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Atomoxetine Enhances Specific Dimensions Of Cognitive Performance In A Rodent Strategy Shifting Assay, Jessica Ivanov

Rowan-Virtua Research Day

Title: Atomoxetine enhances specific dimensions of cognitive performance in a rodent strategy shifting assay

Authors: Jessica Ivanov, Christopher P. Knapp, Barry D. Waterhouse, Rachel L. Navarra

Objective: Cognitive flexibility, a domain of executive function, supports adaptive shifts in behavior in response to changing environmental demands and task contingencies. Deficits in this capacity are common to neuropsychiatric disorders such as Attention Deficit Hyperactivity Disorder (ADHD), where improper regulation of the catecholamine transmitters dopamine (DA) and norepinephrine (NE) within the prefrontal cortex (PFC) has been implicated. Atomoxetine (ATX), a selective NE transporter (NET) inhibitor, elevates levels of NE and DA in the …

Optimization Of Refolding, Purification, And Analytical Characterization Of Proinsulin(F25d) Soluble Antigen Array Immunotherapy, Abigail Richardson

McKelvey School of Engineering Graduate Student Theses & Dissertations

Type 1 Diabetes (T1D) is characterized by autoreactive immune responses to insulin and its precursor, proinsulin. Soluble antigen arrays (SAgAs) displaying the metabolically inactive proinsulin variant, proinsulin(F25D), represent a promising antigen‑specific immunotherapy candidate for T1D. However, the production of these platforms is hindered by substantial practical challenges, including protein aggregation, inefficient refolding, and the lack of sensitive analytical tools to verify quality and dosage. This work establishes an integrated, scalable pipeline for the purification, conjugation, and quantification of a proinsulin(F25D) SAgA. First, we optimized the refolding of recombinant methionine-proinsulin(F25D) (M-PI(F25D)) from inclusion bodies using controlled buffer systems and created a …

Effect Of Accelerated Adaptation Programs On Feedlot Performance And Health Of Steers Drenched With Megasphaera Elsdenii And Quantifying And Partitioning Multi-Year Carbon Dioxide And Methane Fluxes In A Grazed Temperate Pasture, Rebecca Mcdermott

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

With strong consumer demand for beef and increasing concern about the environmental impacts of beef production, improving production efficiency and advancing the understanding of the environmental footprint are critical for the long-term sustainability of beef production systems. The first experiment evaluated the effect of accelerated adaptation strategies, using energy intake and cattle behavior, on feedlot performance, carcass characteristics, and health of yearling steers drenched with exogenous Megasphaera elsdenii. Accelerated adaptation programs (0, 7, or 14 d transition to 100% finisher) were compared to a traditional 21-d adaptation. Dry matter intake responded quadratically across treatments, with the greatest intake observed in …

Predicting And Decoding Allosteric Binding Sites Using Protein Language Models And Structure-Based Machine Learning: An Energy Landscape-Guided Explainable Ai Framework, Kamila Riedlová, Vít Skrhák, William G. Gatlin, Max Ludwick, Lucas Turano, Marian Novotný, David Hoksza, Gennady M. Verkhivker

Mathematics, Physics, and Computer Science Faculty Articles and Research

Computational prediction of allosteric binding sites in protein structures remains a persistent challenge, as these regulatory pockets evade detection by both sequence-based and structure-based algorithms. Both computational and physical origins of this predictive asymmetry remain insufficiently understood. In this study, we systematically examine the determinants of binding site predictability using a dual framework that integrates a fine-tuned protein language model and the structure-based method P2Rank as complementary tools probing a diverse data set of 453 human kinases, together with a physics-based interpretability layer derived from energy landscape frustration analysis. Both predictors exhibit a sharp and reproducible dichotomy on protein kinases, …

Faith, Science, And Choice: Vaccine Attitudes Among Religious University Students, Jamie Jensen

ScholarsArchive Data

These data comprise a Q-methodology study conducted at Brigham Young University among undergraduate students to determine vaccine attitudes in relation to religious and political ideologies. It includes raw sort data, templates for running Q-methodology, and interview transcripts.

