Digital Commons Network^™

Phase Ii Basket Trial Of Dual Anti-Ctla-4 And Anti-Pd-1 Blockade In Rare Tumors (Dart) Swog S1609: Pancreatic Neuroendocrine Neoplasm (Pnen) Cohort, Sandip Pravin Patel, Jillian Fisher, Young Kwang Chae, Luisa Solis Soto, Anup Kasi, Mark Walshauser, Jiexin Zhang, Caroline Duault, Edgar Gonzalez-Kozlova, Ganiraju Manyam, Jianhua Zhang, Hong Chen, Dzifa Yawa Duose, Caddie Laberiano Fernandez, Raja Luthra, Gheath Al-Atrash, Seunghee Kim-Schulze, Holden T Maecker, Ignacio I Wistuba, Sacha Gnjatic, J Jack Lee, Jianjun Zhang, Christine M Magner, Helen X Chen, Elad Sharon, Megan Othus, Christopher W Ryan, Charles Blanke, Cara L Haymaker, Razelle Kurzrock

Faculty, Staff and Student Publications

Purpose: SWOG S1609 Dual Anti-CTLA-4 and anti-PD-1 blockade in Rare Tumors (DART) studied the efficacy of ipilimumab combined with nivolumab across multiple rare tumor types. We report the results of the pancreatic neuroendocrine neoplasm (PNEN) cohort.

Experimental design: Treatment consisted of ipilimumab 1 mg/kg intravenously every 6 weeks with nivolumab 240 mg intravenously every 2 weeks. The primary endpoint was overall response rate (ORR) (Response Evaluation Criteria In Solid TumorsRECIST V.1.1). Secondary endpoints include progression-free survival (PFS), overall survival (OS), and toxicity. Clinical benefit rate (includes ORR plus stable disease (SD)>6 months was examined. Correlative …

Vitamin D3 Toxicity-Induced Hypercalcemia In Staphylococcal Arthritis: A Focus On Il-6, Ali Jabbar Abd Al-Hussain Alkawaz, Maryam Sabah Naser, Ali Jalil Obaid, Zakaria M. Al-Ghazaly

Karbala International Journal of Modern Science

Background: Vitamin D3  over-supplementation can induce toxicity through the development of hypercalcemia and may disturb immune modulation. This study examines the relationship between hypercalcemia  resulting from Vitamin D3 Overdose and serum Interleukin-6 (IL-6) levels in patients diagnosed with staphylococcal arthritis.

Methods: Forty male patients (mean age: 31 years; range: 17–45 years) were enrolled from Dec. 2024 to Feb. 2025. Twenty cases of staphylococcal arthritis were compared with twenty healthy male controls. Serum concentrations of Vitamin D3, calcium, IL-6, and other biochemical markers (urea, creatinine, ESR, WBC, and potassium) were analyzed. Staphylococcus aureus was isolated from synovial fluid and confirmed using …

Ifi16 Mediates Deacetylation Of Kshv Chromatin Via Interaction With Nurd And Sin3a Co-Repressor Complexes, Anandita Ghosh, Bala Chandran, Arunava Roy

School of Medicine Faculty Publications

IFI16 is a well-characterized nuclear innate immune DNA sensor that detects foreign dsDNA, including herpesviral genomes, to activate the inflammasome and interferon pathways. Beyond immune signaling, IFI16 also functions as an antiviral restriction factor, promoting the silencing of invading viral genes through transcriptional and epigenetic mechanisms. We recently demonstrated another role of IFI16, in which it interacts with and recruits the class I histone deacetylases, HDAC1 and 2, to the KSHV latency protein LANA, modulating its acetylation and function. In this study, we asked whether these IFI16-HDAC1/2 interactions contribute to broader epigenetic regulation of the KSHV chromatin. Our findings reveal …

Genomics-Based Taxonomic Refinement Of Emesis Fabricius (Lepidoptera: Riodinidae), Jing Zhang, Qian Cong, Jinhui Shen, Leina Song, Nick V. Grishin

Insecta Mundi

Expanded genomic sequencing of Emesis [Fabricius], 1807 (Lepidoptera: Riodinidae Grote, 1895) reveals additional taxonomic insights. As a result of this study, one subgenus and 10 species are proposed as new (type species or type localities in parenthesis): Sinuata Grishin, new subgenus (Emesis sinuatus Hewitson, 1877) of Exoplisia Godman and Salvin, 1886; Emesis (Mandania) mandaca Grishin, new species (Mexico: Oaxaca); Emesis (Mandania) mantunga Grishin, new species (Ecuador: Tungurahua); Emesis (Tenedia) hidalga Grishin, new species (Mexico: Hidalgo); Emesis (Tenedia) vera Grishin, new species (Mexico: Veracruz); Emesis (Tenedia) nica Grishin, new species …

