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Articles 6511 - 6540 of 113584
Full-Text Articles in Entire DC Network
The Garden Of Pdyn: The Impact Of Pdyn Gene Deletion On Ethanol Self-Administration And Reinforcement In Female Mice, Catherine Ruan
The Garden Of Pdyn: The Impact Of Pdyn Gene Deletion On Ethanol Self-Administration And Reinforcement In Female Mice, Catherine Ruan
CMC Senior Theses
Debilitating over-consumption of alcohol, often culminating into a prevalent psychiatric disorder known as alcohol use disorder (AUD), stands as one of the United States’ most expensive societal battles to face (Harwood et al., 1998). Consequently, the public’s desire and scientists’ motivation to develop novel pharmacological solutions to treat it is high. Recent and ongoing research presents new insights into the role of the dynorphin/kappa opioid receptor (DYN/KOR) system as an inhibitor of dopamine release and a regulator of the negative affective states that come with alcohol withdrawal (Karkhanis et al., 2017). However, this growing body of literature is predominantly conducted …
The Coral Porites Lutea As A Regional And Local Proxy For Sea Surface Temperature In Hong Kong, And The Effects Of Typhoons On Proxy Accuracy, Brenna E. Bell
The Coral Porites Lutea As A Regional And Local Proxy For Sea Surface Temperature In Hong Kong, And The Effects Of Typhoons On Proxy Accuracy, Brenna E. Bell
CMC Senior Theses
Proxies related to the climate have been used as a method to observe long-term changes occurring underwater that span long before we had the capability to measure environmental characteristics. Porites corals have been used as sea surface temperature (SST) proxies due to annual cyclicity in their growth process and mineral composition. As the climate differs globally, it is important to ensure that proxies are accurate regardless of location to measure changes in climate. This study examines Porites lutea corals as an SST proxy in the region of Hong Kong. Potential local differences in SST proxy calibrations within the surrounding waters …
Phytochemical Analysis, Antioxidant, And Antibacterial Properties Of Partition Fractions Of Adansonia Digitata And Annona Muricata Extracts Using Chloroform, Ethyl Acetate, Ethanol, And Aqueous Solvent Systems, Fagbohun Oyenike Bushirat, Hassan Abdusalam Adewuyi, Sakariyau Adio Waheed, Maryam Nana Musa, Timothy God-Giveth Olusegun, Ayomide Babatunde Ishola, Agumage Idoko, Adeola Victor Kolawole, Adesanmi Adefunmilayo Oluwatuyi, Sarah Ngozi Agwasim
Phytochemical Analysis, Antioxidant, And Antibacterial Properties Of Partition Fractions Of Adansonia Digitata And Annona Muricata Extracts Using Chloroform, Ethyl Acetate, Ethanol, And Aqueous Solvent Systems, Fagbohun Oyenike Bushirat, Hassan Abdusalam Adewuyi, Sakariyau Adio Waheed, Maryam Nana Musa, Timothy God-Giveth Olusegun, Ayomide Babatunde Ishola, Agumage Idoko, Adeola Victor Kolawole, Adesanmi Adefunmilayo Oluwatuyi, Sarah Ngozi Agwasim
Chemistry & Biochemistry Faculty Publications
Adansonia digitata and Annona muricata are traditionally used medicinal plants with reported pharmacological properties. In this study, we aimed to elucidate the phytochemical composition, antioxidant activity, and antibacterial properties of partition fractions of Adansonia digitata and Annona muricata extracts obtained using chloroform, ethyl acetate, ethanol, and aqueous solvent systems. The plant extracts were successively partitioned using chloroform, ethyl acetate, ethanol, and aqueous solvent systems. Phytochemical analysis was performed using standard methods. Antioxidant activity was evaluated using FRAP and DPPH assays. Antibacterial activity was assessed using agar well diffusion and MIC determination. Phytochemical analysis revealed the presence of alkaloids (10.2-15.6%), flavonoids …
The Nesting Ecology Of Southern Two-Lined Salamanders (Eurycea Cirrigera) In Urban Streams, Leah T. Rittenburg, Emma G. Downing, Todd Pierson
The Nesting Ecology Of Southern Two-Lined Salamanders (Eurycea Cirrigera) In Urban Streams, Leah T. Rittenburg, Emma G. Downing, Todd Pierson
Faculty Articles
Urbanization alters many aspects of stream ecosystems, and its effects upon wildlife will likely increase as more watersheds become developed. This may be particularly true for species with complex life histories, which could be vulnerable in different life stages. Eurycea cirrigera (Green) (Southern Two-lined Salamanders) are common members of many stream communities in the southeastern United States, and they prefer to nest in cobble with little sedimentation—a microhabitat that is threatened by stream degradation. We collected data on the nesting ecology of this amphibian species in urban streams in Atlanta, Georgia, to evaluate microhabitat availability, nest-site selection, and the influence …
Contents, Discovery Editors
Contents, Discovery Editors
Discovery, The Student Journal of Dale Bumpers College of Agricultural, Food and Life Sciences
No abstract provided.