Proteomics And Alkaloid Signature Of Narrow Leaf Lupin Leaves Reveal Key Enzymes In Quinolizidine Alkaloid Biosynthesis And Transportation, Tawfeek Khedr, Ling Ling Gao, Lars G. Kamphuis, Utpal Bose, Mitchell G. Nye-Wood, Angéla Juhász, Michelle L. Colgrave

Research outputs 2022 to 2026

Quinolizidine alkaloids (QAs) are toxic secondary metabolites in narrow-leafed lupin that defend against herbivores but constrain food and feed use. We developed a single-sample multiomics workflow for simultaneous extraction and quantitative analysis of QAs and proteins from individual leaves using urea/thiourea/CHAPS extraction with acetone precipitation, validated for QA quantification by LC–MS/MS. Data-independent acquisition proteomics of eight lupin accessions (four bitter, four sweet) identified 4437 proteins, with 183 differing significantly between bitter and sweet groups. Bitter accessions were enriched in lysine biosynthesis and stress-response pathways, whereas sweet accessions showed enrichment in phenylpropanoid and other defense-related processes. Coexpression network analysis linked protein …

Bioinformatic Resolution Of Candidate Stress-Response Homologs In Cryptosporidium Parvum: P53-Family Vs Sestrin Identity, Freeman Tobechukwu Ezeala Mr.

Biochemistry and Molecular Biology

Cryptosporidium parvum is an apicomplexan protozoan of major public-health importance, but accurate genome annotation in this organism remains difficult because of its compact genome, deep protein divergence, and the presence of compositionally biased or low-complexity regions that can mislead similarity-based analysis.

In this thesis, I examined one such annotation problem involving a conserved Cryptosporidium stress-response candidate protein, CPATCC_0028580_t1 (833 aa). The central question was whether this protein is better interpreted as a member of the p53 family, based on similarity to p53-like DNA-binding domains (PF00870), or as a member of the Sestrin family associated with the PA26 domain.

I explored …

Examining Biobehavioral Indicators Of Adhd In Children With Fxs, Hannah Pressler, Kayla Smith, Ramsey Coyle, Elizabeth Will, Jane E. Roberts

Caravel Undergraduate Research Journal

Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by inattention and hyperactivity/impulsivity behaviors that are inconsistent with developmental age. Children with fragile X syndrome (FXS), a genetic neurodevelopmental disorder, are often diagnosed with comorbid ADHD (53–59% of males with FXS). Despite the prevalence of ADHD in FXS, little is known about the early manifestation of ADHD. The current project aims to explore group differences in play behaviors between children with FXS and typically developing (TD) children as well as the relationship between infant play behavior and heart activity to future ADHD attention outcomes. Participants included male children with FXS and …

Optimizing Expression Conditions For The Overexpression Of Iron Regulatory Protein Bol2 From C. Glabrata, Jade Ikahihifo-Bender, Dr. Caryn Outten, Mrs. Evan Talib

Caravel Undergraduate Research Journal

Due to its unique ability to serve as both an electron donor and acceptor, iron is utilized as a co-factor for many biological processes, including electron transfer, oxygen binding, and vitamin synthesis. Iron is also a key factor during fungal infections as the human host and invading pathogens battle over limited iron pools. The primary iron-responsive transcription factor Aft1 in the opportunistic pathogenic yeast Candida glabrata responds to iron deficiency by activating expression of iron acquisition genes. However, the mechanisms for sensing intracellular iron levels and regulating Aft1 activity in response to iron are unknown. The C. glabrata iron regulation …

Early Behavioral And Physiological Predictors Of Autism In 12-Month-Old Siblings Of Children With Autism, Nicolas Poupore, Kayla Smith, Abigail L. Hogan, Jane E. Roberts Ph.D.