Daily Movement Activities Are Associated With Within-Person Instability Of Cognitive Function In Older Adults: Evidence From An Ambulatory Assessment Study, Chih-Hsiang Yang, Donald Hedeker, Jongwon Lee, Halle Prine, Donna Coffman, Jingkai Wei, Jonathan George Hakun

Faculty Publications

Background and Objectives

Physical inactivity and excessive sedentary time (ST) are associated with poor cognitive health in older adults. However, current literature largely relies on cross-sectional designs or in-lab cognitive assessments, which do not adequately reflect cognitive function in naturalistic settings. Further, existing studies have largely overlooked the variability or the instability in daily cognitive function, which represents a critical marker of cognitive decline. This ambulatory assessment study examined the temporal associations of daily movement behaviors with the mean levels and the variability of cognition among older adults at risk of dementia. Research Design and Methods

96 older adults from …

An Fgfr-P53 Developmental Signaling Axis Drives Salivary Cancer Progression, Julia M. R. Billington

USF Tampa Graduate Theses and Dissertations

Mucoepidermoid carcinoma (MEC) is the most frequently occurring salivary gland malignancy.Here, we investigated transcriptomic profiles of human fetal and adult salivary glands and MEC tumors to assess programs involved in MEC progression. Molecular and genetic analyses revealed that MEC tumors and fetal salivary glands share proliferative and developmental gene expression profiles that implicate an FGFR-p53 signaling axis in salivary MEC progression. Based on these findings, we developed a genetically engineered mouse model of advanced MEC via targeted expression of the CRTC1-MAML2 oncogene in salivary ductal cells. Specifically, CRTC1- MAML2 expression combined with p53 dysregulation in salivary ducts rewires FGF signaling …

Erratum To Golovatch Et Al. (2025): Contributions To The Taxonomy Of The Neotropical Millipede Genus Iulidesmus Silvestri, 1895 (Diplopoda: Polydesmida: Paradoxosomatidae: Catharosomatini), Sergei I. Golavatch, Juan Romero-Rincon, Nesrine Akkari, Santiago Alvear

Insecta Mundi

After publication of Golovatch et al. (2025), it was noticed that Figure 3 was accidentally omitted. The authors and the Insecta Mundi editorial staff apologize for this error. Figure 3 is reproduced here. Insecta Mundi has also released a revised version of the Golovatch et al. (2025) manuscript, with this error corrected. However, the revised version is not an official version of record, and anyone wishing to reference the findings of Golovatch et al. (2025) should cite the original manuscript or this erratum.

Impact Of Oceanographic Gradients And Marine Heatwaves On The Picophytoplankton Community In The Northern California Current System, Kristin E. Forgrave, Carey P. Sweeney, Melissa Steinman, Anvita U. Kerkar, Timothy M. Pettit, Anne W. Thompson

Biology Faculty Publications and Presentations

The Northern California Current (NCC) system is a productive coastal ecosystem with a mosaic of temporal and spatial features. The phytoplankton community plays a crucial role in supporting the rich ecosystem and economically important fisheries of the NCC. Our study integrates data across two years (2022-2023) and multiple transects to investigate the community composition of two major phytoplankton groups in the NCC: picocyanobacteria and photosynthetic picoeukaryotes (PPE). The abundances and cell sizes of the phytoplankton were measured using flow cytometry. We found PPE present at similar concentrations in both summer and winter, while picocyanobacteria were much more abundant in the …

Kinematic Analysis Of Olympic And Traditional Rowing Mechanics At Different Stroke Rates, Alfonso Penichet-Tomas, Sergio Calavia-Carvajal, Basilio Pueo, Lamberto Villalon-Gasch

International Journal of Exercise Science

International Journal of Exercise Science 18(7): 610-621, 2025. Rowing requires strength, endurance, and technique, where stroke efficiency depends on body mechanics, movement sequencing, and stroke rate, which impact speed transfer. This cross-sectional study investigates the role of kinematic differences in stroke mechanics as a key component of performance analysis in Olympic and Traditional rowing. Thirteen elite national-level female rowers (age: 26.9 ± 5.1 years; body mass: 60.6 ± 6.9 kg; height: 166.7 ± 6.7 cm) performed three stroke-rate conditions on two ergometer setups: an Olympic rowing ergometer and a modified ergometer with a static seat replicating Traditional rowing. The stroke …