Discovery: The Student Journal Of Dale Bumpers College Of Agricultural, Food And Life Sciences - Volume 26 2025, Several Authors
Discovery: The Student Journal Of Dale Bumpers College Of Agricultural, Food And Life Sciences - Volume 26 2025, Several Authors
Discovery, The Student Journal of Dale Bumpers College of Agricultural, Food and Life Sciences
No abstract provided.
Featured Faculty Mentor/Student Team, Kelly Loftin, Eva Berryhill
Featured Faculty Mentor/Student Team, Kelly Loftin, Eva Berryhill
Discovery, The Student Journal of Dale Bumpers College of Agricultural, Food and Life Sciences
No abstract provided.
Effectiveness Of Maternal Bovine Appeasing Substance Administered To Newly Received, High-Risk Stocker Calves, Elle Johnston, Rosie Whittle, Robin Cheek, Beth Kegley, Jeremy Powell, Shawna Weimer
Effectiveness Of Maternal Bovine Appeasing Substance Administered To Newly Received, High-Risk Stocker Calves, Elle Johnston, Rosie Whittle, Robin Cheek, Beth Kegley, Jeremy Powell, Shawna Weimer
Discovery, The Student Journal of Dale Bumpers College of Agricultural, Food and Life Sciences
Stocker cattle purchased at auction can be susceptible to disease due to the stressors associated with the auction process and are referred to as “high-risk.” The objective of this study was to determine the efficacy of a maternal bovine appeasing substance, FerAppease®, on the growth performance, health, and behavior of stocker cattle. Male beef calves (n = 80) were purchased at auction and transported to the University of Arkansas System Division of Agriculture Savoy Research Complex Beef Stocker Unit. On day 0, bulls were castrated, and steers and bulls were assigned to 8 pens (n = 10 calves/pen; …
Effect Of Traditional Versus Fenceline Weaning On Lamb Stress, Emma N. Sutton, Kenneth P. Coffey, Eva Wray, Derico Setyabrata, Bryan Kutz, Shawna Weimer
Effect Of Traditional Versus Fenceline Weaning On Lamb Stress, Emma N. Sutton, Kenneth P. Coffey, Eva Wray, Derico Setyabrata, Bryan Kutz, Shawna Weimer
Discovery, The Student Journal of Dale Bumpers College of Agricultural, Food and Life Sciences
Stress in sheep can negatively affect productivity and increase their susceptibility to illness and parasites. The traditional method of weaning lambs is the abrupt separation of lambs from their dams. An alternative method of weaning, fenceline weaning, where offspring are separated from their dams by a single fence but retain visual and auditory contact, has been found to reduce stress in cattle and may also reduce stress in sheep. The objectives of this study were to evaluate body weights, fecal egg counts, and behavior to determine if traditional or fenceline weaning has lower stress associated with weaning in lambs. The …
Effects Of Fiber Concentrations And Fermentation Rates On Reproductive Performance, Nutrient Digestibility, Immune Response, And Microbiota Of Lactating Sows, Tao Wang, Pieter Langendijk, Paula Azevedo, Lluis Faba, Bin Zuo, Jiangchao Zhao, Chengbo Yang
Effects Of Fiber Concentrations And Fermentation Rates On Reproductive Performance, Nutrient Digestibility, Immune Response, And Microbiota Of Lactating Sows, Tao Wang, Pieter Langendijk, Paula Azevedo, Lluis Faba, Bin Zuo, Jiangchao Zhao, Chengbo Yang
Animal Science Faculty Publications and Presentations
Certain types of fiber inclusion in sow diets can offer benefits such as promoting a healthy microbiome, improving intestinal health, and enhancing welfare through satiety mechanisms. While most research has focused on gestating sows, studies on lactating sows, especially regarding fiber types, levels, and fermentation rates, are limited. This study explored how fiber inclusion and fermentation rate affect lactation performance, nutrient digestibility, immune response, and microbiota. The study involved 136 lactating sows (Landrace x Large White) assigned to four dietary treatments with varying total dietary fiber (TDF) levels and proportions of fast-fermentable fiber. Diets 1 and 2 had low TDF …
Generative Ai (Gan & Vae) In Motion Sickness Research, Harigovind Harikumar, Tomojit Ghosh
Generative Ai (Gan & Vae) In Motion Sickness Research, Harigovind Harikumar, Tomojit Ghosh
Celebration of Undergraduate & Graduate Research, Scholarship, and Creative Activities Materials
No abstract provided.
