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Articles 601 - 630 of 40157
Full-Text Articles in Entire DC Network
Collegiate Basketball Athletes' Achilles Tendon Echogenicity Decreases Over A Season With No Difference In Size, Colton Glissmeyer, Malorie Wilwand, Camille Nguyen, Michael Davie, A. Wayne Johnson
Collegiate Basketball Athletes' Achilles Tendon Echogenicity Decreases Over A Season With No Difference In Size, Colton Glissmeyer, Malorie Wilwand, Camille Nguyen, Michael Davie, A. Wayne Johnson
Library/Life Sciences Undergraduate Poster Competition 2026
3rd Place - Open House Presentation
- The Achilles tendon (AT) enables movements essential to athletes.
- Early AT injury indicators include increased cross-sectional area (CSA), thickening, and decreased echogenicity.
- This study investigated the change in AT CSA, thickness, and echogenicity in collegiate basketball athletes across one season.
Cholesterol‑Containing Membranes Decrease The Helicity Of The Snare Protein Snap‑25, Christopher E. Hunt Jr., Jason T. Carlson, Michael B. Connell, Fatima D. Dagohoy, Mike Sumison, Jonathan Madsen, Chase M. Tingen, Azer E. White, Tanner M. Blocker, Dixon J. Woodbury
Cholesterol‑Containing Membranes Decrease The Helicity Of The Snare Protein Snap‑25, Christopher E. Hunt Jr., Jason T. Carlson, Michael B. Connell, Fatima D. Dagohoy, Mike Sumison, Jonathan Madsen, Chase M. Tingen, Azer E. White, Tanner M. Blocker, Dixon J. Woodbury
Library/Life Sciences Undergraduate Poster Competition 2026
Neurotransmitter release in neurons requires membrane fusion between synaptic vesicles and the presynaptic membrane. Lipids in both membranes merge through the action of SNARE proteins including SNAP-25. Changes in SNAP-25 structure or lipid composition likely modify this process. SNAP-25 has two isoforms, SNAP-25A (25A) and SNAP-25B (25B), the expression patterns of these isoforms vary throughout different brain regions and neuronal developmental stages. In vivo SNAP-25 anchors to the presynaptic membrane via attachment of palmitic acid to at least one of the four cysteines. Here we show mixing SNAP-25 (not palmitoylated) with liposomes alters both protein structure and lipid properties. Using …
C-Fms Expresses In Early Progenitor Cells & Myeloid-Lineage Leukocytes Based On Analyzing Lineage Markers And Mapping On Ly6c X Cd31 Plots In Bone Marrow, Jane Lundgren, Kelly Amsden, Evan Boesl, Victoria Hall, Emily Shakespear, Pam Van Ry, Sandra Hope
C-Fms Expresses In Early Progenitor Cells & Myeloid-Lineage Leukocytes Based On Analyzing Lineage Markers And Mapping On Ly6c X Cd31 Plots In Bone Marrow, Jane Lundgren, Kelly Amsden, Evan Boesl, Victoria Hall, Emily Shakespear, Pam Van Ry, Sandra Hope
Library/Life Sciences Undergraduate Poster Competition 2026
The Mafia mouse model expresses the green fluorescent protein (GFP) in cells that utilize the macrophage-specific c-fms promoter. The c-fms promoter controls expression of receptor for Colony Stimulating Factor 1. We hypothesize that this promotor may be utilized in bone marrow progenitor cells in addition to the mature cell expression already known in macrophage lineage cells. For this study, bone marrow cells were analyzed by flow cytometry for the expression of c-fms, early progenitor markers, and lineage-specific markers. Expression was also mapped on a Ly6CxCD31 plot, which has been used to distinguish cells based on developmental stage and lineage. This …
Cd6-Knockout Car-T Cells Display Enhanced Cytotoxicity Against Lymphoma Cell Line, Annie Larson, Alka Gaur, Nate Neyman, Collin Mickelson, K. Scott Weber
Cd6-Knockout Car-T Cells Display Enhanced Cytotoxicity Against Lymphoma Cell Line, Annie Larson, Alka Gaur, Nate Neyman, Collin Mickelson, K. Scott Weber
Library/Life Sciences Undergraduate Poster Competition 2026
Chimeric antigen receptor (CAR)-T cells are genetically engineered T cells that target surface antigens on cancer cells, showing remarkable effectiveness in treating blood cancers [1]. However, CAR-T cells are currently not effective in treating solid tumors, as the tumor microenvironment poses physical and metabolic barriers to effective CAR-T cell function. A notable strategy for increasing CAR-T cell cytotoxicity in a tumor microenvironment is knocking out or overexpressing some genes of the T cell.
