dalet Neighborhood In Ashqelon (Pp. 147–158), Yulia Ustinova, Gregory Seriy Jan 2025

A Byzantine-Period Funerary Chapel In The Newe Yam Dalet Neighborhood In Ashqelon (Pp. 147–158), Yulia Ustinova, Gregory Seriy

'Atiqot

Excavations in Ashqelon’s Newe Yam Dalet neighborhood revealed a remarkable funerary chapel.The funerary complex comprises a courtyard, a tomb and a roofed chamber. The chamber floor was paved with mosaics, containing three Greek inscription; a fourth inscription was found on a marble slab in secondary use.The epigraphic evidence endorses the interpretation of the site as a cultic complex, perhaps aprivate memorial site of an individual venerated by the community.


Finds From The Bronze And Iron Ages West Of Tel Bira (With A Contribution By Hamoudi Khalaily) (Hebrew, Pp. 39*–74*; English Summary, Pp. 117–118), Nurit Feig Jan 2025

Finds From The Bronze And Iron Ages West Of Tel Bira (With A Contribution By Hamoudi Khalaily) (Hebrew, Pp. 39*–74*; English Summary, Pp. 117–118), Nurit Feig

'Atiqot

Twoexcavation areas were openedat thefoot of Tel Bira and to its west. In Area A, fivestrata were exposed. The earliest Stratumcomprised two cavities,probably used for burial, from the Intermediate Bronze Age;natural cavities, which probably servedfor burial, date to Middle Bronze Age IIA; a partially constructed burial date to Middle BronzeAge IIB–C; andtraces of walls andfloors date to the Iron Age.In Area B, three strata wereidentified: a crushed limestone floor dating from MB IIA–B;three burials dated toMB IIA–B; and a patch of dark soil thatyielded LB I pottery.The finds at the site consisted mainly ofpottery and flint toolsfrom the IntermediateBronze Age. …


The Glass Finds From The Byzantine Monastery In Naḥal Qidron,Jerusalem (Pp. 101–106), Tamar Winter Jan 2025

The Glass Finds From The Byzantine Monastery In Naḥal Qidron,Jerusalem (Pp. 101–106), Tamar Winter

'Atiqot

The glass finds from the monastery in NaḥalQidronare associated with the late Byzantine–earlyUmayyad periods, particularly the sixth–seventhcenturies CE. They resemble specimens incontemporary glass assemblages from the Jerusalem area, many of them originating inChristian ecclesiastical complexes.The assemblagecomprises some 170 small glass fragments,about 110 of which belong to windowpanes.Most of the vessels are free blown, plain andmade of translucent glass, mostly colorless, blue, greenish blue and green.


Petrographic Examination Of Intermediate Bronze Age Storagevessels From Murhan, A Site In The Harod Valley (Pp. 29–34), Anastasia Shapiro Jan 2025

Petrographic Examination Of Intermediate Bronze Age Storagevessels From Murhan, A Site In The Harod Valley (Pp. 29–34), Anastasia Shapiro

'Atiqot

The pedology of the vicinity of the site ischaracterized by brown basaltic and brownMediterranean forest soils—both of which are calcareous—covering the hills, and bybrown alluvial vertisoils covering the valleys.Eight samples were selected for petrographicexamination. These form two petrographicgroups: Group 1, from the central Jordan Valley, and Group 2, from the Jezreel Valley.


The Archaeozoology Of Bronze Age Offerings From Burial Cave 900 In Naḥal Refa’Im, Jerusalem (Pp. 75–100), Liora Kolska Horwitz Jan 2025

The Archaeozoology Of Bronze Age Offerings From Burial Cave 900 In Naḥal Refa’Im, Jerusalem (Pp. 75–100), Liora Kolska Horwitz

'Atiqot

The animal remains recovered during the salvage excavations in Cave 900 were interspersed among human skeletal remains, ceramics, weapons and ornaments. It is apparent that the faunal remains represent exclusively domestic sheep (Ovis aries) and goat (Capra hircus) that were slaughtered as part of Bronze Age mortuary rituals. This assemblage provides additional evidence for the widespread nature of the funeral feast in both the Intermediate Bronze Age and Middle Bronze Age IIB.


