Open Access. Powered by Scholars. Published by Universities.®
- Institution
-
- The Texas Medical Center Library (4777)
- Brigham Young University (2470)
- City University of New York (CUNY) (2381)
- University of Nebraska - Lincoln (1837)
- University of Nevada, Las Vegas (1596)
-
- University of South Florida (1437)
- University of Texas at Arlington (1372)
- Colby College (1366)
- TÜBİTAK (1363)
- California State University, Monterey Bay (1058)
- Washington University in St. Louis (1047)
- University of South Carolina (1040)
- North Carolina Agricultural and Technical State University (981)
- University of New Mexico (928)
- University of Central Florida (881)
- Loma Linda University (770)
- Utah State University (723)
- Portland State University (685)
- South Dakota State University (657)
- Israel Antiquities Authority (608)
- University at Albany, State University of New York (528)
- University of Arkansas, Fayetteville (488)
- Missouri University of Science and Technology (464)
- Chulalongkorn University (424)
- Western Kentucky University (412)
- University of Kentucky (381)
- Thomas Jefferson University (369)
- Louisiana State University (210)
- Central Washington University (209)
- University of Texas at Tyler (204)
- Keyword
-
- Humans (2992)
- Agricultural newspapers (1346)
- American newspapers (1346)
- Central Maine (1346)
- Maine history (1346)
-
- Popular literature (1346)
- Female (1240)
- Animals (1229)
- 19th century newspapers (1200)
- Male (1065)
- Agriculture (1057)
- Mice (857)
- Natural resources (663)
- Cultural resources (638)
- Historical resources (635)
- Early California maps (620)
- Land grants (608)
- Land patents (598)
- Land tenure (597)
- Adult (566)
- California ranchos (557)
- Diseños (550)
- Middle Aged (544)
- Surveys (500)
- Plats (452)
- Aged (451)
- Biology (372)
- Bird watching (330)
- Child (318)
- Tumor (277)
- Publication Year
- Publication
-
- Faculty, Staff and Student Publications (2688)
- Theses and Dissertations (2462)
- Faculty, Staff and Students Publications (1552)
- Publications and Research (1188)
- Jessie Maye Smith Birds and Watchers Columns Collection (1036)
-
- Documents (980)
- The Waterville Mail (Waterville, Maine) (939)
- Faculty Publications (905)
- Arts & Sciences Graduate Student Theses and Dissertations (884)
- Electronic Theses and Dissertations (782)
- Loma Linda University Electronic Theses, Dissertations & Projects (763)
- Marine Science Faculty Publications (727)
- Dissertations, Theses, and Capstone Projects (673)
- Dissertations and Theses (653)
- Biology ETDs (604)
- UNLV Theses, Dissertations, Professional Papers, and Capstones (597)
- 'Atiqot (560)
- Legacy Theses & Dissertations (2009 - 2024) (468)
- Turkish Journal of Veterinary & Animal Sciences (445)
- Children’s Nutrition Research Center Staff Publications (416)
- Chulalongkorn University Theses and Dissertations (Chula ETD) (410)
- The Eastern Mail (Waterville, Maine) (407)
- Turkish Journal of Zoology (363)
- SDSU Extension Circulars (350)
- USF Tampa Graduate Theses and Dissertations (329)
- Biological Sciences Faculty Research & Creative Works (268)
- Turkish Journal of Agriculture and Forestry (256)
- Honors Undergraduate Theses (222)
- Turkish Journal of Botany (189)
- Life Sciences Faculty Research (161)
- Publication Type
Articles 511 - 540 of 40156
Full-Text Articles in Entire DC Network
Synthesis Of Copper-Phenanthroline Complexes: A Solvothermal-Compatible Approach For The Exploration Of Metal Complexes, Yunping Zhoujin, Michael Anim Safo, Navindra Keerthisinghe, Mark D. Smith, Sophya Garashchuk, Hans Conrad Zur Loye
Synthesis Of Copper-Phenanthroline Complexes: A Solvothermal-Compatible Approach For The Exploration Of Metal Complexes, Yunping Zhoujin, Michael Anim Safo, Navindra Keerthisinghe, Mark D. Smith, Sophya Garashchuk, Hans Conrad Zur Loye
Faculty Publications
Inorganic–organic hybrid materials have been widely investigated for their applications in catalysis, optics, magnetism, and biomedicine. Copper halide complexes are of particular interest due to their structural diversity and physicochemical properties. Conventional crystal growth approaches, such as slow evaporation and hydro(solvo)thermal synthesis, typically require extended reaction times and often favor thermodynamically stable phases. In this study, we prepared ten copper-phenanthroline halide (X = Cl, Br, and I) complexes using both traditional hydrothermal reactions and microwave-assisted hydrothermal methods and obtained [CuI(C12H8N2)2][I3], [C12H9N2][CuI2]·(H2 …
Understanding P53 Regulation On Transposable Elements In Cancer, Xuan Qu
Understanding P53 Regulation On Transposable Elements In Cancer, Xuan Qu
Arts & Sciences Graduate Student Theses and Dissertations
