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The Legacy Of Lead: Lead Exposure's Harmful Effects And Its Concentration In Poc Communities, Layla Sophronia Barber May 2026

The Legacy Of Lead: Lead Exposure's Harmful Effects And Its Concentration In Poc Communities, Layla Sophronia Barber

Student Theses 2015-Present

This thesis examines the disproportionate burden of lead exposure carried by low income, POC communities. The systemic nature of this problem is a symptom of a longstanding legacy of environmental injustice in the United States. Decades of federal neglect are reflected in the higher statistics of lead exposure and poisoning in predominantly black communities. While it is understood that lead exposure poses a serious threat to physical health and early cognitive development, there is a discouraging lack of urgency to remove the toxin from non-wealthy communities. The material covered by this thesis aims to identify and correct the discriminatory social …


Analyzing Sun Bucks Program Experience Among Southwestern Pennsylvania Families With Just Harvest, Olivia Mae Gifford May 2026

Analyzing Sun Bucks Program Experience Among Southwestern Pennsylvania Families With Just Harvest, Olivia Mae Gifford

Public Health Capstone Projects

  1. Objectives: This project primarily seeks to identify the common barriers preventing vulnerable families from accessing the SUN Bucks Program. The SUN Bucks program is an optional program through the United States Department of Agriculture that works in conjunction with the state of Pennsylvania in order to provide school-aged children families with supplemental funds to supply greater nutrition during the summer months. This research supports the work of a local non-profit, Just Harvest, in order to better inform their advocacy and outreach efforts as they fight against food insecurity in Western Pennsylvania.
  2. Methods: All data was collected electronically via a …


Soil Conditions Impacting Geothermal Plant Communities In Yellowstone National Park, Karina Nordwald May 2026

Soil Conditions Impacting Geothermal Plant Communities In Yellowstone National Park, Karina Nordwald

Honors Theses

Soil acts as the foundation for a productive and functioning environment, by supporting plant life. Abiotic factors drive soil health and consequently influence vegetation. Geothermal activity affects vegetation through strong environmental filters from harsh conditions. Hydrothermal features in Yellowstone National Park represent a variety of naturally occurring extreme environments, where each hot spring ranges in temperature, pH, and overall chemical composition. This study investigates how these environmental drivers dictate vegetation communities, by focusing on the transition zones between geothermal activity and distance from the feature that moves toward increasingly “favorable” environments. By observing a variety of features throughout Yellowstone, we …


Debriefing In Emergency Departments And Intensive Care Units To Combat Compassion Fatigue, Madison N. Chiolino May 2026

Debriefing In Emergency Departments And Intensive Care Units To Combat Compassion Fatigue, Madison N. Chiolino

ATU Theses and Dissertations 2021 - Present

Compassion fatigue can be associated with nurses working in increased stressful environments such as the Intensive Care Unit (ICU) and Emergency Room (ER).  There is a gap in healthcare facilities, where structured interventions like debriefing tools are not implemented to address compassion fatigue. The purpose of this study was to determine if implementing a debriefing tool in areas where nurses are placed in high stress scenarios such as the intensive care unit and emergency department can aid in combating compassion fatigue. A piloted quantitative pre-and post-survey intervention design was used. Data was collected using the ProQOL 5 and PEARLS debriefing …


Impacts Of Salinity On Microbial Enzyme Activity In Coastal Waters, Natali Ariyoshi May 2026

Impacts Of Salinity On Microbial Enzyme Activity In Coastal Waters, Natali Ariyoshi

Honors Theses

Microbial extracellular enzymes are critical for the breakdown of organic matter and nutrient cycling in aquatic ecosystems. Extracellular enzyme activity serves as an indicator of nutrient turnover rates, metabolic states, and nutrient limitations within an ecosystem. Coastal ecosystems are especially dynamic as the influx of freshwater from inland runoff or seawater intrusion from storm surges can lead to fluctuations in salinity which can restructure microbial communities and alter enzymatic activity. Despite the ecological significance of these changes, few studies have explored the effects of short-term salinity shifts on microbial extracellular enzyme activity in coastal waters. This study investigated the effects …


Effects Of Increased Salinity On Mississippi Coast Bacterial Community Composition And Diversity, Clifton C. Wade May 2026

Effects Of Increased Salinity On Mississippi Coast Bacterial Community Composition And Diversity, Clifton C. Wade