Excavations At The Nabatean Site Of ‘En Tamar (Pp. 49–71), Tali Erickson-Gini Jan 2025

Excavations At The Nabatean Site Of ‘En Tamar (Pp. 49–71), Tali Erickson-Gini

'Atiqot

A structure was uncovered at ‘En Tamar, located south of the Dead Sea. Most of the ceramic finds and the glass material from the structure date to the Late Roman period (second–early third centuries CE). Earlier ceramic material, dated to the Hellenistic and Early Roman periods (second century BCE–early first century CE), along with Nabatean coins from these periods, were also found. The abandonment of the site in the early third century CE fits a pattern of abandoned sites that was observed in a number of sites in the Negev, possibly due to the spread of epidemic.


The Clay Oil Lamps From Khirbat El-Ni‘Ana (Pp. 53–72), Varda Sussman Jan 2025

The Clay Oil Lamps From Khirbat El-Ni‘Ana (Pp. 53–72), Varda Sussman

'Atiqot

Excavations at Khirbat el-Ni‘ana yielded some 110 mold-made clay oil lamps, most of which were discovered in or around Tomb I. These lamps, spanning the time from the Late Roman, Byzantine and Early Islamic periods, are typologically related to products of workshops that operated in the Judean Shephelah region. The lamp assemblage includes local Khirbat el-Ni‘ana-type lamps that have heretofar not been found outside of this site.


The Church Of Bishop Johannes At Ḥorbat Barqa, Gan Yavne (With A Contribution By Leah Di Segni) (Hebrew, Pp. 79*–88*; English Summary, P. 128), Ofer Sion Jan 2025

The Church Of Bishop Johannes At Ḥorbat Barqa, Gan Yavne (With A Contribution By Leah Di Segni) (Hebrew, Pp. 79*–88*; English Summary, P. 128), Ofer Sion

'Atiqot

A Byzantine church was uncovered at the site. It was divided by two rows of pillars into a nave and two narrow aisles, and was entered from an atrium in the west via three openings. The nave was paved with a colored mosaic, of which nine rows were uncovered. The central vertical row contained a Greek dedicatory inscription, which dates the erection of the church to the time of Bishop Johannes in 511/12 CE. Fragments of liturgical furniture were found scattered in the nave, together with pottery fragments and roof tiles. This church is an important contribution to our understanding …


A Note On The Provenance Of Black Wheel-Made Vessels From A Burial Cave West Of Tel Hazor (Pp. 21–23), Anat Cohen-Weinberger Jan 2025

A Note On The Provenance Of Black Wheel-Made Vessels From A Burial Cave West Of Tel Hazor (Pp. 21–23), Anat Cohen-Weinberger

'Atiqot

A petrographic analysis was undertaken to determine the source of the raw materials used in the production of the Intermediate Bronze Age Black Wheel-Made Ware (BWMW) vessels retrieved from a burial cave west of Tel Hazor. The BWMW repertoire is limited to goblets, cups, jars, kraters, teapots and bottles; its distribution seems to be largely restricted to northern Israel, particularly to the Hula Valley. The aims of this study were to identify the raw materials that were used to manufacture the selected vessels, determine their geological sources and assess possible geographic regions of manufacture.


An Early Bronze Age I–Early Bronze Age Iii Occupation Sequence At Tamra, Western Galilee (With A Contribution By Ofer Marder)(Pp. 1–19), Howard Smithline Jan 2025

An Early Bronze Age I–Early Bronze Age Iii Occupation Sequence At Tamra, Western Galilee (With A Contribution By Ofer Marder)(Pp. 1–19), Howard Smithline

'Atiqot

The excavation at Tamra yielded important information concerning the Early Bronze Age on the eastern edge of the ‘Akko plain. The first recognizable settlement was established during EB IB. This phase was followed by an EB II settlement, whose pottery assemblage was typically dominated by a large number of Metallic Ware vessels. The major contribution of the excavation, however, is the documentation of an established settlement during EB III. The discovery of an EB III occupation that includes Khirbet Kerak Ware finally introduces this period and its pottery repertoire into the plain.


A Late Byzantine Industrial Quarter And Early Islamic-Period Finds At Ḥorbat Be’Er Shema‘ (Pp. 209–248), Tali Erickson-Gini, Benjamin J. Dolinka, Larissa Shilov Jan 2025

A Late Byzantine Industrial Quarter And Early Islamic-Period Finds At Ḥorbat Be’Er Shema‘ (Pp. 209–248), Tali Erickson-Gini, Benjamin J. Dolinka, Larissa Shilov

'Atiqot

No abstract provided.