Transposable elements (TEs), traditionally known as “jumping genes”, are known to have the ability to move in the genome and alter the activation of transcriptions from nearby genes. Taking up nearly half of the human genome, TEs have evolved, and some have been selected to play important roles in biological processes. We found that in human diseases such as cancer, global hypomethylation resurrects many ordinarily silenced TEs. These TEs can often serve as alternative promoters for oncogenes and play functionally meaningful roles in driving disease processes. One of the top genetic mutation status that correlates with differential numbers of TE …
Dietary Influence And Neurodegenerative Disease Risk: Insight From Alzheimer’S And Parkinson’S Disease, Madison Wirt
Dietary Influence And Neurodegenerative Disease Risk: Insight From Alzheimer’S And Parkinson’S Disease, Madison Wirt
Honors Projects
As populations age, neurodegenerative diseases (NDD) become significantly more prevalent and impactful on patients and families. Clinical research has suggested a correlation between diet, gut health, neuroinflammation and mitochondrial dysfunction to the onset and development of specific and severe NDDs, especially Alzheimer’s disease (AD) and Parkinson’s disease (PD). This research focuses on the relationship behind the gut-brain axis, micronutrient status and how diet influences the development of both AD and PD. Ten randomized, controlled trials were analyzed from the literature to investigate the impact of these factors on the inflammatory, metabolic and antioxidant processes. The studies focused on the use …
Lingnan Gardeners Newsletter (No. 78) = 彩園通訊 (第78期), Lingnan Gardeners, Centre For Cultural Research And Development, Lingnan University
Lingnan Gardeners Newsletter (No. 78) = 彩園通訊 (第78期), Lingnan Gardeners, Centre For Cultural Research And Development, Lingnan University
Lingnan Gardeners Newsletter 嶺南彩園通訊
No abstract provided.
Abundance Of Microplastics In The Water And Stream Fish Of Big Walnut Creek, David J. Hartman
Abundance Of Microplastics In The Water And Stream Fish Of Big Walnut Creek, David J. Hartman
Undergraduate Honors Thesis Projects
Microplastics are a major threat to both ecosystem and human health. In this study, I investigated the abundance of microplastics at five sites along Big Walnut Creek, Ohio including sites upstream, downstream, and within urban development. Samples were taken from the stream surface water and fish at each site. Microplastics were detected in the surface water and fish at all five sites with a total of 383 microplastic particles found in the 157 fish collected for this study. The mean concentration for all sites was 80.8 particles/m3 in the surface water and 2.4 particles per fish. Microplastics were almost entirely …
Bird Population Response To Abiotic And Biotic Stresses In Urban & Restored Oak Savannah Habitat, Annabelle Ball
Bird Population Response To Abiotic And Biotic Stresses In Urban & Restored Oak Savannah Habitat, Annabelle Ball
Posters - 2026
Birds are heavily impacted by urban development. Many experience habitat fragmentation and removal of food sources. However, other species can adapt to and even thrive in urban environments, thanks to certain tree species, bird feeders, and buildings. In North America, the house sparrow and the European starling are invasive species that benefit from urban environments (Bartelt, 2011; Fitzwater, 2014). Meanwhile, many habitats across the continent are experiencing restoration/rewilding efforts for the benefit of birds. One such habitat is the oak-savannah, which is characterized by 10-30% canopy cover and a mixture of prairie & woodland vegetation, supporting a high diversity of …
Exploratory Evaluation Of Handler Performance And Processing-Related Outcomes During Cattle Handling, Morgan Marquardt
Exploratory Evaluation Of Handler Performance And Processing-Related Outcomes During Cattle Handling, Morgan Marquardt
Department of Animal Science: Dissertations, Theses, and Student Research
Animals have several critical roles in society, including the production of food and fiber, and companionship. Contact with animals has been shown to benefit human physical and mental health, yet little research has investigated the impact that humans have on animals. Handler skill may considerably affect the extent to which humans influence animal health and wellbeing, and this may be a critical consideration for animal agriculture. Objective assessment of cattle handler skill has received limited attention in the scientific literature, despite its importance to human safety and animal welfare. When compared to less skilled handlers, highly skilled cattle handlers may …