Honors Theses

Bacterial communities are important to ecosystem function in coastal environments, but the response of these communities to short term increased salinity conditions is understudied. This study utilized a microcosm setup to investigate the response of coastal seawater bacterial communities to three treatments: an unamended seawater control, a reference treatment that received reverse osmosis (RO) water, and an elevated salinity treatment that received artificial seawater dissolved in RO water. Microcosms were sampled four times over a five-day period to analyze the effects of time under different salinity conditions on the seawater bacterial community. 16S rRNA gene sequencing was used to analyze …


Service-Learning In Adapted Physical Activity: Student Experiences With And Without Course Integration, Courtney Jost, Nicole Fiscella Nicole Fiscella, Roxanne Bahn-Bales, Tze-Hsuan Wang, Jennifer Beamer, Jennifer Taylor, Willie Chun Wai Leung May 2026

Service-Learning In Adapted Physical Activity: Student Experiences With And Without Course Integration, Courtney Jost, Nicole Fiscella Nicole Fiscella, Roxanne Bahn-Bales, Tze-Hsuan Wang, Jennifer Beamer, Jennifer Taylor, Willie Chun Wai Leung

Educational Practices in Kinesiology

Service-learning is widely used in adapted physical activity/education (APA/APE) courses to enhance student learning through community engagement. However, limited research has explored how the presence or absence of an APA/APE course influences students’ perceived learning, confidence, and engagement in inclusive physical activity settings. This quasi-experimental, cross-sectional study examined how course-enhanced and purely experiential models of a university-based APA service-learning program, PA PALS, shaped undergraduate students’ experiences. Students (N = 58) participated; 41.4% (n = 24) were concurrently enrolled in an APA/APE course (course-enhanced group), while 58.6% (n = 34) participated as volunteers (purely experiential group). A validated …


Bax Activation Through The N-Terminal Bh3-Like Domains Of Vdac1 And Vdac2, Autumn A. Peters May 2026

Bax Activation Through The N-Terminal Bh3-Like Domains Of Vdac1 And Vdac2, Autumn A. Peters

Honors Theses

Voltage-dependent anion channels (VDACs) are central to mitochondrial function by mediating metabolite diffusion across the mitochondrial outer membrane (MOM). Two isoforms­­­­­­­­­­­,­­­­­­­­­­­­­­­­­­­­­­­­­­­­ VDACs 1 and 2, are also implicated in apoptosis based on interactions with Bcl-2 family proteins that control this process, including Bax and Bcl-xL. Activation of the pro-apoptotic protein Bax by interaction with ‘BH3-only’ proteins, such as Bim or Bid, induces MOM permeabilization to signal apoptosis, yet accumulating evidence indicates VDACs 1 and 2 may also affect Bax. We discovered that the VDAC N-terminal domains contain high sequence similarity to the conserved BH3 domains within Bcl-2 family members that …


Challenges And Innovations In Tennis Coach Development: International Insights From Practitioners Across Continents, Miguel Crespo, Rafael Martinez-Gallego, Christine Nash May 2026

Challenges And Innovations In Tennis Coach Development: International Insights From Practitioners Across Continents, Miguel Crespo, Rafael Martinez-Gallego, Christine Nash

Journal of Coach Development

Tennis is a global sport with effective coaches being essential to the continued appeal, therefore the work of the coach developers within the International Tennis Federation (ITF) is crucial. This research examined the work and aspirations of coach developers in tennis using in-depth interviews with 10 ITF coach developers. Subsequently, we developed detailed pen portraits of two ITF coach developers at different levels of experience and engagement in order to highlight any differences in work, objectives or ambition. Findings from coach developers revealed three themes: support from ITF; barriers to learning; making learning less traditional. The pen portraits added further …


Clethra Alnifolia: A Fact Sheet For Seed Transfer Considerations, Taylor Houggy May 2026

Clethra Alnifolia: A Fact Sheet For Seed Transfer Considerations, Taylor Houggy

Plant Science Articles

Clethra alnifolia is a highly prized fragrant deciduous shrub, often found in many home gardens across Eastern North America. Despite its popularity in the landscape industry, there is little research comparing C. alnifolia's natural habits in the wild to its habits as a landscaped cultivar. Information such as flowering phenology, genetic diversity, and growth habits have the potential to change considerably depending on C. alnifolia's location. Because of this, it is important that landscape growers as well as forest conservationists have access to ecological fact sheets in order to make informed decisions when transferring seed to different areas. In this …


Invasive Macrofungi In The United States: A Mushrooming Crisis, Emily Torres May 2026

