Digital Commons Network^™

Halogeton And Greasewood Poisoning In Cattle And Sheep In Utah, E. Jane Kelly, Stephen T. Lee, Ammon Brown, Daniel Cook

Poisonous Plant Research (PPR)

Halogeton (Halogeton glomeratus) is a fast-growing annual plant while greasewood (Sarcobatus vermiculatus) is a perennial shrub of the Western States. Oxalates are the toxic principle in halogeton and greasewood. Most losses occur when hungry animals are allowed to graze in heavy stands of halogeton and greasewood. Halogeton and greasewood are always dangerous and become more toxic as the growing season progresses. Here we report on two clinical cases of halogeton and greasewood poisoning in cattle and sheep. Histologically, oxalate crystals were observed in the kidneys of the cow and sheep consistent with oxalate poisoning. Oxalate was …

Refurbishing Used Gps Transmitters Improves Performance For Subsequent Deployments On Greater Sage-Grouse, Melissa S. Chelak, Michel T. Kohl, Justin R. Small, Kurt T. Smith, Aaron C. Pratt, Jeffrey L. Beck, Codi R. Backen, M. Brandon Flack, Hailey P. Wayment, Jason A. Wood, Ryan Howell, Trevon D. Strange, Lucian R. Mcdonald, Kezia R. Manlove, Shandra N. Frey, Randy T. Larsen, Brian A. Maxfield, David K. Dahlgren, Terry A. Messmer, David C. Stoner

Wildland Resources Student Research

Global Positioning Systems (GPS) radio transmitters are increasingly used across taxa to monitor animal populations. However, GPS transmitters can be susceptible to malfunctions that may result in location errors or data loss causing potential inferential bias that can have important implications for monitored species. Research using GPS transmitters on greater sage-grouse (Centrocercus urophasianus; sage-grouse) has increased, but few sage-grouse studies have evaluated GPS performance. Because sage-grouse management has been subject to intense legal and political scrutiny with consequential economic implications, reliable data acquisition is central to informed decision-making for the species. We evaluated differences in the performance of …

Exploring The Pathogen Profiles Of Ancient Feces, Drew Capone, David Holcomb, Amanda Lai, Karl Reinhard, Joe Brown

Karl Reinhard Publications

Analysis of ancient desiccated feces – termed paleofeces or coprolites – can unlock insights into the lives of ancient people. We collected desiccated feces from caves in the Rio Zape Valley in Mexico (725-920 CE). First, we extracted DNA with methods previously optimized for paleofeces. Then, we applied highly sensitive modern molecular tools (i.e., PCR pre-amplification followed by multi-parallel qPCR) to assess the presence of 30 enteric pathogens. We detected ≥1 pathogen associated gene in each of the ten samples and a mean of 3.9 pathogens per sample. The targets detected included Blastocystis spp. (n=7), atypical enteropathogenic E. coli (n=7), …

Protein Translation Rates Are Negatively Correlated With Lifespan In Inbred Drosophila Strains, Harper S Kim, Madison M Hardiman, Andrew M Pickering

Faculty, Staff and Student Publications

No abstract provided.

Phase I Study Of Bms-986299, An Nlrp3 Agonist, As Monotherapy And In Combination With Nivolumab And Ipilimumab In Patients With Advanced Solid Tumors, Blessie E Nelson, Shaun O'Brien, Rahul A Sheth, David S Hong, Aung Naing, Xiaoping Zhang, Amy Xu, Lora Hamuro, Rasika Suryawanshi, Derrick Mckinley, Ruslan D Novosiadly, Sarina A Piha-Paul

Faculty, Staff and Student Publications

Purpose: BMS-986299 is a first-in-class, NOD-, LRR-, and pyrin-domain containing-3 (NLRP3) inflammasome agonist enhancing adaptive immune and T-cell memory responses.

Materials and methods: This was a phase-I (NCT03444753) study that assessed the safety and tolerability of intra-tumoral BMS-986299 monotherapy (part 1A) and in combination (part 1B) with nivolumab, and ipilimumab in advanced solid tumors. Reported here are single-center results.