Global Epidemiology Of Cephalopina Titillator Infestation In Camels: A Systematic Review And Meta-Analysis (1980–2025), Temesgen Mohammed, Aboma Zewude, Tsegaye Shamebo, Layaly Hamdan, Atef Oreiby, Hazim O. Khalifa, Gobena Ameni, Bojan Gajic
Global Epidemiology Of Cephalopina Titillator Infestation In Camels: A Systematic Review And Meta-Analysis (1980–2025), Temesgen Mohammed, Aboma Zewude, Tsegaye Shamebo, Layaly Hamdan, Atef Oreiby, Hazim O. Khalifa, Gobena Ameni, Bojan Gajic
All Works
Background – Cephalopina titillator (C. titillator) is the causative agent of camel nasopharyngeal myiasis and is widespread in camel-rearing regions worldwide, causing impaired health, reduced productivity, and economic losses. However, despite the veterinary importance of C. titillator, global epidemiological evidence remains limited and fragmented, and no comprehensive synthesis of prevalence data across camel-rearing regions has previously been conducted. The objective of this review was to estimate the global pooled prevalence of C. titillator infestation in camels. In addition, subgroup analyses were made to assess the effect of camel species, geographic region, and study period on the pooled prevalence of C. …
All-Cause And Cause-Specific Mortality In Patients With Bipolar Ii Disorder, Chih-Wei Hsu, Yang-Chieh Brian Chen, Edward Chia-Cheng Lai, Andrew A Nierenberg, Michael Berk, Sheng-Yu Lee, Liang-Jen Wang, Mu-Hong Chen, Yao-Hsu Yang, Chih-Sung Liang, Andre F Carvalho
All-Cause And Cause-Specific Mortality In Patients With Bipolar Ii Disorder, Chih-Wei Hsu, Yang-Chieh Brian Chen, Edward Chia-Cheng Lai, Andrew A Nierenberg, Michael Berk, Sheng-Yu Lee, Liang-Jen Wang, Mu-Hong Chen, Yao-Hsu Yang, Chih-Sung Liang, Andre F Carvalho
Children’s Nutrition Research Center Staff Publications
Importance: Whether bipolar II disorder (BD-II) is associated with increased long-term mortality remains uncertain because most studies have not distinguished BD-II from bipolar I disorder (BD-I).
Objective: To examine whether BD-II is associated with elevated all-cause and cause-specific mortality compared with population controls, unaffected siblings, and those with BD-I.
Design, setting, and participants: This population-based, retrospective cohort study used data from Taiwan's National Health Insurance Database from January 1, 2000, to December 31, 2022. Individuals 12 years or older with 2 or more psychiatrist-assigned BD-II diagnoses were individually matched to 4 controls without BD-II by sex and birthdate. Additional comparisons …
The “One Big Beautiful Bill” Will Deepen The Farm Crisis, Not Solve It, Rebecca Schewe, Rick Welsh
The “One Big Beautiful Bill” Will Deepen The Farm Crisis, Not Solve It, Rebecca Schewe, Rick Welsh
Center for Policy Research
The One Big Beautiful Bill (OBBB) promises billions in new farm subsidies, but most of that money won’t go to the farmers who need it most. This brief describes how the OBBB’s changes to agricultural subsidy programs will disproportionately benefit large farms and non-farming investors, accelerating farm loss and consolidation across the United States. The authors argue that without reforms, the OBBB will inflate land values, raise barriers for new and small farmers, and further fuel absentee farmland investment. The authors also identify four reforms policymakers should enact to prevent these devastating consequences, including tightening payment limits and closing loopholes, …
Blink & Beat: Pupillometry Response In Autonomic Nervous System Monitoring, Ximena Castillo
Blink & Beat: Pupillometry Response In Autonomic Nervous System Monitoring, Ximena Castillo
2026 Spring Honors Capstones Projects
In the neuroscience intensive care unit (NSICU), nurses rely on advanced monitoring tools to detect neurological deterioration. Two noninvasive measures, heart rate variability (HRV) and pupillary light reflex (PLR), are used to assess autonomic nervous system function; however, it remains unclear whether these indicators provide overlapping or distinct information. The purpose of this observational prospective study is to evaluate the relationship between HRV and quantitative pupillometry measurements to determine whether these noninvasive indicators provide congruent information. Data already collected as routine care from NSICU patients is extracted from the medical record for analysis. Understanding the correlation between HRV and PLR …
Teeth That Tell Time: Elemental Analysis From Shark Teeth, Gisele-Elizabeth Perez, David Turner
Teeth That Tell Time: Elemental Analysis From Shark Teeth, Gisele-Elizabeth Perez, David Turner
Research Papers
