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Full-Text Articles in Entire DC Network
Pilot Study: Integrating The Epic Stroke Narrator Into Inpatient Code Stroke Protocols To Improve Symptom Onset Identification And Reduce Intervention Times, Stacy L. Carter
Doctoral Dissertations and Projects
In-hospital strokes are often underrecognized, leading to treatment delays and poorer outcomes compared to community-onset strokes. This scholarly project evaluated whether integrating the Epic Stroke Narrator into inpatient code stroke protocols could improve documentation of last known well time (LKWT) and reduce time to intervention. A 6-week quasi-experimental pilot study guided by the Iowa Model of Evidence-Based Practice and Rogers’ diffusion of innovations theory was conducted on a neuroscience telemetry step-down unit at a comprehensive stroke center in Richmond, Virginia. Education on the Stroke Narrator was provided to bedside nurses and was followed by implementation and evaluation of narrator use …
Bacterial Identification, Antibiotic Susceptibility Testing (Ast), And Epstein-Barr Virus (Ebv) Testing To Increase Organ Transplantation Within A Western Regional Community, Vedarrius D. Williams
Bacterial Identification, Antibiotic Susceptibility Testing (Ast), And Epstein-Barr Virus (Ebv) Testing To Increase Organ Transplantation Within A Western Regional Community, Vedarrius D. Williams
Doctoral Dissertations and Projects
Clinical transplantation demands have increased immensely in recent years and, along with increasing supply shortages, many barriers to successful organ donation arise from a lack of dedicated testing to rule out microbial or bloodborne infections. There are currently minimal, federal regulatory requirements for transplantation specimen testing. The purpose of this study is to explore how to increase the viability and success of transplantations in the Western regions of the United States using kidney, pancreas, and kidney/pancreas transplant data from University Medical Center Southern Nevada (UMCSN) transplant center. UMCSN transplant center and Donor Services Laboratory (DSL) in Las Vegas perform bacterial …
Implementation Evaluation Of Blood Flow Restriction In The Rehabilitative Setting, Corbit Franks, Madison Wellborn, Matthew A. Chatlaong, Daphney M. Carter, William M. Miller, Matthew B. Jessee, Robert E. Davis
Implementation Evaluation Of Blood Flow Restriction In The Rehabilitative Setting, Corbit Franks, Madison Wellborn, Matthew A. Chatlaong, Daphney M. Carter, William M. Miller, Matthew B. Jessee, Robert E. Davis
Internet Journal of Allied Health Sciences and Practice
Purpose: Blood flow restriction refers to a training/rehabilitation method consisting of an external pressure system applied to a limb to partially inhibit blood flow to the tissues. Though much research has been conducted concerning the use of blood flow restriction, there is limited research concerning why clinicians may or may not utilize it. Objective: The current qualitative study utilized the Consolidated Framework for Implementation Research to investigate why clinicians may or may not implement blood flow restriction in the clinical setting. Methods: A semi-structured interview addressing twelve implementation constructs within four domains (Intervention Characteristics, Outer Setting, Inner Setting, and Characteristics …
Structural Analysis And Functional Prediction Of Prgr , A Target Protein Of The Poria Ergosta- 7,22e-Dien- 3Β-Ol, Yongfei Liu, Yanling Ren, Tao Wang, Maozhao Wu, Jing Peng, Changyun Wu, Zexiu Li
Structural Analysis And Functional Prediction Of Prgr , A Target Protein Of The Poria Ergosta- 7,22e-Dien- 3Β-Ol, Yongfei Liu, Yanling Ren, Tao Wang, Maozhao Wu, Jing Peng, Changyun Wu, Zexiu Li
Journal of Food Science and Biotechnology
[Objective ] This study aims to investigate the mechanism of the interaction between ergosta- 7,22E-dien- 3β-ol,an active sterol of Poria,and progesterone receptor (PRGR ) and the potential therapeutic effects via bioinformatics and molecular docking.[Method ] The TCMSP database was used to screen the active ingredients of Poria,and MEGA X (10.0.5) was used for alignment of multiple PRGR sequences.The primary structure of PRGR was analyzed by ProtParam,and the hydrophobicity of PRGR was predicted by Protscale.The amino acid sequence of PRGR was analyzed by Prosite,and the secondary structure of PRGR was analyzed on [email protected] RCSB PDB database was used to predict the …
Managing User Conflicts In A Water Aerobics Program On Behalf Of A Veteran’S Group: A Short Case Study, Hadley Blankenship, Steven N. Waller Ph.D., Jason L. Scott
Managing User Conflicts In A Water Aerobics Program On Behalf Of A Veteran’S Group: A Short Case Study, Hadley Blankenship, Steven N. Waller Ph.D., Jason L. Scott
International Journal of Aquatic Research and Education
This article captures an experience in conflict management that happened during the summer of 2024 as a recreational therapy intern with an adaptive sport and recreation organization located in the Southeastern United States. The backdrop to the case is that a recreational therapy intern worked with various special needs populations – mainly with paraplegic (adult and youth) athletes and veterans. In many organizations, user conflicts and poor communication regarding service provision and scheduling hinder the implementation of programs for special populations, such as veteran groups. In this case, a problem occurred with the scheduling of a water aerobics program for …