Results: 36 patients were enrolled, with breast (31%), colorectal (17%), and head and neck (14%) being the more commonly enrolled cancers. Most patients (58%) had received prior immunotherapy. Therapy was well-tolerated, with G1-G2 fever (70%), neutrophilia (36%), and leukocytosis …

Mitochondrial A3 Adenosine Receptor As A Mechanism For The Protective Effects Of A3ar Agonists On Chemotherapy-Induced Neuropathic Pain, Timothy M. Doyle, Kali Janes, Wen Hua Xiao, Grant R. Kolar, Hans F. Luecke, Michael Anne Gratton, Dilip K. Tosh, Kenneth A. Jacobson, Gary J. Bennett, Daniela Salvemini

Biological Sciences Faculty Research & Creative Works

Alterations in mitochondrial function are the linchpin in numerous disease states including in the development of chemotherapy-induced neuropathic pain (CIPN), a major dose-limiting toxicity of widely used chemotherapeutic cytotoxins. In CIPN, mitochondrial dysfunction is characterized by deficits in mitochondrial bioenergetics (e.g., decreased ATP production) that are thought to drive the degeneration of the peripheral nerve sensory axon terminal sensory arbors in the skin (the intraepidermal nerve fibers; IENFs) and induce abnormal spontaneous discharge in peripheral nerve sensory axons. Preserving mitochondrial function is anticipated to prevent CIPN. We have now discovered that the G-protein-coupled receptor, A3 adenosine receptor subtype (A3AR), is …

Career: The Behavioral, Hormonal, And Neural Basis Of Coyote Monogamy, Sara M. Freeman

Funded Research Records

No abstract provided.

Electrostatic Force-Enabled Microneedle Patches That Exploit Photoredox Catalysis For Transdermal Phototherapy, Hang Zhang, Wen-Chuan Xie, Yuhang Yao, Zi-Yi Tang, Wen-Xiu Ni, Bingwu Wang, Song Gao, Jonathan L Sessler, Jun-Long Zhang

Faculty, Staff and Student Publications

Microneedle patches for topical administration of photodynamic therapy (PDT) sensitizers are attractive owing to their safety, selectivity, and noninvasiveness. However, low-efficiency photosensitizer delivery coupled with the limitations of the hypoxic tumor microenvironment remains challenging. To overcome these issues, we developed an effective microneedle patch based on intermolecular electrostatic interactions within a photosensitizer matrix containing a zinc-containing porphyrin analogue, ZnBP (w). This design improved the mechanical strength of the microneedle patch and enhanced the photosensitizer loading efficiency in aqueous environments. A key feature of the system is efficient electron transfer between ZnBP (w) and NADH upon photoirradiation. Electrostatic interactions between ZnBP …

A Case For Broadening Our View Of Mechanism In Developmental Biology, B Duygu Özpolat, Swathi Arur, Mansi Srivastava

Faculty, Staff and Student Publications

Developmental biologists can perform studies that describe a phenomenon (descriptive work) and/or explain how the phenomenon works (mechanistic work). There is a prevalent perception that molecular/genetic explanations achieved via perturbations of gene function are the primary means of advancing mechanistic knowledge. We believe this to be a limited perspective, one that does not effectively represent the breadth of work in our field. We surveyed a representative and diverse group of colleagues to share their views on what it takes to infer mechanism. Here, we briefly examine the factors that have shaped the dominant view of mechanism, summarize responses to the …

Anti-Ctla-4 Generates Greater Memory Response Than Anti-Pd-1 Via Tcf-1, Stephen Mok, Huey Liu, Didem Ağaç Çobanoğlu, Nana-Ama A S Anang, James J Mancuso, E John Wherry, James P Allison

Faculty, Staff and Student Publications

The effects of T cell differentiation arising from immune checkpoint inhibition targeting cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) and programmed cell death protein 1 (PD-1) on the immunological memory response remain unclear. Our investigation into the effects of anti-CTLA-4 and anti-PD-1 on memory T cell formation in mice reveals that memory T cells generated by anti-CTLA-4 exhibit greater expansion, cytokine production, and antitumor activity than those from anti-PD-1. Notably, anti-CTLA-4 preserves more T cell factor-1 (TCF-1)+ T cells during priming, while anti-PD-1 leads to more thymocyte selection-associated high mobility group box (TOX)+ T cells. Experiments using conditional