A Systematic Study Of Freezing Behavior In Earthworms In Response To Auditory And Vibratory Stimuli, Navjot Singh, A. Burton, Dragana Ivkovich Claflin
A Systematic Study Of Freezing Behavior In Earthworms In Response To Auditory And Vibratory Stimuli, Navjot Singh, A. Burton, Dragana Ivkovich Claflin
Celebration of Undergraduate & Graduate Research, Scholarship, and Creative Activities Materials
While earthworms have largely been studied for their role in eliminating toxic metals from soil, less is known about their behavior overall. Previous work from our lab found that a predator-like auditory stimulus (grunting) reliably induced fear-related freezing behavior (Worthen et al., 2024). The present studies further explore earthworm behaviors in response to audio-vibratory stimuli. In Experiment 1, we manipulated amplitude levels and speaker location to examine the parameters needed to reliably induce a freezing fear response to the grunting sound. It was hypothesized that when the speaker was touching the apparatus and producing an added mechanical vibration, there would …
Epilepsy: Etiology And Treatment Methods, Avital Nightingale
Epilepsy: Etiology And Treatment Methods, Avital Nightingale
The Science Journal of the Lander College of Arts and Sciences
Epilepsy is a common neurological disorder that is caused by abnormal electrical activity in the brain. Due to the evolution of our understanding of epilepsy and its causes, a variety of therapeutic options have been developed to modulate seizures and limit their occurrence rate. Medication, diet and surgery have been the traditional treatments offered to individuals suffering from epilepsy but the latest advancements in neurotechnology have given patients with drug resistant epilepsy hope by providing options other than surgery. While the disorder is a complex one and its pathogenesis not yet fully understood, recent research has provided insight into the …
Strategies To Address The Growing Impact Of The Antibiotic Resistance Crisis, Rina Balter
Strategies To Address The Growing Impact Of The Antibiotic Resistance Crisis, Rina Balter
The Science Journal of the Lander College of Arts and Sciences
As time progresses, more bacterial strains are becoming resistant to the antibiotics developed to treat them. Impeding such intractable infections should be a major clinical priority, as previously treatable diseases have begun to incur a fatality rate that will escalate catastrophically unless it is halted. This research paper explores relevant information regarding the advances in developing alternative strategies to antibiotics to combat antimicrobial resistant (AMR) bacteria, within the context of clinical application. Recognizing the profound impact antimicrobial resistance (AMR) will have on patient health enables the implementation of proactive measures to curb the expanding prevalence of multidrug-resistant (MDR) pathogens. This …
Full Issue: Volume 18, Number 2, Spring 2025
Full Issue: Volume 18, Number 2, Spring 2025
The Science Journal of the Lander College of Arts and Sciences
Complete .pdf file of Volume 18, Number 2 of The Science Journal of the Lander College of Arts and Sciences. Published Spring 2025.
Full Issue: Volume 19, Number 1, Fall 2025
Full Issue: Volume 19, Number 1, Fall 2025
The Science Journal of the Lander College of Arts and Sciences
Complete .pdf file of Volume 19, Number 1 of The Science Journal of the Lander College of Arts and Sciences. Published Fall 2025.