Curbing Fatal And Non-Fatal Drowning Deaths: An Effort To Reach Under-Resourced Children In Baltimore, Maryland, Ashton P. Christo, William D. Ramos
Curbing Fatal And Non-Fatal Drowning Deaths: An Effort To Reach Under-Resourced Children In Baltimore, Maryland, Ashton P. Christo, William D. Ramos
International Journal of Aquatic Research and Education
Drowning remains a significant public health problem in the United States, with The Centers for Disease Control and Prevention (CDC) reporting approximately 4,000 drowning deaths annually. Children aged 1-4 face the highest risk, and African American children are disproportionately affected–7.6 times more likely to drown than white children (CDC, 2024). In a city on the East Coast that is predominantly African American, limited access to swimming lessons heightens the risk. To reduce drowning rates, a collaborative swimming program was established between a city high school and a public school enrichment program. The initiative provided essential water safety and swimming skills …
Diversity In Aquatics:4th Special Issue, Tiffany M. Quash Ph.D., Angela K. Beale-Tawfeeq, Steven N. Waller Ph.D.
Diversity In Aquatics:4th Special Issue, Tiffany M. Quash Ph.D., Angela K. Beale-Tawfeeq, Steven N. Waller Ph.D.
International Journal of Aquatic Research and Education
The theme of this special issue is “Building a Community of Champions.” The purpose of this theme is to highlight and promote a civic engagement perspective that engages, advocates, and supports communities of Black, Indigenous, People of Color (BIPOC) in addressing the national, regional, and local evolving health-related issue of drowning. Aquatic Settings have been a pivotal focal point of social justice, water safety, and public health, not only in the past but also in our present day (Beale-Tawfeeq, Quash, et al, 2023 and Waller and Bemiller, 2023). Diversity In Aquatics (DIA) strives to positively impact the field of aquatics …
Teaching Swimming To Children With Disabilities: A Qualitative Analysis Of Swim Instructorstea, Stephanie S. Garcia-Hidalgo, Martin E. Block
Teaching Swimming To Children With Disabilities: A Qualitative Analysis Of Swim Instructorstea, Stephanie S. Garcia-Hidalgo, Martin E. Block
International Journal of Aquatic Research and Education
When teaching children with disabilities, swim instructors need to be able to assess the unique strengths and needs of each child to determine modifications needed to instruction, equipment, and the setting and then be flexible enough to make changes in real-time to ensure success for the child. Unfortunately, many swim instructors only work seasonally and have the occasional child with a disability, and as a result are likely to have limited training and experiences with children with disabilities. The purpose of this pilot qualitative study is to examine backgrounds, training, and experiences of six swim instructors who work with children …
Effects Of Critical Environmental Factors On The Antimicrobial Activity Of Ε-Poly- L-Lysine, Zhenjie Liu, Peihao Huang, Shu Chen, Shun Rong, Feiting Peng, Ling Chen, Weipeng Guo
Effects Of Critical Environmental Factors On The Antimicrobial Activity Of Ε-Poly- L-Lysine, Zhenjie Liu, Peihao Huang, Shu Chen, Shun Rong, Feiting Peng, Ling Chen, Weipeng Guo
Journal of Food Science and Biotechnology
[Objective ] This study explored the effects of critical environmental factors [water activity (aw),pH,and temperature ] on the antimicrobial activity of ε-poly- L-lysine (ε-PL),aiming to provide a basis for the application of ε-PL.[Method ] With Staphylococcus aureus as an indicator strain,the micro-broth dilution and agar dilution methods as well as antimicrobial growth kinetics were utilized to determine the antimicrobial activity of ε-PL.The protein leakage assay was employed to evaluate the bacterial membrane disruption activity of ε-PL.Live/Dead fluorescence staining was performed to observe the bacterial membrane permeability.[Result ] The minimum inhibitory mass concentration (MIC ) of ε-PL against Staphylococcus aureus was …
Introducing Mcodegpt As A Zero-Shot Information Extraction From Clinical Free Text Data Tool For Cancer Research, Kai Zhang, Tongtong Huang, Bradley A Malin, Travis Osterman, Qi Long, Xiaoqian Jiang
Introducing Mcodegpt As A Zero-Shot Information Extraction From Clinical Free Text Data Tool For Cancer Research, Kai Zhang, Tongtong Huang, Bradley A Malin, Travis Osterman, Qi Long, Xiaoqian Jiang
Faculty, Staff and Student Publications
Background: The vast amount of natural language clinical notes about patients with cancer presents a challenge for efficient information extraction, standardization, and structuring. Traditional NLP methods require extensive annotation by domain experts for each type of named entity and necessitate model training, highlighting the need for an efficient and accurate extraction method.