The Effect Of Breakfast On A Resistance Training Session And Response In Female Collegiate Athletes, Haley Roberts, Yvette Figueroa, Jennifer Bunn, Patrick Davis

International Journal of Exercise Science

International Journal of Exercise Science 18(6): 591-609, 2025. Breakfast consumption has been shown to be an essential component to a healthy lifestyle in various populations, yet research in this area is limited among female athletes. This study aimed to examine the effect of breakfast consumption on collegiate female athletes during a resistance training session and their nutritional habits throughout the remainder of the day. Twenty-three female collegiate Division I athletes (basketball, volleyball, bowling, and soccer) during the offseason participated in this cross-over study. The study included three visits: baseline measures for heart rate (HR), blood glucose (BG), salivary cortisol (SC), …

Agronomic Methods To Increase Pastureland Production In Mediterranean Marginal Areas, P Bullitta, Simonetta Bullitta, P P. Roggero

IGC Proceedings (1977-2023)

Sardinian pasturelands covering 1.200.000 ha represent nearly the 50 % of the island surface and are the most import­ant resource for animal feeding. Pastureland productivity is scarce, annual dry matter ranging from 6 to 12 q ha-1. Low pro­duction is mainly due to climate, scarce deepness and type of soils and by competition of mediterranean shrubs, mainly Cistus spp. that infests nearly 500.000 ha with a percentage of covering ranging from 20 to 100 % . The control of Cistus is normally done by means of fire and by ploughing but results are poor because a correct management of the …

Diagnostics Des Conduites De Paturage Tournant Et Continu Chargement, Hauter D'Herbe Et Jours D'Avance, J L. Fiorelli, J Husson, B Lavalette, E Vaubernier

IGC Proceedings (1977-2023)

L'efficacite d'une conduite de paturage reside dans son apti­tude a favoriser la production animale au moyen, notamment, de la mise a la disposition du troupeau d'une ressource herbacee la moins limitante possible (en quantite et en qualite) par rapport au potentiel de production des animaux et ce, le plus longtemps et le plus regulierement possible durant la periode de vegetation. Si le resultat zootechnique est generalement assez aisement evaluable, par contre les modalites de conduite du paturage ne sont que fort peu considerees. En consequence, aucun diagnos­tic ne peut etre correctement etabli et les recommendations d'amelioration eventuelle restent le plus …

Efficiency Measurement Of Pasture Use On Dairy Farms, G J. Piggot, D G. Clayton

IGC Proceedings (1977-2023)

Dairy farmers in northern regions of New Zealand look to Ruakura Research Station to provide them with technical information on farm production. Ruakura farms are outstand­ing examples of fully pasturefed dairy technology. In regions distant from the research station, such as Northland, parochial attitudes inhibit the complete extension of research station results. The project described here aimed to examine the current management practices on typical dairy farms in North­land. By identifying differences between Northland farms and Ruakura research farms, corrective management strategies could be recommended in order to increase dairy farm efficiency in the region.

Corn Stover In Comparison With Pasture Hay For Beef Production In Temperate Areas Of Argentina, J A. Josifovich, J Carrete

IGC Proceedings (1977-2023)

The amount of corn stover left in the fields after the harvest in the humid Pampa of Argentina can be estimated in 18 mil­lions tons. Even large part of these residues are grazed by bovines, in general this is done in fall, after harvest, during short periods (Josifovich, 1975), (Maddaloni, 1981), (Fattet, 1981). Part of this large amount of forage can be transferred to winter as large round bales. The efficiency of these reserves can be more useful in winter, during the dry season. Due to low quality these residues can't be used alone, with confined anim­als (Jackson, 1978; Maddaloni …

Production De Viande Bovine Et Ovine Sur Prairie Dans Les Monts Sudetes, Janina Fatyga

IGC Proceedings (1977-2023)

Par suite du depeuplement des villages et de !'abandon de la culture dans des zones situees en altitude dans !es Sudetes, on y observe l'accroissement de la superficie des paturages perma­nents. Des 1968, on y cree des zones de pature OU en ete de jeu­nes bovins et des ovins provenant des fermes situees plus bas sont conduits en permanence. L'importance du phenomene est illustre par le fait qu'a present, sur le terrain d'une seule region de Walbrzych, il y a 103 bases de pature d'une superficie de 7.000 ha, appartenant a 54 fermes d'etat ou paissent environ 25.000 ovins et …