Invasive Macrofungi In The United States: A Mushrooming Crisis, Emily Torres

Student Theses 2015-Present

Globalization has accelerated the spread of invasive species, making them one of the largest contributors to biodiversity loss worldwide. While invasive macrofungi remain largely absent from scientific discourse on invasive species, they represent a growing ecological concern throughout the United States. Invasive macrofungi disrupt forest ecosystems, alter soil communities, and displace native fungi. Beyond these ecological impacts, their presence and establishment profoundly affect human-nature relationships, most notably mushroom foraging and cultivation practices. This paper adopts a multidisciplinary approach to examine the ecological, economic, and anthropogenic impacts of invasive macrofungi in the United States. Chapter 1 provides a quantitative overview of …


Effect Of Accelerated Adaptation Programs On Feedlot Performance And Health Of Steers Drenched With Megasphaera Elsdenii And Quantifying And Partitioning Multi-Year Carbon Dioxide And Methane Fluxes In A Grazed Temperate Pasture, Rebecca Mcdermott May 2026

Effect Of Accelerated Adaptation Programs On Feedlot Performance And Health Of Steers Drenched With Megasphaera Elsdenii And Quantifying And Partitioning Multi-Year Carbon Dioxide And Methane Fluxes In A Grazed Temperate Pasture, Rebecca Mcdermott

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

With strong consumer demand for beef and increasing concern about the environmental impacts of beef production, improving production efficiency and advancing the understanding of the environmental footprint are critical for the long-term sustainability of beef production systems. The first experiment evaluated the effect of accelerated adaptation strategies, using energy intake and cattle behavior, on feedlot performance, carcass characteristics, and health of yearling steers drenched with exogenous Megasphaera elsdenii. Accelerated adaptation programs (0, 7, or 14 d transition to 100% finisher) were compared to a traditional 21-d adaptation. Dry matter intake responded quadratically across treatments, with the greatest intake observed in …


Faith, Science, And Choice: Vaccine Attitudes Among Religious University Students, Jamie Jensen May 2026

Faith, Science, And Choice: Vaccine Attitudes Among Religious University Students, Jamie Jensen

ScholarsArchive Data

These data comprise a Q-methodology study conducted at Brigham Young University among undergraduate students to determine vaccine attitudes in relation to religious and political ideologies. It includes raw sort data, templates for running Q-methodology, and interview transcripts.


Attentional Mechanisms Of Language In Infants With Down Syndrome, Fragile X Syndrome And Siblings Of Children With Autism, Isabelle Robinson May 2026

Attentional Mechanisms Of Language In Infants With Down Syndrome, Fragile X Syndrome And Siblings Of Children With Autism, Isabelle Robinson

Caravel Undergraduate Research Journal

Children with Down syndrome (DS), fragile X syndrome (FXS), or younger siblings of a child with autism spectrum disorder (ASIB) often exhibit atypical object exploration and social engagement, which can affect important learning opportunities. The purpose of this study was to examine group differences in social attention shifting and attentional disengagement between infants with DS, FXS, and ASIBs. This study utilized data from a longitudinal study collected from 12-month-old infants with DS (n = 13), FXS (n = 14), and ASIBs (n = 24). No group differences were seen for social attention shifting. However, infants with DS …


Examining Biobehavioral Indicators Of Adhd In Children With Fxs, Hannah Pressler, Kayla Smith, Ramsey Coyle, Elizabeth Will, Jane E. Roberts May 2026

Examining Biobehavioral Indicators Of Adhd In Children With Fxs, Hannah Pressler, Kayla Smith, Ramsey Coyle, Elizabeth Will, Jane E. Roberts

Caravel Undergraduate Research Journal

Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by inattention and hyperactivity/impulsivity behaviors that are inconsistent with developmental age. Children with fragile X syndrome (FXS), a genetic neurodevelopmental disorder, are often diagnosed with comorbid ADHD (53–59% of males with FXS). Despite the prevalence of ADHD in FXS, little is known about the early manifestation of ADHD. The current project aims to explore group differences in play behaviors between children with FXS and typically developing (TD) children as well as the relationship between infant play behavior and heart activity to future ADHD attention outcomes. Participants included male children with FXS and …


The Universe Under A Microscope, Claire Chabot May 2026

The Universe Under A Microscope, Claire Chabot

Caravel Undergraduate Research Journal

No abstract provided.