Methods: This study introduces a tool based on the Large Language Model (LLM) for zero-shot information extraction from cancer-related clinical notes into structured data aligned with the minimal Common Oncology Data Elements (mCODE™) structure. We utilize the zero-shot learning capabilities of LLMs for information extraction, eliminating the need …
Stereoelectroencephalography Reveals Neural Signatures Of Multisensory Integration In The Human Superior Temporal Sulcus During Audiovisual Speech Perception, Yue Zhang, John F Magnotti, Xiang Zhang, Zhengjia Wang, Yingjia Yu, Kathryn A Davis, Sameer A Sheth, H Isaac Chen, Daniel Yoshor, Michael S Beauchamp
Stereoelectroencephalography Reveals Neural Signatures Of Multisensory Integration In The Human Superior Temporal Sulcus During Audiovisual Speech Perception, Yue Zhang, John F Magnotti, Xiang Zhang, Zhengjia Wang, Yingjia Yu, Kathryn A Davis, Sameer A Sheth, H Isaac Chen, Daniel Yoshor, Michael S Beauchamp
Faculty, Staff and Students Publications
Human speech perception is multisensory, integrating auditory information from the talker's voice with visual information from the talker's face. BOLD fMRI studies have implicated the superior temporal gyrus (STG) in processing auditory speech and the superior temporal sulcus (STS) in integrating auditory and visual speech, but as an indirect hemodynamic measure, fMRI is limited in its ability to track the rapid neural computations underlying speech perception. Using stereoelectroencephalography (sEEG) electrodes, we directly recorded from the STG and STS in 42 epilepsy patients (25F, 17M). Participants identified single words presented in auditory, visual, and audiovisual formats with and without added auditory …
Preoperative Brain Mapping Predicts Language Outcomes After Eloquent Tumor Resection, Matthew T Muir, Kyle Noll, Sarah Prinsloo, Hayley Michener, Jeffrey I Traylor, Vinodh A Kumar, Chibawanye I Ene, Sherise Ferguson, Ho-Ling Liu, Jeffrey S Weinberg, Frederick Lang, Brian A Taylor, Stephanie J Forkel, Sujit S Prabhu
Preoperative Brain Mapping Predicts Language Outcomes After Eloquent Tumor Resection, Matthew T Muir, Kyle Noll, Sarah Prinsloo, Hayley Michener, Jeffrey I Traylor, Vinodh A Kumar, Chibawanye I Ene, Sherise Ferguson, Ho-Ling Liu, Jeffrey S Weinberg, Frederick Lang, Brian A Taylor, Stephanie J Forkel, Sujit S Prabhu
Faculty, Staff and Student Publications
When operating on gliomas near critical language regions, surgeons risk either leaving residual tumor or inducing permanent postoperative language deficits (PLDs). Despite the advent of intraoperative mapping techniques, subjective judgments frequently determine important surgical decisions. We aim to inform data-driven surgery by constructing a non-invasive mapping approach that quantitatively predicts the impact of individual surgical decisions on long-term language function. This study included 79 consecutive patients undergoing resection of language-eloquent gliomas. Patients underwent preoperative navigated transcranial magnetic stimulation (TMS) language mapping to identify language-positive sites ("TMS points") and their associated white matter tracts ("TMS tracts") as well as formal language …
The Isolation And Dna Extraction Of Phytophthora From Four Wildland Soil Types In Northern California, Humboldt County, Angelina Lasko, Christopher Lee, David S. Baston, Susan E. Marshall
The Isolation And Dna Extraction Of Phytophthora From Four Wildland Soil Types In Northern California, Humboldt County, Angelina Lasko, Christopher Lee, David S. Baston, Susan E. Marshall
Creative Publications and Manuals
Phytophthora species are of global importance (Sinclair and Lyon, 2005). For most Phytophthora species, the natural mechanism of how these pathogens travel and spread long distances is not fully understood. They are have been shown to travel by air, water, nursery stock, and via inadvertent human transport. The purpose of this study was to identify the presence of Phytophthora species in four different Northern California forest/wildland soil types. Soils from Franciscan complex parent material (riparian, mixed conifer, and oak woodland), and serpentine parent material (mixed conifer) were sampled in Humboldt County (Fig 1). Phytophthora and other pathogens were baited from …