Reducing The Cost Of Muscle Volume Research, Jacob Green, Josh Vandenakker, Malorie Wilwand, Micahel Davie, Steven D. Arnold, A. Wayne Johnson
Reducing The Cost Of Muscle Volume Research, Jacob Green, Josh Vandenakker, Malorie Wilwand, Micahel Davie, Steven D. Arnold, A. Wayne Johnson
Library/Life Sciences Undergraduate Poster Competition 2026
Honorable Mention - Open House Presentation
PROBLEM: Current MRI segmentation options consist of manual segmentation, requiring up to 6 hours per subject, or using segmentation companies that charge about 400$ per MRI.
Role Of Wadsley Defects And Cation Disorder To Enhance Monb12O33 Diffusion, Cj Sturgill, Manish Kumar, Nima Karimitari, Iva Millisavljevic, Coby S. Collins, Aaron Hegler, Hsin-Yun Joy Chao, Santosh Kiran Balijepalli, Scott T. Misture, Christopher Sutton, Morgan Stefik
Role Of Wadsley Defects And Cation Disorder To Enhance Monb12O33 Diffusion, Cj Sturgill, Manish Kumar, Nima Karimitari, Iva Millisavljevic, Coby S. Collins, Aaron Hegler, Hsin-Yun Joy Chao, Santosh Kiran Balijepalli, Scott T. Misture, Christopher Sutton, Morgan Stefik
Faculty Publications
Wadsley-Roth (WR) niobates have emerged as high-rate anode materials that can combine rapid ionic diffusion with good electronic conductivity. WR compounds have been defect-enhanced by limited annealing, however, such materials often contain multiple types of defects. In particular, both Wadsley defects (variable block size) and transition metal disorder have the potential to modify transport rates, however the corresponding effects are not well understood mechanistically. Here, MoNb12O33 (MNO) was calcined at two different temperatures to compare a defect-rich condition (MNO-800) with a proximal order-rich condition (MNO-900) as assessed through XRD, XANES, EXAFS, and STEM characterizations. Galvanostatically cycled lithium half cells of …
Monitoring Relapse In Post-Transplant Acute Myeloid Leukemia Requires Integrated Assessment, With Flow Cytometry Showing The Highest Efficacy, Wei J Wang, Sa A Wang, Hong Fang, Qing Wei, Shimin Hu, Sanam Loghavi, Gheath Al-Atrash, Chenxuan Zang, Peng Wei, Jeffrey L Medeiros, Wei Wang
Monitoring Relapse In Post-Transplant Acute Myeloid Leukemia Requires Integrated Assessment, With Flow Cytometry Showing The Highest Efficacy, Wei J Wang, Sa A Wang, Hong Fang, Qing Wei, Shimin Hu, Sanam Loghavi, Gheath Al-Atrash, Chenxuan Zang, Peng Wei, Jeffrey L Medeiros, Wei Wang
Faculty, Staff and Student Publications
No abstract provided.
Bio 230 - Microbiology, Sarah Moroianu
Bio 230 - Microbiology, Sarah Moroianu
Open Educational Resources
This open educational resource (OER) syllabus is designed for BIO 230: Microbiology at Lehman College, City University of New York (CUNY), a single-semester introductory microbiology course for non-biology majors such as Nursing, Dietetics, Health Education, and Physical Education. The course reviews microbial structure, metabolism, genetics, and microbial ecology, with applied emphasis on infectious disease, antimicrobial drugs, host immune defenses, and microbial diseases. The syllabus aligns course content with the freely available OpenStax Microbiology textbook (Parker et al., CC BY 4.0) and reflects accessibility best practices consistent with CUNY guidelines.