Does Chronic Stress Play A Role In The Genesis Of Neurodegenerative Diseases?, Rachelle Halpert
Does Chronic Stress Play A Role In The Genesis Of Neurodegenerative Diseases?, Rachelle Halpert
The Science Journal of the Lander College of Arts and Sciences
Chronic stress has been increasingly recognized as a major contributor to the onset and progression of neurodegenerative diseases such as Alzheimer’s and Parkinson’s disease. This paper explores the correlation between chronic stress and neurodegeneration by reviewing population, clinical, and animal studies. Studies show that long-term stress disrupts the hypothalamic-pituitary-adrenal (HPA) axis, impairs hippocampal function, increases oxidative stress, and promotes neuroinflammation. These processes are all implicated in cognitive decline. The mechanisms through which these processes occur are discussed including elevated glucocorticoid levels, shortened telomeres, mitochondrial dysfunction, and the activity of pro-inflammatory microglia. Lastly, potential interventions are reviewed, including lifestyle modifications such …
Can Deadly Toxins Become Tools For Medicine?, Esther Gross
Can Deadly Toxins Become Tools For Medicine?, Esther Gross
The Science Journal of the Lander College of Arts and Sciences
Natural toxins, long feared as deadly poison, are increasingly being harnessed as powerful medicine. This paper explores the growing role of animal and plant toxins in modern medicine, tracing their use from ancient remedies to cutting-edge biomedical science. Through a study of their biochemical mechanisms, therapeutic applications, and clinical case histories, this paper draws attention to the remarkable specificity and potency of toxin-derived compounds for disease treatment in diabetes, chronic pain, cancer, cardiovascular disease, etc. This paper also investigates the scientific and practical barriers to the universal clinical application of toxins, such as issues of toxicity, cost, stability, and ethical …
Should Crispr Be Available As A Widespread Gene Therapy For Humans?, Mirel Leifer
Should Crispr Be Available As A Widespread Gene Therapy For Humans?, Mirel Leifer
The Science Journal of the Lander College of Arts and Sciences
The CRISPR/Cas gene editing tool was discovered in 2012 and since then has been researched extensively. It has many applications in the research and medical world and has been the topic of many discussions since its discovery. This paper describes several of the advantages of CRISPR; what it has been used for and the potential that it contains. Among those advantages are sickle cell treatment, Alzheimer’s treatment, coupling CRISPR with induced pluripotent stem cells(iPSCs), and the cancer battle. Also discussed in this paper are number of concerns that surround this new gene therapy. Among those are medical concerns and ethical …
Does Prenatal Stress Have Prenatal And Life-Long Effects?, Miriam Lavizadeh
Does Prenatal Stress Have Prenatal And Life-Long Effects?, Miriam Lavizadeh
The Science Journal of the Lander College of Arts and Sciences
Maternal prenatal stress (MPS) has a unique impact on the developing fetus and the child’s life post birth. Pregnancy is a highly anxious time for a lot of women. Many have pregnancy related concerns as well as overall stress from environmental and societal factors. However, this takes a toll on the fetus’s development which can later cause different cognitive and health outcomes in the child. During a time of stress, one’s HPA axis gets activated causing the release of various hormones, particularly cortisol and catecholamines. These hormones can cross the placental barrier called HSD11B2-11β-hydroxysteroid dehydrogenase 2, exposing the sensitive and …
The Role Of The Gut–Brain Axis In Irritable Bowel Syndrome, Malky Weiss
The Role Of The Gut–Brain Axis In Irritable Bowel Syndrome, Malky Weiss
The Science Journal of the Lander College of Arts and Sciences
The gastrointestinal (GI) system and the brain share a highly integrated relationship mediated by the gut–brain axis, with implications across a range of medical disciplines. Irritable bowel syndrome (IBS) is the most prevalent disorder of gut brain interaction (DGBI) which affects a significant portion of the global population, yet its pathophysiology has historically been poorly understood. This review examines the development and maintenance of IBS, drawing on literary sources to explore the gut–brain axis and disease expression which occurs as a result of its dysfunction. Common pathological features of IBS include visceral hypersensitivity, altered serotonin signaling, inappropriate immune activation, and …