Caravel Undergraduate Research Journal

Autism spectrum disorder (ASD) is a neurodevelopmental disorder defined by social-communicative deficits and repetitive behaviors. Complementing behavioral (i.e., The Autism Observation Scale for Infants (AOSI) scores) and physiological markers (i.e., respiratory sinus arrhythmia (RSA), heart rate (HR)) may improve early identification of ASD and provide insights into the neurobiological mechanisms contributing to early ASD symptoms. Younger siblings of a child with ASD (ASIBs) had significantly higher AOSI Total Scores and AOSI Marker Scores in comparison to Low Risk Controls (LRCs). RSA significantly decreased from a Baseline to AOSI for both groups, but only for the ASIB group was a negative …

A Review Of Video Game Effects And Uses, David Corso

Caravel Undergraduate Research Journal

Video games are versatile in their form and function. Whether they’re training doctors or offsetting Alzheimer’s disease, video games can exercise both mental and physical features, train specific skills for a number of jobs, educate players about events and phenomenon in our world, research and understand natural human processes, and they can be designed for a number of other purposes. Multiple studies have demonstrated the effects of video games on physiological and cognitive levels—positive, negative, and everything in between. This paper identifies various physical and psychological effects that video games produce, and it suggests ways in which video games can …

Double Cropping Fodder Maize: Broome 2022, Carla Milazzo, Christopher Ham, Geoff Moore

Grain and other field crops research reports

• While it is logistically feasible to grow and harvest two short-season maize crops during the dry season in the West Kimberley, growing a single crop with high yield potential is a more efficient use of machinery, labour and inputs.
• Total biomass yield from a double cropping trial east of Broome generated 20.8t/ha dry matter and 59.7t/ha of silage over a seven-month period but this did not exceed the yield achieved from growing a single crop with a longer-season phenology and best practice agronomy.
• Plant population density was highly correlated with yield, underscoring the importance of achieving the target plant population …

Teaching Exercise: A Survey On Educational Aids And Self-Efficacy, Joshua I. Eaton, Lucas Morgan, Matthew Hermes

Honors College Theses

HEPs are an important part of therapeutic treatment because they allow for greater exercise stimulus than can be achieved from supervised exercise alone. 94.7% of physical therapists reported prescribing HEPs to their patients. However, patient adherence to these plans can be as low as 35%. Lack of HEP adherence likely leads to sub-optimal clinical outcomes in physical therapy patients. Self-efficacy is improved in patients by supplementing HEPs with instructional aids, especially in the form of videos instead of pictures or descriptions, because they act as a form of vicarious experience. It is possible that improving self-efficacy through vicarious experience could …

Stemflows And Preferential Flows: A Historical Review And Challenges For The Future, Keith Beven, John T. Van Stan Ii

Biological, Geological, and Environmental Faculty Publications

This paper provides a historically-grounded review and research agenda on a generally neglected issue in hillslope hydrology and hydrological modelling: the role of stemflow in initiating preferential flow in soils. While stemflow typically represents a small fraction of incident rainfall, it can concentrate water fluxes by up to similar to 20-fold at tree bases, creating localised infiltration intensities that exceed those from throughfall. Some new historical context for throughfall and stemflow studies from the 19th Century is presented, including a summary of stemflow research in a wide range of vegetation types and environments. The evidence for preferential flows resulting from …

Neural Mechanisms Underlying Jung’S Active Imagination: A Review And Hypothesis, Charles R. Fox

Journal of Conscious Evolution

Active imagination is a key technique of Jungian analysis. Despite its centrality, and its potential importance beyond Jungian psychology to the area of systems neuroscience, psychology, and consciousness studies, there are no known neurological mechanisms underlying this psychological phenomenon. There is a history of using the types of mental imagery used in active imagination to explore consciousness. The development and use of active imagination is briefly reviewed, and a case is developed that the neurology underlying active imagination would be fruitfully explored by considering it a special case of mystical experience. Active imagination primarily uses the right hemisphere processing of …