Changes In Immune-Regulated Gene Methylation Over Time In Women Who Do And Do Not Develop Breast Cancer, Kyle Laney

USF Tampa Graduate Theses and Dissertations

Breast cancer survivors face elevated risks of chronic inflammatory conditions and immunedysfunction compared to the general population. These elevated health risks in survivors are well-documented but mechanistically poorly understood. This study aimed to characterize longitudinal changes in DNA methylation patterns of immune-regulatory genes in women who developed breast cancer compared to cancer-free controls. We conducted an EWAS using Sister Study cohort data, analyzing longitudinal changes in DNA methylation by comparing the difference in beta values between pre- and post-diagnosis time points in breast cancer cases versus changes over the same period in cancer-free controls. The analysis included 414 participants: 189 …

Screening Of Ccdc43 Molecular Partners By Bioid2-Based Proximity Labeling, Merve Tuzlakoğlu Öztürk

Turkish Journal of Biology

Background/aim: CCDC43 (coiled-coil domain containing protein 43) is a eukaryotic protein that contains alpha-helical domains in its structure, consistent with the family to which it belongs. It is predominantly located in the cytosol of the cell. CCDC43 protein has been shown to play a role in cell proliferation, invasion, metastasis, and epithelial–mesenchymal transition in gastric and colorectal cancer types. The fundamental function and cellular interaction network of this protein, which is known to have varying expression levels in various cancer types, has not yet been fully elucidated. Here, we conducted a proximity-dependent biotin identification (BioID2) screening approach for CCDC43 to …

Accurate Crop Yield Prediction Via Temporal Convolutional Network And Variational Autoencoder, Lei Liu, Xiaoling Song

Turkish Journal of Agriculture and Forestry

With the advancement of technology, smart agriculture assumes a pivotal role in enhancing the efficiency and sustainability of agricultural production. Nevertheless, accurately forecasting crop yields and understanding their determining factors often faces limitations inherent in conventional data processing techniques. To address this challenge, this study proposes a TCN-VAE framework, amalgamating temporal convolutional networks (TCNs) and variational autoencoders (VAEs), to tackle the crop yield prediction task in smart agricultural systems. The framework intricately models four principal categories of features—meteorological conditions, soil conditions, agricultural management, and environmental conditions—via TCN and compensates for missing data using VAE, thereby achieving a comprehensive analysis and …

A Rubric For Assessing Conformance To The Ten Rules For Credible Practice Of Modeling And Simulation In Healthcare, Alexandra Manchel, Ahmet Erdemir, Lealem Mulugeta, Joy Ku, Bruno Rego, Marc Horner, William Lytton, Jerry Myers, Rajanikanth Vadigepalli

Computational Medicine Center Faculty Papers

The power of computational modeling and simulation (M&S) is realized when the results are credible, and the workflow generates evidence that supports credibility for the context of use. The Committee on Credible Practice of Modeling & Simulation in Healthcare was established to help address the need for processes and procedures to support the credible use of M&S in healthcare and biomedical research. Our community efforts have led to the Ten Rules (TR) for Credible Practice of M&S in life sciences and healthcare. This framework is an outcome of a multidisciplinary investigation from a wide range of stakeholders beginning in 2012. …

Green Biosynthesis Of Cobalt Oxide Nanoparticles Using Saccharum Munja Leaf Extract As A Catalyst For Callus Induction In Carnation (Dianthus Caryophyllus L.) Plants, Ishtiaq Ahmad, Sameed Arshad Chaudhry, Maryam Maryam, Aysha Arif Chahel, Riaz Ahmad, Mehmet Ramazan Bozhüyük, İbrahi̇m Bozkurt, Magda Abdel-Rahman, Konstantin Korolev

Turkish Journal of Agriculture and Forestry

The common name of a wild grass native to Pakistan with both edible and medicinal properties is Saccharum munja Roxb. (S. munja). Prior research has investigated various plant species for the green biosynthesis of nanoparticles to circumvent issues related to their physical and chemical production. This study presents the first evidence of synthesizing cobalt oxide nanoparticles (Co3O4NPs) using S. munja leaf extract (SMLE) as both a reducing and a capping agent. This study investigated their ability to induce in vitro callus formation in Dianthus caryophyllus L. (carnation). In this study, Co3O4NPs were synthesized using varying quantities of SMLE to achieve …