ʽAmqa: Faunal Remains From The Late Fatimid–Early Crusader Periods, Nimrod Marom

Qadum: Journal of Excavation Reports from Israel

This report analyzes faunal remains found in a building complex at ‘Amqa, primarily from the late Fatimid–early Crusader periods (eleventh–twelfth centuries CE). The assemblage consists mainly of cattle, sheep and goats, with a smaller number of camel, wild boar, equid, chicken and tortoise remains. Cattle bones, particularly from young individuals, are most prevalent, suggesting a focus on cattle rearing. Butchery marks indicate the use of tools for carcass processing, and bone fragmentation patterns suggest both intentional breakage and natural weathering. Comparisons with other sites from the same period highlight the unique predominance of cattle in ‘Amqa, possibly due to the …

Studying The Impact Of Weather Changes On Bird Breeding., Perle Suana, Yangyang Tao

Posters-at-the-Capitol

Climate change start to impact our daily life recently. The shifting climate introduces frequent and unpredictable temperature fluctuations. For species like birds, particularly those that reproduce through eggs, maintaining stable temperatures during incubation is crucial for reproductive success. Despite the significance of temperature stability, limited research has delved into understanding the thresholds of temperature tolerance during incubation. In this investigation, we will apply the data science tools to analyze the local temperature dataset over the past decade and the birds incubation dataset. Our aim was to explore potential correlations between extreme temperature swings coinciding with the breeding season and instances …

Grass Weed Control And Rice Response With Tetflupyrolimet-Containing Programs, Mason C. Castner, Jason K. Norsworthy, Thomas R. Butts, Trenton L. Roberts, Nick R. Bateman, Travis R. Faske

Crop, Soil and Environmental Sciences Faculty Publications and Presentations

Tetflupyrolimet is the first herbicide with a novel site of action (SOA) labeled PRE and early POST for use in agronomic crops to be labeled in the last three decades. Direct-seeded paddy rice field experiments were conducted near Stuttgart, AR, on a silt loam soil and near Keiser, AR, on a clay soil to evaluate tetflupyrolimet-containing herbicide programs in comparison to commercial standards in conventional, imidazolinone-resistant, and quizalofop-resistant rice systems. Additionally, a furrow-irrigated rice experiment was conducted near Colt, AR, and Keiser to ensure weed control with clomazone and tetflupyrolimet mixtures compared to commercial standards. Twelve commonly planted rice cultivars …

Agricultural Producers' Motivations And Challenges With Improving Soil Health In Utah, Peggy Petrzelka, Jessica Ulrich-Schad, Matt Yost, Jenae Dean, Tony Richards, Kristy Davis

All Current Publications

The Utah Soil Health Program (USHP) developed a five-year project to increase understanding of how best to implement soil health practices into Utah’s diverse farming systems. Fifteen producers were selected to participate in the USHP On-Farm Soil Health Demonstration Project. During 2022, the trial’s first year, the participating farmers and ranchers were interviewed. We begin by discussing participant demographics and operation characteristics. Next, we turn to challenges the producers faced in implementing soil health practices in the IMW and then turn to motivations for the producers to enroll in the USHP trial. This will help (1) document what is currently …

Root Decomposition And Nutrient Dynamics In Multifunctional Forage-Biomass Buffer-Strip Systems, Helen C.S. Amorium, Amanda J. Ashworth, Taylor C. Adams, Mary C. Savin, Philip A. Moore Jr

Crop, Soil and Environmental Sciences Faculty Publications and Presentations

Perennial crops are thought as a solution for enhancing food security and providing ecosystem services under a changing climate, including forage-biomass production, reduced erosion and nutrient leaching, and soil C accumulation. However, the drivers of root decomposition and C allocation in perennial multifunctional forage-biomass buffer-strips as affected by fertility management are poorly elucidated. Thus, study objectives were to assess root decomposition and soil CO2 efflux on switchgrass (Panicum virgatum L.), eastern gamagrass (Tripsacum dactyloides L.), silphium (Silphium integrifolium Michx.), and intermediate wheatgrass Kernza (Thinopyrum intermedium [Host] Barkworth & D.R. Dewey) treated with poultry litter (PL) relative to the unfertilized control. …