Prevalence, Determinants, And Objective Risk Of Unintentional Therapeutic Duplication Among Adults In Saudi Arabia, Yosra Alhindi

Saudi Toxicology Journal

Background: Unintentional therapeutic duplication represents an underrecognized yet preventable contributor to medication-related harm, particularly in settings characterized by widespread over-the-counter (OTC) medicine use and self-medication practices. Objective: To estimate the prevalence of unintentional therapeutic duplication among adults in Saudi Arabia and identify sociodemographic and behavioral predictors associated with increased therapeutic duplication risk. Methods: A national crosssectional study was conducted between February 10 and April 28, 2025, using a structured, self-administered online questionnaire distributed via social media platforms. The survey assessed sociodemographic characteristics, medication-use behaviors, active-ingredient literacy, and duplication risk using both self-reported measures and scenario-based assessments. Multivariable logistic regression was …

Assessing The Risk Of Low Energy Availability In Ncaa Division Iii Female Soccer Players, Emma C. Sturts

Masters Theses/Capstone Projects

Low Energy Availability (LEA) can occur when an athlete’s energy intake is insufficient to meet the physiological demands of training as well as normal physiological functions. Female soccer players may be at an increased risk of developing LEA due to the high exercise energy expenditure paired with decreased energy intake. The purpose of this study is to assess the prevalence of LEA among Division III female soccer players. Division III female soccer players (n = 11) completed the Low Energy Availability in Females Questionnaire (LEAF-Q). 45.5% (n = 5) of the participants were classified as “At Risk” for LEA. Of …

Employing Zebrafish To Understand Genetic Drivers Of Epilepsy-Related Comorbid Behaviors, Chinwendu Ononuju, Kharma Hall, Olivia Beatty, Scott C. Baraban, Colleen Carpenter-Swanson

Biology Faculty Publications

Children with epilepsy frequently experience a range of significant comorbidities beyond seizures, such as motor dysfunction, cognitive impairment, and neurodevelopmental delays. In some cases, these comorbidities contribute more significantly to overall disease burden than the seizures themselves. To improve quality-of-life (QOL) for these children, treatment options should be selected that control seizures and ameliorate comorbidities. Unfortunately, such therapeutics remain largely elusive. Addressing this issue requires suitable preclinical models. Here we used CRISPR-generated zebrafish with single-gene mutations linked to pediatric epilepsy and applied clinically-relevant behavioral assays to study the effects of these mutations. Using high-throughput locomotion-based assays, we uncovered errors in …

From Confidence To Competence: Embedding Critical Genai Literacy In Physician Associate Education, Chanceeth Chandrakanthan, Amy H. Donaldson-Perrott Mrs, Jane Secker, Julie Voce, Tamara S. Ritsema

Journal Of Indian Physician Associates

Background: Generative artificial intelligence is now embedded in how many healthcare students learn. Tools provide rapid explanations, summaries and practice questions, but use does not equal AI literacy, particularly where accuracy, medicines safety and guideline alignment matter.

Objective: To describe current use of generative AI by Physician Associate students and outline a practical approach to teaching critical AI literacy.

Methods: Educational evaluation using three activities: (1) baseline survey of students about use and attitudes, (2) an embedded compare and critique session in applied pharmacology where small groups assessed AI answers against trusted UK sources, including BNF and NICE guidance, followed …

The Impacts Of High Protein Diet On Sleep And Mood In Women With Polycystic Ovary Syndrome (Pcos), Lily G. Hiegel

Biological Sciences Undergraduate Honors Theses

The objective of this study is to determine whether adherence to a high protein diet over a sixteen-week period leads to improvements in sleep quality and mood in women with PCOS. It is hypothesized that individuals following the high protein diet will demonstrate significantly better sleep quality and more favorable mood profiles compared to individuals not following the high protein diet. By targeting insulin resistance and dietary carbohydrate intake, this intervention may influence multiple pathways involved in PCOS symptomatology, including hormonal regulation, metabolic function, sleep physiology, and psychological wellbeing.