Artificial Intelligence In Mycology: A Systematic Review Of Species Identification, Biotechnological Assessment, And Explainable Deep Learning Methods, Fati̇h Eki̇nci̇, Mehmet Serdar Güzel, Ilgaz Akata
Artificial Intelligence In Mycology: A Systematic Review Of Species Identification, Biotechnological Assessment, And Explainable Deep Learning Methods, Fati̇h Eki̇nci̇, Mehmet Serdar Güzel, Ilgaz Akata
Turkish Journal of Botany
This review offers a comprehensive analysis of the expanding role of artificial intelligence (AI) in mycological research. It highlights how AI supports the identification of fungal taxa at both microscopic and macroscopic levels, facilitates the detection of toxic species, contributes to ecological mapping, aids in discovering new fungal bioproducts, and enhances precision agriculture practices. Advanced techniques such as convolutional neural networks, you only look once, U-shaped network (UNet), and residual network have demonstrated strong performance in classification, segmentation, and object detection tasks. Additionally, explainable AI (XAI) methods like gradient-weighted class activation mapping (Grad-CAM), local interpretable model-agnostic explanations (LIME), and SHapley …
Synthetic Lethality Between Rb-Loss And E2f3 Inhibition In Small Cell Cancers Targeted By Pyrimidine Synthesis Blockade, Evan R. Abt, Liang Wang, Grigor Varuzhanyan, Jack Freeland, Tian He, Guadalupe M. Peña-Garcia, Lauryn Ruegg, Jami Mclaughlin, Donghui Cheng, Nikolas G. Balanis, Chia-Chun Chen, Yang Xu, Yi Xing, Sanaz Memarzadeh, Caius G. Radu, Thomas G. Graeber, Owen N. Witte
Synthetic Lethality Between Rb-Loss And E2f3 Inhibition In Small Cell Cancers Targeted By Pyrimidine Synthesis Blockade, Evan R. Abt, Liang Wang, Grigor Varuzhanyan, Jack Freeland, Tian He, Guadalupe M. Peña-Garcia, Lauryn Ruegg, Jami Mclaughlin, Donghui Cheng, Nikolas G. Balanis, Chia-Chun Chen, Yang Xu, Yi Xing, Sanaz Memarzadeh, Caius G. Radu, Thomas G. Graeber, Owen N. Witte
Department of Pharmacology, Physiology, and Cancer Biology Faculty Papers
Small cell carcinoma is a highly lethal cancer variant often found with neuroendocrine (NE) features, as exemplified by small cell lung cancer and small cell NE prostate cancer (SCPC). A genome-wide CRISPR dependency screen using SCPC models generated through human prostate cell transformation identifies a requirement for the transcription factor E2F3. E2F3 dependency is linked to RB inactivation, a near universal occurrence across small cell cancers. The requirement for E2F3 is shared by RB-deficient cells originating from the prostate, lung, and adnexa. In RB-deficient cancer cells, E2F3 inhibition restrains cell cycle progression, proliferation, and tumor growth in vivo. Inhibition of …
Fecal Carbohydrate-Degrading Bacteria Are Associated With Reduced Incidence Of Lower Gastrointestinal Gvhd, Christopher Fan, Tomo Hayase, Chia-Chi Chang, Israel K Glover, Ivonne I Flores, Lauren K Mcdaniel, Miriam R Ortega, Christopher A Sanchez, Rawan K El-Himri, Alexandria N Brown, Jennifer L Karmouch, Mohamed A Jamal, Saira S Ahmed, Taylor M Halsey, Yimei Jin, Wen-Bin Tsai, Rishika Prasad, Altai Enkhbayar, Aqsa Mohammed, Maren Schmiester, Ashish Damania, Nadim J Ajami, Jennifer A Wargo, Christine B Peterson, Gabriela Rondon, Taha Al-Juhaishi, Amin M Alousi, Jeffrey J Molldrem, Richard E Champlin, Elizabeth J Shpall, Eric Martens, Cesar A Arias, Robert R Jenq, Eiko Hayase
Fecal Carbohydrate-Degrading Bacteria Are Associated With Reduced Incidence Of Lower Gastrointestinal Gvhd, Christopher Fan, Tomo Hayase, Chia-Chi Chang, Israel K Glover, Ivonne I Flores, Lauren K Mcdaniel, Miriam R Ortega, Christopher A Sanchez, Rawan K El-Himri, Alexandria N Brown, Jennifer L Karmouch, Mohamed A Jamal, Saira S Ahmed, Taylor M Halsey, Yimei Jin, Wen-Bin Tsai, Rishika Prasad, Altai Enkhbayar, Aqsa Mohammed, Maren Schmiester, Ashish Damania, Nadim J Ajami, Jennifer A Wargo, Christine B Peterson, Gabriela Rondon, Taha Al-Juhaishi, Amin M Alousi, Jeffrey J Molldrem, Richard E Champlin, Elizabeth J Shpall, Eric Martens, Cesar A Arias, Robert R Jenq, Eiko Hayase
Faculty, Staff and Student Publications
Lower gastrointestinal graft-versus-host disease (LGI-GVHD) carries morbidity and mortality for patients undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT), with critical contributions from the intestinal microbiome. In a retrospective cohort of metagenomic sequencing of stool from patients with allo-HSCT (N = 90), we found that a reduction in specific Parabacteroides and Bacteroides species around the time of engraftment contributes to LGI-GVHD risk. Given the known diverse carbohydrate-degrading functionality of these bacteria, we investigated gene abundances for carbohydrate-active enzymes (CAZymes) and found that Parabacteroides merdae, P distasonis, and Bacteroides ovatus abundances were significantly correlated with CAZymes in patients who did not develop …