Supporting Wildlife Restoration In Eastern States Via State Wildlife Action Plans, L. Mark Elbroch, John Vucetich, Christa Rose, Jeremy T. Bruskotter

Michigan Tech Publications

The biodiversity crisis is driven by extinction at two scales: the global extinction of species and the local extirpation of populations (i.e., range contraction). Local extirpations are especially acute in the eastern United States, which has lost a substantial portion of its native mammalian fauna. Species restoration in the U.S., therefore, should be utilised more to revitalise and restore degraded systems. State wildlife agencies can elevate discussions about species restoration and facilitate internal capacity to conduct restoration projects by including locally extirpated species in State Wildlife Action Plans, which are currently under revision, and will guide state conservation programs for …

Combined Kras Inhibition And Immune Therapy Generates Durable Complete Responses In An Autochthonous Pdac Model, Yonghong Liu, Jincheng Han, Wen-Hao Hsu, Kyle A Labella, Pingna Deng, Xiaoying Shang, Paulino Tallón De Lara, Li Cai, Shan Jiang, Ronald A Depinho

Faculty, Staff and Student Publications

Pancreatic ductal adenocarcinoma (PDAC) resists conventional chemo/radiation and immunotherapy. In PDAC, oncogenic KRAS (KRAS*) drives glycolysis in cancer cells to consume available glucose and produce abundant lactate, creating profound immune suppression in the tumor microenvironment. Here, we combined KRAS* inhibition with agents targeting the major arms of the immunity cycle: CXCR1/2 inhibitor for myeloid cells, antagonistic anti-LAG3 antibody for T cells, and agonistic anti-41BB antibody for dendritic cells. This combination elicited robust anti-tumor regression in iKPC mice bearing large autochthonous tumors. While untreated mice succumbed within 3 weeks, sustained treatment led to durable complete tumor regression and prolonged survival in …

Neutrophil Extracellular Traps Promote Pre-Metastatic Niche Formation In The Omentum By Expanding Innate-Like B Cells That Express Il-10, Wonjae Lee, Song Yi Ko, Hironari Akasaka, Melanie Weigert, Ernst Lengyel, Honami Naora

Faculty, Staff and Student Publications

Disseminated cancer cells in the peritoneal fluid often colonize omental fat-associated lymphoid clusters but the mechanisms are unclear. Here, we identify that innate-like B cells accumulate in the omentum of mice and women with early-stage ovarian cancer concomitantly with the extrusion of chromatin fibers by neutrophils called neutrophil extracellular traps (NETs). Studies using genetically modified NET-deficient mice, pharmacologic inhibition of NETs, and adoptive B cell transfer show that NETs induce expression of the chemoattractant CXCL13 in the pre-metastatic omentum, stimulating recruitment of peritoneal innate-like B cells that in turn promote expansion of regulatory T cells and omental metastasis through producing …

Nerves At Play: The Peripheral Nervous System In Extracranial Malignancies, Paola D Vermeer, Anthony C Restaino, Jeffrey L Barr, Dan Yaniv, Moran Amit

Faculty, Staff and Student Publications

The exponential growth of the cancer neuroscience field has shown that the host's immune, vascular, and nervous systems communicate with and influence each other in the tumor microenvironment, dictating the cancer malignant phenotype. Unraveling the nervous system's contributions toward this phenotype brings us closer to cancer cures. In this review, we summarize the peripheral nervous system's contributions to cancer. We highlight the effects of nerve recruitment and tumor innervation, the neuro-immune axis, glial cell activity, and neural regulation on cancer development and progression. We also discuss harnessing the neural control of peripheral cancers as a potential therapeutic approach in oncology. …

Zongertinib (Bi 1810631), An Irreversible Her2 Tki, Spares Egfr Signaling And Improves Therapeutic Response In Preclinical Models And Patients With Her2-Driven Cancers, Birgit Wilding, Lydia Woelflingseder, Anke Baum, Krzysztof Chylinski, Gintautas Vainorius, Neil Gibson, Irene C Waizenegger, Daniel Gerlach, Martin Augsten, Fiona Spreitzer, Yukina Shirai, Masachika Ikegami, Sylvia Tilandyová, Dirk Scharn, Mark A Pearson, Johannes Popow, Anna C Obenauf, Noboru Yamamoto, Shunsuke Kondo, Frans L Opdam, Annemarie Bruining, Shinji Kohsaka, Norbert Kraut, John V Heymach, Flavio Solca, Ralph A Neumüller