Early Behavioral And Physiological Predictors Of Autism In 12-Month-Old Siblings Of Children With Autism, Nicolas Poupore, Kayla Smith, Abigail L. Hogan, Jane E. Roberts Ph.D. May 2026

Early Behavioral And Physiological Predictors Of Autism In 12-Month-Old Siblings Of Children With Autism, Nicolas Poupore, Kayla Smith, Abigail L. Hogan, Jane E. Roberts Ph.D.

Caravel Undergraduate Research Journal

Autism spectrum disorder (ASD) is a neurodevelopmental disorder defined by social-communicative deficits and repetitive behaviors. Complementing behavioral (i.e., The Autism Observation Scale for Infants (AOSI) scores) and physiological markers (i.e., respiratory sinus arrhythmia (RSA), heart rate (HR)) may improve early identification of ASD and provide insights into the neurobiological mechanisms contributing to early ASD symptoms. Younger siblings of a child with ASD (ASIBs) had significantly higher AOSI Total Scores and AOSI Marker Scores in comparison to Low Risk Controls (LRCs). RSA significantly decreased from a Baseline to AOSI for both groups, but only for the ASIB group was a negative …


A Review Of Video Game Effects And Uses, David Corso May 2026

A Review Of Video Game Effects And Uses, David Corso

Caravel Undergraduate Research Journal

Video games are versatile in their form and function. Whether they’re training doctors or offsetting Alzheimer’s disease, video games can exercise both mental and physical features, train specific skills for a number of jobs, educate players about events and phenomenon in our world, research and understand natural human processes, and they can be designed for a number of other purposes. Multiple studies have demonstrated the effects of video games on physiological and cognitive levels—positive, negative, and everything in between. This paper identifies various physical and psychological effects that video games produce, and it suggests ways in which video games can …


Exploring Microbiome Communities Of Two Belize Coral Species Five Years After Reciprocal Transplant, Lily E. Kratz May 2026

Exploring Microbiome Communities Of Two Belize Coral Species Five Years After Reciprocal Transplant, Lily E. Kratz

Biology Honors Papers

Coral holobionts, which include the coral animal host, dinoflagellate algae, bacteria, etc., support coral reef biodiversity by providing habitat to many marine species. In the face of global change, identifying and understanding the microbial diversity of corals is extremely important because their survival indicates overall ocean health. Coral-associated bacterial and algal communities contribute to the health and survival of a coral species through creating resistance to stressors and supplying essential nutrients. As coral reef environments continue to change, microbial communities must respond to ensure the survival of reef-building corals. To investigate if coral microbiomes possess the ability to acclimatize to …


Bats In A Modified Suburban Landscape, Brittany Morgera May 2026

Bats In A Modified Suburban Landscape, Brittany Morgera

Biology Honors Papers

This research assesses bat species richness and activity across a gradient of suburban habitat modification surrounding Ursinus College and Green Lane Park in Montgomery County, located in southeastern Pennsylvania. Habitat modification was quantified using GIS-based land-cover metrics (e.g. impervious surfaces and canopy cover), and bat activity and species richness were measured though acoustic surveys conducted at 15 sites during the summers of 2024 and 2025. The project tests the hypothesis that increasing habitat modification has a negative correlation with bat species richness and activity.


Neural Mechanisms Underlying Jung’S Active Imagination: A Review And Hypothesis, Charles R. Fox May 2026

Neural Mechanisms Underlying Jung’S Active Imagination: A Review And Hypothesis, Charles R. Fox

Journal of Conscious Evolution

Active imagination is a key technique of Jungian analysis. Despite its centrality, and its potential importance beyond Jungian psychology to the area of systems neuroscience, psychology, and consciousness studies, there are no known neurological mechanisms underlying this psychological phenomenon. There is a history of using the types of mental imagery used in active imagination to explore consciousness. The development and use of active imagination is briefly reviewed, and a case is developed that the neurology underlying active imagination would be fruitfully explored by considering it a special case of mystical experience. Active imagination primarily uses the right hemisphere processing of …


Prevalence, Determinants, And Objective Risk Of Unintentional Therapeutic Duplication Among Adults In Saudi Arabia, Yosra Alhindi May 2026

Prevalence, Determinants, And Objective Risk Of Unintentional Therapeutic Duplication Among Adults In Saudi Arabia, Yosra Alhindi