Genome-Wide Crispr Screen Identifies A Cytokine-Enhancer Circuit Driving Hif-2Α Activation In Renal Cancer, Jun Fang, Jeremy M Simon, Tao Wang, Yunpeng Gao, Xianju Bi, Lianxin Hu, Chengheng Liao, Cheng Zhang, Yayoi Adachi, Jin Zhou, Hongyi Liu, Qian Liang, James A Nathan, Ram Mani, James Brugarolas, Qing Zhang
Genome-Wide Crispr Screen Identifies A Cytokine-Enhancer Circuit Driving Hif-2Α Activation In Renal Cancer, Jun Fang, Jeremy M Simon, Tao Wang, Yunpeng Gao, Xianju Bi, Lianxin Hu, Chengheng Liao, Cheng Zhang, Yayoi Adachi, Jin Zhou, Hongyi Liu, Qian Liang, James A Nathan, Ram Mani, James Brugarolas, Qing Zhang
Faculty, Staff and Student Publications
Resistance to HIF-2α inhibitors such as Belzutifan underscores the need to better understand how HIF-2α is transcriptionally regulated in clear cell renal cell carcinoma (ccRCC). Here, we uncover a cytokine-driven enhancer mechanism that sustains HIF-2α expression through the JAK1-STAT3 signaling pathway. Using a genome-wide CRISPR screen in VHL-deficient ccRCC cells, we identified SOCS3 as a key negative regulator of HIF-2α. Mechanistically, loss of SOCS3 activates JAK1-STAT3 signaling, leading to the recruitment of STAT3 to distal enhancers upstream of EPAS1 that physically loop to its promoter to drive HIF-2α transcription. This cytokine-enhancer circuit was recapitulated in ccRCC patient samples and functionally …
Best Integrated Writing Spring 2026 - Complete Edition, Wright State University School Of Humanities And Cultural Studies, Tracy Smith, Kristie Mckiernan
Best Integrated Writing Spring 2026 - Complete Edition, Wright State University School Of Humanities And Cultural Studies, Tracy Smith, Kristie Mckiernan
Best Integrated Writing
Best Integrated Writing includes excellent student writing from Integrated Writing courses taught at Wright State University.
Tlr3 Mediated Type I Interferon Response In Mammalian Cell Defense Against Cryptosporidium Parvum Infection., Anjelica Matias
Tlr3 Mediated Type I Interferon Response In Mammalian Cell Defense Against Cryptosporidium Parvum Infection., Anjelica Matias
Biochemistry and Molecular Biology
Cryptosporidium parvum is a major cause of a diarrheal disease which affects many children in the USA as well as the rest of the world, yet the contribution of its double stranded RNA (dsRNA) viral symbiont, Cryspovirus (CSpV1) to host innate immunity remains unclear. This study investigated whether CSpV1 activates Toll Like Receptor 3 (TLR3) signaling pathways and downstream Interferon type I (IFN I) responses in mammalian intestinal epithelial cells. Confluent Human Ileocecal Colorectal Adenocarcinoma cells (HCT8) were exposed to CSpV1, and the expression levels of Tumor Necrosis Factor Receptor-Associated Factor 3 (TRAF3), Nuclear Factor-𝜅-light chain enhancer of activated B-cells …
Associations Between Reported Use Of Nutritional Labels And Calorie Intake In Us Adults: Findings From Nhanes 2017–2020, Ariana M. Chao, Nancy Greene, Alexandra Paul, Paule V. Joseph
Associations Between Reported Use Of Nutritional Labels And Calorie Intake In Us Adults: Findings From Nhanes 2017–2020, Ariana M. Chao, Nancy Greene, Alexandra Paul, Paule V. Joseph
College of Nursing Faculty Papers & Presentations
Objective: Caloric information is commonly displayed on nutritional fact labels and food menus. Yet evidence is limited on whether label use is associated with a reduced-calorie diet. This study examined the associations between the use of caloric information on nutritional facts and menu labels and daily caloric intake. Methods: We used data from adults in the National Health and Nutrition Examination Survey (NHANES) 2017–2020 to conduct a cross-sectional study. Calorie label use on nutritional labels and menus was assessed using the Flexible Consumer Behavior Survey telephone interview. Caloric intake was evaluated using the mean of two 24-h diet recalls implemented …
A Retrospective Analysis Of Taxane-Based Chemotherapy In Small Bowel Adenocarcinoma, Mir Lim, Nikhil Grandhi, Preksha Shah, Kanwal Raghav, Victoria Serpas, Maria Pia Morelli, Katrina Pedersen, Aparna Kalyan, Mohamed Salem, Ryan Huey, John Paul Shen, Huamin Wang, Hua Wang, Anjali Vinocha, Jane Thomas, Robert Wolff, Michael J Overman
A Retrospective Analysis Of Taxane-Based Chemotherapy In Small Bowel Adenocarcinoma, Mir Lim, Nikhil Grandhi, Preksha Shah, Kanwal Raghav, Victoria Serpas, Maria Pia Morelli, Katrina Pedersen, Aparna Kalyan, Mohamed Salem, Ryan Huey, John Paul Shen, Huamin Wang, Hua Wang, Anjali Vinocha, Jane Thomas, Robert Wolff, Michael J Overman
Faculty, Staff and Student Publications
Background: Small bowel adenocarcinoma (SBA) is molecularly distinct from colorectal and gastric cancers, yet treatment typically parallels colorectal cancer. We evaluated the activity of taxane-based therapy in the largest SBA cohort to date.