Sharks (Chondrichthyes) have hunted in the oceans for over 400 million years, their teeth leaving history behind, constantly becoming a part of the fossilization process (Worm et al. 2013). Their survival throughout 5 major extinctions is due to their ability to adapt easily with slow metabolism, a wide range of diet, and an efficient physiology. Shark teeth are vital to the hunting and consumption of their prey, making it a point for scientists to study them. Their tooth minerals contain fluorapatite in their enameloid, and dentin in the “root” of the tooth, with extinct species containing dentin and hydroxyapatite in …
Teeth That Tell Time: Elemental Analysis From Shark Teeth, Gisele-Elizabeth Perez
Teeth That Tell Time: Elemental Analysis From Shark Teeth, Gisele-Elizabeth Perez
Posters - 2026
Sharks (Chondrichthyes) have hunted in the oceans for over 400 million years, their teeth leaving history behind, constantly becoming a part of the fossilization process (Worm et al. 2013). Their survival throughout 5 major extinctions is due to their ability to adapt easily with slow metabolism, a wide range of diet, and an efficient physiology. Shark teeth are vital to the hunting and consumption of their prey, making it a point for scientists to study them. Their tooth minerals contain fluorapatite in their enameloid, and dentin in the “root” of the tooth, with extinct species containing dentin and hydroxyapatite in …
Glioblastoma Multiforme: A Pathologic Breakdown Of One Of Neuro-Oncology's Greatest Challenges, Rosemary Westphal, Ms
Glioblastoma Multiforme: A Pathologic Breakdown Of One Of Neuro-Oncology's Greatest Challenges, Rosemary Westphal, Ms
Student Papers, Posters & Projects
Glioblastoma multiforme is the most common adult primary tumor with a grim median survival time of 14.6 months. It is characterized by rapid progression, diffuse infiltration, and rather poor clinical outcomes. The WHO classifies GBM as a grade 4 diffuse astrocytic tumor with distinctive histopathological features including high mitotic activity, marked cellular atypia, microvascular proliferation, and necrosis. Advances in molecular diagnostics have further classified GMB into IDH-wild type and IDH-mutant subtypes, with important therapeutic and prognostic implications. Key genetic alterations, such as EGFR amplification, PTEN loss, TP53 mutations, TERT promoter mutations, and MGMT methylations, have been identified as contributing to …
Multiparametric Mri To Predict Response To Irreversible Electroporation Plus Anti-Pd-1 Immunotherapy In Pancreatic Ductal Adenocarcinoma, Qizhen Cao, Mark D Pagel, Charles V Kingsley, Jingfei Ma, James P Long, Xiaoxia Wen, Seth T Gammon, Jorge Delacerda, Sanaz Javadi, Chun Li
Multiparametric Mri To Predict Response To Irreversible Electroporation Plus Anti-Pd-1 Immunotherapy In Pancreatic Ductal Adenocarcinoma, Qizhen Cao, Mark D Pagel, Charles V Kingsley, Jingfei Ma, James P Long, Xiaoxia Wen, Seth T Gammon, Jorge Delacerda, Sanaz Javadi, Chun Li
Faculty, Staff and Student Publications
Purpose: To investigate contrast-enhanced T1-weighted MRI and diffusion-weighted magnetic resonance imaging (DWI) for early prediction of tumor response to combined irreversible electroporation (IRE) and anti-PD-1 immunotherapy.
Methods: Murine pancreatic ductal adenocarcinoma (PDAC) cells KRAS* were inoculated into the pancreas of C57BL/6 mice. IRE was performed when tumors became palpable. After IRE, mice received six intraperitoneal injections of anti-PD-1 over 2 weeks. T2-weighted MRI, T1-weighted MRI with macromolecular contrast agent poly(L-glutamic acid)-conjugated gadolinium (PG-Gd), and DWI were performed before and after IRE. Survival was analyzed using Kaplan-Meier curves. Mice surviving at least 100 days without recurrence after IRE were considered complete …
Gompertz Growth With A Shared Carrying Capacity Optimally Simulates Primary And Metastatic Tumor Growth Dynamics, Pirmin Schlicke, Preethi Korangath, Xiaoxi Pan, Caner Ercan, Kathleen Gabrielson, Lyndsey Werhane, Yinyin Yuan, Sébastien Benzekry, Robert Ivkov, Heiko Enderling
Gompertz Growth With A Shared Carrying Capacity Optimally Simulates Primary And Metastatic Tumor Growth Dynamics, Pirmin Schlicke, Preethi Korangath, Xiaoxi Pan, Caner Ercan, Kathleen Gabrielson, Lyndsey Werhane, Yinyin Yuan, Sébastien Benzekry, Robert Ivkov, Heiko Enderling
Faculty, Staff and Student Publications
Background: Cancer is a systemic disease with most deaths attributed to metastatic burden. Primary and metastatic tumors, albeit at different anatomic locations, are interconnected through multiple biological processes. Pre-clinical and clinical observations of growth acceleration of metastases after surgery, or abscopal effects outside the radiation field are widely reported, yet reliably triggering favorable and avoiding unfavorable systemic responses remains an unmet clinical need. Understanding local and systemic tumor interaction dynamics will help guide future treatments.