Saudi Toxicology Journal

Background: Unintentional therapeutic duplication represents an underrecognized yet preventable contributor to medication-related harm, particularly in settings characterized by widespread over-the-counter (OTC) medicine use and self-medication practices. Objective: To estimate the prevalence of unintentional therapeutic duplication among adults in Saudi Arabia and identify sociodemographic and behavioral predictors associated with increased therapeutic duplication risk. Methods: A national crosssectional study was conducted between February 10 and April 28, 2025, using a structured, self-administered online questionnaire distributed via social media platforms. The survey assessed sociodemographic characteristics, medication-use behaviors, active-ingredient literacy, and duplication risk using both self-reported measures and scenario-based assessments. Multivariable logistic regression was …


Examining The Influences Of Citizen Factors On The Co-Creation Behaviors Of Online Public Services In A Smart City, Ratih Dyah Kusumastuti, Nurmala Nurmala, Juliana Rouli May 2026

Examining The Influences Of Citizen Factors On The Co-Creation Behaviors Of Online Public Services In A Smart City, Ratih Dyah Kusumastuti, Nurmala Nurmala, Juliana Rouli

Journal of Environmental Science and Sustainable Development

As smart cities increasingly rely on digital platforms to deliver public services, citizen participation becomes essential for ensuring effective and sustainable service delivery. However, limited research has examined which citizen-related factors drive co-creation behaviors in smart city contexts, particularly in emerging economies. This study aims to investigate the factors that influence the co-creation behaviors of online public services in five smart cities in Indonesia through the city’s digital platform and online social network (OSN). This study analyzes whether citizen factors, namely, perceived benefits over the city and OSN friends, trust in the city and OSN friends, and self-efficacy, affect co-creation …


Navigating The Genetic Frontier: Clinical And Ethical Implications Of Free Genetic Testing In India, Preetha Vijayalakshmi May 2026

Navigating The Genetic Frontier: Clinical And Ethical Implications Of Free Genetic Testing In India, Preetha Vijayalakshmi

Journal Of Indian Physician Associates

The expansion of free genetic testing services in India, resulting from government policies like the Ayushman Bharat Digital Mission, corporate-sponsored initiatives, and international collaborations, makes it easier to access genomic services for early identification of inherited disorders such as thalassemia, sickle cell anemia, and certain genetic kidney diseases, particularly in tribal populations. However, this review reveals significant clinical and ethical challenges. Clinically, Western-based genotyping platforms, not tailored to India’s genetic diversity, risk inaccurate results, including false positives and negatives, complicating clinical decision-making. A shortage of genetic counsellors and inadequate post-test care leaves patients, especially in rural areas, struggling within fragmented …


A Jobs-To-Be-Done Framework For Mapping Digital Innovation Opportunities In Climate-Smart Agrifood Systems, Lourival Carmo Monaco Neto, Allan Gray May 2026

A Jobs-To-Be-Done Framework For Mapping Digital Innovation Opportunities In Climate-Smart Agrifood Systems, Lourival Carmo Monaco Neto, Allan Gray

Department of Agricultural Economics Faculty Publications

The agrifood sector faces well-documented barriers to climate-smart agriculture (CSA) adoption, reflecting systematic difficulty identifying where digital tools address specific stakeholder needs rather than a technology shortage. This paper presents a prescriptive framework for mapping digital innovation opportunities in complex, multi-stakeholder agrifood systems. Grounded in Jobs-to-be-Done (JTBD) theory and structured as a two-dimensional matrix of meta-jobs and value chain segments, the framework was developed through a design science research (DSR) paradigm evaluated on utility, coherence, and actionability. Construction involved a purposive synthesis of three literature streams and iterative refinement through 136 stakeholder engagements within a six-month university-affiliated startup studio cycle. …


Factors Associated With Stunting And Underweight Indices Among Children 0–3 Years In Nairobi, Kenya: A Cross-Sectional Study, Eunice Njoroge, Kevinson Mwangi, Esther Chongwo, Martha Kaniala, Kevin Wekesa, Isaac Lihanda, Vibian Angweny, Rachel Odhiambo, Margaret Kabue, Japhet Adina, Amina Abubakar May 2026

Factors Associated With Stunting And Underweight Indices Among Children 0–3 Years In Nairobi, Kenya: A Cross-Sectional Study, Eunice Njoroge, Kevinson Mwangi, Esther Chongwo, Martha Kaniala, Kevin Wekesa, Isaac Lihanda, Vibian Angweny, Rachel Odhiambo, Margaret Kabue, Japhet Adina, Amina Abubakar

Institute for Human Development, East Africa

Background:Childundernutritionremainsoneofthemostpressingglobalpublic health challenges, particularly in low and middle-income countries (LMICs). Most studies focus broadly on children under five, potentially overlooking the unique vulnerabilities a ecting children in the first 1,000 days of life. This study investigated potential factors associated with stunting and underweight malnutritional presentation among children aged 0–3 years in Nairobi City County, Kenya.