Status Of The Potentially Invasive Australian Redclaw Crayfish (Cherax Quadricarinatus), Margaret (Addie) Munn

Biology Theses

The introduction of invasive species, including crayfish, is common through aquaculture and aquarium trade pathways and is an important factor causing the decline and/or extinction of native species. Invasive species cause billions of dollars in damages annually and threaten almost half of the native species in the United States. Australian Redclaw Crayfish (Redclaws) are a species of large individuals that originated in Australia and New Guinea and have been introduced specifically for aquaculture and the aquarium trade. Redclaws are known to thrive in tropical and subtropical locations. They can tolerate high temperatures and low oxygen and are generalist omnivores that …

Reducing Textile Waste Through 3d Body Scanning Technology: A Comparative Study Of Traditional And Digital Apparel Design Methods, Anna Delap

Apparel Merchandising and Product Development Undergraduate Honors Theses

The fashion industry generates a substantial amount of textile waste each year, highlighting the need to incorporate more sustainable methods in the design and production of apparel garments. Emerging technologies such as three-dimensional (3D) body scanning and digital design software present the potential to reduce the amount of waste generated during product development while also improving fit and customer satisfaction. The purpose of this study was to investigate the potential of 3D body scanning to reduce waste in the apparel industry by comparing garment development using 3D digital design and traditional flat pattern design methods.

In this study, 3D body …

How Does Five Days Of Tapering Effect Rates Of Fatigue And Recovery In Collegiate Male Swimmers?, Riley Yerks

Celebrating Scholarship and Creativity Day (2018-)

This study was conducted on the members of the 2025-26 St. John's "Johnnies" swim and dive team. This study used both subjective surveys and objective HRV readings that the swimmers took before and after practice. The first day of testing occurred on the last day of the regular training season, and the second day of testing occurred on the last day of tapered training. Results of the surveys and HRV readings were compared between pre and post-practice, and pre and post-taper. The subjective surveys showed how the swimmers themselves felt in terms of physical and mental energy and fatigue, and …

Effects Of Dietary Nitrate And Caffeine On End Power And Work Above End Power During A 3 Min All-Out Test In Trained Male Cyclists, Anthony M. Hagele, Kyle Sunderland, Petey W. Mumford, Chad Kerksick

Faculty Scholarship

Background: The purpose of this study was to examine the effects of acute dietary nitrate (NO3−) and caffeine (CAF) supplementation on end power (EP) and work performed above EP (WEP) in trained male cyclists during a 3 min all-out test (3MT) on a cycle ergometer.

Methods: Fifteen healthy, trained male cyclists (28.5 ± 5.3 years, 79.2 ± 9.1 kg, VO2peak 55.2 ± 5.6 mL·kg−1·min−1) completed four exercise trials in a randomized, double-blind, placebo-controlled, crossover study design separated by 3–7 days. The four experimental conditions were placebo beverage (nitrate-depleted) + placebo capsule, nitrate-rich beetroot juice + placebo capsule (BR), …

Efficacy Of Tick Sampling Methods In Urban Parks., Emma Staples

College of Arts & Sciences Senior Theses

Amblyomma americanum (Lone star ticks) are parasites and vectors of diseases, including Ehrlichiosis. Questions remain about how an urban environment affects the host-seeking behavior of A. americanum across different life stages and thus the efficacy of different sampling methods. We sought to compare the efficacy of different sampling methods on A. americanum ticks in urban parks during the fall season and explore how the urban heat island (UHI) effect may impact each method’s efficacy. We hypothesized that, where the UHI effect is weaker near the city’s periphery, the CO₂ trapping method would collect more A. americanum adults and nymphs …