Implant Alternatives: The Advancements Of Stem Cells In Regenerative Dentistry, Akiva Goldschmidt
Implant Alternatives: The Advancements Of Stem Cells In Regenerative Dentistry, Akiva Goldschmidt
The Science Journal of the Lander College of Arts and Sciences
This research paper explores the potential of mesenchymal stem cells (MSCs) within the realm of dentistry, focusing particularly on their ability to repair tissues and regenerate entire teeth. MSCs are significant as they can send differentiation signals to nearby cells and release growth factors such as TGF-β and VEGF, which promote cellular activities necessary for dental repair and regeneration. The paper discusses the traditional methods of dental restoration, such as fillings and implants, and their inherent limitations. It then transitions to exploring innovative strategies that utilize MSCs to overcome these challenges and regenerate tooth structures including enamel, dentin, and periodontal …
Novel Pharmacotherapies For Treatment-Resistant Depression: Lysergic Acid Diethylamide (Lsd), Eliana Cohen
Novel Pharmacotherapies For Treatment-Resistant Depression: Lysergic Acid Diethylamide (Lsd), Eliana Cohen
The Science Journal of the Lander College of Arts and Sciences
Treatment Resistant Depression has become extremely prevalent with 30% of depression cases being unresolvable. Psychedelics specifically Lysergic Acid Diethylamide has been a newfound unconventional approach that has demonstrated significant benefits for depression. LSD is a hallucinogenic drug mainly acting on the serotonin receptors that leads to altered sensory and perception affecting mood. This research paper comprehensively examines animal and human studies on LSD’s healing properties and enduring effects. The studies find that LSD induces neuroplasticity, and alters gene expressions associated with synaptogenesis and neurogenesis. Additionally LSD affects the activity of different neurotransmitters in the central nervous system enhancing mood. Lastly …
Color Development Of Direct Acidified Pork Sausage Containing Alternative Curing And Reducing Agents, Jacob R. Tuell, Harley Francis, Sydney Bentz, Ashley R. Pitti, Morgan L. Denzer, Derico Setyabrata
Color Development Of Direct Acidified Pork Sausage Containing Alternative Curing And Reducing Agents, Jacob R. Tuell, Harley Francis, Sydney Bentz, Ashley R. Pitti, Morgan L. Denzer, Derico Setyabrata
Animal Science Faculty Publications and Presentations
This study evaluated the inclusion of preconverted alternative cures (celery powder [CELERY], beet powder [BEET]) compared to conventional sodium nitrite (NaNO2 [NITRITE]) formulated to 125 ppm of ingoing nitrite (NO2) in pork sausage acidified with encapsulated citric acid. Formulations included cherry powder (CHERRY) at 1000 ppm as an alternative cure accelerator, conventional sodium erythorbate (ERYTH) at 547 ppm, or no cure accelerator (NONE). The application of a holding period (OVERNIGHT) or not (IMMEDIATE) prior to thermal processing was evaluated. Batches (n = 3) were prepared in a 3 x 3 x 2 factorial arrangement of cures, accelerators, and holding periods. …
Erk1/2 Inhibition Alleviates Diabetic Cardiomyopathy By Suppressing Fatty Acid Metabolism, Erin Mclean, Caroline De Roo, Annabel Maag, Megan Coble, Jefferson Cano, Ruijie Liu
Erk1/2 Inhibition Alleviates Diabetic Cardiomyopathy By Suppressing Fatty Acid Metabolism, Erin Mclean, Caroline De Roo, Annabel Maag, Megan Coble, Jefferson Cano, Ruijie Liu
Open Access Publishing Support Funded Articles
Background: Diabetes mellitus is associated with morphological and functional impairment of the heart primarily due to lipid toxicity caused by increased fatty acid metabolism. Extracellular signal-regulated protein kinases 1 and 2 (ERK1/2) have been implicated in the metabolism of fatty acids in the liver and skeletal muscles. However, their role in the heart in diabetes remains unclear. In this study, we tested our hypothesis that pharmacological inhibition of ERK1/2 alleviates cardiac remodeling in diabetic mice through a reduction in fatty acid metabolism. Methods: ERK1/2 phosphorylation in diabetes was determined both in vitro and in vivo. H9C2 cells were subjected …
The Effects Of Salinity On The Cutaneous Microbiome And Pathogen Infection On The Pacific Tree Frog (Pseudacris Regilla) In Monterey Bay, California, Usa, Hannah Eunhae Kim
The Effects Of Salinity On The Cutaneous Microbiome And Pathogen Infection On The Pacific Tree Frog (Pseudacris Regilla) In Monterey Bay, California, Usa, Hannah Eunhae Kim
EWU Masters Thesis Collection