Methods: We analyze the data of multiple in vivo tumor models. We formalize the systemic interplay of tumors as mathematical differential equation and calibrate parameters …
Structural-Functional Analyses Of The Huntingtin/Hap40 Complex In Drosophila And Humans, Stephen M Farmer, Amanda Solbach, Shiyu Xu, Beatriz Rios, Xin Ye, Amy Gao, Daniela Covarrubias, Yue Yu, Lili Ye, Vicky Chuong, Erin Furr Stimming, Haiqing Zhao, Sheng Zhang
Structural-Functional Analyses Of The Huntingtin/Hap40 Complex In Drosophila And Humans, Stephen M Farmer, Amanda Solbach, Shiyu Xu, Beatriz Rios, Xin Ye, Amy Gao, Daniela Covarrubias, Yue Yu, Lili Ye, Vicky Chuong, Erin Furr Stimming, Haiqing Zhao, Sheng Zhang
Faculty, Staff and Student Publications
Huntington's disease (HD) is a neurodegenerative disorder caused by an abnormal CAG expansion in the Huntingtin (HTT) gene. Given its simple genetic cause but complex pathogenic mechanisms, interest in targeting HTT for HD treatment is growing, necessitating a clear understanding of HTT regulation. HTT protein primarily exists in a core complex with HAP40, forming a highly ordered structure with two large globular domains connected by a bridge. We previously demonstrated that HAP40 is conserved in
Unraveling The Nexus: Tumor Mutational Burden, Pd-L1 Expression, And Oncogenic Alterations In Non-Small Cell Lung Cancer Cytology Specimens, Min Dai, Francis Anthony San Lucas, Hector Alvarez, Leomar Ballester, Hui Chen, Keyur P Patel, Asif Rashid, Shun Rao, Mark J Routbort, Gloria Sura, Keith Sweeney, Gokce Toruner, Peng Wei, Richard Yang, Hyvan Dang, Rajyalakshmi Luthra, Sinchita Roy-Chowdhuri
Unraveling The Nexus: Tumor Mutational Burden, Pd-L1 Expression, And Oncogenic Alterations In Non-Small Cell Lung Cancer Cytology Specimens, Min Dai, Francis Anthony San Lucas, Hector Alvarez, Leomar Ballester, Hui Chen, Keyur P Patel, Asif Rashid, Shun Rao, Mark J Routbort, Gloria Sura, Keith Sweeney, Gokce Toruner, Peng Wei, Richard Yang, Hyvan Dang, Rajyalakshmi Luthra, Sinchita Roy-Chowdhuri
Faculty, Staff and Student Publications
Background: PD-L1 expression and tumor mutational burden (TMB) are biomarkers for immune checkpoint inhibitor (ICI) therapy in non-small cell lung cancer (NSCLC); however, patients harboring oncogenic alterations have limited benefit from ICIs. The impact of oncogenic alterations on TMB and PD-L1 tumor proportion score in lung cytology specimens is poorly understood. Herein, the association between oncogenic alterations, TMB, and PD-L1 in NSCLC cytology specimens is explored.
Methods: Next-generation sequencing results from 312 NSCLC cytology specimens were retrospectively reviewed that interrogate 610 genes and select immuno-oncology signatures. TMB and PD-L1 immunohistochemical expression across oncogenic alterations were analyzed to explore associations.
Results: …
Baseline Parp-1 Pet Imaging In Patients With Advanced Solid Tumors With Dna Damage Response Mutations, Tarek Daoud, Jiansong Chen, Peng Wei, Franklin Wong, Timothy A Yap, Lilie L Lin
Baseline Parp-1 Pet Imaging In Patients With Advanced Solid Tumors With Dna Damage Response Mutations, Tarek Daoud, Jiansong Chen, Peng Wei, Franklin Wong, Timothy A Yap, Lilie L Lin
Faculty, Staff and Student Publications
Purpose: Inhibitors of poly(ADP-ribose) polymerase (PARP), an enzyme with numerous roles in DNA damage response signaling, represent a class of anti-cancer drugs approved for treating solid tumors with defects in the DNA damage response. However, additional methods for identifying patients who would benefit from the use of PARP inhibitors are urgently needed. We evaluated a novel radiotracer, 18F-FluorThanatrace ([18F]-FTT), to noninvasively assess PARP activity with PET/CT before treatment and determine associations between uptake, tumor mutation status, and prior receipt of therapy including PARP inhibitors.