The Inscription From Khirbat Umm Leisun, And Georgian Presence In The Holy Land (Pp. 185–193), Tamila Mgaloblishvili Jan 2025

The Inscription From Khirbat Umm Leisun, And Georgian Presence In The Holy Land (Pp. 185–193), Tamila Mgaloblishvili

'Atiqot

No abstract provided.


Population Variability Across Geographical Ranges: Perspectives And Challenges, Cleber Ten Caten, Tad Dallas Jan 2025

Population Variability Across Geographical Ranges: Perspectives And Challenges, Cleber Ten Caten, Tad Dallas

Faculty Publications

Populations fluctuate over time and across geographical space, and understanding how different factors contribute to population variability is a central goal in population ecology. There is a particular interest in identifying trends of population variability within geographical ranges as population densities of species can fluctuate substantially across geographical space. A common assumption is that populations vary more near species geographical range edges because of unsuitable environments and higher vulnerability to environmental variability in these areas. However, empirical data rarely support this expectation, suggesting that population variability is not related to its position within species geographical ranges. We propose that performance …


Optimizing Ethanol-Water Cosolvent Systems For Green Supercritical Carbon Dioxide Extraction Of Muscadine Grape Pomace Polyphenols, Arda Tuhanioglu, Sumanjot Kaur, Gabriel Laquete De Barros, Safoura Ahmadzadeh, Renee Threlfall, Ali Ubeyitogullari Jan 2025

Optimizing Ethanol-Water Cosolvent Systems For Green Supercritical Carbon Dioxide Extraction Of Muscadine Grape Pomace Polyphenols, Arda Tuhanioglu, Sumanjot Kaur, Gabriel Laquete De Barros, Safoura Ahmadzadeh, Renee Threlfall, Ali Ubeyitogullari

Food Science Faculty Publications and Presentations

This study evaluated the ethanol-water modified (50%, v/v) supercritical carbon dioxide (SC-CO2) for the extraction of polyphenols from muscadine grape (Vitis rotundifolia Michgx.) pomace and compared with conventional solvent extractions (ethanol-water and HCl-methanol). The process was optimized with a central composite response surface design consisting of three levels of three independent variables: pressure (20-40 MPa), temperature (40-60 degrees C), and cosolvent concentration (5-15%) to maximize three responses: total phenolic content (TPC), total flavonoid content (TFC), and resveratrol yields. The optimal conditions were determined as 20 MPa, 60 degrees C, and 15% cosolvent concentration with TPC, TFC, and resveratrol yields of …


Neolithic Flint Workshops At Giv‘At Rabi (East) In Lower Galilee (Pp. 63–83), Omry Barzilai, Ianir Milevski Israel Antiquities Authority Jan 2025

Neolithic Flint Workshops At Giv‘At Rabi (East) In Lower Galilee (Pp. 63–83), Omry Barzilai, Ianir Milevski Israel Antiquities Authority

'Atiqot

This article presents the flint assemblages from the Neolithic workshops exposed at Giv‘at Rabi (East), which produced bidirectional blades, unidirectional blades and bifacial tools. The Neolithic blades were produced from wide cores with relatively few preparations. The bifacial tools included unfinished and finished cortical axes and adzes. These techno-typological characteristics suggest that the workshops at Giv‘at Rabi (East) should be dated to the Final Pre-Pottery Neolithic (PPNB) and the Early Pottery Neolithic (PN) periods. The discovery of the Neolithic workshops at Giv‘at Rabi (East) contributes to our understanding of the organization of the lithic industries in the region of Lower …


Petrographic Study Of Selected Mamluk-Period Pottery From Khirbat Din‘Ila (Pp. 105–112), Anastasia Shapiro Jan 2025

Petrographic Study Of Selected Mamluk-Period Pottery From Khirbat Din‘Ila (Pp. 105–112), Anastasia Shapiro

'Atiqot

Twenty-seven vessels dated to the Mamluk period from Khirbat Din‘ila were selected and sampled for petrographic examination. The vessels were divided into four petrographic groups. It was found that all the soil types are known for their use in pottery production throughout human history, as are the use of quartz sand or crushed calcite tempers.