Faculty, Staff and Student Publications

Mutations in ERBB2 (encoding HER2) occur in 2% to 4% of non-small cell lung cancer (NSCLC) and confer poor prognosis. ERBB-targeting tyrosine kinase inhibitors, approved for treating other HER2-dependent cancers, are ineffective in HER2-mutant NSCLC due to dose-limiting toxicities or suboptimal potency. We report the discovery of zongertinib (BI 1810631), a covalent HER2 inhibitor. Zongertinib potently and selectively blocks HER2, while sparing EGFR, and inhibits the growth of cells dependent on HER2 oncogenic driver events, including HER2-dependent human cancer cells resistant to trastuzumab deruxtecan. Zongertinib displays potent antitumor activity in HER2-dependent human NSCLC xenograft models and enhances the activities of …

A Byzantine-Period Monastery And Farmhouse In Nahal Pehar (Giv‘Ot Bar), In The Northern Negev, Nir-Shimshon Paran

'Atiqot

A Byzantine-period monastery and farmhouse were uncovered on the southwestern bank of Naḥal Peḥar, within the modern settlement of Giv‘ot Bar, in the northern Negev. The monastery was well-preserved, attesting to the daily life of the monks in the Negev in the Byzantine period. It was paved with poorly executed mosaic floors, probably laid by the monks themselves. Most of the finds in the monastery were uncovered on the floors, attesting to its orderly abandonment in the late Byzantine or beginning of the Umayyad period (sixth–seventh centuries CE). The monastery seems to have belonged to the widespread ecclesiastical system documented …

Intermediate Bronze Age Fauna From A Suspected Cultic Area At Nahal RefaʼIm, Liora Kolska Horwitz

'Atiqot

A small assemblage of faunal remains was recovered from four archaeological contexts excavated on the northern bank of Naḥal Refaʼim. These include Bronze Age rock-cut pits (Area 100), a structure (Area 300), a burial cave (Area 500) and an Ottoman-period shomera (Area 400). The remains represent almost exclusively domestic taxa—sheep, goat, cattle and donkey—some of which exhibit butchery marks, other modifications or burning. The faunal assemblage from the pits, together with other complementary data, may attest that the pits were used as favissae (cultic storage pits) associated with ritual activities at the site.

Intermediate Bronze Age, Middle Bronze Age Ii And Iron Age Ii Pottery From Nahal Refa’Im, Lilly Gershuny

'Atiqot

The pottery assemblage from the Naḥal Refa’im site originated in three different archaeological contexts: pits, structure(s) and a burial cave. These findings attest that the main period of occupation was during the Intermediate Bronze Age. One pit may have been reused for burial in Middle Bronze Age II, and the burial cave was visited in Iron Age II, possibly by the inhabitants of nearby Khirbat er-Ras.

Intermediate And Middle Bronze Age Settlement Remains, Domestic Worship, Pits And Burial Practices In Nahal RefaʼIm, Jerusalem, Shlomit Weksler-Bdolah, Alexander Onn

'Atiqot

Excavations on the northern bank of the Refa’im Valley uncovered four sites: a shaft tomb and building remains with a standing stone dating to the Intermediate Bronze Age; a concentration of eight pits dating to the Intermediate Bronze Age and the Middle Bronze Age II; and an Ottoman-period agricultural watchtower. The building remains and installations were probably part of the Intermediate Bronze Age settlement along Naḥal Refa’im. The standing stone’s prominent location, and the large concentration of pits and installations near it, may support its identification with domestic worship. The thin fill at the bottom of some of the pits …

Light-Microscopic And Spectroscopic Analyses Of The Skin Materials Used In The Tefillin And Mezuzah Slips From The Judean Desert, Yonatan Adler, Theresa Emmerich Kamper

'Atiqot

Among the Dead Sea Scrolls is an assemblage of ancient tefillin and mezuzah slips—ritual artifacts composed of thin animal skins inscribed with passages from the Pentateuch. This paper presents the results of light-microscopic and spectroscopic analyses conducted on 26 tefillin and 8 mezuzot from the Judean Desert caves. These analyses provide the first opportunity to identify the following characteristics on these artifacts: animal species; skin thickness; skin layers present; tannage; side/s of skin with writing. In time, these characteristics took on ritual significance, especially in later rabbinic halakhah. A significant finding is that the ancient tefillin analyzed here were all …