Methods: Fifty-two patients with solid tumors underwent whole-body (skull base to thigh) [18F]-FTT PET/CT scans before …
Tumor Flare Reaction With Brentuximab-Vedotin In Mycosis Fungoides, Rishabh Lohray, Seda Purnak, Samruddhi Arkatkar, Madeleine Duvic, Victor Prieto, Carlos Torres-Cabala, Auris Huen
Tumor Flare Reaction With Brentuximab-Vedotin In Mycosis Fungoides, Rishabh Lohray, Seda Purnak, Samruddhi Arkatkar, Madeleine Duvic, Victor Prieto, Carlos Torres-Cabala, Auris Huen
Faculty, Staff and Student Publications
No abstract provided.
Identifying Sorafenib Benefit Among Patients With Hepatocellular Carcinoma: A Transcriptomic And Genomic Approach, Sun Young Yim, Hayeon Kim, Tae Hyung Kim, Sang-Hee Kang, Youngwoo Lee, Eunho Choi, Yang Jae Yoo, Seong Hee Kang, Young-Sun Lee, Young Kul Jung, Yeon Seok Seo, Hyung Joon Yim, Jong Eun Yeon, Kyung Suk Yang, Yitao Tang, Bowha Sohn, Yun Seong Jeong, Hyewon Park, Han Liang, Ju-Seog Lee, Ji Hoon Kim
Identifying Sorafenib Benefit Among Patients With Hepatocellular Carcinoma: A Transcriptomic And Genomic Approach, Sun Young Yim, Hayeon Kim, Tae Hyung Kim, Sang-Hee Kang, Youngwoo Lee, Eunho Choi, Yang Jae Yoo, Seong Hee Kang, Young-Sun Lee, Young Kul Jung, Yeon Seok Seo, Hyung Joon Yim, Jong Eun Yeon, Kyung Suk Yang, Yitao Tang, Bowha Sohn, Yun Seong Jeong, Hyewon Park, Han Liang, Ju-Seog Lee, Ji Hoon Kim
Faculty, Staff and Student Publications
Background & aims: Sorafenib has been a cornerstone of hepatocellular carcinoma (HCC) therapy; however, its efficacy is limited, and identifying patients who will benefit from sorafenib is challenging. We aimed to identify predictive biomarkers of sorafenib benefit in patients with HCC.
Methods: Gene expression data from 33 HCC tumors treated with sorafenib were analyzed to construct a prediction model aimed at identifying patients with greater benefit from sorafenib treatment. The robustness of the predictor was validated using gene expression data from two phase III clinical trials, IMbrave150 and STORM.
Results: The analysis of transcriptome data revealed a 50-gene signature, the …
Just Unmasking Knowledge? A Critical Interpretation Of Fluctuating Jellyfish Populations For A Mass Media Audience, Wrenne R. Grone
Just Unmasking Knowledge? A Critical Interpretation Of Fluctuating Jellyfish Populations For A Mass Media Audience, Wrenne R. Grone
Undergraduate Honors Thesis Projects
While podcasts may not be the most popular form of mass media, they are growing in their accessibility and prevalence in educational discourse. My creative work, in the form of a podcast, unmasks scientific knowledge in an untraditional, mass-media form and will use podcast techniques, such as music transitions and storytelling techniques, to maintain engagement. Additionally, my podcast aims to transpose academic knowledge into a comprehensible, interesting form for a non-academic audience. Jellyfish have no brains, no heart, no blood, and no bones and yet, they have survived for millions of years. The goal of my podcast is to educate …
Variations In Attitudes Toward Working With Robots And Concerns About Robots Replacing Jobs Among Midwesterners, Kawsheha Muraleetharan, Julia Mcquillan, Philip G. Crandall, Corliss A. O'Bryan, Trey Fago, Jospeh Jochman
Variations In Attitudes Toward Working With Robots And Concerns About Robots Replacing Jobs Among Midwesterners, Kawsheha Muraleetharan, Julia Mcquillan, Philip G. Crandall, Corliss A. O'Bryan, Trey Fago, Jospeh Jochman
Food Science Faculty Publications and Presentations
This study examines how social and worldview factors influence public attitudes toward workplace robotics in Nebraska, a major U.S. meat-producing state where automation adoption remains comparatively slow. Using data from the 2020 Nebraska Annual Social Indicators Survey (n = 2,213), we analyzed two core outcomes: willingness to work with robots ("robot happy") and concern about job replacement ("robot concern"). Ordinary least-squares regression models revealed that women, older adults, and those with less education were less positive about working with robots, while respondents with more education, higher financial security, stronger trust in science, and liberal political orientations expressed greater acceptance. Education …
Electromyography, Prosthetic Properties, And Running Biomechanics In Recreationally Active Persons With Lower Extremity Amputation, Paige M. Agnew