A Bread Stamp From Ḥorbat Ma‘On (Pp. 31–36), Leah Di Segni Jan 2025

A Bread Stamp From Ḥorbat Ma‘On (Pp. 31–36), Leah Di Segni

'Atiqot

A pottery bread stamp was discovered in Stratum IV at Ḥorbat Ma‘on, dated to the end of the Byzantine period. The bread stamp has a disk-shaped base and a round knob handle. The handle top is decorated with a cross and the base of the stamp bears a Greek inscription that reads: “Blessing of (Saint?) Stephen”. The inscription indicates that the stamp was used for preparing buns that were handed out at a church as a memento of a visit to that church. It is proposed that the excavated complex at Ḥorbat Ma‘on included a church of St. Stephen and …


The Burial Ground At Ḥorbat Za‘Aq (Pp. 1–23), Irit Yezerski Jan 2025

The Burial Ground At Ḥorbat Za‘Aq (Pp. 1–23), Irit Yezerski

'Atiqot

Thirty-two rock-cut burial tombs were documented in the burial ground excavated at Ḥorbat Za‘aq, in the southern Judean Shephelah. The majority of the tombs date to Iron Age IIB–III; one tomb (Tomb 13) dates to MB IIB–C; another (Tomb 48), to the Roman or Byzantine period; and two tombs (Tombs 22 and 23) were reused in the Early Roman period. These tombs probably belonged to families who lived in villages or farms in the vicinity of the burial ground. The Iron Age IIB–III rock-cut tombs at H. Za‘aq were hewn according to local architectural traditions; however, they share certain features …


A Roman Milestone From The ‘Third Mile Estate’, Ashqelon (Pp. 223–228), Israel Roll Jan 2025

A Roman Milestone From The ‘Third Mile Estate’, Ashqelon (Pp. 223–228), Israel Roll

'Atiqot

A Roman milestone was uncovered 50 m to the northwest of the Byzantine estate buildings. It is a segment of a marble column, roughly cut at one end and broken at the other. The milestone segment bears two lapidary Latin inscriptions: one from the time of Elagabalus (218–222 CE), the other from the reign of Diocletian (284–305 CE).


Glass Finds From Ketef Hinnom, Jerusalem (Pp. 35–44), Natalya Katsnelson Jan 2025

Glass Finds From Ketef Hinnom, Jerusalem (Pp. 35–44), Natalya Katsnelson

'Atiqot

The excavations at Ketef Hinnom yielded 347 glass fragments, including a large amount of Ottoman-period and modern glass. The Roman-period glass fragments date to the first–early third centuries CE, including two bowls, a beaker, a jug, candlestick bottles and a small cosmetic bottle. A significant find is a rare, mold-blown ‘Sidonian’ juglet. The few glass finds that can be associated with the Byzantine period comprise a wineglass, an oil lamp, two small glass tesserae and several windowpane fragments.


Agricultural And Industrial Installations And Burial Caves From The Roman And Byzantine Periods At Zur Yig’Al (Hebrew, Pp. 123–144; English Summary, Pp. 90*–91*), Etan Ayalon Jan 2025

Agricultural And Industrial Installations And Burial Caves From The Roman And Byzantine Periods At Zur Yig’Al (Hebrew, Pp. 123–144; English Summary, Pp. 90*–91*), Etan Ayalon

'Atiqot

A survey and trial excavations were carried out in preparation for the establishment of the Zur Yig’al settlement in the Sharon plain. Sixteen winepresses of various sizes were identified in the survey, some paved with white mosaics and equipped with screw presses. Also recorded were thirteen cisterns, seven towers, five burial caves, two cist tombs, six limekilns, cupmarks, piles of small stones, rock cuttings, natural caves, many agricultural terraces and some unidentifiable installations. The area seems to have been used as marginal agricultural land, worked for a relatively short period of time by one or more of the nearby settlements, …


Coronavirus Disease 2019 (Covid-19) Real World Data Infrastructure: A Big-Data Resource For Study Of The Impact Of Covid-19 In Patient Populations With Immunocompromising Conditions, James M. Crawford, Lynne Penberthy, Ligia A. Pinto, Keri N. Althoff, Magdalene M. Assimon, Oren Cohen, Laura Gillim, Tracy L. Hammonds, Shilpa Kapur, Harvey W. Kaufman, David Kwasny, Jean W. Liew, William A. Meyer 3rd, Shannon L. Reynolds, Cheryl B. Schleicher, Suki Subbiah, Catherine Theruviparampil, Zachary S. Wallace, Jeremy L. Warner, Suhyeon Yoon, Yonah C. Ziemba Jan 2025