Quantifying Interest In And Sentiment Of Online Media About Greenhouse Gas Emissions From Cattle Production In The United States, Michael L. Smith, Jinho Jung, Nicole Olynk Widmar, Danielle J. Ufer, Maria Berikou, Jayson Lusk
Quantifying Interest In And Sentiment Of Online Media About Greenhouse Gas Emissions From Cattle Production In The United States, Michael L. Smith, Jinho Jung, Nicole Olynk Widmar, Danielle J. Ufer, Maria Berikou, Jayson Lusk
Department of Agricultural Economics Faculty Publications
The public is paying increased attention to the environmental impacts associated with cattle production systems in the US. Thus, cattle producers are increasingly exploring ways to communicate their efforts to reduce those environmental and climate impacts. This study uses online and social media data from 2018 to 2022 to examine public interest in and sentiment about beef and dairy cattle production when discussed within the context of greenhouse gas (GHG) emissions. Variation in mentions and net sentiment over the reporting period is quantified and analyzed. Over the period of data collection, which was interrupted by the COVID-19 pandemic, we find …
Needs Analysis Of Interactive Learning Media For Teachingheat Transfer In Physics: Students’ And Teachers’Perspectives, Rizki Eka Shintya, Ika Mustika Sari, Ida Kaniawati
Needs Analysis Of Interactive Learning Media For Teachingheat Transfer In Physics: Students’ And Teachers’Perspectives, Rizki Eka Shintya, Ika Mustika Sari, Ida Kaniawati
Jurnal Pendidikan Sains
Heat transfer material in physics is known to be abstract. This study specifically analyzes the conceptual difficulties, and visualization needs specific to this material, which is different from the analysis of physics needs in general. This analysis does not only look for the need for traditional media but explicitly looks for the need for interactive media (simulation, animation, virtual laboratory). Therefore, this study aims to identify the need for interactive learning media in physics education, specifically in the teaching of heat transfer, from the perspective of students and teachers in West Java, Indonesia. Using a quantitative descriptive survey, data were …
Understanding The Nutrition Ecology And Related Distal And Proximal Research Gaps Impacting School-Aged Children's And Adolescents' Functioning-A Report From The "Biomarkers Of Nutrition For Development: Knowledge Indicating Dietary Sufficiency (Bond-Kids)" Project Working Group 2., Maureen M Black, Meg M Bruening, Amy Carroll-Scott, Jayna M Dave, Kristie L Ebi, Lora L Iannotti, Susan L Johnson, Lorrene D Ritchie, Elizabeth Y Jimenez, Alison L Steiber, Daniel J Raiten
Understanding The Nutrition Ecology And Related Distal And Proximal Research Gaps Impacting School-Aged Children's And Adolescents' Functioning-A Report From The "Biomarkers Of Nutrition For Development: Knowledge Indicating Dietary Sufficiency (Bond-Kids)" Project Working Group 2., Maureen M Black, Meg M Bruening, Amy Carroll-Scott, Jayna M Dave, Kristie L Ebi, Lora L Iannotti, Susan L Johnson, Lorrene D Ritchie, Elizabeth Y Jimenez, Alison L Steiber, Daniel J Raiten
Children’s Nutrition Research Center Staff Publications
Nutrition is critical to the health, development, and well-being of children and adolescents, operating through nutrients and the social and physical influences of dietary behaviors. Child and adolescent growth and development depend on complex biological systems interacting with the nutrition ecology. In this review, we focus on bidirectional interactions with the multilevel nutrition ecology, including distal systems (climate, geopolitical, and food systems) and proximal systems (community food options; health, social, and food services; and school policies and programs), all mediated by the family. Thus, the impact of nutrition on children's and adolescents' functional outcomes is dependent on understanding the multilevel …
Climate Change Projections Through Optimized Machine Learning And Deep Learning Models: A Comprehensive Analysis, Hala H. Youssef, Salma S. Mohammed, Hanan M. Amer, Abeer T. Khalil