Methods: We conducted a cross-sectional study of 2903 caregiver-child dyads living in Nairobi City County to assess stunting [Height-for-Age Z-scores (HAZ)] and underweight [Weight-for-Age Z-scores (WAZ)] using the World Health Organisation (WHO) growth standards among 0–3-year-olds. Child, caregiver, and householdcharacteristicswereincludedinthelinearmixede ects regression models …


Consumerism In The Digital Age: Environmental And Cultural Consequences, Danielle Andrea Montoya May 2026

Consumerism In The Digital Age: Environmental And Cultural Consequences, Danielle Andrea Montoya

Student Theses 2015-Present

Overconsumption has emerged as a significant environmental problem, characterized by persistent patterns of buying, using, and discarding goods at rates that exceed ecological limits. In the digital age, these patterns of consumption are reinforced by economic systems, technological advancements, and cultural norms that make constant consumption feel normal and convenient. While consumption is necessary for everyday life, consumption beyond basic needs contributes to increased waste, resource depletion, pollution, and climate change. Overconsumption is embedded in daily habits such as online shopping, food consumption, and frequent product replacement. Therefore, understanding and addressing overconsumption is crucial for achieving environmental sustainability and social …


The Evaluation Of Broiler Lines Divergently Selected For Water Conversion Ratio Under Acute And Chronic Stress, Baileigh B. Cash May 2026

The Evaluation Of Broiler Lines Divergently Selected For Water Conversion Ratio Under Acute And Chronic Stress, Baileigh B. Cash

Poultry Science Undergraduate Honors Theses

            The importance of water conversion ratio in broiler production influences not only bird physiology but also barn environment, litter quality, and provides potential solutions to environmental stressors. However, very little is known about how genetic selection for water conversion ratio can affect litter characteristics and performance parameters, specifically under heat stress conditions. This study evaluates the effects of genetic lines, environmental conditions, and time, on litter and bird performance characteristics in high water conversion ratio (HWCR) and low water conversion ratio (LWCR) broilers. Litter samples were collected from HWCR and LWCR broilers raised under heat-stress and thermal-neutral conditions, both before …


The Effects Of Avian Influenza On Consumer Egg Prices In The United States, Jacob B. Franklin May 2026

The Effects Of Avian Influenza On Consumer Egg Prices In The United States, Jacob B. Franklin

Agricultural Economics and Agribusiness Undergraduate Honors Theses

Outbreaks of highly pathogenic avian influenza (HPAI) create major challenges to poultry supply chains due to the high mortality rates in flocks, leading to disruptions in production and higher costs for producers. Using quantitative data from Federal Reserve Bank of St. Louis, USDA, and National Agricultural Statistics Service, this research analyzes changes in egg production, retail prices, and regional variations throughout the United States for the 2022-2025 HPAI event. A time-series regression model was used to control for production costs, seasonal patterns, and regional differences. All of these measures come together to quantify the impact of HPAI outbreaks on consumer …


From Chaos To Clockwork: Investigating The Role Of Circadian Genes In Metabolic Development Of 2nd And 3rd Instar Drosophila Larvae, Elliott R. Ruegsegger, Stephanie Hood, Amy Poe May 2026

From Chaos To Clockwork: Investigating The Role Of Circadian Genes In Metabolic Development Of 2nd And 3rd Instar Drosophila Larvae, Elliott R. Ruegsegger, Stephanie Hood, Amy Poe

Biological Sciences Undergraduate Honors Theses

Circadian clocks regulate daily physiological and metabolic rhythms across many organisms. In Drosophila melanogaster, the molecular clock involving period (per) and timeless regulates gene expression across 24-hour cycles. Circadian rhythms are well characterized in adult, mature organisms, but their emergence during early developmental stages remain poorly understood. In D. melanogaster, the circadian regulation of sleep and feeding rhythms emerges during the 3rd instar larval stage. This suggests that the circadian regulation of metabolism may also arise during this stage. Further, the metabolic consequences of circadian clock disruptions during this developmentally rich period remain unclear. This research aimed to …