Electromyography, Prosthetic Properties, And Running Biomechanics In Recreationally Active Persons With Lower Extremity Amputation, Paige M. Agnew
Rehabilitation Sciences Theses & Dissertations
Lower extremity loss affects nearly 150,000 individuals in the United States yearly yielding extreme health care costs annually. Typically, prosthetic devices are prescribed for 5-8 years despite known changes to an individual’s gait as time progresses. Patients can expect to undergo approximately 8-12 weeks of gait retraining to improve their comfort and efficiency. Biomechanical changes occur when running with a specific running prosthetic including considerable biomechanical and neuromuscular interlimb asymmetries and alterations in loading patterns. The purpose of this dissertation was to investigate the biomechanical demands for lower extremity prosthesis users during running. The first study synthesized peer reviewed evidence …
Axillary Management After Neoadjuvant Endocrine Therapy (Net), Laura Leonard, Min Yi, Emma Wingate, Puneet Singh, Abigail Caudle, Rosa F Hwang, Isabelle Bedrosian, Vicente Valero, Jennifer Litton, Nuhad Ibrahim, Kelly K Hunt
Axillary Management After Neoadjuvant Endocrine Therapy (Net), Laura Leonard, Min Yi, Emma Wingate, Puneet Singh, Abigail Caudle, Rosa F Hwang, Isabelle Bedrosian, Vicente Valero, Jennifer Litton, Nuhad Ibrahim, Kelly K Hunt
Faculty, Staff and Student Publications
BACKGROUND: In patients with hormone receptor-positive (HR
PATIENTS AND METHODS: We performed a retrospective review of patients with clinical stage I-III, HR
RESULTS: A total of 230 patients were included; 120 (52.2%) were clinically node-negative (cN0), while 110 (47.8%) were clinically node-positive (cN+). In the cN+ group, 7.3% (8/110) had a nodal pathologic complete response (pCR). In total, 76.4% (84/110) in the cN+ group underwent axillary lymph node dissection (ALND) as the initial axillary procedure, and 90.9% (100/110) underwent ALND overall. In total, 98.3% (118/120) with cN0 disease underwent sentinel lymph node dissection (SLND), and 28 (23.7%) had positive nodes. …
Neutrophil-Microglia Interaction Drives Motor Dysfunction In A Neuromyelitis Optica Model Induced By Subarachnoid Aqp4-Igg, Fangfang Qi, Vanda A Lennon, Shunyi Zhao, Yong Guo, Husheng Ding, Caiyun Liu, Whitney M Bartley, Tingjun Chen, Claudia F Lucchinetti, Long-Jun Wu
Neutrophil-Microglia Interaction Drives Motor Dysfunction In A Neuromyelitis Optica Model Induced By Subarachnoid Aqp4-Igg, Fangfang Qi, Vanda A Lennon, Shunyi Zhao, Yong Guo, Husheng Ding, Caiyun Liu, Whitney M Bartley, Tingjun Chen, Claudia F Lucchinetti, Long-Jun Wu
Faculty, Staff and Student Publications
Neutrophils and neutrophil extracellular traps (NETs) contribute to early neuromyelitis optica (NMO) histopathology initiated by IgG targeting astrocytic aquaporin-4 (AQP4) water channels. Yet, the mechanisms underlying neutrophil recruitment and their pathogenic roles in disease progression remain unclear. To investigate molecular-cellular events preceding classical complement cascade activation in a mouse NMO model, we continuously infused, via spinal subarachnoid route, a non-complement-activating mouse monoclonal AQP4-IgG. Parenchymal infiltration of netting neutrophils containing C5a ensued with microglial activation and motor impairment but no blood-brain barrier leakage. Motor impairment and neuronal dysfunction both reversed when AQP4-IgG infusion stopped. Two-photon microscopy and electron microscopy-based reconstructions revealed …
Dendrimer Nanogels With Built-In Free Radical Scavenging Enable Efficient Topical Delivery Of A Hydrophilic Antioxidant To Restore Lens Redox Balance For Cataract Treatment, Lin Qi, Huari Kou, Anna Chernatynskaya, Da Huang, Vimalin Jeyalatha Mani, Humeyra Karacal, Nuran Ercal, Hu Yang
Dendrimer Nanogels With Built-In Free Radical Scavenging Enable Efficient Topical Delivery Of A Hydrophilic Antioxidant To Restore Lens Redox Balance For Cataract Treatment, Lin Qi, Huari Kou, Anna Chernatynskaya, Da Huang, Vimalin Jeyalatha Mani, Humeyra Karacal, Nuran Ercal, Hu Yang
Chemistry Faculty Research & Creative Works