The Influence Of Valence On Action Control: A Comparison Of Simon Effects In The Extrinsic Affective Simon Task (East) And The Spatial Simon Task, Yaara Aleissa

College of Arts & Sciences Senior Theses

People adjust their thoughts and actions in response to a changing environment every day and emotions may influence these actions. Understanding how emotion impacts action control in situations where emotion is central to the action (task-relevant) compared to when it is present in the environment as distracting information (task-irrelevant) is essential. Currently it is unclear when emotion most significantly modulates action control. This study seeks to compare how valence (positive versus negative emotion) impacts action control performance when valence is task-relevant and task-irrelevant by using two modified versions of the Simon conflict task.

The Simon task is a paradigm to …

Ai×Life 2026: Advances In Computational Biology Across Scales For Life & Health Sciences, Suma Mohan S., Devika N. T., Pranavathiyani G.

Conference Proceedings

Book of Abstracts of the International Conference, AIxLife 2026: Advances in Computational Biology Across Scales for Life & Health Sciences, held on 17–18 April 2026, SASTRA Deemed to be University, Thanjavur, Tamil Nadu, INDIA 

About the Conference

Conventional computational biology laid the foundation for biological data analysis through statistical models, algorithms, and curated databases, enabling insights into genes, proteins, and pathways. Today, the integration of artificial intelligence, spanning machine learning, deep learning, and large language models (LLMs) is driving a transformative shift across biological scales, from atomic and molecular interactions to pathways, cellular systems, organisms, and populations.

AI-powered approaches …

Sustainability Of Peatland Area Management With Peat Drainability Assessment At Various Depths, Aulia Bahadhori Mukti, Heru Bagus Pulunggono, Yuli Suharnoto

Jurnal Penelitian Kehutanan Wallacea

This study aims to analyze the distribution of drainability assessment components, including Peat Basal Contact (PBC) and Natural Drainage Limit (NDL) elevations, Drainage Limit Time (DLT), and volume loss, as well as their relationship with peat thickness, subsidence, and groundwater level (GWL) in peatlands. The assessment is conducted to estimate the potential productive lifespan of oil palm plantations by determining the natural drainage limit (NDL) and predicting the time required to reach the drainage threshold, considering subsidence rates across different peat thickness classes. The analysis and calculations were performed using the drainage assessment formulas and procedures outlined by the Roundtable …

Exploring Google Trends In Assessing Personal Finance Needs For Cooperative Extension Service Programming, Megan Wells

Graduate Theses and Dissertations

The Cooperative Extension Service (CES) relies on systematic needs assessments to guide program development; yet, traditional approaches often depend heavily on stakeholder input and professional judgment, offering limited insight into consumer level needs. This mixed methods study explored Google Trends as a complementary, consumer driven data source for assessing Family Resource Management (FRM) needs within the Arkansas CES. Grounded in Witkin and Altschuld’s three level needs assessment framework and Uses and Gratifications Theory, the study integrated three data sources representing stakeholders, service providers, and consumers: (1) Family and Consumer Sciences (FCS) advisory committee reports, (2) survey of Family Consumer Science …

Shape Variation In The Mandible Of The Borophagine Canids And Implications For Predatory Behavior, Benjamin Neavear

Theses, Dissertations and Culminating Projects

The borophagines are an extinct lineage of canids that inhabited North America for more than 20 million years. This group included genera such as Aelurodon, Borophagus, and Epicyon. Borophagines are commonly referred to as “bone-crushing dogs” because their skull morphology converged with that of extant hyenas, predators capable of consuming bone. The purpose of this study was to determine whether convergence was present in the mandible, an anatomical structure strongly correlated with feeding behavior, particularly in the genera Aelurodon and Borophagus. It was hypothesized that most borophagine taxa possessed mandibular shapes similar to those of hyenas. Numerous mandibular characters were …