An Iron Age Iib–C Hebrew Stamp Seal With Apotropaic And Prophylactic Properties From The Southwestern Corner Of The Temple Mount, Jerusalem, Filip Vukosavović, Ronny Reich, Navot Rom, Yuval Baruch

'Atiqot

An Iron Age Hebrew iconic stamp seal was uncovered near the southwestern corner of the Temple Mount in Jerusalem. The seal, made of black stone, depicts a winged genie and a personal name, Yehoʽezer son of Hoshaʽyahu. This is the first depiction of the winged genie iconography in the region found in an archaeological excavation. Influenced by Neo-Assyrian art, the seal was created in Jerusalem by a local artist for Hoshaʽyahu, a member of the Judean elite, during the Assyrian Century. Later on, the seal was inherited by his son, Yehoʽezer. In addition to being used as a stamp, the …

Evidence Of Worship In The Rock-Cut Rooms On The Eastern Slope Of The City Of David, Jerusalem, Eli Shukron, Liora Freud, Helena Roth, Reli Avisar, Efrat Bocher

'Atiqot

This paper presents the finds retrieved from a unique series of rock-cut rooms found on the eastern slope of the City of David. These rock-cut rooms stand out in terms of their architectural features, as well as the artifacts discovered within them, all of which reflect on their function as a cultic complex, likely constructed in the Middle Bronze Age, with its final stage in Iron Age IIB. This complex offers profound evidence for the diversity of cultic practices in the capital of the Kingdom of Judah.

The Emergence Of Worship And Religion In The Neolithic Period: Direct And Indirect Evidence From Moẓa (Motza), Hamoudi Khalaily, Anna Eirikh-Rose, Ianir Milevski

'Atiqot

Evidence of worship and religion in the form of architectural remains is rather scanty before the shift in human behavior, from hunter-gatherers to sedentary communities, and the emergence of permanent settlements. Communal and ritual structures first appeared in the Natufian culture (12,500–9400 BCE) and expanded during the Neolithic period (9400–5300 BCE), alongside the treatment of burials linked to ritual related to ancestor worship. The excavations at Motza’s Final PPNB (7100–6700 BCE) layer exposed many non-residential structures, some presumably used for worship and ritual. Some burials, including the one interpreted here as a shaman burial, included objects of symbolic importance. Cultic …

А Review Of Scorpiofauna Of China: Nomenclatural Notes And Updated Faunistic Catalogue (Arachnida: Scorpiones), Victoria Tang

Euscorpius

Two genera associated with the Chinese scorpiofauna are reviewed, Razianus Farzanpay, 1987 and Reddyanus Vachon, 1972. Holotype female of Razianus xinjianganus Lourenço et al., 2010 is presumed to be lost, as well as all type material of other Chinese scorpions described before 2020. Comments are given on the species composition of genus Reddyanus with a new synonym: Isometrus (Reddyanus) tibetanus Lourenço & Zhu, 2008 = Reddyanus assamensis (Oates, 1888) syn. n. Reddyanus kanak Lourenço, 2023 is tentatively considered as a nomen dubium. An updated catalogue of Chinese scorpiofauna is provided, including their type locality and type depository, protonym, synonym(s), …

Changes In Vertical Stratification Of Neotropical Nymphalid Butterflies At Forest Edges Are Not Directly Caused By Light And Temperature Conditions, Brian K. Oye, Ryan I. Hill

Pacific Faculty Work

Habitat fragmentation and land use changes threaten neotropical habitats and alter patterns of diversity at forest edges. Like other arthropod assemblages, neotropical fruit-feeding butterfly communities show strong vertical stratification within forests, with some recent work showing its potential role in speciation. At forest edges, species considered to be forest canopy specialists have been observed descending to the forest understory, with the similarity in light conditions between the canopy and understory strata at edges hypothesized to be responsible for this phenomenon. We conducted a study using standardized sampling to document and quantify this edge effect, characterize edge and forest strata, and …