Methods: We retrospectively reviewed SBA patients treated with taxane-based chemotherapy at MD Anderson Cancer Center from 1994-2024. Eligible patients had pathologic confirmation, received >1 treatment cycle, and had tumor response evaluation. Survival analyses were analyzed using Kaplan-Meier and Cox proportional hazard models.
Results: Seventy patients were identified. Median age was 57, and 59% were male. Primary sites were duodenum (44%), jejunum (34%), and Ileum (16%). Metastatic sites …
Key Elements Of Mission-Based Urban Agriculture In The United States Aimed At Addressing The Social Determinants Of Health, Jordan Losavio
Key Elements Of Mission-Based Urban Agriculture In The United States Aimed At Addressing The Social Determinants Of Health, Jordan Losavio
LSU Doctoral Dissertations
Urban agriculture (UA) in the United States (U.S.) is increasingly positioned as a multi-domain strategy for addressing social determinants of health (SDOH), yet evidence is fragmented and often focused on participant outcomes rather than the organizational and environmental conditions that determine whether those benefits can be sustained, expanded, or maintained over time. This dissertation uses an exploratory sequential mixed-methods design to clarify (1) what SDOH outcomes are associated with UA in the peer-reviewed literature, (2) which internal and external factors leaders perceive as driving UA organizational success or failure, and (3) which factors predict comparative organizational functioning across a national …
Contribution Of G4 Structure To Alzheimer’S Disease And Tau Pathology, Lena Michaela Kallweit
Contribution Of G4 Structure To Alzheimer’S Disease And Tau Pathology, Lena Michaela Kallweit
Electronic Theses and Dissertations
The occurrence of Alzheimer’s Disease (AD) is rapidly increasing as our global population ages. With the majority of therapeutic drugs in the last couple of decades failing clinical trials, new molecular targets are needed to combat the expected influx of new AD cases. AD pathogenesis is associated with abnormal protein aggregation, characterized in part by intracellular accumulation of hyperphosphorylated tau (p-tau) in neurofibrillary tangles (NFTs). RNA has been identified as a major non-proteinaceous component of NFTs and has been implicated as an active cofactor in tau aggregation and spread. Recent work has shown that aggregates from AD brains contain almost …
The Impact Of Michi-No-Eki (Roadside Stations) On The Regional Economy: An Input–Output Analysis Of Minamiboso City In Chiba Prefecture, Ryusaku Matsuo, Takeru Aizawa, Gon Jan, Wei Yuanxin, Masaharu Uchiyama, Gento Tagami
The Impact Of Michi-No-Eki (Roadside Stations) On The Regional Economy: An Input–Output Analysis Of Minamiboso City In Chiba Prefecture, Ryusaku Matsuo, Takeru Aizawa, Gon Jan, Wei Yuanxin, Masaharu Uchiyama, Gento Tagami
Japanese Society and Culture
This study quantitatively examines the economic impact of Michi-no-Eki (Roadside Stations) in Minamiboso City, Chiba Prefecture, using an input–output analysis based on the Chiba Prefectural Interindustry Table. Eight Michi-no-Eki were evaluated in terms of direct, indirect, and induced effects, including employment creation. The results show that the total production-inducing effect generated by the stations amounts to ¥7.02 billion per year, and the employment-inducing effect reaches 108.7 persons annually, indicating that Michi-no-Eki function as a central engine of the local economy. Moreover, thematic diversity among stations—such as loquat, flowers, and seafood—enhances multiplier effects through inter-sectoral linkages. These findings demonstrate that Michi-no-Eki …
Fire Scarring Does Not Significantly Impact Conifer Growth Response To Forest Fires In Utah, Connor B. Biser, Russell Torgersen, Otto Degroff, Steve Petersen
Fire Scarring Does Not Significantly Impact Conifer Growth Response To Forest Fires In Utah, Connor B. Biser, Russell Torgersen, Otto Degroff, Steve Petersen
Student Works
BYU Wildfire Symposium 2026 - First Place Research Application, People's Choice Award