Cataract is a leading cause of vision impairment worldwide and are primarily caused by oxidative stress that damages and aggregates lens proteins, leading to lens opacification. However, the eye's anatomical barriers limit the penetration and bioavailability of antioxidant therapies. To address this challenge, a dendrimer-based nanogel with a built-in reactive oxygen species (ROS)-scavenging capability developed by us was employed to deliver the antioxidant N-acetylcysteine (NAC) to the lens. NAC was loaded into a generation-5 PEGylated poly(amidoamine) dendrimer (G5-PEG-TK, termed the GPT) nanogel. The resulting NAC-GPT was characterized for its ROS-scavenging activity, bioavailability, and corneal permeability. The efficacy of NAC-GPT was …
Weaning Drives Microbiome-Mediated Epigenetic Regulation To Shape Immune Memory In Mice, Li Yang, Robert C Peery, Shirui Zhou, Xiaomin Chen, Leah M Farmer, Fabiola Gutierrez, Stephanie Fowler, Lanjing Zhang, Julia M Salamat, Karen Riggins, Jiejun Shi, Lanlan Shen
Weaning Drives Microbiome-Mediated Epigenetic Regulation To Shape Immune Memory In Mice, Li Yang, Robert C Peery, Shirui Zhou, Xiaomin Chen, Leah M Farmer, Fabiola Gutierrez, Stephanie Fowler, Lanjing Zhang, Julia M Salamat, Karen Riggins, Jiejun Shi, Lanlan Shen
Children’s Nutrition Research Center Staff Publications
During weaning, the transition to solid food diversifies the gut microbiome, triggering a programmed immune response critical for long-lasting mucosal immunity. Previous work showed that the gut microbiome mediates epigenetic development in intestinal stem cells (ISCs) during suckling, but what happens during weaning is unclear. Here, genome-wide profiling revealed that weaning-driven microbiome changes shape the DNA methylome and transcriptome of murine ISCs in an IFNγ-dependent manner. Specifically, we observe demethylation of enhancer elements essential for MHC class II genes, which results in a transcriptional memory that persists through differentiation into adulthood. IFNγ blockade, or low-dose penicillin to target Gram-positive bacteria, …
Perspective In Biomedical Sciences Field: Education And Career, Fitra Adi Prayogo, Mellyaning Oktaviani Sonya Kirana Sari, Isy Royhanaty, Poppy Fansisca Amelia, Heni Wijayanti, Ni Nyoman Maryaningtyas Adinatha, Dyah Wulandari, Anto Budiharjo
Perspective In Biomedical Sciences Field: Education And Career, Fitra Adi Prayogo, Mellyaning Oktaviani Sonya Kirana Sari, Isy Royhanaty, Poppy Fansisca Amelia, Heni Wijayanti, Ni Nyoman Maryaningtyas Adinatha, Dyah Wulandari, Anto Budiharjo
Chulalongkorn Medical Journal
Abstract
Background: The biomedical sciences represent a dynamic and multidisciplinary field pivotal to advancing human health through research, education, and innovation.
Objective(s): This review explores the evolving landscape of biomedical education and career pathways, driven by technological advancements, interdisciplinary integration, and global health demands.
Methods: We examine the distinctions between biomedical science, biomedicine, and biomedical engineering, highlighting their historical origins and contemporary roles. The education and career trajectories of biomedical laboratory scientists (BLS) are analysed, emphasising diverse competencies, core curricula, and the impact of regional policies on professional qualifications. Emerging trends and ethical/regulatory challenges are discussed.
Result(s): Key trends include …
Suture Augmentation With Ucl Repairs In Baseball Pitchers As An Alternate To Reconstructions: An Evidence-To-Practice Review, Kayleigh A. De Koker, Kenneth E. Games
Suture Augmentation With Ucl Repairs In Baseball Pitchers As An Alternate To Reconstructions: An Evidence-To-Practice Review, Kayleigh A. De Koker, Kenneth E. Games
Clinical Practice in Athletic Training
An injury to the ulnar collateral ligament (UCL) is sustained through repetitive valgus motions, increasing in prevalence across all levels of baseball due to the increasing workload demands placed on the medial elbow in pitching. Traditionally, UCL tears have been managed through reconstructions followed by a lengthy rehabilitation process. In recent years, the UCL repair with suture augmentation has gained favor given the enhanced patient and clinician outcomes in return-to-play timelines, decreased medial gapping, improved Kerlan Jobe Orthopedic Clinic (KJOC) scores, and long-term functionality. Utilizing 4 databases (MEDLINE, Embase Cochrane library, Science Direct, and Scopus), literature was obtained addressing the …