Climate Change Projections Through Optimized Machine Learning And Deep Learning Models: A Comprehensive Analysis, Hala H. Youssef, Salma S. Mohammed, Hanan M. Amer, Abeer T. Khalil
Mansoura Engineering Journal
One major worldwide issue that has far-reaching effects on environmental stability and the avoidance of natural disasters is climate change. Developing efficient mitigating strategies depends on precise climate change forecasts. To predict important climate change indicators, including temperature fluctuations, greenhouse gas (CO2, N2O, CH4, and SF6) emissions, population dynamics, sea level changes, Arctic Sea ice extent, and Antarctica mass, this study evaluated the predictive capabilities of several Machine Learning (ML) and Deep Learning (DL) techniques. The set of machine learning algorithms includes Multiple Linear Regression (MLR), K-Nearest Neighbors (KNN), Support Vector Machines (SVMs), Artificial Neural Networks (ANN), Random Forest (RF), …
Re-Survey Of Blastocystis Infection In Free-Living Birds From Urban Xinxiang City, Xuehan Liu, Yingying Cao, Di An, Chengshui Liao, Ruibiao Wang, Bo Wen, Chunling Zhu, Huarun Sun, Longfei Zhang, Baoliang Qin, Yanhui Wang, Jianhe Hu, Yueyu Bai, Ke Ding, Lei Wang
Re-Survey Of Blastocystis Infection In Free-Living Birds From Urban Xinxiang City, Xuehan Liu, Yingying Cao, Di An, Chengshui Liao, Ruibiao Wang, Bo Wen, Chunling Zhu, Huarun Sun, Longfei Zhang, Baoliang Qin, Yanhui Wang, Jianhe Hu, Yueyu Bai, Ke Ding, Lei Wang
The Thai Journal of Veterinary Medicine
Blastocystis is the most ubiquitous intestinal protozoan parasite found in humans and animals worldwide. Commonly, ST7 and ST6 are the major Blastocystis subtypes reported in birds, and their frequencies fluctuate greatly with various factors. However, little literature is available on the prevalence and subtype characteristics of this parasite in free-living wild birds in the same city. For this purpose, a total of 114 fresh fecal specimens were collected from wild free-living birds in urban districts of Xinxiang city and tested for Blastocystis using PCR of the barcoding region of the small subunit ribosomal RNA (SSU rRNA) gene. The positive isolates …
Development Of Students Worksheet Based On Project-Based Learning To Train Critical Thinking Skills At Vocational High School, Dia Ayu Permatasari, Harun Nasruddin
Development Of Students Worksheet Based On Project-Based Learning To Train Critical Thinking Skills At Vocational High School, Dia Ayu Permatasari, Harun Nasruddin
Jurnal Pendidikan Sains
Critical thinking is a cognitive skill that helps identify problems and generate solutions, leading to logical decisions or considerations for solving those problems. Students' critical thinking skills can be trained through learning activities to further improve students' critical thinking skills with learning tools. Therefore, this research intends to produce a student worksheet based on project-based learning to train students' critical thinking skills on the colligative properties of solutions. The development research uses the 4D development model from Thiagarajan, limited to the development stage. A limited trial was conducted with 30 students of industrial chemical engineering expertise at Vocational High School …
Development Of Digital Comic Learning Media Based On Mobile Learning On Media: Making Media Materials In Plant Tissue Culture, Sufina Intan Pertiwi, Fauziyah Harahap, Aline Gusti Yolanda Harahap, Marsya Amira Indrawati, Aline Jelita Christiani Simanullang, Yanda Febry Gracea Br Tarigan, Maureen Efriyanti Sitinjak
Development Of Digital Comic Learning Media Based On Mobile Learning On Media: Making Media Materials In Plant Tissue Culture, Sufina Intan Pertiwi, Fauziyah Harahap, Aline Gusti Yolanda Harahap, Marsya Amira Indrawati, Aline Jelita Christiani Simanullang, Yanda Febry Gracea Br Tarigan, Maureen Efriyanti Sitinjak
Jurnal Pendidikan Sains
his research was conducted based on student needs analysis, analysis of learner characteristics, and curriculum analysis, namely the lack of visualization and presentation of concepts and the lack of utilization of interactive technology in the learning process on media material and media making in tissue culture for college students. This study intends to develop digital comic media based on mobile learning and making media materials in tissue culture. This research method used research and development (R&D) with the ADDIE model: analyze, design, develop, implement, and evaluate. The subjects of this study were students of the Department of Biology, Universitas Negeri …