Global climate change and infectious diseases are considered a leading cause of amphibian population declines worldwide. Changes in precipitation and salinity have altered watershed systems and microbial communities, reducing habitat availability and physiological performances for amphibian survival. The salt refuge hypothesis, however, is a proposed explanation that higher saline environments may reduce susceptibility to pathogens such as Batrachochytrium dendrobatidis (Bd). The Moro Cojo Slough State Marine Reserve (MCSSMR) (California, USA) is known as an abundant breeding ground for endangered/threatened amphibian species. To test and expand the salt refuge hypothesis, I evaluated Bd prevalence and intensity and the cutaneous microbiome of …
Investigating The Relationships Between Biotic And Abiotic Factors Affecting Migratory Behavior In Westslope Cutthroat Trout Within The Pend Oreille System, Garrett M. Duncan
Investigating The Relationships Between Biotic And Abiotic Factors Affecting Migratory Behavior In Westslope Cutthroat Trout Within The Pend Oreille System, Garrett M. Duncan
EWU Masters Thesis Collection
Salmonids express several different life histories from migrating to oceans and back or staying in their natal streams as a resident. Migratory individuals are a vital part of the overall success of populations due to the potential for increased genetic diversity and increased fecundity they offer over resident individuals. This research was completed in three basins including Priest River, Pack River, and Lightning Creek which are all connected to the Pend Oreille Basin and are important producers of Westslope Cutthroat Trout (Oncorhynchus clarkii lewisi). Thirty-nine sites were sampled between the three basins. Results were compared between these tributaries that have …
The Seasonality And Community Composition Of Mosquitoes At Turnbull National Wildlife Refuge, Jonathan Becerra
The Seasonality And Community Composition Of Mosquitoes At Turnbull National Wildlife Refuge, Jonathan Becerra
EWU Masters Thesis Collection
Characterizing mosquito species composition and seasonal dynamics is fundamental to understanding how mosquito communities change across time and space. This study examined the structure, temporal patterns, and spatial variation of the mosquito community at Turnbull National Wildlife Refuge (TNWR) using three years of CDC light-trap data (2017–2019). We applied multiple complementary analytical approaches—including presence/absence and CPUE models, annual and species-specific generalized additive models (GAMs), peak-timing ANOVA, and multivariate analyses (NMDS, PERMANOVA, and indicator species analysis)—to quantify species-level seasonality, phenological staggering, and community-level patterns across years and between two sampling locations (Gate and Headquarters). Across all model families, species identity and …
Assessing Relatedness Of Copperbelly Water Snakes In A Captive Breeding Program, Dehlia Deriemaker
Assessing Relatedness Of Copperbelly Water Snakes In A Captive Breeding Program, Dehlia Deriemaker
Senior Honors Theses and Projects
Breeding threatened and endangered animals in captivity and their subsequent release can help supplement wild populations. Within captive breeding programs, maintaining genetic diversity is an important consideration for ensuring the survival of a species as a whole. Preserving genetic diversity increases population persistence, as it may offer a better chance for a species to adapt to a changing environment. The Copperbelly Water Snake (Nerodia erythrogaster neglecta, CWS) is listed as threatened by the U.S. Fish and Wildlife Service. In an effort to aid CWS recovery efforts, the Toledo Zoo manages a captive breeding program initially consisting of nine adult and …
Use Of Coculture And Carbon Source Manipulation To Stimulate Antibiotic Production In Soil-Dwelling Microbes, April R. Dembinski
Use Of Coculture And Carbon Source Manipulation To Stimulate Antibiotic Production In Soil-Dwelling Microbes, April R. Dembinski
Senior Honors Theses and Projects
This study aimed to discover new antibiotics produced by soil microbes. Previous studies have shown that manipulation of microbial growth conditions through variable carbon sources and growth in coculture could induce the production of novel antibiotics by soil microbes. This study expanded on these observations by testing the levels of antibiotic production when a producing strain was grown in twenty different carbon sources and cocultured with more than one hundred different coculture partners. Organic extracts from liquid cultures were tested against a panel of four safe relatives to ESKAPE pathogens and one yeast to detect antimicrobial activity. Certain combinations of …