Wildfires are an increasingly prevalent disturbance in forests in the western United States, and play an essential role in ecosystem function. Micro-variations in fire dynamics and intensity can leave individual trees with varying levels of damage. We hypothesized that trees with fire-scars would suffer a growth depression directly following the disturbance. Core samples were taken for dendrochronological analysis from 185 conifers at 29 points, representing 11 fires from 6 years. Our findings showed a growth depression in the first year following the fire, with no significant difference between …
Immunoregulatory Effects Of Choerospondias Axillaris (Roxb.) B.L.Burtt & A.W.Hill Fruit Extract In Mice With Insights On In Vitro Mechanism, Ravi Gautam, Anju Maharjan, Jaehee Lee, Sujeong Yang, Jihun Jo, Manju Acharya, Daeun Lee, Narayan Prasad Ghimire, Saroj Lamichhane, Byungsun Min, Changyul Kim, Hyoungah Kim, Yong Heo
Immunoregulatory Effects Of Choerospondias Axillaris (Roxb.) B.L.Burtt & A.W.Hill Fruit Extract In Mice With Insights On In Vitro Mechanism, Ravi Gautam, Anju Maharjan, Jaehee Lee, Sujeong Yang, Jihun Jo, Manju Acharya, Daeun Lee, Narayan Prasad Ghimire, Saroj Lamichhane, Byungsun Min, Changyul Kim, Hyoungah Kim, Yong Heo
Department of Microbiology and Immunology Faculty Papers
BACKGROUND: Lapsi (Choerospondias axillaris), a plant native to Nepal, has been traditionally used in Asian countries to treat cardiovascular conditions. However, its effects on immune regulatory function remain largely unexplored. This study aimed to in vivo evaluate the immunoregulatory properties of Lapsi fruit extract in mice on immunotoxic responses with analysis on in vitro mechanism for immune suppression, oxidative stress, and inflammatory response. Male Balb/c mice were intragastrically administered various doses of the extract for 21 days. In some mice, immune suppression was induced with cyclophosphamide, and subsequent immune recovery was assessed. In addition, RAW264.7 cells and THP-1-derived macrophages were …
Evaluating Eight Smoking Metrics For Modelling Survival In Non-Small Cell Lung Cancer, Andrew Cl Lam, Yao Li, M Catherine Brown, Yangqing Deng, Katrina Hueniken, Natasha B Leighl, Frances A Shepherd, Kiera Murison, Zhichao Wang, Jui Kothari, Angela S Wenzlaff, Haoran Liu, Takashi Kohno, Angela Cecilia Pesatori, Curtis Harris, Hongxia Ma, Juncheng Dai, Matthew J Barnett, Ryan Diver, Leticia Ferro Leal, Guillermo Fernandez-Tardon, Mónica Pérez-Ríos, Michael Pa Davies, Bernd Holleczek, Paul Brennan, David Zaridze, Ivana Holcatova, Jolanta Lissowska, Beata Świątkowska, Dana Mates, Milan Savic, Hermann Brenner, Angeline S Andrew, Fiona Taylor, John K Field, Alberto Ruano-Ravina, Sanjay S Shete, Adonina Tardon, Ying Wang, Loic Le Marchand, Rui Manuel Reis, Matthew B Schabath, Marian L Neuhouser, Hongbing Shen, Maria Teresa Landi, Kouya Shiraishi, Jie Zhang, Ann G Schwartz, Ming S Tsao, David C Christiani, Ping Yang, Rayjean J Hung, Wei Xu, Geoffrey Liu
Evaluating Eight Smoking Metrics For Modelling Survival In Non-Small Cell Lung Cancer, Andrew Cl Lam, Yao Li, M Catherine Brown, Yangqing Deng, Katrina Hueniken, Natasha B Leighl, Frances A Shepherd, Kiera Murison, Zhichao Wang, Jui Kothari, Angela S Wenzlaff, Haoran Liu, Takashi Kohno, Angela Cecilia Pesatori, Curtis Harris, Hongxia Ma, Juncheng Dai, Matthew J Barnett, Ryan Diver, Leticia Ferro Leal, Guillermo Fernandez-Tardon, Mónica Pérez-Ríos, Michael Pa Davies, Bernd Holleczek, Paul Brennan, David Zaridze, Ivana Holcatova, Jolanta Lissowska, Beata Świątkowska, Dana Mates, Milan Savic, Hermann Brenner, Angeline S Andrew, Fiona Taylor, John K Field, Alberto Ruano-Ravina, Sanjay S Shete, Adonina Tardon, Ying Wang, Loic Le Marchand, Rui Manuel Reis, Matthew B Schabath, Marian L Neuhouser, Hongbing Shen, Maria Teresa Landi, Kouya Shiraishi, Jie Zhang, Ann G Schwartz, Ming S Tsao, David C Christiani, Ping Yang, Rayjean J Hung, Wei Xu, Geoffrey Liu
Faculty, Staff and Student Publications
Introduction: Smoking is a strong modifiable prognostic factor for lung cancer survival. We compared eight smoking metrics to determine which metric best models the relationship between smoking exposure with overall survival (OS) and lung cancer-specific survival (LCSS). These metrics included cigarettes-per-day, smoking duration, pack-years, square-root pack-years, logcig-years, the comprehensive smoking index, age-of-initiation, and years-since-quit.