Coronavirus Disease 2019 (Covid-19) Real World Data Infrastructure: A Big-Data Resource For Study Of The Impact Of Covid-19 In Patient Populations With Immunocompromising Conditions, James M. Crawford, Lynne Penberthy, Ligia A. Pinto, Keri N. Althoff, Magdalene M. Assimon, Oren Cohen, Laura Gillim, Tracy L. Hammonds, Shilpa Kapur, Harvey W. Kaufman, David Kwasny, Jean W. Liew, William A. Meyer 3rd, Shannon L. Reynolds, Cheryl B. Schleicher, Suki Subbiah, Catherine Theruviparampil, Zachary S. Wallace, Jeremy L. Warner, Suhyeon Yoon, Yonah C. Ziemba

School of Medicine Faculty Publications

Background. We developed a United States–based real-world data resource to better understand the continued impact of the coronavirus disease 2019 (COVID-19) pandemic on immunocompromised patients, who are typically underrepresented in prospective studies and clinical trials. Methods. The COVID-19 Real World Data infrastructure (CRWDi) was created by linking and harmonizing de-identified HealthVerity medical and pharmacy claims data from 1 December 2018 to 31 December 2023, with severe acute respiratory syndrome coronavirus 2 virologic and serologic laboratory data from major commercial laboratories and Northwell Health; COVID-19 vaccination data; and, for patients with cancer, 2010 to 2021 National Cancer Institute Surveillance, Epidemiology, and …


A Cargo Of Lead Ingots From An Eleventh–Thirteenth-Centuries Ce Shipwreck Off The Ashqelon Coast (Hebrew, Pp. 131–137; English Summary, P. 76*), Ehud Galili, Baruch Rosen Jan 2025

A Cargo Of Lead Ingots From An Eleventh–Thirteenth-Centuries Ce Shipwreck Off The Ashqelon Coast (Hebrew, Pp. 131–137; English Summary, P. 76*), Ehud Galili, Baruch Rosen

'Atiqot

Fifty-seven lead ingots were discovered on the seabed west of Tel Ashqelon, their total average weight reaching c. 4 tons. These finds shed light on the nature of shipping and commerce along the Ashqelon coast during the eleventh–thirteenth centuries CE. A survey of the written evidence, concerning the importation of lead to Israel, is encountered, as well as an attempt to reconstruct the vessel type that transported the lead and the reason for its wreckage.


Remains From The Medieval And Ottoman Periods On The Eastern Hill Of Tell Jatt (Area D) (Hebrew, Pp. 47*–51*; English Summary, P. 173), Eli Yannai Jan 2025

Remains From The Medieval And Ottoman Periods On The Eastern Hill Of Tell Jatt (Area D) (Hebrew, Pp. 47*–51*; English Summary, P. 173), Eli Yannai

'Atiqot

On the eastern hill of Tell Jatt were uncovered remains from the medieval (twelfth–thirteenth centuries CE) and Ottoman periods. The excavation results demonstrated that contrary to the finds on the tell, which do not post-date the Roman period, the eastern spur of the tell was established during the Byzantine period and continued to be settled in the Crusader, Mamluk and Ottoman periods.


A Decorated Bronze Platter From Kafr Misr (Pp. 227–241), Sara Lutan-Hassner Jan 2025

A Decorated Bronze Platter From Kafr Misr (Pp. 227–241), Sara Lutan-Hassner

'Atiqot

The finding circumstances of the platter from Kafr Misr could not enlighten us regarding its date, artistic origins or provenance. Therefore, a detailed iconographic and stylistic analysis of the images portrayed on the platter was undertaken, in an attempt to decipher its enigma. The artistic analysis points to Christian iconography, as manifested in Byzantine art of the tenth and eleventh centuries CE. The article discusses relevant comparisons to other artistic data from the period and offers a reconstruction of the route of the platter to Kafr Misr in the Lower Galilee.