Dual Targeting Of Orphan Nuclear Receptors Nr4a1 And Nr4a2 For Nonhormonal Endometriosis Therapy, Wai Ning Tiffany Tsui, Yuri Park, Srijana Upadhyay, Da Mi Kim, Lei Zhang, Gus Wright, Amanuel Hailemariam, Arafat Rahman Oany, Sang Jun Han, Stephen Safe
Dual Targeting Of Orphan Nuclear Receptors Nr4a1 And Nr4a2 For Nonhormonal Endometriosis Therapy, Wai Ning Tiffany Tsui, Yuri Park, Srijana Upadhyay, Da Mi Kim, Lei Zhang, Gus Wright, Amanuel Hailemariam, Arafat Rahman Oany, Sang Jun Han, Stephen Safe
Faculty, Staff and Students Publications
Previous studies show that orphan nuclear receptor 4A1 (NR4A1) regulates endometriotic cell growth, survival, estrogen receptor β (ERβ), mechanistic target of rapamycin signaling and fibrosis. NR4A2 is also expressed in epithelial and stromal derived endometriotic cells, and in this study the effects of 1,1-bis(3'-indolyl)-(3,5-disubstitutedphenyl)methane (DIM-3,5) dual NR4A1/nuclear receptor 4A2 (NR4A2) ligands and knockdown of NR4A1 and NR4A2 were investigated. The dual NR4A1/2 DIM-3,5 analogs inhibited previously identified proendometriotic pathways and gene products, and they also inhibited TWIST1 and multiple markers associated with epithelial-to-mesenchymal transition (EMT). The results show that both NR4A1 and NR4A2 regulate the same pathways, including endometriotic cell …
Multimodal Reprogramming Of The Tumor Microenvironment By Mmr And Dual Checkpoint Blockade In Hepatocellular Carcinoma Models, Mulu Z. Tesfay, Aleksandra Cios, Khandoker Usran Ferdous, Randal S. Shelton, Bahaa Mustafa, Camila C. Simoes, Murat Gokden, Isabelle R. Miousse, Kimberly J. Krager, Marjan Boerma, Alicja Urbaniak, Anuradha Kunthur, Sri Obulareddy, Joshua M. Eichhorn, Steven R. Post, Jean Christopher Chamcheu, Omeed Moaven, Chiswili Y. Chabu, Dan G. Duda, Matteo Conti, Bruno Nardo, Rang Govindarajan, Martin E. Fernandez-Zapico, Lewis R. Roberts, Mitesh J. Borad, Martin J. Cannon, Alexei G. Basnakian, Bolni M. Nagalo
Multimodal Reprogramming Of The Tumor Microenvironment By Mmr And Dual Checkpoint Blockade In Hepatocellular Carcinoma Models, Mulu Z. Tesfay, Aleksandra Cios, Khandoker Usran Ferdous, Randal S. Shelton, Bahaa Mustafa, Camila C. Simoes, Murat Gokden, Isabelle R. Miousse, Kimberly J. Krager, Marjan Boerma, Alicja Urbaniak, Anuradha Kunthur, Sri Obulareddy, Joshua M. Eichhorn, Steven R. Post, Jean Christopher Chamcheu, Omeed Moaven, Chiswili Y. Chabu, Dan G. Duda, Matteo Conti, Bruno Nardo, Rang Govindarajan, Martin E. Fernandez-Zapico, Lewis R. Roberts, Mitesh J. Borad, Martin J. Cannon, Alexei G. Basnakian, Bolni M. Nagalo
School of Graduate Studies Faculty Publications
Hepatocellular carcinoma (HCC) is a leading cause of cancer-related death worldwide, thus, there is an urgent need to develop more effective therapeutic options for this dismal condition. Tumor-infiltrating lymphocytes (TILs) are associated with improved response to immune checkpoint blockade in HCC, but their low abundance in most cases limits their therapeutic efficacy. Here, we demonstrate, in mice, that low-dose intratumoral immunovirotherapy with the trivalent measles, mumps, and rubella vaccine (MMR) induces superior tumor-growth delay and extended host survival compared to individually administered vaccines for measles, mumps, or rubella viruses. Further, our results show that MMR therapy synergizes with PD-1 and …
Synaptic Transmission Promotes Brain Metastatic Outgrowth In Breast Cancer, Jayanta Mondal, Patrick Nylund, Prit Benny Malgulwar, William E Johnson, Jason T Huse
Synaptic Transmission Promotes Brain Metastatic Outgrowth In Breast Cancer, Jayanta Mondal, Patrick Nylund, Prit Benny Malgulwar, William E Johnson, Jason T Huse
Faculty, Staff and Student Publications
This work demonstrates that normal neuron-to-neuron signaling machinery is hijacked by metastasizing cancer cells during their outgrowth in the central nervous system.