Materials/methods: This retrospective, pooled analysis included 25 International Lung Cancer Consortium studies between June 1, 1983-December 31, 2019. The performance of smoking metrics for modelling OS was compared based on 1) strength and significance in adjusted Cox-proportional hazard models and 2) linearity based on the goodness-of-fit …
Transitioning From The Consolidated Framework For Implementation Research (Cfir) To The Updated Cfir For Quantitative Measurement Of Influences On Implementation Outcomes In A Faith-Based Walking Intervention, Ruth P. Saunders, Sarah Wilcox Phd, A. Caroline Rudisill, Andrew T. Kaczynski, Jasmin Parker-Brown
Transitioning From The Consolidated Framework For Implementation Research (Cfir) To The Updated Cfir For Quantitative Measurement Of Influences On Implementation Outcomes In A Faith-Based Walking Intervention, Ruth P. Saunders, Sarah Wilcox Phd, A. Caroline Rudisill, Andrew T. Kaczynski, Jasmin Parker-Brown
Faculty Publications
Background Our research team has used the highly cited Consolidated Framework for Implementation Research (CFIR) a priori throughout the research process to better understand influences on implementation outcomes of an organizational change innovation to promote physical activity and healthy eating in faith-based settings. CFIR has recently been updated to include substantial changes in some domains and constructs, and our research team is preparing to carry out a new implementation study of an evidence-based innovation in churches. The purpose of this paper is to describe the process we undertook to map CFIR domains, constructs, and quantitative measures from our earlier studies …
Nonnative Crayfish In Türkiye: Presence Records, Invasion Pathways, And Ecological Risks, Muzaffer Mustafa Harlioğlu
Nonnative Crayfish In Türkiye: Presence Records, Invasion Pathways, And Ecological Risks, Muzaffer Mustafa Harlioğlu
Turkish Journal of Zoology
The globalization of trade, aquaculture, and the ornamental pet industry has accelerated the transboundary movement of nonnative crayfish species, with significant ecological consequences. Türkiye, a biodiversity-rich country bridging Europe and Asia, has increasingly become a point of concern due to the rising presence of alien crayfish taxa introduced primarily via the aquarium trade and scientific research. This study investigates the presence records of nonnative crayfish species in Türkiye, identifies their likely introduction pathways, and outlines potential future outspread routes across the major freshwater basins of the country. Species such as Procambarus clarkii, Cherax quadricarinatus, C. albertisii, and Cambarellus patzcuarensis have …
Morphometric And Reproductive Divergence Of Deep-Water Shrimps Plesionika Martia (A. Milne-Edwards, 1883) And P. Heterocarpus (A. Costa, 1871) Along A Depth Gradient In The Eastern Aegean Sea, Murat Özbek, Cengi̇z Koçak, Zafer Tosunoğlu
Morphometric And Reproductive Divergence Of Deep-Water Shrimps Plesionika Martia (A. Milne-Edwards, 1883) And P. Heterocarpus (A. Costa, 1871) Along A Depth Gradient In The Eastern Aegean Sea, Murat Özbek, Cengi̇z Koçak, Zafer Tosunoğlu
Turkish Journal of Zoology
This study provides a comparative analysis of two deep-water pandalid shrimp species, Plesionika martia and P. heterocarpus, based on monthly samples collected over one year in the Eastern Aegean Sea. Specimens were obtained from species-specific depth zones (550 m for P. martia and 350 m for P. heterocarpus) to examine morphometric traits, sexual dimorphism, and reproductive patterns. A total of 4419 individuals were analyzed. Females were significantly larger and more abundant than males (K–S test, p < 0.05), indicating pronounced sexual dimorphism. Length–weight relationships revealed negative allometric growth in both species, confirmed by t-tests (p < 0.05). Reproductive activity differed markedly: P. martia showed a short and distinct spawning period peaking in late autumn, whereas P. heterocarpus displayed a prolonged, bimodal cycle with peaks in spring and summer. The gonadosomatic index (GSI) and the proportion of ovigerous females varied significantly by season and species. A strong positive correlation between carapace length and gonad weight was found, with a more linear relationship in P. martia and greater variability in P. heterocarpus. Size at first maturity (L₅₀) was estimated at 22.3 mm CL for P. heterocarpus but could not be reliably determined for P. martia due to limited small size data, likely reflecting ontogenetic depth segregation. The consistent bathymetric separation between these species—also reported in the Western Mediterranean—suggests ecological niche differentiation. Species-specific management measures, including depth-based fishing restrictions and temporal closures during reproductive peaks, are recommended to support the sustainable exploitation of deep sea shrimp stocks in the region.