Survey And Salvage Excavations On The Menashe Spur, Near Ḥorbat Bareqet And Kibbutz Regavim (Hebrew, Pp. 83–107; English Summary, Pp. 59–61), Amir Gorzalczany Jan 2025

Survey And Salvage Excavations On The Menashe Spur, Near Ḥorbat Bareqet And Kibbutz Regavim (Hebrew, Pp. 83–107; English Summary, Pp. 59–61), Amir Gorzalczany

'Atiqot

A large area, located in the catchment basin of Naḥal ‘Ada, was surveyed and consequently excavated, revealing a large number of walls and installations. Among the installations are many stone heaps and square towers. A trapezoidal enclosure was examined and partly excavated; it was most likely used to store agricultural produce. The remains in this area are probably part of an Iron Age satellite settlement, under the aegis of the city of Dor. The enclosures located in the area were dated to the Roman and Byzantine periods, and were possibly connected with the city of Caesarea. During the Islamic period …


Underground Reservoirs From The Crusader Period And Later Remains Next To And North Of The Synagogue At Moza (Hebrew, Pp. 135–144; English Summary, Pp. 73*–75*), Zvi Greenhut Jan 2025

Underground Reservoirs From The Crusader Period And Later Remains Next To And North Of The Synagogue At Moza (Hebrew, Pp. 135–144; English Summary, Pp. 73*–75*), Zvi Greenhut

'Atiqot

Three underground vaults exposed next to and north of the synagogue at Moza were part of a subterranean water reservoir of a Crusader-period building that existed at the site. Two of the ashlar-built vaults are parallel, with pointed ceilings treated with dark gray plaster. The vaults were separated by three arches borne by square pillars, constructed from ashlars bearing the typical Crusader diagonal dressing and mason’s marks. Apparently, water was conveyed to the vaults via a channel from nearby springs. The third vault incorporated a chute that drained the water into it. Above the underground water reservoir were a Crusader …


A Jewish Mausoleum Of The Roman Period At Qiryat Shemu’El, Tiberias (Pp. 7*–29*), Fanny Vitto Jan 2025

A Jewish Mausoleum Of The Roman Period At Qiryat Shemu’El, Tiberias (Pp. 7*–29*), Fanny Vitto

'Atiqot

The tomb, constructed from large, roughly dressed basalt stones, consisted of a courtyard, a burial chamber surrounded by two stories of loculi (kokhim) and a large subterranean chamber. Part of a basalt-stone door, which originally sealed the tomb opening, was found; it was carved in imitation of a paneled wooden door, and originally swung on hinges, one of which survived in situ. The finds within the tomb included pottery and glass vessels, an iron nail and a limestone ossuary, mostly dating to the end of the first–early second centuries CE; a magical amulet, representing a reaper and incised with a …


Geographic Disparities Impacting Oral Vaccine Performance: Observations And Future Directions, Rachel M Burke, Sasirekha Ramani, Julia Lynch, Laura V Cooper, Haeun Cho, Ananda S Bandyopadhyay, Carl D Kirkwood, A Duncan Steele, Gagandeep Kang Jan 2025

Geographic Disparities Impacting Oral Vaccine Performance: Observations And Future Directions, Rachel M Burke, Sasirekha Ramani, Julia Lynch, Laura V Cooper, Haeun Cho, Ananda S Bandyopadhyay, Carl D Kirkwood, A Duncan Steele, Gagandeep Kang

Faculty, Staff and Students Publications

Oral vaccines have several advantages compared with parenteral administration: they can be relatively cheap to produce in high quantities, easier to administer, and induce intestinal mucosal immunity that can protect against infection. These characteristics have led to successful use of oral vaccines against rotavirus, polio, and cholera. Unfortunately, oral vaccines for all three diseases have demonstrated lower performance in the highest-burden settings where they are most needed. Rotavirus vaccines are estimated to have >85% effectiveness against hospitalization in children < 12 months in countries with low child mortality, but only ~65% effectiveness in countries with high child mortality. Similarly, oral polio vaccines have lower immunogenicity in developing country settings compared with high-resource settings. Data are more limited for oral cholera vaccines, but suggest lower titers among children compared with adults, and, for some vaccines, lower efficacy in endemic settings compared with non-endemic settings. These disparities are likely multifactorial, and available evidence suggests a role for maternal factors (e.g. transplacental antibodies, breastmilk), host factors (e.g. genetic polymorphisms-with the best evidence for rotavirus-or previous infection), and environmental factors (e.g. gut microbiome, co-infections). Overall, these data highlight the rather ambiguous and often contradictory nature of evidence on factors affecting oral vaccine response, cautioning against broad extrapolation of outcomes based on one population or one vaccine type. Meaningful impact on performance of oral vaccines will likely only be possible with a suite of interventions, given the complex and multifactorial nature of the problem, and the degree to which contributing factors are intertwined.