Representation Is Power: Traditional, Hybrid, And Digital Recruitment Results From A Non-Randomized Clinical Trial Engaging Adolescents, Taylor B Harrison, Jessica A Sinclair, Lisa J Martin, Kristin Childers-Buschle, Holly Elder, Sunyang Fu, Hongfang Liu, William B Brinkman, Melanie F Myers, Michelle L Mcgowan
Representation Is Power: Traditional, Hybrid, And Digital Recruitment Results From A Non-Randomized Clinical Trial Engaging Adolescents, Taylor B Harrison, Jessica A Sinclair, Lisa J Martin, Kristin Childers-Buschle, Holly Elder, Sunyang Fu, Hongfang Liu, William B Brinkman, Melanie F Myers, Michelle L Mcgowan
Faculty, Staff and Student Publications
Clinical trials support the iterative advancement of modern medicine. However, challenges in achieving population-representativeness or participant sampling commensurate with the burden of disease can limit the generalizability and reproducibility of trial results. Here, we present the recruitment strategies and cohort profile of the Engaging Adolescents in Decisions about Return of Genomic Research Results non-randomized clinical trial (NCT0448106), where traditional, targeted hybrid, and digital recruitment methods were implemented with quota sampling to enroll diverse adolescents (ages 13-17) and young adults (ages 18-21). The largest proportion of participants enrolled through digital strategies (39.1%), followed by traditional (34.2%), and targeted hybrid strategies (23.2%). …
Design Principles For Deployable Fibers Inspired By Hagfish Defense, Mohammad Tanver Hossain, Wonsik Eom, Pallab Layak, Jeongmin Kim, Carolyn Darling, Andrew Lowe, Douglas S. Fudge, Sameh H. Tawfick, Randy Ewoldt
Design Principles For Deployable Fibers Inspired By Hagfish Defense, Mohammad Tanver Hossain, Wonsik Eom, Pallab Layak, Jeongmin Kim, Carolyn Darling, Andrew Lowe, Douglas S. Fudge, Sameh H. Tawfick, Randy Ewoldt
Biology, Chemistry, and Environmental Sciences Faculty Articles and Research
Hagfish produce extraordinary slime as a defense mechanism, releasing exudate from glands that rapidly form a fibrous, soft, ultra-dilute, water-capturing network upon contact with seawater (up to 10 000 times its original volume). The gland thread cell (GTC) produces high-strength protein threads (filament diameter df = 1–3 µm) meticulously coiled into skeins (coil diameter Do ∼ 150 µm) that rapidly unravel upon deployment to reveal their hidden length (Lf = 15 cm), forming a cohesive fibrous slime network through interaction with mucin vesicles and seawater. To date, no engineered material is able to replicate the fiber …
Advances In Fret Methodologies For Probing Molecular Interactions, Geetika Verma, Vasanthi Jayaraman
Advances In Fret Methodologies For Probing Molecular Interactions, Geetika Verma, Vasanthi Jayaraman
Faculty, Staff and Student Publications
Förster resonance energy transfer (FRET) has evolved into a powerful, quantitative approach for probing biomolecular structure, dynamics, and interactions. This research highlight brings together recent studies in Biophysical Journal that push the boundaries of traditional FRET. These innovations expand the spatial and temporal resolution of FRET, enabling its application to increasingly complex biological systems.