A Comprehensive Review Of Fermentation Technologies In Food Processing: From Traditional To Cutting Edge, Pragati Singh, Niharika Arya, Shalini Sharma, Ankita Sharma, Prasad Rasane, Supriya Singh Gaur, Sawinder Kaur, Mahendra Gunjal, Hasan Kiliçgün, Jyoti Singh

Turkish Journal of Agriculture and Forestry

Fermentation technologies play crucial roles in food processing, offering various advantages, including enhanced flavor profiles, extended shelf life, and improved nutritional qualities. This paper provides a comprehensive overview on the major types of fermentation as well as effects of various factors such as substrate composition, temperature, pH, oxygen availability, and microbial strain selection on the process. Despite its widespread application, traditional fermentation processes face limitations related to yield optimization, contamination risks, and process consistency. Recent advancements have significantly enhanced fermentation efficiency, product quality, and scalability, ultimately expanding the applications beyond food and beverage production into pharmaceuticals, nutraceuticals, biofuels, and waste …

Isolation And Selection Of Bacillus Spp. As Candidate Probiotics For Use In Chickens, Adilah Adawiah, Komang Gede Wiryawan, Anja Meryandini

Makara Journal of Science

The growth rate of chickens can be improved by using probiotics as alternatives to antibiotics. Bacillus spp. as probiotics are particularly beneficial due to ability to form spores, which remain stable as commercial products over extended periods. This study aimed to isolate and select Bacillus spp. from Jasinga soil as probiotic candidates for chickens. A total of 15 isolates obtained of these, 12 were identified as Bacillus spp based on microscopic observations and screening test including ascertaining hemolysis, protease, amylase, and cellulase activities. Only six isolates exhibited gamma hemolysis and the ability to hydrolyze proteins, starch, and cellulose. Isolates BTJ1.1, …

A Conditional Point Cloud Diffusion Model For Deformable Liver Motion Tracking Via A Single Arbitrarily-Angled X-Ray Projection, Jiacheng Xie, Hua-Chieh Shao, Yunxiang Li, Shunyu Yan, Chenyang Shen, You Zhang

Faculty, Staff and Student Publications

Objective. Deformable liver motion tracking using a single x-ray projection enables real-time motion monitoring and treatment intervention. We introduce a conditional point cloud diffusion (PCD) model-based framework for accurate and robust liver motion tracking from arbitrarily angled single x-ray projections. Approach. We propose a conditional PCD model for liver motion tracking (PCD-Liver), which estimates volumetric liver motion by solving deformable vector fields (DVFs) of a prior liver surface point cloud, based on a single x-ray image. It is a patient-specific model of two main components: a rigid alignment model to estimate the liver’s overall shifts, and a conditional PCD …

Changes In Rfi Values Of Omomyid Mandibular Molars In Response To Climatic Shifts, Hannah Vanooteghem

Masters Theses

Molar anatomy reflects the functional demands of food mastication, and dental topography provides a quantitative method for evaluating how molar structure relates to dietary niche. Relief index (RFI), a dental topographic measure, has been successfully used to infer diet in extant and fossil mammals. This study tests two hypotheses regarding mandibular molars of early Eocene omomyids: (1) There is an association between changes in omomyid RFI values of first and second mandibular molars and changes in climatic variables (temperature and precipitation) from Wa0 to Wa5, and (2) The first and second mandibular molar RFI values of omomyid species are significantly …

Classification Of Human Trust In Ai Using Brain Activity Data, Danushka Bandara, Ruhuan Liao, Fatima Chowdhury, Leslie Abbott

Northeast Journal of Complex Systems (NEJCS)

Trust plays a crucial role in human-computer interaction, particularly in scenarios involving artificial intelligence (AI) systems. This study explores the feasibility of using functional near-infrared spectroscopy (fNIRS) data to classify trust levels in human-AI interaction scenarios. A total of 18 participants completed an image classification task with an AI team member while their hemodynamic responses were recorded using fNIRS. Preprocessing of fNIRS data involved motion artifact removal, filtering, and normalization. Exploratory analysis identified significant associations between hemodynamic responses in the prefrontal cortex and trust levels. An across-subject binary trust classification model was developed using machine learning techniques, achieving an F1 …

Modulation Of Pulmonary Epithelial Paracellular Permeability By Pneumolysin From Streptococcus Pneumoniae, Alexandra S. Tamayo Moreira