Species Identification Using Otolith Morphometry Of Four Gurnards (Family: Triglidae) From Edremit Bay (Aegean Sea), Ahmet Mert Şenbahar, Di̇lek İlhan, Aydin Ünlüoğlu, Sencer Akalin
Species Identification Using Otolith Morphometry Of Four Gurnards (Family: Triglidae) From Edremit Bay (Aegean Sea), Ahmet Mert Şenbahar, Di̇lek İlhan, Aydin Ünlüoğlu, Sencer Akalin
Turkish Journal of Zoology
Shape and size analyses of otoliths are widely considered appropriate tools for distinguishing between fish species and for assessing populations and stocks. The present study aims to distinguish four gurnard species collected from Edremit Bay (Aegean Sea) based on variations in their otolith shape morphology. A total of 60 specimens of Eutrigla gurnardus, 64 of Chelidonichthys lastoviza, 60 of Chelidonichthys lucerna, and 60 of Lepidotrigla cavillone were analyzed. No significant intraspecific differences were noted in the morphology of the left and right otoliths, and so only the left sagittal otoliths were subjected to further analysis. Otolith shape was quantified using …
Latest Sightings Of The Striped Hyena In North Africa: Major Threats And Conservation Actions, Abderrazak El Alami, Abderrazzak Fattah, Ilyas El Alami, Ziad El Alami
Latest Sightings Of The Striped Hyena In North Africa: Major Threats And Conservation Actions, Abderrazak El Alami, Abderrazzak Fattah, Ilyas El Alami, Ziad El Alami
Turkish Journal of Zoology
The striped hyena (Hyaena hyaena) is widely distributed across the northern half of Africa, the Middle East, the Arabian Peninsula, and parts of Asia. However, numerous studies indicate that this carnivore is in decline, and it is currently classified as near threatened on the IUCN Red List of threatened species. In North Africa, the Hyaena hyaena barbara subspecies has been extirpated from many areas. This article summarizes data collected from observations of the striped hyena in North Africa between 2004 and 2024. Among the 418 striped hyenas recorded in North Africa between 2004 and 2024, 18.4% (n = 77) were …
Genetic Variants And Molecular Components Associated With Metabolic Dysfunctional-Associated Steatotic Liver Disease And Depression: Shared Association Of Adamts7 And Thrap3, Eron G. Manusov, Vincent P. Diego, Marcio A. Almeida, Jacob A. Galan, Kathryn Herklotz, Edwardo Abrego Ii, Habiba Sultana, Luis A. Peña Marquez, Marco Arriaga, Marcelo Leandro, Juan M. Peralta, Ana C. Leandro, Tom Howard, Joanne Curran, Sandra Laston, John Blangero, Sarah Williams-Blangero
Genetic Variants And Molecular Components Associated With Metabolic Dysfunctional-Associated Steatotic Liver Disease And Depression: Shared Association Of Adamts7 And Thrap3, Eron G. Manusov, Vincent P. Diego, Marcio A. Almeida, Jacob A. Galan, Kathryn Herklotz, Edwardo Abrego Ii, Habiba Sultana, Luis A. Peña Marquez, Marco Arriaga, Marcelo Leandro, Juan M. Peralta, Ana C. Leandro, Tom Howard, Joanne Curran, Sandra Laston, John Blangero, Sarah Williams-Blangero
Human Genetics Publications
Background: Metabolic dysfunction-associated steatotic liver disease (MASLD) and depression frequently occur together. Identifying the genes that influence both MASLD and depression may facilitate the discovery of biological pathways associated with disease risk.
Methods: We recruited 525 participants from Mexican American families living in the Rio Grande Valley of south Texas. We collected clinical data, biometric measurements, hepatic health assessments using Vibration-Controlled Transient Elastography (VCTE), and depression evaluations determined with the Beck Depression Inventory-II. We estimated the heritability (h2) of MASLD-related measures, depression status, aspartate aminotransferase (AST), alanine aminotransferase (ALT), the AST/ALT ratio, and Vibration-Controlled Transient Elastography measurements. For each gene, …
Primary School Physical Activity Culture In The Uk: Findings From A Four-Month Rapid Ethnography In Three Schools, Robert Walker, Lydia Emm-Collison, Danielle House, Simoona Kent-Saisch, Ruth Salway, Alice Porter, Abi Howard, Tom Reid, Michael Beets Med, Mph, Phd, Frank De Vocht, Russell Jago
Primary School Physical Activity Culture In The Uk: Findings From A Four-Month Rapid Ethnography In Three Schools, Robert Walker, Lydia Emm-Collison, Danielle House, Simoona Kent-Saisch, Ruth Salway, Alice Porter, Abi Howard, Tom Reid, Michael Beets Med, Mph, Phd, Frank De Vocht, Russell Jago
Faculty Publications
Introduction: Physical activity is fundamental for children’s health and well-being, yet most children are not active enough. School-based interventions aiming to increase children’s physical activity have largely been ineffective, perhaps due to a lack of consideration of the unique culture within each school. The aim of this paper is to understand the key aspects of physical activity culture in English primary schools using the organizational culture framework.
Methods: A four-month rapid ethnography study was conducted within three primary schools in Bristol, UK, between March and July 2024. The findings draw on observations, interviews, documentary data, photo elicitation, informal conversations and …