Consciousness Below Scuba Depths, Michael Vecchione
Consciousness Below Scuba Depths, Michael Vecchione
Animal Sentience
Abstract: Jennifer Mather has nicely summarized what is known about consciousness in shallow water octopods as well as what is known about shallow water squids and cuttlefish. However, once she gets below SCUBA depths, she misses out on most of cephalopod diversity. I have attempted to add this aspect and perhaps some evolutionary biology to this target article.
Inflammation And Mutational Burden Differentially Associated With Nivolumab Or Ipilimumab Combination Efficacy In Colorectal Cancer, Ming Lei, Michael J Overman, Jin Yao, Thierry André, Sara Lonardi, Heinz-Josef Lenz, Massimo Aglietta, Fabio Gelsomino, Ray Mcdermott, Ka Yeung Mark Wong, Michael A Morse, Eric Van Cutsem, Alain Hendlisz, Dana B Cardin, Bart Neyns, Andrew Hill, Anuradha Krishnamurthy, Franklin Chen, Samith Kochuparambil, Robert R Jenq, Sandzhar Abdullaev, Beilei He, Ruslan Novosiadly, Scott Kopetz
Inflammation And Mutational Burden Differentially Associated With Nivolumab Or Ipilimumab Combination Efficacy In Colorectal Cancer, Ming Lei, Michael J Overman, Jin Yao, Thierry André, Sara Lonardi, Heinz-Josef Lenz, Massimo Aglietta, Fabio Gelsomino, Ray Mcdermott, Ka Yeung Mark Wong, Michael A Morse, Eric Van Cutsem, Alain Hendlisz, Dana B Cardin, Bart Neyns, Andrew Hill, Anuradha Krishnamurthy, Franklin Chen, Samith Kochuparambil, Robert R Jenq, Sandzhar Abdullaev, Beilei He, Ruslan Novosiadly, Scott Kopetz
Faculty, Staff and Student Publications
Nivolumab alone and in combination with ipilimumab demonstrated durable clinical benefit in patients with previously treated microsatellite instability-high/mismatch repair-deficient metastatic colorectal cancer in the phase 2 CheckMate 142 study. Here, we report exploratory biomarker analyses from CheckMate 142 evaluating associations between various tissue biomarkers and the efficacy of nivolumab monotherapy and nivolumab plus ipilimumab combination in these patients. Higher expression of inflammation-related gene expression signatures is associated with improved response per investigator assessment and survival benefit with nivolumab monotherapy. In contrast, higher tumor mutational burden, tumor indel burden, and degrees of microsatellite instability are associated with improved response per investigator …
The Effects Of Plastic Mulch And Irrigation On Hemp Chemistry And Leaf Endophytes, Allison Rietman, Connor Morozumi, Robert C. Pearce, Natalie Christian
The Effects Of Plastic Mulch And Irrigation On Hemp Chemistry And Leaf Endophytes, Allison Rietman, Connor Morozumi, Robert C. Pearce, Natalie Christian
Journal of Agricultural Hemp Research
As an emerging crop, cultivation techniques for industrial hemp (Cannabis sativa L.) are still being developed and optimized. For example, irrigation and plastic mulching are some management practices that have been touted for their benefits in improving crop quality. Both techniques ensure ample water availability, which has often been attributed to improving hemp cannabinoid and terpene composition. In this study, we examined how supplemental irrigation implemented in a plastic mulch system influenced the cannabinoid and terpene profiles of one cultivar of CBD hemp, Lifter. We grew industrial hemp in field with plastic mulch and applied regular irrigation to one group …
Notes On Reproduction, Seasonality, And Roost Sites For Silver-Haired Bats (Lasionycteris Noctivagans) In Western Nebraska, Joseph W. Paysen, Dawson V. Kosmicki, Keith Geluso
Notes On Reproduction, Seasonality, And Roost Sites For Silver-Haired Bats (Lasionycteris Noctivagans) In Western Nebraska, Joseph W. Paysen, Dawson V. Kosmicki, Keith Geluso
Transactions of the Nebraska Academy of Sciences and Affiliated Societies
Silver-haired Bats (Lasionycteris noctivagans) are a migratory species found throughout the United States, southern Canada, and northern Mexico. Throughout their range, Silver-haired Bats roost in various tree species, generally within decaying features like cavities and exfoliated bark. Herein we report on additional reproductive and seasonal data as well as the first data on trees used as roost sites by Silver-haired Bats in Nebraska. We captured individuals along a small tributary of the North Platte River at Ash Hollow State Historical Park, Garden County, Nebraska, and tracked bats to their roosts. At this location, we documented lactation on 17 …