Biology Theses

Pneumolysin (PLY), a key virulence factor of Streptococcus pneumoniae (S. pneumoniae), disrupts airway epithelial barriers, yet its cellular and molecular mechanisms remain poorly understood. We aim to elucidate recombinant pneumolysin (rPLY)’s effects on Calu-3 bronchial epithelial barrier integrity and underlying pathways. This study investigates the effects of non-lytic and lytic PLY concentrations (5, 15, 30 µg/mL) to test the hypothesis that PLY increases epithelial paracellular permeability by affecting the anatomy and physiology of epithelial tight junctions. To address the hypothesis that PLY increases paracellular permeability through disruption of tight junction integrity in Calu-3 cells in a time- and dose-dependent …

The First Australian Co-Invasion Of Euwallacea Fornicatus, Fusarium Sp. [Af18] And Graphium Euwallaceae, Melinda Moir, Monica Kehoe, Dominie Wright, Stefania Bertazzoni, Peter Scott, Cuiping Wang, Elsie Kinnaird, Brenda A. Coutts

Biosecurity Research Articles

As international trade and travel increase around the world, invasive species detections and incursions are increasing in frequency. Here we document the first detection and incursion within Australia by the Polyphagous shot-hole borer (PSHB), Euwallacea fornicatus (Eichhoff, 1868) (Coleoptera: Curculionidae: Scolytinae), an ambrosia beetle, and two of the associated fungal species; Fusarium sp. [AF18], and Graphium euwallaceae. All three exotic species were detected in a confined region within Perth, Western Australia, and represent a co-invasion. This multispecies incursion into one of the world’s most remote cities highlights the rapid increase in biological invasions globally and the pressures that urban, agricultural, …

Establishing A Novel Neurofunctional Pre-Season Baseline For Sports-Related Concussion In Men And Women Collegiate Athletics, Jonathan C. Vincent, Jon G. Divine Md Ms, Aaron Kuehn-Himmler At Ms, Robert E. Mangine Pt Med Atc, Jim K. Ellis Od, Frederick R. Carrick Dc, Phd, Ms-Hped, Kimberly A. Hasselfeld, Blake M. Bacevich, Daniel Fosselman Do Mba, Joseph F. Clark Phd, Atc

Journal for Sports Neuroscience

Objective: To develop and validate a multi-domain neurofunctional baseline incorporating ocular, vestibular, proprioceptive, and cognitive assessments for collegiate athletes, thereby providing a more comprehensive approach to detecting and managing sports-related concussions.

Design: Retrospective chart review of pre-season baseline data.

Setting: Collegiate athletic training facility.

Participants: A total of 194 Division I collegiate athletes aged 18–24 years, stratified by sport, sex, and self-reported concussion history.

Interventions: A comprehensive battery of clinical and instrument-based neurological assessments, including Dynavision D2 tests (visual-motor coordination and reaction time), stereopsis, convergence, proprioception, peripheral vision, and retinal nerve fiber layer (RNFL) thickness measurements.

Main Outcome Measures: Normative …

The Enigmatic Samuel Aughey: Nebraska’S Pastor Naturalist, Hugh H. Genoways, Margaret R. Bolick, Mary Anne Andrei

Zea E-Books Collection

Samuel Aughey at age 39 became the first Professor of Natural Science at the new University of Nebraska in Lincoln, serving from 1871 to 1883. He was an ordained pastor of the Evangelical Lutheran Church, with an addendum degree from Pennsylvania College (now Gettysburg College) in 1856 and an A.M. degree two years later. His early pastoral work was in Pennsylvania, but in 1864 he became a home missionary to a church in Dakota City, Nebraska. Aughey’s career at the university was marked with successes and honors, but also criticism and questions about his basic knowledge of the sciences. While …

Utilization Of Bixin-Loaded Polycaprolactone Nanoparticles To Ameliorate E-Cigarette-Induced Damage To Human Bronchial Epithelial Cells, Sophia R. Claymore

USF Tampa Graduate Theses and Dissertations

Electronic cigarettes (e-cigs) have increased in popularity and usage over the last few decades. E-cigs are generally composed of a liquid containing nicotine flavoring chemicals, a battery, a vaporization chamber, and a coil that heats the liquid upon inhalation of the mouthpiece. E-cigs were initially introduced as a healthy alternative to cigarette smoking. However, recent research has demonstrated that e-cigs elicit comparable cytotoxic and dangerous effects to conventional cigarettes. Bixin has been introduced in recent research as a candidate for therapeutic applications due to its innate anticancer, antioxidative, and anti-inflammatory characteristics. Nanoparticles (NPs) have emerged over the past few decades …